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Vulvar Anatomy

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41. Tropical Travel Trouble 005 RUQ Pain and Jaundice

fistulas, rectovaginal fistulas, and vulvar and penile skin ulcerations can occur as a result of intestinal disease or secondary to sexual transmission. Surgical wounds can become infected if invaded by a nearby or internal amoebic lesion. Trophozoites can be seen under microscopy in fresh ulcer discharge or scrapings of the ulcer edge. Q5. What is the differential diagnosis for Amoebic liver abscess? Answer and interpretation Pyogenic abscess. Primary hepatocellular carcinoma or metastasis to liver (...) abscess (especially if multiple lesions), as adjunct to medical therapy (no response in 72 hours). If rupture is imminent. If the abscess is >/= 10cm, or if the abscess is in left lobe (increased potential to rupture with critical complications). Surgery should be performed for abscess rupture, bacterial superinfection, or if abscess needs aspiration but percutaneous access limited by anatomy. Perforation, toxic megacolon or abscesses that fail medical treatment, all need surgical intervention

2018 Life in the Fast Lane Blog

42. Parathyroid Cancer Treatment (PDQ®): Health Professional Version

of affected women to men is 1:1 in contrast to primary HPT in which there is a significant female predominance (ratio of 3–4:1).[ ] Anatomy and Histopathology Operatively, parathyroid cancers may be distinguished from adenomas by their firm, stony-hard consistency and lobulation; adenomas tend to be soft, round, or oval in shape, and of a reddish-brown color.[ ] In most series, the median maximal diameter of parathyroid carcinoma is between 3.0 cm and 3.5 cm compared with approximately 1.5 cm for benign (...) Treatment Editorial Board. PDQ Cancer Information Summaries. 2002 [PDQ Cancer Information Summari...] Review Anal Cancer Treatment (PDQ®): Health Professional Version PDQ Adult Treatment Editorial Board. PDQ Cancer Information Summaries. 2002 [PDQ Cancer Information Summari...] Review Vulvar Cancer Treatment (PDQ®): Health Professional Version PDQ Adult Treatment Editorial Board. PDQ Cancer Information Summaries. 2002 Recent Activity Parathyroid Cancer Treatment (PDQ®) - PDQ Cancer Information Summaries

2017 PDQ - NCI's Comprehensive Cancer Database

43. EANM practice guidelines for lymphoscintigraphy and sentinel lymph node biopsy in melanoma ? SNMMI Endorsement

],andinadditionthereisasignificantcostreduc- tion [88]. SPECT/CTshould be performed in head and neck melanoma owing to the complex anatomy [83]. Moreover, SPECT/CT is highly recommended for the groin area and recommended for the axillary area because it facilitates the detection of in-transit nodes and aberrant lymphatic drainage stasisinlymph vesselsandconsequentlyfacilitatesthesurgi- cal procedure [2]. In pregnant patients, SPECTwithout a CT scanshouldbeperformedifaninguinaloraxillarynodalbase is to be imaged. However, for the head

2015 Society of Nuclear Medicine and Molecular Imaging

44. Lymphoscintigraphy and Sentinel Node Localization in Gynecological Cancers ? SNMMI Endorsement

Lymphoscintigraphy and Sentinel Node Localization in Gynecological Cancers ? SNMMI Endorsement GUIDELINES TheEANMclinicalandtechnicalguidelines forlymphoscintigraphyandsentinelnodelocalization ingynaecologicalcancers FrancescoGiammarile &M.FaniBozkurt & DavidCibula &JaumePahisa & WimJ.Oyen & PilarParedes &RenatoValdesOlmos &SergiVidalSicart # Springer-VerlagBerlin Heidelberg 2014 Abstract The accurate harvesting of a sentinel node in gynaecologicalcancer(i.e.vaginal,vulvar,cervical,endome (...) of action based on current knowledge, available re- sources, and the needs of the patient to deliver effective and safe medical care. The sole purpose of these guidelines is to assist practitioners in achieving this objective. Purpose The aim of this document is to provide general information about sentinel lymph node (SLN) detection in patients with gynaecological cancer. These guidelines describe the proto- cols currently used in clinical routine (vulvar and cervical cancers) and in investigational

2014 Society of Nuclear Medicine and Molecular Imaging

45. Genitourinary syndrome of menopause: new terminology for vulvovaginal atrophy from the International Society for the Study of Women's Sexual Health and The North American Menopause Society

be associated with VVA. 12,13,17,29,30 Lower urinary tract symptoms and urinary incontinence have beenassociatedwithbothsystemicagingandmenopause. 30,31 The urethra and the bladder trigone are derived embryolo- gically from the same estrogen receptorYdense primitive Menopause, Vol. 21, No. 10, 2014 1065 GENITOURINARY SYNDROME OF MENOPAUSE Copyright © 2014 The North American Menopause Society. Unauthorized reproduction of this article is prohibited. urogenital sinus tissue, as are the vulvar vestibule (...) . 41,42 In the Clarifying Vaginal Atrophy_s Impact on Sex and Relation- ships(CLOSER)onlinesurvey,lessthanhalfofUSrespondents wereawareofavailabletreatments(nonhormonalorhormonal) to improve vaginal discomfort. 28 Collectively, these findings serve to highlight the lack of discussion, the underdiagnosis, and the undertreatment of vulvar, vaginal, sexual, and urinary symptoms associated with menopause. New Terminology After reviewing the clinical and basic science, diagnosis and therapy options

2014 The North American Menopause Society

46. Safety and Acceptability Study of a Non-Hormonal Ring

requirements including sexual activity/ abstinence and condom use requirements; and Can engage in vaginal intercourse with the participant, with and without condoms, as specified in protocol Vaginal and cervical anatomy that, in the opinion of the investigator, lends itself to easy colposcopy and genital tract sample collection Willing to give voluntary consent, sign an informed consent form and comply with study procedures as required by the protocol Exclusion Criteria: History of hysterectomy Vasectomy (...) STI or pelvic inflammatory disease. Note: Women or male partners with a history of genital herpes or condylomata who have been asymptomatic for at least six months may be considered for eligibility Positive test for Trichomonas vaginalis, Neisseria gonorrhea, Chlamydia trachomatis, or HIV Deep epithelial genital findings such as abrasions, ulcerations, and lacerations, or vesicles suspicious for a sexually transmitted infection Chronic or acute vulvar or vaginal symptoms (pain, irritation

2018 Clinical Trials

47. Intratreatment FDG-PET During Radiation Therapy for Gynecologic and Gastrointestinal Cancers

imaging in multiple types of cancers. The current focus will be more specific to certain types of gastrointestinal and gynecologic cancers treated with RT, identified from the prior study to warrant further research. Condition or disease Intervention/treatment Phase Cancer of the Cervix Vulvar Cancer Esophageal Cancer Anal Canal Cancer Other: FDG PET scan Phase 2 Detailed Description: Intra-treatment PETs have only recently been studied in small pilot series. In rectal cancer, a prospective trial from (...) procedures. Unlike CT or MRI (magnetic resonance imaging), techniques that look at anatomy or body form, PET studies metabolic activity or body function. Other Name: PET scan Outcome Measures Go to Primary Outcome Measures : The number of subjects with benefit from an intra-treatment PET-CT [ Time Frame: 4 years ] This benefit lies in the potential to adapt the treatment plan based on an intratreatment PET-CT. This may also be of significant prognostic utility, at an early enough time point

2018 Clinical Trials

48. Node count and groin recurrence in early vulvar cancer: A Gynecologic Oncology Group study. (PubMed)

Node count and groin recurrence in early vulvar cancer: A Gynecologic Oncology Group study. To determine if low node count from superficial groin dissection correlated with first recurrence in the groin for patients with early vulvar cancer.The Gynecologic Oncology Group (GOG) conducted a trial for patients with early stage squamous vulvar cancer, lesions <2 cm in size and <5 mm in depth. All fatty tissue below the inguinal ligament, medial to the sartorious and lateral to the adductor longus (...) was 7 (range: 4-22). There were no significant differences between patients with first recurrence in the groin and those without (p value=0.7475). There was a broad overlap of the confidence intervals.We were unable to show that groin failure after superficial lymphadenectomy was a result of low lymph node count. The small number of recurrences made firm conclusions impossible. Variations in anatomy and other factors may make node counting an unreliable measure of surgical quality.

2009 Gynecologic Oncology

49. Laser Fluorescence in Cancer Surgical Treatment

Saúde Fundação Faculdade de Medicina Information provided by (Responsible Party): Instituto do Cancer do Estado de São Paulo Study Details Study Description Go to Brief Summary: The use of fluorescence for real-time evaluation of organ and tissue vascularization and lymph node anatomy is a recent technology with potential for the surgical treatment of cancer. The real-time analysis of tissue vascularization allows immediate identification to the surgeon of areas with greater or lesser blood (...) , skin cancer, cervical cancer, vulvar cancer, head and neck, lung cancer, penile cancer, cancer Endometrial cancer, gastric cancer and esophageal cancer. These early studies demonstrated the feasibility of this methodology during surgery. Comparison of laser fluorescence images on blue dyes indicate that fluorescence images can replace blue dyes because they exceed them due to increased tissue penetration depth and absence of staining in the patient and cleaning of the operative field. To date

2017 Clinical Trials

50. Optimizing Brachytherapy Application and Delivery With MRI Guidance for Gynecologic Cancer

tumor control and a lower risk of side effects. The investigators will also evaluate new MRI protocols to better define the tumor at the time of brachytherapy. The brachytherapy treatment planning and delivery will follow standard of care. In the past, brachytherapy treatment planning and delivery for gynecologic cancer was based on plain-film X-rays, which did not account for the shape of the tumor, the unique anatomy of an individual patient or the response to pelvic radiation therapy. In the last (...) for brachytherapy treatment planning per standard clinical practice The brachytherapy modality to be used is high-dose-rate brachytherapy using an iridum-192 stepping source Device: MRI Medical imaging technique used in radiology to form pictures of the anatomy and the physiological processes of the body Radiation: Brachytherapy Radiation therapy that is delivered by inserting radioactive sources directly into a tumor Device: MRI Tracker The MR tracking device consists of a series of radiofrequency (RF

2017 Clinical Trials

51. Safety, PK, and PD Study of IVRs Releasing TFV and LNG

, and for 5 days after tissue collection Vaginal and cervical anatomy that, in the opinion of the investigator, lends itself to easy genital tract sample collection Negative urine pregnancy test P4 ≥3 ng/ml Willing to give voluntary consent and sign an informed consent form Willing and able to comply with protocol requirements Exclusion Criteria: BMI ≥ 30 kg/m2 History of hysterectomy Currently pregnant or within two calendar months from the last pregnancy outcome. Note: If recently pregnant, must have (...) trachomatis (CT), HIV-1, or Hepatitis B surface antigen (HBsAg) Known bleeding disorder, including deep vein thrombosis (DVT) and pulmonary embolism (PE), or those that could lead to prolonged or continuous bleeding with biopsy Chronic or acute vulvar or vaginal symptoms (pain, irritation, spotting/bleeding, discharge, etc.) Known current drug or alcohol abuse which could impact study compliance Grade 2 or higher laboratory abnormality, per the 2014 update of the Division of AIDS, National Institute

2017 Clinical Trials

52. Tridimensional Pelvic Floor Ultrasound and Quality of Life Scores Questionnaires in Nulliparous or Parous Women

. The 3D ultrasound (3D UD) is a non-invasive method, reproductible, and technically easy of evaluate the pelvic floor. Different routes may be used, but the transperineal is the most common. By this route is possible to evaluate the pelvic floor anatomy, as well as its disfunction into deep planes, what we can not afford only with the physical exam. The objective was to evaluate the impact of the delivery on the pelvic floor, by the 3D ultrasound evaluation and to correlate it with the scores (...) (Adult) Sexes Eligible for Study: Female Accepts Healthy Volunteers: Yes Sampling Method: Non-Probability Sample Study Population Reproductive age women, followed in Family Planning Service and Urogynecology Service of Federal of São Paulo University recruited from May 2016 to June 2018. Criteria Inclusion Criteria: age between 18 and 50 reproductive age Exclusion Criteria: bad quality of 3D US images post- menopause vulvovaginitis urinary incontinence Human papillomavirus vulvar disease (condyloma

2017 Clinical Trials

53. MonaLisa Touch Study

is the ability to demonstrate causality. Background: Genitourinary syndrome of Menopause is a condition of postmenopausal women due to estrogen deprivation which results in progressive worsening of the vaginal and vulvar anatomy with symptoms of vulvar itching or pain during intercourse, vaginal dryness, urinary urgency and frequency and frequent bladder infections. It could ultimately lead to vaginal bleeding, petechial hemorrhages, vaginal narrowing or stenosis and hypertonicity of the pelvic muscles due

2017 Clinical Trials

54. Management of symptomatic vulvovaginal atrophy: 2013 position statement of The North American Menopause Society

on localestrogenaswellasonothermanagementoptionsavailable or in development for symptomatic VVA. If the evidence was contradictory or inadequateto form a conclusion, a consensus- based opinion wasestablished. Once the Panel completed its draft, the Position State- ment was submitted to the NAMS Board of Trustees for additional review, comments, and edits. The Board is com- posed of both clinicians and researchers from multiple spe- cialties and disciplines. The Board approved the Position Statementwithedits,andthePanelrevieweditonefinaltime. ANATOMY (...) neuronsinthevagina.Thisfunctionmayservetodecreasethe discomfort associated with VVA. 11 The term vulvovaginal atrophy refers specifically to the changes in the vaginal and vulvar surfaces that on examina- tion arethin,pale,anddry.Thevaginacannarrowandshorten, and the introitus may constrict, especially in the absence of penetrative sexual activity. The vaginal lining may exhibit petechiae and become thinner (often only a few cell layers thick),lesselastic,andprogressivelysmootherasrugalfolds decrease. Vaginal blood flow diminishes. Although

2013 The North American Menopause Society

55. Anal Cancer

types 16 and 18. The quadrivalent HPV vaccine, when given prior to HPV exposure, has been shown to reduce the rates of AIN and should be considered in populations at high risk for anal cancer, which includes men who have sex with men, women with cervical or vulvar cancer, or individuals who are immunosuppressed [22]. Prognostic Factors The size of the primary tumor and the presence of nodal or distant metastases are determinates of outcome. Patients with de novo tumors >5 cm are at significantly (...) . Uncommon anal neoplasms. Surg Oncol Clin N Am. 2004;13(2):375-388. 11. Dujovny N, Quiros RM, Saclarides TJ. Anorectal anatomy and embryology. Surg Oncol Clin N Am. 2004;13(2):277-293. 12. Pineda CE, Welton ML. Management of anal dysplasia. In: Ben-Josef E, Koong A, ed. Radiation Medical Rounds: Lower Gastrointestinal Malignancies. Vol 1, Issue 2. New York, NY: Demos Medical Publishing; 2010:399-408. 13. Kuehn PG, Beckett R, Eisenberg H, Reed JF. Hematogenous Metastases from Epidermoid Carcinoma

2013 American College of Radiology

56. The EANM clinical and technical guidelines for lymphoscintigraphy and sentinel node localization in gynaecological cancers

in gynaecologicalcancer(i.e.vaginal,vulvar,cervical,endome- trialorovariancancer)includesasequenceofprocedureswith componentsfromdifferentmedicalspecialities(nuclearmed- icine, radiology, surgical oncology and pathology). These guidelines are divided into sectione entitled: Purpose, Back- ground information and definitions, Clinical indications and contraindicationsforSLNdetection,Procedures(inthenucle- armedicinedepartment,inthesurgicalsuite,andforradiation dosimetry), and Issues requiring further clarification (...) with gynaecological cancer. These guidelines describe the proto- cols currently used in clinical routine (vulvar and cervical cancers) and in investigational approaches (vaginal, endome- trial and ovarian cancers), but does not include all existing procedures. It should therefore not be taken as exclusive of other nuclear medicine modalities that can be used to obtain comparable results. It is important to remember that the re- sourcesandfacilitiesavailableforpatientcaremayvaryfrom one country to another and from

2014 European Association of Nuclear Medicine

57. The care of patients with varicose veins and associated chronic venous diseases: Clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum (Full text)

, the updated terminology for superficial, perforating, and deep veins of the leg and pelvis are used. x 49 Caggiati, A., Bergan, J.J., Gloviczki, P., Eklof, B., Allegra, C., Partsch, H. et al. Nomenclature of the veins of the lower limb: extensions, refinements, and clinical application. J Vasc Surg . 2005 ; 41 : 719–724 | | | | | , x 50 Mozes, G. and Gloviczki, P. New discoveries in anatomy and new terminology of leg veins: clinical implications. Vasc Endovasc Surg . 2004 ; 38 : 367–374 | | | Definitions (...) . The Pacific Vascular Symposium 6: the Venous Ulcer Summit in perspective. J Vasc Surg . 2010 ; 52 : 1S–2S | | | | | Anatomy During the past decade, new venous terminology has been developed and adopted by vascular societies around the world. x 47 in: P. Gloviczki (Ed.) Handbook of venous disorders: guidelines of the American Venous Forum . 3rd ed. Hodder Arnold , London ; 2009 , x 49 Caggiati, A., Bergan, J.J., Gloviczki, P., Eklof, B., Allegra, C., Partsch, H. et al. Nomenclature of the veins

2011 Society for Vascular Surgery PubMed

58. Safety and Pharmacokinetics (PK) of a Polyurethane Tenofovir Disoproxil Fumarate (TDF) Vaginal Ring (TDF IVR-002)

traditional herbs or medicines and is willing to refrain from inserting any non-study vaginal products or objects into the vagina, including but not limited to, spermicides, diaphragms, contraceptive vaginal rings, vaginal medications, vaginal probiotics/pre-biotics, menstrual cups, cervical caps (or any other vaginal barrier method), douches, lubricants, vaginal drying agents and sex toys (vibrators, dildos, etc.). Tampons may be used, but for menses only. Vaginal and cervical anatomy (...) nitrate and Monsel's solution. Active hepatitis B infection. Chronic, recurrent, and/or acute vulvar or vaginal symptoms (pain, irritation, spotting, etc.). Known bleeding disorder that could lead to prolonged or continuous bleeding with biopsy. Intending to become pregnant during the period of study participation. Currently breastfeeding or planning to breastfeed during the course of the study. Menopause. History of unexplained or unresolved intermenstrual bleeding in the 3 months prior to screening

2016 Clinical Trials

59. Exploratory Pharmacodynamic Study of Tenofovir-Based Products

, spermicides, lubricants, and douches) other than study products: 48 hours before Visit 2 until six days after Visit 2 48 hours before Visit 3 until six days after Visit 4 Vaginal and cervical anatomy that, in the opinion of the investigator, lends itself to easy genital tract sample collection Estimated calculated creatinine clearance (eCcr) of at least 60 mL/min History of Pap smears and follow-up consistent with standard clinical practice as outlined in the study manual or willing to undergo a Pap smear (...) for Trichomonas vaginalis, Neisseria gonorrhea, Chlamydia trachomatis, HIV, or Hepatitis B surface antigen (HBsAg) Note: Women with a history of genital herpes who have been asymptomatic for at least three months may be considered for eligibility Chronic or acute vulvar or vaginal symptoms (pain, irritation, spotting/bleeding, discharge, etc.) Known bleeding disorder that could lead to prolonged or continuous bleeding with biopsy Systemic use in the last two weeks or anticipated use during the study of any

2016 Clinical Trials

60. The Effect of New-style Vaginal Repair Mesh in the Treatment of Female Stress Urinary Incontinence

were made by Gynemech TM PS, (Johnson & Johnson Shanghai Medical Equipment Co. SFDA registration No. 3460365, size 10 × 15cm) Outcome Measures Go to Primary Outcome Measures : Anatomy of female perineal bilateral pubic bones [ Time Frame: Two months before treatment ] Anatomy of the main parameters of bilateral gap: female perineum pubis bilateral acupoint location, angle, length and width of the acupuncture points. Anatomy of female perineal bilateral pubic bones [ Time Frame: One month after (...) treatment ] Anatomy of the main parameters of bilateral gap: female perineum pubis bilateral acupoint location, angle, length and width of the acupuncture points. Incontinence questionnaire summary table observation [ Time Frame: Three months before treatment ] Incontinence questionnaire summary observation to evaluate the therapeutic effect of the study on the implantation of mesh in female stress urinary incontinence. If there are complications, including the cough so, sneezing or laughing

2016 Clinical Trials

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