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Wart Immune Therapy

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101. Gynaecological Cancers: a Handbook for Aboriginal and Torres Strait Islander Health Workers and Health Practitioners

Investigating symptoms 12 Chapter 3: If it’s cancer – what next? 17 Explaining test results 17 Overview of treatments for gynaecological cancers 18 Complementary therapies and bush medicine 19 Multidisciplinary care 21 Chapter 4: Cervical cancer 25 What causes cervical cancer? 25 Reducing the risk of cervical cancer 26 National HPV Vaccination Program 26 Cervical Screening Test 27 Why has the Cervical Screening Test changed? 27 Why does screening start at 25? 27 What does the Cervical Screening Test involve (...) , radiotherapy and chemotherapy. • Complementary therapies, including some bush medicine, can be used alongside conventional treatments, but it is important to check with the treating doctor to make sure they will not interfere with treatment. • Providing information about treatments will enable a woman to make an informed choice about her treatment. • It is important to respect a woman’s choice about her treatment. Explaining test results When a woman is diagnosed with gynaecological cancer, test results

2018 Cancer Australia

102. Evaluation and Management of the Child and Adult With Fontan Circulation: A Scientific Statement From the American Heart Association Full Text available with Trip Pro

providers are ill-prepared to tackle these challenges, as well as specific needs such as contraception and pregnancy in female patients. The role of therapies such as cardiovascular drugs to prevent and treat complications, heart transplantation, and mechanical circulatory support remains undetermined. There is a clear need for consensus on how best to follow up patients with Fontan circulation and to treat their complications. This American Heart Association statement summarizes the current state (...) , ventricular, or dual chamber) are not reported or analyzed separately. Pacing without atrioventricular synchrony and rate optimization and pacing only the ventricle can be expected to negatively affect hemodynamic status in the patient with a single ventricle. Therapies for atrial tachycardia include antiarrhythmic medications, catheter ablation, atrial antibradycardia and antitachycardia pacing, and Fontan conversion with arrhythmia surgery. Patients with Fontan circulation presenting with arrhythmias

2019 American Heart Association

103. Canadian Urological Association guideline on the care of the normal foreskin and neonatal circumcision in Canadian infants (Full Version)

Department of Surgery (Urology), McMaster University, Hamilton, ON; 4 Department of Urology, Dalhousie University, Halifax, NS; Canada physicians who provide neonatal circumcision services, and pediatric urologists and general surgeons. The current guide- line is written with the purpose of being applicable to the Canadian population and healthcare system. The evidence presented is classified according to the Oxford system of evidence-based medicine. 7 The current guideline attempts to answer (...) the following questions: 1. Do the potential benefits of neonatal circumcision justify performing universal neonatal circumcision in Canada? 2. For an individual patient and parent, what are the benefits and risks of a neonatal circumcision and how reliable and applicable is the evidence currently available? 3. What should be the prescribed routine foreskin care in infants, indications for medically indicated circum- cision, and management of physiological phimosis? Methods Systematic literature searches

2018 Canadian Urological Association

104. Immune Response and Safety Study of Human Papillomavirus (HPV) Vaccine in HIV-infected Pre-adolescent in Kenya

Immune Response and Safety Study of Human Papillomavirus (HPV) Vaccine in HIV-infected Pre-adolescent in Kenya A Cohort Study to Assess Sustained Immunogenicity to qHPV Vaccine Among HIV-infected Girls and Boys Age 9-14 Years - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) : October 5, 2011 Last Update Posted : September 7, 2016 Sponsor: Kenyatta National Hospital Collaborators: University of Washington Merck Sharp & Dohme Corp. Kenya Medical Research Institute Information provided by (Responsible Party): Nelly R. Mugo, Kenya Medical Research Institute Study Details Study Description Go to Brief Summary: The purpose of this study is to determine sustained immunogenicity of the quadrivalent vaccine 'Gardasil', 48 months after initial vaccination, among HIV-1 infected boys

2011 Clinical Trials

105. Guidelines for the Management of Genital, Anal and Throat HPV Infection in New Zealand

. The PAB has representation from patients and medical and nursing disciplines involved in the management of people with anogenital HPV and/or genital warts. A process was undertaken to evaluate contemporary international literature and develop best practice regarding the diagnosis, treatment and evaluation of patients with HPV infection/genital warts and their sex partners, in Australasia. The recommendations are based on strong evidence in the literature or reasonable suppositions and opinions (...) of the warts, the age of the patient and whether the patient is pregnant. • All treatments have significant failure and relapse rates. • People with a small number of low volume warts, irrespective of type can be treated with either ablative therapy or topical treatment. Podophyllotoxin for 4 weeks or imiquimod for 16 weeks are suitable home treatments for patients. The patient should be given a demonstration on lesion finding, treatment application and advice about discomfort and local skin reactions from

2017 New Zealand Sexual Health Society

106. Sexually Transmitted Infections

or valaciclovir therapy can be used to treat symptomatic recurrences. From 36 weeks, treatment can be considered to reduce the chance of a recurrence at term and hence the need for caesarean section. Effects on the neonate have not been fully determined. However, aciclovir (and to a lesser extent valaciclovir, which is a pro-drug of aciclovir) has been widely used in pregnancy without reported adverse consequences. See full text for further information. ** SEM – skin, eye and/or mouth lesions only. YES (...) %, oropharynx 26%). • Although genital warts and genital tract cancers are declining, HPV-associated head and neck cancers and anal cancers are increasing – especially in men. Does natural infection induce protective immunity? • Not always. Current evidence suggests that overall naturally acquired immunity is unlikely to be effective because of the ability of the virus to evade the immune system. Previous infection does not necessarily create long term immune memory so does not prevent future re-infection

2017 New Zealand Sexual Health Society

107. Guidelines for the Management of Genital Herpes in New Zealand

Neurotoxicity (lethargy, confusion, hallucinations and involuntary movements) has been reported in those with renal impairment. Topical antiviral therapy Topical aciclovir creams are less effective than oral aciclovir. 34 Hence, use of topical treatment is not recommended. Topical antiviral creams are available over the counter, but are no longer subsidised on the pharmaceutical schedule. Newer topical agents such as immune modulators are currently in clinical trials. Other therapies Evidence for other (...) is generally more severe and/or more prolonged, treatment should always be offered regardless of time of symptom onset. Valaciclovir prescriptions do not require specialist authorisation and the medication is available through any pharmacy. Patients are often very unwell and therapy should be initiated regardless of how long the lesions have been present and before virological confirmation. This is based on evidence that the virus is shed from the infected area for a median of 11 days, with systemic

2017 New Zealand Sexual Health Society

108. Anal Squamous Cell Cancers

) David B. Stewart, M.D. 1 • Wolfgang B. Gaertner, M.D., M.Sc. 2 • Sean C. Glasgow, M.D. 3 Daniel O. Herzig, M.D. 4 • Daniel Feingold, M.D. 5 • Scott R. Steele, M.D. 5 Prepared on Behalf of the Clinical Practice Guidelines Committee of the American Society of Colon and Rectal Surgeons 1 Department of Surgery, University of Arizona, Tucson, Arizona 2 Division of Colorectal Surgery, University of Minnesota, Minneapolis, Minnesota 3 Division of Colorectal Surgery, Washington University School of Medicine (...) curable at the time of diagnosis and treatment. The multiple risk factors associated with developing squamous cancers of the anus are well documented and can be grouped into the 2 broad categories of HPV and immunosuppression, although there is also an association between these categories as well. Among the HPV-related risk factors include lifetime number of sexual partners, 9 a history of previous sexually transmitted diseases of any kind, 10 a history of anogenital warts, 11 anoreceptive

2018 American Society of Colon and Rectal Surgeons

109. Lichen Planus

. Department of Dermatology and Venereology, Aristotle University of Thessaloniki Medical School, Greece 2. Department of Dermatology and Allergology, University of Szeged, Hungary 3. Department of Dermatology and Venereology, University Hospital Center and School of Medicine Zagreb, Croatia 4. Department of Dermatology, Medical University of Graz, Austria 5. Department of Dermatology, Nottingham University Hospital, Nottingham, UK 6. Charité - Universitätsmedizin Berlin, Corporate member of Freie (...) . Department of Dermatology, Hospital del Mar, Barcelona, Spain 12. Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK. 13. Department of Dermatology, Erasmus MC, Rotterdam, The Netherlands Corresponding author: Professor Dimitrios Ioannides Head, 1st Department of Dermatology and Venereology, Aristotle University Medical School, Hospital of Skin and Venereal Diseases - Hippokration General Hospital Thesssaloniki, Greece Tel.: (+30) 2310-992262 Fax: (+30 )2310-992221 Email: dem

2018 European Dermatology Forum

110. Atopic Eczema

, phototherapy and antipruritic therapy, whereas the second part covers 8 antimicrobial therapy, systemic treatment, allergen specific immunotherapy, complementary 9 medicine, psychosomatic counselling and educational interventions. 10 Management of AE must consider the individual clinical variability of the disease, highly 11 standardized treatment rules are not recommended. Basic therapy is focused on treatment of 12 disturbed barrier function by hydrating and lubricating topical treatment, besides further (...) includes UV irradiation, preferably with UVB 311 nm or UVA1. Pruritus is 19 targeted with the majority of the recommended therapies, but some patients may need additional 20 antipruritic therapy. Antimicrobial therapy, systemic anti-inflammatory treatment, 21 immunotherapy, complementary medicine and educational intervention will be addressed in part 22 II of the guideline. 23 24 Key words: Atopic eczema, atopic dermatitis, pruritus, immunomodulation, emollients 25 26 EDF Guideline AE part I and II

2018 European Dermatology Forum

111. A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2018 Update by the Infectious Diseases Society of America and the American Society for Microbiology Full Text available with Trip Pro

, Connecticut Search for other works by this author on: Karen C Carroll Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland Search for other works by this author on: Kimberle C Chapin Department of Pathology, Rhode Island Hospital, Providence Search for other works by this author on: Peter H Gilligan Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill Search for other works by this author on: Mark D Gonzalez Department of Pathology (...) , Children’s Healthcare of Atlanta, Georgia Search for other works by this author on: Robert C Jerris Department of Pathology, Children’s Healthcare of Atlanta, Georgia Search for other works by this author on: Sue C Kehl Medical College of Wisconsin, Milwaukee Search for other works by this author on: Robin Patel Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota Search for other works by this author on: Bobbi S Pritt Division of Clinical

2018 Infectious Diseases Society of America

112. HTA of extending the HPV vaccination to boys

Immunoassay EMA European Medicines Agency ENT Ear, Nose And Throat EPAR European Public Assessment Report EQ-5D-5L Euroqol 5-Dimension, 5-Level Instrument EU European Union EVG Early Vaccination Group FDA Food And Drugs Authority FIGO Féderation Internationale De Gynecologie Et d’Obstetrique (International Federation Of Obstetrics And Gynaecology) FUTURE Females United To Unilaterally Reduce Endo/Ectocervical Disease GACVS Global Advisory Committee On Vaccine Safety GBS Guillain-Barré Syndrome GMT (...) Authority HPSC Health Protection Surveillance Centre HPV Human Papillomavirus hrHPV High-Risk Human Papillomavirus HSE Health Service Executive HSIL High-Grade Squamous Intraepithelial Lesion HTA Health Technology Assessment IARC International Agency For Research On Cancer ICD International Classification Of Diseases ICER Incremental Cost-Effectiveness Ratio ICO Institut Català D'oncologia (Catalan Institute Of Oncology) IMRT Intensity Modulated Radiation Therapy IPHA Irish Pharmaceutical Healthcare

2018 Health Information and Quality Authority

113. HPV Vaccination in Men: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines

Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of HPV vaccination for males using the quadrivalent vaccine or 9-valent vaccine for preventing HPV infection and HPV-related genital warts and cancers of the penis, anus, or oropharynx in men? What is the cost-effectiveness of HPV vaccination for males using the quadrivalent vaccine or 9-valent vaccine for preventing HPV infection and HPV-related genital warts (...) and cancers of the penis, anus, or oropharynx in men? What are the evidence-based guidelines regarding HPV vaccination in men? Key Message A growing body of evidence supports the immunization of boys and young men (up to age 26), particularly with the approval of a 9V vaccine that expands the HPV types covered and additional types of cancers impacted. Recent national guidelines from Canada and the US now recommend including boys and young men in HPV immunization programs, as well as people who

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

114. Responding to children and adolescents who have been sexually abused

from the United States Govern- ment’s President’s Emergency Plan For AIDS Relief (PEPFAR); and the United Nations Development Programme (UNDP)/United Nations Population Fund (UNFPA)/United Nations Children’s Fund (UNICEF)/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP).vi Acronyms and abbreviations ARV antiretroviral drug CBT cognitive behavioural therapy CEDAW Convention on the Elimination of all Forms of Discrimination against Women CDC (...) ) should be provided for HIV PEP , following initial risk assessment. Low Strong R3 A triple-therapy regimen (i.e. with three drugs) of ARVs is preferred but a two-drug regimen is also effective. Very low Conditional R4 Adherence counselling should be an important element in the provision of HIV PEP to survivors of sexual assault or rape. Very low Strong D. PREGNANCY PREVENTION AND MANAGEMENT AMONG GIRLS WHO HAVE BEEN SEXUALLY ABUSED QUALITY OF EVIDENCE STRENGTH OF RECOMMENDATION R5 Offer emergency

2017 World Health Organisation Guidelines

115. WHO guideline on syphilis screening and treatment for pregnant women

acquired immune deficiency syndrome AMR antimicrobial resistance CI confidence interval DOI declaration of interests FTA-ABS fluorescent treponemal antibody absorbed GDG Guideline Development Group GRADE Grading of Recommendations Assessment, Development and Evaluation GUD genital ulcer disease HIV human immunodeficiency virus HPV human papillomavirus HSV herpes simplex virus HSV-2 herpes simplex virus type 2 MSH Management Sciences for Health MSM men who have sex with men PICO population, intervention (...) are associated with the highest HIV transmission risk; in addition to curable ulcer-causing STIs (e.g. syphilis and chancroid), highly prevalent HSV-2 infections substantially increase that risk (9). Non-ulcerative STIs, such as gonorrhoea, chlamydia and trichomoniasis, have been shown to increase HIV transmission through genital shedding of HIV (10). Treating STIs with the right medicines at the right time is necessary to reduce HIV transmission and improve sexual and reproductive health (11). Efforts

2017 World Health Organisation Guidelines

116. Management of Uterine Fibroids

., M.B.A. Cook Incorporated Bloomington, IN Tina Groat, M.D., M.B.A., FACOG United Healthcare Plano, TX Phyllis Leppert, M.D., Ph.D. Duke University Medical Center Durham, NC Mary Ann Lumsden, M.D., FRCOG* University of Glasgow Glasgow, Scotland, UK Wanda K. Nicholson, M.D., M.P.H., M.B.A. University of North Carolina Chapel Hill, NC v Allison O’Neill, Ph.D., M.A. Food and Drug Administration Silver Spring, MD Christopher Ronk, Sc.D. Food and Drug Administration Silver Spring, MD Ann Shortliffe, R.N (...) to avoid menstrual periods, nonsteroidal anti-inflammatory agents to improve bleeding or dysmenorrhea, and agents such as stool softeners to prevent constipation from bulky fibroids. However, we identified RCTs for five types of clinically less common medications: GnRH agonists, progesterone receptor agents, 24 estrogen receptor agents, hormone replacement therapy, and antifibrinolytic treatment. We did not review trials in which medications were used as adjuncts and in which all participants were

2017 Effective Health Care Program (AHRQ)

117. Human Papillomavirus Vaccination

are reassuring. The HPV vaccines are recommended for girls and boys aged 11–12 years and can be given to females and males up to age 26 years. The Advisory Committee on Immunization Practices and the American College of Obstetricians and Gynecologists recommend routine HPV vaccination for girls and boys at the target age of 11–12 years (but it may be given from the age of 9 years) as part of the adolescent immunization platform in order to help reduce the incidence of anogenital cancer and genital warts (...) routine HPV vaccination for girls and boys at the target age of 11–12 years (but it may be given from the age of 9 years) as part of the adolescent immunization platform in order to help reduce the incidence of anogenital cancer and genital warts associated with HPV infection. Bivalent, quadrivalent, and 9-valent vaccines are approved for females aged 9–26 years and quadrivalent and 9-valent vaccines are approved for males aged 9–26 years. Recently, the bivalent vaccine has been withdrawn from the U.S

2017 American College of Obstetricians and Gynecologists

118. HTA of HPV testing for cervical cancer screening

Assessment – Providing advice that enables the best outcome for people who use our health service and the best use of resources by evaluating the clinical effectiveness and cost-effectiveness of drugs, equipment, diagnostic techniques and health promotion and protection activities. ? Health Information – Advising on the efficient and secure collection and sharing of health information, setting standards, evaluating information resources and publishing information about the delivery and performance (...) equivalent was run from 2011 until 2014. HPV 6 and HPV 11 are associated with approximately 90% of anogenital wart cases. HPV 16 and HPV 18 are associated with approximately 70% of squamous cell carcinomas (the most common histological type of cervical cancer globally and in Ireland). Cervical screening of women who have been vaccinated against HPV is recommended because the current quadrivalent vaccine does not protect against cervical cancers caused by other high-risk HPV types. The first cohort

2017 Health Information and Quality Authority

119. Sialanar (glycopyrronium) - for treating severe drooling of saliva in children and adolescents (aged 3 years and above) with conditions affecting the nervous system, such as cerebral palsy, epilepsy and neurodegenerative diseases

consultation 132 6. Benefit-risk balance 133 7. Recommendations following re-examination 139 Assessment report EMA/CHMP/436684/2016 Page 4/143 List of abbreviations Ach acetylcholine ADI acceptable daily intake ADRs adverse drug reactions AE adverse event ALP alkaline phosphatase ALT alanine aminotransferase AP Applicant’s Part (or Open Part) of a ASMF API Active Pharmaceutical Ingredient APPM Association of Paediatric Palliative Medicine Master Formulary AR Assessment Report ASM Active Substance (...) -examination procedure 10 2. Scientific discussion 10 2.1. Introduction 10 2.2. Quality aspects 16 2.2.1. Introduction 16 2.2.2. Active Substance 16 2.2.3. Finished Medicinal Product 17 2.2.4. Discussion on chemical, pharmaceutical and biological aspects 19 2.2.5. Conclusions on the chemical, pharmaceutical and biological aspects 19 2.2.6. Recommendations for future quality development 19 2.3. Non-clinical aspects 20 2.3.1. Introduction 20 2.3.2. Pharmacology 20 2.3.3. Pharmacokinetics 21 2.3.4. Toxicology

2016 European Medicines Agency - EPARs

120. Communication strategies for the prevention of HIV, STI and hepatitis among MSM in Europe

support 24 Table 17: Prevention messages about stigma, discrimination, and the law 25 Table 18: Comparison of common communication channels and methods 40 TECHNICAL DOCUMENT Communication strategies for the prevention of HIV, STI and hepatitis among MSM in Europe v Abbreviations AIDS Acquired immune deficiency syndrome ART Anti-retroviral therapy ECDC European Centre for Disease Prevention and Control EEA European Economic Area EMIS European MSM Internet Survey EU European Union GLBTIQ Gay, lesbian (...) drug use 18 Table 9: Prevention messages about negotiated safety 19 Table 10: Prevention messages about serosorting 20 Table 11: Prevention messages about ART to prevent transmission of HIV 21 Table 12: Prevention messages about PEP and PrEP 21 Table 13: Prevention messages about hepatitis A and B vaccination: 22 Table 14: Prevention messages about hepatitis C 23 Table 15: Prevention messages about making personal risk assessments 23 Table 16. Prevention messages about empowerment and psychosocial

2016 European Centre for Disease Prevention and Control - Technical Guidance

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