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Vitiligo

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141. Cutaneous expression of thymic stromal lymphopoietin (TSLP) in vitiligo patients: a case-control study. (Abstract)

Cutaneous expression of thymic stromal lymphopoietin (TSLP) in vitiligo patients: a case-control study. Thymic stromal lymphopoietin (TSLP) is a major pro-allergic cytokine promoting T helper-2 responses. Our aim was to study and verify the hypothesis of the role of TSLP in the pathogenesis of vitiligo.This case-control study was conducted on 25 patients with generalized non-segmental vitiligo (recruited from the Dermatology outpatient clinic, Kasr El Ainy, Faculty of Medicine, Cairo University (...) ) and 25 healthy controls fulfilling the inclusion criteria over a period of 7 months (January 2017-July 2017). Patients underwent complete medical history, detailed assessment of vitiligo, and photographic documentation. Skin biopsies were taken from the back from both patients' vitiliginous skin and from normal skin of controls for which relative TSLP messenger RNA (mRNA) tissue expression levels were measured using quantitative real-time polymerase chain reaction technique.There was a statistically

2018 International Journal of Dermatology

142. A Phase 2b Study To Evaluate The Efficacy And Safety Profile Of PF-06651600 And PF-06700841 In Active Non-segmental Vitiligo Subjects

A Phase 2b Study To Evaluate The Efficacy And Safety Profile Of PF-06651600 And PF-06700841 In Active Non-segmental Vitiligo Subjects A Phase 2b Study To Evaluate The Efficacy And Safety Profile Of PF-06651600 And PF-06700841 In Active Non-segmental Vitiligo Subjects - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You (...) have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Phase 2b Study To Evaluate The Efficacy And Safety Profile Of PF-06651600 And PF-06700841 In Active Non-segmental Vitiligo Subjects The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before

2018 Clinical Trials

143. Resident memory and recirculating memory T cells cooperate to maintain disease in a mouse model of vitiligo. Full Text available with Trip Pro

Resident memory and recirculating memory T cells cooperate to maintain disease in a mouse model of vitiligo. Tissue resident memory T cells (Trm) form in the skin in vitiligo and persist to maintain disease, as white spots often recur rapidly after discontinuing therapy. We and others have recently described melanocyte-specific autoreactive Trm in vitiligo lesions. Here, we characterize the functional relationship between Trm and recirculating memory T cells (Tcm) in our vitiligo mouse model (...) . We found that both Trm and Tcm sensed autoantigen in the skin long after stabilization of disease, producing IFN-γ, CXCL9, and CXCL10. Blockade of Tcm recruitment to the skin with FTY720 or depletion of Tcm with low-dose Thy1.1 antibody reversed disease, indicating that Trm cooperate with Tcm to maintain disease. Taken together, our data provide characterization of skin memory T cells in vitiligo, demonstrate that Trm and Tcm work together during disease, and indicate that targeting

2018 Journal of Investigative Dermatology

144. Vitiligo after alemtuzumab treatment: Secondary autoimmunity is not all about B cells. Full Text available with Trip Pro

Vitiligo after alemtuzumab treatment: Secondary autoimmunity is not all about B cells. To report 3 patients with relapsing-remitting multiple sclerosis (RRMS) showing vitiligo after treatment with alemtuzumab.Retrospective case series including flow cytometric analyses and T-cell receptor (TCR) sequencing of peripheral blood mononuclear cells.We describe 3 cases of alemtuzumab-treated patients with RRMS developing vitiligo 52, 18, and 14 months after alemtuzumab initiation. Histopathology shows (...) loss of epidermal pigmentation with absence of melanocytes and interface dermatitis with CD8+ T-cell infiltration. Also compatible with pathophysiologic concepts of vitiligo, peripheral blood mononuclear cells of one patient showed high proportions of CD8+ T cells with an activated (human leukocyte antigen-DR+), memory (CD45RO+), and type 1 cytokine (interferon-γ + tumor necrosis factor-α) phenotype at vitiligo onset compared to a control cohort of alemtuzumab-treated patients with RRMS (n = 30

2018 Neurology

145. Vitiligo surgery: a journey from tissues via cells to the stems! Full Text available with Trip Pro

Vitiligo surgery: a journey from tissues via cells to the stems! Depigmented patches in vitiligo, a common dermatosis, cause a great psychological distress to the patients. Hence, apart from halting the disease process, the strategies to impart normal skin colour to these white patches carry an important role in the management of vitiligo. Surgical procedures are often required for stable vitiligo lesions not responding to medical therapies. It involves "shuffling" of melanocytes from (...) the pigmented skin to the depigmented areas. During the last fifty years, the vitiligo surgery has evolved from tissue transplantation via cellular transplantation to reach a stage where the use of stem cells or immunomodulatory cells is contemplating. We would like to depict this wonderful journey of vitiligo surgery through this viewpoint.© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

2018 Experimental Dermatology

146. A case-control study on association of proteasome subunit beta 8 (PSMB8) and transporter associated with antigen processing 1 (TAP1) polymorphisms and their transcript levels in vitiligo from Gujarat. Full Text available with Trip Pro

A case-control study on association of proteasome subunit beta 8 (PSMB8) and transporter associated with antigen processing 1 (TAP1) polymorphisms and their transcript levels in vitiligo from Gujarat. Autoimmunity has been implicated in the destruction of melanocytes from vitiligo skin. Major histocompatibility complex (MHC) class-II linked genes proteasome subunit beta 8 (PSMB8) and transporter associated with antigen processing 1 (TAP1), involved in antigen processing and presentation have (...) been reported to be associated with several autoimmune diseases including vitiligo.To explore PSMB8 rs2071464 and TAP1 rs1135216 single nucleotide polymorphisms and to estimate the expression of PSMB8 and TAP1 in patients with vitiligo and unaffected controls from Gujarat.PSMB8 rs2071464 polymorphism was genotyped using polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) and TAP1 rs1135216 polymorphism was genotyped by amplification refractory mutation system-polymerase

2017 PLoS ONE

147. Use of platelet-rich plasma to suspend noncultured epidermal cell suspension improves repigmentation after autologous transplantation in stable vitiligo: a double-blind randomized controlled trial. (Abstract)

Use of platelet-rich plasma to suspend noncultured epidermal cell suspension improves repigmentation after autologous transplantation in stable vitiligo: a double-blind randomized controlled trial. Noncultured epidermal cell suspension (NCES) is an effective surgical modality for stable vitiligo which involves transplantation of the basal layer of epidermal cells onto the dermabraded vitiliginous patch. Platelet-rich plasma (PRP) has growth factors which may stimulate melanocyte migration (...) and proliferation of keratinocytes and fibroblasts. The objective of this study was to compare the extent of repigmentation achieved by transplantation of NCES suspended in PRP with that of NCES suspended in phosphate buffered saline (PBS).Twenty-one patients of stable vitiligo with at least two lesions of comparable size were included. The two vitiligo patches were randomized to receive NCES suspended in PRP or PBS. Postoperatively after 1 week, patients were given heliotherapy for 15 minutes daily.At 6 months

2018 International Journal of Dermatology Controlled trial quality: uncertain

148. Treatment with Modified Heat Shock Protein Repigments Vitiligo Lesions in Sinclair Swine. Full Text available with Trip Pro

Treatment with Modified Heat Shock Protein Repigments Vitiligo Lesions in Sinclair Swine. HSP70i is secreted by stressed melanocytes, is associated with human vitiligo lesions, and functionally contributes to a mouse model of vitiligo. Henning et al. report that treatment with a modified version of the protein reversed depigmentation in Sinclair swine, a useful animal model of vitiligo. These studies provide the rationale for testing in human studies.Copyright © 2018 The Authors. Published

2018 Journal of Investigative Dermatology

149. Comparison of microneedling and full surface erbium laser dermabrasion for autologous cell suspension grafting in non-segmental vitiligo: a randomized controlled trial. (Abstract)

Comparison of microneedling and full surface erbium laser dermabrasion for autologous cell suspension grafting in non-segmental vitiligo: a randomized controlled trial. 30488531 2019 02 14 1365-2133 2018 Nov 29 The British journal of dermatology Br. J. Dermatol. Comparison of microneedling and full surface erbium laser dermabrasion for autologous cell suspension grafting in nonsegmental vitiligo: a randomized controlled trial. 10.1111/bjd.17464 Lagrange S S Department of Dermatology, Centre

2018 British Journal of Dermatology Controlled trial quality: uncertain

150. Patient reported outcomes for intensified versus conventional NB-UVB treatment in non-segmental vitiligo. Full Text available with Trip Pro

Patient reported outcomes for intensified versus conventional NB-UVB treatment in non-segmental vitiligo. Treatment of non-segmental vitiligo (NSV) remains a challenge. Efficacy of NB-UVB treatment may increase with more frequent use or in combination with topical agents. Currently, data on the most effective treatment regimen lacking. Our objective is to retrospectively compare NB-UVB treatment regimens for non-segmental vitiligo.Patients with NSV treated with NB-UVB therapy were included

2018 Journal of Dermatological Treatment

151. Bimatoprost 0.03% Solution With NB-UVB Versus Their Use With Fractional Carbon Dioxide Laser in Treatment of Generalized Vitiligo

Bimatoprost 0.03% Solution With NB-UVB Versus Their Use With Fractional Carbon Dioxide Laser in Treatment of Generalized Vitiligo Bimatoprost 0.03% Solution With NB-UVB Versus Their Use With Fractional Carbon Dioxide Laser in Treatment of Generalized Vitiligo - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have (...) reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Bimatoprost 0.03% Solution With NB-UVB Versus Their Use With Fractional Carbon Dioxide Laser in Treatment of Generalized Vitiligo The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before

2018 Clinical Trials

152. Comparative Study of Surgical Treatment of Vitiligo

Comparative Study of Surgical Treatment of Vitiligo Comparative Study of Surgical Treatment of Vitiligo - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Comparative Study of Surgical Treatment of Vitiligo (...) by (Responsible Party): Hospital de Clinicas de Porto Alegre Study Details Study Description Go to Brief Summary: A comparative study for the surgical treatment of vitiligo in which the same patient will receive in acromic and symmetric lesions of vitiligo dermabrasion with micro needling and on the other side dermabrasion with micro needling followed by the application of cell suspension (melanocytes and uncultured keratinocytes). These cells will be removed from the own patient through the skin of the scalp

2018 Clinical Trials

153. The Gut and Skin Microbiome in Vitiligo Disease Progression

The Gut and Skin Microbiome in Vitiligo Disease Progression The Gut and Skin Microbiome in Vitiligo Disease Progression - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Gut and Skin Microbiome (...) in Vitiligo Disease Progression The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03577327 Recruitment Status : Not yet recruiting First Posted : July 4, 2018 Last Update Posted : July 4, 2018 See Sponsor: Northwestern University

2018 Clinical Trials

154. Metabolic Syndrome in Early Onset Versus Late Onset Vitiligo

Metabolic Syndrome in Early Onset Versus Late Onset Vitiligo Metabolic Syndrome in Early Onset Versus Late Onset Vitiligo - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Metabolic Syndrome in Early Onset (...) Versus Late Onset Vitiligo The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03622320 Recruitment Status : Recruiting First Posted : August 9, 2018 Last Update Posted : August 9, 2018 See Sponsor: Cairo University

2018 Clinical Trials

155. Efficiency of Fractional-Laser Resurfacing Followed by Topical Tacrolimus 0.03% Cream vs Tacrolimus Alone in Vitiligo

Efficiency of Fractional-Laser Resurfacing Followed by Topical Tacrolimus 0.03% Cream vs Tacrolimus Alone in Vitiligo Efficiency of Fractional-Laser Resurfacing Followed by Topical Tacrolimus 0.03% Cream vs Tacrolimus Alone in Vitiligo - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Efficiency of Fractional-Laser Resurfacing Followed by Topical Tacrolimus 0.03% Cream vs Tacrolimus Alone in Vitiligo The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03535051 Recruitment Status : Completed First Posted : May

2018 Clinical Trials

156. Effects of Camouflage on the Life Quality of Patients With Vitiligo

Effects of Camouflage on the Life Quality of Patients With Vitiligo Effects of Camouflage on the Life Quality of Patients With Vitiligo - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effects of Camouflage (...) on the Life Quality of Patients With Vitiligo The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03540966 Recruitment Status : Recruiting First Posted : May 30, 2018 Last Update Posted : May 30, 2018 See Sponsor: Xijing Hospital

2018 Clinical Trials

157. Microneedling and Latanoprost in Acrofacial Vitiligo

Microneedling and Latanoprost in Acrofacial Vitiligo Microneedling and Latanoprost in Acrofacial Vitiligo - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Microneedling and Latanoprost in Acrofacial Vitiligo (...) by (Responsible Party): Noreen Ismail AbdelGhani Ahmed, Sohag University Study Details Study Description Go to Brief Summary: To compare efficacy of topical latanoprost preceded by microneedling versus topical latanoprost alone in treatment of acrofacial vitiligo. Condition or disease Intervention/treatment Phase Vitiligo Drug: Latanoprost Device: Microneedling Phase 2 Phase 3 Detailed Description: patients meeting inclusion and exclusion criteria presented to Dermatology Outpatient Clinic, Sohag University

2018 Clinical Trials

158. Efficacy and Safety of Total Glucosides of Paeony Combined With NB-UVB on Treating Vitiligo

Efficacy and Safety of Total Glucosides of Paeony Combined With NB-UVB on Treating Vitiligo Efficacy and Safety of Total Glucosides of Paeony Combined With NB-UVB on Treating Vitiligo - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Efficacy and Safety of Total Glucosides of Paeony Combined With NB-UVB on Treating Vitiligo The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03608917 Recruitment Status : Enrolling by invitation First Posted : August 1, 2018 Last Update Posted : August 1, 2018 Sponsor: xjpfW

2018 Clinical Trials

159. Disseminated Superficial Actinic Porokeratosis in a Vitiligo Patient Undergoing Treatment with Long-Term Narrowband Ultraviolet B Full Text available with Trip Pro

Disseminated Superficial Actinic Porokeratosis in a Vitiligo Patient Undergoing Treatment with Long-Term Narrowband Ultraviolet B 29606833 2018 11 14 1013-9087 30 2 2018 Apr Annals of dermatology Ann Dermatol Disseminated Superficial Actinic Porokeratosis in a Vitiligo Patient Undergoing Treatment with Long-Term Narrowband Ultraviolet B. 249-251 10.5021/ad.2018.30.2.249 Shin Eun-Jae EJ Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Korea. Gwak Min Jae MJ Department

2018 Annals of dermatology

160. Vitiligo immune reconstitution inflammatory syndrome (IRIS)—An incidental finding in a tertiary teaching hospital in southeast Nigeria Full Text available with Trip Pro

Vitiligo immune reconstitution inflammatory syndrome (IRIS)—An incidental finding in a tertiary teaching hospital in southeast Nigeria 29387768 2019 02 26 2352-5126 4 2 2018 Mar JAAD case reports JAAD Case Rep Vitiligo immune reconstitution inflammatory syndrome (IRIS)-An incidental finding in a tertiary teaching hospital in southeast Nigeria. 145-148 10.1016/j.jdcr.2017.09.030 Onyekonwu Chinwe Laura CL Sub-Department of Dermatology, College of Medicine, University of Nigeria, Ituku-Ozalla (...) HIV IRIS, immune reconstitution inflammatory syndrome highly active antiretroviral therapy immune reconstitution inflammatory syndrome vitiligo 2018 2 2 6 0 2018 2 2 6 0 2018 2 2 6 1 epublish 29387768 10.1016/j.jdcr.2017.09.030 S2352-5126(17)30239-4 PMC5789520 Curr Opin HIV AIDS. 2010 Nov;5(6):504-10 20966640 J Acquir Immune Defic Syndr. 1989;2(4):382-8 2666640 Indian J Dermatol. 2014 Mar;59(2):209 24700956 Arch Dermatol. 1991 Sep;127(9):1383-91 1892408 Int J STD AIDS. 2007 Feb;18(2):138-9

2018 JAAD Case Reports

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