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Vulvar Lichen Planus

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1. Vulvar lichen planus pemphigoides (PubMed)

Vulvar lichen planus pemphigoides Lichen planus pemphigoides (LPP) is a rare blistering disease with features of both lichen planus and bullous pemphigoid. LPP typically appears on the extremities and occasionally involves the oral mucosa. Herein, we describe a case of LPP of the vulva of an 80-year-old woman, an uncommon location for this disease process. This clinical scenario can be confused with a number of similarly appearing entities such as erosive vulvar lichen planus, mucous membrane (...) pemphigoid, and erosive lichen sclerosus et atrophicus. In fact, our patient carried a diagnosis of lichen sclerosus by an outside physician for 2 years prior to being properly diagnosed and treated. A detailed discussion of the epidemiology, clinical, and pathogenesis as well as the histologic and immunofluorescence characteristics of this uncommon diagnosis is presented. Our case emphasizes the necessity of microscopic analysis to differentiate lookalike disease states when making a diagnosis

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2017 International journal of women's dermatology

2. Vulvar Lichen Planus

Vulvar Lichen Planus Vulvar Lichen Planus Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Vulvar Lichen Planus Vulvar Lichen Planus (...) Aka: Vulvar Lichen Planus , Lichen Planus of the Vulva , Vulvovaginal-Gingival Syndrome From Related Chapters II. Definition Autoimmune inflammatory condition that affects keratinized areas including vulva III. Epidemiology Affects patients between ages 30 to 60 years Much less common than as a cause for IV. Types Erosive (most common variant) Glassy appearing white s and s Progression to ulcers and erosions with altered Vagina involved in 70% of cases (vagina not involved in ) characterized

2018 FP Notebook

3. Vulvar cancers in women with vulvar lichen planus: A clinicopathological study. (PubMed)

Vulvar cancers in women with vulvar lichen planus: A clinicopathological study. Vulvar squamous cell carcinomas (SCCs) arising in association with vulvar lichen planus (LP) are poorly documented.We sought to present clinicopathological features of 38 patients (median age 61 years, range 39-90 years) with LP-associated vulvar SCCs.Evaluated were location of vulvar SCC and metastases at presentation, recurrences, survival, precursor lesions, presence of human papillomavirus DNA, p16ink4a, and p53 (...) SCCs in the residual diseased mucosa. Of all recurrences, 68% developed within 12 months via precursors revealing various histologic features including elongated, but also flat rete ridges, basaloid and hypertrophic differentiation with inconsistent p53 expression. Fourteen of 38 (37%) patients died of SCCs.Retrospective study and lack of a standardized treatment protocols are limitations.LP-associated SCCs were located in nonhair-bearing vulvar mucosa. Patients had a high rate of inguinal

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2014 Journal of American Academy of Dermatology

4. THE AP-GELP STUDY: A Clinical Trial on the Effects of Apremilast in Female Genital Erosive Lichen Planus

THE AP-GELP STUDY: A Clinical Trial on the Effects of Apremilast in Female Genital Erosive Lichen Planus THE AP-GELP STUDY: A Clinical Trial on the Effects of Apremilast in Female Genital Erosive Lichen Planus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. THE AP-GELP STUDY: A Clinical Trial on the Effects of Apremilast in Female Genital Erosive Lichen Planus The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03656666

2018 Clinical Trials

5. Is Vulvovaginal Lichen Planus Associated With Squamous Cell Carcinoma? (PubMed)

Is Vulvovaginal Lichen Planus Associated With Squamous Cell Carcinoma? The aim of the study was to assess for the presence of vulvar lichen planus (LP) in association with human papillomavirus (HPV)-independent squamous cell carcinoma (SCC).We performed a clinicohistopathologic review of consecutive vulvectomies and wide local excisions for HPV-independent vulvar or vaginal SCC from 2007 to 2017. Data collected included site of SCC, adjacent precursor lesions and dermatoses, dermatologic (...) , 1 had a nonspecific lichenoid reaction, and 1 had lichen simplex; both of the latter had subsequent biopsies showing LS. Lichen planus was not seen in association with SCC. Differentiated vulvar intraepithelial neoplasia (dVIN) was present in 38 (88%) of 43 specimens, whereas 1 had acanthosis with altered differentiation and 4 (9%) had no precursor lesion. Differentiated vulvar intraepithelial neoplasia had standard, basaloid, and hypertrophic morphology, superficially resembling erosive LP in 9

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2018 Journal of lower genital tract disease

6. MonaLisa Touch Laser for the Treatment of Vulvar Lichen Sclerosus

, molluscum, condyloma). Have been diagnosed with other vulvar dermatologic conditions including lichen planus, psoriasis, lichen simplex chronicus, candidiasis, intraepithelial neoplasia, or carcinoma. Are pregnant or breastfeeding. If you become pregnant while on the study, you must withdraw from the study. Have received an investigational drug within four weeks prior to the study or who plan to use other investigational drugs during the course of this study. Have severe medical condition(s (...) MonaLisa Touch Laser for the Treatment of Vulvar Lichen Sclerosus MonaLisa Touch Laser for the Treatment of Vulvar Lichen Sclerosus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. MonaLisa Touch Laser

2018 Clinical Trials

7. Platelet Rich Plasma (PRP) for Vulvar Lichen Sclerosus

lichen sclerosus will be recruited from one center. This study will consist of a two-week screening period and a 12-week treatment period. At the beginning of the screening period, a 4 millimeter punch skin biopsy sample will be collected from each patient to confirm the diagnosis of active lichen sclerosus and to rule out the diagnoses of lichen planus, psoriasis, candidiasis, and vulvar intraepithelial neoplasia. In addition, vulvoscopy will be performed at the screening visit and after the 12-week (...) Platelet Rich Plasma (PRP) for Vulvar Lichen Sclerosus Platelet Rich Plasma (PRP) for Vulvar Lichen Sclerosus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Platelet Rich Plasma (PRP) for Vulvar Lichen

2017 Clinical Trials

8. British Association of Dermatologists' guidelines for the management of lichen sclerosus

’ are synonymous terms for LS and should not be used. The suf?x ‘et atrophicus’ has been dropped, as it is recognized that some cases of LS are associated with a hypertrophic, rather than atrophic, epithelium. The term ‘leukoplakia’ (meaning white plaque) is not a diagnostic entity and is descriptive only, as many conditions may present with white plaques. There are instances when it can be dif?cult to differentiate between LS and lichen planus (LP) on the basis of the clinical and histological features, 8 (...) British Association of Dermatologists' guidelines for the management of lichen sclerosus GUIDELINE BJD British Journal of Dermatology British Association of Dermatologists guidelines for the management of lichen sclerosus, 2018* F.M. Lewis iD, 1,2 F.M. Tatnall, 3 S.S. Velangi, 4 C.B. Bunker, 5,6 A. Kumar, 7 F. Brackenbury, 8 M.F. Mohd Mustapa 9 and L.S. Exton 9 1 Frimley Health NHS Foundation Trust, Slough SL2 4HL, U.K. 2 St John’s Institute of Dermatology, Guy’s & St Thomas’ NHS Foundation

2018 British Association of Dermatologists

9. Vulvar Verruciform Xanthoma: Ten Cases Associated With Lichen Sclerosus, Lichen Planus, or Other Conditions. (PubMed)

Vulvar Verruciform Xanthoma: Ten Cases Associated With Lichen Sclerosus, Lichen Planus, or Other Conditions. Verruciform xanthoma (VX) is a rare benign tumor that usually involves the oral cavity. Since the first report of this tumor in 1971, only 9 cases have been reported on the vulva, and 3 of these were associated with another vulvar condition. We describe the clinicopathologic features of 10 patients with vulvar VX and focus on their associated conditions.The mean age of the patients (...) was 68 years (range, 51-80 years). The VX lesions were asymptomatic, yellowish-orange verrucous plaques. The diagnosis was clinically suspected in 2 cases; other suggested diagnoses were condyloma or squamous cell carcinoma. All of the patients had an associated vulvar condition: lichen sclerosus (6 patients), lichen planus (2 patients), Paget disease, or radiodermatitis. Under microscopy, the VX lesions displayed parakeratosis, acanthosis without atypia, and elongated rete ridges. Xanthomatous cells

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2011 Archives of Dermatology

10. An Autoimmune Phenotype in Vulvar Lichen Sclerosus and Lichen Planus: A Th1 Response and High Levels of MicroRNA-155. (PubMed)

An Autoimmune Phenotype in Vulvar Lichen Sclerosus and Lichen Planus: A Th1 Response and High Levels of MicroRNA-155. Vulvar lichen sclerosus and lichen planus are T-cell-mediated chronic skin disorders. Although autoimmunity has been suggested, the exact pathogenesis of these disorders is still unknown. Therefore, the aim of the current study was to investigate the molecular and immunological mechanisms critical to the pathogenesis of vulvar lichen sclerosus and lichen planus. By using gene (...) response, with pronounced dermal infiltrates of CD4(+), CD8(+), and FOXP3(+) cells. In conclusion, these data demonstrate an autoimmune phenotype in vulvar lichen sclerosus and lichen planus, characterized by increased levels of Th1-specific cytokines, a dense T-cell infiltrate, and enhanced BIC/miR-155 expression.

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2011 Journal of Investigative Dermatology

11. Vulvar Lichen Planus

Vulvar Lichen Planus Vulvar Lichen Planus Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Vulvar Lichen Planus Vulvar Lichen Planus (...) Aka: Vulvar Lichen Planus , Lichen Planus of the Vulva , Vulvovaginal-Gingival Syndrome From Related Chapters II. Definition Autoimmune inflammatory condition that affects keratinized areas including vulva III. Epidemiology Affects patients between ages 30 to 60 years Much less common than as a cause for IV. Types Erosive (most common variant) Glassy appearing white s and s Progression to ulcers and erosions with altered Vagina involved in 70% of cases (vagina not involved in ) characterized

2015 FP Notebook

12. Persistent Vulvar Pain

of relevant visible findings or a specific, clinically identifiable, neurologic disorder ( ). Vulvodynia is not caused by a commonly identified infection (eg, candidiasis, human papillomavirus, herpes), inflammation (eg, lichen sclerosus, lichen planus, immunobullous disorder), neoplasia (eg, Paget disease, squamous cell carcinoma), or a neurologic disorder (eg, herpes neuralgia, spinal nerve compression). The newer consensus terminology notes that vulvar pain can be classified as vulvar pain caused (...) Persistent Vulvar Pain Persistent Vulvar Pain - ACOG Menu ▼ Persistent Vulvar Pain Page Navigation ▼ Number 673, September 2016 (Replaces Committee Opinion No. 345, October 2006) (Reaffirmed 2019) Committee on Gynecologic Practice This Committee Opinion was developed by the American College of Obstetricians and Gynecologists’ Committee on Gynecologic Practice and the American Society for Colposcopy and Cervical Pathology (ASCCP) in collaboration with committee member Ngozi Wexler, MD, MPH

2016 American College of Obstetricians and Gynecologists

13. Surgical Management of Vulvovaginal Agglutination Due to Lichen Planus. (PubMed)

Surgical Management of Vulvovaginal Agglutination Due to Lichen Planus. Lichen planus is a rare dermatological disorder that is often associated with painful and disfiguring vulvovaginal effects. At the University of Michigan Center for Vulvar Diseases, we see many women with vulvovaginal lichen planus each year, with marked scarring and vulvovaginal agglutination that precludes vaginal intercourse and causes difficulty with urination. Through our experience, we developed a protocol (...) for the operative management and postoperative care for severe vulvovaginal agglutination. Our objective is to share this protocol with a wider audience so that providers who see patients with these devastating effects of lichen planus can benefit from our experience to better serve this patient population. The figure represents a case of erosive lichen planus with early vaginal agglutination. The video reviews the pathophysiology and presentation of lichen planus. We then present a case of scarring

2015 American Journal of Obstetrics and Gynecology

14. Lichenoid vulvar disease: A review (PubMed)

Lichenoid vulvar disease: A review Vulvar dermatoses are common, potentially debilitating conditions that can be seen by a variety of medical specialists. Lichenoid vulvar diseases, namely lichen sclerosus (LS), lichen planus (LP), and lichen simplex chronicus (LSC), can all negatively impact patients' quality of life and LS and LP also have an association with squamous cell carcinoma. It is essential that dermatologists are familiar with the unique features of each of these conditions (...) to ensure the appropriate management and follow up. Herein, we provide an update on the epidemiology, clinical presentation, histopathology, and treatment of patients with vulvar LS, LP, and LSC.

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2017 International journal of women's dermatology

15. Biodistribution of protoporphyrin IX in female genital erosive lichen planus after topical application of hexaminolevulinate. (PubMed)

Biodistribution of protoporphyrin IX in female genital erosive lichen planus after topical application of hexaminolevulinate. Genital erosive lichen planus (GELP) is a chronic inflammatory disease, in women characterized by painful vulvar and vaginal erosions. To prepare for a clinical trial on photodynamic treatment (PDT), we applied hexyl 5-aminolevulinate hydrochloride (HAL) in clinically normal and affected mucosa in 12 women with GELP using two different doses (6.25 or 50mg/ml). Biopsies

2014 Photodiagnosis and photodynamic therapy

16. Clinical patterns of lichen planopilaris in patients with vulval lichen planus. (PubMed)

J Dermatol 0004041 0007-0963 IM Adult Aged Cohort Studies Female Humans Lichen Planus pathology Lichen Planus, Oral pathology Middle Aged Scalp Dermatoses pathology Vulvar Diseases pathology 2013 9 14 6 0 2013 9 14 6 0 2015 1 15 6 0 ppublish 24028504 10.1111/bjd.12609 (...) Clinical patterns of lichen planopilaris in patients with vulval lichen planus. 24028504 2015 01 14 2014 01 21 1365-2133 170 1 2014 Jan The British journal of dermatology Br. J. Dermatol. Clinical patterns of lichen planopilaris in patients with vulval lichen planus. 218-20 10.1111/bjd.12609 Chew A A St. John's Institute of Dermatology, St Thomas' Hospital, Westminster Bridge Road, London, SE1 7EH, U.K. Stefanato C M CM Savarese I I Neill S M SM Fenton D A DA Lewis F M FM eng Letter England Br

2013 British Journal of Dermatology

17. Lichen Planus (Diagnosis)

lesions in the mouth, particularly in men, do have a low rate of malignant transformation. However, the malignant transformation rate of oral lichen planus is low (< 2% in one report). [ ] Vulvar lesions in women may also be associated with squamous cell carcinoma. Previous Next: Patient Education Patients should be told about the self-limiting nature of lichen planus. Because lichen planus is not common, no large, randomized, controlled clinical trials have been conducted for therapy. Several (...) Lichen Planus (Diagnosis) Lichen Planus: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTEyMzIxMy1vdmVydmlldw== processing > Lichen Planus Updated: Jul 25, 2018

2014 eMedicine.com

18. Lichen Planus (Overview)

lesions in the mouth, particularly in men, do have a low rate of malignant transformation. However, the malignant transformation rate of oral lichen planus is low (< 2% in one report). [ ] Vulvar lesions in women may also be associated with squamous cell carcinoma. Previous Next: Patient Education Patients should be told about the self-limiting nature of lichen planus. Because lichen planus is not common, no large, randomized, controlled clinical trials have been conducted for therapy. Several (...) Lichen Planus (Overview) Lichen Planus: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTEyMzIxMy1vdmVydmlldw== processing > Lichen Planus Updated: Jul 25, 2018

2014 eMedicine.com

19. Topical Treatment for Sexual Pain, Vulvar Pain, in Postmenopausal Women Not Taking Estrogens or Similiar Hormones

dermatologic manifestations of herpes. Genital herpes and its accompanying genital pain may obscure the source of the genital pain experienced and confound the ability to determine the efficacy of treatment/placebo on endpoint of alleviation of pain in women with SPVD. Have any infection of the genitalia Have lichen sclerosis, lichen planus, contact dermatitis, psoriasis or any inflammatory condition or abrasions of the vulva Have an episiotomy scar in the area where pain is perceived as it may confound (...) Topical Treatment for Sexual Pain, Vulvar Pain, in Postmenopausal Women Not Taking Estrogens or Similiar Hormones Topical Treatment for Sexual Pain, Vulvar Pain, in Postmenopausal Women Not Taking Estrogens or Similiar Hormones. Women on Tamoxifen CAN Enter the Clinical Trial - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study

2018 Clinical Trials

20. Vaginal lichen sclerosus: report of two cases (PubMed)

Vaginal lichen sclerosus: report of two cases Lichen sclerosus most commonly affects the genital area. Contrarily to lichen planus, the involvement of the oral or vaginal mucosa is rare. Only four cases of vaginal lichen sclerosus have been described in the literature.The authors report two cases of postmenopausal women with a history of vulvar pruritus and burning. Both presented with lesions of the vaginal mucosa compatible with lichen sclerosus, and genital prolapse. Vaginal biopsies (...) confirmed the diagnosis. Initial treatment with topical clobetasol was effective in one of the patients, but in the other patient line therapy with pimecrolimus, triamcinolone, and retinoids was needed.Vaginal lichen sclerosus may be underdiagnosed and genital prolapse may favour the development of vaginal lesions.

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2018 Facts, views & vision in ObGyn

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