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Wart Treatment

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121. Cryotherapy to treat anogenital warts in nonimmunocompromised adults: Systematic review and meta-analysis. (PubMed)

Cryotherapy to treat anogenital warts in nonimmunocompromised adults: Systematic review and meta-analysis. Cryotherapy is one of the most commonly used therapeutic modalities to treat anogenital warts (AGWs), but this treatment was not clearly established in the recent international recommendations.To compare the efficacy and safety of cryotherapy versus other AGW treatments.Through a systematic search of 12 electronic databases, we identified 11 randomized controlled trials, screened from

2017 Journal of the American Academy of Dermatology

122. Anogenital warts and other HPV-associated anogenital lesions in the HIV-positive patient: a systematic review and meta-analysis of the efficacy and safety of interventions assessed in controlled clinical trials. (PubMed)

Anogenital warts and other HPV-associated anogenital lesions in the HIV-positive patient: a systematic review and meta-analysis of the efficacy and safety of interventions assessed in controlled clinical trials. Anogenital warts (AGW, condylomata acuminata) and intraepithelial neoplasia (IEN) do not only impact health and social well-being, they are also associated with considerable costs for the healthcare systems. Immunocompromised and HIV-positive patients carry the highest epidemiological (...) burden of human papillomavirus (HPV) infection and comprise a population specifically susceptible to treatment failures and recurrences. This systematic review aimed at identifying and appraising the available evidence from controlled studies of interventions for the treatment of AGW and IEN in immunocompromised patients.We conducted a comprehensive literature search. The Cochrane Collaboration's tool was used to assess risk of bias in included studies. Our confidence in the (pooled) effect-estimates

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2017 Sexually transmitted infections

123. A cross-sectional study estimating the burden of illness related to genital warts in South Korea. (PubMed)

A cross-sectional study estimating the burden of illness related to genital warts in South Korea. Estimate the prevalence of genital warts (GW) and GW-related healthcare resource use and costs among male and female patients seeking treatment in South Korea.To estimate GW prevalence, physicians in five major South Korean regions recorded daily logs of patients (n=71 655) seeking care between July 26 and September 27, 2011. Overall prevalence estimates (and 95% CIs) were weighted by the estimated (...) years' experience.The estimated overall GW prevalence was 0.7% (95% CI 0.7% to 0.8%). Among women, GW prevalence was 0.6% (95% CI 0.6% to 0.7%); among men prevalence was 1.0% (95% CI 0.9% to 1.0%), peaking among patients aged 18-24 years. Median costs for GW diagnosis and treatment for male patients were US$58.2 (South Korean Won (KRW) ₩66 857) and US$66.3 (KRW₩76 113) for female patients.The estimated overall GW prevalence in South Korea was 0.7% and was higher for male patients. The overall median

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2017 BMJ open

124. Significance of interferon gamma in the prediction of successful therapy of common warts by intralesional injection of Candida antigen. (PubMed)

Significance of interferon gamma in the prediction of successful therapy of common warts by intralesional injection of Candida antigen. Treatment of common warts remains a continuing challenge for both patients and physicians. Recently, intralesional immunotherapy by different antigens has proved efficacious in the treatment of warts, however, no definite predictive factors for successful therapy have been established. Herein, we evaluate the efficacy and safety of Candida antigen (...) in the treatment of common warts and the significance of interferon gamma (IFN-γ) in the prediction of successful therapy.The study included 54 patients with multiple common warts. A blood sample was collected from patients before therapy, cultured, and treated with Candida antigen for evaluation of IFN-γ. Candida antigen was directly injected into the largest wart at 2-week intervals until complete clearance or for a maximum of five treatments. Follow-up was made for 6 months to detect any recurrence.Complete

2017 International Journal of Dermatology

125. Heat-Induced Editing of HPV Genes to Clear Mucocutaneous Warts? (PubMed)

Heat-Induced Editing of HPV Genes to Clear Mucocutaneous Warts? Hyperthermia increases expression of the antiviral cellular factors APOBEC3A and APOBEC3G and induces G-to-A or C-to-T mutations in human papilloma virus cervical cell lines and genital warts. This unexpected effect of heat treatment correlated with regression of genital warts in a subset of patients, including at distant sites, suggesting that this effect may be mediated in part by antiviral as well as immunological

2017 Journal of Investigative Dermatology

126. Prevalence and incidence of external genital warts in a sample of Italian general female population. (PubMed)

the effectiveness of community clinical networks in investigating STI epidemiology among women from the general population, confirm the relevance of HPV vaccination programs among adolescents, and underscore the need of promoting safe sex, implementing early diagnosis, treatment and prevention of genital warts. (...) Prevalence and incidence of external genital warts in a sample of Italian general female population. The Human papillomavirus is the most common sexually transmitted virus worldwide. The objective of this study was to estimate: 1) the prevalence and the incidence of external genital warts (eGW) in a sample of women attending community outpatient clinics and 2) the total number of eGW cases in the Italian female population aged 15-64 years.A prospective study was performed for a 12-month period

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2017 BMC Infectious Diseases

127. A Phase2 of A-101 Topical Solution in Subjects With Common Warts

Details Study Description Go to Brief Summary: The primary objective of this study is to evaluate the effectiveness of A-101 compared to vehicle when applied to 1 common target wart on the trunk or extremities. Condition or disease Intervention/treatment Phase Common Wart Drug: A-101 Topical Solution Phase 2 Detailed Description: The primary objective of this study is to evaluate the effectiveness of A-101 compared to vehicle when applied to 1 common target wart on the trunk or extremities (...) Purpose: Treatment Official Title: A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of A-101 Topical Solution Applied Once a Week in Subjects With Common Warts Actual Study Start Date : June 29, 2017 Actual Primary Completion Date : March 15, 2018 Actual Study Completion Date : March 15, 2018 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Active A-101 Topical Solution Drug: A-101

2017 Clinical Trials

128. A Study of A-101 Topical Solution Administered Twice a Week in Subjects With Common Warts

Therapeutics, Inc. Information provided by (Responsible Party): Aclaris Therapeutics, Inc. Study Details Study Description Go to Brief Summary: The primary objective of this study is to evaluate the effectiveness of A-101 compared to Vehicle when applied to 1 Target common wart on the trunk or extremities twice a week. Condition or disease Intervention/treatment Phase Common Wart Drug: A-101 Topical Solution Drug: A-101 Vehicle Solution Phase 2 Detailed Description: The primary objective of this study (...) ) Actual Enrollment : 159 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double (Participant, Investigator) Primary Purpose: Treatment Official Title: A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of A-101 Topical Solution Applied Twice a Week in Subjects With Common Warts Actual Study Start Date : July 13, 2017 Actual Primary Completion Date : March 1, 2018 Actual Study Completion Date : March 1, 2018 Resource links provided by the National

2017 Clinical Trials

129. Efficacy of Quadrivalent HPV Vaccine to Prevent Relapses of Genital Warts After Initial Therapeutic Response

population), with a heavy toll on patients' quality of life: low self-esteem and severe impairment of sexual well-being are common consequences. Treatments are painful and take time to achieve cure because of low complete remission (20 to 60%) and high recurrence rates (10 to 40%, 30% on average). Finding new means to reduce these recurrence rates thus seems justified. Infection with Human Papillomavirus (HPV) is responsible for EGW,other warts and some epithelial cancers. Out of two currently available (...) scheduled on site at M0, M2 and M6, 3 phone contacts at M1, M3 and M7, 2 clinical follow up visits on site at M9 and M12 + 1 unscheduled visit on site in case of EGW relapse during the study Condition or disease Intervention/treatment Phase Genital Warts Biological: Vaccination with Gardasil Biological: Injection of Normal Saline Phase 3 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 300 participants Allocation: Randomized

2017 Clinical Trials

130. A Study to Evaluate the Safety and Efficacy of CLS006 Versus Vehicle in Subjects 2 Years of Age or Older With Cutaneous Common Warts

or disease Intervention/treatment Phase Cutaneous Common Warts Drug: CLS006 Drug: CLS006 Vehicle Phase 3 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 491 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Treatment Official Title: A Phase 3, Randomized, Double-Blind, Vehicle-Controlled, Multicenter Study (...) to Evaluate the Efficacy and Safety of CLS006 Versus Vehicle in Subjects 2 Years of Age or Older With Cutaneous Common Warts Actual Study Start Date : October 30, 2017 Actual Primary Completion Date : August 22, 2018 Actual Study Completion Date : November 7, 2018 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: CLS006 Furosemide Topical Gel, 0.125% Drug: CLS006 Furosemide Topical Gel Experimental: CLS006

2017 Clinical Trials

131. Comparison Between Tuberculin Vaccine and Cryotherapy in Genital Wart Patients

: May 17, 2017 See Sponsor: Assiut University Information provided by (Responsible Party): Mena Ramsis Haleem, Assiut University Study Details Study Description Go to Brief Summary: Cutaneous and genital warts are common dermatological conditions caused by Human Papilloma Virus. Although it is a benign condition it causes disfigurement, has tendency to collect, can be transmitted to others, this makes adequate and timely treatment important, while many warts are resolve spontaneously over several (...) years, most patients seek treatment because the warts are unsightly and often tender or painful. Condition or disease Intervention/treatment Phase Genital Wart Biological: tuberculin Device: cryotherapy Phase 3 Detailed Description: Genital warts are highly contagious sexually transmitted diseases (STD) caused by infection of Human Papilloma Virus and, as the most common STD in developed countries, can currently be considered to be globally epidemic. It is estimated that the frequency of Human

2017 Clinical Trials

132. Efficacy of Punch Reduction Prior to Cryotherapy in Patients with Viral Warts: A Case-Control Study in a Single Tertiary Center (PubMed)

matched with cryotherapy-only controls in terms of size and location of the wart. We compared the number and cost of treatments between the two groups.Eleven of the total 39 patients were treated with cryotherapy in addition to punch biopsy and the average number of treatments was 4.1±3.3 (mean±standard deviation). In a case-control study, the ratio value of cost was 2.9±3.6 in the experimental group and was 5.9±4.1 in controls (p<0.05).Punch biopsies can decrease the number and cost of treatment (...) Efficacy of Punch Reduction Prior to Cryotherapy in Patients with Viral Warts: A Case-Control Study in a Single Tertiary Center Cutaneous warts are a common complaint to visit dermatologic clinic and its course is variable, ranging from spontaneous resolution to a chronic condition refractory to treatment.To evaluate the efficacy and safety of punch biopsy for cutaneous warts.Thirty-nine patients who received punch biopsy for warts were reviewed through charts and photos. Among them, 15 were

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2017 Annals of dermatology

133. Efficacy and Tolerability of Polyphenon E in “Difficult-to-Treat” Multiple Genital Warts in an HIV-Positive Male Subject (PubMed)

Efficacy and Tolerability of Polyphenon E in “Difficult-to-Treat” Multiple Genital Warts in an HIV-Positive Male Subject A 55-year-old man, nonsmoker, with a HIV-positive history came to our attention in February 2017. He was on treatment with StribildTM, 1 capsule daily (150 mg elvitegravir, 150 mg cobicistat, 200 mg emtricitabine, and 245 mg tenofovir disoproxil). The CD4+/CD8+ cellular count was 326/µL (normal values: 404-1,612); the CD3+/CD8+ cellular count was 819/µL (normal values (...) : 220-1,219). The CD4/CD8 ratio was 0.40 (normal value: >1). Several typical genital wart lesions were present at the penis shaft and at the level of the neck and the corona of glans. These lesions were present for 2 years. Several cryotherapy sessions (a total of 10 procedures) had been performed with partial success. At the initial visit a total of 5 lesions were present. Treatment with topical Polyphenon E 10% 3 times a day was prescribed and started. After 1 month of treatment the lesions were

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2017 Case reports in dermatology

134. Primary Care Corner with Geoffrey Modest MD: Cimetidine for Warts?

exists in the literature, there was another open-label study of 47 patients with multiple, nongenital warts treated with oral cimetidine for 3 months (at 30-40 mg/kg and a higher dose of 800mg tid for adults) finding improvement in 87% of children and 68% of adults, and complete clearance in 56% of kids and 44% of adults. followup data showed no recurrences in the 65% of patients they could reach who had complete clearance by the end of the study, though warts recurred if treatment stopped before all (...) Primary Care Corner with Geoffrey Modest MD: Cimetidine for Warts? Primary Care Corner with Geoffrey Modest MD: Cimetidine for Warts? | BMJ EBM Spotlight by By Dr. Geoffrey Modest I was going through piles of old medical articles, intent on throwing them out in this electronic age, but then found one from 2005 looking at the use of Geffrey Modest I have had several very impressive cases where using cimetidine, an H2-blocker but also used in the past as an immunoenhancer for some chemotherapy

2016 Evidence-Based Medicine blog

135. Efficacy of topical administration of Radix Euphorbiae Ebracteolatae on multiple plantar warts: A parallel randomized trial. (PubMed)

Efficacy of topical administration of Radix Euphorbiae Ebracteolatae on multiple plantar warts: A parallel randomized trial. To investigate the clinical efficacy of Radix Euphorbiae Ebracteolatae in treating multiple plantar warts.Twenty-eight patients with multiple plantar warts on both left and right feet were recruited. Warts on the left feet (treatment group) of all patients were externally treated with moderate ethanol extract of Radix Euphorbiae Ebracteolatae which was made of 30 g Radix (...) Euphorbiae Ebracteolatae putting into 100 mL of medical ethanol (75%). For the control group, moderate dose of 0.1% vitamin A acid ointment was externally applied onto the right-foot warts. The topical application of each treatment was conducted 3 times a day for both groups. After 4 and 8 weeks, the efficacy and side effects including skin erythema and blister were evaluated and observed.Compared with the pre-treatment, warts size of the control group was reduced after 8-week treatment (P<0.05). After 4

2017 Chinese journal of integrative medicine Controlled trial quality: uncertain

136. Daylight photodynamic therapy with methylene blue in plane warts: a randomized double-blind placebo controlled study. (PubMed)

Daylight photodynamic therapy with methylene blue in plane warts: a randomized double-blind placebo controlled study. Conventional photodynamic therapy is associated with inconveniently long clinic visits and discomfort during therapy. Daylight-photodynamic therapy (DL-PDT) is an effective treatment, nearly pain free and more convenient for both the clinics and patients. There are no published studies of methylene blue (MB) as a photosensitizer (PS) used in DL-PDT.Forty patients had multiple (...) plane warts; 20 patients were subjected to DL-PDT with topical 10% methylene blue gel, and 20 patients were subjected to DL-PDT with hematoxylin (placebo). Improvement was evaluated by change of the number of warts and the dermoscope picture.A total of 20 (100%) patients in group II showed no response to placebo, 13 patients (65%) in group I showed complete clearance, 2 (10%) patients showed a good response, and 5 (25%) patients had poor response to treatment (P < 0.01). No serious side effects

2017 Photodermatology, photoimmunology & photomedicine Controlled trial quality: uncertain

137. External genital and perianal warts: green tea (Camellia sinensis) leaf extract 10% ointment

summaries of product characteristics (SPCs), British national formulary (BNF) or the MHRA or NICE websites for up-to-date information. Summary Green tea (Camellia sinensis) leaf extract 10% ointment (Catephen) is a self-administered topical treatment for external genital and perianal warts. In 2 randomised controlled trials (RCTs) involving a total of 1005 adults, green tea leaf extract 10% ointment was 2-fold more effective than vehicle (placebo) ointment in terms of complete clearance of all baseline (...) and new warts over a maximum treatment duration of 16 weeks. Most reported adverse events were local skin reactions, and were mild or moderate in severity. There are no published comparisons with other active treatments for genital and perianal warts. Regulatory status Regulatory status: Catephen 10% ointment was launched in the UK in November 2015. © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 1 of 20Effectiv

2015 National Institute for Health and Clinical Excellence - Advice

138. Pharmacodynamics, Safety and Efficacy of Topical Omiganan in Patients With External Genital Warts

: Cutanea Life Sciences, Inc. Collaborator: Leiden University Medical Center Information provided by (Responsible Party): Cutanea Life Sciences, Inc. Study Details Study Description Go to Brief Summary: The purpose of this study is to assess the pharmacodynamics, safety and efficacy of omiganan in patients with external genital warts. Condition or disease Intervention/treatment Phase Condylomata Acuminata (External) Drug: Omiganan (CLS001) topical gel Drug: Vehicle topical gel Phase 2 Study Design Go (...) to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 24 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Treatment Official Title: A Phase 2, Randomized, Vehicle-Controlled, Double-Blind, Parallel-Group Study to Explore the Pharmacodynamics, Safety and Efficacy of Topical Omiganan in Patients With External Genital Warts Study Start

2016 Clinical Trials

139. A Phase 3 Study to Evaluate the Efficacy and Safety of CLS006 Versus Vehicle in Subjects 2 Years of Age or Older With Cutaneous Common Warts

vulgaris). Condition or disease Intervention/treatment Phase Cutaneous Common Warts Drug: CLS006 (Furosemide) Topical Gel Drug: Vehicle Topical Gel Phase 3 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 484 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Treatment Official Title: A Phase 3, Randomized (...) , Double-Blind, Vehicle-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of CLS006 Versus Vehicle in Subjects 2 Years of Age or Older With Cutaneous Common Warts Study Start Date : January 2017 Actual Primary Completion Date : April 16, 2018 Actual Study Completion Date : July 10, 2018 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: CLS006 (Furosemide) CLS006 (Furosemide

2016 Clinical Trials

140. A Study of A-101 Solution in Subjects With Common Warts.

Therapeutics, Inc. Study Details Study Description Go to Brief Summary: This is a randomized, double-blind, vehicle-controlled, parallel-group study with 3 treatment groups. Condition or disease Intervention/treatment Phase Common Warts Drug: A-101 Solution 40 Drug: A-101 Solution 45 Drug: Vehicle Solution Phase 2 Detailed Description: This is a randomized, double-blind, vehicle-controlled, parallel-group study with 3 treatment groups. During Visit 1, the Investigator will identify 1 eligible common wart (...) on the trunk or extremities on each subject. The wart will be treated up to a maximum of 8 times at 1 week intervals during the study. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 98 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double (Participant, Investigator) Primary Purpose: Treatment Official Title: A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of A-101 Solution

2016 Clinical Trials

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