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101. A Comparative Study of Potassium Hydroxide versus CO2 Laser Vaporization in The Treatment of Female Genital Warts: A Controlled Clinical Trial. (PubMed)

A Comparative Study of Potassium Hydroxide versus CO2 Laser Vaporization in The Treatment of Female Genital Warts: A Controlled Clinical Trial. Genital warts are the most common viral sexually transmitted disease affecting 1% of the population. A prospective, open-label controlled trial was performed to compare topical 5% potassium hydroxide (KOH) solution with CO2 laser in the treatment of female genital warts.Seventy patients were enrolled in the study after convenience sampling. Right-sided (...) as CO2 laser in the treatment of female genital warts. There was not any serious complication in the application of KOH solution. This could be used as a new treatment for genital warts.IRCT201412207848N1.

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2016 International journal of community based nursing and midwifery Controlled trial quality: uncertain

102. Comparative Evaluation of Topical 10% Potassium Hydroxide and 30% Trichloroacetic Acid in the Treatment of Plane Warts. (PubMed)

Comparative Evaluation of Topical 10% Potassium Hydroxide and 30% Trichloroacetic Acid in the Treatment of Plane Warts. Warts are benign proliferations of skin and mucosa caused by the human papillomavirus (HPV). Plane warts are caused by HPV types 3, 10, 28, and 41, occurring mostly in children and young adults. Among the treatment modalities, topical application of trichloroacetic acid (TCA) is age old. Potassium hydroxide (KOH) has a keratolytic effect on virus-infected cells. It is less (...) irritating, less painful, less scar forming, and can be safely used in children too. Hence, it could be a better topical agent in the treatment of plane warts.To compare the safety and efficacy of topical 10% KOH with 30% TCA in the treatment of plane warts.Sixty consecutive patients with plane warts were randomly assigned into two arms of thirty patients each; arm A received topical 10% KOH and arm B received topical 30% TCA as a once weekly application until the complete clearance of warts or a maximum

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2016 Indian journal of dermatology Controlled trial quality: uncertain

103. Promising New Wart Treatment: A Randomized, Placebo-Controlled, Clinical Trial. (PubMed)

Promising New Wart Treatment: A Randomized, Placebo-Controlled, Clinical Trial. Warts are common dermatological lesion caused by skin epithelial cells' infection with human Papillomavirus (HPV).This study aimed to assess the efficacy of a new method for the treatment of dermal warts.In this clinical trial study, 60 patients (older than 10 years) with dermal warts living in Baneh city, west of Iran, were allocated into the intervention and control groups using the block randomized method in 2012 (...) the intervention was statistically significant for both intervention (P = 0.009) and control groups (P = 0.0001).This method is recommended for the treatment of dermal warts, owing to the effectiveness, short duration of treatment, and low cost of topical treatment for dermal warts using HD tablets.

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2016 Iranian Red Crescent medical journal Controlled trial quality: uncertain

104. The Clinical Effectiveness of Intralesional Injection of 2% Zinc Sulfate Solution in the Treatment of Common Warts. (PubMed)

The Clinical Effectiveness of Intralesional Injection of 2% Zinc Sulfate Solution in the Treatment of Common Warts. Objective. To investigate the clinical efficacy and safety of intralesional injection of 2% zinc sulfate solution in the treatment of common warts. Patients and Methods. One hundred and twenty patients (78 females and 42 males) aged 5-55 years with 225 common warts participated in this prospective monocentric randomized study. All lesions were treated with intralesional injection (...) postinflammatory hyperpigmentation in 90 patients (75%), scaring in 9 patients (7.5%), and ulceration in 3 patients (2.5%). Recurrence occurred in 3 lesions (1.33%). Conclusion. The clinical data indicate that intralesional injection of 2% zinc sulfate is an effective maneuver in the treatment of common warts; however, its associated complications limit its use.

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2016 Scientifica Controlled trial quality: uncertain

105. Cryotherapy systems for wart removal: a review of the clinical effectiveness, cost-effectiveness, and guidelines

for Drugs and Technologies in Health (CADTH). Rapid Response. 2014 Authors' conclusions Limited evidence suggested that cryotherapy with liquid nitrogen using a melamine foam sponge (MFS) applicator was superior to cotton wool bud (CWB) applicators for reducing wart size after one treatment, with a lower mean number of treatments at complete remission and fewer adverse events, though the generalizability of these findings to a Canadian context is unclear. There was no evidence identified for the cost (...) -effectiveness comparing different cryotherapy systems. Guidelines suggest first line treatment using cryotherapy with liquid nitrogen every two to three weeks, up to three months for the removal of cutaneous warts. Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Cryotherapy; Humans; Warts Language Published English Country of organisation Canada Province or state Ontario English summary An English language summary is available. Address for correspondence Canadian Agency for Drugs

2014 Health Technology Assessment (HTA) Database.

106. Warts - anogenital

(for example HIV). Referral is essential if: The diagnosis is uncertain. Malignancy or intraepithelial neoplasia is suspected. The warts are cervical, intrameatal, or intra-anal. Treatment for anogenital warts should only be offered in primary care if: Referral to a sexual health specialist is declined or unavailable and the diagnosis of external genital warts is certain. The skills and resources to provide a comprehensive sexual health service are available. Treatment options for anogenital warts include (...) : No treatment — one-third of visible warts disappear spontaneously within 6 months. Self-applied treatments (podophyllotoxin 0.5% solution, or 0.15% cream, imiquimod 5% cream, sinecatechins 10% ointment). Ablative methods (such as cryotherapy, excision, and electrocautery) — these should be considered only if the practitioner is appropriately trained. In addition: An explanation of the condition and treatment should be given. Women should be advised that no changes are recommended in the screening intervals

2017 NICE Clinical Knowledge Summaries

107. UK National Guidelines on the Management of Anogenital Warts

and is retrospectively applicable to guidance produced using the processes described in the BASHH Framework for Guideline Development and Assessment dated September 2010. More information on accreditation can be viewed at www.evidence.nhs.uk 2 ? Search strategy OVID/Medline was searched for the years 1966-2013 using keywords "human papillomavirus," "genital warts," "epidemiology," "clinical manifestations," "treatment," "management”. ? Methods Article titles and abstracts were screened for relevance and the full (...) be advisable to take a biopsy for histological verification in cases that do not respond to treatment. Examination of the genitalia and perianal skin is essential to recognise the full extent of the warts. In the presence of perianal warts, a proportion of patients will have warts in the anal canal. If patients have anal symptoms such as irritation or discharge, it is recommended to examine the anal canal. Some patients present with intraepithelial neoplastic lesions in the anogenital region, either

2015 British Association for Sexual Health and HIV

108. Warts and Verrucae

Warts and Verrucae Wart and verruca treatment options | Patient TOPICS Try our Symptom Checker TREATMENT RESOURCES Try our Symptom Checker PROFESSIONAL Upgrade to Patient Pro / / Search Wart and verruca treatment options Authored by Reviewed by Warts are very common and usually harmless. Warts on the feet are called verrucas (or verrucae) and are sometimes painful. Warts and verrucas usually disappear without treatment but can remain for a long time. There are a number of different treatments (...) that can help to get rid of them more quickly. There are three options for the management of : Do not treat them . If warts don't bother you, there is no reason for active treatment. Use home treatment . There are a number of home treatments to try, including: Covering them up (occlusion). Chemical burning (salicylic acid). Freezing (cryotherapy). Liquid nitrogen cryotherapy (intensive freezing) or minor surgery . There is no perfect treatment with no risks so it's important to consider which treatment

2015 SickKids Reports

109. Efficacy and Tolerability of Topical Green Tea Extract (Polyphenon E) Application in a “Therapy-Resistant” Plantar Wart (PubMed)

Efficacy and Tolerability of Topical Green Tea Extract (Polyphenon E) Application in a “Therapy-Resistant” Plantar Wart Plantar warts account for 30% of all cutaneous warts. These lesions could be very painful, especially if the lesion is located over pressure sites such as the metatarsal head. Plantar wart treatment remains a challenging therapeutic problem. A 67-year-old immunocompetent nonsmoking man presented with a large mosaic plantar wart on his right foot. The lesion had been (...) present for 5 years. Several cryotherapy sessions (a total of 6 procedures) had been performed with no success. The lesion was therefore treated with a 5-fluorouracil (5-FU) regimen and then with a topical combination of 5-FU and salicylic acid, but also these approaches failed. At the initial visit, a large (16 cm2) mosaic wart lesion was present. Treatment with topical Polyphenon E, 10%, twice daily was prescribed and started. After 3 months of treatment, the lesion completely disappeared

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2018 Case reports in dermatology

110. Comparison Between Podofilox Topical Gel 0.5% and Allergan's Condylox® Gel 0.5% for External Anogenital Warts

, 2018 Last Update Posted : February 21, 2019 Sponsor: bioRASI, LLC Collaborator: Hyloris Developments SA Information provided by (Responsible Party): bioRASI, LLC Study Details Study Description Go to Brief Summary: A clinical endpoint bioequivalence (BE) study for a Podofilox Gel 0.5% formulation for the treatment of external anogenital warts in comparison to Condylox® Gel 0.5% that follows the study design and recommendations according to Office of Generic Drugs (OGD) of U.S. Food and Drug (...) Administration (FDA) Draft Guidance for Podofilox recommendations Condition or disease Intervention/treatment Phase External Anogenital Warts Drug: Podofilox Gel 0.5% Drug: Condylox Topical Gel 0.5% Drug: Placebo Gel Phase 3 Detailed Description: This is a multicenter, parallel group, randomized, double-blind, placebo-controlled, trial with clinical endpoint comparing Podofilox Topical Gel 0.5% to Condylox® Gel 0.5% and a matching placebo. The study will be conducted among adult male and female patients

2018 Clinical Trials

111. Burn aggravated infected wart in a patient with type 2 diabetes: a medical challenge (PubMed)

of Staphylococcus aureus and Proteus species in culture and sensitivity report; during his travel, he walked barefoot and the infected wart aggravated with severe burn. Patient continued empiric treatment for 14 days. On his arrival, infected wart worsened with dead burnt skin, heavy purulent discharge on plantar region. X-rays revealed marked arthritic changes. Cefepime 500 mg three times a day intravenously was initiated following wound debridement. Patient was switched to moxifloxacin 400 mg once daily (...) Burn aggravated infected wart in a patient with type 2 diabetes: a medical challenge An infectious wart of foot in a patient with diabetics is a medical challenge, and it gets worse when aggravated with burns. We present a case of a 67-year-old Pakistani man, diabetic for 20 years presented at our healthcare centre. While awaiting his culture sensitivity report, he was prescribed an empiric antibiotic therapy. Patient then travelled to Saudi Arabia for pilgrimage 3 days later with growth

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2018 BMJ case reports

112. Epidemiology and Clinical Profile of Cutaneous Warts in Chinese College Students: A Cross-Sectional and Follow-Up Study (PubMed)

students (2.0% vs. 0.9%, P < 0.0001). Of the 215 patients, 66.9% and 62.1% had only one wart and 98.3% and 93.2% had warts <1 cm in diameter, on the hands and feet, respectively. Of the 130 patients with a follow-up visit, 78 did not receive any treatment (44 recovered within 2 years). Patients aged 21-25 compared to those aged ≤20 were more likely to be free of warts (hazard ratio = 1.76; 95% CI, 1.07-2.89), while lower father's education (hazard ratio = 0.19; 95% CI, 0.04-0.98) and poor sleep quality (...) Epidemiology and Clinical Profile of Cutaneous Warts in Chinese College Students: A Cross-Sectional and Follow-Up Study In this study, the hands and feet of 15,384 undergraduate and postgraduate students in 3 colleges in Beijing were examined for the presence of cutaneous warts at college-entry, and those diagnosed with warts were followed up 2-3 years later. We identified totally 215 (1.4%; 95% CI, 1.2-1.6%) students with warts. The prevalence was significantly higher in male than in female

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2018 Scientific reports

113. Anaphylaxis to diphenylcyclopropenone during sensitization for wart treatment—A case report (PubMed)

Anaphylaxis to diphenylcyclopropenone during sensitization for wart treatment—A case report 30306114 2019 02 26 2352-5126 4 9 2018 Oct JAAD case reports JAAD Case Rep Anaphylaxis to diphenylcyclopropenone during sensitization for wart treatment-A case report. 872-873 10.1016/j.jdcr.2018.07.003 Venkatesh Kavya K St. Vincent's Hospital, Sydney, Australia. Yun James J Department of Allergy and Immunology, Royal North Shore Hospital, Sydney, Australia. The University of Sydney, Sydney, Australia (...) . Bakis-Petsoglou Sophie S Hills Dermatology (Private Practice), Sydney, Australia. eng Case Reports 2018 10 03 United States JAAD Case Rep 101665210 2352-5126 DPCP, diphenylcyclopropenone SPT, skin prick testing anaphylaxis diphencyprone diphenylcyclopropenone hypersensitivity verruca verrucae warts 2018 10 12 6 0 2018 10 12 6 0 2018 10 12 6 1 epublish 30306114 10.1016/j.jdcr.2018.07.003 S2352-5126(18)30183-8 PMC6172440 Australas J Dermatol. 1988 Apr;29(1):33-6 2977943 Allergy. 2001 Sep;56(9):850-6

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2018 JAAD Case Reports

114. Condylomata acuminata (anogenital warts) contain accumulations of HIV-1 target cells that may provide portals for HIV transmission. (PubMed)

Condylomata acuminata (anogenital warts) contain accumulations of HIV-1 target cells that may provide portals for HIV transmission. Condylomata acuminata (anogenital warts [AGWs]) are prevalent in human immunodeficiency virus (HIV)-infected individuals and sexually active populations at risk for HIV acquisition and have been associated with HIV transmission. We compared AGW specimens to control tissue specimens for abundance, types, and location of HIV target cells and for susceptibility to HIV (...) in large focal accumulations in the dermis of AGW specimens. Two of 8 AGW specimens versus 0 of 8 control specimens showed robust infection with HIV in vitro.Compared with normal skin, AGWs contain significantly higher concentrations of HIV target cells that may be susceptible to HIV infection. Condylomata may thus promote HIV transmission, especially in the setting of typical lesion vascularity and friability. Prevention or treatment of AGWs may decrease the sexual transmission of HIV.

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2018 Journal of Infectious Diseases

115. Immunotherapy in viral warts with intradermal (PubMed)

with Bacillus Calmette-Guerin. No recurrence was seen after lesions cleared.Patients were not followed up for more than 4 weeks after treatment. We could not estimate the cytokine levels or the peripheral blood mononuclear cell proliferation in response to Bacillus Calmette-Guerin/tuberculin purified protein derivative injections.Both intradermal Bacillus Calmette-Guerin and tuberculin purified protein derivative hold promise in the treatment of viral warts. Bacillus Calmette-Guerin may be more effective (...) Immunotherapy in viral warts with intradermal Current therapeutic modalities for viral warts are mostly ablative and are limited by high recurrence rates besides being unsuitable for numerous lesions. Immunotherapy has the potential to overcome these limitations.The aim of this study was to compare the effectiveness and safety of Bacillus Calmette-Guerin vaccine versus tuberculin purified protein derivative in the immunotherapy of warts.Patients received three doses of 0.1 ml of Bacillus

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2018 Indian journal of dermatology, venereology and leprology Controlled trial quality: predicted high

116. A randomised controlled proof-of-concept trial of digoxin and furosemide in adults with cutaneous warts. (PubMed)

A randomised controlled proof-of-concept trial of digoxin and furosemide in adults with cutaneous warts. Topical ionic contraviral therapy (ICVT) with digoxin and furosemide inhibits the potassium influx on which DNA viruses rely for replication. Therefore, ICVT was hypothesized to be a potential novel treatment for cutaneous warts.To assess the clinical efficacy, safety and tolerability of ICVT in adults with cutaneous warts. The secondary objective was to gain insight into the underlying (...) working mechanism of ICVT.Treatment with ICVT was assessed for efficacy, safety and tolerability in a single- centre, randomized, double-blind, placebo-controlled phase IIA trial. Eighty adult patients with at least two cutaneous warts (plantar or common) were randomized to one of four treatments: digoxin + furosemide (0·125%), digoxin (0·125%), furosemide (0·125%) or placebo. The gel was administered once daily for 42 consecutive days. Predefined statistical analysis was performed with a mixed-model

2018 British Journal of Dermatology Controlled trial quality: predicted high

117. Therapeutic Outcome of Intralesional Immunotherapy in Cutaneous Warts Using the Mumps, Measles, and Rubella Vaccine: A Randomized, Placebo-controlled Trial (PubMed)

Therapeutic Outcome of Intralesional Immunotherapy in Cutaneous Warts Using the Mumps, Measles, and Rubella Vaccine: A Randomized, Placebo-controlled Trial Background: Various treatment modalities have been described in the literature for treating warts, but none thus far have demonstrated optimal results. Recently, the mumps, measles, and rubella (MMR) antigen has gained popularity because of its proven efficacy in the treatment of warts. Aim: The goal was to evaluate the efficacy and safety (...) of intralesional MMR antigen in the treatment of cutaneous warts. Methods: Patients were divided into an MMR (study) group and a normal saline (control) group. Injections were administered into the single largest wart on each patient every two weeks. Follow-up was done at six weeks and 16 weeks after the last injection for any side effects and/or recurrence. Results: Out of 150 patients, 72 received the MMR injection and 50 received normal saline injections. Twenty-eight patients did not complete the study

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2018 The Journal of clinical and aesthetic dermatology Controlled trial quality: uncertain

118. Ano-genital Human Papillomavirus (HPV) Infection, Precancerous Lesions and Genital Warts Among Danish Renal Transplant Recipients

Ano-genital Human Papillomavirus (HPV) Infection, Precancerous Lesions and Genital Warts Among Danish Renal Transplant Recipients Ano-genital Human Papillomavirus (HPV) Infection, Precancerous Lesions and Genital Warts Among Danish Renal Transplant Recipients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have (...) reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Ano-genital Human Papillomavirus (HPV) Infection, Precancerous Lesions and Genital Warts Among Danish Renal Transplant Recipients The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03018327 Recruitment

2017 Clinical Trials

119. How I treat warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome. (PubMed)

How I treat warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome. Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a genetic disease characterized by neutropenia, lymphopenia, susceptibility to infections, and myelokathexis, which describes degenerative changes of mature neutrophils and hyperplasia of bone marrow myeloid cells. Some patients present with hypogammaglobulinemia and/or refractory warts of skin and genitalia. Congenital cardiac (...) , such as development of bronchiectasis, anogenital dysplasia, or invasive cancer. The available therapeutic measures aimed at preventing the risk for infection in WHIM patients are discussed. We critically evaluate the diagnostic criteria of WHIM syndrome, particularly when WHIM syndrome should be suspected in patients with congenital neutropenia and lymphopenia despite the absence of hypogammaglobulinemia and/or warts. Finally, we discuss recent results of trials evaluating plerixafor, a selective antagonist

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2017 Blood

120. Ranpirnase eradicates human papillomavirus in cultured cells and heals anogenital warts in a Phase I study. (PubMed)

Ranpirnase eradicates human papillomavirus in cultured cells and heals anogenital warts in a Phase I study. Human papillomaviruses (HPV), the causative agents of anogenital warts, are the most prevalent sexually transmitted infectious agents, and wart treatment poses a persistent challenge. We assessed the safety and efficacy of treating HPV with ranpirnase, an endoribonuclease from the northern leopard frog that has been used extensively in Phase III oncology trials.As initial verification (...) of ranpirnase antiviral activity, we assessed its ability to eliminate papillomaviruses in cultured cells. To further assess its feasibility for treating anogenital warts in humans, we performed a Phase I study. Forty-two male volunteers with genital/perianal warts were treated topically with three different formulations of 1 mg/ml ranpirnase. Patients were monitored for 8 weeks or until healing. Four patients with HIV were treated in accordance with the compassionate programme but were not evaluated.In

2017 Antiviral Therapy

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