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Wart Treatment

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1. Topical Cantharidin/ Salicylic Acid/ Podophyllin for the Treatment of Warts: Clinical Effectiveness and Guidelines

Topical Cantharidin/ Salicylic Acid/ Podophyllin for the Treatment of Warts: Clinical Effectiveness and Guidelines Topical Cantharidin/ Salicylic Acid/ Podophyllin for the Treatment of Warts: Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Topical Cantharidin/ Salicylic Acid/ Podophyllin for the Treatment of Warts: Clinical Effectiveness and Guidelines Topical Cantharidin/ Salicylic Acid/ Podophyllin for the Treatment of Warts: Clinical Effectiveness (...) and Guidelines Last updated: January 21, 2019 Project Number: RA1006-000 Product Line: Research Type: Drug Report Type: Reference List Result type: Report Question What is the comparative clinical effectiveness of topical cantharidin/salicylic acid/podophyllin versus other topical treatments for warts? What are the evidence-based guidelines for the topical treatment of warts? Key Message One non-randomized study and two evidence-based guidelines were identified regarding topical cantharidin/ salicylic acid

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

2. Oral cimetidine as the treatment of common warts

Oral cimetidine as the treatment of common warts Oral cimetidine as the treatment of common warts – Morsels of Evidence \t\t\t\r\n\t\t\t \t\t\t\r\n\t\t\t Share this: Like this: Like Loading... ","author":{"@type":"Person","name":"Michael Tam"},"image":["https:\/\/evidencebasedmedicine.com.au\/wp-content\/uploads\/2019\/01\/MO-DecJan2019cover.png"]} Toggle search form Toggle navigation Evidence-based medicine for general practitioners Jan 07 2019 Oral cimetidine as the treatment of common warts (...) By in , 7 January 2019 Journal reference: Yilmaz E, Alpsoy E, Basaran E. Cimetidine therapy for warts: a placebo-controlled, double-blind study. J Am Acad Dermatol 1996 Jun;34(6):1005-7 Link: Published: June 1996 Evidence cookie says… The limited research evidence does not support the use of oral cimetidine as the treatment of common warts anecdotal evidence of major benefits are not seen in blinded randomised trials although cimetidine is often seen as benign, side-effects were reported in a fifth

2019 Morsels of Evidence

3. Imiquimod for the Treatment of Genital Warts: A Review of Clinical Effectiveness and Cost-Effectiveness

Imiquimod for the Treatment of Genital Warts: A Review of Clinical Effectiveness and Cost-Effectiveness Imiquimod for the Treatment of Genital Warts: A Review of Clinical Effectiveness and Cost-Effectiveness | CADTH.ca Find the information you need Imiquimod for the Treatment of Genital Warts: A Review of Clinical Effectiveness and Cost-Effectiveness Imiquimod for the Treatment of Genital Warts: A Review of Clinical Effectiveness and Cost-Effectiveness Published on: September 25, 2017 Project (...) Number: RC0930-000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of imiquimod for the treatment of genital warts? What is the cost-effectiveness of imiquimod for the treatment of genital warts? Key Message Evidence from systematic reviews with low quality included studies suggests that overall for patients with anogenital warts (AGW) compared to placebo, treatment with imiquimod (IMQ) is associated

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

4. Genital warts

Genital warts Genital warts - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Genital warts Last reviewed: February 2019 Last updated: February 2019 Summary Very common STI. Caused by human papillomavirus (HPV) infection, most commonly HPV types 6 and 11. Peak incidence of genital HPV infection occurs in 16- to 25-year-olds. Diagnosis is made based on clinical presentation. Generally has a benign course (...) and is not often associated with oncogenic potential. Treatment can be challenging, as there is no cure and recurrences are common. Definition Genital warts are the most prevalent form of viral genital mucosal lesions and are caused by infection with several types of human papillomavirus (HPV). Mansur CP. Human papillomaviruses. In: Tyring SK, ed. Mucocutaneous manifestations of viral diseases. New York, NY: Marcel Dekker; 2002:247-94. The infection manifests as verrucous fleshy papules that may coalesce

2019 BMJ Best Practice

5. Green tea leaf extract (Catephen) - cutaneous treatment of external genital and perianal warts (condylomata acuminata

Green tea leaf extract (Catephen) - cutaneous treatment of external genital and perianal warts (condylomata acuminata AWMSG SECRETARIAT ASSESSMENT REPORT Green tea leaf extract (Catephen ® ) 10% Ointment Reference number: 2739 FULL SUBMISSION This report has been prepared by the All Wales Therapeutics and Toxicology Centre (AWTTC), in collaboration with the Centre for Health Economics and Medicines Evaluation, Bangor University. Please direct any queries to AWTTC: All Wales Therapeutics (...) This assessment report is based on evidence submitted by Kora Healthcare 1 . 1.0 PRODUCT DETAILS Licensed indication under consideration Green tea leaf extract (Catephen ® ) for the cutaneous treatment of external genital and perianal warts (condylomata acuminata) in immunocompetent patients from the age of 18 years. Dosing Up to 250 mg Catephen ® ointment as total single dose, corresponding to about 0.5 cm of ointment strand to be applied three times per day to all external genital and perianal warts (750 mg

2016 All Wales Medicines Strategy Group

6. Common warts

Common warts Common warts - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Common warts Last reviewed: February 2019 Last updated: January 2018 Summary Common warts, also known as verrucae vulgaris, are caused by HPV infection and affect most people during their lifetimes. They are most common in children and young adults. Common warts should be distinguished from serious conditions that mimic them, such as squamous (...) cell carcinoma, especially in immunocompromised patients. The goals of treatment are to destroy the lesion, induce cytotoxicity against infected cells, and promote antiviral immunoresponsiveness to prevent recurrence. Best outcomes are achieved with a combination of destructive and immunosensitising approaches. Most common warts in healthy people resolve spontaneously. Clearance rates in children from time of diagnosis to clearance are 23% at 2 months, 30% at 3 months, 65% to 78% at 2 years, and 90

2018 BMJ Best Practice

7. Genital warts

Genital warts Genital warts - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Genital warts Last reviewed: February 2019 Last updated: February 2019 Summary Very common STI. Caused by human papillomavirus (HPV) infection, most commonly HPV types 6 and 11. Peak incidence of genital HPV infection occurs in 16- to 25-year-olds. Diagnosis is made based on clinical presentation. Generally has a benign course (...) and is not often associated with oncogenic potential. Treatment can be challenging, as there is no cure and recurrences are common. Definition Genital warts are the most prevalent form of viral genital mucosal lesions and are caused by infection with several types of human papillomavirus (HPV). Mansur CP. Human papillomaviruses. In: Tyring SK, ed. Mucocutaneous manifestations of viral diseases. New York, NY: Marcel Dekker; 2002:247-94. The infection manifests as verrucous fleshy papules that may coalesce

2018 BMJ Best Practice

8. Green tea leaf extract (Veregen) - an aggressive topical treatment for anogenital warts

Green tea leaf extract (Veregen) - an aggressive topical treatment for anogenital warts Prescrire IN ENGLISH - Spotlight ''In the April issue of Prescrire International: Green tea leaf extract (Veregen°) - an aggressive topical treatment for anogenital warts'', 1 April 2015 {1} {1} {1} | | > > > In the April issue of Prescrire International: Green tea leaf extract (Veregen°) - an aggressive topical treatment for anogenital warts Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 (...) most recent :  |   |   |   |   |   |   |   |   |  Spotlight In the April issue of Prescrire International: Green tea leaf extract (Veregen°) - an aggressive topical treatment for anogenital warts FREE DOWNLOAD In this sample page from the New Products section: while drugs obtained from plants have the reputation of being innocuous, they sometimes provoke serious adverse effects. Full text available for free download. Summary

2015 Prescrire

9. Evaluation of combined treatment with long-pulsed neodymium-doped yttrium aluminum garnet laser and potassium hydroxide for the treatment of recalcitrant wart: a prospective comparative study. (Abstract)

Evaluation of combined treatment with long-pulsed neodymium-doped yttrium aluminum garnet laser and potassium hydroxide for the treatment of recalcitrant wart: a prospective comparative study. Background: Lasers have been used for verruca treatment in recent years with successful results in some types. In addition, peeling processes have been used to enhance penetration in some studies. Objectives: This study aimed to evaluate combined treatment with LP Nd:YAG laser and KoH for the treatment (...) of recalcitrant wart. Methods: This study included 132 lesions from 38 patients. Long-pulsed (LP) Nd:YAG laser was applied to 66 lesions with daily 10% KOH application at night, and the remaining 66 lesions underwent LP Nd:YAG laser therapy only. Results: Both groups showed statistically significant regressions in the size of the lesions at the end of the fifth session compared with those present at the onset of therapy (p < .05). Also, complete clearance of the lesions was noticed after 2.2 sessions

2019 Journal of Dermatological Treatment

10. Successful Treatment of Multiple Common Warts With Intralesional Ozone. (Abstract)

Successful Treatment of Multiple Common Warts With Intralesional Ozone. Although there are multiple treatments for warts, wart management remains a challenge. Ozone therapy is an emerging treatment for infectious and noninfectious dermatological diseases.To assess intralesional ozone gas safety and efficacy in multiple warts management.Seventy-four adult patients with multiple common warts were included in this study. They were randomly assigned into 2 groups: first group comprised 44 patients (...) treated with intralesional ozone gas, and the second group comprised 30 patients who received intralesional saline injection. In both groups, warts in all patients were directly injected weekly until complete clearance occurred or for a maximum of 10 treatment sessions. The subjects were followed for 6 months to record any recurrences.In the ozone group, 25 patients (56.8%) had a complete response with an excellent cosmetic outcome, 15 patients (34.1%) showed a partial response, and 4 patients (9.1

2019 Dermatologic Surgery

11. Intralesional injection of vitamin D3 versus zinc sulfate 2% in treatment of plantar warts: a comparative study. (Abstract)

Intralesional injection of vitamin D3 versus zinc sulfate 2% in treatment of plantar warts: a comparative study. Background: Plantar warts are common skin lesions caused by the human papilloma virus. It is characterized by the presence of a horny ring of hyperkeratosis surrounding the wart, making its elimination a therapeutic challenge. Several destructive agents are available for treatment with variable success. Intralesional vitamin D3 has been reported as a successful treatment of warts (...) . Intralesional zinc sulfate has been found to be another successful therapeutic modality for wart elimination. Objective: To compare the efficacy and safety of intralesional vit. D3 versus zinc sulfate in treatment of plantar warts. Patients and methods: Forty patients were included in the study. Patients were randomly assigned to either vit. D3 group or zinc group. In vit. D3 group, patients received intralesional injection of 0.3 ml vitamin D3 (100,000 IU (2.5 mg/ml)), while zinc group patients received

2019 Journal of Dermatological Treatment Controlled trial quality: uncertain

12. Ungual warts: comparison of treatment with intralesional bleomycin and electroporation in terms of efficacy and safety. (Abstract)

Ungual warts: comparison of treatment with intralesional bleomycin and electroporation in terms of efficacy and safety. Ungual warts are considered the most common benign nail tumour, and they are caused by the human papillomavirus. Despite the numerous treatments reported in the medical literature, ungual warts are considered frustrating, with high relapse rates and a potential risk of nail dystrophy. Bleomycin is a therapeutic option showing a good safety profile and high cure rates.To (...) evaluate the efficacy of electrochemotherapy using intralesional bleomycin for the treatment of ungual warts in comparison with intralesional bleomycin alone and describe the side-effects related to the use of both techniques.This was a prospective, randomized, double-blind, controlled clinical trial. Forty-four 18- to 60-year-old female and male patients with ungual warts of only one finger were included. The patients were divided into two treatment groups: GA - intralesional bleomycin; and GB

2019 Journal of the European Academy of Dermatology and Venereology Controlled trial quality: uncertain

13. Combined bivalent human papillomavirus vaccine and Candida antigen versus Candida antigen alone in the treatment of recalcitrant warts. (Abstract)

Combined bivalent human papillomavirus vaccine and Candida antigen versus Candida antigen alone in the treatment of recalcitrant warts. The burden of human papillomavirus (HPV) infection and HPV-associated diseases is consistently growing worldwide. Several combination therapies are being tested nowadays for the treatment of recalcitrant warts, with promising results.To evaluate the potential therapeutic role of combined bivalent HPV vaccine (Cervarix) and Candida antigen versus candida antigen (...) alone in the treatment of multiple recalcitrant warts.Forty patients with recalcitrant warts were enrolled into this study. They were divided into two groups (A and B), each including 20 patients. Patients in the group (A) received intralesional Candida antigen injection alone for five sessions at 2-week intervals. Patients in the group B received combined treatment of bivalent recombinant HPV vaccine and intralesional Candida antigen. Candida antigen was administered as in the group A, while

2019 Journal of cosmetic dermatology Controlled trial quality: uncertain

14. A Randomized double Blind Controlled Study Comparing the Efficacy of Intralesional MMR Vaccine with Normal Saline in the Treatment of Cutaneous Warts. (Abstract)

A Randomized double Blind Controlled Study Comparing the Efficacy of Intralesional MMR Vaccine with Normal Saline in the Treatment of Cutaneous Warts. Recently, with better understanding of the immunology of warts, immunotherapeutic approaches have emerged as an effective treatment option for the management of cutaneous warts. Intralesional immunotherapy with MMR vaccine is one such modality but there are still lack of enough placebo-controlled studies.To evaluate the efficacy of intralesional (...) MMR in patients of extragenital warts in a double-blinded manner using normal saline as control.One hundred patients of extragenital cutaneous warts were randomly allocated into two groups, the interventional (MMR) group and control (normal saline) group. MMR vaccine was injected intralesionally in the patients belonging to interventional group, a similar volume of normal saline (NS) was injected in the control group. The outcome in terms of treatment response, adverse effects, and recurrences

2019 Indian dermatology online journal Controlled trial quality: uncertain

15. Intralesional vitamin D3 versus Candida antigen immunotherapy in the treatment of multiple recalcitrant plantar warts: A comparative case-control study. (Abstract)

Intralesional vitamin D3 versus Candida antigen immunotherapy in the treatment of multiple recalcitrant plantar warts: A comparative case-control study. Intralesional immunotherapy is one of the therapeutic tools of warts. Intralesional Candida antigen was reported as successful treatment of warts. Topical and intralesional vitamin D have been used recently for wart treatment. We aim to evaluate the efficacy and safety of intralesional injection of vitamin D3 in treatment of multiple (...) recalcitrant plantar warts in comparison with intralesional Candida antigen. Sixty patients were divided into three groups: Group I received intralesional vitamin D3, Group II intralesional Candida antigen, and Group III intralesional saline (control group). Injection was done every 3 weeks until clearance of warts or a maximum of three treatments. There was a statistically significant more reduction of warts numbers after treatment in Group I than in the other groups (p < .05). Group I showed better

2019 Dermatologic therapy Controlled trial quality: uncertain

16. Intralesional versus intramuscular bivalent human papillomavirus vaccine in the treatment of recalcitrant common warts. (Abstract)

Intralesional versus intramuscular bivalent human papillomavirus vaccine in the treatment of recalcitrant common warts. Despite the availability of different therapeutic modalities, treatment of recalcitrant common warts is still challenging. Cervarix, a recombinant bivalent human papillomavirus (HPV) vaccine, has shown promising efficacy in the treatment of warts.To evaluate the beneficial effects and tolerability of intramuscular versus intralesional bivalent HPV vaccine in the treatment (...) of recalcitrant common warts.The study included 44 adult patients with multiple recalcitrant common warts; 22 patients were injected with intramuscular bivalent HPV vaccine at 0, 1, and 6 months or until complete clearance of warts and the other 22 patients were intralesionally injected with 0.1 to 0.3 ml of bivalent HPV vaccine into the largest wart at 2-week intervals until complete clearance or for a maximum of six sessions.Complete clearance of warts was observed in 18 patients (81.8

2019 Journal of American Academy of Dermatology

17. Successful treatment of recalcitrant plantar warts by carbon dioxide laser with a computerized scanner. (Abstract)

Successful treatment of recalcitrant plantar warts by carbon dioxide laser with a computerized scanner. Warts are benign neoplasms of the skin and mucosa caused by human papillomavirus (HPV) infection.1 The most common treatments for wart are topical application of salicylic acid and cryotherapy. Other modalities include chemical agents, contact sensitizing agents and surgical excision.2 Laser modalities, including carbon dioxide (CO2 ), pulsed dye and neodymium-doped: yttrium-aluminum-garnet (...) lasers, have also been used to treat recalcitrant plantar warts.© 2019 British Association of Dermatologists.

2019 British Journal of Dermatology

18. Efficacy of bleomycin application on periungual warts after treatment with ablative carbon dioxide fractional laser: a pilot study. (Abstract)

Efficacy of bleomycin application on periungual warts after treatment with ablative carbon dioxide fractional laser: a pilot study. Treating periungual warts is a therapeutic challenge. Treatments are often ineffective and may cause complications including permanent nail changes, pain, and scaring. Translesional bleomycin delivery via the multipuncture technique is now reported.To investigate the efficacy and safety of bleomycin solution (1 U/mL) after ablative fractional carbon dioxide (CO2 (...) ) laser for treating periungual warts.Warts were treated with ablative CO2 fractional laser, after which bleomycin was applied. Patients were treated every 2 weeks until the lesions disappeared. Treatment was discontinued if adverse events occurred or the patient wanted to stop.Seventeen patients (11 women, mean age 16.23 years) with a total of 38 warts were enrolled from May 2017 to Aug 2018. Twenty-six lesions (68.4%) achieved complete clearance; three (7.8%) had excellent partial response (>75

2019 Journal of Dermatological Treatment

19. Imiquimod for the Treatment of External Genital Warts in Adults: Clinical and Cost-effectiveness

Imiquimod for the Treatment of External Genital Warts in Adults: Clinical and Cost-effectiveness Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time allowed. Rapid (...) of External Genital Warts in Adults: Clinical and Cost-effectiveness DATE: 07 December 2012 RESEARCH QUESTIONS 1. What is the clinical evidence of the benefits and harms of 5% imiquimod for the treatment of external genital warts? 2. What is the evidence of the cost-effectiveness of 5% imiquimod for the treatment of external genital warts KEY MESSAGE One systematic review, two meta-analyses, three randomized controlled trials, three non- randomized studies, and two economic evaluations were identified

2013 Canadian Agency for Drugs and Technologies in Health - Rapid Review

20. External genital and perianal warts: green tea (Camellia sinensis) leaf extract 10% ointment

summaries of product characteristics (SPCs), British national formulary (BNF) or the MHRA or NICE websites for up-to-date information. Summary Green tea (Camellia sinensis) leaf extract 10% ointment (Catephen) is a self-administered topical treatment for external genital and perianal warts. In 2 randomised controlled trials (RCTs) involving a total of 1005 adults, green tea leaf extract 10% ointment was 2-fold more effective than vehicle (placebo) ointment in terms of complete clearance of all baseline (...) and new warts over a maximum treatment duration of 16 weeks. Most reported adverse events were local skin reactions, and were mild or moderate in severity. There are no published comparisons with other active treatments for genital and perianal warts. Regulatory status Regulatory status: Catephen 10% ointment was launched in the UK in November 2015. © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 1 of 20Effectiv

2015 National Institute for Health and Clinical Excellence - Advice

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