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Vulvar Anatomy

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61. Optimizing Brachytherapy Application and Delivery With MRI Guidance for Gynecologic Cancer

tumor control and a lower risk of side effects. The investigators will also evaluate new MRI protocols to better define the tumor at the time of brachytherapy. The brachytherapy treatment planning and delivery will follow standard of care. In the past, brachytherapy treatment planning and delivery for gynecologic cancer was based on plain-film X-rays, which did not account for the shape of the tumor, the unique anatomy of an individual patient or the response to pelvic radiation therapy. In the last (...) for brachytherapy treatment planning per standard clinical practice The brachytherapy modality to be used is high-dose-rate brachytherapy using an iridum-192 stepping source Device: MRI Medical imaging technique used in radiology to form pictures of the anatomy and the physiological processes of the body Radiation: Brachytherapy Radiation therapy that is delivered by inserting radioactive sources directly into a tumor Device: MRI Tracker The MR tracking device consists of a series of radiofrequency (RF

2017 Clinical Trials

62. Safety, PK, and PD Study of IVRs Releasing TFV and LNG

, and for 5 days after tissue collection Vaginal and cervical anatomy that, in the opinion of the investigator, lends itself to easy genital tract sample collection Negative urine pregnancy test P4 ≥3 ng/ml Willing to give voluntary consent and sign an informed consent form Willing and able to comply with protocol requirements Exclusion Criteria: BMI ≥ 30 kg/m2 History of hysterectomy Currently pregnant or within two calendar months from the last pregnancy outcome. Note: If recently pregnant, must have (...) trachomatis (CT), HIV-1, or Hepatitis B surface antigen (HBsAg) Known bleeding disorder, including deep vein thrombosis (DVT) and pulmonary embolism (PE), or those that could lead to prolonged or continuous bleeding with biopsy Chronic or acute vulvar or vaginal symptoms (pain, irritation, spotting/bleeding, discharge, etc.) Known current drug or alcohol abuse which could impact study compliance Grade 2 or higher laboratory abnormality, per the 2014 update of the Division of AIDS, National Institute

2017 Clinical Trials

63. Laser Fluorescence in Cancer Surgical Treatment

Saúde Fundação Faculdade de Medicina Information provided by (Responsible Party): Instituto do Cancer do Estado de São Paulo Study Details Study Description Go to Brief Summary: The use of fluorescence for real-time evaluation of organ and tissue vascularization and lymph node anatomy is a recent technology with potential for the surgical treatment of cancer. The real-time analysis of tissue vascularization allows immediate identification to the surgeon of areas with greater or lesser blood (...) , skin cancer, cervical cancer, vulvar cancer, head and neck, lung cancer, penile cancer, cancer Endometrial cancer, gastric cancer and esophageal cancer. These early studies demonstrated the feasibility of this methodology during surgery. Comparison of laser fluorescence images on blue dyes indicate that fluorescence images can replace blue dyes because they exceed them due to increased tissue penetration depth and absence of staining in the patient and cleaning of the operative field. To date

2017 Clinical Trials

64. The EANM clinical and technical guidelines for lymphoscintigraphy and sentinel node localization in gynaecological cancers

in gynaecologicalcancer(i.e.vaginal,vulvar,cervical,endome- trialorovariancancer)includesasequenceofprocedureswith componentsfromdifferentmedicalspecialities(nuclearmed- icine, radiology, surgical oncology and pathology). These guidelines are divided into sectione entitled: Purpose, Back- ground information and definitions, Clinical indications and contraindicationsforSLNdetection,Procedures(inthenucle- armedicinedepartment,inthesurgicalsuite,andforradiation dosimetry), and Issues requiring further clarification (...) with gynaecological cancer. These guidelines describe the proto- cols currently used in clinical routine (vulvar and cervical cancers) and in investigational approaches (vaginal, endome- trial and ovarian cancers), but does not include all existing procedures. It should therefore not be taken as exclusive of other nuclear medicine modalities that can be used to obtain comparable results. It is important to remember that the re- sourcesandfacilitiesavailableforpatientcaremayvaryfrom one country to another and from

2014 European Association of Nuclear Medicine

65. Penile Lichen Sclerosus

Sclerosus Aka: Penile Lichen Sclerosus , Balanitis Xerotica Obliterans From Related Chapters II. Definition Idiopathic (possibly autoimmune), chronic inflammatory condition of peri-mucosal skin Typically vulvar involvement in women is more common III. Epidemiology Average age of onset 42 years : One in 300 males IV. Symptoms Asymptomatic in one third of patients Pruritic foreskin May bleed May be severe enough to interfere with sleep Urinary obstruction (long-standing cases) Painful s Painful (if s (...) present) V. Signs Initial Glans and foreskin is thick and white Contiguous edema may be present Later Foreskin in thin, wrinkled and hypopigmented (like cellophane) may be present Last Foreskin and contiguous anatomy distorted May obscure surrounding antomy may occur in men (may result in obstructive uropathy) VI. Labs: Biopsy Biopsy especially indicated if squamous cell hyperplasia present Risk of developing of the foreskin is 4-6% in Biopsy foreskin lesions that fail to heal with management (see

2018 FP Notebook

66. Lichen Sclerosus

resorbed Later or foreskin in thin, wrinkled and hypopigmented (like celophane) may be present Last or foreskin and contiguous anatomy distorted May obscure surrounding antomy Clitoris and labia minora may appear buried in women may occur in men (may result in obstructive uropathy) V. Labs: Biopsy Biopsy especially indicated if squamous cell hyperplasia present Risk of developing of the vulva or foreskin is 5% in Lichen Sclerosus Also biopsy vulvar or foreskin lesions that fail to heal with management (...) browser window. Related Studies (from Trip Database) Ontology: Lichen Sclerosus et Atrophicus (C0023652) Definition (MSH) A chronic inflammatory mucocutaneous disease usually affecting the female genitalia (VULVAR LICHEN SCLEROSUS) and BALANITIS XEROTICA OBLITERANS in males. It is also called white spot disease and Csillag's disease. Definition (NCI) A chronic inflammatory process affecting the skin. It is characterized by the presence of white, indurated plaques, epidermal atrophy, and fibrosis

2018 FP Notebook

67. Vaginal Cancer Treatment (PDQ®): Health Professional Version

cancer in the United States in 2020:[ ] New cases: 6,230. Deaths: 1,450. Anatomy Normal female reproductive system anatomy. Risk Factors Increasing age is the most important risk factor for most cancers. Other risk factors for vaginal cancer include the following: Human papillomavirus (HPV) infection. SCC of the vagina is associated with a high rate of infection with oncogenic strains of HPV and has many risk factors in common with SCC of the cervix.[ - ] HPV infection has also been described (...) , 2019, pp 1171-1210. Daling JR, Madeleine MM, Schwartz SM, et al.: A population-based study of squamous cell vaginal cancer: HPV and cofactors. Gynecol Oncol 84 (2): 263-70, 2002. [ ] Smith JS, Backes DM, Hoots BE, et al.: Human papillomavirus type-distribution in vulvar and vaginal cancers and their associated precursors. Obstet Gynecol 113 (4): 917-24, 2009. [ ] Wright VC, Chapman W: Intraepithelial neoplasia of the lower female genital tract: etiology, investigation, and management. Semin Surg

2015 PDQ - NCI's Comprehensive Cancer Database

68. Cervical Cancer Treatment (PDQ®): Health Professional Version

.[ ] Most cases of cervical cancer are preventable by routine screening and by treatment of precancerous lesions. As a result, most of the cervical cancer cases are diagnosed in women who live in regions with inadequate screening protocols. Incidence and Mortality Estimated new cases and deaths from cervical (uterine cervix) cancer in the United States in 2020:[ ] New cases: 13,800. Deaths: 4,290. Anatomy The uterine cervix is contiguous with the uterine body, and it acts as the opening to the body

2015 PDQ - NCI's Comprehensive Cancer Database

69. Lymphedema (PDQ®): Health Professional Version

status, decreased range of motion, age, and obesity are taken into account.[ ] This summary will review issues related to anatomy and pathophysiology of lymphedema related to cancer, its clinical manifestations, diagnosis, and treatment. Primary (congenital) lymphedema and non–cancer-related lymphedema (e.g., recurrent cellulitis, connective tissue disease, and infection) will not be reviewed here. In this summary, unless otherwise stated, evidence and practice issues as they relate to adults (...) are discussed. The evidence and application to practice related to children may differ significantly from information related to adults. When specific information about the care of children is available, it is summarized under its own heading. Anatomy and Pathophysiology of the Lymphatic System The human lymphatic system generally includes superficial or primary lymphatic vessels that form a complex dermal network of capillarylike channels that drain into larger, secondary lymphatic vessels located

2015 PDQ - NCI's Comprehensive Cancer Database

70. Anal Cancer Prevention (PDQ®): Patient Version

, is about 1-1½ inches long. Anatomy of the lower digestive system, showing the colon and other organs. The skin around the outside of the anus is called the perianal area. in this area are skin tumors, not . See the following summary for more information about anal cancer: Squamous cell carcinoma is the most common type of anal cancer. In the United States, the most common type of anal cancer is . Studies show that (HPV) is the main cause of this type of anal cancer. Another type of anal cancer, called (...) with weakened immune systems who are infected with HPV have a higher risk of anal cancer. Certain medical conditions History of cervical, vaginal, or vulvar cancer , , and are related to HPV infection. Women who have had cervical, vaginal, or vulvar cancer have a higher risk of anal cancer. HIV infection/AIDS Being infected with (HIV) is a strong risk factor for anal cancer. HIV is the cause of (AIDS). HIV weakens the body's immune system and its ability to fight infection. HPV infection of the anus

2014 PDQ - NCI's Comprehensive Cancer Database

71. Plexiform schwannoma: an unusual clitoral mass. (Abstract)

with a large clitoral schwannoma and subsequent treatment with partial vulvectomy. The workup, including advanced pelvic imaging for diagnosis and surgical planning, as well as removal of the clitoral tumor with preservation of functional tissue and restoration of normal vulvar anatomy despite a large excision, is demonstrated.Copyright © 2016 Elsevier Inc. All rights reserved.

2016 American Journal of Obstetrics and Gynecology

72. The versatility of profunda femoral artery perforator flap for oncological reconstruction after cancer resection-Clinical cases and review of literature. (Abstract)

 min. Minor complications included wound poor healing, flap partial necrosis, and pedicle vessels problems. Sixteen pedicle PAP flaps were transferred in 10 patients for vulvar reconstruction. Minor complications included urinary tract infection, poor wound healing, wound infection, hematoma.The anatomy and number of perforators of PAP flap are reliable with adequate pedicle length. This flap can be an excellent option for reconstruction of most soft tissue defects. J. Surg. Oncol. 2016;114:193-201

2016 Journal of Surgical Oncology

73. Excision of an Epidermal Inclusion Cyst: Correction of a Long-term Complication of Female Genital Circumcision. Full Text available with Trip Pro

describe and video-illustrate the surgical technique of excising the 8-cm epidermal inclusion cyst. Using this technique, the entire cyst was resected intact, excess vulvar skin removed, and defect repaired. Postoperatively, she had minimal pain, no dyspareunia, and good cosmesis. Restoration of anatomy for this late complication of female genital circumcision is achievable with knowledge of anatomy, adherence to basic surgical principles that include tension-free closure, and close postoperative

2016 American Journal of Obstetrics and Gynecology

74. Clinical applications of custom-made vaginal cylinders constructed using three-dimensional printing technology Full Text available with Trip Pro

vaginal canal. Patient 3 underwent interstitial brachytherapy boost for stage IIIA vulvar cancer with vaginal extension. For more secure applicator fit within a wide vaginal canal, we printed a 3.5 cm diameter solid cylinder with one central tandem channel and ten peripheral catheter channels. The applicators were printed in a biocompatible, sterilizable thermoplastic.Patient 1 received 31.5 Gy to the surface in three fractions over two weeks. Patient 2 received 36 Gy to the CTV in six fractions over (...) two implants one week apart, with interstitial hyperthermia once per implant. Patient 3 received 18 Gy in three fractions over one implant after 45 Gy external beam radiotherapy. Brachytherapy was tolerated well with no grade 3 or higher toxicity and no local recurrences.We established a workflow to rapidly manufacture and implement customized vaginal applicators that can be sterilized and are made of biocompatible material, resulting in high-quality brachytherapy for patients whose anatomy

2016 Journal of contemporary brachytherapy

75. Vaginal and Sexual Health Treatment Strategies within a Female Sexual Medicine Program for Cancer Patients and Survivors Full Text available with Trip Pro

with gynecologic exam within 8 months of initial visit, and all consecutive follow-ups <6 months apart. Demographics, medical information, and clinical assessments from 175 evaluable patients with at least one follow-up from 09/12 to 10/14 were analyzed. The majority of patients were being treated for or had a history of breast (n = 90, 53 %), gynecologic (n = 54, 32 %), or colorectal/anal (n = 15, 9 %) cancers. An assessment form included a clinician evaluation, Vaginal Assessment Scale (VAS), Vulvar (...) Assessment Scale (VuAS), and patient-reported outcomes. Compliance with treatment recommendations were summarized, and changes over time were compared for clinical outcomes.Mean number of visits was 3.43. Mean age was 55.4 years; 92 % (n = 155/169) were in menopause. Treatment strategies included rationale and instruction for use of vaginal moisturizers, lubricants, pelvic floor exercises, and dilator therapy, in addition to psychosexual education regarding sexual changes (response, anatomy, and function

2016 Journal of cancer survivorship : research and practice

76. The Effect of New-style Vaginal Repair Mesh in the Treatment of Female Stress Urinary Incontinence

were made by Gynemech TM PS, (Johnson & Johnson Shanghai Medical Equipment Co. SFDA registration No. 3460365, size 10 × 15cm) Outcome Measures Go to Primary Outcome Measures : Anatomy of female perineal bilateral pubic bones [ Time Frame: Two months before treatment ] Anatomy of the main parameters of bilateral gap: female perineum pubis bilateral acupoint location, angle, length and width of the acupuncture points. Anatomy of female perineal bilateral pubic bones [ Time Frame: One month after (...) treatment ] Anatomy of the main parameters of bilateral gap: female perineum pubis bilateral acupoint location, angle, length and width of the acupuncture points. Incontinence questionnaire summary table observation [ Time Frame: Three months before treatment ] Incontinence questionnaire summary observation to evaluate the therapeutic effect of the study on the implantation of mesh in female stress urinary incontinence. If there are complications, including the cough so, sneezing or laughing

2016 Clinical Trials

77. Safety and Pharmacokinetics (PK) of a Polyurethane Tenofovir Disoproxil Fumarate (TDF) Vaginal Ring (TDF IVR-002)

traditional herbs or medicines and is willing to refrain from inserting any non-study vaginal products or objects into the vagina, including but not limited to, spermicides, diaphragms, contraceptive vaginal rings, vaginal medications, vaginal probiotics/pre-biotics, menstrual cups, cervical caps (or any other vaginal barrier method), douches, lubricants, vaginal drying agents and sex toys (vibrators, dildos, etc.). Tampons may be used, but for menses only. Vaginal and cervical anatomy (...) nitrate and Monsel's solution. Active hepatitis B infection. Chronic, recurrent, and/or acute vulvar or vaginal symptoms (pain, irritation, spotting, etc.). Known bleeding disorder that could lead to prolonged or continuous bleeding with biopsy. Intending to become pregnant during the period of study participation. Currently breastfeeding or planning to breastfeed during the course of the study. Menopause. History of unexplained or unresolved intermenstrual bleeding in the 3 months prior to screening

2016 Clinical Trials

78. Exploratory Pharmacodynamic Study of Tenofovir-Based Products

, spermicides, lubricants, and douches) other than study products: 48 hours before Visit 2 until six days after Visit 2 48 hours before Visit 3 until six days after Visit 4 Vaginal and cervical anatomy that, in the opinion of the investigator, lends itself to easy genital tract sample collection Estimated calculated creatinine clearance (eCcr) of at least 60 mL/min History of Pap smears and follow-up consistent with standard clinical practice as outlined in the study manual or willing to undergo a Pap smear (...) for Trichomonas vaginalis, Neisseria gonorrhea, Chlamydia trachomatis, HIV, or Hepatitis B surface antigen (HBsAg) Note: Women with a history of genital herpes who have been asymptomatic for at least three months may be considered for eligibility Chronic or acute vulvar or vaginal symptoms (pain, irritation, spotting/bleeding, discharge, etc.) Known bleeding disorder that could lead to prolonged or continuous bleeding with biopsy Systemic use in the last two weeks or anticipated use during the study of any

2016 Clinical Trials

79. Patient Satisfaction of Surgical Treatment of Clitoral Phimosis and Labial Adhesions Caused by Lichen Sclerosus Full Text available with Trip Pro

with surgical correction of clitoral phimosis and lysis of vulvar adhesions for VGF caused by LS. Patients reported improvement in clitoral sensation and ability to achieve orgasm, as well as decreased dyspareunia. Surgical correction of vulvar scarring is a viable option to restore vulvar anatomy and sexual function in appropriate candidates with anogenital LS. Flynn AN, King M, Rieff M, Krapf J, and Goldstein AT. Patient satisfaction of surgical treatment of clitoral phimosis and labial adhesions caused (...) Patient Satisfaction of Surgical Treatment of Clitoral Phimosis and Labial Adhesions Caused by Lichen Sclerosus Lichen sclerosus (LS) is a chronic inflammatory dermatosis, usually affecting the anogenital skin in women. This chronic inflammation can cause scarring of genitalia including narrowing of the introitus and phimosis of the clitoris. These architectural changes can lead to recurrent tearing during intercourse (vulvar granuloma fissuratum) and decreased clitoral sensation. Surgical

2015 Sexual Medicine

80. A Safety Study Of The Caya® Diaphragm Used With ContraGel®

by female sterilization Vaginal and cervical anatomy that, in the opinion of the investigator, lends itself to easy colposcopy and genital tract sample collection Willing to give voluntary consent, sign an informed consent form and comply with study procedures as required by the protocol Exclusion Criteria: Volunteers must meet none of the following criteria prior to genital sampling at Visit 2. History of hysterectomy Currently pregnant or within two calendar months from the last pregnancy outcome (...) or continuous bleeding with biopsy Chronic or acute vulvar or vaginal symptoms (pain, irritation, spotting/bleeding, discharge, etc.) Known current drug or alcohol abuse which could impact study compliance Participation in any other investigational trial within the last 30 days or planned participation in any other investigational trial during the study History of gynecological procedures (including genital piercing) on the external genitalia, vagina or cervix within the last 14 days Systemic use

2015 Clinical Trials

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