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Wechsler Intelligence Scale

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141. Predicting developmental outcomes in preterm infants: A simple white matter injury imaging rule. (PubMed)

of 60 neonates with 4.5-year outcomes were reformatted and aligned to the posterior commissure-eye plane and WMI was classified by location: anterior or posterior-only to the midventricle line on the reformatted axial plane. Adverse outcomes at 4.5 years were defined as Wechsler Preschool and Primary Scale of Intelligence full-scale IQ <85, cerebral palsy, or Movement Assessment Battery for Children, second edition percentile <5. The prediction of adverse outcome by WMI location, intraventricular

2019 Neurology

143. Tasimelteon (Hetlioz)

) Tasimelteon capsules 4 Table of Tables Table 1: Brief description of individual clinical studies in the development program 19 Table 2: Sleep complaint questionnaire 23 Table 3: Schedule of evaluations during randomization phase (Study 3201) 25 Table 4: Schedule of evaluations during randomization phase (Study 3203) 26 Table 5: Non-24 Clinical Response Scale Components and Criteria for Response 39 Table 6: Results of primary and step down primary endpoints – Study 3201 40 Table 7: Results of primary (...) and decreases daytime nap duration. Tasimelteon significantly improves the timing of sleep relative to the desired bedtime. Tasimelteon is significantly efficacious in treating Non-24 Hour Disorder as measured by clinically meaningful improvement in the Non-24 Clinical Response Scale. Treatment with 20 mg of tasimelteon for 26 weeks significantly improves global functioning as measured by the Clinical Global Impression-Change (CGI-C). Tasimelteon treatment is necessary for entrainment, maintenance

2013 FDA - Drug Approval Package

144. Composite Resin and Amalgam Dental Filling Materials: A Review of Safety, Clinical Effectiveness and Cost-effectiveness

was to evaluate the long-term harms of amalgam; the primary outcome in the NECAT was the difference in change of the intelligence quotient (IQ) index between children in the amalgam and composite groups. The primary outcome in the CPCAT was the difference between groups in the change of neurological responses as measured by a composite of memory, attention/concentration, motor/visuo-motor, and nerve conduction velocity tests. Secondary safety outcomes in both trials included renal responses, immunological

2012 Canadian Agency for Drugs and Technologies in Health - Rapid Review

145. Characteristics of sleep in socially vulnerable adolescents. (PubMed)

. Cognitive assessment was based on the Wechsler Abbreviated Scale of Intelligence and ADHD by a clinical interview the Multimodal Treatment Study for ADHD (MTA-SNAP-IV).The average duration of sleep per night were 6 h 30 m. 80% of the sample presented sleep complains. Of these, 44% had excessive daytime sleepiness and 69.6% had poor sleep quality related to use of electronic media, environmental violence, and emotional issues. There were no significant associations between sleep problems and cognitive (...) by a Catholic institution, in Porto Alegre, southern Brazil.125 male and female high school students.As first step the subjects were administered specific questionnaires, the Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS), followed by an educational activity that was combined with an unblinded, randomized interventional study. Next, a cross-sectional study was conducted to determine the influence of cognition and ADHD on the sleep.Sleep was evaluated using PSQI and ESS

2018 European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society Controlled trial quality: uncertain

146. A Natural History Study In Chinese Male Patients With Duchenne Muscular Dystrophy

) [ Time Frame: Change from baseline, 12, 24, 30 Months ] Change from Baseline in Wechsler Intelligence Scale for Children (WISC) score in ambulatory subjects aged >=6 years to <=16 years [ Time Frame: Chang from baseline, 24 Months ] The WISC is individually administered intelligence test for children between ages of 6 and 16. It generates a Full Scale Intelligence Quotient. Secondary Outcome Measures : Proportion of subjects with mutation of large deletion [ Time Frame: Baseline ] Proportion (...) evaluator determined scales - Expanded Hammersmith Functional Motor Scale [ Time Frame: Change from baseline, 6, 12, 18, 24, 30 Months ] Change from Baseline in clinical evaluator determined scales - Northstar Ambulatory Assessment [ Time Frame: Change from baseline, 6, 12, 18, 24, 30 Months ] The Northstar Ambulatory Assessment will be performed in ambulatory children >=3 years old Change from Baseline in clinical evaluator determined scales - Performance of Upper Limb [ Time Frame: Change from

2018 Clinical Trials

147. Prevalence, clinical correlates and IQ of suicidal ideation in drug naïve Chinese Han patients with major depressive disorder. (PubMed)

(PIQ) and full-scale IQ (FIQ) scores were measured using the Chinese version of the Wechsler Adult Intelligence Scale-Ⅲ (WAIS-Ⅲ). We categorized patients with SI based on a cut-off score of ≥3 on HAMD item 3.An estimated prevalence 32.8% (160/488) of drug-naïve MDD patients experienced SI during the current episode of illness. Patients with SI were more likely to be divorced (x2 = 6.93, p = 0.031), male (x2 = 6.04, p = 0.014), had higher severity of depression and anxiety symptoms (t = -8.14, p  (...) Prevalence, clinical correlates and IQ of suicidal ideation in drug naïve Chinese Han patients with major depressive disorder. Suicidal ideation (SI) is a common and serious clinical concern in people with major depressive disorder (MDD). Inconsistent evidence suggests that individuals with SI may have a lower measured intelligence quotient (IQ) than those without SI. The aims of this study were to examine SI prevalence and its associations with demographic, clinical variables and IQ in Chinese

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2018 Journal of Affective Disorders

148. Clinical effects of repetitive transcranial magnetic stimulation combined with atomoxetine in the treatment of attention-deficit hyperactivity disorder. (PubMed)

of People's Liberation Army of China. These patients were randomly assigned to three groups according to treatment method: the rTMS group, the ATX group, and the rTMS+ ATX group. Before treatment and 6 weeks after treatment, clinical symptoms and executive functions of ADHD patients were evaluated with the Swanson, Nolan, and Pelham, Version IV (SNAP-IV) Questionnaire, continuous performance test, three subtests (arithmetic, digit span, and coding) of Wechsler Intelligence Scale for Children, as well (...) as Iowa Gambling Tasks (IGT). The effects of treatment were compared among three groups.After 6 weeks of treatment, the scores of all factors in the SNAP-IV questionnaire were lower than those before treatment in the three groups; the scores of three subtests of Wechsler Intelligence Scale for Children, continuous performance test, and IGT were also significantly higher than those before treatment. The rTMS+ ATX group had a better improvement in attention deficits and hyperactivity impulse on the SNAP

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2018 Neuropsychiatric disease and treatment Controlled trial quality: uncertain

149. Fatty fish, hair mercury and cognitive function in Norwegian preschool children: Results from the randomized controlled trial FINS-KIDS. (PubMed)

Intelligence Scale-III (WPPSI-III) pre- and post-intervention. Linear mixed effect models were used to analyze changes in THHg and WPPSI-III scores.The mean (SD) THHg pre-intervention was 0.373 (0.204) mg kg-1. Children in the fish group had an increase in THHg (change 0.162, 95% CI 0.111, 0.213 mg kg-1), whereas children in the meat group had decreased THHg (-0.053, 95% CI -0.103, -0.002 mg kg-1). There were no notable associations between THHg and the WPPSI-III raw scores at baseline or after 16 weeks (...) for development.To measure the change in total hair mercury concentration (THHg) after an intervention of lunch meals with fatty fish or meat in Norwegian preschool children, and to examine the associations between THHg and cognitive function.Children (n = 232) 4-6 years old were randomized to lunch meals with fatty fish (n = 114) or meat (n = 118) three times a week for 16 weeks. THHg was determined using a Direct Mercury Analyzer, and cognitive function was assessed by the Wechsler Preschool and Primary

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2018 Environment international Controlled trial quality: uncertain

150. Sodium nitroprusside treatment for psychotic symptoms and cognitive deficits of schizophrenia: A randomized, double-blind, placebo-controlled trial. (PubMed)

the Wechsler Adult Intelligence Scale. Patients received two SNP or placebo infusions (0.5 μg/kg per min for 4 h) at a one-week interval. We reassessed psychiatric symptoms and cognitive functions using the same tests shortly after the first and second infusions and 4 weeks after the second infusion. We did not find any significant effect of SNP over placebo on psychotic symptoms or cognitive functions, although SNP was relatively well tolerated with a good safety profile.Copyright © 2018 Elsevier B.V. All (...) , we tested whether SNP can improve psychotic symptoms and cognitive function in schizophrenia patients with longer disease history. This was a randomized, double-blind, placebo-controlled trial conducted between May 2016 and April 2017. Forty-two schizophrenia patients aged 18-45 years were recruited from Henan Province Mental Hospital. Baseline psychiatric symptoms were measured using the Positive and Negative Syndrome Scale (PANSS), and baseline cognitive functions were measured using

2018 Psychiatry research Controlled trial quality: uncertain

151. Cadmium exposure and cognitive abilities and behavior at 10 years of age: A prospective cohort study. (PubMed)

), measured by ICP-MS. Cognitive abilities were assessed with Wechsler Intelligence Scale for Children (4th edition) and behavior with the parent-rated Strengths and Difficulties Questionnaire.In multivariable-adjusted models, urinary cadmium at 10 years was inversely associated with Full scale IQ and most of the sub-scales. Associations were mainly observed in boys, in whom the difference in Full scale IQ was 7.0 scores (95% CI: -11, -2.7), corresponding to 0.21 SD, when comparing those in the highest (...) cadmium exposure was associated with lower intelligence in boys, and there were indications of altered behavior in girls for both prenatal and childhood exposures. Findings are of concern as similar exposure levels are common world-wide.Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

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2018 Environment international Controlled trial quality: uncertain

152. Chronic administration of ellagic acid improved the cognition in middle-aged overweight men. (PubMed)

. Additionally, ellagic acid increased plasma BDNF by 21.2% in the overweight group and showed no effects on normal-weight participants. Moreover, the increased saliva cortisol level in overweight individuals was inhibited by 22.7% in a 12-week ellagic acid treatment. Also, compared with placebo, overweight individuals who consumed ellagic acid showed enhanced cognitive function as measured by the Wechsler Adult Intelligence Scale-Revised and the Montreal Cognitive Assessment. To the best of our knowledge

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2018 Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme Controlled trial quality: uncertain

153. Effect of iodine supplementation in pregnant women on child neurodevelopment: a randomised, double-blind, placebo-controlled trial. (PubMed)

in Bangalore, India, and Bangkok, Thailand, were randomly assigned (1:1) to receive 200 μg iodine orally once a day or placebo until delivery. Randomisation was done with a computer-generated sequence and stratified by site. Co-primary outcomes were verbal and performance IQ scores on the Wechsler Preschool and Primary Scale of Intelligence Third Edition (WPPSI-III) and the global executive composite score from the Behaviour Rating Inventory of Executive Function-Preschool Version (BRIEF-P) in the children (...) Effect of iodine supplementation in pregnant women on child neurodevelopment: a randomised, double-blind, placebo-controlled trial. Iodine deficiency during pregnancy might be associated with reduced intelligence quotient (IQ) score in offspring. We assessed the effect of iodine supplementation in mildly iodine-deficient pregnant women on neurodevelopment of their offspring in areas where schoolchildren were iodine sufficient.In this randomised, placebo-controlled trial, pregnant women

2018 The lancet. Diabetes & endocrinology Controlled trial quality: predicted high

154. Somatic Symptom and Related Disorders: A Treatment Group and Mixed-Methods Investigation

weeks [ Time Frame: Week 1 (prior to intervention), week 6 (post-intervention) ] Will be measured with the Wechsler Abbreviated Scale of Intelligence - 2nd Edition (copyrighted), which results in a total raw score (full scale intellectual quotient) ranging from 0-205, and is normatively scored based on respondents' age resulting in standard scores (mean = 100). Higher values indicate a higher level of intellect. Baseline performance validity [ Time Frame: Week 1 (prior to intervention) ] Measured (...) performance. Change from baseline auditory working memory at 6 weeks [ Time Frame: Week 1 (prior to intervention), week 6 (post-intervention) ] Measured with the Digit Span subtest of the Wechsler Adult Intelligence Scale - 4th Edition (copyrighted), which results in three subtests (Digit Span Forward, Digit Span Backward, and Digit Span Sequencing), each ranging from a raw score of 0-16 and scored normatively resulting in scaled score (mean = 10). Higher scores indicate better performance. Change from

2018 Clinical Trials

155. Decompressive Craniectomy for Severe Traumatic Brain Injury in Children With Refractory Intracranial Hypertension

[ Time Frame: at 1 year and 2 years after inclusion ] neuropsychological assessment at one year and at two years using the Wechsler intelligence scales. the Wechsler intelligence scales are a Intelligence Quotient tests. Five standard tests are done to evaluate: the verbal comprehension index, the fluid reasoning index, the working memory index, and the processing speed index, as well as a total Intelligence Quotient. Classification of performance for scaled index scores are as follows: Below Average (...) of the patients at 2 years [ Time Frame: two years after surgery ] Functional neurological status (equating with success of the treatment) will be measure by the Glasgow Outcomes Scale-Extended Pediatric version. Extended GOS (GOSE) provides detailed categorization into eight categories by subdividing the categories of severe disability, moderate disability and good recovery into a lower and upper category. the GOSE range from 1 to 8 (Upper Good Recovery to Death). A score from 3 defines satisfactory

2018 Clinical Trials

156. Skin Cancer Prevention With Nicotinamide in Transplant Recipients

standard deviation of Animal Naming Task scores (substudy) [ Time Frame: 1 year ] Animal Naming Task, a verbal fluency task, measures the total number of animals named in one minute, with a higher number representing better verbal fluency Pooled standard deviation of cognitive test scores (substudy) [ Time Frame: 1 year ] Wechsler Adult Intelligence Scale - Revised, Digit Span subtest, a number sequencing memory test, measures the number of correctly repeated sequences with maximum score of 48

2018 Clinical Trials

157. Working memory deficit in drug-resistant epilepsy with an amygdala lesion (PubMed)

Working memory deficit in drug-resistant epilepsy with an amygdala lesion This study compared temporal lobe epilepsy (TLE) patients with amygdala lesion (AL) without hippocampal sclerosis (HS) (TLE-AL) with patients with TLE and HS without AL (TLE-HS). Both subtypes of TLE arose from the right hemisphere. The TLE-AL group exhibited a lower Working Memory Index (WMI) on the Wechsler Adult Intelligence Scale, third edition (WAIS-III), indicating that the amygdala in the right hemisphere

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2018 Epilepsy & behavior case reports

158. Identifying Vulnerable Periods of Neurotoxicity to Triclosan Exposure in Children (PubMed)

to nine times between the second trimester of gestation and 8 y of age. The Wechsler Intelligence Scale for Children-IV [i.e., Full-Scale Intelligence Quotient (IQ)] assessment was administered to HOME Study children at 8 y of age. We estimated covariate-adjusted triclosan-IQ associations at each visit. We also tested whether associations between triclosan concentrations and cognitive test scores varied among exposure at different time periods.Full-Scale IQ was not significantly associated (...) periods for Full-Scale IQ, PRI, Verbal Comprehension Index, and Working Memory (triclosan-visit interaction p≤0.04).Urinary triclosan concentrations at delivery, but not during mid to late pregnancy and childhood, were associated with significantly lower children's cognitive test scores at 8 y of age in this cohort of U.S. children.

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2018 Environmental health perspectives

159. Preschoolers’ Technology-Assessed Physical Activity and Cognitive Function: A Cross-Sectional Study (PubMed)

the Physical Activity and Cognitive Development Study was conducted in Shanghai, China. Physical activity was measured with accelerometers for 7 consecutive days, and cognitive functions were assessed using the Chinese version of Wechsler Young Children Scale of Intelligence (C-WYCSI). Linear regression analyses were used to assess the association between physical activity and cognitive function. A total of 260 preschool children (boys, 144; girls, 116; mean age: 57.2 ± 5.4 months) were included (...) in analyses for this study. After adjusting for confounding factors, we found that Verbal Intelligence Quotient, Performance Intelligence Quotient, and Full Intelligence Quotient were significantly correlated with light physical activity, not moderate to vigorous physical activity, in boys. Standardized coefficients were 0.211, 0.218, and 0.242 (all p < 0.05) in three different models, respectively. However, the correlation between physical activity and cognitive functions were not significant in girls (p

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2018 Journal of clinical medicine

160. Arachidonic and docosahexaenoic acid status in pregnant women is not associated with cognitive performance of their children at 4 or 6 - 7 years (PubMed)

at the age of 4 years was assessed by the Wechsler Preschool and Primary Scale of Intelligence and at the age of 6-7 years by the Wechsler Abbreviated Scale of Intelligence. Executive function at the age of 6-7 years was assessed using elements of the Cambridge Neuropsychological Test Automated Battery. Neither DHA nor ARA concentrations in early or late pregnancy were associated significantly with neurocognitive function in children at the age of 4 years or the age of 6-7 years. These findings suggest

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2018 The British journal of nutrition

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