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Wart Treatment

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81. Photothermal therapy enhanced the effectiveness of imiquimod against refractory cutaneous warts through boosting immune responses. (Abstract)

Photothermal therapy enhanced the effectiveness of imiquimod against refractory cutaneous warts through boosting immune responses. Refractory cutaneous warts are difficult to eliminate. In situ photo-immunotherapy (ISPI) is an innovative treatment concept combining local photothermal therapy (PTT) and topical immunotherapy using imiquimod. To compare the efficacy of ISPI vs topical imiquimod alone, a prospective randomized controlled trial was performed with patients suffering from refractory (...) cutaneous warts. In both groups, approximately 50% of the skin surface containing warts was treated for 6 weeks. On the basis of topical imiquimod, ISPI includes an additional 808 nm laser irradiation. Treatment response, temperatures during irradiation and histopathologic examination were evaluated. The complete response rate in the ISPI-group (22/36, 61.1%) was significantly higher than in the imiquimod alone group (11/34, 32.4%). In the ISPI-group, the mean maximum temperature was 44.5 ± 5.1°C

2019 Journal of biophotonics Controlled trial quality: uncertain

82. Efficacy of sinecatechins 10% as proactive sequential therapy of external genital warts after laser CO (Abstract)

Efficacy of sinecatechins 10% as proactive sequential therapy of external genital warts after laser CO External genital warts (EGW) are the most common viral sexually transmitted infection. Ablative treatments like cryotherapy, curettage, and CO2 laser therapies offer rapid onset of effect, fast clearance, and reduction of virus load. However, these procedures are associated with high recurrence rates (RRs) ranging from 20% to 77% in the short and medium terms and do not provide sustained (...) clearance. After laser therapy removal of EGW, an RR up to 77% has been reported. Topical sinecatechins (TS) 10% is a patient-applied regimen for the treatment of EGW with a low RR (<6.5%) at three months after completion of the therapy in the pivotal trials conducted so far. Sinecatechins can be considered a suitable proactive sequential therapy (PST) after ablative strategies to obtain a low RR. So far, no prospective data are available regarding the efficacy of sinecatechins 10% as PST. We evaluated

2019 International journal of STD & AIDS Controlled trial quality: uncertain

83. Intralesional Injection of the Measles-Mumps-Rubella Vaccine into Resistant Palmoplantar Warts: A Randomized Controlled Trial. (Abstract)

Intralesional Injection of the Measles-Mumps-Rubella Vaccine into Resistant Palmoplantar Warts: A Randomized Controlled Trial. Common resistant-to-therapy warts pose a challenge to both clinicians and patients. Among many destructive and immunotherapeutic options, no single, fully effective treatment has been suggested yet. Many investigations, including those using intralesional antigen administrations, have demonstrated that cellular immunity plays a major role in the clearance of human (...) papilloma virus (HPV) infection. The aim of the present study was to evaluate the effects of the intralesional injection of the measles-mumps-rubella (MMR) vaccine into resistant-to- treatment palmoplantar warts and its complications.In this single-blind, randomized, controlled clinical trial, 60 cases with resistant-to-therapy palmoplantar warts referring to the Dermatology Clinic of Bou-Ali Sina Hospital of Sari between June 2015 and 2016 were randomly assigned to 2 equal groups: the MMR Group

2019 Iranian journal of medical sciences Controlled trial quality: uncertain

84. Expression of PD-L1 and PD-1 in Cutaneous Warts. (Abstract)

/8, 63%).This was a retrospective observational study conducted at a single institution.Many cutaneous warts express PD-L1, suggesting that human papillomavirus might use this pathway to promote immune dysfunction. This discovery helps explain the recalcitrance of warts to current therapies and provides a rationale for investigating anti-PD-1 immunotherapy as a potential treatment for warts.Copyright © 2019 American Academy of Dermatology, Inc. All rights reserved. (...) Expression of PD-L1 and PD-1 in Cutaneous Warts. Cutaneous warts have high prevalence and cause significant morbidity. Understanding the mechanisms by which warts evade the immune system could lead to targeted and improved treatments.To determine whether cutaneous warts express programmed cell death ligand 1 (PD-L1) and to characterize the expression of programmed cell death 1 (PD-1) within the immune infiltrate of inflamed lesions.In total, 44 biopsies of cutaneous warts were retrieved from

2019 Journal of American Academy of Dermatology

85. Topical 5-aminolevulinic acid photodynamic therapy for intra anal-rectal warts. (Abstract)

Topical 5-aminolevulinic acid photodynamic therapy for intra anal-rectal warts. Condylomata acuminata(CA) are a common sexually transmitted disease. The recurrence rate of condyloma acuminatum using traditional treatments is higher than that of applying photodynamic therapy, and a variety of adverse reactions after treatment. At the same time, different parts of condyloma acuminatum after treatment recurrence rate is also different, especially for intra anal-rectal warts.To evaluate whether (...) once every week for 4 weeks.After PDT, the complete clearance rate was 76.1%(35 of 46 patients) . At the end of the 12 weeks followed, recurrence occurred in 5 cases. We recorded pain in all 46 patients and the average Visual Analogue Scale(VAS) Pain Score was 6.96 ± 1.41 points.The treatment with PDT is effective in reducing the high rate of recurrence for intra anal- rectal warts. Pain is still a great challenge for the therapy.

2019 Journal of Dermatological Treatment

86. Combined therapy of plantar warts with topical bleomycin and microneedling: a comparative controlled study‏. (Abstract)

Combined therapy of plantar warts with topical bleomycin and microneedling: a comparative controlled study‏. The aim of this study was to assess the efficacy of combination between microneedling with dermapen and topical bleomycin in the treatment of plantar warts in comparison with intralesional bleomycin and intralesional saline (placebo).Fifty-four patients were assigned into three groups, each containing 18 patients. The first group treated by micro-needling phenotype with topical bleomycin (...) at 2 weeks interval, the second group received intralesional bleomycin at 3 weeks interval and the control group was intralesional saline for a maximum of four weeks.Complete clearance of warts in 16 patients in the micro-needling group (88.9%) versus 15 patients (83.3%) in the intralesional bleomycin group versus one patient (5.6%) in the control group‏.Microneedling assisted topical bleomycin spraying seems to be a promising effective and noninvasive therapeutic modality for recalcitrant plantar

2019 Journal of Dermatological Treatment Controlled trial quality: uncertain

87. Infectivity of murine papillomavirus in the surgical byproducts of treated tail warts. (Abstract)

Infectivity of murine papillomavirus in the surgical byproducts of treated tail warts. Human papillomavirus (HPV) is a highly stable DNA virus that causes disease in human organ systems, including the larynx and oropharynx. The treatment of HPV-associated diseases with scalpels, lasers, and other surgical instruments has the potential to release infectious particles, placing healthcare workers at risk. The objectives of this study were to create a reproducible in vivo animal model (...) of papillomavirus infectivity and to compare the infectivity of byproducts of surgically treated mouse papillomavirus (MmuPV1) warts.Animal study.Nude laboratory mice (Mus musculus) with established MmuPV1 tail warts were treated with scalpel excision, potassium titanyl phosphate (KTP) laser ablation, and coblator treatment. Uninfected nude mice were challenged with surgical byproducts, including ablated and heated tissue, and surgical smoke products. The incidence and time course of the appearance of warts

2019 Laryngoscope

88. Warts - anogenital

(for example HIV). Referral is essential if: The diagnosis is uncertain. Malignancy or intraepithelial neoplasia is suspected. The warts are cervical, intrameatal, or intra-anal. Treatment for anogenital warts should only be offered in primary care if: Referral to a sexual health specialist is declined or unavailable and the diagnosis of external genital warts is certain. The skills and resources to provide a comprehensive sexual health service are available. Treatment options for anogenital warts include (...) : No treatment — one-third of visible warts disappear spontaneously within 6 months. Self-applied treatments (podophyllotoxin 0.5% solution, or 0.15% cream, imiquimod 5% cream, sinecatechins 10% ointment). Ablative methods (such as cryotherapy, excision, and electrocautery) — these should be considered only if the practitioner is appropriately trained. In addition: An explanation of the condition and treatment should be given. Women should be advised that no changes are recommended in the screening intervals

2017 NICE Clinical Knowledge Summaries

89. Cryotherapy systems for wart removal: a review of the clinical effectiveness, cost-effectiveness, and guidelines

for Drugs and Technologies in Health (CADTH). Rapid Response. 2014 Authors' conclusions Limited evidence suggested that cryotherapy with liquid nitrogen using a melamine foam sponge (MFS) applicator was superior to cotton wool bud (CWB) applicators for reducing wart size after one treatment, with a lower mean number of treatments at complete remission and fewer adverse events, though the generalizability of these findings to a Canadian context is unclear. There was no evidence identified for the cost (...) -effectiveness comparing different cryotherapy systems. Guidelines suggest first line treatment using cryotherapy with liquid nitrogen every two to three weeks, up to three months for the removal of cutaneous warts. Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Cryotherapy; Humans; Warts Language Published English Country of organisation Canada Province or state Ontario English summary An English language summary is available. Address for correspondence Canadian Agency for Drugs

2014 Health Technology Assessment (HTA) Database.

90. Comparison Between Podofilox Topical Gel 0.5% and Allergan's Condylox® Gel 0.5% for External Anogenital Warts

, 2018 Last Update Posted : February 21, 2019 Sponsor: bioRASI, LLC Collaborator: Hyloris Developments SA Information provided by (Responsible Party): bioRASI, LLC Study Details Study Description Go to Brief Summary: A clinical endpoint bioequivalence (BE) study for a Podofilox Gel 0.5% formulation for the treatment of external anogenital warts in comparison to Condylox® Gel 0.5% that follows the study design and recommendations according to Office of Generic Drugs (OGD) of U.S. Food and Drug (...) Administration (FDA) Draft Guidance for Podofilox recommendations Condition or disease Intervention/treatment Phase External Anogenital Warts Drug: Podofilox Gel 0.5% Drug: Condylox Topical Gel 0.5% Drug: Placebo Gel Phase 3 Detailed Description: This is a multicenter, parallel group, randomized, double-blind, placebo-controlled, trial with clinical endpoint comparing Podofilox Topical Gel 0.5% to Condylox® Gel 0.5% and a matching placebo. The study will be conducted among adult male and female patients

2018 Clinical Trials

91. Condylomata acuminata (anogenital warts) contain accumulations of HIV-1 target cells that may provide portals for HIV transmission. Full Text available with Trip Pro

Condylomata acuminata (anogenital warts) contain accumulations of HIV-1 target cells that may provide portals for HIV transmission. Condylomata acuminata (anogenital warts [AGWs]) are prevalent in human immunodeficiency virus (HIV)-infected individuals and sexually active populations at risk for HIV acquisition and have been associated with HIV transmission. We compared AGW specimens to control tissue specimens for abundance, types, and location of HIV target cells and for susceptibility to HIV (...) in large focal accumulations in the dermis of AGW specimens. Two of 8 AGW specimens versus 0 of 8 control specimens showed robust infection with HIV in vitro.Compared with normal skin, AGWs contain significantly higher concentrations of HIV target cells that may be susceptible to HIV infection. Condylomata may thus promote HIV transmission, especially in the setting of typical lesion vascularity and friability. Prevention or treatment of AGWs may decrease the sexual transmission of HIV.

2018 Journal of Infectious Diseases

92. Epidemiology and Clinical Profile of Cutaneous Warts in Chinese College Students: A Cross-Sectional and Follow-Up Study Full Text available with Trip Pro

students (2.0% vs. 0.9%, P < 0.0001). Of the 215 patients, 66.9% and 62.1% had only one wart and 98.3% and 93.2% had warts <1 cm in diameter, on the hands and feet, respectively. Of the 130 patients with a follow-up visit, 78 did not receive any treatment (44 recovered within 2 years). Patients aged 21-25 compared to those aged ≤20 were more likely to be free of warts (hazard ratio = 1.76; 95% CI, 1.07-2.89), while lower father's education (hazard ratio = 0.19; 95% CI, 0.04-0.98) and poor sleep quality (...) Epidemiology and Clinical Profile of Cutaneous Warts in Chinese College Students: A Cross-Sectional and Follow-Up Study In this study, the hands and feet of 15,384 undergraduate and postgraduate students in 3 colleges in Beijing were examined for the presence of cutaneous warts at college-entry, and those diagnosed with warts were followed up 2-3 years later. We identified totally 215 (1.4%; 95% CI, 1.2-1.6%) students with warts. The prevalence was significantly higher in male than in female

2018 Scientific reports

93. Anaphylaxis to diphenylcyclopropenone during sensitization for wart treatment—A case report Full Text available with Trip Pro

Anaphylaxis to diphenylcyclopropenone during sensitization for wart treatment—A case report 30306114 2019 02 26 2352-5126 4 9 2018 Oct JAAD case reports JAAD Case Rep Anaphylaxis to diphenylcyclopropenone during sensitization for wart treatment-A case report. 872-873 10.1016/j.jdcr.2018.07.003 Venkatesh Kavya K St. Vincent's Hospital, Sydney, Australia. Yun James J Department of Allergy and Immunology, Royal North Shore Hospital, Sydney, Australia. The University of Sydney, Sydney, Australia (...) . Bakis-Petsoglou Sophie S Hills Dermatology (Private Practice), Sydney, Australia. eng Case Reports 2018 10 03 United States JAAD Case Rep 101665210 2352-5126 DPCP, diphenylcyclopropenone SPT, skin prick testing anaphylaxis diphencyprone diphenylcyclopropenone hypersensitivity verruca verrucae warts 2018 10 12 6 0 2018 10 12 6 0 2018 10 12 6 1 epublish 30306114 10.1016/j.jdcr.2018.07.003 S2352-5126(18)30183-8 PMC6172440 Australas J Dermatol. 1988 Apr;29(1):33-6 2977943 Allergy. 2001 Sep;56(9):850-6

2018 JAAD Case Reports

94. Therapeutic Outcome of Intralesional Immunotherapy in Cutaneous Warts Using the Mumps, Measles, and Rubella Vaccine: A Randomized, Placebo-controlled Trial Full Text available with Trip Pro

Therapeutic Outcome of Intralesional Immunotherapy in Cutaneous Warts Using the Mumps, Measles, and Rubella Vaccine: A Randomized, Placebo-controlled Trial Background: Various treatment modalities have been described in the literature for treating warts, but none thus far have demonstrated optimal results. Recently, the mumps, measles, and rubella (MMR) antigen has gained popularity because of its proven efficacy in the treatment of warts. Aim: The goal was to evaluate the efficacy and safety (...) of intralesional MMR antigen in the treatment of cutaneous warts. Methods: Patients were divided into an MMR (study) group and a normal saline (control) group. Injections were administered into the single largest wart on each patient every two weeks. Follow-up was done at six weeks and 16 weeks after the last injection for any side effects and/or recurrence. Results: Out of 150 patients, 72 received the MMR injection and 50 received normal saline injections. Twenty-eight patients did not complete the study

2018 The Journal of clinical and aesthetic dermatology Controlled trial quality: uncertain

95. Efficacy and Tolerability of Topical Green Tea Extract (Polyphenon E) Application in a “Therapy-Resistant” Plantar Wart Full Text available with Trip Pro

Efficacy and Tolerability of Topical Green Tea Extract (Polyphenon E) Application in a “Therapy-Resistant” Plantar Wart Plantar warts account for 30% of all cutaneous warts. These lesions could be very painful, especially if the lesion is located over pressure sites such as the metatarsal head. Plantar wart treatment remains a challenging therapeutic problem. A 67-year-old immunocompetent nonsmoking man presented with a large mosaic plantar wart on his right foot. The lesion had been (...) present for 5 years. Several cryotherapy sessions (a total of 6 procedures) had been performed with no success. The lesion was therefore treated with a 5-fluorouracil (5-FU) regimen and then with a topical combination of 5-FU and salicylic acid, but also these approaches failed. At the initial visit, a large (16 cm2) mosaic wart lesion was present. Treatment with topical Polyphenon E, 10%, twice daily was prescribed and started. After 3 months of treatment, the lesion completely disappeared

2018 Case reports in dermatology

96. Burn aggravated infected wart in a patient with type 2 diabetes: a medical challenge Full Text available with Trip Pro

of Staphylococcus aureus and Proteus species in culture and sensitivity report; during his travel, he walked barefoot and the infected wart aggravated with severe burn. Patient continued empiric treatment for 14 days. On his arrival, infected wart worsened with dead burnt skin, heavy purulent discharge on plantar region. X-rays revealed marked arthritic changes. Cefepime 500 mg three times a day intravenously was initiated following wound debridement. Patient was switched to moxifloxacin 400 mg once daily (...) Burn aggravated infected wart in a patient with type 2 diabetes: a medical challenge An infectious wart of foot in a patient with diabetics is a medical challenge, and it gets worse when aggravated with burns. We present a case of a 67-year-old Pakistani man, diabetic for 20 years presented at our healthcare centre. While awaiting his culture sensitivity report, he was prescribed an empiric antibiotic therapy. Patient then travelled to Saudi Arabia for pilgrimage 3 days later with growth

2018 BMJ case reports

97. Immunotherapy in viral warts with intradermal Full Text available with Trip Pro

with Bacillus Calmette-Guerin. No recurrence was seen after lesions cleared.Patients were not followed up for more than 4 weeks after treatment. We could not estimate the cytokine levels or the peripheral blood mononuclear cell proliferation in response to Bacillus Calmette-Guerin/tuberculin purified protein derivative injections.Both intradermal Bacillus Calmette-Guerin and tuberculin purified protein derivative hold promise in the treatment of viral warts. Bacillus Calmette-Guerin may be more effective (...) Immunotherapy in viral warts with intradermal Current therapeutic modalities for viral warts are mostly ablative and are limited by high recurrence rates besides being unsuitable for numerous lesions. Immunotherapy has the potential to overcome these limitations.The aim of this study was to compare the effectiveness and safety of Bacillus Calmette-Guerin vaccine versus tuberculin purified protein derivative in the immunotherapy of warts.Patients received three doses of 0.1 ml of Bacillus

2018 Indian journal of dermatology, venereology and leprology Controlled trial quality: predicted high

98. A randomised controlled proof-of-concept trial of digoxin and furosemide in adults with cutaneous warts. Full Text available with Trip Pro

A randomised controlled proof-of-concept trial of digoxin and furosemide in adults with cutaneous warts. Topical ionic contraviral therapy (ICVT) with digoxin and furosemide inhibits the potassium influx on which DNA viruses rely for replication. Therefore, ICVT was hypothesized to be a potential novel treatment for cutaneous warts.To assess the clinical efficacy, safety and tolerability of ICVT in adults with cutaneous warts. The secondary objective was to gain insight into the underlying (...) working mechanism of ICVT.Treatment with ICVT was assessed for efficacy, safety and tolerability in a single- centre, randomized, double-blind, placebo-controlled phase IIA trial. Eighty adult patients with at least two cutaneous warts (plantar or common) were randomized to one of four treatments: digoxin + furosemide (0·125%), digoxin (0·125%), furosemide (0·125%) or placebo. The gel was administered once daily for 42 consecutive days. Predefined statistical analysis was performed with a mixed-model

2018 British Journal of Dermatology Controlled trial quality: predicted high

99. Cost analysis of Human Papillomavirus-related cervical diseases and genital warts in Swaziland. Full Text available with Trip Pro

and treatment in Swaziland. All identifiable direct medical costs were considered for cervical lesions, cervical cancer and genital warts, which were primary diagnoses during 2015. A mix of bottom up micro-costing ingredients approach and top-down approaches was used to collect data on costs. All costs were computed at the price level of 2015 and converted to dollars ($).The total annual estimated direct medical cost associated with screening, managing and treating cervical lesions, CC and genital warts (...) in Swaziland was $16 million. The largest cost in the analysis was estimated for treatment of high-grade cervical lesions and cervical cancer representing 80% of the total cost ($12.6 million). Costs for screening only represented 5% of the total cost ($0.9 million). Treatment of genital warts represented 6% of the total cost ($1million).According to the cost estimations in this study, the economic burden of HPV-related cervical diseases and genital warts represents a major public health issue in Swaziland

2017 PLoS ONE

100. Intralesional immunotherapy for the viral warts

Intralesional immunotherapy for the viral warts Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith (...) true for data from animal studies, which generally include various species, strains and treatment regimes, for which different true effects are likely to exist. The random-effects model takes into account both the within-study (sampling error) and between-study (differences in the true effect size) variance. Should the excessive between-study variance be very low or zero, the random-effects model will yield the same results as the fixed-effect model. For further details, see the and to pre-clinical

2020 PROSPERO

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