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Wart Treatment

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161. Needling versus liquid nitrogen cryotherapy for the treatment of pedal warts: A randomised controlled trial pilot study. (Abstract)

Needling versus liquid nitrogen cryotherapy for the treatment of pedal warts: A randomised controlled trial pilot study. Abstract Background: The hypothesis of this study was that needling of a pedal wart would create local inflammation and a subsequent cell-mediated immune response against human papillomavirus. The primary objective of this study was to investigate if needling to induce a cell-mediated immune response against human papillomavirus is an effective treatment of pedal warts (...) in comparison to liquid nitrogen cryotherapy. A secondary objective of this study was to investigate if the cell-mediated immune response induced by needling is effective against satellite pedal warts. Methods: Eligible participants presenting to the University of Western Australia Podiatry Clinic with pedal wart/s were randomly allocated to treatment - either needling or liquid nitrogen cryotherapy. Only the primary pedal wart was treated during the study. Participant follow-up was twelve weeks

2014 Journal of the American Podiatric Medical Association Controlled trial quality: uncertain

162. Needling Versus Liquid Nitrogen Cryotherapy for the Treatment of Pedal Warts A Randomized Controlled Pilot Study. (Abstract)

Needling Versus Liquid Nitrogen Cryotherapy for the Treatment of Pedal Warts A Randomized Controlled Pilot Study. We hypothesized that needling of a pedal wart creates local inflammation and a subsequent cell-mediated immune response (CMIR) against human papillomavirus. The primary objective of this study was to investigate whether needling to induce a CMIR against human papillomavirus is an effective treatment for pedal warts compared with liquid nitrogen cryotherapy. A secondary objective (...) was to investigate whether the CMIR induced by needling is effective against satellite pedal warts.Eligible patients with pedal warts were randomly allocated to receive either needling or liquid nitrogen cryotherapy. Only the primary pedal wart was treated during the study. Follow-up was 12 weeks, with outcome assessments made independently under blinded circumstances.Of 37 patients enrolled in the study, 18 were allocated to receive needling and 19 to receive liquid nitrogen cryotherapy. Regression

2014 Journal of the American Podiatric Medical Association Controlled trial quality: uncertain

163. Treatment of recalcitrant warts with intralesional measles, mumps, and rubella vaccine: a promising approach. (Abstract)

Treatment of recalcitrant warts with intralesional measles, mumps, and rubella vaccine: a promising approach. Recalcitrant warts represent a frustrating challenge for both patients and physicians. Although many destructive and immunotherapeutic modalities are available for the treatment of warts, an ideal, universally effective approach has not been explored to date. Recently, intralesional antigen immunotherapy has shown promising efficacy in the treatment of warts. The aim of the study (...) was to evaluate the efficacy and safety of intralesional measles, mumps, and rubella (MMR) vaccine in the treatment of recalcitrant warts.The study included 70 adult patients with multiple recalcitrant extragenital warts of different sizes and durations, with or without distant warts. They were directly injected, without a pre-sensitization skin test, with 0.3 intralesional MMR vaccine into the largest wart at 2-week intervals until complete clearance or for a maximum of five treatments. Follow-up was made

2014 International Journal of Dermatology

164. Efficacy of combination therapy of oral zinc sulfate with imiquimod, podophyllin or cryotherapy in the treatment of vulvar warts. (Abstract)

Efficacy of combination therapy of oral zinc sulfate with imiquimod, podophyllin or cryotherapy in the treatment of vulvar warts. Zinc sulfate is beneficial in the treatment of epithelial warts. We conducted this study to compare the efficacy of combination therapy of oral zinc sulfate with conventional treatments in the treatment of vulvar warts.This study was a randomized controlled trial. The sample size was 42 in each group. Women aged 20-50 years were placed by the block randomized method (...) in the podophyllin-, imiquimod- and cryotherapy-treated patients compared to patients receiving these treatments in combination with oral zinc sulfate (P<0.05).Combined therapy of oral zinc sulfate with conventional treatments of vulvar warts appears to reduce the relapse rate.© 2014 The Authors. Journal of Obstetrics and Gynaecology Research © 2014 Japan Society of Obstetrics and Gynecology.

2014 The journal of obstetrics and gynaecology research Controlled trial quality: uncertain

165. Treatment of External Genital Warts With Cryotherapy and Sinecatechins 15% Ointment

Treatment of External Genital Warts With Cryotherapy and Sinecatechins 15% Ointment Treatment of External Genital Warts With Cryotherapy and Sinecatechins 15% Ointment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Treatment of External Genital Warts With Cryotherapy and Sinecatechins 15% Ointment The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02147353 Recruitment Status : Completed First Posted : May 26, 2014 Last Update Posted : July 10, 2015 Sponsor: Icahn School of Medicine at Mount Sinai

2014 Clinical Trials

166. Pyruvic Acid Versus Salicylic Acid Preparation in Treatment of Plantar Warts

Pyruvic Acid Versus Salicylic Acid Preparation in Treatment of Plantar Warts Pyruvic Acid Versus Salicylic Acid Preparation in Treatment of Plantar Warts - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Pyruvic Acid Versus Salicylic Acid Preparation in Treatment of Plantar Warts The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02151630 Recruitment Status : Unknown Verified May 2014 by Fatima Assaf, Isfahan University of Medical Sciences. Recruitment status was: Recruiting First Posted : May 30, 2014

2014 Clinical Trials

167. A double-blind, randomized, placebo-controlled trial of oral isotretinoin in the treatment of recalcitrant facial flat warts. (Abstract)

A double-blind, randomized, placebo-controlled trial of oral isotretinoin in the treatment of recalcitrant facial flat warts. Abstract Background: Recalcitrant facial flat warts are caused by human papillomavirus and may persist for years despite treatment. Isotretinoin has demonstrated benefits in the treatment of recalcitrant, genital and common warts, but placebo-controlled trials have not been performed.To determine whether isotretinoin is safe and effective for recalcitrant facial flat (...) of the study is a lack of follow-up to assess for recurrence after the drug was discontinued.Isotretinoin is an effective treatment for recalcitrant flat facial warts with a well-known, manageable safety profile.

2014 Journal of Dermatological Treatment Controlled trial quality: predicted high

168. Investigations of the efficacy of diphenylcyclopropenone immunotherapy for the treatment of warts. (Abstract)

Investigations of the efficacy of diphenylcyclopropenone immunotherapy for the treatment of warts. Diphenylcyclopropenone (DPCP) immunotherapy has been used to treat warts, particularly in patients, such as children, who cannot endure treatment-related pain and in patients with large numbers of warts. However, the efficacy of DPCP immunotherapy remains subject to much controversy. Specifically, cure rates and treatment durations have varied across reports, primarily because of the lack of large (...) -scale studies.We performed an uncontrolled, open-label study to investigate the efficacy of DPCP immunotherapy for the treatment of cutaneous warts. A total of 170 patients with warts were enrolled in this uncontrolled, open-label study from 2006 to 2012. Each patient was sensitized with 0.1% DPCP. Two weeks after sensitization, DPCP was applied to warts once per week.We achieved high clearance rates in 141 of 170 patients (82.9%) and 434 of 511 lesions (84.9%). Immunotherapy with DPCP was much more

2014 International Journal of Dermatology

169. A comparison of a 5% potassium hydroxide solution with a 5-fluorouracil and salicylic acid combination in the treatment of patients with anogenital warts: a randomized, open-label clinical trial. (Abstract)

A comparison of a 5% potassium hydroxide solution with a 5-fluorouracil and salicylic acid combination in the treatment of patients with anogenital warts: a randomized, open-label clinical trial. Anogenital warts are caused by human papillomavirus (HPV), over 30 types of which are infectious for the anogenital tract. Without treatment, warts may regress spontaneously, remain unchanged, or increase in number and size. This study compared the efficacy of a topical 5% potassium hydroxide (KOH (...) ) solution with that of a topical 0.5% 5-fluorouracil (5-FU) and 10% salicylic acid (SA) combination in the treatment of anogenital warts. Sixty patients were randomly assigned to receive topical KOH or 5-FU + SA. Both groups demonstrated a significant decrease in numbers of lesions (P < 0.05), but this difference was not significant at week 12 (P > 0.05). The mean number of lesions decreased from baseline to week 12 from 17.03 ± 12.64 to 3.73 ± 7.30 and from 16.13 ± 12.97 to 3.10 ± 4.90 in the KOH and 5

2014 International journal of dermatology Controlled trial quality: uncertain

170. Pulsed dye laser treatment for recalcitrant viral warts: a retrospective case series of 227 patients. (Abstract)

Pulsed dye laser treatment for recalcitrant viral warts: a retrospective case series of 227 patients. 24813813 2015 07 14 2014 11 21 1365-2133 171 5 2014 Nov The British journal of dermatology Br. J. Dermatol. Pulsed-dye laser treatment for recalcitrant viral warts: a retrospective case series of 227 patients. 1270-3 10.1111/bjd.13099 Sparreboom E E EE Department of Dermatology, Máxima Medical Centre Veldhoven, De Run 4600, P.O. Box 7777, 5500 MB, Veldhoven, the Netherlands. Luijks H G HG (...) Luiting-Welkenhuyzen H A L HA Willems P W J M PW Groeneveld C P M CP Bovenschen H J HJ eng Letter 2014 09 26 England Br J Dermatol 0004041 0007-0963 IM Adolescent Adult Aged Child Child, Preschool Cicatrix etiology Female Humans Infant Infant, Newborn Lasers, Dye therapeutic use Male Middle Aged Prospective Studies Retrospective Studies Treatment Outcome Warts surgery Young Adult 2014 5 13 6 0 2014 5 13 6 0 2015 7 15 6 0 ppublish 24813813 10.1111/bjd.13099

2014 British Journal of Dermatology

171. A randomized trial of efficacy of beta-sitosterol and its glucoside as adjuvant to cryotherapy in the treatment of anogenital warts. Full Text available with Trip Pro

A randomized trial of efficacy of beta-sitosterol and its glucoside as adjuvant to cryotherapy in the treatment of anogenital warts. All available treatments for anogenital warts have substantial failure rates. An immunomodulating treatment that enhances the patient's own immunity could be valuable as an adjuvant to conventional methods.About 123 patients were enrolled in this study and were randomized either to undergo only cryotherapy every 3 weeks (n = 60 patients) or to undergo cryotherapy (...) and to receive a mixture containing 20 mg sterol and 0.2 mg sterolin (BSS-BSSG mixture), known for its immunomodulating properties (n = 63).A complete response after 3 months was demonstrated by 18.3% of the patients in the first group and 30.2% of the second group, while 61.7% of the first group and 79.4% of the second group were lesion free at the end of the 6-month follow-up period. Cox regression analysis of the time until response showed a significant advantage to the mixture treatment group (hazard

2014 Journal of Dermatological Treatment Controlled trial quality: uncertain

172. A prospective, open, comparative study of 5% potassium hydroxide solution versus cryotherapy in the treatment of genital warts in men. Full Text available with Trip Pro

A prospective, open, comparative study of 5% potassium hydroxide solution versus cryotherapy in the treatment of genital warts in men. Genital warts are caused by human papillomavirus infection and represent one of the most common sexually transmitted diseases. Many infections are transient but the virus may recur, persist, or become latent. To date, there is no effective antiviral treatment to eliminate HPV infection and most therapies are aimed at the destruction of visible lesions. Potassium (...) hydroxide is a strong alkali that has been shown to be safe and effective for the treatment of genital warts and molluscum contagiosum. Cryotherapy is considered one of the most established treatments for genital warts. No comparative trials have been reported to date on the use of potassium hydroxide for genital warts.A prospective, open-label, randomized clinical trial was conducted to compare topical potassium hydroxide versus cryotherapy in the treatment of genital warts affecting immunocompetent

2014 Anais brasileiros de dermatologia Controlled trial quality: uncertain

173. Childhood skin and soft tissue infections: new discoveries and guidelines regarding the management of bacterial soft tissue infections, molluscum contagiosum, and warts. (Abstract)

Childhood skin and soft tissue infections: new discoveries and guidelines regarding the management of bacterial soft tissue infections, molluscum contagiosum, and warts. Pediatric skin and soft tissue infections (SSTIs) constitute a significant number of office-based pediatric visits. With SSTIs on the rise, it is not only important to effectively treat the individual, but to do so appropriately and cost-consciously. In this article, we highlight new research related to the treatment (...) of bacterial skin infections, molluscum contagiosum, and cutaneous warts, with the goal of guiding pediatricians in their practice against these common skin conditions.Recent data supports the use of topical antibiotics for noncomplicated impetigo. Systemic antibiotics covering gram-positive cocci are recommended for complicated cases of impetigo and deeper nonpurulent SSTIs. Localized purulent bacterial SSTIs can be treated with incision and drainage alone but more systemic involvement warrants treatment

2016 Current Opinion in Pediatrics

174. Low- and high-risk human papillomavirus genotype infections in intra-anal warts in HIV-positive men-who-have-sex-with-men. Full Text available with Trip Pro

Low- and high-risk human papillomavirus genotype infections in intra-anal warts in HIV-positive men-who-have-sex-with-men. Anogenital warts are often presumed to represent nondysplastic or low-grade anal intraepithelial neoplasia (LGAIN). We previously demonstrated that up to 20% of intra-anal warts in HIV-positive men who have sex with men (MSM) contain regions of high-grade AIN (HGAIN).To determine the causative human papillomavirus (HPV) types of low- and high- grade dysplastic areas (...) in warts from HIV-positive MSM.A total of 42 intra-anal warts from 41 HIV-positive MSM were graded as nondysplastic, LGAIN or HGAIN. Whole-tissue sections (WTS) were analysed with the SPF10 polymerase chain reaction/LiPA25 HPV genotyping system. If the WTS contained multiple HPV types, dysplastic regions were isolated by laser capture microdissection (LCM) for HPV genotyping.Overall, 38 of 42 (91%) WTS tested positive for HPV DNA. Of these, 23 (61%) contained a single HPV type and 15 (39%) contained

2016 British Journal of Dermatology

175. Multiple Human Papillomavirus Infection Is Associated with High-Risk Infection in Male Genital Warts in Ulsan, Korea Full Text available with Trip Pro

clinics in Ulsan, Korea, for the treatment of genital warts between April 2014 and January 2015. All patients underwent HPV genotyping. The prevalence and characteristics of HPV infection were analyzed, and the patterns of HPV infection according to age were assessed. Among the study patients, 13 (16.3%) were negative for HPV infection, 46 (57.3%) were infected with low-risk HPV, and 21 (26.3%) were infected with high-risk HPV. Patients with multiple HPV infection were more likely to have high-risk (...) Multiple Human Papillomavirus Infection Is Associated with High-Risk Infection in Male Genital Warts in Ulsan, Korea Further understanding of male human papillomavirus (HPV) infection is necessary to prevent infection in men, as well as transmission to women. In our current study, we investigated patterns of HPV infection and genotype distributions in male genital warts using the Anyplex II HPV28 Detection kit. We reviewed the medical records of 80 male patients who presented to 5 neighborhood

2016 Journal of Korean medical science

176. Clinicoepidemiological Study of Different Types of Warts Full Text available with Trip Pro

(28%), and housewives (16%) were the usual occupations. Cosmetic concern (92%), pain (16%), and itching (15%) were the common complaints. All patients of genital warts sought treatment within 6 months. Conclusions. Common, palmoplantar, and plane warts were the common types of nongenital warts. Overall prevalence peaked during the second decade but one-third of the cases of plane warts occurred during the first. Extremities were the most common sites (66.7%); face was the next commonly (23 (...) Clinicoepidemiological Study of Different Types of Warts Background. Warts are cutaneous and, sometimes, mucosal lesions caused by one of the several human papilloma viruses. Aim. Assessment of the clinicoepidemiological aspects of warts. Materials and Methods. One hundred consecutive patients of warts presenting to the department of our institution were assigned two broad locational groups: genital and nongenital warts, the latter subdivided into common, plane, palmoplantar, mosaic

2016 Dermatology research and practice

177. A Study of A-101 Solution in Subjects With Common Warts.

Therapeutics, Inc. Study Details Study Description Go to Brief Summary: This is a randomized, double-blind, vehicle-controlled, parallel-group study with 3 treatment groups. Condition or disease Intervention/treatment Phase Common Warts Drug: A-101 Solution 40 Drug: A-101 Solution 45 Drug: Vehicle Solution Phase 2 Detailed Description: This is a randomized, double-blind, vehicle-controlled, parallel-group study with 3 treatment groups. During Visit 1, the Investigator will identify 1 eligible common wart (...) on the trunk or extremities on each subject. The wart will be treated up to a maximum of 8 times at 1 week intervals during the study. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 98 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double (Participant, Investigator) Primary Purpose: Treatment Official Title: A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of A-101 Solution

2016 Clinical Trials

178. A Phase 3 Study to Evaluate the Efficacy and Safety of CLS006 Versus Vehicle in Subjects 2 Years of Age or Older With Cutaneous Common Warts

vulgaris). Condition or disease Intervention/treatment Phase Cutaneous Common Warts Drug: CLS006 (Furosemide) Topical Gel Drug: Vehicle Topical Gel Phase 3 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 484 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Treatment Official Title: A Phase 3, Randomized (...) , Double-Blind, Vehicle-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of CLS006 Versus Vehicle in Subjects 2 Years of Age or Older With Cutaneous Common Warts Study Start Date : January 2017 Actual Primary Completion Date : April 16, 2018 Actual Study Completion Date : July 10, 2018 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: CLS006 (Furosemide) CLS006 (Furosemide

2016 Clinical Trials

179. Warts and verrucae

and neck). Plantar warts (verrucae) grow on the soles of the feet, often have dark dots in the centre, and may be painful. Mosaic warts occur when palmar or plantar warts coalesce into larger plaques on the hands and feet. Although warts can be cosmetically unsightly, they are not harmful, usually do not cause symptoms, and most resolve without treatment. Advice should be offered on reducing the risk of transmission and limiting personal spread of warts. Treatment should be considered if a wart (...) is painful, cosmetically unsightly, persistent, or the person requests treatment. For the treatment of other warts in adults and older children, options are topical salicylic acid, cryotherapy, or a combination of both (cryotherapy is not recommended for younger children). Warts can generally be managed in primary care, but referral to a dermatologist is necessary if the person has: An uncertain diagnosis. A facial wart. Multiple recalcitrant warts and compromised immunity. Extensive warts. Persistent

2014 NICE Clinical Knowledge Summaries

180. Exploratory Study of Efficacy and Safety of Ingenol Mebutate 0.05% Gel for Common Warts on the Hands.

Sponsor: Neal D. Bhatia, MD Collaborator: LEO Pharma Information provided by (Responsible Party): Neal D. Bhatia, MD, TCR Medical Corporation Study Details Study Description Go to Brief Summary: The purpose of this study is to determine if ingenol mebutate 0.05% gel is safe and effective in treating common warts on the hands. Condition or disease Intervention/treatment Phase Verruca Vulgaris Common Warts Drug: ingenol mebutate 0.05% gel Phase 1 Detailed Description: This is an open label exploratory (...) study evaluating the efficacy and safety of ingenol mebutate 0.05% gel for the treatment of verruca vulgaris. The study will be conducted at one site with one investigator, all subjects will receive active drug. Prior to the application of the investigational product (IP) on Day 1, the individual warts will be pared down with a 15 blade up to obtain debridement of intact skin to maximize exposure and allow for effective penetration of therapy into the lesion. Subjects can be screened for the study

2016 Clinical Trials

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