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Vulvar Anatomy

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81. Assessing the Disintegration, Safety, and Acceptability of Placebo Vaginal Inserts for the Delivery of Vaginal Products

product use as required in the protocol Vaginal and cervical anatomy that, in the opinion of the investigator, lends itself to easy examination Willing to give voluntary consent, sign an informed consent form and comply with study procedures as required by the protocol Exclusion Criteria: History of hysterectomy Currently pregnant or within two calendar months from the last pregnancy outcome. Note: If recently pregnant must have had at least two spontaneous menses since pregnancy outcome Use of any (...) vulvar or vaginal symptoms (pain, irritation, spotting, etc.) Known current drug or alcohol abuse which could impact study compliance Participation in any other investigational trial (device, drug, or vaginal trial) within the last 30 days or planned participation in any other investigational trial during the study History of gynecological procedures (including genital piercing) on the external genitalia, vagina or cervix within the last 14 days Abnormal finding on physical examination or a social

2015 Clinical Trials

82. Sentinel Lymph Node Detection in Endometrial Cancer

patients with nodal metastases, diminish side effects caused by full lymphadenectomy and render some expensive preoperative risk group allocation measures unnecessary. A clinically useful SLN technique requires a high technical success rate, a clear definition of SLN, an algorithm taking into account that metastatic nodes not always accumulate tracer and a reproducible surgical algorithm. A definition of SLN requires knowledge on lymphatic anatomy. Unfortunately all tracers, dyes/radiotracers often (...) is to systematically display the major anatomical pathways with the use of ICG and to evaluate a standardized and reproducible SLN surgical algorithm based on lymphatic anatomy and identification of efferent lymph vessels. Condition or disease Intervention/treatment Phase Endometrial Neoplasms Procedure: Sentinel node procedure Not Applicable Detailed Description: Endometrial cancer is an increasingly common gynecologic malignancy. The cumulative 5-year survival rate for node negative patients is 94%, 75% in those

2015 Clinical Trials

83. Survey of male perceptions regarding the vulva. (Abstract)

Survey of male perceptions regarding the vulva. The purpose of this study was to characterize male preferences of vulvar appearance, their awareness of labiaplasty, and their knowledge of genital anatomy.Men 18-80 years old were recruited via emails sent by an Internet provider to participate in a 27-question web-based survey. The questionnaire included images and queried demographics, men's familiarity with vulvar anatomy, preferences regarding labial appearance, and awareness of labiaplasty (...) %), married (68%), employed (69%), and had completed high school or beyond (97%). One-third of the respondents lived in the South, with the other regions nearly equally represented. A significant majority, 95%, reported having been sexually active with women, and 86% felt comfortable labeling the vulvar anatomy. With regard to preferences, more respondents considered smaller labia attractive compared to large labia; yet 36% of the men remained neutral. Men also showed a preference for partially

2015 American Journal of Obstetrics and Gynecology

84. Lymphedema

for cancer patients because of its relatively high frequency and significant functional and quality of life implications for patients. Lymphedema is an independent predictor of decreased quality of life, even when other predictive factors such as socioeconomic status, decreased range of motion, age, and obesity are taken into account.[ ] This summary will review issues related to anatomy and pathophysiology of lymphedema related to cancer, its clinical manifestations, diagnosis, and treatment. Primary (...) (congenital) lymphedema and non–cancer-related lymphedema (e.g., recurrent cellulitis, connective tissue disease, and infection) will not be reviewed here. In this summary, unless otherwise stated, evidence and practice issues as they relate to adults are discussed. The evidence and application to practice related to children may differ significantly from information related to adults. When specific information about the care of children is available, it is summarized under its own heading. Anatomy

2012 PDQ - NCI's Comprehensive Cancer Database

85. Cervical Cancer

live in regions with inadequate screening protocols. Incidence and Mortality Estimated new cases and deaths from cervical (uterine cervix) cancer in the United States in 2019:[ ] New cases: 13,170. Deaths: 4,250. Anatomy The uterine cervix is contiguous with the uterine body, and it acts as the opening to the body of the uterus. The uterine cervix is a cylindrical, fibrous organ that is an average of 3 to 4 cm in length. The portio of the cervix is the part of the cervix that is visible on vaginal

2012 PDQ - NCI's Comprehensive Cancer Database

86. Research Reporting Standards for Endovascular Treatment of Pelvic Venous Insufficiency

in the lower pelvis, vulvar region, and upper thighs. The pain is typicallyexacerbatedwithmensesand may be associated with dyspareunia and prolonged postcoital discomfort. Symptoms are generally most severe at the end of the day and are dimin- ished with supine positioning (24). PVI refers specifically to the patho- physiologyofretrogradeflowthrough incompetentgonadalandpelvicveins. The etiology of PVI is multifactorial, andincludesfactorssuchasprimaryval- vular insufficiency, venous outflow ob- struction (...) than 6 months’ duration. The classic and almost pathognomonic presentation includes varying degrees of positional pelvic and lower back pain exacerbated by prolonged stand- ingandstrenuousactivity. The pain is often described as heaviness and full- ness in the lower pelvis, vulvar region, andthighs.Thepainistypicallyexacer- bated with menses and may be associ- ated with dyspareunia and prolonged postcoital discomfort. Symptoms are typically most severe at the end of the day. Patients frequently

2010 Society of Interventional Radiology

87. Postcoital Testing Study of the SILCS Diaphragm Used With 3% N-9 Gel, ContraGel, or No Gel

Protected from pregnancy by female tubal sterilization Vaginal and cervical anatomy that, in the opinion of the investigator, lends itself to easy genital tract sample collection Willing to give voluntary consent, sign an informed consent form and comply with study procedures as required by the protocol Exclusion Criteria: History of hysterectomy Vasectomy in male partner Sterility or known history of sperm dysfunction in male partner Currently pregnant or within two calendar months from the last (...) for eligibility Positive test for Trichomonas vaginalis, Neisseria gonorrhea or Chlamydia trachomatis Deep epithelial genital findings such as abrasions, ulcerations, and lacerations, or vesicles suspicious for a sexually transmitted infection Positive test for HIV Chronic or acute vulvar or vaginal symptoms (pain, irritation, spotting, etc.) Known current drug or alcohol abuse which could impact study compliance Participation in any other investigational trial within the last 30 days or planned participation

2014 Clinical Trials

88. Phase I One-month Safety, PK, PD, and Acceptability Study of IVR Releasing TFV and LNG or TFV Alone

the sixth day after the last study visit. Willing to abstain from any other vaginal activity and the use of vaginal product other than the study product including tampons, spermicides, lubricants, and douches starting 48 hours before Visit 3 until the sixth day after the last study visit Vaginal and cervical anatomy that, in the opinion of the investigator, lends itself to easy colposcopy and genital tract sample collection Negative urine pregnancy test P4 ≥3 ng/ml Willing to give voluntary consent (...) : Women with a history of genital herpes or condylomata who have been asymptomatic for at least six months may be considered for eligibility. Nugent score greater than or equal to 7 or symptomatic bacterial vaginosis (BV) as defined by Amsel's criteria Positive test for Trichomonas vaginalis, Neisseria gonorrhea (GC), Chlamydia trachomatis (CT), HIV, or Hepatitis B surface antigen (HBsAg) Known bleeding disorder that could lead to prolonged or continuous bleeding with biopsy Chronic or acute vulvar

2014 Clinical Trials

89. A Volume, Motion, and Anatomically Adaptive Approach to Photon and Proton Beam Radiotherapy

: Abramson Cancer Center of the University of Pennsylvania Information provided by (Responsible Party): Abramson Cancer Center of the University of Pennsylvania Study Details Study Description Go to Brief Summary: This pilot study will determine changes over time in tumor volume/motion & patient anatomy, as well as dose distributions to normal organs. The study will inform medical decision-making about need for (and timing of) re-calibration of radiation dosimetry plans. Weekly CT and/or serial MR scans (...) research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Aged 18 and above. Biopsy proven diagnosis of non-small cell lung cancer, small cell lung cancer, head and neck, esophageal, gastric, pancreatic, anal, hepatic, biliary, colorectal, cervical, endometrial, vaginal, vulvar, ovarian cancer

2014 Clinical Trials

90. LUXSOL(TM) Topical Cream for the Treatment of Symptomatic Bacterial Vaginosis; A Proof of Concept Study

cause of vulvovaginitis Subject has another vaginal or vulvar condition that would confound the determination of study endpoints. Subject has received antifungal or antimicrobial therapy (systemic or intravaginal) within the last 14 days prior to enrollment. Subject is under treatment for cervical intra-epithelial neoplasia or cervical carcinoma Subject is known to be HIV positive Subject has a positive pregnancy test Subject has any abnormal anatomy or pathology of the vagina Subject has untreated

2014 Clinical Trials

91. Chronic pelvic floor dysfunction. (Abstract)

muscular, visceral, bony, and fascial dysfunctions. It appears that normalizing all of those disorders plays a pivotal role in reducing complaints of chronic vulvar pain and sexual dysfunction. Though the studies have yet to prove a specific protocol, physical therapists trained in pelvic dysfunction are reporting success with restoring tissue normalcy and reducing vulvar and sexual pain. A review of pelvic anatomy and common findings are presented along with suggested physical therapy management (...) Chronic pelvic floor dysfunction. The successful treatment of women with vestibulodynia and its associated chronic pelvic floor dysfunctions requires interventions that address a broad field of possible pain contributors. Pelvic floor muscle hypertonicity was implicated in the mid-1990s as a trigger of major chronic vulvar pain. Painful bladder syndrome, irritable bowel syndrome, fibromyalgia, and temporomandibular jaw disorder are known common comorbidities that can cause a host of associated

2014 Best practice & research. Clinical obstetrics & gynaecology

92. Vulvovaginitis (Follow-up)

Vulvovaginitis (Follow-up) Vulvovaginitis: Practice Essentials, Background, Anatomy Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjE4ODkzMS1vdmVydmlldw== processing > Vulvovaginitis Updated: Jan 19, 2018 Author (...) : Jill M Krapf, MD, FACOG; Chief Editor: Christine Isaacs, MD Share Email Print Feedback Close Sections Sections Vulvovaginitis Overview Practice Essentials Vulvovaginitis is a general term referring to many types of vaginal infection, although this article focuses on the following disorders, which affect the vulvar region: Vulvovaginal candidiasis Atrophic vaginitis Vulvar vestibulitis Contact dermatitis Signs and symptoms Acute vulvovaginal candidiasis Vulvar pruritus and burning - Primary symptoms

2014 eMedicine.com

93. The Role of Sentinel Node Biopsy in Skin Cancer (Diagnosis)

, vulvar carcinoma, penile cancer, pediatric soft tissue sarcoma, and clear cell sarcoma (melanoma of the soft parts). Previous Next: Relevant Anatomy The concept of sentinel lymph node biopsy is that a primary or sentinel lymph node (or nodes) exists through which tumor cells from a primary tumor in a particular location first must travel, via afferent lymphatics, to spread to a particular regional lymph node basin. The technique is well suited for application to cutaneous malignancies because (...) . Diagnosis and treatment of interval sentinel lymph nodes in patients with cutaneous melanoma. Plast Reconstr Surg . 2007 Mar. 119(3):907-13. . Thompson JF, Uren RF, Shaw HM, et al. Location of sentinel lymph nodes in patients with cutaneous melanoma: new insights into lymphatic anatomy. J Am Coll Surg . 1999 Aug. 189(2):195-204. . Scarsbrook AF, Ganeshan A, Bradley KM. Pearls and pitfalls of radionuclide imaging of the lymphatic system. Part 1: sentinel node lymphoscintigraphy in malignant melanoma. Br

2014 eMedicine.com

94. Benign Cervical Lesions (Follow-up)

Benign Cervical Lesions (Follow-up) Benign Cervical Lesions: Embryology, Anatomy, Physiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjY0OTY2LW92ZXJ2aWV3 processing > Benign Cervical Lesions Updated: Oct 08 (...) , sinovaginal bulb). Through a process of squamous metaplasia, the vagina and a variable portion of the ectocervix become covered with squamous epithelium. This process is complete by the fifth month of pregnancy. Next: Anatomy The cervix (Latin for neck) is the inferior part of the uterus protruding into the vagina. Gross anatomy The cervix measures 2.5-3 cm in diameter and 3-5 cm in length. The normal anatomic position of the cervix is angulated slightly downward and backward. Inferiorly, the cervix

2014 eMedicine.com

95. Uterine Prolapse (Diagnosis)

are available. When planning the appropriate approach, the surgeon must consider operative risk, coital activity, and vaginal canal anatomy. The following list illustrates variables that must be considered. Important considerations for nonsurgical or surgical decision making See the list below: Medical condition and age Severity of symptoms Patient's choice (ie, surgery or no surgery) Patient's suitability for surgery Presence of other pelvic conditions requiring simultaneous treatment, including urinary (...) or fecal incontinence Presence or absence of urethral hypermobility Presence or absence of pelvic floor neuropathy History of previous pelvic surgery Previous Next: Relevant Anatomy Knowledge of the anatomy of the pelvis is essential to understanding prolapse. Teleologic reasoning aids in the understanding of POP. The pelvic floor evolved in primates, particularly humans, who as bipeds, spend most of their waking hours in the upright position. As the name suggests, the floor of the pelvis is the lowest

2014 eMedicine.com

96. Nephrolithiasis: Acute Renal Colic (Diagnosis)

Nephrolithiasis: Acute Renal Colic (Diagnosis) Nephrolithiasis: Practice Essentials, Background, Anatomy Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNDM3MDk2LW92ZXJ2aWV3 processing > Nephrolithiasis Updated (...) and characteristics of pain in nephrolithiasis include the following: Stones obstructing ureteropelvic junction: Mild to severe deep flank pain without radiation to the groin; irritative voiding symptoms (eg, frequency, dysuria); suprapubic pain, urinary frequency/urgency, dysuria, stranguria, bowel symptoms Stones within ureter: Abrupt, severe, colicky pain in the flank and ipsilateral lower abdomen; radiation to testicles or vulvar area; intense nausea with or without vomiting Upper ureteral stones: Radiate

2014 eMedicine.com

97. Nephrolithiasis (Diagnosis)

Nephrolithiasis (Diagnosis) Nephrolithiasis: Practice Essentials, Background, Anatomy Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNDM3MDk2LW92ZXJ2aWV3 processing > Nephrolithiasis Updated: Jun 21, 2018 Author (...) in nephrolithiasis include the following: Stones obstructing ureteropelvic junction: Mild to severe deep flank pain without radiation to the groin; irritative voiding symptoms (eg, frequency, dysuria); suprapubic pain, urinary frequency/urgency, dysuria, stranguria, bowel symptoms Stones within ureter: Abrupt, severe, colicky pain in the flank and ipsilateral lower abdomen; radiation to testicles or vulvar area; intense nausea with or without vomiting Upper ureteral stones: Radiate to flank or lumbar areas

2014 eMedicine.com

98. Nonneoplastic Epithelial Disorders of the Vulva (Diagnosis)

Nonneoplastic Epithelial Disorders of the Vulva (Diagnosis) Benign Vulvar Lesions: Overview, Etiology and Pathophysiology, Clinical History and Physical Findings Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjY0NjQ4LW92ZXJ2aWV3 processing > Benign Vulvar Lesions Updated: Apr 05, 2019 Author: Robert A Schwartz, MD, MPH; Chief Editor: Michel E Rivlin, MD Share Email Print Feedback Close Sections Sections Benign Vulvar Lesions Overview Overview In the last few years, interest in vulvar disease has greatly increased. However, the relevant material has been scattered throughout the literature of various specialties, including dermatology, genitourinary medicine, gynecology, and pathology. The spectrum of involved

2014 eMedicine.com

99. Normal and Abnormal Puerperium (Diagnosis)

to the nonpregnant state. An overview of the relevant anatomy and physiology in the postpartum period follows. Uterus The pregnant term uterus (not including baby, placenta, fluids, etc) weighs approximately 1000 g. In the 6 weeks following delivery, the uterus recedes to a weight of 50-100 g. Immediately postpartum, the uterine fundus is palpable at or near the level of the maternal umbilicus. Thereafter, most of the reduction in size and weight occurs in the first 2 weeks, at which time the uterus has shrunk (...) sphincter complex as well as the anal epithelium. Any deep perineal laceration noted after a delivery warrants a thorough evaluation including a digital rectal exam to improve the diagnosis of OASIS. Approximately 4% of women have a clinically recognized OASIS immediately after time of vaginal delivery . [ ] Other tears after childbirth include periclitoral, periurethral, and labial lacerations; these should only be repaired to achieve hemostasis or to correct distorted anatomy. Additionally

2014 eMedicine.com

100. Radiation Therapy in Gynecology (Diagnosis)

to the pelvic sidewall and/or causing hydronephrosis or a nonfunctioning kidney Stage IVA - Invasion of the bladder or rectal mucosa Stage IVB - Distant metastasis (the para-aortic lymph nodes are considered a distant metastatic site) Vulvar cancer The current FIGO/AJCC staging guidelines for vulvar cancer are as follows: Stage IA - Tumor confined to the vulva or perineum and 2 cm or smaller with stromal invasion 1 mm or less, negative nodes Stage IB – Tumor confined to the vulva or perineum, larger than 2 (...) have significantly higher rates of regional lymph node metastases, locoregional and distant-site relapse, and poor outcome. Because direct extension of tumor into adjacent structures limits the ability of surgery to gain clear surgical margins, and the presence of the uterus is critical for the anatomy of brachytherapy insertion in this setting, primary chemoradiotherapy is generally indicated for the management of stage IIB-IVA locally advanced cervical cancer. Tumoral resection with anterior

2014 eMedicine.com

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