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Wart Immune Therapy

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21. A Study to Evaluate the Safety and Efficacy of CLS006 Versus Vehicle in Subjects 2 Years of Age or Older With Cutaneous Common Warts

to Evaluate the Efficacy and Safety of CLS006 Versus Vehicle in Subjects 2 Years of Age or Older With Cutaneous Common Warts Actual Study Start Date : October 30, 2017 Actual Primary Completion Date : August 22, 2018 Actual Study Completion Date : November 7, 2018 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: CLS006 Furosemide Topical Gel, 0.125% Drug: CLS006 Furosemide Topical Gel Experimental: CLS006 (...) and Baseline Subjects free of any clinically significant dermatologic disorder in the treatment area Subjects free of any clinically significant systemic condition which will interfere with the study assessments or increase the risk of AEs Subjects willing to refrain from using other topical products in the treatment area, or prohibited medications for the duration of the study Exclusion Criteria: Subjects who have used any wart treatments/therapies, prescription or over-the-counter, as follows: Salicylic

2017 Clinical Trials

22. Efficacy of Quadrivalent HPV Vaccine to Prevent Relapses of Genital Warts After Initial Therapeutic Response

Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: HPV Quadrivalent vaccine (QHV) Gardasil Biological: Vaccination with Gardasil Vaccination with Gardasil in patients apparently cured of external genital warts Placebo Comparator: Placebo Normal Saline Biological: Injection of Normal Saline Injection of Normal Saline in patients apparently cured of external genital warts Outcome Measures Go to Primary Outcome Measures : Relapse free survival (...) virus (HCV) or Hepatitis B virus (HBV) (Ag HBS) tests; Patients whose regular partner(s) have active uncontrolled clinical EGW; Patients who received the HPV Vaccine at any time before enrolment to the study; Any serious chronic or progressive disease according to the judgement of the investigator; Patients with history of an autoimmune disorder or any other known or suspected impairment /alteration of the immune system, or under immunosuppressive therapy including use of systemic corticosteroids

2017 Clinical Trials

23. Clinical Study : Efficacy and Safety of Three Cryotherapy Devices for Wart Treatment

: Randomized Intervention Model: Parallel Assignment Masking: Double (Investigator, Outcomes Assessor) Primary Purpose: Treatment Official Title: Clinical Trial to Demonstrate the Comparative Efficacy of a Cryogenic Treatment (Medical Device) In Common and Plantar Warts Management Actual Study Start Date : July 2015 Actual Primary Completion Date : November 2016 Actual Study Completion Date : November 2016 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go (...) for Pixie® are in line with the indications presented in the collected literature data, as well as with the indications of equivalent devices. The benefits of warts treatment without the use of chemicals are clearly evidenced. The treatment period is much shorter (one treatment compared to daily application of keratinolytics or fluorouracil, over a period of a few weeks). The cryogen therapy application through a conic tip is much more precise than with chemical substances. Chemical substance

2017 Clinical Trials

24. Intralesional Candidal Antigen Versus Intralesional Zinc Sulphate in Treatment of Cutaneous Warts

cytotoxic and natural killer cells to eradicate HPV infection. This clears not only the local warts but also distant warts unlike traditional wart therapies [ 11 ] . There are a few side effects reported by most of the studies. The most common side effect was pain and discomfort during injection, however, serious side effects such as vitiligo-like depigmentation and painful purple digit have also been reported [ 12 ] . Zinc is important for immune regulation as it stimulates the leucocytes and natural (...) common in children and adolescents. The prognosis of warts cannot be predicted. In some patients they may spontaneously disappear, whereas others show persistence and progression with spreading to other body sites, leading to physical and emotional distress to the patients. [ 1 ]. Condition or disease Intervention/treatment Phase Warts Drug: Candida Antigen Drug: Zinc Sulfate Phase 3 Detailed Description: Forty percent of children spontaneously clear in two years without treatment owing to natural

2017 Clinical Trials

25. Comparison Between Tuberculin Vaccine and Cryotherapy in Genital Wart Patients

Papilloma Virus infection among women in the world ranges from 2% to 44%. The conventional modalities in treatment of warts include destructive therapies such as salicylic acid, trichloroacetic acid, cryotherapy, silver nitrate, phenol, cantharidin, surgical interventions and laser, antiproliferative agents such as bleomycin, vitamin D analogs, podophyllin, 5 fluorouracil and antiviral agents such as cidofovir and retinoids. There are different mechanisms have been proposed for the resolution of warts (...) Trial) Estimated Enrollment : 45 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Comparison Between Tuberculin Vaccine and Cryotherapy in the Treatment of Genital Wart Patients Estimated Study Start Date : June 1, 2017 Estimated Primary Completion Date : June 2018 Estimated Study Completion Date : December 2018 Resource links provided by the National Library of Medicine related topics: available

2017 Clinical Trials

26. Intralesional Measles, Mumps, Rubella (MMR) Vaccine Versus Cryotherapy in Treatment of Multiple Common and Planter Warts

provided by the National Library of Medicine related topics: available for: resources: Arms and Interventions Go to Arm Intervention/treatment Experimental: MMR vaccine Measles-Mumps-Rubella Vaccine will be injected 0.5 ml into the largest wart at 2-week intervals until complete clearance was achieved or for a maximum of 3 treatments Drug: Measles-Mumps-Rubella Vaccine MMR vaccine will be injected 0.5 ml into the largest wart at 2-week intervals until complete clearance was achieved or for a maximum (...) or indirectly by fomites . Warts appear in various forms including verruca vulgaris, plane, plantar, filiform, digitate and periungual. Condition or disease Intervention/treatment Phase Common Wart Plantar Wart Drug: Measles-Mumps-Rubella Vaccine Procedure: cryotherapy Phase 4 Detailed Description: Treatment of warts is difficult for patients and physicians . Currently Available treatment options include cryosurgery, laser, electrosurgery, bleomycin, and topical keratolytic applications; many of them

2017 Clinical Trials

27. Carbon Dioxide Laser and Cryotherapy in Treatment of Warts

). Despite the presence of several therapeutic options, treatment of warts can present a challenge and they are not uniformly effective. Viral warts often disappear without treatment. In case of pain, discomfort and long duration they can be treated . Treatment options include cryotherapy, electrocautery, salicylic acid, immune therapy, minor surgery or laser surgery. Common warts have a distinctive appearance and can usually be diagnosed with the unaided eye; however, early growth stages and post (...) (Clinical Trial) Estimated Enrollment : 60 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Comparative Evaluation of Carbon Dioxide Laser and Cryotherapy by Dermoscopy in Treatment of Viral Wart Estimated Study Start Date : August 1, 2017 Estimated Primary Completion Date : August 1, 2018 Estimated Study Completion Date : August 1, 2019 Resource links provided by the National Library of Medicine related

2017 Clinical Trials

28. Immune Response and General Immune Health in Subjects Infected With Herpes Simplex Virus Type 1 (HSV-1)

acid dibutyl ester (SADBE) is a topical immunotherapeutic agent used in the treatment of verruca vulgaris and alopecia areata. During a recent FDA Compounding Advisory Committee Meeting, it was recommended that squaric acid dibutylester be included on the list of bulk drug substances allowed for use in compounding under section 503A of the Federal Food, Drug, and Cosmetic Act. And SADBE has now been so listed under section 503A. A study completed by Lee et al of 29 patients with recalcitrant warts (...) broadly similar ranges. Masking: None (Open Label) Primary Purpose: Screening Official Title: A Phase I Study of the Immune Response to Herpes Simplex Virus Type 1 (HSV-1) and General Immune Health in Subjects Infected With HSV-1 Actual Study Start Date : March 2, 2017 Actual Primary Completion Date : June 17, 2017 Actual Study Completion Date : October 25, 2017 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment

2018 Clinical Trials

29. Cimetidine wart therapy

wart therapy Aka: Cimetidine wart therapy From Related Chapters II. Indication Recalcitrant warts in adults in Children III. Mechanism Mild Immune enhancing effect IV. Dosing Start: 25-40 mg/kg (MAX 400 mg tid) divided bid-tid Course: Treat for 2-3 months V. Side effects Unpleasant syrup s with prolonged use VI. Efficacy: Mild effect Not nearly as pronounced as originally thought VII. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing (...) search on the term "Cimetidine wart therapy." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics in Pharmacology About FPnotebook.com is a rapid access, point-of-care medical reference for primary care and emergency clinicians. Started in 1995, this collection now contains 6656 interlinked topic pages divided into a tree of 31 specialty books and 728 chapters. Content is with systematic literature reviews

2015 FP Notebook

30. Immunizations - childhood

disease , commonly referred to as the 'Green Book', available at . This CKS topic covers childhood immunization against infectious diseases, and provides information about vaccines and their benefits. This CKS topic does not cover the treatment of anaphylaxis. It also does not cover the immunization of children with underlying medical conditions — this information can be found in chapter 7 of the PHE publication Immunisation against Infectious Disease , commonly referred to as the 'Green Book (...) immunosuppression has been specifically highlighted as contraindication to the administration of live vaccines in response to a Medicines and Healthcare products Regulatory Agency (MHRA) Drug safety update Live attenuated vaccines: avoid use in those who are clinically immunosuppressed [ ] . May to July 2016 — reviewed. A literature search was conducted in May 2016 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials published since the last revision

2018 NICE Clinical Knowledge Summaries

31. Complementary, Alternative and Traditional Medicine in HIV Care

Contact: rapidresponse@ohtn.on.ca ? While some forms of complementary and alternative medicine do not interact with antiretroviral medications, herbal remedies have the highest potential for contraindications. The highest risk is in countries where complementary and alternative medicine is not regulated and herbal remedies are commonly used (6). While there is a low risk of interactions between complementary and alternative medicine and antiretroviral drugs, there is a potential that herbal (...) irritations, abdominal pain, nausea, diarrhea, pain, quality of sleep, appetite, increasing body weight, depression and other clinical outcomes (5;6). In addition, some findings have suggested that complementary and alternative medicine can assist in the treatment of comorbidities such as osteoporosis and atherosclerosis (1). makokinetic interactions between antiretrovirals and medicinal plants used as complementary and Afri- can tranditional medicines. Bio- pharmaceutics and Drug Disposi- tion 2011;32(8

2013 Ontario HIV Treatment Network

32. A Study of A-101 Solution in Subjects With Common Warts.

in Subjects With Common Warts. Study Start Date : December 21, 2015 Actual Primary Completion Date : September 16, 2016 Actual Study Completion Date : September 16, 2016 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: A-101 Solution 40 A-101 Solution 40% administered once per week Drug: A-101 Solution 40 Experimental: A-101 Solution 45 A-101 Solution 45% administered once per week Drug: A-101 Solution 45 (...) on the trunk or extremities Subject is immune compromised (due to chemotherapy, systemic steroids, genetic immunodeficiency, transplant status, etc.) Subject has a history of Human Immunodeficiency Virus (HIV) infection Subject has had any Human Papilloma Virus (HPV) vaccine within 1 year prior to enrollment Subject has used any of the following intralesional therapies within the specified period prior to enrollment to the Target Wart: Immunotherapy (Candida antigen, mumps antigen, Trichophyton antigen

2016 Clinical Trials

33. A Phase 3 Study to Evaluate the Efficacy and Safety of CLS006 Versus Vehicle in Subjects 2 Years of Age or Older With Cutaneous Common Warts

urine pregnancy test at Screening and Baseline Subjects free of any clinically significant dermatologic disorder in the treatment area Subjects free of any clinically significant systemic condition which will interfere with the study assessments or increase the risk of AEs Subjects willing to refrain from using other topical products in the treatment area, or prohibited medications for the duration of the study Exclusion Criteria: Subjects who have used any wart treatments/therapies, prescription (...) with immunotherapy (DPCP, DNCB or other), imiquimod, 5-fluorouracil,bleomycin, podophyllin or any other wart immunotherapy or treatment (e.g., Candida antigen) designed to stimulate immune response within 12 weeks of the Baseline Visit. Subjects who are immunocompromised. Subjects who have taken, within 30 days prior to the Baseline visit, or require treatment with systemic immunosuppressive or immunomodulatory medication (including oral or parenteral corticosteroids) during the course of the study Subjects who

2016 Clinical Trials

34. Warts and verrucae

( 2012 ) Plantar warts (verrucas). British Association of Dermatologists. . [ ] BNF 68 (2014) British National Formulary. 68th edn. London: British Medical Association and Royal Pharmaceutical Society of Great Britain. British Swimming, ASA ( 2014 ) Understanding verrucas. swimming.org. British Swimming & Amateur Swimming Association. . [ ] Bruggink,S., Eekhof,J., Egberts,P., et al. ( 2013 ) Natural course of cutaneous warts among primary schoolchildren: a prospective cohort study. Annals of Family (...) is painful, cosmetically unsightly, persistent, or the person requests treatment. For the treatment of other warts in adults and older children, options are topical salicylic acid, cryotherapy, or a combination of both (cryotherapy is not recommended for younger children). Warts can generally be managed in primary care, but referral to a dermatologist is necessary if the person has: An uncertain diagnosis. A facial wart. Multiple recalcitrant warts and compromised immunity. Extensive warts. Persistent

2014 NICE Clinical Knowledge Summaries

35. Study of Leukocyte Interleukin, Injection for Treatment of Perianal Warts

to scheduled Pap smears Exclusion Criteria: Anal cancer (current or history of) Inability to attend study visits Participation in any other drug study History of asthma History of CHF and/or cardiac support for arrhythmia or on chronic cardiac medication or has other chronic or acute cardiac ailments (e.g., or abnormal EKG at Baseline) History of organ transplantation or requiring chronic administration of immune suppressive drugs in the last 6 months For women, neither pregnant nor lactating (...) the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03038828 Locations Layout table for location information United States, California Naval Medical Center San Diego San Diego, California, United States, 92134-5000 University of California San Francisco San Francisco, California, United States, 94115

2016 Clinical Trials

36. Effectiveness Study of Human Papilloma Virus (HPV) Vaccines to Prevent Recurrence of Genital Warts

Recruitment Status : Recruiting First Posted : April 25, 2016 Last Update Posted : October 29, 2018 See Sponsor: University of Pretoria Collaborator: University of Stellenbosch Information provided by (Responsible Party): Professor Greta Dreyer, University of Pretoria Study Details Study Description Go to Brief Summary: Large genital warts are frequently diagnosed in general gynaecology and oncology clinics in South Africa. Medical and destructive therapy for small warts is generally very effective (...) Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Participant) Primary Purpose: Prevention Official Title: Prophylactic Vaccines as Therapy: Prevention of Recurrence of Extensive Genital Warts Actual Study Start Date : July 1, 2018 Estimated Primary Completion Date : June 2019 Estimated Study Completion Date : July 2020 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Active Comparator

2016 Clinical Trials

37. Pharmacodynamics, Safety and Efficacy of Topical Omiganan in Patients With External Genital Warts

to screening. Use of active treatment (i.e. cryotherapy, laser therapy, topical medication and/or surgical treatments) for genital warts within 28 days prior to first study drug administration. Immunosuppressed patients, having an immunodeficiency (primary or secondary, like HIV) or receiving immunosuppressive therapy (i.e. Transplant patients). Males or Females who received a vaccination with Gardasil or Cervarix. Any (medical) condition that would, in the opinion of the Investigator, potentially (...) : Cutanea Life Sciences, Inc. Collaborator: Leiden University Medical Center Information provided by (Responsible Party): Cutanea Life Sciences, Inc. Study Details Study Description Go to Brief Summary: The purpose of this study is to assess the pharmacodynamics, safety and efficacy of omiganan in patients with external genital warts. Condition or disease Intervention/treatment Phase Condylomata Acuminata (External) Drug: Omiganan (CLS001) topical gel Drug: Vehicle topical gel Phase 2 Study Design Go

2016 Clinical Trials

38. Active-Controlled Study to Assess the Efficacy and Safety of DFD-05 in Subjects With Common Warts

: Dr. Reddys Laboratories, SA Information provided by (Responsible Party): Dr. Reddys Laboratories, SA Study Details Study Description Go to Brief Summary: DFD05 vs. Active01 in the treatment of common warts Condition or disease Intervention/treatment Phase Common Warts Drug: DFD05 Cream Drug: Active01 Cream Phase 2 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 50 participants Allocation: Randomized Intervention Model (...) : Parallel Assignment Masking: Double (Participant, Investigator) Primary Purpose: Treatment Study Start Date : January 2016 Actual Primary Completion Date : May 2016 Actual Study Completion Date : August 2016 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: DFD05 Cream DFD05 Cream Drug: DFD05 Cream Active Comparator: Active01 Cream Active01 Cream Drug: Active01 Cream Outcome Measures Go to Primary Outcome

2016 Clinical Trials

39. Risk factors for recurrence after successful treatment of warts: the role of smoking habits. (Abstract)

Risk factors for recurrence after successful treatment of warts: the role of smoking habits. Several therapies have been proposed for cutaneous warts without results concerning factors affecting recurrences.To determine the importance of individual characteristics and different therapy modalities in the occurrence of relapses.Observational prospective cohort study including 199 patients affected by multiple plantar warts treated as follows: 49 with keratolytics, 50 with CO2 laser, 50 (...) with pulsed dye laser (PDL) and 50 with cryotherapy. Personal data were evaluated through a questionnaire, and treatment information was collected. A Cox regression analysis was performed to identify independent factors for relapse occurrence.Of patients, 57.8% showed a persistent clearance of warts after treatment with a higher recurrence-free interval when treated with PDL. Accordingly, the risk of recurrence was increased with CO2 laser [hazard ratio (HR) 2.92, 95% confidence interval (CI) 1.49-5.74

2016 Journal of the European Academy of Dermatology and Venereology

40. Fractional Laser-Assisted Topical Imiquimod 5% Cream Treatment for Recalcitrant Common Warts in Children: A Pilot Study. (Abstract)

Fractional Laser-Assisted Topical Imiquimod 5% Cream Treatment for Recalcitrant Common Warts in Children: A Pilot Study. Conventional treatments for warts like cryotherapy are limited by the pain during procedures, especially in pediatric patients. Imiquimod is a topical immune response modifier, but the thick stratum corneum of common warts prevents drug permeation through skin.To evaluate the efficacy and safety of fractional laser/topical 5% imiquimod cream for the treatment of warts (...) in children.Eleven pediatric patients with multiple recalcitrant common warts were included. Lesions were treated using an ablative fractional 2,940-nm Er:YAG laser at 1- or 2-week interval. After each laser treatment session, imiquimod 5% cream was self-applied once daily 5 days a week. Response and adverse effects were assessed 2 weekly until complete clearance or up to maximum of 48 weeks. Pain during fractional laser was assessed using a visual analogue scale (0-10).Eight of the 11 (72.7%) children

2016 Dermatologic Surgery

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