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Vulvar Cancer

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1. Outcomes of the use of different vulvar flaps for reconstruction during surgery for vulvar cancer. (PubMed)

Outcomes of the use of different vulvar flaps for reconstruction during surgery for vulvar cancer. Vulvar carcinoma is a rare cancer, accounting for 3-5% of all gynecological cancers. Surgery is the standard treatment for patients with early stage vulvar cancer and vulvar reconstruction can be performed for these patients. The present study aimed to compare three different flap and to analyze the outcomes of vulvar surgery.We performed a single-center retrospective study between October 2001 (...) and December 2015. We compare patients who underwent radical surgery for vulvar cancer combined with three different vulvar flap reconstructions (GTF, gluteal thigh flap; RF, rhomboid flap; VYF, V-Y flap). We collected data on the operating time, length of hospital stay, reoperation rate, and postoperative complications.We reviewed 179 patients who underwent radical vulvar surgery and 61 (34%) of these underwent additional reconstruction. There were no significant differences in clinical characteristics

2019 European Journal of Surgical Oncology

2. Screening for Anal Cancer in Women With High-grade Vulvar Dysplasia or Vulvar Cancer.

Screening for Anal Cancer in Women With High-grade Vulvar Dysplasia or Vulvar Cancer. Screening for Anal Cancer in Women With High-grade Vulvar Dysplasia or Vulvar Cancer. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Screening for Anal Cancer in Women With High-grade Vulvar Dysplasia or Vulvar Cancer. (Vulvar-AIN) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03061435 Recruitment Status : Not yet recruiting First Posted

2017 Clinical Trials

3. Vulvar field resection based on ontogenetic cancer field theory for surgical treatment of vulvar carcinoma: a single-centre, single-group, prospective trial. (PubMed)

Vulvar field resection based on ontogenetic cancer field theory for surgical treatment of vulvar carcinoma: a single-centre, single-group, prospective trial. The incidence of vulvar cancer is increasing, but surgical treatment-the current standard of care-often leads to unsatisfactory outcomes, especially in patients with node-positive disease. Preliminary results at our centre showed that locoregional spread of vulvar carcinoma occurs within tissue domains defined by stepwise embryonic (...) and fetal development (ontogenetic cancer fields and associated lymph node regions). We propose that clinical translation of these insights into practice could improve outcomes of surgical treatment of vulvar cancer.We did a single-centre prospective trial at the University of Leipzig's Cancer Center. Eligible patients were aged 18 years or older, had ontogenetic stage 1-3b histologically proven primary carcinoma of the vulva, and had not undergone previous surgical or radiotherapy treatment for vulvar

2018 Lancet Oncology

4. Genital Tract Cancers in Females: Human Papillomavirus Related Cancers (Cervical, Vaginal & Vulvar)

Genital Tract Cancers in Females: Human Papillomavirus Related Cancers (Cervical, Vaginal & Vulvar) BC Guidelines - Province of British Columbia theme_3_collection theme_3_frontend theme_3_collection theme_3_frontend Birth, Adoption, Death, Marriage & Divorce theme_1_collection theme_1_frontend theme_1_collection theme_1_frontend British Columbians & Our Governments theme_data_collection data_frontend theme_data_collection data_frontend Data theme_5_collection theme_5_frontend

2014 Clinical Practice Guidelines and Protocols in British Columbia

5. Ospemifene (Senshio) - vulvar and vaginal atrophy (VVA)

Ospemifene (Senshio) - vulvar and vaginal atrophy (VVA) 1 Published 9 September 2019 1 SMC2170 ospemifene 60mg film-coated tablets (Senshio®) Shionogi Ltd 9 August 2019 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHSScotland. The advice is summarised as follows: ADVICE: following a full submission ospemifene (Senshio ® ) accepted for use within NHSScotland (...) . Indication under review: Treatment of moderate to severe symptomatic vulvar and vaginal atrophy (VVA) in post-menopausal women who are not candidates for local vaginal oestrogen therapy. Ospemifene was associated with significant improvements in physiological parameters (including vaginal maturation index and vaginal pH), and generally associated with improved patient reported symptom scores for vaginal dryness and dyspareunia compared with placebo in patients with VVA. Chairman Scottish Medicines

2019 Scottish Medicines Consortium

6. Vulvar Cancer Treatment (PDQ®): Patient Version

Vulvar Cancer Treatment (PDQ®): Patient Version Vulvar Cancer Treatment (PDQ®) - PDQ Cancer Information Summaries - NCBI Bookshelf Warning: The NCBI web site requires JavaScript to function. Search database Search term Search NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health. PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-. PDQ Cancer Information Summaries [Internet]. Bethesda (MD): ; 2002-. Search term (...) Vulvar Cancer Treatment (PDQ®) Patient Version PDQ Adult Treatment Editorial Board . Published online: May 14, 2018. Created: September 23, 2005 . This PDQ cancer information summary has current information about the treatment of vulvar cancer. It is meant to inform and help patients, families, and caregivers. It does not give formal guidelines or recommendations for making decisions about health care. Editorial Boards write the PDQ cancer information summaries and keep them up to date. These Boards

2018 PDQ - NCI's Comprehensive Cancer Database

7. Lymph node ratio in inguinal lymphadenectomy for squamous cell vulvar cancer: Results from the AGO-CaRE-1 study. (PubMed)

Lymph node ratio in inguinal lymphadenectomy for squamous cell vulvar cancer: Results from the AGO-CaRE-1 study. Lymph node ratio (LNR) can predict treatment outcome and prognosis in patients with solid tumors. Aim of the present analysis was to confirm the concept of using LNR for assessing outcome in patients with vulvar cancer after surgery with inguinal lymphadenectomy in a large multicenter project.The AGO-CaRE-1 study multicenter database was used for analysis. LNR was defined as ratio (...) of affected LN when comparing the two different multivariable models.In women with vulvar cancer LNR appears to be a consistent, independent prognostic parameter for both PFS and OS and allows patient stratification into three distinct risk groups. In survival analyses, LNR outperformed nodal status and number of positive nodes.Copyright © 2019 Elsevier Inc. All rights reserved.

2019 Gynecologic Oncology

8. Pathological process has a crucial role in sentinel node biopsy for vulvar cancer. (PubMed)

Pathological process has a crucial role in sentinel node biopsy for vulvar cancer. To report the interim findings of an audit of the outcomes of sentinel node (SN) biopsy performed as a replacement for groin node dissection in women with early stage vulvar cancer in routine clinical practice in Australia and New Zealand.A prospective multi-center study in 8 participating centers. Eligible patients had squamous cell carcinomas clinically restricted to the vulva <4 cm in diameter. SN procedures (...) and pathological assessment were to be performed in accordance with the methods published by the GROINSS-V collaboration [1].130 women with apparent early stage vulvar cancer were enrolled. Seventeen women subsequently did not meet the eligibility criteria and were excluded. SNs were identified in 111/113 of the remaining women. Twenty-two women had positive nodes. Sixteen of these women had at least 12 months follow up and 7 (44%) had recurrent disease. Eighty-nine women had only negative nodes. Seventy-four

2019 Gynecologic Oncology

9. Ultrasound and 3D SPECT/CT Fusion to identify sentinel lymph nodes in vulvar cancer: a feasibility study. (PubMed)

Ultrasound and 3D SPECT/CT Fusion to identify sentinel lymph nodes in vulvar cancer: a feasibility study. To evaluate the feasibility of Fusion of SPECT/CT and ultrasound in detecting sentinel lymph nodes in patients with vulvar cancer.This is a prospective pilot monocentric study. Patients with vulvar cancer candidate for sentinel lymph node biopsy were enrolled between December 2018 and February 2019. Fusion virtual navigation of SPECT/CT and ultrasound was performed to investigate the tumor (...) for performing Fusion decreased from the first to the last examination.The present study demonstrated that the Fusion virtual navigation using SPECT/CT and ultrasound is feasible and it is able to detect sentinel lymph nodes in patients with vulvar carcinoma. Fusion using ultrasound scan in detecting sentinel lymph node opens up to multiple diagnostic and therapeutic opportunities in gynecological oncology. This article is protected by copyright. All rights reserved.This article is protected by copyright

2019 Ultrasound in Obstetrics and Gynecology

10. Uptake of sentinel lymph node procedures in women with vulvar cancer over time in a population based study. (PubMed)

Uptake of sentinel lymph node procedures in women with vulvar cancer over time in a population based study. To evaluate trends in uptake of sentinel lymph node (SLN) procedures over time and associated factors in women with vulvar cancer.A retrospective population-based cohort study identified women with invasive squamous cell carcinoma (SCC) of the vulva using health administrative data for the province of Ontario, Canada, between 2008 and 2016. Patients who underwent SLN procedures were (...) ) and institution (Site 5, OR 19.6 [CI 3.6-108.3] and Site 6, [OR 6, CI 1.1-33.4]).The proportion of SLN procedures in women with vulvar cancer has increased over time, but uptake is not uniform across institutions. Barriers to uptake should be explored.Copyright © 2019. Published by Elsevier Inc.

2019 Gynecologic Oncology

11. Ultrasound morphometric and cytologic preoperative assessment of inguinal lymph node status in women with vulvar cancer: the MorphoNode study. (PubMed)

Ultrasound morphometric and cytologic preoperative assessment of inguinal lymph node status in women with vulvar cancer: the MorphoNode study. To assess the accuracy of the ultrasound examination in the prediction of lymph node status (LN) in vulvar cancer patients.This is a single institution retrospective observational study, conducted between December 2010 to January 2016. All women with a histological diagnosis of vulvar cancer triaged to inguinal surgery within 30 days from an ultrasound (...) % and specificity 91.5%), the combination of Short axis and Cortex/Medulla ratio (sensitivity 88.9% and specificity 82.4%), and the FOA analysis (sensitivity 85.9% and specificity of 84.2%).Our results demonstrate that preoperative ultrasound with or without the combination of cytology have a high accuracy in assessing inguinal LNs in patients with vulvar cancer. In particular, the combination of two ultrasound parameters (Short axis and Cortex/Medulla ratio) provided the highest accuracy in discriminating

2019 Ultrasound in Obstetrics and Gynecology

12. Predictive factors for lymph node metastases in vulvar cancer. An analysis of the AGO-CaRE-1 multicenter study. (PubMed)

Predictive factors for lymph node metastases in vulvar cancer. An analysis of the AGO-CaRE-1 multicenter study. Lymph node (LN) metastasis is the most important prognostic factor in primary vulvar cancer. Assessing risk factors for the incidence and extent of LN metastases may help to select the optimal treatment strategy for each individual patient.In a subgroup analysis of the large multicenter AGO-CaRE-1 study we included all patients treated with radical groin dissection. Univariate

2019 Gynecologic Oncology

13. Endoscopic near infrared and indocyanine green to verify the viability of the subcutaneous flap for vulvar cancer. (PubMed)

Endoscopic near infrared and indocyanine green to verify the viability of the subcutaneous flap for vulvar cancer. Vulvar cancer often requires radical vulvectomy with subsequent vulvar flap. Approximately in 20-60% of cases, there are post-operative complications ranging from infection to flap necrosis that often require reoperation. Several methods have been described to verify the vitality of the flap, but these are often expensive and require specific machinery that is not generally present (...) in a gynecological clinic. In this case report, we present a viability verification of VY fasciocutaneous advancement flap for vulvar reconstruction by Endoscopic Near-Infrared and Indocyanine Green.The patient was a 67-year-old woman with FIGO IB ≤ 4 cm squamous cell vulvar cancer with absence of inguinal lymphadenopathy. The lesion appeared about 35 mm from the lateral margin of the large left lip and extended to the left inguinocrural fold. The patient underwent left inguinal lymphadenectomy and left radical

2019 Gynecologic Oncology

14. Predicting the course of disease in recurrent vulvar cancer - A subset analysis of the AGO-CaRE-1 study. (PubMed)

Predicting the course of disease in recurrent vulvar cancer - A subset analysis of the AGO-CaRE-1 study. In vulvar cancer (VSCC), the course of disease with regard to localization of recurrence and relation of different recurrence sites is poorly described.The AGO CaRE-1 study is a retrospective survey of treatment patterns and prognostic factors in vulvar cancer. Patients (pts) with primary VSCC, FIGO stage ≥1B treated in Germany from 1998 to 2008 were included in a centralized database (n  (...) ratios (HRs) (95% confidence interval) to die for pts with compared to without recurrence at the same time: vulvar only: 5.9 (4.3-8.2); groins only: 6.0 (3.0-10.2); vulvar and groins: 14.1 (7.6-26.4); pelvic/distant: 21.2 (15.3-29.4). Fifty-eight (30.1%) pts with local recurrence developed second recurrence. 2-year mortality after any recurrence was 56.3%. After vulvar recurrence pts had a 2-year and 5-year overall survival rate of 82.2% and 66.9%.Prognosis after recurrence is highly depending

2019 Gynecologic Oncology

15. Risk of cervical and vaginal dysplasia after surgery for vulvar intraepithelial neoplasia or cancer: A 6 year follow-up study. (PubMed)

Risk of cervical and vaginal dysplasia after surgery for vulvar intraepithelial neoplasia or cancer: A 6 year follow-up study. To estimate the frequency of abnormal surveillance cytology leading to high-grade dysplasia after surgical management for high-grade vulvar intraepithelial neoplasia (VIN) and vulvar cancer and to determine whether prior hysterectomy reduces this risk.Women who underwent surgery for high-grade VIN or vulvar cancer between 2006 and 2014 were identified retrospectively (...) %) were high-grade, including 2 (3%) cases of invasive cancer. The rates of high-grade vaginal intraepithelial neoplasia (VAIN), cervical intraepithelial neoplasia (CIN), or cancer were not significantly different despite prior hysterectomy (9% VAIN 2+, 7% CIN 2+). Multivariate analysis showed that correlates of high-grade cytology following treatment for VIN or vulvar cancer included non-white race [odds radio (OR) 3.6, 95% confidence interval (CI) 1.7-7.8], prior abnormal cytology (OR 3.5, 95% CI

2019 Gynecologic Oncology

16. Long term outcomes in patients with sentinel lymph nodes (SLNs) identified by injecting remaining scar after previously excised vulvar cancer. (PubMed)

Long term outcomes in patients with sentinel lymph nodes (SLNs) identified by injecting remaining scar after previously excised vulvar cancer. Lymph node metastasis is the most important prognostic factor in patients with vulvar squamous cell carcinoma (SCC). Previous excision of the vulvar tumor may disrupt lymphatic channels and alter the accuracy of the sentinel lymph node (SLN) biopsy. The purpose of this study was to measure outcomes after SLN biopsy in patients with and without previous (...) excision of the vulvar tumor.Retrospective study of patients at a single institution with primary vulvar cancer, clinically negative nodes, and vulvar tumors < 4 cm treated with surgical excision who had SLN biopsy (2008-2015).There were 106 cases of concomitant wide local excision (WLE) and SLN biopsy and 24 additional cases of patients who had previous vulvar surgery and no visible tumor; these patients underwent scar re-excision and SLN biopsy. Median follow-up was 31 months. Patients who had

2019 Gynecologic Oncology

17. Surgical treatment of vulvar cancer: Impact of tumor-free margin distance on recurrence and survival. A multicentre cohort analysis from the francogyn study group. (PubMed)

Surgical treatment of vulvar cancer: Impact of tumor-free margin distance on recurrence and survival. A multicentre cohort analysis from the francogyn study group. In vulvar cancer, it is admitted that tumor-free margin distance is one of the most important element for locoregional control. It is currently recommended to surgically remove the tumor with at least an 8 mm tumor-free margin. The aim of this study was to evaluate the impact of tumor-free margin distance on recurrence and survival (...) in vulvar cancer.From 2005 to 2016, 112 patients surgically treated for a vulvar squamous cell cancer were included in a retrospective multicenter study. Overall, disease-free and metastasis-free survivals were analyzed according to tumor-free margin distance.Patients were divided into three groups: group 1 (margin <3 mm, n = 47); group 2 (margin ≥3 mm to < 8 mm, n = 48) and group 3 (margin ≥8 mm, n = 17). During the study, 26,8% patients developed recurrence (n = 30) after a median of 8 months (1-69

2019 European Journal of Surgical Oncology

18. Multivariate analysis of prognostic factors in primary squamous cell vulvar cancer: The role of perineural invasion in recurrence and survival. (PubMed)

Multivariate analysis of prognostic factors in primary squamous cell vulvar cancer: The role of perineural invasion in recurrence and survival. to assess the prognostic role in recurrence and survival of perineural invasion (PNI) in vulvar squamous cell cancer (VSCC).Patients underwent primary surgery for VSCC from January 2009 to December 2016 served as the study cohort. We collected demographic, clinical, pathological characteristics and follow-up data, and we compared them among PNI-negative (...) . OS was significantly reduced in case of PNI (HR 4.93; CI95% 1.33-18.35; p = 0.01) and extracapsular lymph nodal disease (HR 10.63; CI95% 1.65-68.57; p = 0.01).PNI is an independent prognostic factor for aggressive behavior and unfavorable course in VSCC and should be considered in adjuvant treatment planning.Copyright © 2019 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

2019 European Journal of Surgical Oncology

19. Diagnosis and management of vulvar cancer: A review. (PubMed)

Diagnosis and management of vulvar cancer: A review. Vulvar malignancies represent a serious gynecologic health concern, especially given the increasing incidence over the past several decades. Squamous cell carcinoma and melanoma are common subtypes, although other neoplasms, such as basal cell carcinoma and Paget disease of the vulva, might be seen. Many vulvar cancers are initially misdiagnosed as inflammatory conditions, delaying diagnosis and worsening prognosis. It is essential (...) that dermatologists are familiar with characteristic findings for each malignancy to ensure appropriate diagnosis and management. Herein, we review the unique epidemiologic and clinical characteristics of each major vulvar malignancy, as well as discuss their respective prognoses and current management recommendations.Copyright © 2019 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

2019 Journal of American Academy of Dermatology

20. Incidences and risk factors of metachronous vulvar, vaginal, and anal cancers after cervical cancer diagnosis. (PubMed)

Incidences and risk factors of metachronous vulvar, vaginal, and anal cancers after cervical cancer diagnosis. To examine incidences and risk factors for metachronous vulvar, vaginal, and anal malignancies after a cervical cancer diagnosis.This is a retrospective study examining data from the Surveillance, Epidemiology, and End Result Program between 1973 and 2013. Cumulative incidences of vulvar, vaginal, and anal cancers after the diagnosis of cervical cancer were assessed (n = 79,050 (...) ). Multivariable analysis was performed to determine independent risk factors for these metachronous cancers.Vaginal cancer (20-year cumulative incidence, 0.57%) was the most common type of metachronous malignancy, followed by vulvar cancer (0.33%), and anal cancer (0.16%, P < 0.001). Median time to diagnosis was 5.4 years for vaginal cancer, 6.5 years for vulvar cancer, and 13.5 years for anal cancer. On multivariable analysis, metachronous vulvar cancer was associated with older age (hazard ratio [HR] per

2018 Gynecologic Oncology

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