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Wechsler Intelligence Scale

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241. Efficacy and Safety Study of Gantenerumab in Participants With Early Alzheimer's Disease (AD)

in Functional Activities Questionnaire (FAQ) Score [ Time Frame: Baseline Up to Week 104 ] Change from Baseline to Week 104 in Coding [ Time Frame: Change from baseline to Week 104 in the Wechsler Adult Intelligence Scale - Fourth Edition (WAIS-IV) coding subtest. ] Change from Baseline to Week 104 in Alzheimer Disease Cooperative Study Group-Activities of Daily Living (ADCS-ADL) Total Score [ Time Frame: Baseline Up to Week 104 ] Percentage of Participants with Adverse Events [ Time Frame: Baseline up (...) Assessment Scale-Cognition, Subscale 11 (ADAS-Cog11) [ Time Frame: Baseline Up to Week 104 ] Change from Baseline to Week 104 in Mini-Mental State Examination (MMSE) Total Score [ Time Frame: Baseline Up to Week 104 ] Change from Baseline to Week 104 in Alzheimer Disease Assessment Scale-Cognition, Subscale 13 (ADAS-Cog13) [ Time Frame: Baseline Up to Week 104 ] Change from Baseline to Week 104 in Verbal Fluency Task Score [ Time Frame: Baseline Up to Week 104 ] Change from Baseline to Week 104

2018 Clinical Trials

242. Multi-dimensional Investigations of Negative Emotions and Drug-resistant Auditory Verbal Hallucinations in Psychosis

scale assessing state depression, state anxiety and state happiness will be conducted. Secondary Outcome Measures : Cognitive capacity as measured by the Wechsler Adult Intelligence Scale - IV (HK) short form (WAIS-IV) [ Time Frame: Baseline ] An instrument developed to assess cognitive ability and the relationship between intellectual functioning and memory of adults. The WAIS-IV (HK) short form includes four subscales - arithmetic, visual puzzle, information, and coding. Handedness as measured (...) related topics: related topics: Groups and Cohorts Go to Outcome Measures Go to Primary Outcome Measures : Psychotic symptomatology as measured by Positive and Negative Syndrome Scale (PANSS), Scale of Assessment for Positive Symptoms (SAPS), and the Psychotic Symptom Rating Scales (PSYRATS) [ Time Frame: Baseline ] Positive and Negative Syndrome Scale (PANSS) is an interview-based assessment of the severity of symptoms associated with schizophrenia, including positive, negative, and general

2018 Clinical Trials

243. Effect of 4-session Metacognitive Training in Chinese Adult Outpatients With Schizophrenia Spectrum Disorders and Major Depressive Disorder

containing 10 items covering state and trait anger, anxiety, curiosity and depression. Secondary Outcome Measures : Cognitive capacity as measured by the Chinese version of the Wechsler Adult Intelligence Scale - III (WAIS-III) [ Time Frame: Baseline ] Three subtest short form - vocabulary, matrix reasoning and information - will be administered at baseline to assess the participants' cognitive capacity. Severity of generalized anxiety disorder as measured by Generalised Anxiety Disorder 7 (GAD-7) [ Time (...) , most likely causal explanation to each of the hypothesized situations, and then to categorize this cause as being internal, external-personal or external-situational. Psychotic symptomatology as measured by Positive and Negative Syndrome Scale (PANSS) [ Time Frame: 6 months ] Positive and Negative Syndrome Scale (PANSS) is an interview-based assessment of the severity of symptoms associated with schizophrenia, including positive, negative, and general psychopathology. Depressive symptomatology

2018 Clinical Trials

244. Mindfulness-Based Stress Reduction (MBSR) and Transcranial Direct Current Stimulation (tDCS)

software, participation in psychotherapy or regular engagement in mindfulness practice and/or yoga. Taking anticonvulsant or antipsychotics that cannot be safely tapered and discontinued. Significant neurological condition (e.g. stroke, seizure disorder, multiple sclerosis). A pace-maker or other metal implants that would preclude safe use of tDCS. Intelligence Quotient (IQ) < 70 as estimated by the Wechsler Test of Adult Reading. Contacts and Locations Go to Information from the National Library (...) : Baseline, Approximately 10-14 weeks after baseline ] Change in anxiety symptoms as assessed by Patient-Reported Outcomes Measurement Information System (PROMIS) anxiety symptoms [ Time Frame: Baseline, Approximately 10-14 weeks after baseline ] Change in quality of life as assessed by PROMIS Scale for Ability to Participate in Social Roles and Activities, the PROMIS Scale for Satisfaction with Social Roles and Activities and the [ Time Frame: Baseline, Approximately 10-14 weeks after baseline ] Change

2018 Clinical Trials

245. State and Trait Mediated Response to TMS in Substance Use Disorder

and learning disabilities may be associated with altered brain functioning in regions recruited during laboratory task performance. Cognitive impairment may affect one s ability to give informed consent. Assessment tool: Medical History and Wechsler Abbreviated Scale of Intelligence (WASI). IQ estimate must be 80 or over. Have coagulopathies, history of, current superficial, or deep vein thrombosis, musculoskeletal abnormalities restricting an individual s ability to lie flat for extended periods of time (...) not explicitly described in this criterion. Justification: Psychiatric disorders involve the central neural system (CNS) and, therefore, can be expected to alter the fMRI measures being used in this study. Assessment tools: M.I.N.I., Beck Depression Inventory, Beck Anxiety Inventory, Adult ADHD Self-Report Scales and clinical terview confirmation by clinician. Meet current DSM-5 criteria for moderate to severe substance use disorder, for alcohol or any drug (except nicotine for the smoker group). Past

2018 Clinical Trials

246. Sodium nitroprusside treatment for psychotic symptoms and cognitive deficits of schizophrenia: A randomized, double-blind, placebo-controlled trial. (PubMed)

the Wechsler Adult Intelligence Scale. Patients received two SNP or placebo infusions (0.5 μg/kg per min for 4 h) at a one-week interval. We reassessed psychiatric symptoms and cognitive functions using the same tests shortly after the first and second infusions and 4 weeks after the second infusion. We did not find any significant effect of SNP over placebo on psychotic symptoms or cognitive functions, although SNP was relatively well tolerated with a good safety profile.Copyright © 2018 Elsevier B.V. All (...) , we tested whether SNP can improve psychotic symptoms and cognitive function in schizophrenia patients with longer disease history. This was a randomized, double-blind, placebo-controlled trial conducted between May 2016 and April 2017. Forty-two schizophrenia patients aged 18-45 years were recruited from Henan Province Mental Hospital. Baseline psychiatric symptoms were measured using the Positive and Negative Syndrome Scale (PANSS), and baseline cognitive functions were measured using

2018 Psychiatry research

247. Clinical effects of repetitive transcranial magnetic stimulation combined with atomoxetine in the treatment of attention-deficit hyperactivity disorder. (PubMed)

of People's Liberation Army of China. These patients were randomly assigned to three groups according to treatment method: the rTMS group, the ATX group, and the rTMS+ ATX group. Before treatment and 6 weeks after treatment, clinical symptoms and executive functions of ADHD patients were evaluated with the Swanson, Nolan, and Pelham, Version IV (SNAP-IV) Questionnaire, continuous performance test, three subtests (arithmetic, digit span, and coding) of Wechsler Intelligence Scale for Children, as well (...) as Iowa Gambling Tasks (IGT). The effects of treatment were compared among three groups.After 6 weeks of treatment, the scores of all factors in the SNAP-IV questionnaire were lower than those before treatment in the three groups; the scores of three subtests of Wechsler Intelligence Scale for Children, continuous performance test, and IGT were also significantly higher than those before treatment. The rTMS+ ATX group had a better improvement in attention deficits and hyperactivity impulse on the SNAP

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2018 Neuropsychiatric disease and treatment

248. Fatty fish, hair mercury and cognitive function in Norwegian preschool children: Results from the randomized controlled trial FINS-KIDS. (PubMed)

Intelligence Scale-III (WPPSI-III) pre- and post-intervention. Linear mixed effect models were used to analyze changes in THHg and WPPSI-III scores.The mean (SD) THHg pre-intervention was 0.373 (0.204) mg kg-1. Children in the fish group had an increase in THHg (change 0.162, 95% CI 0.111, 0.213 mg kg-1), whereas children in the meat group had decreased THHg (-0.053, 95% CI -0.103, -0.002 mg kg-1). There were no notable associations between THHg and the WPPSI-III raw scores at baseline or after 16 weeks (...) for development.To measure the change in total hair mercury concentration (THHg) after an intervention of lunch meals with fatty fish or meat in Norwegian preschool children, and to examine the associations between THHg and cognitive function.Children (n = 232) 4-6 years old were randomized to lunch meals with fatty fish (n = 114) or meat (n = 118) three times a week for 16 weeks. THHg was determined using a Direct Mercury Analyzer, and cognitive function was assessed by the Wechsler Preschool and Primary

2018 Environment international

249. Does Decreased Surgical Stress Really Improve the Psychosocial Health of Early-Onset Scoliosis Patients? A Comparison of Traditional Growing Rods and Magnetically-Controlled Growing Rods Patients Reveals Disappointing Results. (PubMed)

treatment has had positive clinical and radiographic results; however, upwards of 10 surgical sessions and high complication rates have called into question the quality of life of these children. Improvement with the introduction of the MCGR is expected.GR patients with minimum of 2-years follow-up were recruited. None had neurological conditions. All underwent testing with the Wechsler Intelligence Scale for Children-Revised, and only those in the normal range were included. Patients filled out

2018 Spine

250. Temporal Aspects of Memory: A Comparison of Memory Performance, Processing Speed and Time Estimation Between Young and Older Adults (PubMed)

young and older adult groups on both classical memory tasks including auditory and visual digit spans, N-back, Wechsler Adult Intelligence Scale (WAIS)-based measures of processing speed (i.e., Symbol Search [SS] and Coding [Cod]) and a temporal measure of WM with a focus on retrospective time estimation. Our sample included 66 university students (58 F, 8 M) between the ages of 18-29, and 33 university-educated healthy older adults (25 F, 8 M) between the ages of 60-81. Results indicated that older

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2018 Frontiers in aging neuroscience

251. Modality-Specific Working Memory Systems Verified by Clinical Working Memory Tests (PubMed)

Adult Intelligence Scale-IV and Korean version of Wechsler Memory Scale-IV were administered to assess WM. Confirmatory factor analysis (CFA) was used to observe whether WM measures fit better to a one-factor or two-factor model.CFA results demonstrated that a two factor model fits the data better than one-factor model as expected.Our study supports a modality model of WM, or the existence of modality-specific WM systems, and thus poses a clinical significance of assessing both auditory and visual (...) Modality-Specific Working Memory Systems Verified by Clinical Working Memory Tests This study was to identify whether working memory (WM) can be clearly subdivided according to auditory and visual modality. To do this, we administered the most recent and universal clinical WM measures in a mixed psychiatric sample.A total of 115 patients were diagnosed on the basis of DSM-IV diagnostic criteria and with MINI-Plus 5.0, a structured diagnostic interview. WM subtests of Korean version of Wechsler

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2018 Clinical Psychopharmacology and Neuroscience

252. A comparison of three-factor structure models using WISC-III in Greek children with learning disabilities (PubMed)

A comparison of three-factor structure models using WISC-III in Greek children with learning disabilities Children with learning disabilities are a heterogeneous group of children with a common characteristic discrepancy on the progress and development of their individual learning abilities. A few statistical analyses have been published regarding the factor analysis of the Greek Edition of Wechsler Intelligence Scale for Children-III. The aim of the research is the emergence of a new factorial (...) . The Wechsler Intelligence Scale for Children-Third Edition was used to assess children's cognitive function. Using multi-factor analysis, three alternative factor models were compared.Analysis of factor structure models suggests a new bi-factorial model that more appropriately describes the areas of cognitive development of children with learning disabilities. The first factor includes Comprehension, Picture Arrangement, Coding, Block Design, and Object Assembly, whereas the second one combines Information

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2018 Annals of general psychiatry

253. Improvement of intellectual outcomes in 20 children with refractory epilepsy after individualized surgery (PubMed)

to evaluate seizure control and the Wechsler Intelligence Scale for Children, fourth edition (WISC-IV), to test the children's intellectual outcomes 7-day preoperative and 3-, 6-, and 12-month postoperative.In total, 14 cases were seizure free (Engel I) and 2 cases to have suffered few attacks since surgery (Engel II). In two cases, the frequency of seizures decreased by >90% (Engel III). In the remaining two cases, the effects of surgery on seizure control were not obvious (Engel IV). All children (...) Improvement of intellectual outcomes in 20 children with refractory epilepsy after individualized surgery Refractory epilepsy is a common and troublesome neurosurgical disease. This study is designed to compare seizure control and degrees in intellectual outcome in children with refractory epilepsy after surgical treatment.20 children with refractory epilepsy were treated with tailored epilepsy surgery or vagus nerve stimulation (VNS). We used the Engel Epilepsy Surgery Outcome Scale

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2018 Surgical neurology international

254. Child Neurodevelopmental Outcomes by Prepregnancy Body Mass Index and Gestational Weight Gain. (PubMed)

was categorized as normal (18.5-24.9), overweight (25.0-29.9), or obese (30 or greater). We also evaluated early (20 weeks of gestation or less), late (greater than 20 weeks of gestation), and total gestational weight gain and categorized gestational weight gain as inadequate, adequate, and excessive per 2009 Institute of Medicine guidelines. Neurodevelopmental outcomes included 5-year Wechsler Preschool and Primary Scale of Intelligence and 3-year Differential Ability Scales-II. Linear and logistic (...) of gestational weight gain, respectively. Maternal differences among the BMI categories included race-ethnicity, education, insurance type, parity, and thyroid status (all P<.01), whereas the gestational weight gain groups only differed by parity (P<.001). In unadjusted analysis, children of obese (93.2±12.8; 88.5±13.3) and overweight (94.1±15.6; 89.6±16.0) women had lower Wechsler Preschool and Primary Scale of Intelligence and Differential Ability Scales-II scores, respectively, than normal-weight women

2018 Obstetrics and Gynecology

255. Local structural connectivity is associated with social cognition in autism spectrum disorder. (PubMed)

Wechsler Adult Intelligence Scale IV (WAIS-IV), Communication Checklist-Adult, Empathy Quotient, Social Responsiveness Scale and Behaviour Rating Inventory of Executive Function-Adult (BRIEF-A). In contradiction with the models of short-range over-connectivity in autism spectrum disorder, we found that patients with autism spectrum disorder had a significantly decreased anatomical connectivity in a component comprising 13 short tracts compared to controls. Specific short-tract atypicalities in temporal

2018 Brain

256. Cognition, health-related quality of life and psychosocial functioning after GH/GnRHa treatment in young adults born SGA. (PubMed)

, dose-response GH study until AH involving 99 adolescents born SGA, of whom 61 children received 2 additional years of GnRHa treatment. At AH, the Wechsler Adult Intelligence Scale and TNO-AZL Adults Quality of Life questionnaire were administered to the study group. Additionally, the study group and 67 adolescents born SGA (19 GnRHa) from a second study group completed the Self-Perception Profile of Adolescents and Child/Adolescent Behavior Checklist at AH. Scores in GH-treated young adults (...) with GnRHa treatment (GH/GnRHa group) were compared with GH-treated adolescents without GnRHa treatment (GH group) and a reference population.Mean age (SD) at AH was 17.5 (1.2) and 17.4 (1.4) years in the GH/GnRHa and GH group, respectively. Intelligence quotient scores were similar in GH/GnRHa and GH groups (96.33 vs 92.47). HRQoL was similar between both groups and also when compared with the reference population, but the GH/GnRHa group had a significantly lower perception of cognitive functioning

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2018 Journal of Clinical Endocrinology and Metabolism

257. Further Evidence of Morbidity and Dysfunction Associated With Subsyndromal ADHD in Clinically Referred Children. (PubMed)

placed in a special class; and scores on 4 of the 5 Wechsler Intelligence Scale for Children-Revised Version subscales (excluding Digit Span) as well as in Freedom from Distractibility Index score (P < .001). Subthreshold and full ADHD subjects had similarly elevated Global Assessment of Functioning scores versus controls (P < .001), but subjects with subthreshold ADHD had fewer perinatal complications and better family functioning scores and were more likely to be female and older and to come from (...) at onset of < 12 years, while 79% would have maintained their subthreshold diagnoses. Subjects with subthreshold ADHD differed from controls in the mean number of comorbid disorders; rates of mood, anxiety, and elimination disorders (all P < .001) and substance use disorders (P < .05); scores on all Child Behavior Checklist clinical and social functioning scales; scores on 7 of the 10 Social Adjustment Inventory for Children and Adolescents scales; rates of requiring extra help in school and being

2018 Journal of Clinical Psychiatry

258. Role of frontal white matter and corpus callosum on social function in schizophrenia. (PubMed)

of regions of interest and social function in schizophrenia. A total of 149 patients with schizophrenia and 602 healthy comparison subjects (HCS) underwent DTI and completed the Picture Arrangement subtest of the Wechsler Adult Intelligence Scale-Third Edition and the Finance subscale of the University of California, San Diego, Performance-Based Skills Assessment Brief, as social indices of interest. The fractional anisotropy (FA) in the anterior corona radiata and corpus callosum was significantly lower (...) Role of frontal white matter and corpus callosum on social function in schizophrenia. Patients with schizophrenia show severe impairment in social function and have difficulty in their daily social life. Although a recent large-scale multicenter study revealed alterations in white matter microstructures, the association between these anatomical changes and social dysfunction in schizophrenia remains unknown. Therefore, we investigated the association between the white matter integrity

2018 Schizophrenia Research

259. Relationship between working memory and comprehension and expression of grammar in Farsi-speaking children with cochlear implants. (PubMed)

skills in children with CIs.The sample consisted of 20 Farsi-speaking children with CIs. WM was estimated by forward and backward auditory digit spans (FBS and BDS) from the Persian (Farsi) version of the Wechsler Intelligence Scale for Children, 4th edition. The comprehension of grammar by participants was evaluated using the Persian Syntax Comprehension Test. Grammar expression was assessed using the Photographic Expressive Persian Grammar Test. Pearson's correlation and simple linear regression

2018 International Journal of Pediatric Otorhinolaryngology

260. IQ discrepancy differentiates levels of fine motor skills and their relationship in children with autism spectrum disorders (PubMed)

standard deviation (1SD; EVENIQ; n=81), discrepantly higher verbal intelligence quotient (VIQ; n=22; VIQ>performance intelligence quotient [PIQ] above 1SD [≥15 points]), and discrepantly higher PIQ (n=24; PIQ>VIQ above 1SD [≥15 points]). Children's IQD and motor skills were determined with the Wechsler Preschool and Primary Scale of Intelligence™ - Fourth Edition and the motor subtests of the Comprehensive Developmental Inventory for Infants and Toddlers (CDIIT), respectively.One-way analysis (...) IQ discrepancy differentiates levels of fine motor skills and their relationship in children with autism spectrum disorders We investigated 1) the impact of differences in intelligence quotient discrepancy (IQD) on motor skills of preschool-aged children with autism spectrum disorders (ASD); 2) the relationships between IQD and motor skills in preschool-aged children with ASD.A total of 127 ASD preschool-aged children were divided into three groups according to the size of the IQD: IQD within 1

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2018 Neuropsychiatric disease and treatment

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