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Vitiligo

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141. Genetic polymorphisms of GZMB and vitiligo: A genetic association study based on Chinese Han population (PubMed)

Genetic polymorphisms of GZMB and vitiligo: A genetic association study based on Chinese Han population Vitiligo is a skin disease that affects 1% of the population worldwide. Both environmental and genetic factors contribute to the risk of vitiligo. GZMB encodes the enzyme Granzyme B, which plays an important role in cytotoxic T cell-induced apoptosis, and it has been considered one of the candidate genes for vitiligo because of its connections with human immune system. Overall, 3,120 study (...) subjects with Chinese Han ancestry were recruited, and 15 pre-selected SNPs of GZMB were genotyped. Genetic association analyses were performed to evaluate the genetic risk of these SNPs to vitiligo. Further bioinformatic analyses were conducted to examine the potential biological function of targeted SNPs. The SNP rs8192917, a non-synonymous coding SNP, was identified to be significantly associated with the disease status of vitiligo, with OR = 1.39 and P = 1.92 × 10-8. Differences in the association

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2018 Scientific reports

142. Potential anti-vitiligo properties of cynarine extracted from Vernonia anthelmintica (L.) Willd (PubMed)

Potential anti-vitiligo properties of cynarine extracted from Vernonia anthelmintica (L.) Willd Vitiligo is a depigmentation disorder of the skin. It is primarily caused by the destruction of melanocytes or obstruction of the melanin synthesis pathway. Melanin is a type of skin pigment that determines skin color. The seeds of Vernonia anthelmintica (L.) Willd (Kaliziri) are used for treating skin diseases including vitiligo in traditional Uyghur medicine. 1,5‑Dicaffeoylquinic acid (1,5‑diCQA (...) induced by 1,5‑diCQA treatment were significantly attenuated by the protein kinase A (PKA) inhibitor H‑89. Intracellular cyclic adenosine monophosphate (cAMP) concentration and phosphorylation of cAMP‑response element binding protein was increased following 1,5‑diCQA treatment. These results indicated that 1,5‑diCQA stimulated melanogenesis via the MAPK and cAMP/PKA signaling pathways in B16 cells, which has potential therapeutic implications for vitiligo.

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2018 International journal of molecular medicine

143. Resident memory and recirculating memory T cells cooperate to maintain disease in a mouse model of vitiligo. (PubMed)

Resident memory and recirculating memory T cells cooperate to maintain disease in a mouse model of vitiligo. Tissue resident memory T cells (Trm) form in the skin in vitiligo and persist to maintain disease, as white spots often recur rapidly after discontinuing therapy. We and others have recently described melanocyte-specific autoreactive Trm in vitiligo lesions. Here, we characterize the functional relationship between Trm and recirculating memory T cells (Tcm) in our vitiligo mouse model (...) . We found that both Trm and Tcm sensed autoantigen in the skin long after stabilization of disease, producing IFN-γ, CXCL9, and CXCL10. Blockade of Tcm recruitment to the skin with FTY720 or depletion of Tcm with low-dose Thy1.1 antibody reversed disease, indicating that Trm cooperate with Tcm to maintain disease. Taken together, our data provide characterization of skin memory T cells in vitiligo, demonstrate that Trm and Tcm work together during disease, and indicate that targeting

2018 Journal of Investigative Dermatology

144. Vitiligo after alemtuzumab treatment: Secondary autoimmunity is not all about B cells. (PubMed)

Vitiligo after alemtuzumab treatment: Secondary autoimmunity is not all about B cells. To report 3 patients with relapsing-remitting multiple sclerosis (RRMS) showing vitiligo after treatment with alemtuzumab.Retrospective case series including flow cytometric analyses and T-cell receptor (TCR) sequencing of peripheral blood mononuclear cells.We describe 3 cases of alemtuzumab-treated patients with RRMS developing vitiligo 52, 18, and 14 months after alemtuzumab initiation. Histopathology shows (...) loss of epidermal pigmentation with absence of melanocytes and interface dermatitis with CD8+ T-cell infiltration. Also compatible with pathophysiologic concepts of vitiligo, peripheral blood mononuclear cells of one patient showed high proportions of CD8+ T cells with an activated (human leukocyte antigen-DR+), memory (CD45RO+), and type 1 cytokine (interferon-γ + tumor necrosis factor-α) phenotype at vitiligo onset compared to a control cohort of alemtuzumab-treated patients with RRMS (n = 30

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2018 Neurology

145. Four compartment method as an efficacious and simplified technique for autologous non-cultured epidermal cell suspension preparation in vitiligo surgery: A randomized, active-controlled study. (PubMed)

Four compartment method as an efficacious and simplified technique for autologous non-cultured epidermal cell suspension preparation in vitiligo surgery: A randomized, active-controlled study. Autologous non-cultured epidermal cell suspension (NCES) is a successful surgical method for repigmentation of stable, refractory vitiligo. The need for laboratory equipment and expertise restricts its use to only a few research centres; hence, there is a requisite to simplify the technique of NCES (...) preparation.To evaluate the efficacy of NCES prepared by four compartment (4C) method compared to the laboratory-based method (lab-NCES).Anatomically based matched lesions (41 pairs) in 30 stable vitiligo patients were randomized to receive NCES prepared by 4C method or lab-NCES. Each patient was evaluated at 4, 8, 16 weeks after surgery by a blinded observer with regard to extent of repigmentation, colour match, patient global assessment (PGA) and pattern of repigmentation.Repigmentation outcome in 4C

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2018 Journal of the European Academy of Dermatology and Venereology

146. Serum homocysteine, folate, and vitamin B<sub>12</sub> levels in patients with vitiligo and their potential roles as disease activity biomarkers: A systematic review and meta-analysis. (PubMed)

Serum homocysteine, folate, and vitamin B12 levels in patients with vitiligo and their potential roles as disease activity biomarkers: A systematic review and meta-analysis. Hyperhomocysteinemia and folate and vitamin B12 deficiencies have been reported in patients with vitiligo. Investigating the role of these conditions might shed light on the pathogenesis of vitiligo.To perform a systematic review and meta-analysis of studies assessing serum homocysteine, folate, and vitamin B12 (...) levels in vitiligo patients.Online databases were searched on May 15, 2018, to identify studies comparing serum homocysteine, folate, and vitamin B12 levels between patients with vitiligo and controls. A random effects model was used.Twenty-two studies involving a total of 1448 patients with vitiligo were included. Patients with vitiligo had significantly higher serum homocysteine levels (standardized mean difference [SMD] 0.550, 95% confidence interval [CI] 0.262-0.838; I2 87.3%) and lower vitamin

2018 Journal of American Academy of Dermatology

147. Decreased expression of neuregulin1 in the lesional skin of vitiligo patients. (PubMed)

Decreased expression of neuregulin1 in the lesional skin of vitiligo patients. Paracrine cross-talk exists between the fibroblasts of dermis and epidermal cells through secretions of various growth factors. Melanocytes present at the basement layer of the epidermis and respond to various factors secreted by underlying dermal fibroblasts in the dermis to regulate the function of the skin.Therefore the study was planned to check the expression of fibroblast-derived factor neuregulin1 (NRG1 (...) ) in vitiligo skin and its effect on melanocytes.For this study, relative gene expression at mRNA level of NRG1 in the vitiligo skin was analyzed by qRT-PCR, and protein analysis was done by immunohistochemistry. Effect of different concentrations of NRG1 was checked on the cultured melanocytes by melanin content assay, proliferation assay, and tyrosinase (TYR) assay. The effect of NRG1 was also checked on the level of melanocyte regulatory genes (MITF, c-KIT, TYR, DCT).Expression of NRG1 was significantly

2018 International Journal of Dermatology

148. Role of IL-17A receptor blocking in melanocytes survival: A strategic intervention against vitiligo. (PubMed)

Role of IL-17A receptor blocking in melanocytes survival: A strategic intervention against vitiligo. Cytokines regulate immune response and inflammation and play an important role in depigmentation process of an autoimmune disease, vitiligo. We sought to determine how inflammatory cytokines influence the progression of vitiligo, and based on that, we develop a logical therapeutic intervention using primary melanocyte culture. Melanocytes were cultured and exposed to IL-17A, IL-1β, IFN-γ and TGF

2018 Experimental Dermatology

149. Polymorphisms in melanocortin system and MYG1 genes are associated with vitiligo. (PubMed)

Polymorphisms in melanocortin system and MYG1 genes are associated with vitiligo. 30051642 2019 02 12 1468-3083 33 2 2019 Feb Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Polymorphisms in melanocortin system and MYG1 genes are associated with vitiligo. e65-e67 10.1111/jdv.15195 Traks T T Department of Dermatology and Venerology, University of Tartu, Tartu, Estonia. Keermann M M Department of Dermatology and Venerology, University of Tartu

2018 Journal of the European Academy of Dermatology and Venereology

150. Clinical Application of Cultured Stratified Epithelial Sheets Grown Under Feeder or Feeder-Free Conditions for Stable Vitiligo. (PubMed)

Clinical Application of Cultured Stratified Epithelial Sheets Grown Under Feeder or Feeder-Free Conditions for Stable Vitiligo. Autologous cultured therapy has emerged as an effective treatment for stable vitiligo. However, culture methods may include harmful agents and be unsuitable for therapeutic use in humans.To investigate the safety and efficacy of autologous cultured epithelial sheets propagated under serum-free and feeder-free conditions for the treatment of stable vitiligo.Twenty-eight (...) patients with stable vitiligo were included in this study. Keratinocytes and melanocytes from 14 patients were cultured under serum-free, feeder-free conditions (Group A). Epithelial cells from the remaining 14 patients were cultured according to Rheinward and Green's technique (Group B). Patients were followed up at 1, 3, 6, and 12 months after transplantation.The epithelial sheets cultured in Group A were thinner and more fragile than Group B, but there were no significant differences

2018 Dermatologic Surgery

151. What do Vitiligo Impact Scale (VIS)-22 scores mean? Studying the clinical interpretation of scores using an anchor-based approach. (PubMed)

What do Vitiligo Impact Scale (VIS)-22 scores mean? Studying the clinical interpretation of scores using an anchor-based approach. The Vitiligo Impact Scale (VIS)-22 is a vitiligo-specific quality-of-life instrument. Its criterion, convergent and known-groups validity, test-retest reliability and responsiveness have been studied previously in an Indian population. The clinical meaning of VIS-22 scores has not yet been analysed.To assign clinical meaning to VIS-22 scores using anchor-based (...) methods.This was a cross-sectional study conducted in a large teaching hospital in North India. Patients with vitiligo > 15 years of age (n = 391) completed the VIS-22 and Dermatology Life Quality Index (DLQI) questionnaires, and answered a Global Question (GQ) on the effect of vitiligo on their lives on a five-point Likert scale. Multiple band sets of VIS-22 scores were devised using GQ as the anchor. A weighted kappa-coefficient was calculated to estimate the level of agreement between different band

2018 British Journal of Dermatology

152. Ablative fractional Co<sub>2</sub> laser aided delivery of long-acting glucocorticoid in the treatment of acral vitiligo: A multicenter, prospective, self- bilateral controlled study. (PubMed)

Ablative fractional Co2 laser aided delivery of long-acting glucocorticoid in the treatment of acral vitiligo: A multicenter, prospective, self- bilateral controlled study. Acral vitiligo often responses poorly to treatments.To observe whether pretreatment with ablative fractional CO2 laser aiding penetration of compound betamethasone solution plus NB-UVB could improve the response of refractory acral vitiligo.Subjects with symmetrical and stable acral vitiligo were enrolled (...) eighty-nine subjects entered the clinical trial and 126 subjects completed the study. The experiment side showed better improvement in repigmentation. Overall response rate (repigmentation percentage ≥10%) of experiment sides was 51.6%, in contrast, that of control side was 35.8%. There were no severe adverse events in all subjects during the trial.A triple method of ablative fractional CO2 laser, topical compound betamethasone solution plus NB-UVB provided an alternative choice for acral vitiligo

2018 Journal of Dermatological Treatment

153. Vitamin D receptor gene polymorphism, serum 25-hydroxyvitamin D levels, and risk of vitiligo: A meta-analysis. (PubMed)

Vitamin D receptor gene polymorphism, serum 25-hydroxyvitamin D levels, and risk of vitiligo: A meta-analysis. To explore the relationship among the vitamin D receptor (VDR) gene polymorphisms, serum 25-hydroxyvitamin D levels, and vitiligo.Databases including PubMed, Cochrane Library, Ovid, Web of Science, CNKI, SinoMed, and Wanfang Data were systematically searched. The association was assessed using odds ratios (ORs), standard mean difference (SMD), and 95% confidence intervals (CIs (...) ). The statistical tests were performed using Review Manager 5.3.3.We identified a total of 17 studies. The relationship between VDR gene polymorphisms (BsmI, ApaI, TaqI, and FokI), serum 25 (OH)D levels, and incidence of vitiligo was investigated. The results of this meta-analysis showed that the dominant genetic model (CC+AC vs AA, P = .007, OR = 1.41, 95% CI = 1.10-1.80), recessive genetic model (CC vs AC+AA, P = .01, OR = 4.10, 95% CI = 1.36-12.35), and allelic contrast model (C vs A, P = .005, OR = 1.87, 95

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2018 Medicine

154. HSP70I<sub>Q435A</sub>-Encoding DNA Repigments Vitiligo Lesions in Sinclair Swine. (PubMed)

HSP70IQ435A-Encoding DNA Repigments Vitiligo Lesions in Sinclair Swine. Human HSP70iQ435A carries a single amino-acid modification within the dendritic cell activating region and tolerizes dendritic cells in vitro. The underlying DNA was used to prevent and treat disease in vitiligo mouse models through reduced dendritic cell activation and diminished skin T-cell infiltration, suggesting the same may be useful for patients. Physiologic differences between mouse and human skin (...) then called for studies in large animals with human-like skin. We established the efficiency of DNA jet injection into swine skin before subcloning HSP70iQ435A into clinically suitable vector pUMVC3. Vitiligo lesions in Sinclair swine were treated with plasmid DNA to measure changes in depigmentation, T-cell infiltration, expression of HSP70i in skin, serum HSP70i, and anti-HSP70i serum titers. Remarkable repigmentation following HSP70iQ435A-encoding DNA treatment persisted throughout the 6-month follow

2018 Journal of Investigative Dermatology

155. Disseminated Superficial Actinic Porokeratosis in a Vitiligo Patient Undergoing Treatment with Long-Term Narrowband Ultraviolet B (PubMed)

Disseminated Superficial Actinic Porokeratosis in a Vitiligo Patient Undergoing Treatment with Long-Term Narrowband Ultraviolet B 29606833 2018 11 14 1013-9087 30 2 2018 Apr Annals of dermatology Ann Dermatol Disseminated Superficial Actinic Porokeratosis in a Vitiligo Patient Undergoing Treatment with Long-Term Narrowband Ultraviolet B. 249-251 10.5021/ad.2018.30.2.249 Shin Eun-Jae EJ Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Korea. Gwak Min Jae MJ Department

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2018 Annals of dermatology

156. Investigation the Relationship between Skin Involvement Severity and Hearing Loss Severity in Vitiligo Patients (PubMed)

Investigation the Relationship between Skin Involvement Severity and Hearing Loss Severity in Vitiligo Patients Vitiligo is a common acquired depigmented systemic disorder influencing the entire pigmentary system including Cochlear melanocytes and vestibular system in the inner ear. Vitiligo can leads to social negative impact and poorer quality of life among these patients. This study was conducted to investigate the relationship between skin involvement severity and hearing loss severity (...) among vitiligo patients.This cross-sectional study was performed on 98 patients with vitiligo referred to the dermatology clinic of Shahid Beheshti Hospital of Kashan during 2012-2014. Using Vitiligo Area Severity Index (VASI), the skin involvement was evaluated by a dermatologist. Then, patients referred to an otolaryngologist, and after otoscopic examination, they underwent audiometric testing including Audiometry, Tympanometry and Auditory Brainstem Response (ABR tests. Patients aged 10-50 years

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2018 Materia socio-medica

157. Utility of dermoscopy for evaluating the therapeutic efficacy of tacrolimus ointment plus 308-nm excimer laser combination therapy in localized vitiligo patients (PubMed)

Utility of dermoscopy for evaluating the therapeutic efficacy of tacrolimus ointment plus 308-nm excimer laser combination therapy in localized vitiligo patients The aim of the present study was to assess the function of dermoscopy in evaluating the therapeutic efficacy of tacrolimus ointment plus 308-nm excimer laser combination therapy in patients with localized vitiligo. A total of 147 patients with localized vitiligo (progressive disease, n=92; stable period, n=55) were enrolled (...) and received combination therapy for 12 weeks. The condition of the skin lesions was monitored by dermoscopy and visual observation. At the initial visit, skin lesions were observed in 61 progressive and 19 stable patients. Residual perifollicular pigmentation was more abundant in progressive-stage patients than in stable-stage patients, whereas the presence of perilesional hyperpigmentation was obviously lower in patients with progressive vitiligo. After 12 weeks of combination therapy, marked differences

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2018 Experimental and therapeutic medicine

158. Treatment with Modified Heat Shock Protein Repigments Vitiligo Lesions in Sinclair Swine. (PubMed)

Treatment with Modified Heat Shock Protein Repigments Vitiligo Lesions in Sinclair Swine. HSP70i is secreted by stressed melanocytes, is associated with human vitiligo lesions, and functionally contributes to a mouse model of vitiligo. Henning et al. report that treatment with a modified version of the protein reversed depigmentation in Sinclair swine, a useful animal model of vitiligo. These studies provide the rationale for testing in human studies.Copyright © 2018 The Authors. Published

2018 Journal of Investigative Dermatology

159. Patient reported outcomes for intensified versus conventional NB-UVB treatment in non-segmental vitiligo. (PubMed)

Patient reported outcomes for intensified versus conventional NB-UVB treatment in non-segmental vitiligo. Treatment of non-segmental vitiligo (NSV) remains a challenge. Efficacy of NB-UVB treatment may increase with more frequent use or in combination with topical agents. Currently, data on the most effective treatment regimen lacking. Our objective is to retrospectively compare NB-UVB treatment regimens for non-segmental vitiligo.Patients with NSV treated with NB-UVB therapy were included

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2018 Journal of Dermatological Treatment

160. Comparison of microneedling and full surface erbium laser dermabrasion for autologous cell suspension grafting in non-segmental vitiligo: a randomized controlled trial. (PubMed)

Comparison of microneedling and full surface erbium laser dermabrasion for autologous cell suspension grafting in non-segmental vitiligo: a randomized controlled trial. 30488531 2019 02 14 1365-2133 2018 Nov 29 The British journal of dermatology Br. J. Dermatol. Comparison of microneedling and full surface erbium laser dermabrasion for autologous cell suspension grafting in nonsegmental vitiligo: a randomized controlled trial. 10.1111/bjd.17464 Lagrange S S Department of Dermatology, Centre

2018 British Journal of Dermatology

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