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Vulvar Anatomy

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61. Excision of an Epidermal Inclusion Cyst: Correction of a Long-term Complication of Female Genital Circumcision. (PubMed)

describe and video-illustrate the surgical technique of excising the 8-cm epidermal inclusion cyst. Using this technique, the entire cyst was resected intact, excess vulvar skin removed, and defect repaired. Postoperatively, she had minimal pain, no dyspareunia, and good cosmesis. Restoration of anatomy for this late complication of female genital circumcision is achievable with knowledge of anatomy, adherence to basic surgical principles that include tension-free closure, and close postoperative

2016 American Journal of Obstetrics and Gynecology

62. Penile Lichen Sclerosus

Sclerosus Aka: Penile Lichen Sclerosus , Balanitis Xerotica Obliterans From Related Chapters II. Definition Idiopathic (possibly autoimmune), chronic inflammatory condition of peri-mucosal skin Typically vulvar involvement in women is more common III. Epidemiology Average age of onset 42 years : One in 300 males IV. Symptoms Asymptomatic in one third of patients Pruritic foreskin May bleed May be severe enough to interfere with sleep Urinary obstruction (long-standing cases) Painful s Painful (if s (...) present) V. Signs Initial Glans and foreskin is thick and white Contiguous edema may be present Later Foreskin in thin, wrinkled and hypopigmented (like cellophane) may be present Last Foreskin and contiguous anatomy distorted May obscure surrounding antomy may occur in men (may result in obstructive uropathy) VI. Labs: Biopsy Biopsy especially indicated if squamous cell hyperplasia present Risk of developing of the foreskin is 4-6% in Biopsy foreskin lesions that fail to heal with management (see

2018 FP Notebook

63. Lichen Sclerosus

resorbed Later or foreskin in thin, wrinkled and hypopigmented (like celophane) may be present Last or foreskin and contiguous anatomy distorted May obscure surrounding antomy Clitoris and labia minora may appear buried in women may occur in men (may result in obstructive uropathy) V. Labs: Biopsy Biopsy especially indicated if squamous cell hyperplasia present Risk of developing of the vulva or foreskin is 5% in Lichen Sclerosus Also biopsy vulvar or foreskin lesions that fail to heal with management (...) browser window. Related Studies (from Trip Database) Ontology: Lichen Sclerosus et Atrophicus (C0023652) Definition (MSH) A chronic inflammatory mucocutaneous disease usually affecting the female genitalia (VULVAR LICHEN SCLEROSUS) and BALANITIS XEROTICA OBLITERANS in males. It is also called white spot disease and Csillag's disease. Definition (NCI) A chronic inflammatory process affecting the skin. It is characterized by the presence of white, indurated plaques, epidermal atrophy, and fibrosis

2018 FP Notebook

64. The versatility of profunda femoral artery perforator flap for oncological reconstruction after cancer resection-Clinical cases and review of literature. (PubMed)

 min. Minor complications included wound poor healing, flap partial necrosis, and pedicle vessels problems. Sixteen pedicle PAP flaps were transferred in 10 patients for vulvar reconstruction. Minor complications included urinary tract infection, poor wound healing, wound infection, hematoma.The anatomy and number of perforators of PAP flap are reliable with adequate pedicle length. This flap can be an excellent option for reconstruction of most soft tissue defects. J. Surg. Oncol. 2016;114:193-201

2016 Journal of Surgical Oncology

65. Vaginal and Sexual Health Treatment Strategies within a Female Sexual Medicine Program for Cancer Patients and Survivors (PubMed)

with gynecologic exam within 8 months of initial visit, and all consecutive follow-ups <6 months apart. Demographics, medical information, and clinical assessments from 175 evaluable patients with at least one follow-up from 09/12 to 10/14 were analyzed. The majority of patients were being treated for or had a history of breast (n = 90, 53 %), gynecologic (n = 54, 32 %), or colorectal/anal (n = 15, 9 %) cancers. An assessment form included a clinician evaluation, Vaginal Assessment Scale (VAS), Vulvar (...) Assessment Scale (VuAS), and patient-reported outcomes. Compliance with treatment recommendations were summarized, and changes over time were compared for clinical outcomes.Mean number of visits was 3.43. Mean age was 55.4 years; 92 % (n = 155/169) were in menopause. Treatment strategies included rationale and instruction for use of vaginal moisturizers, lubricants, pelvic floor exercises, and dilator therapy, in addition to psychosexual education regarding sexual changes (response, anatomy, and function

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2016 Journal of cancer survivorship : research and practice

66. Clinical applications of custom-made vaginal cylinders constructed using three-dimensional printing technology (PubMed)

vaginal canal. Patient 3 underwent interstitial brachytherapy boost for stage IIIA vulvar cancer with vaginal extension. For more secure applicator fit within a wide vaginal canal, we printed a 3.5 cm diameter solid cylinder with one central tandem channel and ten peripheral catheter channels. The applicators were printed in a biocompatible, sterilizable thermoplastic.Patient 1 received 31.5 Gy to the surface in three fractions over two weeks. Patient 2 received 36 Gy to the CTV in six fractions over (...) two implants one week apart, with interstitial hyperthermia once per implant. Patient 3 received 18 Gy in three fractions over one implant after 45 Gy external beam radiotherapy. Brachytherapy was tolerated well with no grade 3 or higher toxicity and no local recurrences.We established a workflow to rapidly manufacture and implement customized vaginal applicators that can be sterilized and are made of biocompatible material, resulting in high-quality brachytherapy for patients whose anatomy

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2016 Journal of contemporary brachytherapy

67. Urethral Cancer Treatment (PDQ®): Health Professional Version

information about the treatment of urethral cancer and the outcomes of therapy is derived from retrospective, single-center case series and, therefore, represents a very low level of evidence of . The majority of information comes from cases accumulated over many decades at major academic centers. Anatomy The female urethra is largely contained within the anterior vaginal wall. In adults, it is about 4 cm in length. The male urethra, which averages about 20 cm in length, is divided into distal (...) and proximal portions. The distal urethra, which extends distally to proximally from the tip of the penis to just before the prostate, includes the meatus, the fossa navicularis, the penile or pendulous urethra, and the bulbar urethra. The proximal urethra, which extends from the bulbar urethra to the bladder neck, includes distally to proximally the membranous urethra and the prostatic urethra. Anatomy of the male urinary system (left panel) and female urinary system (right panel) showing the kidneys

2015 PDQ - NCI's Comprehensive Cancer Database

68. Cervical Cancer Treatment (PDQ®): Health Professional Version

.[ ] Most cases of cervical cancer are preventable by routine screening and by treatment of precancerous lesions. As a result, most of the cervical cancer cases are diagnosed in women who live in regions with inadequate screening protocols. Incidence and Mortality Estimated new cases and deaths from cervical (uterine cervix) cancer in the United States in 2019:[ ] New cases: 13,170. Deaths: 4,250. Anatomy The uterine cervix is contiguous with the uterine body, and it acts as the opening to the body

2015 PDQ - NCI's Comprehensive Cancer Database

69. Lymphedema (PDQ®): Health Professional Version

status, decreased range of motion, age, and obesity are taken into account.[ ] This summary will review issues related to anatomy and pathophysiology of lymphedema related to cancer, its clinical manifestations, diagnosis, and treatment. Primary (congenital) lymphedema and non–cancer-related lymphedema (e.g., recurrent cellulitis, connective tissue disease, and infection) will not be reviewed here. In this summary, unless otherwise stated, evidence and practice issues as they relate to adults (...) are discussed. The evidence and application to practice related to children may differ significantly from information related to adults. When specific information about the care of children is available, it is summarized under its own heading. Anatomy and Pathophysiology of the Lymphatic System The human lymphatic system generally includes superficial or primary lymphatic vessels that form a complex dermal network of capillarylike channels that drain into larger, secondary lymphatic vessels located

2015 PDQ - NCI's Comprehensive Cancer Database

70. Anal Cancer Prevention (PDQ®): Patient Version

, is about 1-1½ inches long. Anatomy of the lower digestive system, showing the colon and other organs. The skin around the outside of the anus is called the perianal area. in this area are skin tumors, not . See the following summary for more information about anal cancer: Squamous cell carcinoma is the most common type of anal cancer. In the United States, the most common type of anal cancer is . Studies show that (HPV) is the main cause of this type of anal cancer. Another type of anal cancer, called (...) cases of anal cancer are found in patients with HPV . Patients with healthy are usually able to fight HPV infections. Patients with weakened immune systems who are infected with HPV have a higher risk of anal cancer. Certain medical conditions History of cervical, vaginal, or vulvar cancer , , and are related to HPV infection. Women who have had cervical, vaginal, or vulvar cancer have a higher risk of anal cancer. HIV infection/AIDS Being infected with (HIV) is a strong risk factor for anal cancer

2014 PDQ - NCI's Comprehensive Cancer Database

71. Research Reporting Standards for Endovascular Treatment of Pelvic Venous Insufficiency

in the lower pelvis, vulvar region, and upper thighs. The pain is typicallyexacerbatedwithmensesand may be associated with dyspareunia and prolonged postcoital discomfort. Symptoms are generally most severe at the end of the day and are dimin- ished with supine positioning (24). PVI refers specifically to the patho- physiologyofretrogradeflowthrough incompetentgonadalandpelvicveins. The etiology of PVI is multifactorial, andincludesfactorssuchasprimaryval- vular insufficiency, venous outflow ob- struction (...) than 6 months’ duration. The classic and almost pathognomonic presentation includes varying degrees of positional pelvic and lower back pain exacerbated by prolonged stand- ingandstrenuousactivity. The pain is often described as heaviness and full- ness in the lower pelvis, vulvar region, andthighs.Thepainistypicallyexacer- bated with menses and may be associ- ated with dyspareunia and prolonged postcoital discomfort. Symptoms are typically most severe at the end of the day. Patients frequently

2010 Society of Interventional Radiology

72. Parathyroid Cancer Treatment (PDQ®): Health Professional Version

of affected women to men is 1:1 in contrast to primary HPT in which there is a significant female predominance (ratio of 3–4:1).[ ] Anatomy and Histopathology Operatively, parathyroid cancers may be distinguished from adenomas by their firm, stony-hard consistency and lobulation; adenomas tend to be soft, round, or oval in shape, and of a reddish-brown color.[ ] In most series, the median maximal diameter of parathyroid carcinoma is between 3.0 cm and 3.5 cm compared with approximately 1.5 cm for benign (...) Editorial Board. PDQ Cancer Information Summaries. 2002 [PDQ Cancer Information Summari...] Review Vulvar Cancer Treatment (PDQ®): Health Professional Version PDQ Adult Treatment Editorial Board. PDQ Cancer Information Summaries. 2002 [PDQ Cancer Information Summari...] Review Vaginal Cancer Treatment (PDQ®): Health Professional Version PDQ Adult Treatment Editorial Board. PDQ Cancer Information Summaries. 2002 Recent Activity Parathyroid Cancer Treatment (PDQ®) - PDQ Cancer Information Summaries Your

2013 PDQ - NCI's Comprehensive Cancer Database

73. Sentinel Lymph Node Detection in Endometrial Cancer

patients with nodal metastases, diminish side effects caused by full lymphadenectomy and render some expensive preoperative risk group allocation measures unnecessary. A clinically useful SLN technique requires a high technical success rate, a clear definition of SLN, an algorithm taking into account that metastatic nodes not always accumulate tracer and a reproducible surgical algorithm. A definition of SLN requires knowledge on lymphatic anatomy. Unfortunately all tracers, dyes/radiotracers often (...) is to systematically display the major anatomical pathways with the use of ICG and to evaluate a standardized and reproducible SLN surgical algorithm based on lymphatic anatomy and identification of efferent lymph vessels. Condition or disease Intervention/treatment Phase Endometrial Neoplasms Procedure: Sentinel node procedure Not Applicable Detailed Description: Endometrial cancer is an increasingly common gynecologic malignancy. The cumulative 5-year survival rate for node negative patients is 94%, 75% in those

2015 Clinical Trials

74. Assessing the Disintegration, Safety, and Acceptability of Placebo Vaginal Inserts for the Delivery of Vaginal Products

product use as required in the protocol Vaginal and cervical anatomy that, in the opinion of the investigator, lends itself to easy examination Willing to give voluntary consent, sign an informed consent form and comply with study procedures as required by the protocol Exclusion Criteria: History of hysterectomy Currently pregnant or within two calendar months from the last pregnancy outcome. Note: If recently pregnant must have had at least two spontaneous menses since pregnancy outcome Use of any (...) vulvar or vaginal symptoms (pain, irritation, spotting, etc.) Known current drug or alcohol abuse which could impact study compliance Participation in any other investigational trial (device, drug, or vaginal trial) within the last 30 days or planned participation in any other investigational trial during the study History of gynecological procedures (including genital piercing) on the external genitalia, vagina or cervix within the last 14 days Abnormal finding on physical examination or a social

2015 Clinical Trials

75. A Safety Study Of The Caya® Diaphragm Used With ContraGel®

by female sterilization Vaginal and cervical anatomy that, in the opinion of the investigator, lends itself to easy colposcopy and genital tract sample collection Willing to give voluntary consent, sign an informed consent form and comply with study procedures as required by the protocol Exclusion Criteria: Volunteers must meet none of the following criteria prior to genital sampling at Visit 2. History of hysterectomy Currently pregnant or within two calendar months from the last pregnancy outcome (...) or continuous bleeding with biopsy Chronic or acute vulvar or vaginal symptoms (pain, irritation, spotting/bleeding, discharge, etc.) Known current drug or alcohol abuse which could impact study compliance Participation in any other investigational trial within the last 30 days or planned participation in any other investigational trial during the study History of gynecological procedures (including genital piercing) on the external genitalia, vagina or cervix within the last 14 days Systemic use

2015 Clinical Trials

76. Patient Satisfaction of Surgical Treatment of Clitoral Phimosis and Labial Adhesions Caused by Lichen Sclerosus (PubMed)

with surgical correction of clitoral phimosis and lysis of vulvar adhesions for VGF caused by LS. Patients reported improvement in clitoral sensation and ability to achieve orgasm, as well as decreased dyspareunia. Surgical correction of vulvar scarring is a viable option to restore vulvar anatomy and sexual function in appropriate candidates with anogenital LS. Flynn AN, King M, Rieff M, Krapf J, and Goldstein AT. Patient satisfaction of surgical treatment of clitoral phimosis and labial adhesions caused (...) Patient Satisfaction of Surgical Treatment of Clitoral Phimosis and Labial Adhesions Caused by Lichen Sclerosus Lichen sclerosus (LS) is a chronic inflammatory dermatosis, usually affecting the anogenital skin in women. This chronic inflammation can cause scarring of genitalia including narrowing of the introitus and phimosis of the clitoris. These architectural changes can lead to recurrent tearing during intercourse (vulvar granuloma fissuratum) and decreased clitoral sensation. Surgical

Full Text available with Trip Pro

2015 Sexual Medicine

77. Survey of male perceptions regarding the vulva. (PubMed)

Survey of male perceptions regarding the vulva. The purpose of this study was to characterize male preferences of vulvar appearance, their awareness of labiaplasty, and their knowledge of genital anatomy.Men 18-80 years old were recruited via emails sent by an Internet provider to participate in a 27-question web-based survey. The questionnaire included images and queried demographics, men's familiarity with vulvar anatomy, preferences regarding labial appearance, and awareness of labiaplasty (...) %), married (68%), employed (69%), and had completed high school or beyond (97%). One-third of the respondents lived in the South, with the other regions nearly equally represented. A significant majority, 95%, reported having been sexually active with women, and 86% felt comfortable labeling the vulvar anatomy. With regard to preferences, more respondents considered smaller labia attractive compared to large labia; yet 36% of the men remained neutral. Men also showed a preference for partially

2015 American Journal of Obstetrics and Gynecology

78. Postcoital Testing Study of the SILCS Diaphragm Used With 3% N-9 Gel, ContraGel, or No Gel

Protected from pregnancy by female tubal sterilization Vaginal and cervical anatomy that, in the opinion of the investigator, lends itself to easy genital tract sample collection Willing to give voluntary consent, sign an informed consent form and comply with study procedures as required by the protocol Exclusion Criteria: History of hysterectomy Vasectomy in male partner Sterility or known history of sperm dysfunction in male partner Currently pregnant or within two calendar months from the last (...) for eligibility Positive test for Trichomonas vaginalis, Neisseria gonorrhea or Chlamydia trachomatis Deep epithelial genital findings such as abrasions, ulcerations, and lacerations, or vesicles suspicious for a sexually transmitted infection Positive test for HIV Chronic or acute vulvar or vaginal symptoms (pain, irritation, spotting, etc.) Known current drug or alcohol abuse which could impact study compliance Participation in any other investigational trial within the last 30 days or planned participation

2014 Clinical Trials

79. Phase I One-month Safety, PK, PD, and Acceptability Study of IVR Releasing TFV and LNG or TFV Alone

the sixth day after the last study visit. Willing to abstain from any other vaginal activity and the use of vaginal product other than the study product including tampons, spermicides, lubricants, and douches starting 48 hours before Visit 3 until the sixth day after the last study visit Vaginal and cervical anatomy that, in the opinion of the investigator, lends itself to easy colposcopy and genital tract sample collection Negative urine pregnancy test P4 ≥3 ng/ml Willing to give voluntary consent (...) : Women with a history of genital herpes or condylomata who have been asymptomatic for at least six months may be considered for eligibility. Nugent score greater than or equal to 7 or symptomatic bacterial vaginosis (BV) as defined by Amsel's criteria Positive test for Trichomonas vaginalis, Neisseria gonorrhea (GC), Chlamydia trachomatis (CT), HIV, or Hepatitis B surface antigen (HBsAg) Known bleeding disorder that could lead to prolonged or continuous bleeding with biopsy Chronic or acute vulvar

2014 Clinical Trials

80. LUXSOL(TM) Topical Cream for the Treatment of Symptomatic Bacterial Vaginosis; A Proof of Concept Study

cause of vulvovaginitis Subject has another vaginal or vulvar condition that would confound the determination of study endpoints. Subject has received antifungal or antimicrobial therapy (systemic or intravaginal) within the last 14 days prior to enrollment. Subject is under treatment for cervical intra-epithelial neoplasia or cervical carcinoma Subject is known to be HIV positive Subject has a positive pregnancy test Subject has any abnormal anatomy or pathology of the vagina Subject has untreated

2014 Clinical Trials

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