How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

445 results for

Wart Immune Therapy

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

21. A Phase 3 Study to Evaluate the Efficacy and Safety of CLS006 Versus Vehicle in Subjects 2 Years of Age or Older With Cutaneous Common Warts

urine pregnancy test at Screening and Baseline Subjects free of any clinically significant dermatologic disorder in the treatment area Subjects free of any clinically significant systemic condition which will interfere with the study assessments or increase the risk of AEs Subjects willing to refrain from using other topical products in the treatment area, or prohibited medications for the duration of the study Exclusion Criteria: Subjects who have used any wart treatments/therapies, prescription (...) with immunotherapy (DPCP, DNCB or other), imiquimod, 5-fluorouracil,bleomycin, podophyllin or any other wart immunotherapy or treatment (e.g., Candida antigen) designed to stimulate immune response within 12 weeks of the Baseline Visit. Subjects who are immunocompromised. Subjects who have taken, within 30 days prior to the Baseline visit, or require treatment with systemic immunosuppressive or immunomodulatory medication (including oral or parenteral corticosteroids) during the course of the study Subjects who

2016 Clinical Trials

22. Study of Leukocyte Interleukin, Injection for Treatment of Perianal Warts

Study of Leukocyte Interleukin, Injection for Treatment of Perianal Warts Study of Leukocyte Interleukin, Injection for Treatment of Perianal Warts - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Study (...) of Leukocyte Interleukin, Injection for Treatment of Perianal Warts (PAW) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03038828 Recruitment Status : Terminated (Insufficient enrollment) First Posted : February 1, 2017 Last Update Posted : February 11, 2019 Sponsor: CEL-SCI Corporation Collaborators

2016 Clinical Trials

23. A Study of A-101 Solution in Subjects With Common Warts.

on the trunk or extremities Subject is immune compromised (due to chemotherapy, systemic steroids, genetic immunodeficiency, transplant status, etc.) Subject has a history of Human Immunodeficiency Virus (HIV) infection Subject has had any Human Papilloma Virus (HPV) vaccine within 1 year prior to enrollment Subject has used any of the following intralesional therapies within the specified period prior to enrollment to the Target Wart: Immunotherapy (Candida antigen, mumps antigen, Trichophyton antigen (...) ); Anti-metabolite therapy (bleomycin, 5-fluorouracil) Subject has used any of the following systemic therapies within the specified period prior to enrollment: Immunomodulatory/immunosuppressant therapy (e.g., etanercept, alefacept, infliximab); Glucocortico-steroids (inhaled and intra-nasal steroids are permitted); Subject has used any of the following topical therapies within the specified period prior to enrollment on, or in a proximity to the Target Wart, which in the Investigator's opinion

2016 Clinical Trials

24. Risk factors for recurrence after successful treatment of warts: the role of smoking habits. (PubMed)

Risk factors for recurrence after successful treatment of warts: the role of smoking habits. Several therapies have been proposed for cutaneous warts without results concerning factors affecting recurrences.To determine the importance of individual characteristics and different therapy modalities in the occurrence of relapses.Observational prospective cohort study including 199 patients affected by multiple plantar warts treated as follows: 49 with keratolytics, 50 with CO2 laser, 50 (...) with pulsed dye laser (PDL) and 50 with cryotherapy. Personal data were evaluated through a questionnaire, and treatment information was collected. A Cox regression analysis was performed to identify independent factors for relapse occurrence.Of patients, 57.8% showed a persistent clearance of warts after treatment with a higher recurrence-free interval when treated with PDL. Accordingly, the risk of recurrence was increased with CO2 laser [hazard ratio (HR) 2.92, 95% confidence interval (CI) 1.49-5.74

2016 Journal of the European Academy of Dermatology and Venereology

25. Effectiveness Study of Human Papilloma Virus (HPV) Vaccines to Prevent Recurrence of Genital Warts

Recruitment Status : Recruiting First Posted : April 25, 2016 Last Update Posted : October 29, 2018 See Sponsor: University of Pretoria Collaborator: University of Stellenbosch Information provided by (Responsible Party): Professor Greta Dreyer, University of Pretoria Study Details Study Description Go to Brief Summary: Large genital warts are frequently diagnosed in general gynaecology and oncology clinics in South Africa. Medical and destructive therapy for small warts is generally very effective (...) , however unique problems posed by large or extensive genital warts are not so easily solved and treatment of affected patients remains very challenging. Recurrences are common especially among immune-compromised women. This study will test whether giving the quadrivalent human papilloma virus (HPV) vaccine to women with extensive genital warts prior to surgical treatment will improve outcomes. Investigators hypothesize that pre-treatment with HPV vaccine can play a role in the control of both malignant

2016 Clinical Trials

26. Immune Response and General Immune Health in Subjects Infected With Herpes Simplex Virus Type 1 (HSV-1)

Immune Response and General Immune Health in Subjects Infected With Herpes Simplex Virus Type 1 (HSV-1) Immune Response and General Immune Health in Subjects Infected With Herpes Simplex Virus Type 1 (HSV-1) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Immune Response and General Immune Health in Subjects Infected With Herpes Simplex Virus Type 1 (HSV-1) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03661541 Recruitment Status : Completed First Posted : September 7, 2018 Last Update Posted

2018 Clinical Trials

27. British Association of Dermatologists and British photodermatology Group guidelines for topical photodynamic therapy

hyperplasia, viral warts, vulval lichen sclerosus, vulvodynia, wound healing and Zoon balanitis. © 2018 British Association of Dermatologists British Journal of Dermatology (2018) 4 BAD and BPG guidelines for topical photodynamic therapy 2018, T.H. Wong et al.? where the Paget cell in?ltrate is less dense ? when there is limited adnexal involvement. R20 ( ) Consider PDT as a treatment option for EMPD either before or after surgery. R21 ( ) Consider CO 2 laser prior to PDT as a treatment option for EMPD (...) British Association of Dermatologists and British photodermatology Group guidelines for topical photodynamic therapy GUIDELINE BJD British Journal of Dermatology British Association of Dermatologists and British Photodermatology Group guidelines for topical photodynamic therapy 2018 T.H. Wong, 1 C.A. Morton, 1 N. Collier, 2 A. Haylett, 2 S. Ibbotson, 3 K.E. McKenna, 4 R. Mallipeddi, 5 H. Moseley, 3 D.C. Seukeran, 6 L.E. Rhodes, 2 K.A. Ward, 7 M.F. Mohd Mustapa 8 and L.S. Exton 8 1 Stirling

2019 British Association of Dermatologists

28. Warts and verrucae

and compromised immunity. Extensive warts. Persistent warts that are unresponsive to available primary care treatments Treatment options in secondary care include: Physical ablation (for example surgery, laser treatment, and photodynamic treatment). Antimitotic treatments (for example topical podophyllotoxin and topical or oral retinoids). Immunomodulatory treatments such as topical sensitizers. Virucidal treatments such as formaldehyde and glutaraldehyde). Have I got the right topic? Have I got the right (...) acid preparations that may be prescribed on an FP10 see the section on . Cryotherapy with liquid nitrogen (usually carried out every 2 weeks for up to 3–4 months until the wart is gone, or for a maximum of 6 treatments). Note, cryotherapy is only suitable for older children who are likely to tolerate this treatment. For information on who should not receive cryotherapy, see the section on . Combination therapy with salicylic acid and cryotherapy (applying topical salicylic acid preparations between

2014 NICE Clinical Knowledge Summaries

29. Complete Healing of a Giant Wart in a Severely Immune-Compromised Patient with HIV Infection Treated with Acupuncture (PubMed)

disease, who developed a monstrous wart covering the entirety of the radial district of his right hand. He was completely healed after a long treatment with traditional Chinese acupuncture, in spite of minimal immune recovery induced by efficacious antiretroviral therapy. To the best of our knowledge, therefore, the present report may be the first direct clinical evidence that acupuncture may be effective in the treatment of cutaneous warts also in HIV-infected patients. (...) Complete Healing of a Giant Wart in a Severely Immune-Compromised Patient with HIV Infection Treated with Acupuncture Giant warts are infrequent dermatological viral infections caused by Papillomavirus (HPV) in immune-compromised patients. Treatment may often be difficult and unsatisfactory, either by surgery or cytotoxic agents, because of poor immune control of viral activity in such hosts. Here we report on the case of a patient with advanced and persistent immune suppression caused by HIV

Full Text available with Trip Pro

2011 Case reports in dermatology

30. Cimetidine wart therapy

wart therapy Aka: Cimetidine wart therapy From Related Chapters II. Indication Recalcitrant warts in adults in Children III. Mechanism Mild Immune enhancing effect IV. Dosing Start: 25-40 mg/kg (MAX 400 mg tid) divided bid-tid Course: Treat for 2-3 months V. Side effects Unpleasant syrup s with prolonged use VI. Efficacy: Mild effect Not nearly as pronounced as originally thought VII. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing (...) Cimetidine wart therapy Cimetidine wart therapy Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Cimetidine wart therapy Cimetidine

2015 FP Notebook

31. Nanopulse Efficacy Study for the Treatment of Common Warts

current treatment modalities in terms of increased ease of use, faster patient healing and minimal scarring with fewer complications resulting from treatment. The device emits significantly less energy than existing electro-surgery or electro-cautery equipment and is believed to be similar to laser therapy treatment of warts. Trained clinicians can usually diagnose warts based by their appearance and location . Non-genital warts are subcategorized into common, periungual, flat, filiform, and plantar (...) types. Common warts are benign, often skin-colored, or brown-grey, rough, bumpy growths on the hands and feet (caused by Human Papilloma Virus type 2) . Common warts in individuals without any immune deficiencies are low risk and are the focus of this study.Based upon the preclinical profile of the Nanopulse device, particularly its safety profile and its effect on transformed cells, it is hypothesized that application of pulses from the Nanopulse System , will result in complete clinical clearance

2015 Clinical Trials

32. Topical NVN1000 for the Treatment of External Genital and Perianal Warts

Criteria: At least 2 but not more than 20 genital/perianal warts with a maximum total wart surface area no more than 1% body surface area If a woman of child-bearing potential, have a negative pregnancy test and use effective contraception If currently receiving wart treatment, be willing to stop all treatment for 28 days prior to randomization and during the study Exclusion Criteria: Immunocompromised patients including those with HIV, receiving radiation, or drugs that suppress the immune system (...) Topical NVN1000 for the Treatment of External Genital and Perianal Warts Topical NVN1000 for the Treatment of External Genital and Perianal Warts - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Topical

2015 Clinical Trials

33. Imiquimod in the treatment of cutaneous warts: an evidence-based review. (PubMed)

Imiquimod in the treatment of cutaneous warts: an evidence-based review. Cutaneous warts are highly prevalent lesions caused by the infection of keratinocytes by different types of human papillomaviruses. Although cutaneous warts are capable of resolving spontaneously, these infections can persist for long periods of time by evading the host immune system, and, as a result, many patients choose to seek treatment. Imiquimod is an immune response modifier that is approved as a topical cream (...) studies, the combined rate of patients achieving complete response to therapy was 44%, ranging from 27 to 89%. However, there was variation in the dose frequency and application among these studies. In immunosuppressed patients, two studies and four case reports were identified. Clinical improvement was seen in 33-50% of patients, with no patients experiencing complete clinical clearance.There have been several studies demonstrating the successful use of imiquimod to treat recalcitrant cutaneous warts

2014 American journal of clinical dermatology

34. Genital warts. (PubMed)

Genital warts. Anogenital warts (AGWs) are a very common disease. They are caused mostly by low-risk human papillomaviruses (HPV) 6 and 11, particularly the former. Clinical presentation is mostly of growths in the areas of friction of the anogenital region. The treatment is classified as patient/home applied or administered by a professional. In cases with atypical presentations or resistance to recommended therapies, great care should be taken to establish a differential diagnosis taking (...) into account normal anatomical variations, infectious etiologies, precancers and cancers, as well as benign dermatological growths. The prevention of AGWs can be achieved by the use of the quadrivalent prophylactic HPV vaccine administered prior to sexual debut, as well as the meticulous use of condoms. Where coverage of the quadrivalent vaccine has been high, marked reductions in AGWs are being seen in young women of vaccine-eligible age, as well as in young males (as herd immunity effect). Copyright ©

2014 Best practice & research. Clinical obstetrics & gynaecology

35. Warts - anogenital

, and cause anxiety or distress. Possible complications associated with treatment include: Persistent hypo- or hyper-pigmentation due to ablative therapy. Hypertrophic scarring. Bleeding, infection, or scarring due to surgical removal. [ ; ] Prognosis What is the prognosis for people with anogenital warts? Anogenital warts are benign and usually asymptomatic. Left untreated, anogenital warts will resolve spontaneously in 10–30% of people within 3 months Within 6 months, anogenital warts spontaneously (...) the choice of treatment is dependent upon the: Type of warts — soft non-keratinised warts respond well to podophyllotoxin, and trichloroacetic acid (TCA). Keratinised lesions may be better treated with physical ablative methods such as cryotherapy, excision, TCA or electrocautery. Imiquimod is suitable treatment for both keratinised and non-keratinised warts. Number and volume of warts — a small number of low volume warts, irrespective of type, can be treated with ablative therapy, or topical treatment

2012 NICE Clinical Knowledge Summaries

36. Warts, Genital (Diagnosis)

for routine screening In some cases, tissue biopsy can be used to confirm HPV infection. A biopsy is recommended for the following scenarios: Women with a history of vulvar dysplasia Postmenopausal women Women in whom medical therapy fails Clinical doubt about the diagnosis Histologic findings that can help elucidate the diagnosis include the following: Common cutaneous warts: Marked hyperkeratosis, acanthosis, parakeratosis, and papillomatosis; warts can be distinguished from other papillomas (...) and hyperchromic nuclei See for more detail. Management All medicines used to treat HPV disease are applied topically; they should not be applied to mucosal surfaces and should not be used to treat dysplastic lesions, squamous cell carcinoma, verrucous carcinoma, or Bowenoid papulosis. The following 2 broad categories of medications are effective: Immune response modifiers (eg, imiquimod and interferon alfa): These are primarily used in treatment of external anogenital warts or condylomata acuminata Cytotoxic

2014 eMedicine.com

37. Warts, Genital (Treatment)

Warts, Genital (Treatment) Human Papillomavirus (HPV) Treatment & Management: Approach Considerations, Considerations in Specific Patient Subgroups, Pharmacologic Therapy Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) squamous intraepithelial lesions (SILs). Treatment is reserved for patients with visible warts. The general treatment strategy is to eliminate as many of the visible lesions as possible until the host immune system can control viral replication. Treatment is not recommended for subclinical anogenital or mucosal human papillomavirus (HPV) infection in the absence of coexistent dysplasia. No evidence demonstrates that treatment eliminates HPV infection or that it decreases infectivity. In fact, warts may

2014 eMedicine.com

38. Warts, Nongenital (Treatment)

, or symptomatic warts or warts that have been present for more than 2 years. Topical agents Salicylic acid is a first-line therapy used to treat warts. [ ] It is available without a prescription and can be applied by the patient at home. Cure rates from 70-80% are reported. A nonblinded, randomized controlled trial compared treatment of plantar warts with 50% salicylic acid topical (Verrugon) applied daily with cryotherapy with liquid nitrogen (up to 4 treatments 2-3 wk apart). The study found no significant (...) ), and diphencyclopropenone (DCP) are contact sensitizers. Trichloroacetic acid is a caustic compound that causes tissue necrosis. Podophyllin is a cytotoxic compound used more commonly in the treatment of genital warts. Aminolevulinic acid (ALA) is a photosensitizer that has been successfully used topically in combination with blue light to treat flat warts. [ ] Several prescription medications have proven beneficial in treating warts. These can be applied at home by the patient. Imiquimod is an immune response modifier

2014 eMedicine.com

39. Warts, Genital (Overview)

for routine screening In some cases, tissue biopsy can be used to confirm HPV infection. A biopsy is recommended for the following scenarios: Women with a history of vulvar dysplasia Postmenopausal women Women in whom medical therapy fails Clinical doubt about the diagnosis Histologic findings that can help elucidate the diagnosis include the following: Common cutaneous warts: Marked hyperkeratosis, acanthosis, parakeratosis, and papillomatosis; warts can be distinguished from other papillomas (...) and hyperchromic nuclei See for more detail. Management All medicines used to treat HPV disease are applied topically; they should not be applied to mucosal surfaces and should not be used to treat dysplastic lesions, squamous cell carcinoma, verrucous carcinoma, or Bowenoid papulosis. The following 2 broad categories of medications are effective: Immune response modifiers (eg, imiquimod and interferon alfa): These are primarily used in treatment of external anogenital warts or condylomata acuminata Cytotoxic

2014 eMedicine.com

40. Warts, Nongenital (Follow-up)

, or symptomatic warts or warts that have been present for more than 2 years. Topical agents Salicylic acid is a first-line therapy used to treat warts. [ ] It is available without a prescription and can be applied by the patient at home. Cure rates from 70-80% are reported. A nonblinded, randomized controlled trial compared treatment of plantar warts with 50% salicylic acid topical (Verrugon) applied daily with cryotherapy with liquid nitrogen (up to 4 treatments 2-3 wk apart). The study found no significant (...) ), and diphencyclopropenone (DCP) are contact sensitizers. Trichloroacetic acid is a caustic compound that causes tissue necrosis. Podophyllin is a cytotoxic compound used more commonly in the treatment of genital warts. Aminolevulinic acid (ALA) is a photosensitizer that has been successfully used topically in combination with blue light to treat flat warts. [ ] Several prescription medications have proven beneficial in treating warts. These can be applied at home by the patient. Imiquimod is an immune response modifier

2014 eMedicine.com

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>