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Vulvodynia

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2. Patterns in Vulvodynia Treatments and 6-Month Outcomes for Women Enrolled in the National Vulvodynia Registry-An Exploratory Prospective Study. (PubMed)

Patterns in Vulvodynia Treatments and 6-Month Outcomes for Women Enrolled in the National Vulvodynia Registry-An Exploratory Prospective Study. Vulvodynia is a poorly characterized condition with multiple treatment options that have been described as largely ineffective in research settings.To describe treatment patterns in women enrolled in the National Vulvodynia Registry and determine if there is an association between selected treatments and patient-reported outcomes such as pain, sexual (...) and long-term study design that evaluated women in clinical settings. Limitations include a high rate of loss to follow-up for certain measures and inability to evaluate efficacy of individual treatments. In a setting where women were receiving highly specialized care, we found wide variation in the type and number of treatments used to treat vulvodynia. Despite this heterogeneity in treatment selection, women reported significant improvements in all study measures except sexual function. Lamvu G

2018 Journal Of Sexual Medicine

3. Vulvodynia is not created equally: empirical classification of women with vulvodynia (PubMed)

Vulvodynia is not created equally: empirical classification of women with vulvodynia Vulvodynia classification is based on the sensory dimensions of pain and does not include psychological factors associated with the pain experience and treatment outcomes. Previous work has shown that individuals with chronic pain can be classified into subgroups based on pain sensitivity, psychological distress, mood, and symptom severity.The aim of this study was to identify distinct subgroups of women (...) with vulvodynia enrolled in the National Vulvodynia Registry. We hypothesized that women with vulvodynia can be clustered into subgroups based on distress and pain sensitivity.A cross-sectional study.We conducted an exploratory hierarchical agglomerative cluster analysis using Ward's cluster method and squared Euclidean distances to identify unique subgroups based on baseline psychological distress and pain sensitivity. The variables included the catastrophizing subscale of the Coping Strategies Questionnaire

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2017 Journal of pain research

4. The Evidence-based Vulvodynia Assessment Project. A National Registry for the Study of Vulvodynia. (PubMed)

The Evidence-based Vulvodynia Assessment Project. A National Registry for the Study of Vulvodynia. To create a national registry for the study of vulvodynia in order to enhance classification of vulvodynia based on multiple phenotypic domains such as pain characteristics, clinical examination, sexual function, psychological functioning, and distress.Methodology for this prospective cohort registry was institutional review board approved and implemented at 8 enrollment sites starting in 2009 (...) . The most common pain comorbidities reported by the women were migraines (34%), chronic pelvic pain (22%), and irritable bowel syndrome (20%). Anxiety affected 41% of the cohort. More than 90% presented with localized vestibular pain, and 90% had muscular examination abnormalities.A national registry for the study of vulvodynia was established with successful enrollment of participants at 8 sites. In addition to the cotton swab evaluation for vulvar allodynia, women with vulvar chronic pain should also

2017 Journal of Reproductive Medicine

5. Effectiveness of a Multidisciplinary Approach to Dyspareunia in Women with Vulvodynia

Effectiveness of a Multidisciplinary Approach to Dyspareunia in Women with Vulvodynia "Effectiveness of a Multidisciplinary Approach to Dyspareunia in Women " by Cloe Dedman and Philease Martin < > > > > > Title Author Date of Graduation Summer 8-12-2017 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies Rights . Abstract Abstract Background: Vulvodynia is a multifactorial pain disorder characterized by vulvar pain, irritation, and dyspareunia resulting (...) in physical, sexual, and psychological distress. The symptoms that women experience have a significant impact not only on their sexual functioning but also on their psychological well-being and overall quality of life. Currently there is no consensus among health care providers on the approach or treatment strategies for vulvodynia. This systematic review examines whether the use of a multidisciplinary approach can be a more effective treatment of dyspareunia in women with provoked vestibulodynia (PVD

2017 Pacific University EBM Capstone Project

6. A systematic review of drug treatment of vulvodynia: evidence of a strong placebo effect

A systematic review of drug treatment of vulvodynia: evidence of a strong placebo effect Vulvodynia is the most common type of chronic pelvic pain and dyspareunia in premenopausal women. The effect of drugs for the treatment of vulvodynia remains poorly discussed.To conduct a systematic review of randomised controlled studies which assess medications used to treat vulvar pain in vulvodynia.Web of Science, Cochrane Library, EBSCO Academic, LILACS and MEDLINE were searched from 1985 to September (...) 2016.Randomised controlled trials comparing any kind of medication for vulvodynia treatment with placebo or with another medication in adult patients were included.The two investigators independently conducted data extraction. The synthesis was provided by the pain reduction index. Study quality assessment was performed using the Cochrane Handbook for Systematic Reviews of Intervention and analysis of publication bias was conducted.Five studies were included in qualitative synthesis. Number

2018 EvidenceUpdates

7. Effectiveness of therapies for the treatment of vulvodynia: a systematic review

Effectiveness of therapies for the treatment of vulvodynia: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email

2019 PROSPERO

8. Altered Gray Matter Volume in Sensorimotor and Thalamic Regions associated with Pain in Localized Provoked Vulvodynia: A Voxel-based Morphometry Study. (PubMed)

Altered Gray Matter Volume in Sensorimotor and Thalamic Regions associated with Pain in Localized Provoked Vulvodynia: A Voxel-based Morphometry Study. Multimodal neuroimaging studies provide support for a role of alterations in sensory processing circuits and endogenous pain modulatory systems in provoked vestibulodynia (PVD). In this study we tested the hypotheses that PVD compared to healthy controls (HCs) would demonstrate gray matter volume (GMV) alterations in regions associated

2019 Pain

9. Mindfulness-Based Group Cognitive Behavior Therapy for Provoked Localized Vulvodynia: A Randomized Controlled Trial. (PubMed)

Mindfulness-Based Group Cognitive Behavior Therapy for Provoked Localized Vulvodynia: A Randomized Controlled Trial. The aim of the study was to compare the effectiveness of mindfulness-based group cognitive behavior therapy (M-gCBT) versus education support group therapy for the pain and distress associated with provoked localized vulvodynia.Participants were randomized to M-gCBT or education support group therapy. Mindfulness-based group cognitive behavior participants attended 8 weekly (...) in the Female Sexual Function Index, Generalized Anxiety Disorder 7, and Beck's Depression Index compared with the education support group.Mindfulness-based group cognitive behavior and education support group therapy are effective in reducing pain and distress. However, women in the M-gCBT program showed greater improvement in certain secondary outcomes, indicating that M-gCBT may offer some advantages in reducing distress associated with provoked localized vulvodynia.

2019 Journal of lower genital tract disease

10. Early-life Chronic Stressors, Rumination, and the Onset of Vulvodynia. (PubMed)

Early-life Chronic Stressors, Rumination, and the Onset of Vulvodynia. Vulvodynia is a debilitating, chronic vulvar pain condition. Community-based case-control studies have consistently shown associations between early-life chronic stressors and vulvodynia onset.We examined rumination as a specific stress response involved in the psychobiological mechanism of vulvodynia.A psychosocial survey with questions specific to early-life traumatic events and rumination were administered to 185 matched (...) case-control pairs of women with and without vulvodynia. Conditional logistic regression was used to examine associations between rumination constructs (ie, total rumination, emotion-focused, instrumental, and searching for meaning) and vulvodynia onset. Conditional logistic regression was also used to determine whether these associations depended on early-life stressors (ie, severity of childhood abuse and of self-reported antecedent traumatic events). Age at interview, antecedent pain disorders

2019 Journal Of Sexual Medicine

11. Vulvodynia, "A Really Great Torturer": A Mixed Methods Pilot Study Examining Pain Experiences and Drug/Non-drug Pain Relief Strategies. (PubMed)

Vulvodynia, "A Really Great Torturer": A Mixed Methods Pilot Study Examining Pain Experiences and Drug/Non-drug Pain Relief Strategies. Women with vulvodynia, a chronic pain condition, experience vulvar pain and dyspareunia. Few studies examine the range and combination of treatment strategies that women are actually using to reduce vulvodynia.To describe pain experiences and pain relief strategies of women with vulvodynia.Convenience sample, 60 women with vulvodynia (median age 32.5 (...) for patterns.Our mixed methods analysis connected data from pain measures, prescribed treatments and self-reported behaviors with women's free responses. This enabled nuanced insights into women's vulvodynia pain experiences.Women's descriptions of their pain and suffering aligned with their reported severe pain and attempts to control their pain, with a median pain intensity of 6.7 (IQR 2.0) despite use of adjuvant drugs (median 2.0 [IQR 2.0]), and opioids (median 1.0 [IQR 2.0]). 36 women (60%) used alcohol

2019 Journal Of Sexual Medicine

12. Women's appraisal of the management of vulvodynia by their general practitioner: a qualitative study. (PubMed)

Women's appraisal of the management of vulvodynia by their general practitioner: a qualitative study. Provoked Vulvodynia (PVD) is the most common cause of vulvar pain. General practitioners (GPs) are insufficiently familiar with it, causing a delay in many women receiving correct diagnosis and treatment. Besides patients factors, this delay can partly be explained by the reluctance of GPs to explore the sexual context of PVD and by their negative emotional reactions such as helplessness

2019 Family Practice

13. Pain Trajectories and Predictors: A 7-Year Longitudinal Study of Women With Vulvodynia. (PubMed)

Pain Trajectories and Predictors: A 7-Year Longitudinal Study of Women With Vulvodynia. A significant proportion of women report a reduction of symptoms over time-even without treatment-yet the natural progression of vulvodynia and which factors may explain decrease vs persistence of pain remain unclear.To identify subgroups of pain trajectories in women with vulvodynia and to predict these different trajectories by treatments undertaken, pain characteristics, and psychosocial factors.Data (...) on pain intensity, treatments undertaken, pain characteristics, and psychosocial factors were collected 3 times over a 7-year period from 173 women who screened positive for vulvodynia. Latent class growth analysis was conducted to identify homogeneous subgroups with distinct pain trajectories. A multivariate binomial logistic regression was used to examine whether treatments, pain characteristics, and psychosocial factors predicted these trajectories.The main outcome was pain intensity (0-10

2019 Journal Of Sexual Medicine

14. Repeated hapten exposure induces persistent tactile sensitivity in mice modeling localized provoked vulvodynia. (PubMed)

Repeated hapten exposure induces persistent tactile sensitivity in mice modeling localized provoked vulvodynia. Vulvodynia is a remarkably prevalent chronic pain condition of unknown etiology. Epidemiologic studies associate the risk of vulvodynia with a history of atopic disease. We used an established model of hapten-driven contact hypersensitivity to investigate the underlying mechanisms of allergy-provoked prolonged sensitivity to pressure.We sensitized female ND4 Swiss mice to the hapten

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2017 PLoS ONE

15. Fear-avoidance and Pelvic Floor Muscle Function are Associated with Pain Intensity in Women with Vulvodynia. (PubMed)

Fear-avoidance and Pelvic Floor Muscle Function are Associated with Pain Intensity in Women with Vulvodynia. To investigate the association between fear-avoidance variables, pelvic floor muscle (PFM) function, pain intensity in women with provoked vestibulodynia (PVD), as well as the moderator effect of partner support.A sample of 173 women diagnosed with PVD participated in the study. Fear-avoidance variables were assessed with validated self-administered questionnaires: pain catastrophizing

2018 Clinical Journal of Pain

16. Effect of gabapentin on sexual function in vulvodynia: a randomized, placebo-controlled trial. (PubMed)

Effect of gabapentin on sexual function in vulvodynia: a randomized, placebo-controlled trial. Sexual dysfunction is common in women with vulvodynia.The purpose of this study was (1) to evaluate whether extended-release gabapentin is more effective than placebo in improving sexual function in women with provoked vulvodynia and whether there is a relationship between treatment outcome and pelvic pain muscle severity that is evaluated by palpation with standardized applied pressure and (2 (...) ) to evaluate whether sexual function in women with provoked vulvodynia would approach that of control subjects who report no vulvar pain either before or after treatment.As a secondary outcome in a multicenter double-blind, randomized crossover trial, sexual function that was measured by the Female Sexual Function Index was evaluated with gabapentin (1200-3000 mg/d) compared with placebo. Pain-free control subjects, matched by age and race, also completed Female Sexual Function Index for comparison.From

2018 American Journal of Obstetrics and Gynecology

17. Vulvodynia Drug Research: Heterogeneity In, Uncertainty Out. (PubMed)

Vulvodynia Drug Research: Heterogeneity In, Uncertainty Out. 29603845 2019 02 28 2019 02 28 1471-0528 125 10 2018 09 BJOG : an international journal of obstetrics and gynaecology BJOG Vulvodynia drug research: heterogeneity in, uncertainty out. 1225 10.1111/1471-0528.15229 Witkin S S SS Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynaecology, Weill Cornell Medicine, New York, NY, USA. eng Journal Article Comment 2018 05 16 England BJOG 100935741 1470-0328 AIM IM (...) BJOG. 2018 Sep;125(10):1216-1224 29569822 Female Humans Placebo Effect Uncertainty Vulvodynia 2018 4 1 6 0 2019 3 1 6 0 2018 4 1 6 0 ppublish 29603845 10.1111/1471-0528.15229

2018 BJOG

18. Diagnosis and management of vulvodynia in postmenopausal women. (PubMed)

Diagnosis and management of vulvodynia in postmenopausal women. Vulvodynia, defined as vulvar pain or burning sensation for more than 3 months, without an identifiable cause, can occur at any age. In this paper, the authors address the classification, epidemiology, etiology, diagnosis, and treatment of this condition, focusing on postmenopausal women. In postmenopausal women, vulvar pain and dyspareunia can often be attributed to low levels of estrogen resulting in vulvovaginal atrophy. While (...) correction of vulvovaginal atrophy is an important part of the management of these patients, it will usually be insufficient to manage vulvodynia. The treatment of vulvodynia includes general care measures, topical, oral, or injectable agents, psychological approaches, pelvic floor rehabilitation and, in some cases, surgery. No particular intervention has been shown to be superior, so a "trial and error" strategy is usually used.Copyright © 2017 Elsevier B.V. All rights reserved.

2018 Maturitas

19. Early experience with topical meloxicam and lidocaine combination for the treatment of vulvodynia (PubMed)

Early experience with topical meloxicam and lidocaine combination for the treatment of vulvodynia We report our early clinical observations on the use of topical meloxicam and lidocaine gel for patients with vulvodynia.This is an early experience in participants with a history of vulvodynia evaluated and treated at the Queen's University Pelvic and Bladder Pain Clinic. Combination meloxicam 0.3% and lidocaine 5% were provided to the participants and they were instructed to apply 5 cc (...) - and four-point reductions on the Likert pain scale and mild to moderate improvement of symptoms. Common side effects reported were burning and stinging.The results from this early experience are promising for a potentially effective topical treatment for vulvodynia.

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2018 Canadian Urological Association Journal

20. Facilitators and barriers in the diagnostic process of vulvovaginal complaints (vulvodynia) in general practice: a qualitative study (PubMed)

Facilitators and barriers in the diagnostic process of vulvovaginal complaints (vulvodynia) in general practice: a qualitative study The gap between the relatively high prevalence of provoked vulvodynia (PVD) in the general population and the low incidence in primary care can partly be explained by physicians' lack of knowledge about the assessment and management of PVD.To recognize barriers and facilitators of GPs in the diagnostic process of women presenting with recurrent vulvovaginal

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2018 The European journal of general practice

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