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Vitiligo

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161. The early repigmentation pattern of vitiligo is related to the source of melanocytes and by the choice of therapy: a retrospective cohort study. (PubMed)

The early repigmentation pattern of vitiligo is related to the source of melanocytes and by the choice of therapy: a retrospective cohort study. Patients with vitiligo present with different repigmentation patterns in the early recovery stage.To analyze the relationships between early repigmentation patterns in vitiliginous patches, their clinical characteristics, and therapeutic choices.Patients with vitiligo seen in the Department of Dermatology, The First Affiliated Hospital of Nanjing (...) ), progressive stage (P = 0.044), and truncal lesions treated with TVDAs (P < 0.001).The different repigmentation patterns of vitiligo lesions depend on the different source and status of melanocytes and their abilities to produce melanin on the choice of therapy.© 2018 The International Society of Dermatology.

2018 International Journal of Dermatology

162. Efficacy and safety of noncultured melanocyte-keratinocyte transplant procedure for vitiligo and other leukodermas: a critical analysis of the evidence. (PubMed)

Efficacy and safety of noncultured melanocyte-keratinocyte transplant procedure for vitiligo and other leukodermas: a critical analysis of the evidence. Vitiligo is an acquired pigmentary skin of depigmentation occurring secondary to melanocyte destruction. Vitiligo and other leukodermas have a profound impact on quality of life. Current therapies include medical options, such as phototherapy, topical and systemic corticosteroids, topical calcineurin inhibitors, immunomodulators (...) , and antioxidiants, and surgical options. Surgical options provide melanocytic cells to previously depigmented areas and use either tissue grafting or cellular grafting methods. Topical treatments are often insufficient, and many of the current surgical procedures have shown variable response rates. In this review, we discuss the process of the cellular grafting melanocyte-keratinocyte transplantation procedure (MKTP) and critically analyze its efficacy and safety in the treatment of vitiligo and other

2018 International Journal of Dermatology

163. Critical appraisal of the oxidative stress pathway in vitiligo: a systematic review and meta-analysis. (PubMed)

Critical appraisal of the oxidative stress pathway in vitiligo: a systematic review and meta-analysis. The pathogenesis of vitiligo remains a topic of extensive debate. This is partly due to the moderate efficacy of current treatments. The role of the oxidative stress pathway in vitiligo is a popular although controversial research topic.To clarify the role of the oxidative stress pathway in vitiligo compared to other inflammatory skin disorders and to assess the therapeutic role (...) of antioxidants.We conducted a systematic search of the existing literature on the aberrancies of the oxidative stress pathway in vitiligo. Subsequently, the efficacy of both topical and oral antioxidants in clinical trials was investigated.A deregulated oxidative pathway is clearly evident with elevated superoxide dismutase, decreased catalase and increased lipid peroxidation. However, similar results have been obtained in other inflammatory skin diseases such as psoriasis, atopic dermatitis, lichen planus

2018 Journal of the European Academy of Dermatology and Venereology

164. Epidermal melanocytes of segmental vitiligo show altered expression of E-cadherin, but not P-cadherin. (PubMed)

Epidermal melanocytes of segmental vitiligo show altered expression of E-cadherin, but not P-cadherin. 29341072 2018 05 22 1365-2133 178 5 2018 May The British journal of dermatology Br. J. Dermatol. Epidermal melanocytes in segmental vitiligo show altered expression of E-cadherin, but not P-cadherin. 1204-1206 10.1111/bjd.16352 Grill C C Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay, France. University Paris-Sud, University

2018 British Journal of Dermatology

165. Views and experiences of seeking information and help for vitiligo: a qualitative study of written accounts. (Full text)

Views and experiences of seeking information and help for vitiligo: a qualitative study of written accounts. Vitiligo is a relatively common autoimmune condition causing loss of skin pigment. Around 1 in 100 people in the UK develop vitiligo. It can have a significant impact on quality of life for many of those affected. How people access information and help for vitiligo may influence how they manage such impact. We aimed to explore people's views and experiences of seeking health information (...) and help for vitiligo.Qualitative analysis of free-text responses to four open-ended questions in an online survey.Online survey conducted in the UK between February and March 2016.A survey link was emailed to 675 members of The Vitiligo Society, a UK-based charity providing information and support for people with vitiligo. One hundred and sixty-one members responded to the survey (24%).Many participants wrote extensive free text, often reporting frustration with help-seeking. They perceived general

2018 BMJ open

166. Vitiligo surgery: a journey from tissues via cells to the stems! (Full text)

Vitiligo surgery: a journey from tissues via cells to the stems! Depigmented patches in vitiligo, a common dermatosis, cause a great psychological distress to the patients. Hence, apart from halting the disease process, the strategies to impart normal skin colour to these white patches carry an important role in the management of vitiligo. Surgical procedures are often required for stable vitiligo lesions not responding to medical therapies. It involves "shuffling" of melanocytes from (...) the pigmented skin to the depigmented areas. During the last fifty years, the vitiligo surgery has evolved from tissue transplantation via cellular transplantation to reach a stage where the use of stem cells or immunomodulatory cells is contemplating. We would like to depict this wonderful journey of vitiligo surgery through this viewpoint.© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

2018 Experimental Dermatology

167. Association of vitiligo with hospitalization for mental health disorders in US adults. (PubMed)

Association of vitiligo with hospitalization for mental health disorders in US adults. Vitiligo has a complex bidirectional relationship with mental health (MH) disturbances. However, little is known about the relationship between vitiligo and MH emergencies.To examine the associations of vitiligo and MH hospitalizations in the United States.Data from the 2002 to 2012 National Inpatient Sample were analysed, including a ~20% sample of all US hospitalizations (n = 87 053 155 children and adults (...) ). Prevalence of hospitalization for MH disorders, their length of stay (LOS) and cost of care were determined for those with vitiligo compared to those without vitiligo.Hospitalization for MH disorders occurred more commonly in those with vitiligo compared to those without vitiligo (4.17% vs. 2.18%). In multivariable logistic regression models, vitiligo was associated with higher odds of admission for any MH disorder [adjusted odds ratio (95% confidence interval): 1.69 (1.61-1.78)], including 14 of 15 MH

2018 Journal of the European Academy of Dermatology and Venereology

168. Association Between Psoriasis and Vitiligo: A Systematic Review and Meta-Analysis. (PubMed)

Association Between Psoriasis and Vitiligo: A Systematic Review and Meta-Analysis. The relationship between psoriasis and vitiligo has not been previously confirmed, and we therefore aimed to investigate this association.We conducted a search of the MEDLINE and EMBASE electronic databases on 22 January 2018 for case-control, cross-sectional, and cohort studies examining the association between psoriasis and vitiligo. A customized Newcastle-Ottawa Scale was used to assess the risk of bias (...) of the included studies. We performed a random effects meta-analysis to calculate pooled odds ratios (ORs) with 95% confidence intervals (CIs) for case-control and cross-sectional studies.Of 2453 citations identified from the literature search, 10 case-control/cross-sectional studies with a total of 120,866 psoriasis cases and 79,907 vitiligo cases were included in our study. Four of these studies were rated as high risk of bias. We found a significantly increased odds for vitiligo in psoriasis patients

2018 American journal of clinical dermatology

169. Habits and Risk Perception Associated with Sun Exposure in Vitiligo Patients according to their participation in a patients' organization. (PubMed)

Habits and Risk Perception Associated with Sun Exposure in Vitiligo Patients according to their participation in a patients' organization. 30284740 2019 03 20 1468-3083 33 3 2019 Mar Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Habits and risk perception associated with sun exposure in vitiligo patients according to their participation in a patients' organization. e100-e103 10.1111/jdv.15264 Bhatia B B Department of Dermatology, Henry Ford (...) Hospital, Detroit, MI, USA. Kechichian E E Department of Dermatology, CHU Henri Mondor, Créteil, France. Eleftheriadou V V Centre of Evidence Based Dermatology, Kings Meadow Campus, University of Nottingham, Nottingham, UK. Castelneau J-P JP Department of Dermatology, CHU Henri Mondor, Créteil, France. Seité S S La Roche-Posay Laboratoire Dermatologique, Paris, France. Meurant J-M JM Association Française du Vitiligo, Paris, France. Hamzavi I I Department of Dermatology, Henry Ford Hospital, Detroit

2018 Journal of the European Academy of Dermatology and Venereology

170. A comparative study between suction blistering graft, mini punch graft and hair follicle transplant in treatment of patients with stable vitiligo. (PubMed)

A comparative study between suction blistering graft, mini punch graft and hair follicle transplant in treatment of patients with stable vitiligo. Vitiligo is an acquired disfiguring common depigmented skin disease.This study aimed to compare the clinical efficacy and safety of suction blistering graft, mini punch and hair follicle techniques in treatment of patients with stable vitiligo.Thirty patients with stable vitiligo were included. Patients were divided into 3 groups, in group (A) 10 (...) patient underwent suction blistering technique, in group (B) 10 patients underwent mini punch technique and in group (C) 10 patients underwent hair follicle technique. Then all patients in the three techniques were subjected to narrow-band ultraviolet B (NB-UVB) phototherapy for 3 months. All patients were assessed by determining the percentage of repigmentation and Dermatology Life Quality Index (DLQI) before and 3 months after the operation.The percentage of repigmentation of vitiligo in suction

2018 Journal of Dermatological Treatment

171. Activation of melanoblasts and melanocytes after treatment with monochromatic excimer light and narrowband-ultraviolet B of skin of vitiligo patients. (PubMed)

Activation of melanoblasts and melanocytes after treatment with monochromatic excimer light and narrowband-ultraviolet B of skin of vitiligo patients. Vitiligo is a hypopigmentation disease characterized by achromatic or hypochromatic macules in several sites of human skin. Although monochromatic excimer light (MEL) and narrowband-ultraviolet B (NB-UVB) have recently been used for efficacious treatment of vitiligo, the repigmentation process and role of melanocytes/melanoblasts are not well (...) known.White macules of 28 vitiligo patients were repeatedly exposed with MEL/NB-UVB. After the exposures, punch biopsies of the center and edge of the lesional skin in addition to normal skin were fixed and processed to dopa and combined dopa-premelanin reactions. Melanocytes positive to the dopa reaction and melanoblasts/melanocytes positive to the combined dopa-premelanin reaction were surveyed.Two repigmentation patterns were observed; one was "marginal" and the other was "perifollicular." Although

2018 International Journal of Dermatology

172. Reference method for digital surface measurement of target lesions in vitiligo: a comparative analysis. (PubMed)

Reference method for digital surface measurement of target lesions in vitiligo: a comparative analysis. Objective measurement of target lesions in vitiligo is important for clinical practice and trials, yet no preferred tool has been defined. Reported digital tools have shortcomings related to feasibility aspects and often lack information on validity, reliability and responsiveness. Moreover, studies are not yet based on ultraviolet (UV) photography.To assess the reliability, validity (...) and feasibility of two functions in ImageJ for measurement of target lesions, based on three different types of images including UV pictures.Planimetric measurements were performed on photographs with and without UV, and lesion contours on transparent sheets of 52 vitiligo lesions from 10 patients with vitiligo. The ImageJ functions 'wand' and 'threshold' were used by three and four assessors, respectively. Inter- and intrarater reliability, hypothesis testing for construct validity, and feasibility were

2018 British Journal of Dermatology

173. Four compartment method as an efficacious and simplified technique for autologous non-cultured epidermal cell suspension preparation in vitiligo surgery: A randomized, active-controlled study. (Full text)

Four compartment method as an efficacious and simplified technique for autologous non-cultured epidermal cell suspension preparation in vitiligo surgery: A randomized, active-controlled study. Autologous non-cultured epidermal cell suspension (NCES) is a successful surgical method for repigmentation of stable, refractory vitiligo. The need for laboratory equipment and expertise restricts its use to only a few research centres; hence, there is a requisite to simplify the technique of NCES (...) preparation.To evaluate the efficacy of NCES prepared by four compartment (4C) method compared to the laboratory-based method (lab-NCES).Anatomically based matched lesions (41 pairs) in 30 stable vitiligo patients were randomized to receive NCES prepared by 4C method or lab-NCES. Each patient was evaluated at 4, 8, 16 weeks after surgery by a blinded observer with regard to extent of repigmentation, colour match, patient global assessment (PGA) and pattern of repigmentation.Repigmentation outcome in 4C

2018 Journal of the European Academy of Dermatology and Venereology Controlled trial quality: uncertain

174. Serum homocysteine, folate, and vitamin B<sub>12</sub> levels in patients with vitiligo and their potential roles as disease activity biomarkers: A systematic review and meta-analysis. (PubMed)

Serum homocysteine, folate, and vitamin B12 levels in patients with vitiligo and their potential roles as disease activity biomarkers: A systematic review and meta-analysis. Hyperhomocysteinemia and folate and vitamin B12 deficiencies have been reported in patients with vitiligo. Investigating the role of these conditions might shed light on the pathogenesis of vitiligo.To perform a systematic review and meta-analysis of studies assessing serum homocysteine, folate, and vitamin B12 (...) levels in vitiligo patients.Online databases were searched on May 15, 2018, to identify studies comparing serum homocysteine, folate, and vitamin B12 levels between patients with vitiligo and controls. A random effects model was used.Twenty-two studies involving a total of 1448 patients with vitiligo were included. Patients with vitiligo had significantly higher serum homocysteine levels (standardized mean difference [SMD] 0.550, 95% confidence interval [CI] 0.262-0.838; I2 87.3%) and lower vitamin

2018 Journal of American Academy of Dermatology

175. Laser Ablation of the Recipient Area With Platelet-Rich Plasma-Enriched Epidermal Suspension Transplant in Vitiligo Surgery: A Pilot Study. (PubMed)

Laser Ablation of the Recipient Area With Platelet-Rich Plasma-Enriched Epidermal Suspension Transplant in Vitiligo Surgery: A Pilot Study. Noncultured epidermal cell suspension transplantation is a very popular surgical modality for treating vitiligo. However, the procedure can be modified to improve results.To study the extent of repigmentation with noncultured trypsinized fragmented epidermal suspension using platelet-rich plasma (PRP) as a suspending agent and pixel erbium yttrium aluminium (...) garnet laser for ablation of recipient area in patients with stable vitiligo.Autologous noncultured tiny epidermal fragments suspended in PRP were grafted on superficially pixel erbium YAG laser-ablated vitiligo lesions in 10 patients. The repigmentation was evaluated over a period of 6 months using a digital image analysis system.Repigmentation was observed as early as 2 weeks after the treatment. Of 20 lesions, 12 (60%) showed excellent response; of which 10 lesions (50%) showed complete

2018 Dermatologic Surgery

176. Addition of oral mini pulse dexamethasone to NBUVB phototherapy and topical steroids helps arrest disease activity in patients with vitiligo. (Full text)

Addition of oral mini pulse dexamethasone to NBUVB phototherapy and topical steroids helps arrest disease activity in patients with vitiligo. 30188576 2019 01 03 1365-2133 180 1 2019 Jan The British journal of dermatology Br. J. Dermatol. Addition of oral minipulse dexamethasone to narrowband ultraviolet B phototherapy and topical steroids helps arrest disease activity in patients with vitiligo. 193-194 10.1111/bjd.17150 Tovar-Garza A A Department of Dermatology, University of Texas

2018 British Journal of Dermatology

177. Decreased expression of neuregulin1 in the lesional skin of vitiligo patients. (PubMed)

Decreased expression of neuregulin1 in the lesional skin of vitiligo patients. Paracrine cross-talk exists between the fibroblasts of dermis and epidermal cells through secretions of various growth factors. Melanocytes present at the basement layer of the epidermis and respond to various factors secreted by underlying dermal fibroblasts in the dermis to regulate the function of the skin.Therefore the study was planned to check the expression of fibroblast-derived factor neuregulin1 (NRG1 (...) ) in vitiligo skin and its effect on melanocytes.For this study, relative gene expression at mRNA level of NRG1 in the vitiligo skin was analyzed by qRT-PCR, and protein analysis was done by immunohistochemistry. Effect of different concentrations of NRG1 was checked on the cultured melanocytes by melanin content assay, proliferation assay, and tyrosinase (TYR) assay. The effect of NRG1 was also checked on the level of melanocyte regulatory genes (MITF, c-KIT, TYR, DCT).Expression of NRG1 was significantly

2018 International Journal of Dermatology

178. Role of IL-17A receptor blocking in melanocytes survival: A strategic intervention against vitiligo. (Full text)

Role of IL-17A receptor blocking in melanocytes survival: A strategic intervention against vitiligo. Cytokines regulate immune response and inflammation and play an important role in depigmentation process of an autoimmune disease, vitiligo. We sought to determine how inflammatory cytokines influence the progression of vitiligo, and based on that, we develop a logical therapeutic intervention using primary melanocyte culture. Melanocytes were cultured and exposed to IL-17A, IL-1β, IFN-γ and TGF

2018 Experimental Dermatology

179. Clinical Application of Cultured Stratified Epithelial Sheets Grown Under Feeder or Feeder-Free Conditions for Stable Vitiligo. (PubMed)

Clinical Application of Cultured Stratified Epithelial Sheets Grown Under Feeder or Feeder-Free Conditions for Stable Vitiligo. Autologous cultured therapy has emerged as an effective treatment for stable vitiligo. However, culture methods may include harmful agents and be unsuitable for therapeutic use in humans.To investigate the safety and efficacy of autologous cultured epithelial sheets propagated under serum-free and feeder-free conditions for the treatment of stable vitiligo.Twenty-eight (...) patients with stable vitiligo were included in this study. Keratinocytes and melanocytes from 14 patients were cultured under serum-free, feeder-free conditions (Group A). Epithelial cells from the remaining 14 patients were cultured according to Rheinward and Green's technique (Group B). Patients were followed up at 1, 3, 6, and 12 months after transplantation.The epithelial sheets cultured in Group A were thinner and more fragile than Group B, but there were no significant differences

2018 Dermatologic Surgery

180. Ablative fractional Co<sub>2</sub> laser aided delivery of long-acting glucocorticoid in the treatment of acral vitiligo: A multicenter, prospective, self- bilateral controlled study. (PubMed)

Ablative fractional Co2 laser aided delivery of long-acting glucocorticoid in the treatment of acral vitiligo: A multicenter, prospective, self- bilateral controlled study. Acral vitiligo often responses poorly to treatments.To observe whether pretreatment with ablative fractional CO2 laser aiding penetration of compound betamethasone solution plus NB-UVB could improve the response of refractory acral vitiligo.Subjects with symmetrical and stable acral vitiligo were enrolled (...) eighty-nine subjects entered the clinical trial and 126 subjects completed the study. The experiment side showed better improvement in repigmentation. Overall response rate (repigmentation percentage ≥10%) of experiment sides was 51.6%, in contrast, that of control side was 35.8%. There were no severe adverse events in all subjects during the trial.A triple method of ablative fractional CO2 laser, topical compound betamethasone solution plus NB-UVB provided an alternative choice for acral vitiligo

2018 Journal of Dermatological Treatment Controlled trial quality: uncertain

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