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Wechsler Intelligence Scale

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1601. The effect of magnetic resonance imaging on human cognition. (Abstract)

periods: the Wechsler Adult Intelligence Scale-Revised (Digit Span, Block Design and Digit Symbol), the Wechsler Memory Scale Paired Associate Learning test, the Benton Revised Visual Retention test, the Vandenberg Mental Rotation test, the Sternberg memory scanning paradigm and the State Anxiety Inventory. The overall analysis of results indicated that MRI at 0.15 T has no significant effect upon the cognitive functions assessed.

1987 Magnetic resonance imaging Controlled trial quality: uncertain

1602. A crossover trial of bromocriptine in the treatment of vascular dementia. (Abstract)

A crossover trial of bromocriptine in the treatment of vascular dementia. Seven patients with vascular dementia completed an 8-month randomized double-blind crossover trial of bromocriptine in a dosage of up to 30 mg per day. Patients were assessed using a modified UCLA Parkinson Rating Scale of symptoms and signs, and neuropsychological testing including the Wechsler Adult Intelligence Scale-Revised, Wechsler Memory Scale, modified Thurstone Word Fluency Test, Wisconsin Card Sort, a test

1988 Annals of neurology Controlled trial quality: uncertain

1603. Effects of antihypertensive therapy on blood pressure control, cognition, and reactivity. A placebo-controlled comparison of prazosin, propranolol, and hydrochlorothiazide. (Abstract)

improvement from baseline than the other treatment groups on the block design subscale of the Wechsler Adult Intelligence Scale-Revised, and there was a trend for the propranolol group to have less improvement from baseline than the other groups on the digit span subscale. There were no other significant pretreatment to post-treatment changes in the other cognitive or psychomotor tests, the Russell Revision of the Wechsler Memory Scale, or a number of computerized reaction-time and signal-detection tasks

1989 The American journal of medicine Controlled trial quality: uncertain

1604. Cognitive and behavioral findings in children taking theophylline. (Abstract)

was actually switched from theophylline to cromolyn sodium therapy. Assessment again consisted of the revised Wechsler Intelligence Scale for Children, the Selective Reminding test, the Benton Visual Retention test, Stroop tests I and II, and the Child Behavior Checklist. The group receiving placebo theophylline/active cromolyn sodium therapy demonstrated greater improvement on all tests of memory and concentration, with greatest significance for the Stroop test (p less than 0.03 by analysis of covariance

1988 The Journal of allergy and clinical immunology Controlled trial quality: uncertain

1605. Efficacy of almitrine-raubasine in cognitive disorders of aging: a double-blind, placebo-controlled, clinical and psychometric study. (Abstract)

, the other placebo, two tablets daily for 90 days. They were assessed at T0, T45 and T90 days, using the Toulouse-Pieron test, 8 subtests from the Wechsler Adult Intelligence Scale (WAIS) and the Sandoz Clinical Assessment for Geriatrics (SCAG). End-of-study results were significantly better in the almitrine-raubasine group in all tests: Toulouse-Pieron test (p less than 0.001), WAIS (p less than 0.001), and SCAG (p less than 0.001).

1990 Clinical neuropharmacology Controlled trial quality: uncertain

1606. Phototherapy for neonatal hyperbilirubinemia: six-year follow-up of the National Institute of Child Health and Human Development clinical trial. (Abstract)

and developmental examinations were conducted at 1 and 6 years of age, with follow-up rates of 83% and 62%, respectively. The two groups did not differ in mortality or diagnosed medical conditions. The phototherapy and control groups had similar rates of cerebral palsy (5.8% vs 5.9%), other motor abnormalities including clumsiness and hypotonia (11.1% vs 11.4%), and sensorineural hearing loss (1.8% vs 1.9%). The Wechsler Intelligence Scale for Children-Revised scores overall were not significantly different

1990 Pediatrics Controlled trial quality: uncertain

1607. [Preliminary study of traditional Chinese medicine treatment of minimal brain dysfunction: analysis of 100 cases]. (Abstract)

group, and the TCM group had more beneficial effects to improve intelligence, enuresis and the black of orbits. The study showed that the Verbal Scale in Wechsler Intelligence Scale for children is one of the indications of diagnosis and evaluating of the curative effect of MBD. (...) , Scutellaria baicalensis, Astragalus membranaceus, Codonopsis pilosula, Ligustrum lucidum, Lophatherum gracile and thread of ivory. The WM group (20 cases) were treated with retalin 5-15 mg twice daily. One course of treatment lasted one month, and effects were evaluated after 1-3 courses of treatment. The results were as follows: In the TCM group, 23 cases were cured (clinical symptom and sign disappeared, 10 IQ units were raised in their intelligence, abnormal electroencephalogram was recovered

1990 Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine / Zhongguo Zhong xi yi jie he yan jiu hui (chou), Zhong yi yan jiu yuan, zhu ban Controlled trial quality: uncertain

1608. The effects of haloperidol on thought disorder and IQ in schizophrenia. (Abstract)

The effects of haloperidol on thought disorder and IQ in schizophrenia. The impact of haloperidol treatment on the Wechsler Adult Intelligence Scale (WAIS) and the Thought Disorder Index was investigated in a group of 19 patients with schizophrenia tested both before and after 26 days of treatment with haloperidol. Thought disorder scores declined significantly over the course of treatment and fewer patients demonstrated severe forms of thought disorder at the end of the trial. WAIS performance

1990 Journal of personality assessment Controlled trial quality: uncertain

1609. Estrogen improves psychological function in asymptomatic postmenopausal women. (Abstract)

estrogens (0.625 and 1.25 mg) on psychological function over 3 months in 36 asymptomatic women, aged 45-60. The tests included the Minnesota Multiphasic Personality Inventory-168, the Profile of Adaptation to Life, and the Beck Depression Inventory. Memory was assessed directly by the Wechsler Adult Intelligence Scales, measuring both digit span and digit symbol. All women were well-adjusted psychologically. The income management scale of the Profile of Adaptation to Life improved (P less than .05 (...) ) with estrogen, as did the Beck Depression Inventory (P less than .05), but these results were not dose-related. Memory assessed prospectively by the Wechsler Adult Intelligence Scales was not affected significantly. These results suggest that estrogen use may improve the overall quality of life in postmenopausal women.

1991 Obstetrics and Gynecology Controlled trial quality: uncertain

1610. Long-term cognitive and social sequelae of general versus regional anesthesia during arthroplasty in the elderly. (Abstract)

Long-term cognitive and social sequelae of general versus regional anesthesia during arthroplasty in the elderly. This study compared the effects of general and regional anesthesia on cognitive and psychosocial functioning in elderly persons. Sixty-four patients between 60 and 86 yr of age undergoing knee arthroplasty were randomly assigned to receive either general or regional anesthesia. A battery of psychometric tests, including the Satz-Mogel form of the Wechsler Adult Intelligence Scale (...) -Revised, the Wechsler Memory Scale-Revised and the Sickness Impact Profile, and various neuropsychological measures were administered by a blinded observer just before surgery and again 3 months later. Analyses of covariance revealed improvements in most measures that were equivalent between groups. The results indicated that there were no cognitive or psychosocial effects of general or regional anesthesia after 3 months in elderly persons undergoing knee arthroplasty. In this patient population

1990 Anesthesiology Controlled trial quality: uncertain

1611. Developmental Phenomenology of Obsessive Compulsive Disorder and Tourette Syndrome in Children and Adolescents

-II), Yale Best Estimate of Diagnoses Schedule (Y-BEDS), Natural History Evaluation, Yale Natural History Questionnaire (YHNQ), Social Readjustment Scale for Children, Neuropsychologic Assessment, Delayed Response Tasks, Continuous Performance Task, Continuous Recognition Memory, Selective Reminding Procedures, Card Sorting Tasks, Wechsler Intelligence Scale for Children-Revised, Digit Span, Digit Symbol and Mazes Paced Auditory, Serial Addition Task, Purdue Pegboard Trail Making Tasks, Fluency (...) Tasks, Rey-Osterreith Complex Figure Stanford-Binet Intelligence Scale-Fourth Edition, Physical, Neurologic, and Neurochemical Assessment Physical exam (abbreviated), Physical and Neurological Examination for Soft Signs (PANESS), 24-hour urinary cortisol and catecholamines, Family History and Family Function Assessment of family history, Assessment of Family Functioning. The estimated duration of study is 10 years. Study Design Go to Layout table for study information Study Type : Observational

1999 Clinical Trials

1612. Effect of Estrogen on Mental and Social Functioning in Girls With Turner's Syndrome

by girls with Turner's syndrome. PURPOSE: Clinical trial to study the effectiveness of long term estrogen therapy on mental and social functioning in girls who have Turner's syndrome. Condition or disease Intervention/treatment Phase Turner's Syndrome Drug: Estrogen Not Applicable Detailed Description: PROTOCOL OUTLINE: Participants are evaluated for cognitive and social function at entry and 4 years following entry. Assessments include the Wechsler Intelligence Scale for Children-Revised, a child (...) behavior checklist, the Children's Self-Concept Scale, and visual-spatial, visual-motor, attention, memory, language, and facial recognition tasks. Patients (and parents) undergo X-chromosome analysis; brain magnetic imaging is optional. Controls are matched using school selection and telephone interviews. A study duration of 12 years is estimated. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Enrollment : 260 participants Primary Purpose: Treatment

1999 Clinical Trials

1613. Randomized Study of Intensive One-on-one Behavioral Treatment for Preschool Aged Children With Autism

, involved 3+ months of individualized training for parents on applied behavior analysis intervention Outcome Measures Go to Primary Outcome Measures : Wechsler Preschool and Primary Scales of Intelligence, 3rd ed. [ Time Frame: yearly for up to 4 years ] IQ Bayley Scales of Infant Development [ Time Frame: yearly for up to 4 years ] Alternate cognitive test administered to participants who did not achieve basal on WPPSI-III Secondary Outcome Measures : Merrill-Palmer Scale of Mental Tests [ Time Frame (...) : yearly for up to 4 years ] Nonverbal cognitive skills Reynell Developmental Language Scales [ Time Frame: yearly for up to 4 years ] Language comprehension and expressive language Vineland Adaptive Behavior Scales - Survey Edition [ Time Frame: yearly for up to 4 years ] Parent interview on child's adaptive functioning Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family

1999 Clinical Trials

1614. Infant Heart Surgery: Central Nervous System Sequelae of Circulatory Arrest

using standardized measures of cognition, behavior, language, attention, and motor skills. The primary outome variable for the developmental evaluation was the intelligence quotient on the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-R). Secondary outcome variables included measurements of behavior and performance in specific domains of speech and language, visual motor integration, attention, motor function, and temperament. Beginning in January 1998, the study was extended (...) period. The outcomes of primary interest (magnetic resonance imaging, neurologic examination, and psychometric testing) were reviewed at the one-year evaluation, to maximize relevance to the long-term prognosis. Pre-operative and seven-to-ten day post-operative neurologic examination was also carried out. Developmental status at one year was measured by the Bayley developmental scales and the Fagan test of infant intelligence. Brain function was assessed by neurologic examination at one year

1999 Clinical Trials

1615. Cardiopulmonary bypass, temperature, and central nervous system dysfunction. (Abstract)

cold heart surgery. The examinations took place preoperatively, 5 days after operation, and a 3-month follow-up. The examination consisted of a clinical neurological examination and a brief neuropsychological test battery. The neuropsychological tests included the Buschke selective reminding procedure, the Wechsler memory scale-revised visual reproduction subtest, the trial making test (parts A and B), the Wechsler adult intelligence scale-revised digit symbol subtest, and the grooved pegboard test (...) of memory (Buschke, Wechsler memory scale) showed no evidence of patient deterioration in the postoperative period. No difference was seen between the warm and cold groups.In this randomized trial of normothermic versus hypothermic CPB, we found deterioration in scores of tests of psychomotor speed but not of memory in the early postoperative period. We were unable to demonstrate any neuroprotective effect from moderate hypothermia in this patient population.

1994 Circulation Controlled trial quality: uncertain

1616. [Comparative study of nicardipine versus placebo in the prevention of cognitive deterioration in patients with transient ischemic attack]. (Abstract)

to a Wechsler's intelligence scale, and their memory was also tested before and after this period. Although no alterations were registered on either scale, some differences did appear in certain sub-tests, especially as regards the verbal coefficient. This pilot study has provided information concerning the possible beneficial effect of the drug, which should be proven by means of a larger-scale study.

1996 Revista de neurologia

1617. Neuropsychological performance on tests of frontal-lobe functioning and aggressive behavior in men. (Abstract)

Neuropsychological performance on tests of frontal-lobe functioning and aggressive behavior in men. The authors tested the relationship between frontal-lobe functioning and physical aggression in young men in a laboratory setting. Seventy-two men completed two putative neuropsychological measures of frontal-lobe functioning--the Self-Ordered Pointing (SOP) Task and the Conditional Association Task (CAT)--and an abbreviated version of the Wechsler Adult Intelligence Scale--Revised. Aggression

1994 Journal of abnormal psychology Controlled trial quality: uncertain

1618. Effects of moclobemide on depressive symptoms and cognitive performance in a geriatric population: a controlled comparative study versus imipramine. (Abstract)

imipramine. Psychiatric conditions and symptoms were rated at 0, 7, 14, 30, 45, and 60 days after the beginning of the trial by means of the Scale for the Assessment of Psychoorganic Syndromes, Hamilton Rating Scale for Depression, Rome. Depression Inventory, Hamilton Anxiety Rating Scale, State-Trait Anxiety Inventory-X form, and the Clinical Global Impression Scale. Cognition was tested through the Benton visual retention test at days 0, 30, and 60 and the Digit Substitution Test of the Wechsler Adult (...) Intelligence Scale at days 0 and 60. Side effects were assessed through the Dosage Record Emergent Symptoms at days 0, 7, 14, 30, 45, and 60. The dropout rate was significantly greater in the moclobemide group. Both drugs induced an improvement in depressive and anxious symptomatology, with moclobemide showing a faster onset. Furthermore, moclobemide showed an enhancing effect on cognition, which was not shown by imipramine. Such results indicate that moclobemide could prove to be the drug of choice

1994 Clinical neuropharmacology Controlled trial quality: uncertain

1619. Antagonic-stress. A new treatment in gerontopsychiatry and for a healthy productive life. (Abstract)

Depression and Anxiety Scales; as well as psychometric testing by digit symbol of WAIS, Wechsler Memory Scale and Wechsler Adult Intelligence Scale (WAIS). Except PL, prolonged and large dose treatments with these cerebral activators (MF, NE and especially AS) reduced the psychogeriatric-psychopathological scores and the deterioration index, and improved cognitive performance. The therapeutical effectiveness of AS multiple formula in gerontopsychiatry and its superiority vs. monotherapy (MF or NE (...) with axis III physical disorders or conditions, and in multiinfarct dementia were followed by AS vs. MF or NE investigations in senile dementia of Alzheimer's type. A total of 343 old people, distributed in 4 PL groups, 1 MF group, 1 NE group, and 5 AS groups were studied. Multiple investigations, before and after three-month treatments were made: psychometric evaluation by Sandoz Clinical Assessment-Geriatric, Self-Assessment Scale-Geriatric and their 5 subscales; psychopathological rating by Hamilton

1994 Annals of the New York Academy of Sciences Controlled trial quality: uncertain

1620. Superiority of antagonic-stress composition versus nicergoline in gerontopsychiatry. (Abstract)

, and parallel clinical trial was performed on 62 old people divided into 2 groups and exclusively treated with NE or AS. Psychogeriatric evaluations (Sandoz Clinical Assessment-Geriatric scale, Self-Assessment Scale-Geriatric and their subscales) and psychometric tests (digit symbol of WAIS, Wechsler Memory Scale, and Wechsler Adult Intelligence Scale-WAIS) were made before and after 3 months of treatment. Prolonged and large dose treatments with NE and AS significantly decreased the psychogeriatric scores

1994 Annals of the New York Academy of Sciences Controlled trial quality: uncertain

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