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Wart Treatment

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1. Oral cimetidine as the treatment of common warts

Oral cimetidine as the treatment of common warts Oral cimetidine as the treatment of common warts – Morsels of Evidence \t\t\t\r\n\t\t\t \t\t\t\r\n\t\t\t Like this: Like Loading... ","author":{"@type":"Person","name":"Michael Tam"},"image":["https:\/\/evidencebasedmedicine.com.au\/wp-content\/uploads\/2019\/01\/MO-DecJan2019cover.png"]} Toggle search form Toggle navigation Evidence-based medicine for general practitioners Jan 07 2019 Oral cimetidine as the treatment of common warts (...) By in , Journal reference: Yilmaz E, Alpsoy E, Basaran E. Cimetidine therapy for warts: a placebo-controlled, double-blind study. J Am Acad Dermatol 1996 Jun;34(6):1005-7 Link: Published: June 1996 Evidence cookie says… The limited research evidence does not support the use of oral cimetidine as the treatment of common warts anecdotal evidence of major benefits are not seen in blinded randomised trials although cimetidine is often seen as benign, side-effects were reported in a fifth of participants in one

2019 Morsels of Evidence

2. A commonly used surface treatment is the most suitable first-line treatment for genital warts

A commonly used surface treatment is the most suitable first-line treatment for genital warts A commonly used surface treatment is the most suitable first-line treatment for genital warts Discover Portal Discover Portal A commonly used surface treatment is the most suitable first-line treatment for genital warts Published on 2 August 2016 doi: Podophyllotoxin 0.5% solution followed by carbon dioxide laser therapy only if unsuccessful may be the best treatment approach for anal and genital warts (...) . Either of these treatments can successfully clear warts in over three quarters of people. The podophyllotoxin 0.5% solution can be applied to the warts twice a day for three days at home. Further courses can be applied if necessary after a break of four days. Alternatively, carbon dioxide laser therapy is performed under local or general anaesthetic. Soreness and irritation is common after laser therapy but it is effective and also more useful for warts in less accessible places. The results

2019 NIHR Dissemination Centre

3. Imiquimod for the Treatment of Genital Warts: A Review of Clinical Effectiveness and Cost-Effectiveness

Imiquimod for the Treatment of Genital Warts: A Review of Clinical Effectiveness and Cost-Effectiveness Imiquimod for the Treatment of Genital Warts: A Review of Clinical Effectiveness and Cost-Effectiveness | CADTH.ca Find the information you need Imiquimod for the Treatment of Genital Warts: A Review of Clinical Effectiveness and Cost-Effectiveness Imiquimod for the Treatment of Genital Warts: A Review of Clinical Effectiveness and Cost-Effectiveness Published on: September 25, 2017 Project (...) Number: RC0930-000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of imiquimod for the treatment of genital warts? What is the cost-effectiveness of imiquimod for the treatment of genital warts? Key Message Evidence from systematic reviews with low quality included studies suggests that overall for patients with anogenital warts (AGW) compared to placebo, treatment with imiquimod (IMQ) is associated

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

4. A commonly used surface treatment is the most suitable first-line treatment for genital warts

A commonly used surface treatment is the most suitable first-line treatment for genital warts A commonly used surface treatment is the most suitable first-line treatment for genital warts Discover Portal Discover Portal A commonly used surface treatment is the most suitable first-line treatment for genital warts Published on 2 August 2016 doi: Podophyllotoxin 0.5% solution followed by carbon dioxide laser therapy only if unsuccessful may be the best treatment approach for anal and genital warts (...) . Either of these treatments can successfully clear warts in over three quarters of people. The podophyllotoxin 0.5% solution can be applied to the warts twice a day for three days at home. Further courses can be applied if necessary after a break of four days. Alternatively, carbon dioxide laser therapy is performed under local or general anaesthetic. Soreness and irritation is common after laser therapy but it is effective and also more useful for warts in less accessible places. The results

2018 NIHR Dissemination Centre

5. Genital warts

Genital warts Genital warts - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Genital warts Last reviewed: February 2019 Last updated: February 2019 Summary Very common STI. Caused by human papillomavirus (HPV) infection, most commonly HPV types 6 and 11. Peak incidence of genital HPV infection occurs in 16- to 25-year-olds. Diagnosis is made based on clinical presentation. Generally has a benign course (...) and is not often associated with oncogenic potential. Treatment can be challenging, as there is no cure and recurrences are common. Definition Genital warts are the most prevalent form of viral genital mucosal lesions and are caused by infection with several types of human papillomavirus (HPV). Mansur CP. Human papillomaviruses. In: Tyring SK, ed. Mucocutaneous manifestations of viral diseases. New York, NY: Marcel Dekker; 2002:247-94. The infection manifests as verrucous fleshy papules that may coalesce

2019 BMJ Best Practice

6. Genital warts

Genital warts Genital warts - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Genital warts Last reviewed: February 2019 Last updated: February 2019 Summary Very common STI. Caused by human papillomavirus (HPV) infection, most commonly HPV types 6 and 11. Peak incidence of genital HPV infection occurs in 16- to 25-year-olds. Diagnosis is made based on clinical presentation. Generally has a benign course (...) and is not often associated with oncogenic potential. Treatment can be challenging, as there is no cure and recurrences are common. Definition Genital warts are the most prevalent form of viral genital mucosal lesions and are caused by infection with several types of human papillomavirus (HPV). Mansur CP. Human papillomaviruses. In: Tyring SK, ed. Mucocutaneous manifestations of viral diseases. New York, NY: Marcel Dekker; 2002:247-94. The infection manifests as verrucous fleshy papules that may coalesce

2018 BMJ Best Practice

7. Common warts

Common warts Common warts - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Common warts Last reviewed: February 2019 Last updated: January 2018 Summary Common warts, also known as verrucae vulgaris, are caused by HPV infection and affect most people during their lifetimes. They are most common in children and young adults. Common warts should be distinguished from serious conditions that mimic them, such as squamous (...) cell carcinoma, especially in immunocompromised patients. The goals of treatment are to destroy the lesion, induce cytotoxicity against infected cells, and promote antiviral immunoresponsiveness to prevent recurrence. Best outcomes are achieved with a combination of destructive and immunosensitising approaches. Most common warts in healthy people resolve spontaneously. Clearance rates in children from time of diagnosis to clearance are 23% at 2 months, 30% at 3 months, 65% to 78% at 2 years, and 90

2018 BMJ Best Practice

8. Green tea leaf extract (Veregen) - an aggressive topical treatment for anogenital warts

Green tea leaf extract (Veregen) - an aggressive topical treatment for anogenital warts Prescrire IN ENGLISH - Spotlight ''In the April issue of Prescrire International: Green tea leaf extract (Veregen°) - an aggressive topical treatment for anogenital warts'', 1 April 2015 {1} {1} {1} | | > > > In the April issue of Prescrire International: Green tea leaf extract (Veregen°) - an aggressive topical treatment for anogenital warts Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 (...) most recent :  |   |   |   |   |   |   |   |   |  Spotlight In the April issue of Prescrire International: Green tea leaf extract (Veregen°) - an aggressive topical treatment for anogenital warts FREE DOWNLOAD In this sample page from the New Products section: while drugs obtained from plants have the reputation of being innocuous, they sometimes provoke serious adverse effects. Full text available for free download. Summary

2015 Prescrire

9. Topical treatments for external genital warts in non-immunocompromised patients: a systematic review and network meta-analysis

Topical treatments for external genital warts in non-immunocompromised patients: a systematic review and network meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any (...) , this assumption is unlikely to hold true for data from animal studies, which generally include various species, strains and treatment regimes, for which different true effects are likely to exist. The random-effects model takes into account both the within-study (sampling error) and between-study (differences in the true effect size) variance. Should the excessive between-study variance be very low or zero, the random-effects model will yield the same results as the fixed-effect model. For further details

2019 PROSPERO

10. Efficacy of bleomycin application on periungual warts after treatment with ablative carbon dioxide fractional laser: a pilot study. (PubMed)

Efficacy of bleomycin application on periungual warts after treatment with ablative carbon dioxide fractional laser: a pilot study. Treating periungual warts is a therapeutic challenge. Treatments are often ineffective and may cause complications including permanent nail changes, pain, and scaring. Translesional bleomycin delivery via the multipuncture technique is now reported.To investigate the efficacy and safety of bleomycin solution (1 U/mL) after ablative fractional carbon dioxide (CO2 (...) ) laser for treating periungual warts.Warts were treated with ablative CO2 fractional laser, after which bleomycin was applied. Patients were treated every 2 weeks until the lesions disappeared. Treatment was discontinued if adverse events occurred or the patient wanted to stop.Seventeen patients (11 women, mean age 16.23 years) with a total of 38 warts were enrolled from May 2017 to Aug 2018. Twenty-six lesions (68.4%) achieved complete clearance; three (7.8%) had excellent partial response (>75

2019 Journal of Dermatological Treatment

11. Duct tape to treat cutaneous warts

, Holland R, Abbott R. Topical treatments for cutaneous warts. Cochrane database of systematic reviews 2012 Sep 12(9):CD001781 Link: Published: September 2012 Evidence cookie says… Duct tape should not be routinely recommended as wart therapy. There is no compelling evidence that duct tape is more effective than placebo. Clinical scenario Krystal, a 21-year-old office worker saw me recently with common warts on her hand. She mentioned that her mother had suggested that she use duct tape. I recalled (...) that in a recent discussion on the online group GPs Down Under , duct tape had its advocates. What is the evidence? Clinical question What is the effect of applying duct tape as treatment on the recovery of common warts? What does the research evidence say? Step 1: The Cochrane Library The Cochrane Library has a systematic review that is update-to-date to May 2011 on topical treatments for warts, including duct tape [1]. Step 2: TripDatabase & PubMed I conducted a search using the TripDatabase PICO search tool

2017 Morsels of Evidence

12. Duct tape to treat cutaneous warts

, Holland R, Abbott R. Topical treatments for cutaneous warts. Cochrane database of systematic reviews 2012 Sep 12(9):CD001781 Link: Published: September 2012 Evidence cookie says… Duct tape should not be routinely recommended as wart therapy. There is no compelling evidence that duct tape is more effective than placebo. Clinical scenario Krystal, a 21-year-old office worker saw me recently with common warts on her hand. She mentioned that her mother had suggested that she use duct tape. I recalled (...) that in a recent discussion on the online group GPs Down Under , duct tape had its advocates. What is the evidence? Clinical question What is the effect of applying duct tape as treatment on the recovery of common warts? What does the research evidence say? Step 1: The Cochrane Library The Cochrane Library has a systematic review that is update-to-date to May 2011 on topical treatments for warts, including duct tape [1]. Step 2: TripDatabase & PubMed I conducted a search using the TripDatabase PICO search tool

2017 Morsels of Evidence

13. Imiquimod for the Treatment of External Genital Warts in Adults: Clinical and Cost-effectiveness

Imiquimod for the Treatment of External Genital Warts in Adults: Clinical and Cost-effectiveness Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time allowed. Rapid (...) of External Genital Warts in Adults: Clinical and Cost-effectiveness DATE: 07 December 2012 RESEARCH QUESTIONS 1. What is the clinical evidence of the benefits and harms of 5% imiquimod for the treatment of external genital warts? 2. What is the evidence of the cost-effectiveness of 5% imiquimod for the treatment of external genital warts KEY MESSAGE One systematic review, two meta-analyses, three randomized controlled trials, three non- randomized studies, and two economic evaluations were identified

2013 Canadian Agency for Drugs and Technologies in Health - Rapid Review

14. A Phase 2 Controlled Study of SB206, a Topical Nitric Oxide-Releasing Drug for Extragenital Wart Treatment. (PubMed)

A Phase 2 Controlled Study of SB206, a Topical Nitric Oxide-Releasing Drug for Extragenital Wart Treatment. Nitric oxide (NO), a free radical gas, is endogenously produced in human cells. In high concentration, NO neutralizes many disease-causing microbes. The topical investigational drug SB206 releases NO and has the potential to treat skin diseases caused by viruses. Genital warts (condyloma acuminata) are primarily caused by human papillomavirus (HPV) types 6 and 11. Available treatments (...) have low tolerability and efficacy rates and are inconvenient for the patient. Genital warts can recur if HPV is incompletely eradicated during treatment.Topical SB206 (berdazimer sodium plus carboxymethyl cellulose hydrogel) was assessed for tolerability, safety, and efficacy for up to12 weeks in patients with external genital and/or perianal warts (EGW/PAW) in a phase 2, double-blind, randomized, dose-escalation study.Patients (N=108) were randomly assigned to SB206 or vehicle in a 3:1 ratio

2018 Journal of drugs in dermatology : JDD

15. Efficacy of a bleomycin microneedle patch for the treatment of warts. (PubMed)

Efficacy of a bleomycin microneedle patch for the treatment of warts. Warts are a common skin disease caused by infection of the human papilloma virus. Most treatments involving physical destruction of the infected cells, such as cryotherapy and electrocautery, are limited by intense pain, failure, or recurrences. Our aim was to compare the therapeutic effects of a newly developed bleomycin microneedle patch with cryotherapy in the treatment of warts. Forty-two patients with more than two wart (...) lesions were included in the study. The two treatment modalities were randomly applied to different warts on each patient. Treatment efficacy was assessed using the Physician's Global Assessment (PGA) and the Patient's Global Assessment (PaGA). Mean PGA and PaGA scores were not significantly different between cryotherapy and bleomycin microneedle patch treatment. It was also determined that the mean size of all the warts treated with either modality shrank about equally at weeks 8 and 16 after initial

2018 Drug delivery and translational research

16. Comparison of clinical efficacy and safety of thermotherapy versus cryotherapy in treatment of skin warts: A randomized controlled trial. (PubMed)

Comparison of clinical efficacy and safety of thermotherapy versus cryotherapy in treatment of skin warts: A randomized controlled trial. The effect of thermotherapy in the treatment of skin warts in comparison to cryotherapy, as the standard conventional method, has remained uncertain. This study aimed to assess the clinical efficacy and safety of thermotherapy and cryotherapy in removing skin warts. This randomized controlled trial was conducted on 52 patients aged 18 years and over with ≤ 10 (...) skin warts. The participants were randomly assigned into two groups to receive cryotherapy (every 2 to 3 weeks up to six sessions if required) or thermotherapy (one session). The patients in both groups were followed every 2 to 3 weeks for the first three months, and then three months after the last treatment session. The clearance rate was 79.2% in the thermotherapy group and 58.3% in the cryotherapy group with no significant difference (p = 0.212). The rate of scarring in the thermotherapy group

2018 Dermatologic therapy

17. Treatment of Multiple-Resistant and/or Recurrent Cutaneous Warts With Squaric Acid Dibutylester: A Randomized, Double-blind, Vehicle-controlled Clinical Trial. (PubMed)

Treatment of Multiple-Resistant and/or Recurrent Cutaneous Warts With Squaric Acid Dibutylester: A Randomized, Double-blind, Vehicle-controlled Clinical Trial. Contact immunotherapy with squaric acid dibutylester (SADBE) for cutaneous warts has been reported to be effective, although no controlled studies are available so far.The aim of this study was to evaluate the efficacy of SADBE on cutaneous warts by a randomized, double-blind, vehicle-controlled, clinical trial.Thirty-six patients were (...) randomly assigned to SADBE (18 cases) or vehicle (18 cases) group. At 8 weeks, subjects were clinically evaluated for number/size reduction rate and for Investigator Global Assessment. Those who showed improvement extended therapy up to 40 weeks, whereas those who showed unresponsiveness were either switched to SADBE application for up to 48 weeks (if in the vehicle group) or withdrawn from the study (if under SADBE).At 8 weeks, a significant reduction in wart number (P = 0.020) and size (P = 0.010

2018 Dermatitis : contact, atopic, occupational, drug

18. Cryotherapy versus CO2 laser in the treatment of plantar warts: a randomized controlled trial (PubMed)

Cryotherapy versus CO2 laser in the treatment of plantar warts: a randomized controlled trial Warts are one of the most common infections in humans. Plantar warts are a subtype of non-genital warts, and several procedures and topical treatments have been used in its treatment. Cryotherapy is one of the most popular modalities, but it is time-consuming and remission rates vary in different studies. CO2 laser was the first laser used for treating warts. To date, no clinical trial has been done (...) to compare CO2 laser with cryotherapy in the treatment of plantar warts.This randomized controlled trial was performed in order to compare the efficacy and number of sessions needed to treat plantar warts in 60 patients who had received no previous treatment in the previous 3 months. They were randomly allocated to the cryotherapy or CO2 laser group. The number of sessions needed for response and the recurrence rate after a 3-month follow-up was compared in the 2 groups.Sixty patients with plantar warts

Full Text available with Trip Pro

2018 Dermatology practical & conceptual

19. Time-lapse imaging points towards a non-toxic, mainly immune-driven mode of action of ingenol mebutate in the treatment of anogenital warts. (PubMed)

Time-lapse imaging points towards a non-toxic, mainly immune-driven mode of action of ingenol mebutate in the treatment of anogenital warts. Recently, it has been reported that ingenol mebutate (IM) is an effective treatment option for anogenital warts (AGW), inducing fast wart necrosis within 24 hours in vivo. With regard to its mode of action, IM is thought to act both as an inducer of direct cytotoxic effects and immunologic mechanisms. To distinguish whether the wart necrosis is mainly (...) caused by cytotoxic effects, or whether immune mechanisms are leading, we used time-lapse imaging to analyse IM-treated warts ex vivo over 24 hours. Ex vivo IM-treated warts, which have been detached from the immune system, did not show destructive necrosis, pointing towards a primarily immune-driven mode of action of IM in the treatment of AGW.© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

2018 Experimental Dermatology

20. Study of A-101 Topical Solution for the Treatment of Common Warts

Study of A-101 Topical Solution for the Treatment of Common Warts Study of A-101 Topical Solution for the Treatment of Common Warts - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Study of A-101 Topical (...) Solution for the Treatment of Common Warts The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03687372 Recruitment Status : Recruiting First Posted : September 27, 2018 Last Update Posted : March 26, 2019 See Sponsor: Aclaris

2018 Clinical Trials

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