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Wechsler Intelligence Scale

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221. Acute Effects of Exercise in College Students With ADHD

at each experimental appointment over a period of two weeks ] The Digit Span (Wechsler, 2008) subtest of the Wechsler Adult Intelligence Scale (WAIS-IV) is an auditory working memory task. The researcher will say numbers aloud at a rate of one number per second. The participant will be tasked with remembering and repeating the numbers in a prescribed (forward, backward, sequencing) order. Participants will complete the Digit Span (forward, backward and sequencing) auditory working memory task at each (...) experimental appointment. For the SIT appointment, participants will complete the Digit Span (forward, backward and sequencing) tasks approximately 15 minutes after exercise termination. Change in Letter-Number Sequencing from appointment 1 to 2 [ Time Frame: Completed at each experimental appointment over a period of two weeks ] The Letter-Number Sequencing (Wechsler, 2008) task is a supplemental subtest of the Wechsler Adult Intelligence Scale (WAIS-IV) that measures auditory working memory. Researchers

2018 Clinical Trials

222. Cross-sex Hormone Therapy and Neuronal Plasticity

magnetic resonance imaging Glutamate concentration in the anterior cingulate cortex and left dorsolateral prefrontal cortex [ Time Frame: 90 days ] Proton spectroscopy - magnetic resonance imaging; Glutamate concentration in the left dorsolateral prefrontal cortex will be correlated to over all measures of cognition and executive functioning. Cognition [ Time Frame: 90 days ] Instrument: Wechsler Adult Intelligence Scale (WAIS) version 3. Subscale: Full Scale Intelligence coefficient. Mean: 100 (...) Standard deviation (SD):15 for Brazilian population. Range of classification: 69 and below - Extremely Low 70-79 - Borderline 80-89 - Low Average 90-109 - Average 110-119 - High Average 120-129 - Superior 130 and above - very superior Operational memory [ Time Frame: 90 days ] Subscale from Wechsler Adult Intelligence Scale (WAIS) version 3. Mean: 100 Standard deviation (SD):15 for Brazilian population. 69 and below - Extremely Low 70-79 - Borderline 80-89 - Low Average 90-109 - Average 110-119 - High

2018 Clinical Trials

223. Efficacy Study of Deep Brain Stimulation in Patients With Treatment Resistant Major Depression

Assessments: Wechsler Adult Intelligence Scale (WAIS) (vocabulary, similarities) [ Time Frame: at 6 months DBS compared to baseline and at end of the study compared to baseline, assessed up to 77 weeks ] see above Neuropsychological Assessments: Mini-Mental-Status-Test (MMST) [ Time Frame: at 6 months DBS compared to baseline and at end of the study compared to baseline, assessed up to 77 weeks ] see above Neuropsychological Assessments: Multiple-Choice Vocabulary Intelligence Test (MWT-B) [ Time Frame (...) Intelligence Scale (WAIS) (vocabulary, similarities) [ Time Frame: at 4 months after implantation ] Score range "vocabulary": 0-32, Score range "finding similarities": 0-32, higher scores indicate better cognitive performance Neuropsychological Assessments: Mini-Mental-Status-Test (MMST) [ Time Frame: at 4 months after implantation ] Score range 0-30, higher scores indicate better cognitive performance Neuropsychological Assessments: Multiple-Choice Vocabulary Intelligence Test (MWT-B) [ Time Frame: at 4

2018 Clinical Trials

224. IVF Offspring Born in Guangzhou

: At age of 6 years old ] Assessed using Wechsler's Intelligence Scale of Children (WISC) including verbal test and performance test.Intelligence quotient ranges from 40 to 160, in which under 70 is defined as mental retardation Secondary Outcome Measures : Prevalence of gestational diabetes, pregnancy induced hypertension, and cesarean section [ Time Frame: From 20 weeks of gestation to delivery ] Assessed by self-reported time of onset and electronic medical records Prevalence of stillbirth, preterm (...) Go to Layout table for study information Study Type : Observational Estimated Enrollment : 3000 participants Observational Model: Cohort Time Perspective: Prospective Official Title: IVF Offspring Born in Guangzhou Cohort Study Actual Study Start Date : February 1, 2012 Estimated Primary Completion Date : December 31, 2019 Estimated Study Completion Date : December 31, 2038 Groups and Cohorts Go to Outcome Measures Go to Primary Outcome Measures : Intelligence quotient of offspring [ Time Frame

2018 Clinical Trials

225. Probiotics to Treat "Inflammatory Depression"

6 different domains, ranging from 0-144. Generalized Anxiety Disorder-7 (GAD-7) [ Time Frame: 8 weeks ] Total Composite score of 7 items, measuring anxiety symtoms, ranging from 0-21. Insomnia Severity Index (ISI) [ Time Frame: 8 weeks ] Total Composite score of 7 items, ranging from 0-28 Fatigue Severity Scale (FSS) [ Time Frame: 8 weeks ] Total Composite score of 9 items, measuring severity of fatigue, ranging from 1-63 Wechsler Adult Intelligence Scale (WAIS-IV) [ Time Frame: 8 weeks ] Two (...) Intervention Model: Parallel Assignment Intervention Model Description: Intervention will be add-on specific probiotic to ongoing treatment with antidepressant medication or Cognitive Behavioral Therapy (CBT). Subjects will be randomized to placebo or probiotic. To assure a balanced subject recruitment, block randomization within strata (ongoing treatment with CBT, antidepressant or both) will be performed. Blood sampling and symptom rating scales will be completed at baseline, at weeks 4 and 8 (end

2018 Clinical Trials

226. A Study of the Impact of Hemophilia and Its Treatment on Brain Development, Thinking and Behaviour in Children With Hemophilia

of Executive Function (BRIEF) [ Time Frame: Day 1 ] Normalized score compared to US population (0 = equivalent to US average, negative = below US average, positive = above US average Attention and processing speed (full scale IQ) according to Wechsler Preschool and Primary Scale of Intelligence-4th Edition (WPPSI-IV) for age group 4-6 years or Wechsler Abbreviated Scale of Intelligence, 2nd Edition (WASI-II) for age group 7-22 years [ Time Frame: Day 1 ] Normalized score compared to US population (0 (...) of development and intelligence for about 40-45 minutes and adolescents and young adults (age 11-21) with hemophilia able and willing to complete additional self-assessment scales for about 30-45 minutes during comprehensive or other elective visit for in English or Spanish (depending on age group) - Provision of informed consent before the start of any study-related activities Exclusion Criteria: - Patient aged 3:7-3:11 years (43-47 months) - Prior participation in the study - Prior neurocognitive screening

2018 Clinical Trials

227. Mucopolysaccharidosis Type II Natural History

(LIPS), any version Mullen Scales of Early Learning (MSEL), any version Vineland Adaptive Behavior Scales (VABS), any version Wechsler Intelligence Scale for Children (WISC), any version Wechsler Preschool and Primary Scale of Intelligence (WPPSI), any version If the subject has undergone hematopoietic stem cell transplantation (HSCT), they must have at least one neurocognitive assessment prior to HSCT. Contacts and Locations Go to Information from the National Library of Medicine To learn more (...) in medical chart. [ Time Frame: Up to 10 years old ] There are 10 neurocognitive measures that provide intelligence quotients (IQ) scores and/or developmental quotients (DQ) scores. Secondary Outcome Measures : Prevalence of general organ involvement and specific characteristics of severe MPS II as documented in medical chart. [ Time Frame: Up to 10 years old ] Documentation in medical chart regarding date and age of onset of: Disease Characteristics, General Appearance, Neurologic/Psychiatric

2018 Clinical Trials

228. Determining Whether Multiple Anesthesia Exposures Affect Cognitive Function for Retinoblastoma Patients

with brain development in children who have never had anesthesia. Condition or disease Intervention/treatment Pediatric Retinoblastoma Retinoblastoma Other: Wechsler Intelligence Scale for Children, Fifth Edition (WISC-V) Other: California Verbal Learning Test, Children's Version Other: Beery Developmental Test of Visual Motor Integration, 6th edition Other: Grooved Pegboard Test Other: Behavior Assessment System for Children/Parent Report Study Design Go to Layout table for study information Study Type (...) : Other: Wechsler Intelligence Scale for Children, Fifth Edition (WISC-V) the WISC-V assessment produces a Full Scale IQ (FSIQ) used for primary power consideration in this study. The FSIQ is the most comprehensive global ability score on the WISC-V, and it has been conventionally reported and interpreted as an estimation of overall intellectual ability Other: California Verbal Learning Test, Children's Version Used to assess verbal learning and memory in children and adolescents Other: Beery

2018 Clinical Trials

229. SSM vs HEP in Late-Life Depression

(MoCA; London only) [ Time Frame: 0 weeks (baseline); 12 weeks; and 26 weeks ] The MoCA is a brief 30-item measure of different cognitive abilities (e.g. visuospatial ability, short-term memory). Scores range from 0-30, with scores above 26 indicating normal cognitive functioning. Wechsler Adult Intelligence Scale (WAIS-IV) -Test of premorbid functioning [ Time Frame: 0 weeks (baseline); 12 weeks; and 26 weeks ] WAIS-IV-Test of premorbid functioning is a test that assesses cognitive and memory (...) functioning. Performance on this test will be used to estimate a participant's Intelligence Quotient. Wechsler Adult Intelligence Scale (WAIS-IV)-Digit Span [ Time Frame: 0 weeks (baseline); 12 weeks; and 26 weeks ] WAIS-IV-Digit Span is an attention span task involving repeating digits in forward order, backward order, as well as sequencing digits in mind. Delis-Kaplan Executive Function System (D-KEFS) Color Word Test Conditions 1-3 [ Time Frame: 0 weeks (baseline); 12 weeks; and 26 weeks ] D-KEFS Color

2018 Clinical Trials

230. A Study of Identity Building in Children With ADHD

: baseline ] The Global Assessment of Functioning (GAF) is a numeric scale used by mental health clinicians and physicians to rate subjectively the social, occupational, and psychological functioning of an individual, e.g., how well one is meeting various problems-in-living. Scores range from 100 (extremely high functioning) to 1 (severely impaired). working memory [ Time Frame: baseline ] memory of numbers, memory of images in Wechsler Intelligence Scale for Children 5 executive functions [ Time Frame (...) the Damon and Hart's Self-Understanding Interview, exploring 7 identity domains: Physical, Active, Social, Psychological, Continuity, Agentivity, Distinction Self/Other. The severity of ADHD, neuropsychological functioning (attention, working memory, executive functions, long-term memory), self-esteem and internal/external attributive style (locus of control) will be assessed by validated scales. The overall level of identity development and in each dimension will be compared between patients

2018 Clinical Trials

231. RGX-111 Gene Therapy in Patients With MPS I

] Change from baseline in neurodevelopment [ Time Frame: Baseline, Week 24, Week 52 , Week 104 ] Change from baseline in neurodevelopment parameters of IQ as measured by the Wechsler Abbreviated Scale of Intelligence, 2nd Edition (WASI-II). Change from baseline in neurodevelopment [ Time Frame: Baseline, Week 24, Week 52 ] Change from baseline in neurodevelopment parameters of attention as measured by the Tests of Variables of Attention, Version 9 (TOVA). Eligibility Criteria Go to Information from

2018 Clinical Trials

232. Pre-Clinical White Matter Changes and Associated Connectivity Effects in Fabry Disease

fast bound-pool fraction imaging (FBFI), which is a technique better suited to capture and quantify these lesions, to study these lesions in patients with FD. In parallel, we would like to use functional MRI (fMRI) to study how these lesions alter brain function and connectivity in FD. Neuropsychological assessements will include Wechsler Adult Intelligence Scale, WAIS-III (Digit Span, Symbol-Digit/Coding, and Symbol Search), the Connors Continous Performance text (CPT-II). The Health Questionnaire (...) form, the Center for Epidemiologic Studies Depression Scale (CES-D), the RAND 36-Item Health Survey. Other Names: fmri FBFI Neuropsychological assessments Outcome Measures Go to Primary Outcome Measures : FBFI MRI using advanced MRI technique [ Time Frame: 6 months after enrollment closes ] advanced quantitative MRI technique (FBFI) to detect and quantify brain lesion in patients with FD Identify difference between patients with Fabry disease and healthy controls in brain function as measured

2018 Clinical Trials

233. Feasibility and Acceptability of a Physical Activity Behavior Change Intervention for Parkinson's Disease

back to chair. Time to complete is recorded Change from Baseline 6 minute walk test at 4 months [ Time Frame: baseline and 4 months ] Assesses the distance walked over 6 minutes as a sub-maximal test of aerobic capacity/endurance. Change from Baseline Brunel Lifestyle Inventory at 4 months [ Time Frame: baseline and 4 months ] The Brunel lifestyle inventory is a 10-item questionnaire that measures both pre-planned and un-planned lifestyle PA Change from Baseline Wechsler Adult Intelligence Scale (...) by 4 questions, except for introjected regulation which has 3. Questions are scored using a 5-point Likert scale; Answers range from 0 (not true for me) to 4 (very true for me). Subscale scores (sum totals of the 3 or 4 questions) will be reported and compared across participants. Subscales have a maximum score of 16 (12 for introjected regulation) and a minimum score of 0. An overall score (RAI-score, Relative Autonomy Index) for motivation quality will also be constructed. This is done

2018 Clinical Trials

234. Clinical Trial of The Boosting Effect of Transcranial Random Noise Stimulation (tRNS) in Cognitive Rehabilitation of Patients With Traumatic Brain Injury

from the Wechsler Adult Intelligence Scale [ Time Frame: 1 day ] To improve performance in span of immediate verbal recall after receiving experimental intervention. Digit Span Backward from the Wechsler Adult Intelligence Scale [ Time Frame: 1 day ] To improve performance in working memory after receiving experimental intervention. Rey Auditory Verbal Learning Test [ Time Frame: 1 day ] To improve performance in short-term, long-term and recognition. Letters and Numbers from the Wechsler Adult (...) Intelligence Scale [ Time Frame: 1 day ] To improve performance in working memory after receiving experimental intervention. Spanish phonemic fluency test (PMR) [ Time Frame: 1 day ] To improve performance in phonemic fluency after receiving experimental intervention. Secondary Outcome Measures : Trail Making Test A (TMT-A) [ Time Frame: 1 day ] To improve performance in visual attention Trail Making Test B (TMT-B) [ Time Frame: 1 day ] To improve performance in task-switching Wisconsin Card Sorting Test

2018 Clinical Trials

235. Efficacy of Light Therapy Device LUMINETTE® in Major Depressive Disorder

cognitive impairment Stroop test [ Time Frame: week 10 ] test assessing the ability to inhibit cognitive interference Trail Making Test (TMT) [ Time Frame: week 10 ] test evaluating executive functions Wechsler Adult Intelligence Scale subtest (WAIS) [ Time Frame: week 10 ] test evaluating memory Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about (...) weeks. Device: placebo light therapy placebo portable light visor device Outcome Measures Go to Primary Outcome Measures : Montgomery-Åsberg depression rating scale (MADRS) [ Time Frame: week 8 ] Rating scale measuring depressive symptoms. Each item is scored from 0 to 3, yielding a total between 0 and 27. Secondary Outcome Measures : Pittsburgh Sleep Quality Index (PSQI) [ Time Frame: week 8 ] Self reported rating scale measuring quality of sleep Epworth Sleepiness Scale (ESS) [ Time Frame: week 8

2018 Clinical Trials

236. Assessment and Treatment of Cognitive Functioning Deficits in Veterans With PTSD

. Total score ranges from 0-80. Higher scores represent better outcomes. Wechsler Adult Intelligence Scale (WAIS-IV) Digit Span & Coding subtests (Wechsler, 2008) [ Time Frame: change from baseline to 3 and 6 months ] attention, working memory, processing speed, reliable digit span validity. Higher scores represent better outcomes. Scores on each subtest range from 0-18 and are reported as WAIS Scaled Scores. Controlled Oral Word Association Test (Benton, Hamsher, & Sivan, 1983) [ Time Frame: change (...) cognitive rehabilitation intervention for Veterans with a history of brain injury, but VA clinicians need data on its effectiveness for Veterans with PTSD-related cognitive functioning deficits. These studies will provide the data necessary for a larger scale RCT proposal if results show that CCT is as promising as expected for Veterans with PTSD. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 36 participants Allocation

2018 Clinical Trials

237. Metformin for Motor and Cognitive Improvement in Children With Cerebral Palsy: A Feasibility Study

. As such, for this study, children between 5.0 to 6.5 years of age will not complete the CAVLT-2. Wechsler Scales of Intelligence [ Time Frame: Change in Wechsler Scales of Intelligence measures from baseline to 40 weeks ] The Wechsler Scales of Intelligence provide a brief measure of overall intelligence. WASI-II is applicable for people aged 6.0 to 90.11 years of age. For participants who are 5.0 to 5.9 years of age, the Wechsler Preschool and Primary Scale of Intelligence - Fourth Edition (WPPSI - IV) will be used (...) of the GMFM: the original 88-item GMFM, which yields a total score and scores in five dimensions (lying & rolling, sitting, crawling & kneeling, standing, walking, running & jumping); and the GMFM-66 (66 of the 88 items) with interval scaling. Individual items on the GMFM are scored on a 4-point ordinal scale; 1 indicates that the child initiates the task (completes < 10% of the activity); 2 indicates that the child partially completes the task (completes from 10 to 99% of the activity); 3 indicates

2018 Clinical Trials

238. Active School. A School-based Intervention to Increase Childrens Daily Physical Activity Level.

. Working memory [ Time Frame: 8 months intervention ] Working memory was tested by the Wechsler Adult Intelligence Scale (WAIS)-IV-test, a forward and backward digit span, a test that measures working memory function. The measure was the length of the correct series of numbers repeated by the participant. was included Cognitive flexibility [ Time Frame: 8 months intervention ] Cognitive flexibility was tested by two tests. First the participants were asked to list all the animals they could think (...) was measured by the Child Behavior Rating Scale. Condition or disease Intervention/treatment Phase Physical Activity Aerobic Fitness Executive Function Behavioral: Physical activity Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 449 participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Prevention Official Title: Active School. A School-based Intervention to Increase

2018 Clinical Trials

239. Biomarker Research in ADHD: the Impact of Nutrition

intervention (i.e. at the end of week 2 and at the end of week 8) ] The child will type each stool using the modified Bristol stool scale form for children, which comprises 5 stool form types described and depicted in drawings. Other Outcome Measures: IQ-score [ Time Frame: At the screening session, prior to inclusion of participant in the study ] If no intelligence quotient (IQ) test has been conducted in the past year, an abbreviated form of the Wechsler Intelligence Scale III IQ test will be conducted (...) and noradrenaline precursors phenylalanine and tyrosine. Change in ADHD symptom scores [ Time Frame: Before and at the end of the FFD intervention (i.e. at the end of week 2 and at the end of week 8) ] ADHD symptoms will be scored using the 18-item ADHD rating scale, which is based on the Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV and consists of 9 items that assess inattention and 9 items that focus on hyperactivity and impulsivity. Secondary Outcome Measures : Change in whole brain neural

2018 Clinical Trials

240. Safety and Efficacy Study of Gantenerumab in Participants With Early Alzheimer's Disease (AD)

From Baseline to Week 104 in Functional Activities Questionnaire (FAQ) Score [ Time Frame: Baseline to Week 104 ] Change From Baseline to Week 104 in Coding [ Time Frame: Change from baseline to Week 104 in the Wechsler Adult Intelligence Scale - Fourth Edition (WAIS-IV) coding subtest. ] Change From Baseline to Week 104 in Alzheimer Disease Cooperative Study Group-Activities of Daily Living (ADCS-ADL) Total Score [ Time Frame: Baseline up to Week 104 ] Percentage of Participants With Adverse (...) in Alzheimer Disease Assessment Scale-Cognition Subscale 11 (ADAS-Cog11) Subscale Score [ Time Frame: Baseline up to Week 104 ] Change From Baseline to Week 104 in Mini-Mental State Examination (MMSE) Total Score [ Time Frame: Baseline up to Week 104 ] Change from Baseline to Week 104 in Alzheimer Disease Assessment Scale-Cognition, Subscale 13 (ADAS-Cog13) [ Time Frame: Baseline up to Week 104 ] Change From Baseline to Week 104 in Verbal Fluency Task Score [ Time Frame: Baseline up to Week 104 ] Change

2018 Clinical Trials

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