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Vomiting History

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1. A History of Drug Discovery for Treatment of Nausea and Vomiting and the Implications for Future Research Full Text available with Trip Pro

A History of Drug Discovery for Treatment of Nausea and Vomiting and the Implications for Future Research The origins of the major classes of current anti-emetics are examined. Serendipity is a recurrent theme in discovery of their anti-emetic properties and repurposing from one indication to another is a continuing trend. Notably, the discoveries have occurred against a background of company mergers and changing anti-emetic requirements. Major drug classes include: (i) Muscarinic receptor (...) ), a major breakthrough in treatment of chemotherapy-induced emesis; (v) Neurokinin1receptor antagonists-antagonists of the actions of substance P were developed as analgesics but pre-clinical studies identified broad-spectrum anti-emetic effects; clinical studies showed particular efficacy in the delayed phase of chemotherapy-induced emesis. Finally, the repurposing of different drugs for treatment of nausea and vomiting is examined, particularly during palliative care, and also the challenges

2018 Frontiers in pharmacology

2. Assessment of nausea and vomiting in children

drugs. Diagnosis A complete history and meticulous physical examination is essential and provides the clues for appropriate diagnosis and management. Diagnostic testing should be directed by the clinical picture. American Gastroenterological Association. American Gastroenterological Association medical position statement: nausea and vomiting. Gastroenterology. 2001 Jan;120(1):261-3. http://www.ncbi.nlm.nih.gov/pubmed/11208735?tool=bestpractice.com Urgent considerations, particularly neurological (...) Assessment of nausea and vomiting in children Assessment of nausea and vomiting in children - Differential diagnosis of symptoms | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Assessment of nausea and vomiting in children Last reviewed: February 2019 Last updated: October 2018 Summary Nausea and vomiting are very common symptoms in the paediatric population. Whether presenting in the emergency department or in an outpatient clinic, they are a frequent

2018 BMJ Best Practice

3. Assessment of nausea and vomiting in children

drugs. Diagnosis A complete history and meticulous physical examination is essential and provides the clues for appropriate diagnosis and management. Diagnostic testing should be directed by the clinical picture. American Gastroenterological Association. American Gastroenterological Association medical position statement: nausea and vomiting. Gastroenterology. 2001 Jan;120(1):261-3. http://www.ncbi.nlm.nih.gov/pubmed/11208735?tool=bestpractice.com Urgent considerations, particularly neurological (...) Assessment of nausea and vomiting in children Assessment of nausea and vomiting in children - Differential diagnosis of symptoms | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Assessment of nausea and vomiting in children Last reviewed: February 2019 Last updated: October 2018 Summary Nausea and vomiting are very common symptoms in the paediatric population. Whether presenting in the emergency department or in an outpatient clinic, they are a frequent

2018 BMJ Best Practice

4. Nausea and vomiting in pregnancy

of NVP and is characterised by persistent vomiting, volume depletion, ketosis, electrolyte disturbances, and weight loss. History and exam presence of risk factors first trimester of pregnancy weight loss of >5% absence of thyroid enlargement/nodules absence of central nervous system (CNS) signs dry mucous membranes postural dizziness tachycardia hypotension ketotic breath family history of hyperemesis gravidarum previous history of NVP multiple gestation or increased placental mass gestational (...) Nausea and vomiting in pregnancy Nausea and vomiting in pregnancy - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Nausea and vomiting in pregnancy Last reviewed: February 2019 Last updated: March 2018 Summary Affects approximately 75% of pregnant women. Typically begins between the fourth and seventh week after the last menstrual period and resolves in the second trimester. Aetiology remains unclear. There is some

2018 BMJ Best Practice

5. 2016 MASCC and ESMO guideline update for the prevention of chemotherapy- and radiotherapy-induced nausea and vomiting and of nausea and vomiting in advanced cancer patients Full Text available with Trip Pro

2016 MASCC and ESMO guideline update for the prevention of chemotherapy- and radiotherapy-induced nausea and vomiting and of nausea and vomiting in advanced cancer patients We use cookies to enhance your experience on our website. By continuing to use our website, you are agreeing to our use of cookies. You can change your cookie settings at any time. 2016 MASCC and ESMO guideline update for the prevention of chemotherapy- and radiotherapy-induced nausea and vomiting and of nausea and vomiting (...) in advanced cancer patients | Annals of Oncology | Oxford Academic Search Account Menu Menu Navbar Search Filter Mobile Microsite Search Term Close search filter search input Article Navigation Close mobile search navigation Article navigation September 2016 Article Contents Article Navigation 2016 MASCC and ESMO guideline update for the prevention of chemotherapy- and radiotherapy-induced nausea and vomiting and of nausea and vomiting in advanced cancer patients F. Roila 1Medical Oncology, Santa Maria

2016 International Society for Oral Oncology

6. Vomiting History

Vomiting History Vomiting History Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Vomiting History Vomiting History Aka: Vomiting (...) ) Rosen's Emergency Med, p. 178 Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Vomiting History." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics in Symptoms About FPnotebook.com is a rapid access, point-of-care medical reference for primary care and emergency clinicians. Started in 1995, this collection now contains 6656 interlinked topic

2018 FP Notebook

7. Prevention of chemotherapy induced nausea and vomiting in adults: netupitant/palonosetron

Prevention of chemotherapy induced nausea and vomiting in adults: netupitant/palonosetron Pre Prev vention of chemother ention of chemotherap apy induced nausea and y induced nausea and v vomiting in adults: netupitant/palonosetron omiting in adults: netupitant/palonosetron Evidence summary Published: 1 March 2016 nice.org.uk/guidance/esnm69 pathways K Ke ey points from the e y points from the evidence vidence The content of this evidence summary was up-to-date in March 2016. See summaries (...) of product characteristics (SPCs), British national formulary (BNF) or the MHRA or NICE websites for up-to-date information. Summary Netupitant/palonosetron shows statistically significant benefits compared with palonosetron alone (both in combination with dexamethasone) in people receiving emetogenic chemotherapy, mainly in the prevention of delayed nausea and vomiting. There are limited data comparing netupitant/ palonosetron with other neurokinin-1 receptor antagonists (such as, aprepitant) and 5-HT 3

2016 National Institute for Health and Clinical Excellence - Advice

8. Does intramuscular ondansetron have an effect on intramuscular ketamine-associated vomiting in children? A prospective, randomized, double blind, controlled study

Does intramuscular ondansetron have an effect on intramuscular ketamine-associated vomiting in children? A prospective, randomized, double blind, controlled study Does Intramuscular Ondansetron Have an Effect on Intramuscular Ketamine-Associated Vomiting in Children? A Prospective, Randomized, Double Blind, Controlled Study - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go (...) to . Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health U.S. National Library of Medicine National Center for Biotechnology Information Show account info Close Account Logged in as: username (My NCBI) (My Bibliography) Search: Search Save Email … Send To Save citation to file Format: Create file Cancel Email citation To: Subject: Body: Format: Send email Cancel Add to Collections Create a new collection Add to an existing collection Name

2020 EvidenceUpdates

9. Guidelines on the Prevention of Postoperative Vomiting in Children

Courtman Neil Morton Scott Jacobson Liam Brennan Per-Arne Lönnqvist Jackie Pope 3 Contents Page No. Key to evidence statements and grades of recommendation 4 Introduction 5 Remit of the guideline Glossary 7 1. Identifying children at high risk of postoperative vomiting (POV) 8 A. Patient factors Age, history of POV, motion sickness, gender, preoperative anxiety, smoking 8 B. Surgical Factors Duration of surgery, type of surgery 10 C. Anaesthetic Factors Nitrous oxide, volatile agents, peri-operative (...) antiemetic medication. 1. Identifying Children at High Risk of Postoperative Vomiting Guidelines on the Prevention of Postoperative Vomiting in Children History of POV This has proved to be an important risk factor in the majority of studies in the adult and paediatric POV literature and is included in all of the risk scoring systems to aid prediction of POV that have been published to date 12 . A specific paediatric cohort study identified “previous POV” and “POV in a parent or sibling” as important

2017 Association of Paediatric Anaesthetists of Great Britain and Ireland

10. Guideline for the prevention of acute chemotherapy-induced nausea and vomiting in pediatric cancer patients: a focused update.

Guideline for the prevention of acute chemotherapy-induced nausea and vomiting in pediatric cancer patients: a focused update. Guideline for the prevention of acute chemotherapy-induced nausea and vomiting in pediatric cancer patients: a focused update. | National Guideline Clearinghouse success fail JUN 09 2017 2018 2019 14 Apr 2018 - 12 Jul 2018 COLLECTED BY Organization: Formed in 2009, the Archive Team (not to be confused with the archive.org Archive-It Team) is a rogue archivist collective (...) dedicated to saving copies of rapidly dying or deleted websites for the sake of history and digital heritage. The group is 100% composed of volunteers and interested parties, and has expanded into a large amount of related projects for saving online and digital history. History is littered with hundreds of conflicts over the future of a community, group, location or business that were "resolved" when one of the parties stepped ahead and destroyed what was there. With the original point of contention

2017 National Guideline Clearinghouse (partial archive)

11. Vomiting is the most common adverse effect among children and young people sedated for emergency procedures

Vomiting is the most common adverse effect among children and young people sedated for emergency procedures Vomiting is the most common adverse effect among children and young people sedated for emergency procedures Discover Portal Discover Portal Vomiting is the most common adverse effect among children and young people sedated for emergency procedures Published on 27 September 2016 doi: Vomiting is the most common adverse event when sedating a child or young person undergoing a procedure (...) and their definitions. The studies were combined using a statistical model that takes account of the differences between study results. However, there is still some need for caution about the estimated likelihood of adverse events, particularly for drugs used less frequently, such as etomidate, midazolam or propofol. What did it find? Vomiting was the most common adverse event, occurring in 498 out of 7,865 sedations where it was reported as an outcome – around 55.5 episodes for every 1,000 sedations. Rates

2019 NIHR Dissemination Centre

12. CRACKCast E029 – Nausea and Vomiting

) Vomiting “Forceful expulsion of gastric contents through the mouth” The abdominal and thoracic muscles work together to simultaneously relax and contract certain muscles to expel the contents out. The glottis is usually closed to prevent aspiration Pivotal findings History Acute vomiting – more likely serious etiologies Chronic – more likely partial obstructions, motility disorders, neurologic conditions Timing Delayed – 1 – 12 hours post eating: Gastric outlet obstruction or gastroparesis (diabetes (...) ) Content of vomit: Bile – means duodenum and stomach are connected (no outlet obstruction) Undigested food – achalasia, esophageal stricture, Zenker’s diverticulum, Feculent material – distal bowel obstruction Associated symptoms and signs: Chronic nausea/vomiting with headaches – CNS pathology Vomiting without nausea – CNS pathology Social/Medical history: ETOH use GI disease / surgeries Medication list Physical exam Red flags: Adult vs. Pediatric exam varies – need to do a full physical exam Bulging

2017 CandiEM

13. Essential Oils to Reduce Postoperative Nausea and Vomiting. (Abstract)

Essential Oils to Reduce Postoperative Nausea and Vomiting. The purpose of this study was to determine if using essential oil products for adult patients reduced the need for antiemetics for postoperative nausea and vomiting (PONV).A prospective and retrospective cross-sectional design using a convenience sample.Double blinded to the type of essential oil, subjects randomly selected a nasal inhaler containing peppermint, ginger, or a combination of both. A prophylactic dose was given (...) preoperatively, and during the postoperative period nausea was assessed using verbal descriptive scale.Overall 322 same day surgical patients were analyzed (control group [n = 179] and intervention group [n = 143]). The intervention group had a greater history of PONV but received fewer doses of antiemetics postoperatively compared with the control group. There was no significant difference in the effectiveness of the three types of inhalers.Aromatherapy demonstrated a statistically significant (P < .05

2019 Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses Controlled trial quality: uncertain

14. Cannabinoids for nausea and vomiting in adults with cancer receiving chemotherapy. Full Text available with Trip Pro

Cannabinoids for nausea and vomiting in adults with cancer receiving chemotherapy. Cannabis has a long history of medicinal use. Cannabis-based medications (cannabinoids) are based on its active element, delta-9-tetrahydrocannabinol (THC), and have been approved for medical purposes. Cannabinoids may be a useful therapeutic option for people with chemotherapy-induced nausea and vomiting that respond poorly to commonly used anti-emetic agents (anti-sickness drugs). However, unpleasant adverse (...) effects may limit their widespread use.To evaluate the effectiveness and tolerability of cannabis-based medications for chemotherapy-induced nausea and vomiting in adults with cancer.We identified studies by searching the following electronic databases: Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, PsycINFO and LILACS from inception to January 2015. We also searched reference lists of reviews and included studies. We did not restrict the search by language

2015 Cochrane

15. MASCC and ESMO Consensus Guidelines for the Prevention of Chemotherapy and Radiotherapy-Induced Nausea and Vomiting

MASCC and ESMO Consensus Guidelines for the Prevention of Chemotherapy and Radiotherapy-Induced Nausea and Vomiting 2016MASCCandESMOguidelineupdateforthe preventionofchemotherapy-andradiotherapy-induced nauseaandvomitingandofnauseaandvomitingin advancedcancerpatients F.Roila 1 ,A.Molassiotis 2 ,J.Herrstedt 3 ,M.Aapro 4 ,R.J.Gralla 5 ,E.Bruera 6 ,R.A.Clark-Snow 7 , L.L.Dupuis 8 ,L.H.Einhorn 9 ,P.Feyer 10 ,P.J.Hesketh 11 ,K.Jordan 12 ,I.Olver 13 ,B.L.Rapoport 14 , J.Roscoe 15 ,C.H.Ruhlmann 3 (...) ,TheNetherlands introduction Despite the considerable progress achieved in the last 30 years, vomiting and, especially, nausea, continue to be twoof the most distressing side-effects of cancer chemotherapy. In the late 1990s, several professional organisations published recommen- dations on the optimal antiemetic prophylaxis in patients sub- mitted to chemotherapy and/or radiotherapy. The European Society of Medical Oncology (ESMO) and the Multinational Association of Supportive Care in Cancer (MASCC

2017 European Society for Medical Oncology

16. Palonosetron Hospira - Cancer, Nausea and Vomiting

Palonosetron Hospira - Cancer, Nausea and Vomiting 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Union Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5520 Send a question via our website www.ema.europa.eu/contact 25 February 2016 EMA/215640/2016 Committee for Medicinal Products for Human Use (CHMP) Assessment report Palonosetron Hospira International non-proprietary name: palonosetron Procedure No. EMEA/H/C/004069/0000 Note Assessment (...) Authorisation is or has been granted in the Union on the basis of a complete dossier in accordance with Article 8(3) of Directive 2001/83/EC. The applicant applied for the following indication: Palonosetron Hospira is indicated in adults for: - the prevention of acute nausea and vomiting associated with highly emetogenic cancer chemotherapy, - the prevention of nausea and vomiting associated with moderately emetogenic cancer chemotherapy. The legal basis for this application refers to: Generic application

2016 European Medicines Agency - EPARs

17. Acupressure in Management of Postoperative Nausea and Vomiting in High-Risk Ambulatory Surgical Patients. (Abstract)

of PeriAnesthesia Nurses PONV/postdischarge nausea and vomiting guidelines: female, PONV history or motion sickness, nonsmoker, and volatile gas general anesthetic. One hundred ten patients were randomly assigned to an intervention (N = 57) acupressure bead patch or control (N = 53) sham acupressure patch group. Patients rated PONV on scale (0 to 10).Acupressure use at P6 preoperatively was statistically significant in reducing PONV in all three postoperative phases. One hundred ten patients were enrolled; 93 (...) Acupressure in Management of Postoperative Nausea and Vomiting in High-Risk Ambulatory Surgical Patients. The purpose of this randomized blinded placebo-controlled research study was to investigate the effect of acupressure over 24 hours postoperatively for ambulatory surgical patients who are identified as high risk for PONV.A randomized blinded placebo-controlled study design was implemented.Study enrollment criteria included four of five risk factors as defined in 2006 by American Society

2018 Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses Controlled trial quality: uncertain

18. The Management of Nausea and Vomiting of Pregnancy and Hyperemesis Gravidarum

assessment and baseline investigations should be done before deciding on treatment? Clinicians should be aware of the features in history, examination and investigation that allow NVP and HG to be assessed and diagnosed and for their severity to be monitored. Table 1. Features in the history, examination and investigations to monitor severity and other causes History Previous history of NVP/HG Quantify severity using PUQE score: nausea, vomiting, hypersalivation, spitting, loss of weight, inability (...) The Management of Nausea and Vomiting of Pregnancy and Hyperemesis Gravidarum The Management of Nausea and Vomiting of Pregnancy and Hyperemesis Gravidarum Green-top Guideline No. 69 June 2016The Management of Nausea and Vomiting of Pregnancy and Hyperemesis Gravidarum This is the first edition of this guideline. Executive summary of recommendations Diagnosis of nausea and vomiting of pregnancy (NVP) and hyperemesis gravidarum (HG) How is NVP diagnosed? NVP should only be diagnosed when onset

2016 Royal College of Obstetricians and Gynaecologists

19. Nausea and Vomiting

endoscopic intervention if it is appropriate. Regurgitation will never be relieved by anti-emetics but associated persistent nausea may respond to the appropriate medication. Assessment History ‒ A separate history for both nausea and vomiting: triggers, volume, pattern exacerbating and relieving factors, including individual and combinations of drugs tried and routes used bowel habit medication. Examination: general review for signs of dehydration, sepsis and drug toxicity central nervous system abdomen (...) Nausea and Vomiting Scottish Palliative Care Guidelines - Nausea and Vomiting Scottish Palliative Care Guidelines search / / / Nausea and Vomiting Nausea and Vomiting Introduction The management of nausea and vomiting for individuals receiving palliative care can be complex. Many of the published guidelines and recommendations are based on a theoretical understanding of the mechanisms of nausea and vomiting and there is little robust clinical evidence to support practice. Nausea and vomiting

2015 Scottish Palliative Care Guidelines

20. Treatment-Related Nausea and Vomiting (PDQ®): Health Professional Version

Treatment-Related Nausea and Vomiting (PDQ®): Health Professional Version Treatment-Related Nausea and Vomiting (PDQ®) - PDQ Cancer Information Summaries - NCBI Bookshelf Warning: The NCBI web site requires JavaScript to function. Search database Search term Search NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health. PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-. PDQ Cancer Information Summaries (...) [Internet]. Bethesda (MD): ; 2002-. Search term Treatment-Related Nausea and Vomiting (PDQ®) Health Professional Version PDQ Supportive and Palliative Care Editorial Board . Published online: October 30, 2019. This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the pathophysiology and treatment of nausea and vomiting (emesis) (N&V). It is intended as a resource to inform and assist clinicians who care for cancer patients

2018 PDQ - NCI's Comprehensive Cancer Database

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