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Wart Treatment

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21. Combined bivalent human papillomavirus vaccine and Candida antigen versus Candida antigen alone in the treatment of recalcitrant warts. (PubMed)

Combined bivalent human papillomavirus vaccine and Candida antigen versus Candida antigen alone in the treatment of recalcitrant warts. The burden of human papillomavirus (HPV) infection and HPV-associated diseases is consistently growing worldwide. Several combination therapies are being tested nowadays for the treatment of recalcitrant warts, with promising results.To evaluate the potential therapeutic role of combined bivalent HPV vaccine (Cervarix) and Candida antigen versus candida antigen (...) alone in the treatment of multiple recalcitrant warts.Forty patients with recalcitrant warts were enrolled into this study. They were divided into two groups (A and B), each including 20 patients. Patients in the group (A) received intralesional Candida antigen injection alone for five sessions at 2-week intervals. Patients in the group B received combined treatment of bivalent recombinant HPV vaccine and intralesional Candida antigen. Candida antigen was administered as in the group A, while

2019 Journal of cosmetic dermatology Controlled trial quality: uncertain

22. A Randomized double Blind Controlled Study Comparing the Efficacy of Intralesional MMR Vaccine with Normal Saline in the Treatment of Cutaneous Warts. (PubMed)

A Randomized double Blind Controlled Study Comparing the Efficacy of Intralesional MMR Vaccine with Normal Saline in the Treatment of Cutaneous Warts. Recently, with better understanding of the immunology of warts, immunotherapeutic approaches have emerged as an effective treatment option for the management of cutaneous warts. Intralesional immunotherapy with MMR vaccine is one such modality but there are still lack of enough placebo-controlled studies.To evaluate the efficacy of intralesional (...) MMR in patients of extragenital warts in a double-blinded manner using normal saline as control.One hundred patients of extragenital cutaneous warts were randomly allocated into two groups, the interventional (MMR) group and control (normal saline) group. MMR vaccine was injected intralesionally in the patients belonging to interventional group, a similar volume of normal saline (NS) was injected in the control group. The outcome in terms of treatment response, adverse effects, and recurrences

2019 Indian dermatology online journal Controlled trial quality: uncertain

23. Duct tape to treat cutaneous warts

, Holland R, Abbott R. Topical treatments for cutaneous warts. Cochrane database of systematic reviews 2012 Sep 12(9):CD001781 Link: Published: September 2012 Evidence cookie says… Duct tape should not be routinely recommended as wart therapy. There is no compelling evidence that duct tape is more effective than placebo. Clinical scenario Krystal, a 21-year-old office worker saw me recently with common warts on her hand. She mentioned that her mother had suggested that she use duct tape. I recalled (...) that in a recent discussion on the online group GPs Down Under , duct tape had its advocates. What is the evidence? Clinical question What is the effect of applying duct tape as treatment on the recovery of common warts? What does the research evidence say? Step 1: The Cochrane Library The Cochrane Library has a systematic review that is update-to-date to May 2011 on topical treatments for warts, including duct tape [1]. Step 2: TripDatabase & PubMed I conducted a search using the TripDatabase PICO search tool

2017 Morsels of Evidence

24. Duct tape to treat cutaneous warts

, Holland R, Abbott R. Topical treatments for cutaneous warts. Cochrane database of systematic reviews 2012 Sep 12(9):CD001781 Link: Published: September 2012 Evidence cookie says… Duct tape should not be routinely recommended as wart therapy. There is no compelling evidence that duct tape is more effective than placebo. Clinical scenario Krystal, a 21-year-old office worker saw me recently with common warts on her hand. She mentioned that her mother had suggested that she use duct tape. I recalled (...) that in a recent discussion on the online group GPs Down Under , duct tape had its advocates. What is the evidence? Clinical question What is the effect of applying duct tape as treatment on the recovery of common warts? What does the research evidence say? Step 1: The Cochrane Library The Cochrane Library has a systematic review that is update-to-date to May 2011 on topical treatments for warts, including duct tape [1]. Step 2: TripDatabase & PubMed I conducted a search using the TripDatabase PICO search tool

2017 Morsels of Evidence

25. Imiquimod for the Treatment of External Genital Warts in Adults: Clinical and Cost-effectiveness

Imiquimod for the Treatment of External Genital Warts in Adults: Clinical and Cost-effectiveness Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time allowed. Rapid (...) of External Genital Warts in Adults: Clinical and Cost-effectiveness DATE: 07 December 2012 RESEARCH QUESTIONS 1. What is the clinical evidence of the benefits and harms of 5% imiquimod for the treatment of external genital warts? 2. What is the evidence of the cost-effectiveness of 5% imiquimod for the treatment of external genital warts KEY MESSAGE One systematic review, two meta-analyses, three randomized controlled trials, three non- randomized studies, and two economic evaluations were identified

2013 Canadian Agency for Drugs and Technologies in Health - Rapid Review

26. Time-lapse imaging points towards a non-toxic, mainly immune-driven mode of action of ingenol mebutate in the treatment of anogenital warts. (PubMed)

Time-lapse imaging points towards a non-toxic, mainly immune-driven mode of action of ingenol mebutate in the treatment of anogenital warts. Recently, it has been reported that ingenol mebutate (IM) is an effective treatment option for anogenital warts (AGW), inducing fast wart necrosis within 24 hours in vivo. With regard to its mode of action, IM is thought to act both as an inducer of direct cytotoxic effects and immunologic mechanisms. To distinguish whether the wart necrosis is mainly (...) caused by cytotoxic effects, or whether immune mechanisms are leading, we used time-lapse imaging to analyse IM-treated warts ex vivo over 24 hours. Ex vivo IM-treated warts, which have been detached from the immune system, did not show destructive necrosis, pointing towards a primarily immune-driven mode of action of IM in the treatment of AGW.© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

2018 Experimental Dermatology

27. Study of A-101 Topical Solution for the Treatment of Common Warts

Study of A-101 Topical Solution for the Treatment of Common Warts Study of A-101 Topical Solution for the Treatment of Common Warts - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Study of A-101 Topical (...) Solution for the Treatment of Common Warts The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03687372 Recruitment Status : Recruiting First Posted : September 27, 2018 Last Update Posted : March 26, 2019 See Sponsor: Aclaris

2018 Clinical Trials

28. Infrared Bioeffect System for the Treatment of Cutaneous Warts

Infrared Bioeffect System for the Treatment of Cutaneous Warts Infrared Bioeffect System for the Treatment of Cutaneous Warts - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Infrared Bioeffect System (...) for the Treatment of Cutaneous Warts (wart) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03734003 Recruitment Status : Recruiting First Posted : November 7, 2018 Last Update Posted : November 7, 2018 See Sponsor: First Hospital

2018 Clinical Trials

29. Cimetidine: A Safe Treatment Option for Cutaneous Warts in Pediatric Heart Transplant Recipients (PubMed)

Cimetidine: A Safe Treatment Option for Cutaneous Warts in Pediatric Heart Transplant Recipients Abstract:Background andObjectives: Immunosuppressed individuals are at particularly increased risk for human papilloma virus-related infections. The primary objective of our study is to determine if there are any adverse effects associated with high-dose cimetidine treatment. A secondary objective is to report our experience with cimetidine in the treatment of cutaneous warts in pediatric heart (...) resolved with restarting cimetidine therapy. One patient who had only 3 months of cimetidine therapy had immediate relapse after cimetidine was stopped. None of them had significant change in their tacrolimus trough, serum creatinine, and alanine transaminase levels. No adverse events were reported except one patient experienced mild gynecomastia. Conclusion: Cimetidine can be a safe and alternative treatment option for multiple warts in pediatric heart transplant recipients.

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2018 Medical Sciences

30. Cantharone for the Treatment of Perenial Warts

Cantharone for the Treatment of Perenial Warts Cantharone for the Treatment of Perenial Warts - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Cantharone for the Treatment of Perenial Warts The safety (...) Party): Maurice-Andre Recanati, Wayne State University Study Details Study Description Go to Brief Summary: Comparison of trichloroacetic acid versus cantharidine for the treatment of perenial warts. Condition or disease Intervention/treatment Phase Wart, Genital Drug: Cantharidin Drug: Trichloroacetic Acid Phase 4 Detailed Description: Warts are one of the most common sexually transmitted diseases. They are caused by the human papilloma virus (HPV) that causes cervical cancer. Warts can grow

2018 Clinical Trials

31. The Efficacy of Intra-lesional Bleomycin Versus Intra-lesional Purified Protein Derivative in Treatment of Palmoplantar Warts

The Efficacy of Intra-lesional Bleomycin Versus Intra-lesional Purified Protein Derivative in Treatment of Palmoplantar Warts The Efficacy of Intra-lesional Bleomycin Versus Intra-lesional Purified Protein Derivative in Treatment of Palmoplantar Warts - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached (...) the maximum number of saved studies (100). Please remove one or more studies before adding more. The Efficacy of Intra-lesional Bleomycin Versus Intra-lesional Purified Protein Derivative in Treatment of Palmoplantar Warts The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our

2018 Clinical Trials

32. A Study of A-101 Topical Solution for the Treatment of Common Warts

A Study of A-101 Topical Solution for the Treatment of Common Warts A Study of A-101 Topical Solution for the Treatment of Common Warts - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study of A-101 (...) Topical Solution for the Treatment of Common Warts The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03691831 Recruitment Status : Active, not recruiting First Posted : October 2, 2018 Last Update Posted : March 8, 2019 Sponsor: Aclaris Therapeutics, Inc. Information provided by (Responsible Party

2018 Clinical Trials

33. Efficacy and Safety of Topical Cantharidin Treatment for Molluscum Contagiosum and Warts: A Systematic Review. (PubMed)

Efficacy and Safety of Topical Cantharidin Treatment for Molluscum Contagiosum and Warts: A Systematic Review. Topical cantharidin is routinely used for the treatment of molluscum contagiosum and warts. The objective of this systematic review is to assess the efficacy and safety of topical cantharidin treatment for molluscum contagiosum and warts.We performed a systematic review of studies assessing topical cantharidin treatment of molluscum contagiosum or warts. We searched the databases (...) was demonstrated with topical cantharidin alone. Topical cantharidin in combination with podophyllotoxin and salicylic acid demonstrated efficacy for plantar warts (pediatric and adult; clearance rate range 81-100%; four studies had 100% clearance), with the majority clearing after a single treatment. Satisfaction with cantharidin therapy was high, especially in molluscum contagiosum. Pain (7-85.7%), blistering (10-100%), and hyper-/hypopigmentation (1.8-53.3%) were the most commonly occurring adverse effects

2018 American journal of clinical dermatology

34. Intralesional Immunotherapy for the Treatment of Warts: A Network Meta-analysis. (PubMed)

Intralesional Immunotherapy for the Treatment of Warts: A Network Meta-analysis. Without clear evidence, selecting among the existing immunotherapeutic options for warts remains challenging.Through network meta-analyses, we aimed to evaluate the comparative efficacy of different intralesional immunotherapeutic modalities.We included randomized controlled trials comparing intralesional immunotherapeutic modalities to cryotherapy, placebo, or imiquimod. All outcomes were presented as odds ratios

2018 Journal of American Academy of Dermatology

35. Quadrivalent human papilloma virus vaccine for the treatment of multiple warts: a retrospective analysis of 30 patients. (PubMed)

Quadrivalent human papilloma virus vaccine for the treatment of multiple warts: a retrospective analysis of 30 patients. Various therapeutic modalities have been implemented for wart treatment, with limited efficacy. Recently, resistant warts treated using quadrivalent human papilloma virus (HPV) vaccine have been reported, although original articles on the efficacy of quadrivalent HPV vaccine on warts are rare.We performed the present study to evaluate the efficacy of quadrivalent HPV vaccine (...) and location between the three groups divided by treatment response. No severe adverse events after quadrivalent HPV vaccination were noted.The advantage of quadrivalent HPV vaccine in the treatment of warts is that it is more convenient and less painful. HPV vaccine might be a good alternative to conventional destructive methods for incompetent cases such as those including multiple warts, dangerous lesion locations, and uncooperative patients.

2018 Journal of Dermatological Treatment

36. Combination therapy versus monotherapy in the treatment of recalcitrant warts: A clinical and immunological study. (PubMed)

Combination therapy versus monotherapy in the treatment of recalcitrant warts: A clinical and immunological study. Treatment of recalcitrant warts represents a continuing therapeutic challenge. Combination therapies can help improve treatment response, decrease adverse effects, and reduce recurrence.To compare the efficacy, safety and immunological effects of a combined acitretin-intralesional Candida antigen against acitretin alone and Candida antigen alone for intractable warts.Sixty adult (...) patients with intractable warts were included in this study. Patients were subdivided into three groups, each containing 20 patients. Acitretin alone was taken by patients of group I, Candida antigen alone was injected in patients of group II, and group III received a combination of intralesional Candida antigen and acitretin. Serum cytokine levels of IL-10 and IFN-γ were measured before and after therapy in the studied groups.Total resolution of warts was achieved in 8 patients (40%) of the acitretin

2018 Journal of cosmetic dermatology Controlled trial quality: uncertain

37. Cryotherapy vs trichloroacetic acid 90% in treatment of common warts. (PubMed)

Cryotherapy vs trichloroacetic acid 90% in treatment of common warts. Common warts are hyperkeratotic, benign cutaneous growths caused by types 1, 2, and 7 Human papilloma viruses. Different modalities are available to treat warts. Cryotherapy is one of the most common and effective treatments for common warts. Trichloroacetic acid (TCA), in high concentrations, can be used as a therapeutic modality.The aim of this study is to compare the efficacy and safety of cryotherapy using liquid nitrogen (...) (spray method) versus trichloroacetic acid 90% in treatment of common warts.Thirty-five patients with 414 common warts, from the Dermatology outpatient clinic, Assiut University Hospital, were enrolled in this study. We used two techniques for the treatment of common warts. The lesions in each patient were divided into two groups (A and B), group A treated by cryotherapy while group B treated by trichloroacetic acid (TCA) 90%.There was significant decrease in the size of the warts in both groups

2018 Journal of cosmetic dermatology Controlled trial quality: uncertain

38. Efficacy of a bleomycin microneedle patch for the treatment of warts. (PubMed)

Efficacy of a bleomycin microneedle patch for the treatment of warts. Warts are a common skin disease caused by infection of the human papilloma virus. Most treatments involving physical destruction of the infected cells, such as cryotherapy and electrocautery, are limited by intense pain, failure, or recurrences. Our aim was to compare the therapeutic effects of a newly developed bleomycin microneedle patch with cryotherapy in the treatment of warts. Forty-two patients with more than two wart (...) lesions were included in the study. The two treatment modalities were randomly applied to different warts on each patient. Treatment efficacy was assessed using the Physician's Global Assessment (PGA) and the Patient's Global Assessment (PaGA). Mean PGA and PaGA scores were not significantly different between cryotherapy and bleomycin microneedle patch treatment. It was also determined that the mean size of all the warts treated with either modality shrank about equally at weeks 8 and 16 after initial

2018 Drug delivery and translational research Controlled trial quality: uncertain

39. A Phase 2 Controlled Study of SB206, a Topical Nitric Oxide-Releasing Drug for Extragenital Wart Treatment. (PubMed)

A Phase 2 Controlled Study of SB206, a Topical Nitric Oxide-Releasing Drug for Extragenital Wart Treatment. Nitric oxide (NO), a free radical gas, is endogenously produced in human cells. In high concentration, NO neutralizes many disease-causing microbes. The topical investigational drug SB206 releases NO and has the potential to treat skin diseases caused by viruses. Genital warts (condyloma acuminata) are primarily caused by human papillomavirus (HPV) types 6 and 11. Available treatments (...) have low tolerability and efficacy rates and are inconvenient for the patient. Genital warts can recur if HPV is incompletely eradicated during treatment.Topical SB206 (berdazimer sodium plus carboxymethyl cellulose hydrogel) was assessed for tolerability, safety, and efficacy for up to12 weeks in patients with external genital and/or perianal warts (EGW/PAW) in a phase 2, double-blind, randomized, dose-escalation study.Patients (N=108) were randomly assigned to SB206 or vehicle in a 3:1 ratio

2018 Journal of drugs in dermatology : JDD Controlled trial quality: uncertain

40. Comparison of clinical efficacy and safety of thermotherapy versus cryotherapy in treatment of skin warts: A randomized controlled trial. (PubMed)

Comparison of clinical efficacy and safety of thermotherapy versus cryotherapy in treatment of skin warts: A randomized controlled trial. The effect of thermotherapy in the treatment of skin warts in comparison to cryotherapy, as the standard conventional method, has remained uncertain. This study aimed to assess the clinical efficacy and safety of thermotherapy and cryotherapy in removing skin warts. This randomized controlled trial was conducted on 52 patients aged 18 years and over with ≤ 10 (...) skin warts. The participants were randomly assigned into two groups to receive cryotherapy (every 2 to 3 weeks up to six sessions if required) or thermotherapy (one session). The patients in both groups were followed every 2 to 3 weeks for the first three months, and then three months after the last treatment session. The clearance rate was 79.2% in the thermotherapy group and 58.3% in the cryotherapy group with no significant difference (p = 0.212). The rate of scarring in the thermotherapy group

2018 Dermatologic therapy Controlled trial quality: uncertain

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