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Wart Treatment

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41. Treatment of Multiple-Resistant and/or Recurrent Cutaneous Warts With Squaric Acid Dibutylester: A Randomized, Double-blind, Vehicle-controlled Clinical Trial. (PubMed)

Treatment of Multiple-Resistant and/or Recurrent Cutaneous Warts With Squaric Acid Dibutylester: A Randomized, Double-blind, Vehicle-controlled Clinical Trial. Contact immunotherapy with squaric acid dibutylester (SADBE) for cutaneous warts has been reported to be effective, although no controlled studies are available so far.The aim of this study was to evaluate the efficacy of SADBE on cutaneous warts by a randomized, double-blind, vehicle-controlled, clinical trial.Thirty-six patients were (...) randomly assigned to SADBE (18 cases) or vehicle (18 cases) group. At 8 weeks, subjects were clinically evaluated for number/size reduction rate and for Investigator Global Assessment. Those who showed improvement extended therapy up to 40 weeks, whereas those who showed unresponsiveness were either switched to SADBE application for up to 48 weeks (if in the vehicle group) or withdrawn from the study (if under SADBE).At 8 weeks, a significant reduction in wart number (P = 0.020) and size (P = 0.010

2018 Dermatitis : contact, atopic, occupational, drug Controlled trial quality: uncertain

42. The efficacy and safety of other cryotherapy compounds for the treatment of genital warts: A randomized controlled trial. (PubMed)

The efficacy and safety of other cryotherapy compounds for the treatment of genital warts: A randomized controlled trial. Cryotherapy using Wartner compound that contains a mixture of dimethyl ether (75%) and propane (25%) has been recently reported as an effective treatment for warts. The present study aimed to evaluate the safety and efficacy of Wartner in male patients with genital warts.A Phase II parallel-randomized clinical trial was performed on 16 Iranian men affected by genital warts (...) who were referred to a dermatology clinic at Tehran University of Medical Sciences. Two genital warts of each patient were selected and randomly assigned to receive either Wartner (intervention) or liquid nitrogen (control).Two weeks after the treatment, the sizes of the lesions in control and intervention groups decreased by 17.87 ± 2.14 mm2 and 15.81 ± 1.80 mm2, respectively (p = .299). Fourteen days after a single session of treatment, 81% of lesions in the control group and 50% in the Wartner

2018 Journal of Dermatological Treatment Controlled trial quality: uncertain

43. Cryotherapy versus CO2 laser in the treatment of plantar warts: a randomized controlled trial (PubMed)

Cryotherapy versus CO2 laser in the treatment of plantar warts: a randomized controlled trial Warts are one of the most common infections in humans. Plantar warts are a subtype of non-genital warts, and several procedures and topical treatments have been used in its treatment. Cryotherapy is one of the most popular modalities, but it is time-consuming and remission rates vary in different studies. CO2 laser was the first laser used for treating warts. To date, no clinical trial has been done (...) to compare CO2 laser with cryotherapy in the treatment of plantar warts.This randomized controlled trial was performed in order to compare the efficacy and number of sessions needed to treat plantar warts in 60 patients who had received no previous treatment in the previous 3 months. They were randomly allocated to the cryotherapy or CO2 laser group. The number of sessions needed for response and the recurrence rate after a 3-month follow-up was compared in the 2 groups.Sixty patients with plantar warts

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2018 Dermatology practical & conceptual Controlled trial quality: uncertain

44. Evaluation of intralesional injection of bleomycin in the treatment of plantar warts: clinical and dermoscopic evaluation. (PubMed)

Evaluation of intralesional injection of bleomycin in the treatment of plantar warts: clinical and dermoscopic evaluation. Treatment of plantar warts is difficult and requires multiple treatments, and they are more refractory to treatment than common warts. Intralesional bleomycin has been used in the treatment of warts with varying degrees of success.The aim of the present work is to evaluate the efficacy of intralesional injection of bleomycin in the treatment of plantar warts based (...) on clinical and dermoscopic observations.Bleomycin (1 mg/ml) was injected intralesionally into the pared plantar wart every 2 weeks for a maximum of four sessions. Patients were followed both clinically and by the use of dermoscope.The cure rate of plantar warts treated with bleomycin was 69.3% with minimal and tolerable side effects.Intralesional injection of bleomycin is an effective and safe treatment of plantar warts. Dermoscope is recommended in the evaluation of treatment success, as it can

2018 International Journal of Dermatology Controlled trial quality: uncertain

45. Cantharidin is Superior to Trichloroacetic Acid for the Treatment of Non-mucosal Genital Warts: A Pilot Randomized Controlled Trial (PubMed)

Cantharidin is Superior to Trichloroacetic Acid for the Treatment of Non-mucosal Genital Warts: A Pilot Randomized Controlled Trial Condyloma Acuminatum is a sexually transmitted viral disease caused by the human papilloma virus (HPV). It is the most common viral sexually transmitted disease. In this randomized controlled trial, cantharidin was found to be more effective and better tolerated than trichloroacetic acid for the treatment of these lesions. Patients treated with cantharidin healed (...) with less scarring than those treated with TCA (P<0.034), had less pain during treatment (P<0.01), and required fewer treatments to eradicate warts (P<0.01) when compared to Trichloroacetic acid.

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2018 Clinical and experimental obstetrics & gynecology Controlled trial quality: uncertain

46. Comparative Clinical Efficacy between Electrodesiccation with Curettage and Application of 80% Phenol Solution in Treatment of Common Warts (PubMed)

Comparative Clinical Efficacy between Electrodesiccation with Curettage and Application of 80% Phenol Solution in Treatment of Common Warts Common warts are skin diseases caused by human papillomavirus. Several treatment modalities available for common warts, two of them are electrodesiccation with curettage and application of 80% phenol solution.This study aims to compare clinical efficacy between these two modalities.Open clinical trial was conducted at Dr Pirngadi General Hospital Medan (...) and H. Adam Malik General Hospital Medan from February to June 2013 on 17 patients with multiple common warts. Both treatments began and applied simultaneously on the same day on each patient.Cure rate was higher in electrodesiccation with curettage (76.5%, 100%) compared to the application of 80% phenol solution (11.8%, 64.7%) on three weeks and six weeks of follow up. Statistical analysis showed a significant difference of common warts cure rate between electrodesiccation with curettage

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2018 Open access Macedonian journal of medical sciences

47. Green tea leaf extract (Catephen) - cutaneous treatment of external genital and perianal warts (condylomata acuminata

Green tea leaf extract (Catephen) - cutaneous treatment of external genital and perianal warts (condylomata acuminata AWMSG SECRETARIAT ASSESSMENT REPORT Green tea leaf extract (Catephen ® ) 10% Ointment Reference number: 2739 FULL SUBMISSION This report has been prepared by the All Wales Therapeutics and Toxicology Centre (AWTTC), in collaboration with the Centre for Health Economics and Medicines Evaluation, Bangor University. Please direct any queries to AWTTC: All Wales Therapeutics (...) This assessment report is based on evidence submitted by Kora Healthcare 1 . 1.0 PRODUCT DETAILS Licensed indication under consideration Green tea leaf extract (Catephen ® ) for the cutaneous treatment of external genital and perianal warts (condylomata acuminata) in immunocompetent patients from the age of 18 years. Dosing Up to 250 mg Catephen ® ointment as total single dose, corresponding to about 0.5 cm of ointment strand to be applied three times per day to all external genital and perianal warts (750 mg

2016 All Wales Medicines Strategy Group

48. Acid, freeze, or duct tape: What works best for common warts?

24, 2016 Acid, freeze, or duct tape: What works best for common warts? Clinical Question: What is the efficacy of commonly used treatments for non-genital warts? Bottom-line: Highest quality primary care evidence finds warts resolve with cryotherapy (39%) and salicylic acid (24%) more than no treatment (16%) at 13 weeks. Cryotherapy has more pain and blistering (up to ~80%), but greater patient satisfaction (~70%). Evidence for duct tape is limited and inconsistent. Evidence: • Highest-quality (...) primary care Randomized Controlled Trial (RCT): 1 240 children and adults, new warts, cryotherapy (2-10 seconds via cotton applicator three times every two weeks), daily 40% salicylic acid (SA), or no treatment. Cure at 13 weeks: o All warts: Cryotherapy 39%, SA 24%, no treatment 16%. ? Versus no treatment: SA Number Needed to Treat (NNT)=13, cryotherapy NNT=5. o Plantar warts: Cryotherapy 30%, SA 33%, no treatment 23% (none statistically significant): ? No patient >12 years old had spontaneous

2016 Tools for Practice

49. Reply to "Topical ionic contra-viral therapy comprised of digoxin and furosemide as a potential novel treatment approach for common warts". (PubMed)

Reply to "Topical ionic contra-viral therapy comprised of digoxin and furosemide as a potential novel treatment approach for common warts". 29055137 2018 03 25 1468-3083 32 4 2018 Apr Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Reply to 'Topical ionic contra-viral therapy comprised of digoxin and furosemide as a potential novel treatment approach for common warts'. e156-e157 10.1111/jdv.14645 Abdelmaksoud A A Mansoura Dermatology

2017 Journal of the European Academy of Dermatology and Venereology

50. Reply to correspondence 'Topical ionic contra viral therapy comprised of digoxin and furosemide as a potential novel treatment approach for common warts'. (PubMed)

Reply to correspondence 'Topical ionic contra viral therapy comprised of digoxin and furosemide as a potential novel treatment approach for common warts'. 29057503 2018 03 25 1468-3083 32 4 2018 Apr Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Reply to correspondence 'Topical ionic contra-viral therapy comprised of digoxin and furosemide as a potential novel treatment approach for common warts '. e156 10.1111/jdv.14643 van der Kolk T T

2017 Journal of the European Academy of Dermatology and Venereology

51. Topical ionic contra viral therapy comprised of digoxin and furosemide as a potential novel treatment approach for common warts. (PubMed)

Topical ionic contra viral therapy comprised of digoxin and furosemide as a potential novel treatment approach for common warts. DNA viruses such as HPV rely on K+ influx for replication. Both digoxin and furosemide inhibit the K+ influx by interacting with cell membrane ion co-transporters (Na+ /K+ -ATPase and Na+ -K+ -2Cl- co-transporter-1, respectively). We therefore hypothesized that these two compounds in a topical formulation may be valuable in the treatment of HPV-induced warts. This new (...) for 7 consecutive days on their lower back to assess safety and systemic exposure. Two warts were treated with 10 mg each and two served as negative controls to obtain preliminary evidence of treatment effect.ICVT was well tolerated topically, and there was no evidence of systemic exposure of digoxin or furosemide. There were no clinical relevant safety findings and no serious adverse events (SAEs). A rapid and statistically significant reduction in diameter, height and volume of the warts

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2017 Journal of the European Academy of Dermatology and Venereology

52. Adjuvant treatment of anogenital warts with systemic interferon: a systematic review and meta-analysis. (PubMed)

Adjuvant treatment of anogenital warts with systemic interferon: a systematic review and meta-analysis. Interferons are natural messenger proteins that are used to treat various disease entities. Due to their immunomodulating, antiviral and antiproliferative effects, the systemic administration of interferons after ablative treatment for anogenital warts (AGWs) has been advocated to increase clearance and decrease recurrence rates. However, studies investigating the efficacy of adjuvant (...) of the evidence ranged from 'very low' to 'high'. The significantly higher efficacy of low-dose alpha-interferon compared with placebo was based on a single trial, and our confidence in the effect estimates rated as 'low'. Overall, we found no reliable evidence favouring the systemic use of interferon after ablative treatment of AGW.© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly

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2017 Sexually transmitted infections

53. An exploratory, prospective, open-label trial of ingenol mebutate gel 0.05% for the treatment of external anogenital warts. (PubMed)

An exploratory, prospective, open-label trial of ingenol mebutate gel 0.05% for the treatment of external anogenital warts. Anogenital warts (AGW) can cause physical discomfort and decreased quality of life. Recent case reports suggest that ingenol mebutate gel might be an effective treatment of AGW.To explore primarily the safety, and secondarily the efficacy of ingenol mebutate gel 0.05% in patients with AGW.This was an exploratory, open-label, 1-arm trial of ingenol mebutate gel 0.05 (...) % administered up to three times to patients with AGW. Safety was assessed by occurrence and severity of local skin reactions (LSRs) and treatment-related adverse events (AEs). Efficacy was assessed by complete clearance and reduction in AGW count 14 days after last treatment, and recurrence 12 weeks after clearance.Of 41 patients enrolled, 40 received treatment and 26 completed the trial. Patients had a median AGW count of 11.0 and AGW duration of 3.0 years at baseline. All patients experienced transient

2017 Journal of the European Academy of Dermatology and Venereology

54. Small cryotherapy devices for the treatment of skin warts. (PubMed)

Small cryotherapy devices for the treatment of skin warts. Effectiveness of cryotherapy on skin wart models.Two small cryotherapy devices, Wartner and Wortie, were administered for 10″-60″ on tomatoes and potatoes used as skin wart models. Frozen surface and depth were evaluated by standardized photography and computer analysis. Tissue temperature at depths of 0.1-10 mm was assessed by an electronic thermometer during treatment.Cryotherapy induced a transient freezing of the tomato surface

2017 Journal of Dermatological Treatment

55. Pulsed Dye Laser Therapy in the Treatment of Warts: A Review of the Literature. (PubMed)

Pulsed Dye Laser Therapy in the Treatment of Warts: A Review of the Literature. Warts or verrucae vulgaris are common cutaneous infections with currently no definitive curative treatments available.To determine the efficacy of pulsed dye laser (PDL) in the treatment of warts.A literature search was performed using the PubMed and MEDLINE databases. A search using {(Wart[s], verruca or condylomata)} AND [(Pulsed dye laser)] was used. Forty-four articles were identified as relevant (...) been described as very few and rare, the main ones being topical discomfort and erythema.Pulsed dye laser is a safe and effective modality in the treatment of warts that can be applied to most body parts. Cost and availability remain a limitation to the use of PDL; however, this modality can be used when other more traditional and accessible treatments have failed.

2017 Dermatologic Surgery

56. Treatment of Athlete's Plantar Warts Using a Botanical Blend: A Case Report. (PubMed)

Treatment of Athlete's Plantar Warts Using a Botanical Blend: A Case Report. Context • Viral plantar warts, or verruca plantaris, are a benign epithelial tumor caused by various strains of the human papilloma virus (HPV). Current treatments have had mixed degrees of success, are moderately invasive, and are often incompatible with participation in sports. Objective • The study intended to examine the benefits of treating plantar warts with a topical, botanical blend that has had clinical (...) in presentation by the fifth day of treatment. At 1-mo postintervention, or day 90, the epidermal tissue was asymptomatic and devoid of petechiae, malformations, or visible infection. Conclusions • The results of the current case study directly contrast with the drawbacks of commonly accepted, first-line interventions in the treatment of viral plantar warts and, in many respects, demonstrate better efficacy and fewer side effects than the standard of care. The positive results also highlight the necessity

2017 Alternative Therapies in Health & Medicine

57. A Trial of a Botanical Drug Containing East Indian Sandalwood Oil (EISO) for the Treatment of External Genital Warts

A Trial of a Botanical Drug Containing East Indian Sandalwood Oil (EISO) for the Treatment of External Genital Warts A Trial of a Botanical Drug Containing East Indian Sandalwood Oil (EISO) for the Treatment of External Genital Warts - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. A Trial of a Botanical Drug Containing East Indian Sandalwood Oil (EISO) for the Treatment of External Genital Warts The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details

2017 Clinical Trials

58. Intralesional Candidal Antigen Versus Intralesional Zinc Sulphate in Treatment of Cutaneous Warts

Intralesional Candidal Antigen Versus Intralesional Zinc Sulphate in Treatment of Cutaneous Warts Intralesional Candidal Antigen Versus Intralesional Zinc Sulphate in Treatment of Cutaneous Warts - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove (...) one or more studies before adding more. Intralesional Candidal Antigen Versus Intralesional Zinc Sulphate in Treatment of Cutaneous Warts The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03158168 Recruitment Status

2017 Clinical Trials

59. Intralesional Measles, Mumps, Rubella (MMR) Vaccine Versus Cryotherapy in Treatment of Multiple Common and Planter Warts

Intralesional Measles, Mumps, Rubella (MMR) Vaccine Versus Cryotherapy in Treatment of Multiple Common and Planter Warts Intralesional Measles, Mumps, Rubella (MMR) Vaccine Versus Cryotherapy in Treatment of Multiple Common and Planter Warts - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Intralesional Measles, Mumps, Rubella (MMR) Vaccine Versus Cryotherapy in Treatment of Multiple Common and Planter Warts The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details

2017 Clinical Trials

60. Clinical Study : Efficacy and Safety of Three Cryotherapy Devices for Wart Treatment

Clinical Study : Efficacy and Safety of Three Cryotherapy Devices for Wart Treatment Clinical Study : Efficacy and Safety of Three Cryotherapy Devices for Wart Treatment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Clinical Study : Efficacy and Safety of Three Cryotherapy Devices for Wart Treatment The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03129373 Recruitment Status : Completed First Posted : April 26, 2017 Last Update Posted : September 19, 2017 Sponsor: Oystershell NV Information provided

2017 Clinical Trials

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