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Vulvar Lichen Sclerosus

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1. Treatment alternatives for vulvar lichen sclerosus: a systematic review and armed based network meta-analysis

Treatment alternatives for vulvar lichen sclerosus: a systematic review and armed based network meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

2. Carcinome épidermoïde sur lichen scléro-atrophique vulvaire: Epidermoid carcinoma associated with atrophic vulvar lichen sclerosus (PubMed)

Carcinome épidermoïde sur lichen scléro-atrophique vulvaire: Epidermoid carcinoma associated with atrophic vulvar lichen sclerosus We here report the case of a 58-year old female patient with no particular past medical history, presenting with a 5-year history of vulvar pruritis, drought and vulvodynia at the Department of Dermatology. Clinical examination showed diffuse porcelaine lesions at the level of the vulva, with a yellowish hemispheric nodular lesion measuring 1 cm in diameter (...) on the whitish plates and some excoriated lesions due to scratching. A skin biopsy was performed at the level of the whitish lesions and at the level of the nodular lesion. Histological examination suggested epidermoid carcinoma for the budding lesion and atrophic vulvar lichen sclerosus for the porcelaine lesions. Surgical treatment was recommended associated with radiation therapy. This study aims to highlight the risk for atrophic vulvar lichen sclerosu degeneration.

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2018 The Pan African medical journal

3. A randomized double-blind placebo-controlled trial of autologous platelet-rich plasma intradermal injections for the treatment of vulvar lichen sclerosus. (PubMed)

A randomized double-blind placebo-controlled trial of autologous platelet-rich plasma intradermal injections for the treatment of vulvar lichen sclerosus. 30639885 2019 02 09 1097-6787 2019 Jan 11 Journal of the American Academy of Dermatology J. Am. Acad. Dermatol. A randomized double-blind placebo-controlled trial of autologous platelet-rich plasma intradermal injections for the treatment of vulvar lichen sclerosus. S0190-9622(19)30066-0 10.1016/j.jaad.2018.12.060 Goldstein Andrew T AT Center

2019 Journal of the American Academy of Dermatology

4. The long-term clinical consequences of Juvenile Vulvar Lichen Sclerosus, a systematic review. (PubMed)

The long-term clinical consequences of Juvenile Vulvar Lichen Sclerosus, a systematic review. Vulvar lichen sclerosus (VLS) occurring in juveniles (children and adolescents) may have repercussions throughout life.We sought to assess the evidence available on the long-term consequences of juvenile vulvar lichen sclerosus (JVLS).Multiple databases were searched for studies containing long-term follow-up information on children or adolescents up to age 18 with VLS. Articles were classified (...) of malignancy. The included publications had low-level evidence.Meta-analysis was not possible due to different focus of the studies. Very few subjects were followed into adulthood.There is low-level evidence suggesting long-term repercussions of JVLS. Studies following juveniles with VLS into adulthood are needed in order to better understand the course of this disease and its repercussions on adult vulvar health.Copyright © 2019. Published by Elsevier Inc.

2019 Journal of American Academy of Dermatology

5. Vulvar Neoplasms in 275 Women With Genital Lichen Sclerosus and Impact of Treatment: A Retrospective Chart Review. (PubMed)

Vulvar Neoplasms in 275 Women With Genital Lichen Sclerosus and Impact of Treatment: A Retrospective Chart Review. 29524285 2018 08 23 1468-3083 32 9 2018 Sep Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Vulvar neoplasms in 275 women with genital lichen sclerosus and impact of treatment: a retrospective chart review. e363-e365 10.1111/jdv.14938 Dell E A EA Department of Dermatology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA

2018 Journal of the European Academy of Dermatology and Venereology

6. Diagnosis and Treatment of Vulvar Lichen Sclerosus: An Update for Dermatologists. (PubMed)

Diagnosis and Treatment of Vulvar Lichen Sclerosus: An Update for Dermatologists. Vulvar lichen sclerosus is an important skin disease that is common in women in their 50 s and beyond; however, it can also affect females of any age, including children. If not treated, it has the potential to cause significant and permanent scarring and deformity of the vulvar structure. In addition, if untreated, it is associated with a 2-6% lifetime risk of malignant squamous neoplasia of the vulva. Lichen (...) sclerosus has been considered a difficult to manage condition; however, both serious complications can potentially be prevented with early intervention with topical corticosteroid, suggesting that the course of the disease can be treatment modified.

2018 American journal of clinical dermatology

7. Association of Retinoic Acid Receptor β Gene With Onset and Progression of Lichen Sclerosus-Associated Vulvar Squamous Cell Carcinoma. (PubMed)

Association of Retinoic Acid Receptor β Gene With Onset and Progression of Lichen Sclerosus-Associated Vulvar Squamous Cell Carcinoma. Molecular alterations in lichen sclerosus-associated vulvar squamous cell carcinoma (LS-VSCC) are largely unknown.To determine whether the retinoic acid receptor β (RARβ) tumor-suppressor gene is involved in the onset and/or progression of LS-VSCC.The case-control study, conducted at University-Hospital of Ferrara, Italy, included 20 LS-VSCC (mean [SD] age, 75 (...) [3] years) and 20 cancer-associated vulvar LS (caVLS; mean [SD] age, 62 [11] years) formalin-fixed embedded tissue specimens, 20 cancer-free vulvar LS (cfVLS), and 20 normal skin fresh specimens from diagnostic biopsies and women surgically treated for nonmalignant skin lesions, respectively. RARβ gene expression and promoter methylation were investigated in LS-VSCC and caVLS adjacent to VSCC specimens, and in cfVLS and normal skin specimens, as controls, by RT-Q real-time polymerase chain

2018 JAMA dermatology (Chicago, Ill.)

8. Differentiated Vulvar Intraepithelial Neoplasia-like and Lichen Sclerosus-like Lesions in HPV-associated Squamous Cell Carcinomas of the Vulva. (PubMed)

Differentiated Vulvar Intraepithelial Neoplasia-like and Lichen Sclerosus-like Lesions in HPV-associated Squamous Cell Carcinomas of the Vulva. Most human papillomavirus (HPV)-associated vulvar squamous cell carcinomas (VSCCs) originate from high-grade squamous intraepithelial lesions, also named usual type vulvar intraepithelial neoplasia. However, growing evidence suggests that morphologic studies have limitations in predicting HPV status in vulvar lesions. We aimed to evaluate adjacent (...) intraepithelial lesions in a series of DNA HPV-positive VSCCs, focusing on unusual histologic patterns mimicking differentiated vulvar intraepithelial neoplasia (dVIN) or lichen sclerosus (LS). We identified 326 DNA HPV-positive VSCC with at least 1 cm of skin adjacent to the invasive tumor and analyzed HPV typing, HPV E6*I mRNA, and p16 immunohistochemistry in all cases. A careful histologic evaluation was conducted. A conclusive association with HPV was based on a positive p16 or HPV E6*I mRNA result

2018 American Journal of Surgical Pathology

9. Platelet-rich plasma (PRP) for the treatment of vulvar lichen sclerosus in a premenopausal woman: A case report (PubMed)

Platelet-rich plasma (PRP) for the treatment of vulvar lichen sclerosus in a premenopausal woman: A case report The use of platelet-rich plasma (PRP) for the treatment of lichen sclerosus (LS) in a 38-year-old premenopausal woman is reported. The diagnosis was confirmed histologically and the symptoms documented using the ICIQ Vaginal Symptoms Questionnaire (ICIQ-VS) and the Female Sexual Function Index (FSFI) questionnaire. PRP was prepared from autologous blood using the Regen Cellular Matrix

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2018 Case Reports in Women's Health

10. Expression of galectin-7 in vulvar lichen sclerosus and its effect on dermal fibroblasts (PubMed)

Expression of galectin-7 in vulvar lichen sclerosus and its effect on dermal fibroblasts Lichen sclerosus is a chronic and inflammatory disease. Extensive studies have focused on the epidermis, with the dermis or epidermis-dermis receiving less attention. To investigate the role of galectin-7, a keratinocyte protein, in vulvar lichen sclerosus (VLS) and its potential effects on dermal fibroblasts, immunohistochemical staining was performed with VLS tissue samples and normal control samples (...) associated with the galectin-7 treatment concentration. The overexpression of galectin-7 is associated with the progression of VLS in the epidermis, a high concentration of galectin-7 inhibits the viability of the primary vulvar dermal fibroblasts, and stimulates the accumulation of collagen I and collagen III in dermal fibroblast cultures, thus galectin-7 may serve as a drug target during VLS progression.

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2018 Oncology letters

11. MonaLisa Touch Laser for the Treatment of Vulvar Lichen Sclerosus

MonaLisa Touch Laser for the Treatment of Vulvar Lichen Sclerosus MonaLisa Touch Laser for the Treatment of Vulvar Lichen Sclerosus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. MonaLisa Touch Laser (...) for the Treatment of Vulvar Lichen Sclerosus The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03665584 Recruitment Status : Recruiting First Posted : September 11, 2018 Last Update Posted : November 20, 2018 See Sponsor: Center

2018 Clinical Trials

12. Vulvar lichen sclerosus in a prepubertal girl (PubMed)

Vulvar lichen sclerosus in a prepubertal girl 30443372 2019 02 26 2053-8855 2018 12 2018 Dec Oxford medical case reports Oxf Med Case Reports Vulvar lichen sclerosus in a prepubertal girl. omy104 10.1093/omcr/omy104 Rodrigues Alexandra A Paediatrics Department, Hospital Dr. Nélio Mendonça, Funchal, Portugal. Cabral António Jorge AJ Paediatrics Department, Hospital Dr. Nélio Mendonça, Funchal, Portugal. Faria Anabela A Dermatology Department, Hospital Dr. Nélio Mendonça, Funchal, Portugal

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2018 Oxford Medical Case Reports

13. British Association of Dermatologists' guidelines for the management of lichen sclerosus

British Association of Dermatologists' guidelines for the management of lichen sclerosus GUIDELINE BJD British Journal of Dermatology British Association of Dermatologists guidelines for the management of lichen sclerosus, 2018* F.M. Lewis iD, 1,2 F.M. Tatnall, 3 S.S. Velangi, 4 C.B. Bunker, 5,6 A. Kumar, 7 F. Brackenbury, 8 M.F. Mohd Mustapa 9 and L.S. Exton 9 1 Frimley Health NHS Foundation Trust, Slough SL2 4HL, U.K. 2 St John’s Institute of Dermatology, Guy’s & St Thomas’ NHS Foundation (...) Trust, London SE1 9RT, U.K. 3 West Hertfordshire NHS Trust, Watford WD18 0HB, U.K. 4 University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2TH, U.K. 5 University College London Hospitals NHS Foundation Trust, University College Hospital, London NW1 2BU, U.K. 6 Chelsea & Westminster NHS Foundation Trust, London SW10 9NH, U.K. 7 King’s College London, London SE1 3ER, U.K. 8 Association for Lichen Sclerosus and Vulval Health, Brighton, U.K. 9 British Association of Dermatologists, Willan

2018 British Association of Dermatologists

14. Comparison of 5-Aminolevulinic Acid Photodynamic Therapy and Clobetasol Propionate in Treatment of Vulvar Lichen Sclerosus. (PubMed)

Comparison of 5-Aminolevulinic Acid Photodynamic Therapy and Clobetasol Propionate in Treatment of Vulvar Lichen Sclerosus. The aim of this study was to evaluate the effectiveness of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) for the treatment of vulvar lichen sclerosus (VLS) and compare its effectiveness with that of clobetasol propionate. Four sessions of topical photodynamic therapy (PDT) were administered at 2-week intervals (n = 20). Clobetasol propionate (0.05%) was used daily

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2017 Acta Dermato-Venereologica

15. Platelet Rich Plasma (PRP) for Vulvar Lichen Sclerosus

Platelet Rich Plasma (PRP) for Vulvar Lichen Sclerosus Platelet Rich Plasma (PRP) for Vulvar Lichen Sclerosus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Platelet Rich Plasma (PRP) for Vulvar Lichen (...) Study Description Go to Brief Summary: Lichen sclerosus (LS) is a skin condition of the external genitals (vulva) of women. LS causes vulvar itching, pain, and burning. In addition, LS causes scarring of the vulva which may cause significant sexual dysfunction or pain. Lastly, 4-6% of women with LS will develop vulvar cancer. The current "gold standard" treatment for lichen sclerosus is potent steroids creams. When used correctly, steroid creams help to decrease the symptoms of itching and burning

2017 Clinical Trials

16. Fractional / Pixel CO2 Laser Treatment of Vulvar Atrophy and Lichen Sclerosus

Fractional / Pixel CO2 Laser Treatment of Vulvar Atrophy and Lichen Sclerosus Fractional / Pixel CO2 Laser Treatment of Vulvar Atrophy and Lichen Sclerosus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Fractional / Pixel CO2 Laser Treatment of Vulvar Atrophy and Lichen Sclerosus The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03063684 Recruitment Status : Active, not recruiting First Posted : February 24, 2017 Last Update Posted : February 21, 2019 Sponsor: Hadassah Medical Organization Information

2017 Clinical Trials

17. Therapeutic comparison between treatments for Vulvar Lichen Sclerosus: study protocol of a randomized prospective and controlled trial. (PubMed)

Therapeutic comparison between treatments for Vulvar Lichen Sclerosus: study protocol of a randomized prospective and controlled trial. Vulvar lichen sclerosus (VLS) is a lymphocyte-mediated disease of unknown etiology that can cause intense itching as well stenosis, hindering the evacuation and urination. It can also limit the sex life due to severe local pruritus, pain and dyspareunia (pain during sexual intercourse). The standard treatment for this disease is the use of topical

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2017 BMC Women's Health

18. Clearance in vulvar lichen sclerosus: a realistic treatment endpoint or a chimera? (PubMed)

Clearance in vulvar lichen sclerosus: a realistic treatment endpoint or a chimera? According to the current guidelines, the aim of vulvar lichen sclerosus (VLS) treatment was to improve symptoms and signs, not to cure.To assess (i) the rate of patients with VLS who achieved complete clearance of symptoms or objective features, or both, with a 12-week pharmacological treatment and (ii) the predictive value of therapeutic response to the demographic and clinical features.We retrospectively

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2017 Journal of the European Academy of Dermatology and Venereology

19. Mometasone furoate in the treatment of vulvar lichen sclerosus: could its formulation influence efficacy, tolerability and adherence to treatment? (PubMed)

Mometasone furoate in the treatment of vulvar lichen sclerosus: could its formulation influence efficacy, tolerability and adherence to treatment? To assess the effectiveness, tolerability, and convenience of the cream formulation of mometasone furoate 0.1% (MMF) in the treatment of active vulvar lichen sclerosus (VLS) and to compare the cream with the ointment formulation.The following efficacy parameters were assessed in 27 VLS patients treated with MMF cream for 12 weeks (group A): (i

2017 Journal of Dermatological Treatment

20. Photodynamic Therapy for Vulvar Lichen Sclerosus-A Systematic Review.

Photodynamic Therapy for Vulvar Lichen Sclerosus-A Systematic Review. Lichen sclerosus (LS) is a disease affecting mostly genital and perianal areas. Photodynamic therapy (PDT) has gained interest during the past years. The present study accumulates current evidence on the efficacy of PDT in the management of vulvar LS.We used Medline (1966-2017), Scopus (2004-2017), ClinicalTrials.gov (2008-2017) and Cochrane Central Register of Controlled Trials CENTRAL (1999-2017) databases in our primary (...) , as current data do not unanimously support a beneficial histological effect.According to the findings of our study, PDT seems to be promising in the treatment of patients with vulvar LS. Nonetheless, current knowledge is extremely limited, and further observational studies with large patient series are needed in the field to elucidate the efficacy of PDT.

2017 Journal of lower genital tract disease

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