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Vitiligo

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141. Combination of Follicular and Epidermal Cell Suspension as a Novel Surgical Approach in Difficult-to-Treat Vitiligo: A Randomized Clinical Trial. Full Text available with Trip Pro

Combination of Follicular and Epidermal Cell Suspension as a Novel Surgical Approach in Difficult-to-Treat Vitiligo: A Randomized Clinical Trial. Epidermal cell suspension (ECS) and follicular cell suspension (FCS) are successful surgical modalities for the treatment of stable vitiligo. However, repigmentation in generalized and acrofacial vitiligo and over acral or bony sites (eg, elbows, knees, iliac crests, and malleoli), which are difficult to treat, is challenging.To study the efficacy (...) of transplanting a combination of autologous, noncultured ECS and FCS (ECS + FCS) compared with ECS alone in stable vitiligo.A prospective, observer-blinded, active-controlled, randomized clinical trial was conducted at a tertiary care hospital, with treatment administered as an outpatient procedure. Thirty participants who had stable vitiligo with symmetrical lesions were recruited between October 18, 2013, and October 28, 2016. All of the lesions were resistant to medical modalities with minimum lesional

2018 JAMA dermatology (Chicago, Ill.) Controlled trial quality: uncertain

142. Once weekly targeted excimer light produced modest re-pigmentation of vitiligo over a 20-week period. (Abstract)

Once weekly targeted excimer light produced modest re-pigmentation of vitiligo over a 20-week period. 29419905 2018 03 05 1468-3083 2018 Feb 08 Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Once weekly targeted excimer light produced modest repigmentation of vitiligo over a 20-week period. 10.1111/jdv.14853 Ayob S S Department of Dermatology, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK. Cockayne S E SE Department of Dermatology, Royal

2018 Journal of the European Academy of Dermatology and Venereology

143. Tissue Expression of Aquaporine 3 in Different Sites of Vitiligo: An immunohistochemical study. (Abstract)

Tissue Expression of Aquaporine 3 in Different Sites of Vitiligo: An immunohistochemical study. 29729115 2018 11 29 1468-3083 32 12 2018 Dec Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Tissue expression of aquaporin 3 in different sites of vitiligo: an immunohistochemical study. e455-e456 10.1111/jdv.15049 Esmat S S Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt. Zeid O A OA Department of Dermatology

2018 Journal of the European Academy of Dermatology and Venereology

144. Vitiligo remitting with tocilizumab. (Abstract)

Vitiligo remitting with tocilizumab. 29888453 2019 01 18 1468-3083 33 1 2019 Jan Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Vitiligo remitting with tocilizumab. e20 10.1111/jdv.15117 Bunker C B CB University College London Hospitals, 250 Euston Road, London, NW1 2AF, UK. Manson J J University College London Hospitals, 250 Euston Road, London, NW1 2AF, UK. eng Letter 2018 06 28 England J Eur Acad Dermatol Venereol 9216037 0926-9959 2018 6

2018 Journal of the European Academy of Dermatology and Venereology

145. Decreased choroidal thickness in vitiligo patients. Full Text available with Trip Pro

Decreased choroidal thickness in vitiligo patients. Vitiligo is a disease characterized by depigmented macules and patches that occur as a result of the loss of functional melanocytes from the affected skin through a mechanism which has not been elucidated yet. Destruction of pigment cells in vitiligo may not remain limited to the skin; the eyelashes, iris, ciliary body, choroid, retinal pigment epithelium and meninges may also be affected. This study aims to compare the choroidal thickness (...) of patients with and without vitiligo using optical coherence tomography (OCT).Spectral-domain optical coherence tomography (SD-OCT) (Retina Scan Advanced RS-3000 NIDEK, Japan) instrument (with λ = 840 nm, 27,000 A-scans/second and 5 μm axial resolution) was used for the imaging. Statistical analysis was performed using SPSS 21.0 software package.In all values except optic nevre area measurements, the choroidal thickness of all vitiligo patients was found out to be thinner compared to the control group.In

2018 BMC Ophthalmology

146. Predictive Model for Response Rate to Narrowband Ultraviolet B Phototherapy in Vitiligo: A Retrospective Cohort Study of 579 Patients. Full Text available with Trip Pro

Predictive Model for Response Rate to Narrowband Ultraviolet B Phototherapy in Vitiligo: A Retrospective Cohort Study of 579 Patients. Vitiligo is an acquired depigmenting disorder. To date, there is no predictive model for its response rate to narrowband ultraviolet B (NBUVB) phototherapy. The aim of this study was to investigate the different types of response of patients with non-segmental vitiligo undergoing NBUVB 3 times a week. Many patients who were previously considered non-responders

2018 Acta Dermato-Venereologica

147. The early repigmentation pattern of vitiligo is related to the source of melanocytes and by the choice of therapy: a retrospective cohort study. (Abstract)

The early repigmentation pattern of vitiligo is related to the source of melanocytes and by the choice of therapy: a retrospective cohort study. Patients with vitiligo present with different repigmentation patterns in the early recovery stage.To analyze the relationships between early repigmentation patterns in vitiliginous patches, their clinical characteristics, and therapeutic choices.Patients with vitiligo seen in the Department of Dermatology, The First Affiliated Hospital of Nanjing (...) ), progressive stage (P = 0.044), and truncal lesions treated with TVDAs (P < 0.001).The different repigmentation patterns of vitiligo lesions depend on the different source and status of melanocytes and their abilities to produce melanin on the choice of therapy.© 2018 The International Society of Dermatology.

2018 International Journal of Dermatology

148. Efficacy and safety of noncultured melanocyte-keratinocyte transplant procedure for vitiligo and other leukodermas: a critical analysis of the evidence. (Abstract)

Efficacy and safety of noncultured melanocyte-keratinocyte transplant procedure for vitiligo and other leukodermas: a critical analysis of the evidence. Vitiligo is an acquired pigmentary skin of depigmentation occurring secondary to melanocyte destruction. Vitiligo and other leukodermas have a profound impact on quality of life. Current therapies include medical options, such as phototherapy, topical and systemic corticosteroids, topical calcineurin inhibitors, immunomodulators (...) , and antioxidiants, and surgical options. Surgical options provide melanocytic cells to previously depigmented areas and use either tissue grafting or cellular grafting methods. Topical treatments are often insufficient, and many of the current surgical procedures have shown variable response rates. In this review, we discuss the process of the cellular grafting melanocyte-keratinocyte transplantation procedure (MKTP) and critically analyze its efficacy and safety in the treatment of vitiligo and other

2018 International Journal of Dermatology

149. Critical appraisal of the oxidative stress pathway in vitiligo: a systematic review and meta-analysis. (Abstract)

Critical appraisal of the oxidative stress pathway in vitiligo: a systematic review and meta-analysis. The pathogenesis of vitiligo remains a topic of extensive debate. This is partly due to the moderate efficacy of current treatments. The role of the oxidative stress pathway in vitiligo is a popular although controversial research topic.To clarify the role of the oxidative stress pathway in vitiligo compared to other inflammatory skin disorders and to assess the therapeutic role (...) of antioxidants.We conducted a systematic search of the existing literature on the aberrancies of the oxidative stress pathway in vitiligo. Subsequently, the efficacy of both topical and oral antioxidants in clinical trials was investigated.A deregulated oxidative pathway is clearly evident with elevated superoxide dismutase, decreased catalase and increased lipid peroxidation. However, similar results have been obtained in other inflammatory skin diseases such as psoriasis, atopic dermatitis, lichen planus

2018 Journal of the European Academy of Dermatology and Venereology

150. Epidermal melanocytes of segmental vitiligo show altered expression of E-cadherin, but not P-cadherin. (Abstract)

Epidermal melanocytes of segmental vitiligo show altered expression of E-cadherin, but not P-cadherin. 29341072 2018 05 22 1365-2133 178 5 2018 May The British journal of dermatology Br. J. Dermatol. Epidermal melanocytes in segmental vitiligo show altered expression of E-cadherin, but not P-cadherin. 1204-1206 10.1111/bjd.16352 Grill C C Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay, France. University Paris-Sud, University

2018 British Journal of Dermatology

151. Views and experiences of seeking information and help for vitiligo: a qualitative study of written accounts. Full Text available with Trip Pro

Views and experiences of seeking information and help for vitiligo: a qualitative study of written accounts. Vitiligo is a relatively common autoimmune condition causing loss of skin pigment. Around 1 in 100 people in the UK develop vitiligo. It can have a significant impact on quality of life for many of those affected. How people access information and help for vitiligo may influence how they manage such impact. We aimed to explore people's views and experiences of seeking health information (...) and help for vitiligo.Qualitative analysis of free-text responses to four open-ended questions in an online survey.Online survey conducted in the UK between February and March 2016.A survey link was emailed to 675 members of The Vitiligo Society, a UK-based charity providing information and support for people with vitiligo. One hundred and sixty-one members responded to the survey (24%).Many participants wrote extensive free text, often reporting frustration with help-seeking. They perceived general

2018 BMJ open

152. Vitiligo surgery: a journey from tissues via cells to the stems! Full Text available with Trip Pro

Vitiligo surgery: a journey from tissues via cells to the stems! Depigmented patches in vitiligo, a common dermatosis, cause a great psychological distress to the patients. Hence, apart from halting the disease process, the strategies to impart normal skin colour to these white patches carry an important role in the management of vitiligo. Surgical procedures are often required for stable vitiligo lesions not responding to medical therapies. It involves "shuffling" of melanocytes from (...) the pigmented skin to the depigmented areas. During the last fifty years, the vitiligo surgery has evolved from tissue transplantation via cellular transplantation to reach a stage where the use of stem cells or immunomodulatory cells is contemplating. We would like to depict this wonderful journey of vitiligo surgery through this viewpoint.© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

2018 Experimental Dermatology

153. Association of vitiligo with hospitalization for mental health disorders in US adults. (Abstract)

Association of vitiligo with hospitalization for mental health disorders in US adults. Vitiligo has a complex bidirectional relationship with mental health (MH) disturbances. However, little is known about the relationship between vitiligo and MH emergencies.To examine the associations of vitiligo and MH hospitalizations in the United States.Data from the 2002 to 2012 National Inpatient Sample were analysed, including a ~20% sample of all US hospitalizations (n = 87 053 155 children and adults (...) ). Prevalence of hospitalization for MH disorders, their length of stay (LOS) and cost of care were determined for those with vitiligo compared to those without vitiligo.Hospitalization for MH disorders occurred more commonly in those with vitiligo compared to those without vitiligo (4.17% vs. 2.18%). In multivariable logistic regression models, vitiligo was associated with higher odds of admission for any MH disorder [adjusted odds ratio (95% confidence interval): 1.69 (1.61-1.78)], including 14 of 15 MH

2018 Journal of the European Academy of Dermatology and Venereology

154. Association Between Psoriasis and Vitiligo: A Systematic Review and Meta-Analysis. (Abstract)

Association Between Psoriasis and Vitiligo: A Systematic Review and Meta-Analysis. The relationship between psoriasis and vitiligo has not been previously confirmed, and we therefore aimed to investigate this association.We conducted a search of the MEDLINE and EMBASE electronic databases on 22 January 2018 for case-control, cross-sectional, and cohort studies examining the association between psoriasis and vitiligo. A customized Newcastle-Ottawa Scale was used to assess the risk of bias (...) of the included studies. We performed a random effects meta-analysis to calculate pooled odds ratios (ORs) with 95% confidence intervals (CIs) for case-control and cross-sectional studies.Of 2453 citations identified from the literature search, 10 case-control/cross-sectional studies with a total of 120,866 psoriasis cases and 79,907 vitiligo cases were included in our study. Four of these studies were rated as high risk of bias. We found a significantly increased odds for vitiligo in psoriasis patients

2018 American journal of clinical dermatology

155. Habits and Risk Perception Associated with Sun Exposure in Vitiligo Patients according to their participation in a patients' organization. (Abstract)

Habits and Risk Perception Associated with Sun Exposure in Vitiligo Patients according to their participation in a patients' organization. 30284740 2019 03 20 1468-3083 33 3 2019 Mar Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Habits and risk perception associated with sun exposure in vitiligo patients according to their participation in a patients' organization. e100-e103 10.1111/jdv.15264 Bhatia B B Department of Dermatology, Henry Ford (...) Hospital, Detroit, MI, USA. Kechichian E E Department of Dermatology, CHU Henri Mondor, Créteil, France. Eleftheriadou V V Centre of Evidence Based Dermatology, Kings Meadow Campus, University of Nottingham, Nottingham, UK. Castelneau J-P JP Department of Dermatology, CHU Henri Mondor, Créteil, France. Seité S S La Roche-Posay Laboratoire Dermatologique, Paris, France. Meurant J-M JM Association Française du Vitiligo, Paris, France. Hamzavi I I Department of Dermatology, Henry Ford Hospital, Detroit

2018 Journal of the European Academy of Dermatology and Venereology

156. A comparative study between suction blistering graft, mini punch graft and hair follicle transplant in treatment of patients with stable vitiligo. (Abstract)

A comparative study between suction blistering graft, mini punch graft and hair follicle transplant in treatment of patients with stable vitiligo. Vitiligo is an acquired disfiguring common depigmented skin disease.This study aimed to compare the clinical efficacy and safety of suction blistering graft, mini punch and hair follicle techniques in treatment of patients with stable vitiligo.Thirty patients with stable vitiligo were included. Patients were divided into 3 groups, in group (A) 10 (...) patient underwent suction blistering technique, in group (B) 10 patients underwent mini punch technique and in group (C) 10 patients underwent hair follicle technique. Then all patients in the three techniques were subjected to narrow-band ultraviolet B (NB-UVB) phototherapy for 3 months. All patients were assessed by determining the percentage of repigmentation and Dermatology Life Quality Index (DLQI) before and 3 months after the operation.The percentage of repigmentation of vitiligo in suction

2018 Journal of Dermatological Treatment

157. Activation of melanoblasts and melanocytes after treatment with monochromatic excimer light and narrowband-ultraviolet B of skin of vitiligo patients. (Abstract)

Activation of melanoblasts and melanocytes after treatment with monochromatic excimer light and narrowband-ultraviolet B of skin of vitiligo patients. Vitiligo is a hypopigmentation disease characterized by achromatic or hypochromatic macules in several sites of human skin. Although monochromatic excimer light (MEL) and narrowband-ultraviolet B (NB-UVB) have recently been used for efficacious treatment of vitiligo, the repigmentation process and role of melanocytes/melanoblasts are not well (...) known.White macules of 28 vitiligo patients were repeatedly exposed with MEL/NB-UVB. After the exposures, punch biopsies of the center and edge of the lesional skin in addition to normal skin were fixed and processed to dopa and combined dopa-premelanin reactions. Melanocytes positive to the dopa reaction and melanoblasts/melanocytes positive to the combined dopa-premelanin reaction were surveyed.Two repigmentation patterns were observed; one was "marginal" and the other was "perifollicular." Although

2018 International Journal of Dermatology

158. Reference method for digital surface measurement of target lesions in vitiligo: a comparative analysis. (Abstract)

Reference method for digital surface measurement of target lesions in vitiligo: a comparative analysis. Objective measurement of target lesions in vitiligo is important for clinical practice and trials, yet no preferred tool has been defined. Reported digital tools have shortcomings related to feasibility aspects and often lack information on validity, reliability and responsiveness. Moreover, studies are not yet based on ultraviolet (UV) photography.To assess the reliability, validity (...) and feasibility of two functions in ImageJ for measurement of target lesions, based on three different types of images including UV pictures.Planimetric measurements were performed on photographs with and without UV, and lesion contours on transparent sheets of 52 vitiligo lesions from 10 patients with vitiligo. The ImageJ functions 'wand' and 'threshold' were used by three and four assessors, respectively. Inter- and intrarater reliability, hypothesis testing for construct validity, and feasibility were

2018 British Journal of Dermatology

159. Four compartment method as an efficacious and simplified technique for autologous non-cultured epidermal cell suspension preparation in vitiligo surgery: A randomized, active-controlled study. Full Text available with Trip Pro

Four compartment method as an efficacious and simplified technique for autologous non-cultured epidermal cell suspension preparation in vitiligo surgery: A randomized, active-controlled study. Autologous non-cultured epidermal cell suspension (NCES) is a successful surgical method for repigmentation of stable, refractory vitiligo. The need for laboratory equipment and expertise restricts its use to only a few research centres; hence, there is a requisite to simplify the technique of NCES (...) preparation.To evaluate the efficacy of NCES prepared by four compartment (4C) method compared to the laboratory-based method (lab-NCES).Anatomically based matched lesions (41 pairs) in 30 stable vitiligo patients were randomized to receive NCES prepared by 4C method or lab-NCES. Each patient was evaluated at 4, 8, 16 weeks after surgery by a blinded observer with regard to extent of repigmentation, colour match, patient global assessment (PGA) and pattern of repigmentation.Repigmentation outcome in 4C

2018 Journal of the European Academy of Dermatology and Venereology Controlled trial quality: uncertain

160. Serum homocysteine, folate, and vitamin B<sub>12</sub> levels in patients with vitiligo and their potential roles as disease activity biomarkers: A systematic review and meta-analysis. (Abstract)

Serum homocysteine, folate, and vitamin B12 levels in patients with vitiligo and their potential roles as disease activity biomarkers: A systematic review and meta-analysis. Hyperhomocysteinemia and folate and vitamin B12 deficiencies have been reported in patients with vitiligo. Investigating the role of these conditions might shed light on the pathogenesis of vitiligo.To perform a systematic review and meta-analysis of studies assessing serum homocysteine, folate, and vitamin B12 (...) levels in vitiligo patients.Online databases were searched on May 15, 2018, to identify studies comparing serum homocysteine, folate, and vitamin B12 levels between patients with vitiligo and controls. A random effects model was used.Twenty-two studies involving a total of 1448 patients with vitiligo were included. Patients with vitiligo had significantly higher serum homocysteine levels (standardized mean difference [SMD] 0.550, 95% confidence interval [CI] 0.262-0.838; I2 87.3%) and lower vitamin

2018 Journal of American Academy of Dermatology

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