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Wart Immune Therapy

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41. Topical NVN1000 for the Treatment of External Genital and Perianal Warts

Criteria: At least 2 but not more than 20 genital/perianal warts with a maximum total wart surface area no more than 1% body surface area If a woman of child-bearing potential, have a negative pregnancy test and use effective contraception If currently receiving wart treatment, be willing to stop all treatment for 28 days prior to randomization and during the study Exclusion Criteria: Immunocompromised patients including those with HIV, receiving radiation, or drugs that suppress the immune system (...) ): Novan, Inc. Study Details Study Description Go to Brief Summary: A Phase 2 Multi-Center, Double-Blind, Randomized, Vehicle-Controlled, Ascending Dose Study Assessing Tolerability, Safety, and Efficacy of Topical NVN1000 in Subjects with External Genital Warts and Perianal Warts Condition or disease Intervention/treatment Phase Genital Warts Perianal Warts Drug: NVN1000 8% Gel Drug: NVN1000 16% Drug: Vehicle Drug: NVN1000 24% Phase 2 Detailed Description: This is a phase 2, multi-center, randomized

2015 Clinical Trials

42. Evaluate the Effectiveness and Safety of DPCP Ointment (Samcyproneâ„¢) on the Clearance of Verruca Vulgaris (Common Warts)

. A maximum of four (4) cutaneous single warts or one (1) area of clustered or adjacent warts up to 80 mm will be treated Exclusion Criteria: Genital warts may not be selected as target warts Subjects that are immuno-compromised Presence of systemic or localized diseases, conditions, or medications that could interfere with assessment of safety and efficacy or that compromise immune function Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you (...) , not recruiting First Posted : December 29, 2015 Last Update Posted : February 23, 2018 Sponsor: RXi Pharmaceuticals, Corp. Information provided by (Responsible Party): RXi Pharmaceuticals, Corp. Study Details Study Description Go to Brief Summary: Warts are benign epidermal tumors caused by human papillomaviruses (HPVs). The active pharmaceutical ingredient DPCP has been used for many years as a compounded formulation in acetone for the treatment of warts, alopecia areata and more recently, cutaneous

2015 Clinical Trials

43. Nanopulse Efficacy Study for the Treatment of Common Warts

-the-counter treatments, but not by any prescription medicine, surgery, or destructive procedure (i.e., cryotherapy) within four weeks of the date the subject is recruited into the study. Subject's wart and the subject must be suitable candidates for usual Standard of Care treatments. Standard of care for common warts is defined as curettage and electrodesication, cryotherapy, topical therapy or surgery. Subject must be competent to provide informed consent. If the subject is female, and of childbearing (...) current treatment modalities in terms of increased ease of use, faster patient healing and minimal scarring with fewer complications resulting from treatment. The device emits significantly less energy than existing electro-surgery or electro-cautery equipment and is believed to be similar to laser therapy treatment of warts. Trained clinicians can usually diagnose warts based by their appearance and location . Non-genital warts are subcategorized into common, periungual, flat, filiform, and plantar

2015 Clinical Trials

44. Safety and Efficacy of Varying Regimens of CANDIN for Treatment of Common Warts (Verruca Vulgaris)

diseases, conditions, or medications that could interfere with assessment of safety and efficacy or that compromise immune function including psoriasis Subject has been diagnosed with diabetes mellitus Subject has a history of keloid formation Injectable common wart(s) located in areas with existing dermatologic conditions (such as psoriasis) or with an underlying inflammatory conditions (such as arthritic joints), or tattoos or implants/piercing/hardware or marking that may conceal responses (...) Primary Completion Date : January 2018 Actual Study Completion Date : March 2018 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Cohort 1 0.3 mL of CANDIN administered intralesionally in the largest common wart Biological: CANDIN Candida albicans Skin Test Antigen for Cellular Hypersensitivity Experimental: Cohort 2 0.5 mL of CANDIN administered intralesionally in the largest common wart Biological

2015 Clinical Trials

45. Vaginal Microbiome Exposure and Immune Responses in C-section Infants

diseases, including allergies and asthma. Some researchers think one reason for this is that passing through the mother's vaginal canal during birth exposes the baby to bacteria that promote healthy immune system development, something that C-section babies don't get. Transferring these potentially beneficial vaginal bacteria to C-section babies may help prevent some diseases later. Condition or disease Intervention/treatment Phase Allergic Diseases Asthma Biological: C-section -Vaginal seeding Drug: C (...) or current medical problems or findings from physical examination or laboratory testing that are not listed above, which, in the opinion of the investigator may: Pose additional risks from participation in the study, Interfere with the participant's ability to comply with study requirements, or May impact the quality or interpretation of the data obtained from the study. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may

2018 Clinical Trials

46. Warts and wart virus antibodies in patients with systemic lupus erythematosus. Full Text available with Trip Pro

Warts and wart virus antibodies in patients with systemic lupus erythematosus. Warts were found in 25 out of 56 patients with definite or probable systemic lupus erythematosus (SLE) but in only 19 out of 160 control patients. Warts were particularly prevalent in elderly patients with SLE. The corticosteroid and antimalarial drugs used to treat SLE did not influence the frequency of warts. Wart-virus antibodies were found significantly less often in patients with SLE than in controls: antibodies (...) were detected in 23 out of 51 patients and in 40 out of 54 controls. Ihe findings suggest that some deficiency in the immune mechanisms of patients with SLE predisposes them to develop warts. There was an inverse correlation among the patients with SLE between the occurrence of warts and rheumatoid factor activity. This suggests that rheumatoid factor may interfere with resistance to warts.

1977 British medical journal

47. Diagnosis of HIV-Associated Oral Lesions in Relation to Early versus Delayed Antiretroviral Therapy: Results from the CIPRA HT001 Trial. Full Text available with Trip Pro

<0.01). In comparison to the early group, there was a significantly higher incidence of candidiasis, hairy leukoplakia, herpes labialis, and recurrent herpes simplex in the delayed group. The incidence of oral warts in delayed group was 0.97 before therapy and 4.27 post-ART initiation (p-value <0.01). In the delayed group the incidence of oral warts post-ART initiation was significantly higher than that seen in the early group (4.27 versus 1.09; p-value <0.01). The incidence of oral warts increased (...) after ART was initiated, and relative to the early group there was a four-fold increase in oral warts if ART was initiated following an AIDS diagnosis. Based upon our findings, candidiasis, hairy leukoplakia, herpes labialis, and recurrent herpes simplex indicate immune suppression and the need to start ART. In contrast, oral warts are a sign of immune reconstitution following ART initiation.

2016 PloS one Controlled trial quality: uncertain

48. Development of a potent invigorator of immune responses endowed with both preventive and therapeutic properties Full Text available with Trip Pro

Development of a potent invigorator of immune responses endowed with both preventive and therapeutic properties This article reviews briefly the making of an immunoprophylactic-cum-immunotherapeutic vaccine against leprosy. The vaccine is based on cultivable, heat-killed atypical mycobacteria, whose gene sequence is now known. It has been named Mycobacterium indicus pranii. It has received the approval of the Drug Controller General of India and the US Food and Drug Administration. Besides (...) leprosy, M. indicus pranii has found utility in the treatment of category II ("difficult to treat") tuberculosis. It also heals ugly anogenital warts. It has preventive and therapeutic action against SP2/O myelomas. It is proving to be a potent adjuvant for enhancing antibody titers of a recombinant vaccine against human chorionic gonadotropin, with the potential of preventing pregnancy without derangement of ovulation and menstrual regularity in sexually active women.

2017 Biologics : targets & therapy

49. Absence of γ-chain in keratinocytes alters chemokine secretion resulting in reduced immune cell recruitment. Full Text available with Trip Pro

Absence of γ-chain in keratinocytes alters chemokine secretion resulting in reduced immune cell recruitment. Loss-of-function mutations in the common gamma (γc) chain cytokine receptor subunit give rise to severe combined immunodeficiency characterized by lack of T and natural killer cells and infant death from infection. Hematopoietic stem cell transplantation or gene therapy offer a cure, but despite successful replacement of lymphoid immune lineages, a long-term risk of severe cutaneous (...) -deficient keratinocytes also exhibit defective induction of T-cell chemotaxis in a model of stable human papilloma virus-18 infection. These findings suggest that persistent γc-deficiency in keratinocytes alters immune cell recruitment to the skin, which may contribute to the development and persistence of warts in this condition and would require different treatment approaches.Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

2017 Journal of Investigative Dermatology

50. Carbon Dioxide Laser vs. Electrocoagulation for the Therapy of Condyloma

: December 2020 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Carbon dioxide Laser ablation Excision of genital warts using a carbon dioxide laser, ie CO2 Laser Device: Carbon dioxide Laser ablation surgical Instrument to achieve excision of genital warts by a pulsed laser of 15 Watt voltage Active Comparator: Electrocoagulation Excision of genital warts using a superficial electrical (...) language barrier pregnancy unwillingness to participate the use of blood thinner or known coagulation disorder the use of immunosuppressive medicament HIV-Infection malignant diseases local therapy within 8 weeks before Treatment wound healing disorder Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study

2015 Clinical Trials

51. Imiquimod in the treatment of cutaneous warts: an evidence-based review. (Abstract)

for the treatment of anogenital warts by the US Food and Drug Administration. However, the efficacy of imiquimod in the treatment of cutaneous warts has not been well established.The purpose of this article is to systematically review the published literature regarding the efficacy of imiquimod in the treatment of cutaneous warts, and to evaluate the quality and outcomes of these studies.A literature search was performed through clinical queries PubMed (National Library of Medicine) database and the Cochrane (...) Imiquimod in the treatment of cutaneous warts: an evidence-based review. Cutaneous warts are highly prevalent lesions caused by the infection of keratinocytes by different types of human papillomaviruses. Although cutaneous warts are capable of resolving spontaneously, these infections can persist for long periods of time by evading the host immune system, and, as a result, many patients choose to seek treatment. Imiquimod is an immune response modifier that is approved as a topical cream

2014 American journal of clinical dermatology

52. Genital warts. (Abstract)

Genital warts. Anogenital warts (AGWs) are a very common disease. They are caused mostly by low-risk human papillomaviruses (HPV) 6 and 11, particularly the former. Clinical presentation is mostly of growths in the areas of friction of the anogenital region. The treatment is classified as patient/home applied or administered by a professional. In cases with atypical presentations or resistance to recommended therapies, great care should be taken to establish a differential diagnosis taking (...) into account normal anatomical variations, infectious etiologies, precancers and cancers, as well as benign dermatological growths. The prevention of AGWs can be achieved by the use of the quadrivalent prophylactic HPV vaccine administered prior to sexual debut, as well as the meticulous use of condoms. Where coverage of the quadrivalent vaccine has been high, marked reductions in AGWs are being seen in young women of vaccine-eligible age, as well as in young males (as herd immunity effect). Copyright ©

2014 Best practice & research. Clinical obstetrics & gynaecology

53. Warts, Nongenital (Follow-up)

), and diphencyclopropenone (DCP) are contact sensitizers. Trichloroacetic acid is a caustic compound that causes tissue necrosis. Podophyllin is a cytotoxic compound used more commonly in the treatment of genital warts. Aminolevulinic acid (ALA) is a photosensitizer that has been successfully used topically in combination with blue light to treat flat warts. [ ] Several prescription medications have proven beneficial in treating warts. These can be applied at home by the patient. Imiquimod is an immune response modifier (...) DNA in the plume of erbium:YAG laser-treated warts. J Am Acad Dermatol . 1998 Mar. 38(3):426-8. . Rivera A, Tyring SK. Therapy of cutaneous human Papillomavirus infections. Dermatol Ther . 2004. 17(6):441-8. . Media Gallery Plantar warts. Common wart on the hand. of 2 Tables Contributor Information and Disclosures Author Philip D Shenefelt, MD, MS Professor, Department of Dermatology and Cutaneous Surgery, University of South Florida College of Medicine; Past Chief, Section of Dermatology, James

2014 eMedicine.com

54. Warts, Genital (Follow-up)

treatments are available. All medicines used to treat HPV disease are applied topically on cutaneous surfaces. Local skin reactions and pain are common adverse effects. Do not apply any of these medications to mucosal surfaces, and do not use them to treat dysplastic lesions, squamous cell carcinoma (SCC), verrucous carcinoma, or Bowenoid papulosis. Two broad categories of medications are effective in treating HPV disease: Immune response modifiers – These include imiquimod and interferon alfa (...) and are primarily used in treatment of external anogenital warts or condylomata acuminata Cytotoxic agents - These include the antiproliferative drugs podofilox, podophyllin, and 5-FU, as well as the chemodestructive or keratolytic agents salicylic acid, trichloroacetic acid (TCA), and bichloracetic acid (BCA) None of these medicines have been shown to be uniformly effective or directly antiviral. The keratolytics are the only agents that are recommended for treatment of nongenital cutaneous warts. Imiquimod

2014 eMedicine.com

55. Warts, Genital (Overview)

and hyperchromic nuclei See for more detail. Management All medicines used to treat HPV disease are applied topically; they should not be applied to mucosal surfaces and should not be used to treat dysplastic lesions, squamous cell carcinoma, verrucous carcinoma, or Bowenoid papulosis. The following 2 broad categories of medications are effective: Immune response modifiers (eg, imiquimod and interferon alfa): These are primarily used in treatment of external anogenital warts or condylomata acuminata Cytotoxic (...) for routine screening In some cases, tissue biopsy can be used to confirm HPV infection. A biopsy is recommended for the following scenarios: Women with a history of vulvar dysplasia Postmenopausal women Women in whom medical therapy fails Clinical doubt about the diagnosis Histologic findings that can help elucidate the diagnosis include the following: Common cutaneous warts: Marked hyperkeratosis, acanthosis, parakeratosis, and papillomatosis; warts can be distinguished from other papillomas

2014 eMedicine.com

56. Warts, Nongenital (Treatment)

), and diphencyclopropenone (DCP) are contact sensitizers. Trichloroacetic acid is a caustic compound that causes tissue necrosis. Podophyllin is a cytotoxic compound used more commonly in the treatment of genital warts. Aminolevulinic acid (ALA) is a photosensitizer that has been successfully used topically in combination with blue light to treat flat warts. [ ] Several prescription medications have proven beneficial in treating warts. These can be applied at home by the patient. Imiquimod is an immune response modifier (...) DNA in the plume of erbium:YAG laser-treated warts. J Am Acad Dermatol . 1998 Mar. 38(3):426-8. . Rivera A, Tyring SK. Therapy of cutaneous human Papillomavirus infections. Dermatol Ther . 2004. 17(6):441-8. . Media Gallery Plantar warts. Common wart on the hand. of 2 Tables Contributor Information and Disclosures Author Philip D Shenefelt, MD, MS Professor, Department of Dermatology and Cutaneous Surgery, University of South Florida College of Medicine; Past Chief, Section of Dermatology, James

2014 eMedicine.com

57. Warts, Genital (Treatment)

treatments are available. All medicines used to treat HPV disease are applied topically on cutaneous surfaces. Local skin reactions and pain are common adverse effects. Do not apply any of these medications to mucosal surfaces, and do not use them to treat dysplastic lesions, squamous cell carcinoma (SCC), verrucous carcinoma, or Bowenoid papulosis. Two broad categories of medications are effective in treating HPV disease: Immune response modifiers – These include imiquimod and interferon alfa (...) and are primarily used in treatment of external anogenital warts or condylomata acuminata Cytotoxic agents - These include the antiproliferative drugs podofilox, podophyllin, and 5-FU, as well as the chemodestructive or keratolytic agents salicylic acid, trichloroacetic acid (TCA), and bichloracetic acid (BCA) None of these medicines have been shown to be uniformly effective or directly antiviral. The keratolytics are the only agents that are recommended for treatment of nongenital cutaneous warts. Imiquimod

2014 eMedicine.com

58. Warts, Genital (Treatment)

is delivered to the affected lesions, causing tissue coagulation and necrosis. Treatment is successful in about 80% of cases. Immune-based therapy Physician administered treatments include acid applications (bichloroacetic acid or trichloroacetic acid) and interferon injections with antiviral mechanisms. Medications for home use include imiquimod 5% cream, podofilox gel or solution, and antiproliferative compounds (5-fluorouracil). Vaccination [ , ] The 9-valent HPV vaccine (Gardasil 9 [9vHPV (...) of Pediatric Emergency Medicine, Departments of Emergency Medicine and Pediatrics, Kings County Hospital Center Binita R Shah, MD, FAAP is a member of the following medical societies: Disclosure: Nothing to disclose. What would you like to print? What would you like to print? Sections Genital Warts Find Us On About Membership WebMD Network Editions All material on this website is protected by copyright, Copyright © 1994-2019 by WebMD LLC. This website also contains material copyrighted by 3rd parties

2014 eMedicine Emergency Medicine

59. Warts, Plantar (Treatment)

), and diphencyclopropenone (DCP) are contact sensitizers. Trichloroacetic acid is a caustic compound that causes tissue necrosis. Podophyllin is a cytotoxic compound used more commonly in the treatment of genital warts. Aminolevulinic acid (ALA) is a photosensitizer that has been successfully used topically in combination with blue light to treat flat warts. [ ] Several prescription medications have proven beneficial in treating warts. These can be applied at home by the patient. Imiquimod is an immune response modifier (...) DNA in the plume of erbium:YAG laser-treated warts. J Am Acad Dermatol . 1998 Mar. 38(3):426-8. . Rivera A, Tyring SK. Therapy of cutaneous human Papillomavirus infections. Dermatol Ther . 2004. 17(6):441-8. . Media Gallery Plantar warts. Common wart on the hand. of 2 Tables Contributor Information and Disclosures Author Philip D Shenefelt, MD, MS Professor, Department of Dermatology and Cutaneous Surgery, University of South Florida College of Medicine; Past Chief, Section of Dermatology, James

2014 eMedicine Emergency Medicine

60. Warts, Genital (Diagnosis)

and hyperchromic nuclei See for more detail. Management All medicines used to treat HPV disease are applied topically; they should not be applied to mucosal surfaces and should not be used to treat dysplastic lesions, squamous cell carcinoma, verrucous carcinoma, or Bowenoid papulosis. The following 2 broad categories of medications are effective: Immune response modifiers (eg, imiquimod and interferon alfa): These are primarily used in treatment of external anogenital warts or condylomata acuminata Cytotoxic (...) for routine screening In some cases, tissue biopsy can be used to confirm HPV infection. A biopsy is recommended for the following scenarios: Women with a history of vulvar dysplasia Postmenopausal women Women in whom medical therapy fails Clinical doubt about the diagnosis Histologic findings that can help elucidate the diagnosis include the following: Common cutaneous warts: Marked hyperkeratosis, acanthosis, parakeratosis, and papillomatosis; warts can be distinguished from other papillomas

2014 eMedicine.com

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