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Wart Treatment

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61. The Successful Use of a Novel Microwave Device in the Treatment of a Plantar Wart (PubMed)

The Successful Use of a Novel Microwave Device in the Treatment of a Plantar Wart Plantar warts, caused by the human papilloma virus (HPV), are a commonly encountered condition presenting in clinic. In adults, an array of various therapies exists, frequently with modest results particularly with plantar lesions. Microwaves have had limited uses for medical purposes. Recently a new portable microwave device has been approved for the treatment of skin lesions. Prior research has demonstrated (...) immuno-stimulatory effects against HPV infection. We report the application of a novel portable medical microwave unit to treat a long-standing plantar wart which had failed to respond to other treatment modalities.

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2017 Case reports in dermatology

62. Successful treatment of plantar warts with intralesional bleomycin and electroporation: pilot prospective study (PubMed)

Successful treatment of plantar warts with intralesional bleomycin and electroporation: pilot prospective study Numerous studies have been performed to evaluate the efficacy of intralesional bleomycin for the treatment of warts with inconsistent result. Nevertheless, it is well known that the cytotoxicity of bleomycin can be enhanced in vivo by 300 to 700-fold by electroporation.In this article, we present an interventional, one-center, prospective case series, clinical trial (...) of the effectiveness of intralesional bleomycin combined with electroporation for the treatment of plantar warts, in comparison to the use of intralesional bleomycin alone.The study's cohort included 12 men and 10 women, with a mean age of 53.8 years. A total of 22 warts were treated. In dividing the patients in two groups (complete remission against all the others) and analyzing the different outcomes in the two arms of patients, a statistical significant difference was found (p=0.0015), proving a greater

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2017 Dermatology practical & conceptual

63. An expert system for selecting wart treatment method. (PubMed)

An expert system for selecting wart treatment method. As benign tumors, warts are made through the mediation of Human Papillomavirus (HPV) and may grow on all parts of body, especially hands and feet. There are several treatment methods for this illness. However, none of them can heal all patients. Consequently, physicians are looking for more effective and customized treatments for each patient. They are endeavoring to discover which treatments have better impacts on a particular patient (...) . The aim of this study is to identify the appropriate treatment for two common types of warts (plantar and common) and to predict the responses of two of the best methods (immunotherapy and cryotherapy) to the treatment. As an original work, the study was conducted on 180 patients, with plantar and common warts, who had referred to the dermatology clinic of Ghaem Hospital, Mashhad, Iran. In this study, 90 patients were treated by cryotherapy method with liquid nitrogen and 90 patients

2017 Computers in biology and medicine Controlled trial quality: uncertain

64. Immune Modulation and Treatment of Human Papilloma Virus-Related Warts with Energetics of Living Systems Acupuncture (PubMed)

Immune Modulation and Treatment of Human Papilloma Virus-Related Warts with Energetics of Living Systems Acupuncture Background: Cutaneous warts are small skin lesions formed as a result of infection by the human papilloma virus (HPV). In the lesion, viral manipulation creates a microenvironment that favors virus survival and reproduction. Most lesions eventually regress, probably as a result of a Th1-mediated immune response. However, some warts fail to regress and become persistent. Objective (...) : The efficacy of treatment of persistent HPV-caused warts with Energetics of Living Systems acupuncture and monitored immune system involvement was tested. Methods: Eighteen patients with persistent warts were recruited for the study; 9 received acupuncture treatment and 9 received placebo. Each patient was treated 4 times. Results: Clinical success was defined as total clearance of all lesions with no recurrence for 3 months. In the treatment group, clinical success was 36.6% versus 0% in the placebo group

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2017 Medical Acupuncture Controlled trial quality: uncertain

65. Real versus sham proximal biofield therapy in the treatment of warts of the hands and feet in adults: study protocol for a randomized controlled trial (MAGNETIK study) (PubMed)

Real versus sham proximal biofield therapy in the treatment of warts of the hands and feet in adults: study protocol for a randomized controlled trial (MAGNETIK study) Despite the lack of scientific studies on biofield therapies, they are widely acclaimed by patients. The mechanisms of action are not explained by current allopathic medical approaches. Warts are common and contagious viral lesions that may be refractory to standard dermatologic treatments such as cryotherapy, laser therapy (...) , and keratolytic ointments. Biofield therapies are efficient in various pathologies. Their ability to treat warts has never been demonstrated in a scientific study with a robust methodology. Patients with refractory warts often place their trust in these alternative therapies because of the poor results obtained from traditional medicine. We propose a prospective, randomized, single-blind, assessor-blind trial to evaluate the efficacy of treatment of warts by biofield therapy.Subjects with warts on their feet

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2017 Trials Controlled trial quality: predicted high

66. Evaluation of the efficacy and safety of oral isotretinoin versus topical isotretinoin in the treatment of plane warts: a randomized open trial. (PubMed)

Evaluation of the efficacy and safety of oral isotretinoin versus topical isotretinoin in the treatment of plane warts: a randomized open trial. Plane warts are a common therapeutic problem. Our aim was to assess the efficacy and safety of oral versus topical isotretinoin in the treatment of plane warts.Forty patients with multiple plane warts were randomized into two groups. Group A was treated with oral isotretinoin capsules in the dose of 0.5 mg/kg/d and Group B with topical isotretinoin (...) 0.05% in gel formulation once daily at night. Treatment was given to the patients for 3 months or until the complete clearance of lesions, whichever was earlier. Patients with complete response were followed up monthly for 4 months to record the relapse rate.Results were analyzed in 16 patients of Group A and 13 patients of Group B. At the end of 3 months of therapy, 11 (69%) patients in Group A had complete remission whereas five (31%) had partial remission. In Group B, at the end of study, five

2017 International Journal of Dermatology Controlled trial quality: uncertain

67. Morphological characteristics and HPV genotype predict the treatment response in cutaneous warts. (PubMed)

Morphological characteristics and HPV genotype predict the treatment response in cutaneous warts. Cutaneous warts have a cure rate after therapy of no more than approximately 50%. Recently, we developed and validated a standard assessment tool for warts (Cutaneous WARTS diagnostic tool, CWARTS) based on phenotypical characteristics.To assess whether patient and morphological wart characteristics predict the human papillomavirus (HPV) type in a specific wart and whether these characteristics (...) as well as the HPV type predict a favourable treatment response.Photographs were used to score nine morphological wart characteristics using the newly developed CWARTS tool. Genotyping of 23 wart-associated HPV types was performed using the hyperkeratotic skin lesion-polymerase chain reaction/multiplex genotyping assay. The results were correlated with a favourable response to treatment with monochloroacetic acid, cryotherapy or a combination of cryotherapy and salicylic acid. Odds ratios were

2017 British Journal of Dermatology Controlled trial quality: uncertain

68. Efficacy and Safety of Three Cryotherapy Devices for Wart Treatment: A Randomized, Controlled, Investigator-Blinded, Comparative Study (PubMed)

Efficacy and Safety of Three Cryotherapy Devices for Wart Treatment: A Randomized, Controlled, Investigator-Blinded, Comparative Study Cutaneous warts are common skin lesions, caused by human papillomavirus. For years, liquid nitrogen is the cryogen of choice for wart treatment. Alternatively, several cryogenic devices for home treatment are commercially available. The present trial assessed efficacy and safety of a novel nitrous oxide-based cryogenic device for home use (EndWarts Freeze® (...) in Europe, Compound W® Nitro-Freeze in the USA).This investigator-blinded, controlled, randomized study compared the nitrous oxide device (test product) with a dimethylether propane-based product (Wartner®; comparator 1). Subjects with common or plantar warts (50/50 ratio) were randomized into two groups (n = 58, test product; n = 40, comparator 1). Sequentially, an extra treatment arm (n = 40) was added to compare with a dimethylether-based product with metal nib (Wortie®; comparator 2). Main objective

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2017 Dermatology and therapy Controlled trial quality: uncertain

69. Intralesional immunotherapy compared to cryotherapy in the treatment of warts. (PubMed)

Intralesional immunotherapy compared to cryotherapy in the treatment of warts. Warts are the most common clinical manifestation of the human papilloma-virus infection in the skin and mucous membranes. In spite of the various therapeutic modalities for nongenital skin warts, there is still no single method to be used as an approved treatment. In this study, we compared the efficacy of immunotherapy and cryotherapy on wart lesions.Sixty patients with verruca vulgaris and plantar warts were (...) . Immunotherapy was well-tolerated except for the pain during injection that was the most common side effect.Intralesional immunotherapy is an effective treatment of warts. This method has a better therapeutic response, needs fewer sessions, and is capable of treating distant warts.© 2017 The International Society of Dermatology.

2017 International Journal of Dermatology Controlled trial quality: uncertain

70. Functional characterization of CD4 and CD8 T cell responses among human papillomavirus infected patients with ano-genital warts (PubMed)

for the treating physician. The conventional treatment options are targeted only to the local site of warts. There is no systemic treatment modality as there is limited understanding of the disease immune-pathogenesis. The role of cell-mediated immunity in combating HPV infection is not clearly defined. Hence the present study is aimed at investigating the CD4+ T helper (Th1 and Th2) and CD8+ T cell responses among wart patients. In this study, we compared HPV6 and HPV11 antigen-specific T cell responses among (...) function correlated with poor wart clearance. Our findings open future avenues for exploring potential immunomodulation strategies as an adjunct to standard treatment for better management of these patients and prevention of recurrence.

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2017 Virusdisease

71. Could the HPV vaccine prevent the recurrence of ano-genital warts?

Could the HPV vaccine prevent the recurrence of ano-genital warts? Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g (...) true for data from animal studies, which generally include various species, strains and treatment regimes, for which different true effects are likely to exist. The random-effects model takes into account both the within-study (sampling error) and between-study (differences in the true effect size) variance. Should the excessive between-study variance be very low or zero, the random-effects model will yield the same results as the fixed-effect model. For further details, see the and to pre-clinical

2019 PROSPERO

72. A systematic review and meta-analysis of acupuncture for flat warts

A systematic review and meta-analysis of acupuncture for flat warts Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g (...) true for data from animal studies, which generally include various species, strains and treatment regimes, for which different true effects are likely to exist. The random-effects model takes into account both the within-study (sampling error) and between-study (differences in the true effect size) variance. Should the excessive between-study variance be very low or zero, the random-effects model will yield the same results as the fixed-effect model. For further details, see the and to pre-clinical

2019 PROSPERO

73. Cryotherapy plus oral zinc sulfate versus cryotherapy plus placebo to treat common warts: A double blind, randomized, placebo-controlled trial (PubMed)

Cryotherapy plus oral zinc sulfate versus cryotherapy plus placebo to treat common warts: A double blind, randomized, placebo-controlled trial Cutaneous warts are caused by a small group of specific types of human papillomaviruses. Cryotherapy is a highly effective treatment for patients with viral warts; however, it is a painful method and usually requires several treatment sessions. Zinc is a trace element with many proven effects on the immune system.Our aim was to assess the efficacy (...) and safety of oral zinc sulfate in the treatment and recurrence rate of common warts.Eighty-three patients with common warts participated in this double-blind, randomized, placebo-controlled trial. In both groups, three sessions of liquid nitrogen cryotherapy were performed for up to 2 months with 3-week intervals. The treatment group (n = 45) received oral zinc sulfate capsules in a dose of 10 mg/kg per day up to 600 mg day. The control group (n = 38) was provided with placebo of similar appearance

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2017 International journal of women's dermatology Controlled trial quality: predicted high

74. Randomised controlled trial: Cryotherapy for plantar warts more costly but no more effective than salicylic acid self-treatment

Randomised controlled trial: Cryotherapy for plantar warts more costly but no more effective than salicylic acid self-treatment Cryotherapy for plantar warts more costly but no more effective than salicylic acid self-treatment | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username (...) and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Cryotherapy for plantar warts more costly but no more effective than salicylic acid self-treatment Article Text Therapeutics Randomised controlled trial Cryotherapy

2012 Evidence-Based Medicine (Requires free registration)

75. Infectivity of murine papillomavirus in the surgical byproducts of treated tail warts. (PubMed)

Infectivity of murine papillomavirus in the surgical byproducts of treated tail warts. Human papillomavirus (HPV) is a highly stable DNA virus that causes disease in human organ systems, including the larynx and oropharynx. The treatment of HPV-associated diseases with scalpels, lasers, and other surgical instruments has the potential to release infectious particles, placing healthcare workers at risk. The objectives of this study were to create a reproducible in vivo animal model (...) of papillomavirus infectivity and to compare the infectivity of byproducts of surgically treated mouse papillomavirus (MmuPV1) warts.Animal study.Nude laboratory mice (Mus musculus) with established MmuPV1 tail warts were treated with scalpel excision, potassium titanyl phosphate (KTP) laser ablation, and coblator treatment. Uninfected nude mice were challenged with surgical byproducts, including ablated and heated tissue, and surgical smoke products. The incidence and time course of the appearance of warts

2019 Laryngoscope

76. Topical 5-aminolevulinic acid photodynamic therapy for intra anal-rectal warts. (PubMed)

Topical 5-aminolevulinic acid photodynamic therapy for intra anal-rectal warts. Condylomata acuminata(CA) are a common sexually transmitted disease. The recurrence rate of condyloma acuminatum using traditional treatments is higher than that of applying photodynamic therapy, and a variety of adverse reactions after treatment. At the same time, different parts of condyloma acuminatum after treatment recurrence rate is also different, especially for intra anal-rectal warts.To evaluate whether (...) once every week for 4 weeks.After PDT, the complete clearance rate was 76.1%(35 of 46 patients) . At the end of the 12 weeks followed, recurrence occurred in 5 cases. We recorded pain in all 46 patients and the average Visual Analogue Scale(VAS) Pain Score was 6.96 ± 1.41 points.The treatment with PDT is effective in reducing the high rate of recurrence for intra anal- rectal warts. Pain is still a great challenge for the therapy.

2019 Journal of Dermatological Treatment

77. Position statement for the diagnosis and management of anogenital warts. (PubMed)

warts should use immunotherapy for 2 months followed by ablation and a second 2-month course of immunotherapy. Guidance for daily practice situations and the subsequent action that can be taken, as well as an algorithm for treatment of large warts, were also created.The guidance provided will help physicians with the diagnosis and management of AGW in order to improve the health and quality of life of patients with AGW.© 2019 The Authors Journal of the European Academy of Dermatology and Venereology (...) Position statement for the diagnosis and management of anogenital warts. Anogenital warts (AGW) can cause economic burden on healthcare systems and are associated with emotional, psychological and physical issues.To provide guidance to physicians on the diagnosis and management of AGW.Fourteen global experts on AGW developed guidance on the diagnosis and management of AGW in an effort to unify international recommendations. Guidance was developed based on published international and national

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2019 Journal of the European Academy of Dermatology and Venereology

78. Serum retinol-binding protein: a novel biomarker for recalcitrant cutaneous warts. (PubMed)

Serum retinol-binding protein: a novel biomarker for recalcitrant cutaneous warts. Cutaneous viral warts are benign epidermal proliferations caused by human papillomaviruses (HPVs). Despite treatment, a significant proportion of warts fail to resolve, becoming recalcitrant. Vitamin A (retinol) may disrupt the interplay of HPV replication and epithelial cell differentiation, allowing normal tissue to replace warts. Circulating retinol-binding protein (RBP) concentrations highly correlate (...) with retinol levels.We aimed at evaluation of serum RBP level in patients with recalcitrant cutaneous warts in order to assess its correlation with disease pathogenesis.Serum RBP level was measured by an ELISA technique in 50 patients with recalcitrant cutaneous warts and 30 apparently healthy controls.Serum RBP level was significantly lower in patients with recalcitrant warts than the control group (P < 0.001). However, it did not differ regarding different clinical parameters in studied patients (P

2019 International Journal of Dermatology

79. Risk factors for cutaneous warts and the influence factors of curative effect of 5-flurouracil therapy in southern China. (PubMed)

Risk factors for cutaneous warts and the influence factors of curative effect of 5-flurouracil therapy in southern China. Background: To systematically explore the risk factors of cutaneous warts and influence factor for the effectiveness of 5-fluorouracil (5-FU). Methods: This is a case-control study of 408 cutaneous warts patients and 408 controls of Chinese Han population in southern China. In addition, 244 patients who presented with an initial episode of warts without treatment were (...) and twenty-seven patients in 244 (93.03%) were successfully treated with 5-FU. Multivariate analysis indicated that smoking, alcohol intake, severe psychological stress, more than six months' duration of cutaneous warts, lesions on foot and warts diameter ≥5 mm adversely affected the effectiveness of 5-FU. Conclusions: The newly identified risk factors for cutaneous warts and influence factors for efficacy of 5-FU provided clues for warts prevention and treatment of Chinese Han population.

2019 Journal of Dermatological Treatment

80. Role of mannose binding lectin in response to candida antigen immunotherapy of warts. (PubMed)

Role of mannose binding lectin in response to candida antigen immunotherapy of warts. Background: Warts is the commonest cutaneous manifestation of human papillomavirus (HPV) infection. Intralesional Candida antigen immunotherapy is used for wart treatment. Aim: To identify the role of mannose binding lectin (MBL) in susceptibility to HPV infection and to explore the relationship between MBL and response to intralesional Candida antigen immunotherapy of wart. Patients and methods: A case (...) -control study was enrolled with 96 participants; 48 wart cases and 48 healthy controls. MBL serum level assay baseline and after six settings of intralesional candida antigen injection was done by ELISA technique. MBL2 gene exon 1 codon 54 polymorphism was detected by using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR). Results: A statistically significant difference in MBL serum level between wart cases and controls was found. An association between MBL2 exon1 codon 54

2019 Journal of Dermatological Treatment

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