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Vitiligo

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161. Habits and Risk Perception Associated with Sun Exposure in Vitiligo Patients according to their participation in a patients' organization. (PubMed)

Habits and Risk Perception Associated with Sun Exposure in Vitiligo Patients according to their participation in a patients' organization. 30284740 2019 03 20 1468-3083 33 3 2019 Mar Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Habits and risk perception associated with sun exposure in vitiligo patients according to their participation in a patients' organization. e100-e103 10.1111/jdv.15264 Bhatia B B Department of Dermatology, Henry Ford (...) Hospital, Detroit, MI, USA. Kechichian E E Department of Dermatology, CHU Henri Mondor, Créteil, France. Eleftheriadou V V Centre of Evidence Based Dermatology, Kings Meadow Campus, University of Nottingham, Nottingham, UK. Castelneau J-P JP Department of Dermatology, CHU Henri Mondor, Créteil, France. Seité S S La Roche-Posay Laboratoire Dermatologique, Paris, France. Meurant J-M JM Association Française du Vitiligo, Paris, France. Hamzavi I I Department of Dermatology, Henry Ford Hospital, Detroit

2018 Journal of the European Academy of Dermatology and Venereology

162. A comparative study between suction blistering graft, mini punch graft and hair follicle transplant in treatment of patients with stable vitiligo. (PubMed)

A comparative study between suction blistering graft, mini punch graft and hair follicle transplant in treatment of patients with stable vitiligo. Vitiligo is an acquired disfiguring common depigmented skin disease.This study aimed to compare the clinical efficacy and safety of suction blistering graft, mini punch and hair follicle techniques in treatment of patients with stable vitiligo.Thirty patients with stable vitiligo were included. Patients were divided into 3 groups, in group (A) 10 (...) patient underwent suction blistering technique, in group (B) 10 patients underwent mini punch technique and in group (C) 10 patients underwent hair follicle technique. Then all patients in the three techniques were subjected to narrow-band ultraviolet B (NB-UVB) phototherapy for 3 months. All patients were assessed by determining the percentage of repigmentation and Dermatology Life Quality Index (DLQI) before and 3 months after the operation.The percentage of repigmentation of vitiligo in suction

2018 Journal of Dermatological Treatment

163. Association of vitiligo with hospitalization for mental health disorders in US adults. (PubMed)

Association of vitiligo with hospitalization for mental health disorders in US adults. Vitiligo has a complex bidirectional relationship with mental health (MH) disturbances. However, little is known about the relationship between vitiligo and MH emergencies.To examine the associations of vitiligo and MH hospitalizations in the United States.Data from the 2002 to 2012 National Inpatient Sample were analysed, including a ~20% sample of all US hospitalizations (n = 87 053 155 children and adults (...) ). Prevalence of hospitalization for MH disorders, their length of stay (LOS) and cost of care were determined for those with vitiligo compared to those without vitiligo.Hospitalization for MH disorders occurred more commonly in those with vitiligo compared to those without vitiligo (4.17% vs. 2.18%). In multivariable logistic regression models, vitiligo was associated with higher odds of admission for any MH disorder [adjusted odds ratio (95% confidence interval): 1.69 (1.61-1.78)], including 14 of 15 MH

2018 Journal of the European Academy of Dermatology and Venereology

164. Vitiligo surgery: a journey from tissues via cells to the stems! (PubMed)

Vitiligo surgery: a journey from tissues via cells to the stems! Depigmented patches in vitiligo, a common dermatosis, cause a great psychological distress to the patients. Hence, apart from halting the disease process, the strategies to impart normal skin colour to these white patches carry an important role in the management of vitiligo. Surgical procedures are often required for stable vitiligo lesions not responding to medical therapies. It involves "shuffling" of melanocytes from (...) the pigmented skin to the depigmented areas. During the last fifty years, the vitiligo surgery has evolved from tissue transplantation via cellular transplantation to reach a stage where the use of stem cells or immunomodulatory cells is contemplating. We would like to depict this wonderful journey of vitiligo surgery through this viewpoint.© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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2018 Experimental Dermatology

165. Association Between Psoriasis and Vitiligo: A Systematic Review and Meta-Analysis. (PubMed)

Association Between Psoriasis and Vitiligo: A Systematic Review and Meta-Analysis. The relationship between psoriasis and vitiligo has not been previously confirmed, and we therefore aimed to investigate this association.We conducted a search of the MEDLINE and EMBASE electronic databases on 22 January 2018 for case-control, cross-sectional, and cohort studies examining the association between psoriasis and vitiligo. A customized Newcastle-Ottawa Scale was used to assess the risk of bias (...) of the included studies. We performed a random effects meta-analysis to calculate pooled odds ratios (ORs) with 95% confidence intervals (CIs) for case-control and cross-sectional studies.Of 2453 citations identified from the literature search, 10 case-control/cross-sectional studies with a total of 120,866 psoriasis cases and 79,907 vitiligo cases were included in our study. Four of these studies were rated as high risk of bias. We found a significantly increased odds for vitiligo in psoriasis patients

2018 American journal of clinical dermatology

166. Reference method for digital surface measurement of target lesions in vitiligo: a comparative analysis. (PubMed)

Reference method for digital surface measurement of target lesions in vitiligo: a comparative analysis. Objective measurement of target lesions in vitiligo is important for clinical practice and trials, yet no preferred tool has been defined. Reported digital tools have shortcomings related to feasibility aspects and often lack information on validity, reliability and responsiveness. Moreover, studies are not yet based on ultraviolet (UV) photography.To assess the reliability, validity (...) and feasibility of two functions in ImageJ for measurement of target lesions, based on three different types of images including UV pictures.Planimetric measurements were performed on photographs with and without UV, and lesion contours on transparent sheets of 52 vitiligo lesions from 10 patients with vitiligo. The ImageJ functions 'wand' and 'threshold' were used by three and four assessors, respectively. Inter- and intrarater reliability, hypothesis testing for construct validity, and feasibility were

2018 British Journal of Dermatology

167. Comparison of Surgical Methods on Resistant Sites in Stable Vitiligo Patients

Comparison of Surgical Methods on Resistant Sites in Stable Vitiligo Patients Comparison of Surgical Methods on Resistant Sites in Stable Vitiligo Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Comparison of Surgical Methods on Resistant Sites in Stable Vitiligo Patients The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03717025 Recruitment Status : Recruiting First Posted : October 23, 2018 Last Update Posted

2018 Clinical Trials

168. The Effect of UVB Phototherapy With Microneedling and Circled Needing in Vitiligo Patients

The Effect of UVB Phototherapy With Microneedling and Circled Needing in Vitiligo Patients The Effect of UVB Phototherapy With Microneedling and Circled Needing in Vitiligo Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. The Effect of UVB Phototherapy With Microneedling and Circled Needing in Vitiligo Patients The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03718962 Recruitment Status : Recruiting First Posted

2018 Clinical Trials

169. Activation of melanoblasts and melanocytes after treatment with monochromatic excimer light and narrowband-ultraviolet B of skin of vitiligo patients. (PubMed)

Activation of melanoblasts and melanocytes after treatment with monochromatic excimer light and narrowband-ultraviolet B of skin of vitiligo patients. Vitiligo is a hypopigmentation disease characterized by achromatic or hypochromatic macules in several sites of human skin. Although monochromatic excimer light (MEL) and narrowband-ultraviolet B (NB-UVB) have recently been used for efficacious treatment of vitiligo, the repigmentation process and role of melanocytes/melanoblasts are not well (...) known.White macules of 28 vitiligo patients were repeatedly exposed with MEL/NB-UVB. After the exposures, punch biopsies of the center and edge of the lesional skin in addition to normal skin were fixed and processed to dopa and combined dopa-premelanin reactions. Melanocytes positive to the dopa reaction and melanoblasts/melanocytes positive to the combined dopa-premelanin reaction were surveyed.Two repigmentation patterns were observed; one was "marginal" and the other was "perifollicular." Although

2018 International Journal of Dermatology

170. Addition of oral mini pulse dexamethasone to NBUVB phototherapy and topical steroids helps arrest disease activity in patients with vitiligo. (PubMed)

Addition of oral mini pulse dexamethasone to NBUVB phototherapy and topical steroids helps arrest disease activity in patients with vitiligo. 30188576 2019 01 03 1365-2133 180 1 2019 Jan The British journal of dermatology Br. J. Dermatol. Addition of oral minipulse dexamethasone to narrowband ultraviolet B phototherapy and topical steroids helps arrest disease activity in patients with vitiligo. 193-194 10.1111/bjd.17150 Tovar-Garza A A Department of Dermatology, University of Texas

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2018 British Journal of Dermatology

171. Laser Ablation of the Recipient Area With Platelet-Rich Plasma-Enriched Epidermal Suspension Transplant in Vitiligo Surgery: A Pilot Study. (PubMed)

Laser Ablation of the Recipient Area With Platelet-Rich Plasma-Enriched Epidermal Suspension Transplant in Vitiligo Surgery: A Pilot Study. Noncultured epidermal cell suspension transplantation is a very popular surgical modality for treating vitiligo. However, the procedure can be modified to improve results.To study the extent of repigmentation with noncultured trypsinized fragmented epidermal suspension using platelet-rich plasma (PRP) as a suspending agent and pixel erbium yttrium aluminium (...) garnet laser for ablation of recipient area in patients with stable vitiligo.Autologous noncultured tiny epidermal fragments suspended in PRP were grafted on superficially pixel erbium YAG laser-ablated vitiligo lesions in 10 patients. The repigmentation was evaluated over a period of 6 months using a digital image analysis system.Repigmentation was observed as early as 2 weeks after the treatment. Of 20 lesions, 12 (60%) showed excellent response; of which 10 lesions (50%) showed complete

2018 Dermatologic Surgery

172. Motorized 0.8 mm micro-punch grafting for refractory vitiligo: A retrospective study of 230 cases. (PubMed)

Motorized 0.8 mm micro-punch grafting for refractory vitiligo: A retrospective study of 230 cases. Punch grafting for vitiligo is time-consuming and can result in cobblestone-like appearances. We devised a motorized 0.8-mm micropunch grafting procedure to overcome these limitations.To assess the therapeutic effectiveness and adverse events associated with micropunch grafting in refractory vitiligo.We retrospectively reviewed 230 cases in 208 patients with stable vitiligo who underwent motorized (...) %). Overall, the treatment was tolerable.This was a retrospective study.Micropunch grafting using a motorized 0.8-mm punch can successfully treat refractory vitiligo with short procedure times and excellent outcomes. This technique could be a rapid and convenient surgical option with acceptable adverse events and is promising for treating refractory vitiligo on an outpatient basis, particularly in patients who are unlikely to tolerate prolonged surgery.Copyright © 2018 American Academy of Dermatology, Inc

2018 Journal of American Academy of Dermatology

173. Tissue Expression of Aquaporine 3 in Different Sites of Vitiligo: An immunohistochemical study. (PubMed)

Tissue Expression of Aquaporine 3 in Different Sites of Vitiligo: An immunohistochemical study. 29729115 2018 11 29 1468-3083 32 12 2018 Dec Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Tissue expression of aquaporin 3 in different sites of vitiligo: an immunohistochemical study. e455-e456 10.1111/jdv.15049 Esmat S S Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt. Zeid O A OA Department of Dermatology

2018 Journal of the European Academy of Dermatology and Venereology

174. The Role of Interleukins in Vitiligo: a Systematic Review. (PubMed)

The Role of Interleukins in Vitiligo: a Systematic Review. Vitiligo is a disorder of the skin that causes depigmentation and asymptomatic macules whose exact cause is still unclear. Although its aetiology is not fully elucidated, the main theory of its pathomechanism is that it is associated with the autoimmune process. There is few summarized information about the role of inflammatory mediators, as interleukins, in vitiligo, so our aim was to present a systematic review of the role (...) of interleukins in vitiligo, focusing on interleukins. In this review, we included all studies assessing interleukin levels in vitiligo patients conducted up to June 2017. Quality assessment of these studies was performed using the Newcastle-Ottawa Scale (NOS). The interleukins mainly involved were IL-2, IL-4, IL-6, IL-10 and IL-17. The studies highlight the crucial role of IL-17 in the onset and progression of the disease, and its synergistic action with IL-2, IL-6 and IL-33. Dysregulated levels

2018 Journal of the European Academy of Dermatology and Venereology

175. The convergence theory for vitiligo: A reappraisal. (PubMed)

The convergence theory for vitiligo: A reappraisal. Vitiligo is characterized by progressive loss of skin pigmentation. The search for aetiologic factors has led to the biochemical, the neurologic and the autoimmune theory. The convergence theory was then proposed several years ago to incorporate existing theories of vitiligo development into a single overview of vitiligo aetiology. The viewpoint that vitiligo is not caused only by predisposing mutations, or only by melanocytes responding (...) to chemical/radiation exposure, or only by hyperreactive T cells, but rather results from a combination of aetiologic factors that impact melanocyte viability, has certainly stood the test of time. New findings have since informed the description of progressive depigmentation. Understanding the relative importance of such aetiologic factors combined with a careful selection of the most targetable pathways will continue to drive the next phase in vitiligo research: the development of effective therapeutics

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2018 Experimental Dermatology

176. Elevated total Serum IgE in vitiligo might be protective for other autoimmune diseases. (PubMed)

Elevated total Serum IgE in vitiligo might be protective for other autoimmune diseases. 29704453 2018 10 15 1365-2133 179 4 2018 Oct The British journal of dermatology Br. J. Dermatol. Elevated total serum IgE in vitiligo might be protective for other autoimmune diseases. 987-988 10.1111/bjd.16707 Marti A A Department of Dermatology, Bordeaux University Hospitals, Bordeaux, France. Taieb A A Department of Dermatology, Bordeaux University Hospitals, Bordeaux, France. INSERM U 1035, University

2018 British Journal of Dermatology

177. Risk of skin cancer in people with vitiligo: a systematic review and meta-analysis. (PubMed)

Risk of skin cancer in people with vitiligo: a systematic review and meta-analysis. 29704869 2018 10 15 1365-2133 179 4 2018 Oct The British journal of dermatology Br. J. Dermatol. Risk of skin cancer in people with vitiligo: a systematic review and meta-analysis. 971-972 10.1111/bjd.16703 Ban L L NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, U.K. Labbouz S S Nottingham University Hospitals NHS Trust

2018 British Journal of Dermatology

178. Vitiligo-like lesions in a patient treated with nivolumab for renal cell carcinoma. (PubMed)

Vitiligo-like lesions in a patient treated with nivolumab for renal cell carcinoma. The introduction of immune check-point inhibitors (ICIs) in the treatment of solid neoplasms is associated with the need to know and manage a new type of side effects that are commonly defined immune-mediated adverse events. Dermatologic immune-mediated adverse events are relatively common. Vitiligo-like lesions, defined as hypopigmented skin lesions, have already been associated with the use of ICIs (...) in particular in patients with malignant melanoma, probably due to a common autoimmune mechanism against both melanoma cells and normal melanocytes. The onset of vitiligo-like lesions is very rare in non-melanoma patients and nowadays only few cases are described in the literature.We described the case of a heavily pre-treated woman affected by renal cell carcinoma that has been treated with nivolumab for 2 years obtaining a stabilization of disease after an initial mild progression. After 9 months from

2018 Medicine

179. Evaluation of Using Fractional CO<sub>2</sub> Laser plus NB-UVB versus NB-UVB Alone in Inducing Marginal Repigmentation of Vitiligo Lesions. (PubMed)

Evaluation of Using Fractional CO2 Laser plus NB-UVB versus NB-UVB Alone in Inducing Marginal Repigmentation of Vitiligo Lesions. Vitiligo is a common depigmenting skin disorder, characterized by patchy loss of skin color and finding effective treatment has remained a challenging issue.A paired (half-body) randomized clinical trial study was done to compare the efficacy and the safety of narrowband ultraviolet B (NB-UVB) plus fractional CO2 versus NB-UVB alone in stimulation (...) of marginal repigmentation of vitiliginous patches. One side of the body was randomly treated with a fractional CO2 laser and NB-UVB twice weekly, while the other side was exposed only to NB-UVB with the same manner.Thirty patients with the non-segmental stable vitiligo and mean age of 43 ± 15 years completed a 16-week treatment period with NB-UVB on one side of the body and fractional CO2 laser therapy with NB-UBV on the other side. In addition to the higher rate of response in the combination side

2018 Journal of Dermatological Treatment

180. Involvement of non melanocytic skin cells in vitiligo. (PubMed)

Involvement of non melanocytic skin cells in vitiligo. Despite melanocytes are the key players in vitiligo, a continuous cross-talk between epidermal and dermal cells may strictly affect their functionality, in both lesional skin and non-lesional skin. Focusing on this interplay, we have reviewed existing literature supporting evidence on cellular and functional alterations of surrounding epidermal keratinocytes, extracellular matrix (ECM) proteins and fibroblasts in the underlying dermal (...) compartment that may contribute to melanocyte disappearance in vitiligo. We have also examined some clinical and therapeutic aspects of the disease to sustain the non-exclusive involvement of melanocytes within vitiligo. As a result, a different and more complex scenario has appeared that may enable to provide better understanding about origins and progress of vitiligo and that should be considered in the evaluation of new treatment approaches.© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons

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2018 Experimental Dermatology

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