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Vulvar Pruritus

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1. Vulvar Pruritus

Vulvar Pruritus Vulvar Pruritus Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Vulvar Pruritus Vulvar Pruritus Aka: Vulvar Pruritus (...) , Pruritus Vulvae , Vulvar Itching , Vulvar Itch From Related Chapters II. Definition Vulvar Itching III. Causes: Prepubertal Girls Poor hygiene s (uncommon in prepubertal girls) IV. Causes: Young women or infection or rarely (associated with burning pain) pubis or Other causes (HPV) Mechanical V. Causes: Post-menopausal women Includes causes seen in young women of the vulva ( ) VI. Evaluation Biopsy atypical vulvar lesions (rule-out cancer) VII. Management: Prevention Treat specific causes Use loose

2018 FP Notebook

2. Ospemifene (Senshio) - vulvar and vaginal atrophy (VVA)

, the number of discontinuations due to vasomotor AEs was relatively low (1.3%). , 8 Summary of clinical effectiveness issues VVA is a common, chronic condition that commonly affects post-menopausal women. A decline in oestrogen causes a decrease in vaginal lubrication, which can lead to a variety of symptoms such as burning, dyspareunia (pain associated with sexual activity), leukorrhea, vulvar pruritus, and a feeling of pressure and bleeding (particularly associated with sexual activity). In addition (...) Ospemifene (Senshio) - vulvar and vaginal atrophy (VVA) 1 Published 9 September 2019 1 SMC2170 ospemifene 60mg film-coated tablets (Senshio®) Shionogi Ltd 9 August 2019 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHSScotland. The advice is summarised as follows: ADVICE: following a full submission ospemifene (Senshio ® ) accepted for use within NHSScotland

2019 Scottish Medicines Consortium

3. Management of Vulvar Intraepithelial Neoplasia

on immunosuppression after organ transplant may need biopsy of lesions when the level of suspicion is lower. Colposcopy, or other forms of magnification of the vulva, can be useful in determining the extent of disease if lesions are not visible or not clearly demarcated in women with persistent focal vulvar pruritus and pain with no gross lesions, and women who remain symptomatic despite appropriate treatment for presumed vulvo-vaginitis. It should be performed after applying 3–5% acetic acid to the vulva (...) Management of Vulvar Intraepithelial Neoplasia Management of Vulvar Intraepithelial Neoplasia - ACOG Menu ▼ Management of Vulvar Intraepithelial Neoplasia Page Navigation ▼ A correction was published in January 2017 for this title. Click to view the correction. Number 675, October 2016 (Replaces Committee Opinion Number 509, November 2011) (Reaffirmed 2019) Committee on Gynecologic Practice American Society for Colposcopy and Cervical Pathology This Committee Opinion was developed

2016 American College of Obstetricians and Gynecologists

4. Vulvar pruritus in a postmenopausal woman (PubMed)

Vulvar pruritus in a postmenopausal woman 24549132 2014 08 26 2018 12 02 1488-2329 186 9 2014 Jun 10 CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne CMAJ Vulvar pruritus in a postmenopausal woman. 688-9 10.1503/cmaj.130665 Caro-Bruce Emily E Family Medicine, Kaiser Permanente, Vallejo, Calif. emily.x.caro-bruce@kp.org gabriel.flaxman@kp.org. Flaxman Gabriel G Family Medicine, Kaiser Permanente, Vallejo, Calif. eng Case Reports Journal Article Review (...) 2014 02 18 Canada CMAJ 9711805 0820-3946 AIM IM Biopsy Chronic Disease Cognitive Behavioral Therapy methods Diagnosis, Differential Female Humans Middle Aged Photochemotherapy methods Postmenopause Pruritus Vulvae diagnosis therapy 2014 2 20 6 0 2014 2 20 6 0 2014 8 27 6 0 ppublish 24549132 cmaj.130665 10.1503/cmaj.130665 PMC4049992 Am Fam Physician. 2008 Feb 1;77(3):321-6 18297956 Dermatol Clin. 2010 Oct;28(4):707-15 20883914 Br J Dermatol. 2013 Jun;168(6):1316-24 23398459 J Am Acad Dermatol. 2012

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2014 CMAJ : Canadian Medical Association Journal

5. Adjuvant Therapy in Vulvar Cancer

Therapy in Vulvar Cancer Clinical Condition: Adjuvant Therapy in Vulvar Cancer Variant 2: 65-year-old woman presented with significant vulvar pruritus from a 2-cm lesion arising from the left labia minora and approaching the urethra. She had no urinary complaints. No palpable inguinal lymph nodes. CT pelvis was negative for any lymphadenopathy in the groins or pelvis. She underwent wide local excision and sentinel lymph node dissection. Pathology revealed 2.4-cm squamous cell carcinoma with a close (...) Adjuvant Therapy in Vulvar Cancer Date of origin: 2015 ACR Appropriateness Criteria ® 1 Adjuvant Therapy in Vulvar Cancer American College of Radiology ACR Appropriateness Criteria ® ADJUVANT THERAPY IN VULVAR CANCER Expert Panel on Radiation Oncology – Gynecology: Shruti Jolly, MD 1 ; Payal Soni, MD 2 ; David K. Gaffney, MD, PhD 3 ; Matthew Biagioli, MD 4 ; Mohamed A. Elshaikh, MD 5 ; Anuja Jhingran, MD 6 ; Elizabeth Kidd, MD 7 ; Larissa J. Lee, MD 8 ; Linna Li, MD 9 ; David H. Moore, MD 10

2015 American College of Radiology

6. Diagnosis and Treatment of Vulvar Dermatoses. (PubMed)

Diagnosis and Treatment of Vulvar Dermatoses. Vulvar symptoms of pain, dyspareunia, and pruritus are common and may significantly affect a woman's sense of well-being and sexual function. Despite this, vulvar symptoms are often underreported by women. When identified, however, vulvovaginal symptoms should be addressed by health care providers to optimize care. The evaluation of patients with vulvovaginal complaints begins with a thorough history and physical examination. Biopsy is indicated (...) when concern exists for malignancy or the diagnosis is uncertain. Treatment, if possible, should be evidence-based, although for many vulvar disorders including vulvar dermatoses, treatment is based on limited evidence and anecdotal experience. Although many vulvar dermatoses represent chronic conditions and thus cannot be simply cured, control is possible for the majority of women. Patient education regarding vulvar hygiene and skin care is the foundation for optimal management of inflammatory

2018 Obstetrics and Gynecology

7. MonaLisa Touch Laser for the Treatment of Vulvar Lichen Sclerosus

finding include hyperkeratosis of the epidermis, epidermal atrophy with loss of rete ridges, homogenization of the collagen in the upper dermis, and a lichenoid (band-like) inflammatory infiltrate in the dermis. While there is no known cure for LS, the current gold standard treatment is ultra-potent corticosteroids. When properly administered, topical ultra-potent corticosteroids help to resolve the symptoms of pruritus and burning and can prevent further vulvar scarring. In addition, proper treatment (...) , the stimulus of nerve endings was reduced, so the clinical manifestations of LS, such as intense vulvar pruritus and burning were improved. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 40 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Triple (Participant, Care Provider, Investigator) Primary Purpose: Treatment Official Title: A Double Blinded Sham Controlled Trial of Fractional CO2 Laser

2018 Clinical Trials

8. Platelet Rich Plasma (PRP) for Vulvar Lichen Sclerosus

Platelet Rich Plasma (PRP) for Vulvar Lichen Sclerosus Platelet Rich Plasma (PRP) for Vulvar Lichen Sclerosus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Platelet Rich Plasma (PRP) for Vulvar Lichen (...) Study Description Go to Brief Summary: Lichen sclerosus (LS) is a skin condition of the external genitals (vulva) of women. LS causes vulvar itching, pain, and burning. In addition, LS causes scarring of the vulva which may cause significant sexual dysfunction or pain. Lastly, 4-6% of women with LS will develop vulvar cancer. The current "gold standard" treatment for lichen sclerosus is potent steroids creams. When used correctly, steroid creams help to decrease the symptoms of itching and burning

2017 Clinical Trials

9. Therapeutic comparison between treatments for Vulvar Lichen Sclerosus: study protocol of a randomized prospective and controlled trial. (PubMed)

Therapeutic comparison between treatments for Vulvar Lichen Sclerosus: study protocol of a randomized prospective and controlled trial. Vulvar lichen sclerosus (VLS) is a lymphocyte-mediated disease of unknown etiology that can cause intense itching as well stenosis, hindering the evacuation and urination. It can also limit the sex life due to severe local pruritus, pain and dyspareunia (pain during sexual intercourse). The standard treatment for this disease is the use of topical

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2017 BMC Women's Health

10. Vulvar Pruritus

Vulvar Pruritus Vulvar Pruritus Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Vulvar Pruritus Vulvar Pruritus Aka: Vulvar Pruritus (...) , Pruritus Vulvae , Vulvar Itching , Vulvar Itch From Related Chapters II. Definition Vulvar Itching III. Causes: Prepubertal Girls Poor hygiene s (uncommon in prepubertal girls) IV. Causes: Young women or infection or rarely (associated with burning pain) pubis or Other causes (HPV) Mechanical V. Causes: Post-menopausal women Includes causes seen in young women of the vulva ( ) VI. Evaluation Biopsy atypical vulvar lesions (rule-out cancer) VII. Management: Prevention Treat specific causes Use loose

2015 FP Notebook

11. Platelet Rich Plasma Injections for Vulvar Lichen Sclerosus

into vulvar skin. There are no placebo, sham, or active comparator arms Biological: Autologous platelet rich plasma 5cc of autologous platelet rich plasma derived from 50cc of whole blood will be injected into vulvar skin. Outcome Measures Go to Primary Outcome Measures : Decrease in inflammation on post treatment biopsies [ Time Frame: 14 weeks ] Pathologist will grade inflammation on 0-4 scale of pre and post treatment biopsies Secondary Outcome Measures : Decrease in Pruritus [ Time Frame: 14 weeks (...) Platelet Rich Plasma Injections for Vulvar Lichen Sclerosus Platelet Rich Plasma Injections for Vulvar Lichen Sclerosus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Platelet Rich Plasma Injections

2016 Clinical Trials

12. Vulvar Lichen Sclerosus

Vulvar Lichen Sclerosus Vulvar Lichen Sclerosus Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Vulvar Lichen Sclerosus Vulvar Lichen (...) Sclerosus Aka: Vulvar Lichen Sclerosus From Related Chapters II. Definition Idiopathic (possibly autoimmune), chronic inflammatory condition of peri-mucosal skin Most often affects vulva, but can also affect peri-anal skin and foreskin in men III. Symptoms Asymptomatic in one third of patients (may be severe enough to interfere with sleep) Painful (if s present) IV. Signs Initial are thick and white Labia minora may be edematous and partially resorbed Later are thin, wrinkled and hypopigmented (like

2018 FP Notebook

13. Safety and efficacy of human fibroblast lysate cream for vulvar lichen sclerosus: a randomized placebo-controlled trial. (PubMed)

Fibroblasts Humans Pilot Projects Pruritus Vulvae diagnosis drug therapy Remission Induction Skin Cream Time Factors Treatment Outcome Vulva drug effects pathology Vulvar Lichen Sclerosus diagnosis drug therapy 2015 1 31 6 0 2015 1 31 6 0 2016 8 5 6 0 ppublish 25634582 10.2340/00015555-2052 (...) Safety and efficacy of human fibroblast lysate cream for vulvar lichen sclerosus: a randomized placebo-controlled trial. 25634582 2016 08 04 2015 10 06 1651-2057 95 7 2015 Sep Acta dermato-venereologica Acta Derm. Venereol. Safety and efficacy of human fibroblast lysate cream for vulvar lichen sclerosus: a randomized placebo-controlled trial. 847-9 10.2340/00015555-2052 Goldstein Andrew T AT The Center for Vulvovaginal Disorders, The George Washington University School of Medicine, Department

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2016 Acta Dermato-Venereologica

14. The Impact of Inflammatory and Infectious Diseases of Vulvar on Quality of Life (PubMed)

The Impact of Inflammatory and Infectious Diseases of Vulvar on Quality of Life This study aimed to evaluate the effects of vulvar dermatoses (VD) and vulvar infections (VE) on anxiety, depression scores, general, and dermatological quality of life (QOL) of women.We conducted a cross-sectional survey on patients diagnosed with VD and VE. All patients were assessed using a sociodemographic form, Skindex-29 scale, World Health Organization QOL (WHOQOL) BREF scale, Hamilton anxiety rating scale (...) (HAM-A), Hamilton depression rating scale (HAM-D).HAM-A score was significantly higher in the VD group than in the control group. Based on age groups, all subscales of Skindex-29 were found to be higher in women > 50 years. For women with severe pruritus, the symptom subscale was higher in patients with skin involvement and the function and emotion subscales were higher in patients with and emotion subscales were higher in patients with mucosal involvement.We found that VD was particularly

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2016 Journal of Menopausal Medicine

15. Complete Peri-Vulvar and Peri-Anal Neurotomy For Intractable Pruritus Vulvae and Ani (PubMed)

Complete Peri-Vulvar and Peri-Anal Neurotomy For Intractable Pruritus Vulvae and Ani 14011034 1998 11 01 2018 12 01 0027-9684 54 1962 Nov Journal of the National Medical Association J Natl Med Assoc Complete peri-vulvar and peri-anal neurotomy for intractable pruritus vulvae and ani. 696-8 ADAMSON G N GN eng Journal Article United States J Natl Med Assoc 7503090 0027-9684 OM Female Humans Neurosurgery Pruritus Ani Pruritus Vulvae NEUROSURGERY PRURITUS ANI PRURITUS VULVAE 1962 11 1 1962 11 1 0 1

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1962 Journal of the National Medical Association

16. Clinical features and treatment of vulvar Merkel cell carcinoma: a systematic review. (PubMed)

with a firm, mobile vulvar mass. Symptoms of pain, erythema, pruritus, edema, and ulceration have been reported. Tumor histology is consistent with that of neuroendocrine tumors and typical Merkel cell carcinomas. Neuroendocrine and cytokeratin immunostains are frequently utilized in histopathological workup. Surgical management was the unanimous first-line therapy with adjuvant radiation in most cases. Recurrence occurred in 70.6% of patients at a mean follow-up of 6.3 months. Mortality was at 47.0 (...) Clinical features and treatment of vulvar Merkel cell carcinoma: a systematic review. Merkel cell carcinoma is a rare and aggressive neoplasm originating from mechanoreceptor Merkel cells of the stratum basale of the epidermis. Cases affecting the vulva are exceedingly rare, with the currently available literature primarily in case report form.Systematic review of the PubMed database returned 17 cases of Merkel cell carcinoma affecting the vulva. Patients presented at a mean age of 59.6 years

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2017 Gynecologic oncology research and practice

17. Effectiveness and Tolerability of LabiaStick#01 in Subjects With Symptomatic Non-hypertrophic Chronic Vulvar Dermatoses

vulvar dermatoses. Condition or disease Intervention/treatment Phase Chronic Disease of Skin Device: LabiaStick#01 Not Applicable Detailed Description: Vulvar dermatoses are skin disorders that affect the vulva, causing pruritus, irritation and pain. Although the prevalence of these disorders is unknown, it is well accepted that the vulvar symptoms are a common problem for women. LabiaStick#01 has emollient agents whose main function is to increase the skin hydration, provide physical protection (...) and decrease the symptoms and possibility of recurrence of vulvar dermatoses. The medical device should be applied once daily, in the evening, after intimal hygiene care. The primary objective of this study is to evaluate the effectiveness of LabiaStick#01 on the relief of pruritus caused by symptomatic non-hypertrophic chronic vulvar dermatoses. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 3 participants Intervention Model: Single

2015 Clinical Trials

18. Vulvar Lichen Sclerosus: Comparison Between Clobetasol Propionate, Photodynamic Therapy and Low-Intensity Laser

Vulvar Lichen Sclerosus: Comparison Between Clobetasol Propionate, Photodynamic Therapy and Low-Intensity Laser Vulvar Lichen Sclerosus: Comparison Between Clobetasol Propionate, Photodynamic Therapy and Low-Intensity Laser - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Vulvar Lichen Sclerosus: Comparison Between Clobetasol Propionate, Photodynamic Therapy and Low-Intensity Laser (VLSCBCPPTLIL) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02416531 Recruitment Status : Completed First Posted

2015 Clinical Trials

19. UV-A1 Phototherapy vs Clobetasol Propionate, 0.05%, in the Treatment of Vulvar Lichen Sclerosus: A Randomized Clinical Trial. (PubMed)

UV-A1 Phototherapy vs Clobetasol Propionate, 0.05%, in the Treatment of Vulvar Lichen Sclerosus: A Randomized Clinical Trial. Topical corticosteroids are the current first-line therapy for vulvar lichen sclerosus (VLS). UV-A1 phototherapy may be a promising alternative treatment option, but controlled studies are lacking.To compare the efficacy of high-potent topical corticosteroids with UV-A1 phototherapy in the treatment of VLS.A 2-arm randomized clinical trial was conducted at a university (...) the reduction of pruritus and burning and/or pain according to a visual analog scale (VAS), a health-related quality of life score (Skindex-29), 20-MHz ultrasonography, and histopathological analysis before and after 3 months of therapy.Fifteen patients were randomized in each treatment arm, and 2 patients dropped out in both treatment arms. After therapy, both therapies resulted in a significant decrease in mean TCS (51.4% [95% CI, 39.7% to 63.0%] for clobetasol ointment [P < .001] and 35.6% [95% CI, 18.2

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2014 JAMA dermatology (Chicago, Ill.)

20. Key concepts in management of vulvar cancer. (PubMed)

Key concepts in management of vulvar cancer. Vulvar carcinoma is an uncommon tumor that is seen most often in older women. Subtle symptoms such as pruritus should prompt examination and targeted biopsy in all women as this disease can be successfully treated even in elderly, frail individuals. Vulvar cancer has a bimodal age distribution and is seen in both young and older women with risk factors including human papillomavirus (HPV) infection, smoking, and vulvar skin diseases (i.e., lichen (...) sclerosus). This cancer is staged surgically, with an update in 2009 incorporating prognostic factors. The treatment of vulvar carcinoma has evolved to include more conservative surgical techniques that provide improved cure rates with emphasis on minimizing morbidity. Advanced and metastatic lesions are now treated with chemoradiation which produces substantial cure rates with decreased morbidity. Promising areas of research in vulvar cancer include refinement of sentinel lymph node biopsy, prevention

2014 Best practice & research. Clinical obstetrics & gynaecology

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