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Wart Treatment

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161. Interferon for the treatment of genital warts: a systematic review

Interferon for the treatment of genital warts: a systematic review Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2009 DARE.

162. High prevalence of cutaneous warts in elementary school children and ubiquitous presence of wart-associated HPV on clinically normal skin. (Abstract)

High prevalence of cutaneous warts in elementary school children and ubiquitous presence of wart-associated HPV on clinically normal skin. One-third of Dutch primary school children have cutaneous warts; each year around 20% of them seek medical treatment. However, little is known about the epidemiology of the types of human papillomavirus (HPV) causing these warts.To investigate the distribution of cutaneous wart-associated HPV types in three primary school classes by analysing skin swabs (...) taken from warts, and the forehead, hand dorsum and sole of the foot of included children.Using the hyperkeratotic skin lesion polymerase chain reaction/multiplex genotyping assay, each swab sample was used to genotype for 23 cutaneous wart-associated HPV types.Thirty-one (44%) of the 71 children had a total of 69 warts, with a maximum of six warts per child. In the wart swabs, HPV2, HPV27 and HPV57, members of Alphapapillomavirus species 4, were most frequently detected (27%, 32% and 14

2014 British Journal of Dermatology

163. Efficacy of Myrtus communis L. and Descurainia sophia L. Versus Salicylic Acid for Wart Treatment Full Text available with Trip Pro

Efficacy of Myrtus communis L. and Descurainia sophia L. Versus Salicylic Acid for Wart Treatment Wart is a skin disease with circular appendages, which is called "suloul" in Iranian traditional medicine (ITM). According to ITM literature, warts have different types and causes. The most important mechanism is excretion of materials (Khelt) from body to skin and mucus; its causative material is often phlegm, black bile or a combination of them. To treat warts, it is necessary to consider (...) groups (P < 0.001). Relapse was not seen in any groups after three months. The frequency of side effects was similar after three months.M. communis L. can be used as a topical treatment for warts. It not only shows more rapid response than salicylic acid, but also has fewer side effects. It seems that D. sophia L. can modify the digestion process and patients can excrete large amounts of the substance that causes warts. Therefore, it is better to use it more than 40 days. According to our

2014 Iranian Red Crescent medical journal Controlled trial quality: uncertain

164. Subcutaneous intralesional Ksharodaka injection: A novel treatment for the management of Warts: A case series Full Text available with Trip Pro

Subcutaneous intralesional Ksharodaka injection: A novel treatment for the management of Warts: A case series Warts are generally managed using cryosurgery, keratolytic ointments, curettage and electrodessication. Warts, vis-a-vis Charmakila, in Ayurvedic classical texts are classified into different types depending on the dominance of dosha. Ayurveda prescribes oral medications, topical use of Kshara (alkaline ash of herbs), Agni (thermal cautery) and Shastrakarma (surgery) for removal (...) of Charmakila. Use of topical Kshara in the form of powder, aqueous solution i.e. Ksharodaka and Ksharasutra (thread smeared with Kshara) for warts has been reported. However, these methods necessitate multiple sittings and takea longer duration for removal of the warts. Herewith, we report a case series of different types of warts treated with intralesional infiltration of Apamarga Ksharodaka (AK), i.e. aqueous solution of Apamarga (Achyranthes aspera) Kshara. We observed that all these warts took

2014 Journal of Ayurveda and integrative medicine

165. Imiquimod in the treatment of cutaneous warts: an evidence-based review. (Abstract)

Imiquimod in the treatment of cutaneous warts: an evidence-based review. Cutaneous warts are highly prevalent lesions caused by the infection of keratinocytes by different types of human papillomaviruses. Although cutaneous warts are capable of resolving spontaneously, these infections can persist for long periods of time by evading the host immune system, and, as a result, many patients choose to seek treatment. Imiquimod is an immune response modifier that is approved as a topical cream (...) for the treatment of anogenital warts by the US Food and Drug Administration. However, the efficacy of imiquimod in the treatment of cutaneous warts has not been well established.The purpose of this article is to systematically review the published literature regarding the efficacy of imiquimod in the treatment of cutaneous warts, and to evaluate the quality and outcomes of these studies.A literature search was performed through clinical queries PubMed (National Library of Medicine) database and the Cochrane

2014 American journal of clinical dermatology

166. Comparison of efficacy of 5% potassium hydroxide solution versus cryotherapy in the treatment of male genital wart: a randomized clinical trial. (Abstract)

Comparison of efficacy of 5% potassium hydroxide solution versus cryotherapy in the treatment of male genital wart: a randomized clinical trial. 24566576 2014 06 02 2014 09 26 0392-0488 149 1 2014 Feb Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia G Ital Dermatol Venereol Comparison of efficacy of 5% potassium hydroxide solution versus cryotherapy in the treatment of male genital wart: a randomized clinical trial. 149-50

2014 Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia Controlled trial quality: uncertain

167. Needling versus liquid nitrogen cryotherapy for the treatment of pedal warts: A randomised controlled trial pilot study. (Abstract)

Needling versus liquid nitrogen cryotherapy for the treatment of pedal warts: A randomised controlled trial pilot study. Abstract Background: The hypothesis of this study was that needling of a pedal wart would create local inflammation and a subsequent cell-mediated immune response against human papillomavirus. The primary objective of this study was to investigate if needling to induce a cell-mediated immune response against human papillomavirus is an effective treatment of pedal warts (...) in comparison to liquid nitrogen cryotherapy. A secondary objective of this study was to investigate if the cell-mediated immune response induced by needling is effective against satellite pedal warts. Methods: Eligible participants presenting to the University of Western Australia Podiatry Clinic with pedal wart/s were randomly allocated to treatment - either needling or liquid nitrogen cryotherapy. Only the primary pedal wart was treated during the study. Participant follow-up was twelve weeks

2014 Journal of the American Podiatric Medical Association Controlled trial quality: uncertain

168. Needling Versus Liquid Nitrogen Cryotherapy for the Treatment of Pedal Warts A Randomized Controlled Pilot Study. (Abstract)

Needling Versus Liquid Nitrogen Cryotherapy for the Treatment of Pedal Warts A Randomized Controlled Pilot Study. We hypothesized that needling of a pedal wart creates local inflammation and a subsequent cell-mediated immune response (CMIR) against human papillomavirus. The primary objective of this study was to investigate whether needling to induce a CMIR against human papillomavirus is an effective treatment for pedal warts compared with liquid nitrogen cryotherapy. A secondary objective (...) was to investigate whether the CMIR induced by needling is effective against satellite pedal warts.Eligible patients with pedal warts were randomly allocated to receive either needling or liquid nitrogen cryotherapy. Only the primary pedal wart was treated during the study. Follow-up was 12 weeks, with outcome assessments made independently under blinded circumstances.Of 37 patients enrolled in the study, 18 were allocated to receive needling and 19 to receive liquid nitrogen cryotherapy. Regression

2014 Journal of the American Podiatric Medical Association Controlled trial quality: uncertain

169. Treatment of recalcitrant warts with intralesional measles, mumps, and rubella vaccine: a promising approach. (Abstract)

Treatment of recalcitrant warts with intralesional measles, mumps, and rubella vaccine: a promising approach. Recalcitrant warts represent a frustrating challenge for both patients and physicians. Although many destructive and immunotherapeutic modalities are available for the treatment of warts, an ideal, universally effective approach has not been explored to date. Recently, intralesional antigen immunotherapy has shown promising efficacy in the treatment of warts. The aim of the study (...) was to evaluate the efficacy and safety of intralesional measles, mumps, and rubella (MMR) vaccine in the treatment of recalcitrant warts.The study included 70 adult patients with multiple recalcitrant extragenital warts of different sizes and durations, with or without distant warts. They were directly injected, without a pre-sensitization skin test, with 0.3 intralesional MMR vaccine into the largest wart at 2-week intervals until complete clearance or for a maximum of five treatments. Follow-up was made

2014 International Journal of Dermatology

170. Efficacy of combination therapy of oral zinc sulfate with imiquimod, podophyllin or cryotherapy in the treatment of vulvar warts. (Abstract)

Efficacy of combination therapy of oral zinc sulfate with imiquimod, podophyllin or cryotherapy in the treatment of vulvar warts. Zinc sulfate is beneficial in the treatment of epithelial warts. We conducted this study to compare the efficacy of combination therapy of oral zinc sulfate with conventional treatments in the treatment of vulvar warts.This study was a randomized controlled trial. The sample size was 42 in each group. Women aged 20-50 years were placed by the block randomized method (...) in the podophyllin-, imiquimod- and cryotherapy-treated patients compared to patients receiving these treatments in combination with oral zinc sulfate (P<0.05).Combined therapy of oral zinc sulfate with conventional treatments of vulvar warts appears to reduce the relapse rate.© 2014 The Authors. Journal of Obstetrics and Gynaecology Research © 2014 Japan Society of Obstetrics and Gynecology.

2014 The journal of obstetrics and gynaecology research Controlled trial quality: uncertain

171. Treatment of External Genital Warts With Cryotherapy and Sinecatechins 15% Ointment

Treatment of External Genital Warts With Cryotherapy and Sinecatechins 15% Ointment Treatment of External Genital Warts With Cryotherapy and Sinecatechins 15% Ointment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Treatment of External Genital Warts With Cryotherapy and Sinecatechins 15% Ointment The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02147353 Recruitment Status : Completed First Posted : May 26, 2014 Last Update Posted : July 10, 2015 Sponsor: Icahn School of Medicine at Mount Sinai

2014 Clinical Trials

172. Pyruvic Acid Versus Salicylic Acid Preparation in Treatment of Plantar Warts

Pyruvic Acid Versus Salicylic Acid Preparation in Treatment of Plantar Warts Pyruvic Acid Versus Salicylic Acid Preparation in Treatment of Plantar Warts - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Pyruvic Acid Versus Salicylic Acid Preparation in Treatment of Plantar Warts The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02151630 Recruitment Status : Unknown Verified May 2014 by Fatima Assaf, Isfahan University of Medical Sciences. Recruitment status was: Recruiting First Posted : May 30, 2014

2014 Clinical Trials

173. A double-blind, randomized, placebo-controlled trial of oral isotretinoin in the treatment of recalcitrant facial flat warts. (Abstract)

A double-blind, randomized, placebo-controlled trial of oral isotretinoin in the treatment of recalcitrant facial flat warts. Abstract Background: Recalcitrant facial flat warts are caused by human papillomavirus and may persist for years despite treatment. Isotretinoin has demonstrated benefits in the treatment of recalcitrant, genital and common warts, but placebo-controlled trials have not been performed.To determine whether isotretinoin is safe and effective for recalcitrant facial flat (...) of the study is a lack of follow-up to assess for recurrence after the drug was discontinued.Isotretinoin is an effective treatment for recalcitrant flat facial warts with a well-known, manageable safety profile.

2014 Journal of Dermatological Treatment Controlled trial quality: predicted high

174. Investigations of the efficacy of diphenylcyclopropenone immunotherapy for the treatment of warts. (Abstract)

Investigations of the efficacy of diphenylcyclopropenone immunotherapy for the treatment of warts. Diphenylcyclopropenone (DPCP) immunotherapy has been used to treat warts, particularly in patients, such as children, who cannot endure treatment-related pain and in patients with large numbers of warts. However, the efficacy of DPCP immunotherapy remains subject to much controversy. Specifically, cure rates and treatment durations have varied across reports, primarily because of the lack of large (...) -scale studies.We performed an uncontrolled, open-label study to investigate the efficacy of DPCP immunotherapy for the treatment of cutaneous warts. A total of 170 patients with warts were enrolled in this uncontrolled, open-label study from 2006 to 2012. Each patient was sensitized with 0.1% DPCP. Two weeks after sensitization, DPCP was applied to warts once per week.We achieved high clearance rates in 141 of 170 patients (82.9%) and 434 of 511 lesions (84.9%). Immunotherapy with DPCP was much more

2014 International Journal of Dermatology

175. A comparison of a 5% potassium hydroxide solution with a 5-fluorouracil and salicylic acid combination in the treatment of patients with anogenital warts: a randomized, open-label clinical trial. (Abstract)

A comparison of a 5% potassium hydroxide solution with a 5-fluorouracil and salicylic acid combination in the treatment of patients with anogenital warts: a randomized, open-label clinical trial. Anogenital warts are caused by human papillomavirus (HPV), over 30 types of which are infectious for the anogenital tract. Without treatment, warts may regress spontaneously, remain unchanged, or increase in number and size. This study compared the efficacy of a topical 5% potassium hydroxide (KOH (...) ) solution with that of a topical 0.5% 5-fluorouracil (5-FU) and 10% salicylic acid (SA) combination in the treatment of anogenital warts. Sixty patients were randomly assigned to receive topical KOH or 5-FU + SA. Both groups demonstrated a significant decrease in numbers of lesions (P < 0.05), but this difference was not significant at week 12 (P > 0.05). The mean number of lesions decreased from baseline to week 12 from 17.03 ± 12.64 to 3.73 ± 7.30 and from 16.13 ± 12.97 to 3.10 ± 4.90 in the KOH and 5

2014 International journal of dermatology Controlled trial quality: uncertain

176. Pulsed dye laser treatment for recalcitrant viral warts: a retrospective case series of 227 patients. (Abstract)

Pulsed dye laser treatment for recalcitrant viral warts: a retrospective case series of 227 patients. 24813813 2015 07 14 2014 11 21 1365-2133 171 5 2014 Nov The British journal of dermatology Br. J. Dermatol. Pulsed-dye laser treatment for recalcitrant viral warts: a retrospective case series of 227 patients. 1270-3 10.1111/bjd.13099 Sparreboom E E EE Department of Dermatology, Máxima Medical Centre Veldhoven, De Run 4600, P.O. Box 7777, 5500 MB, Veldhoven, the Netherlands. Luijks H G HG (...) Luiting-Welkenhuyzen H A L HA Willems P W J M PW Groeneveld C P M CP Bovenschen H J HJ eng Letter 2014 09 26 England Br J Dermatol 0004041 0007-0963 IM Adolescent Adult Aged Child Child, Preschool Cicatrix etiology Female Humans Infant Infant, Newborn Lasers, Dye therapeutic use Male Middle Aged Prospective Studies Retrospective Studies Treatment Outcome Warts surgery Young Adult 2014 5 13 6 0 2014 5 13 6 0 2015 7 15 6 0 ppublish 24813813 10.1111/bjd.13099

2014 British Journal of Dermatology

177. A randomized trial of efficacy of beta-sitosterol and its glucoside as adjuvant to cryotherapy in the treatment of anogenital warts. Full Text available with Trip Pro

A randomized trial of efficacy of beta-sitosterol and its glucoside as adjuvant to cryotherapy in the treatment of anogenital warts. All available treatments for anogenital warts have substantial failure rates. An immunomodulating treatment that enhances the patient's own immunity could be valuable as an adjuvant to conventional methods.About 123 patients were enrolled in this study and were randomized either to undergo only cryotherapy every 3 weeks (n = 60 patients) or to undergo cryotherapy (...) and to receive a mixture containing 20 mg sterol and 0.2 mg sterolin (BSS-BSSG mixture), known for its immunomodulating properties (n = 63).A complete response after 3 months was demonstrated by 18.3% of the patients in the first group and 30.2% of the second group, while 61.7% of the first group and 79.4% of the second group were lesion free at the end of the 6-month follow-up period. Cox regression analysis of the time until response showed a significant advantage to the mixture treatment group (hazard

2014 Journal of Dermatological Treatment Controlled trial quality: uncertain

178. A prospective, open, comparative study of 5% potassium hydroxide solution versus cryotherapy in the treatment of genital warts in men. Full Text available with Trip Pro

A prospective, open, comparative study of 5% potassium hydroxide solution versus cryotherapy in the treatment of genital warts in men. Genital warts are caused by human papillomavirus infection and represent one of the most common sexually transmitted diseases. Many infections are transient but the virus may recur, persist, or become latent. To date, there is no effective antiviral treatment to eliminate HPV infection and most therapies are aimed at the destruction of visible lesions. Potassium (...) hydroxide is a strong alkali that has been shown to be safe and effective for the treatment of genital warts and molluscum contagiosum. Cryotherapy is considered one of the most established treatments for genital warts. No comparative trials have been reported to date on the use of potassium hydroxide for genital warts.A prospective, open-label, randomized clinical trial was conducted to compare topical potassium hydroxide versus cryotherapy in the treatment of genital warts affecting immunocompetent

2014 Anais brasileiros de dermatologia Controlled trial quality: uncertain

179. Childhood skin and soft tissue infections: new discoveries and guidelines regarding the management of bacterial soft tissue infections, molluscum contagiosum, and warts. (Abstract)

Childhood skin and soft tissue infections: new discoveries and guidelines regarding the management of bacterial soft tissue infections, molluscum contagiosum, and warts. Pediatric skin and soft tissue infections (SSTIs) constitute a significant number of office-based pediatric visits. With SSTIs on the rise, it is not only important to effectively treat the individual, but to do so appropriately and cost-consciously. In this article, we highlight new research related to the treatment (...) of bacterial skin infections, molluscum contagiosum, and cutaneous warts, with the goal of guiding pediatricians in their practice against these common skin conditions.Recent data supports the use of topical antibiotics for noncomplicated impetigo. Systemic antibiotics covering gram-positive cocci are recommended for complicated cases of impetigo and deeper nonpurulent SSTIs. Localized purulent bacterial SSTIs can be treated with incision and drainage alone but more systemic involvement warrants treatment

2016 Current Opinion in Pediatrics

180. Low- and high-risk human papillomavirus genotype infections in intra-anal warts in HIV-positive men-who-have-sex-with-men. Full Text available with Trip Pro

Low- and high-risk human papillomavirus genotype infections in intra-anal warts in HIV-positive men-who-have-sex-with-men. Anogenital warts are often presumed to represent nondysplastic or low-grade anal intraepithelial neoplasia (LGAIN). We previously demonstrated that up to 20% of intra-anal warts in HIV-positive men who have sex with men (MSM) contain regions of high-grade AIN (HGAIN).To determine the causative human papillomavirus (HPV) types of low- and high- grade dysplastic areas (...) in warts from HIV-positive MSM.A total of 42 intra-anal warts from 41 HIV-positive MSM were graded as nondysplastic, LGAIN or HGAIN. Whole-tissue sections (WTS) were analysed with the SPF10 polymerase chain reaction/LiPA25 HPV genotyping system. If the WTS contained multiple HPV types, dysplastic regions were isolated by laser capture microdissection (LCM) for HPV genotyping.Overall, 38 of 42 (91%) WTS tested positive for HPV DNA. Of these, 23 (61%) contained a single HPV type and 15 (39%) contained

2016 British Journal of Dermatology

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