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Vitiligo

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121. The early repigmentation pattern of vitiligo is related to the source of melanocytes and by the choice of therapy: a retrospective cohort study. (Abstract)

The early repigmentation pattern of vitiligo is related to the source of melanocytes and by the choice of therapy: a retrospective cohort study. Patients with vitiligo present with different repigmentation patterns in the early recovery stage.To analyze the relationships between early repigmentation patterns in vitiliginous patches, their clinical characteristics, and therapeutic choices.Patients with vitiligo seen in the Department of Dermatology, The First Affiliated Hospital of Nanjing (...) ), progressive stage (P = 0.044), and truncal lesions treated with TVDAs (P < 0.001).The different repigmentation patterns of vitiligo lesions depend on the different source and status of melanocytes and their abilities to produce melanin on the choice of therapy.© 2018 The International Society of Dermatology.

2018 International Journal of Dermatology

122. Efficacy and safety of noncultured melanocyte-keratinocyte transplant procedure for vitiligo and other leukodermas: a critical analysis of the evidence. (Abstract)

Efficacy and safety of noncultured melanocyte-keratinocyte transplant procedure for vitiligo and other leukodermas: a critical analysis of the evidence. Vitiligo is an acquired pigmentary skin of depigmentation occurring secondary to melanocyte destruction. Vitiligo and other leukodermas have a profound impact on quality of life. Current therapies include medical options, such as phototherapy, topical and systemic corticosteroids, topical calcineurin inhibitors, immunomodulators (...) , and antioxidiants, and surgical options. Surgical options provide melanocytic cells to previously depigmented areas and use either tissue grafting or cellular grafting methods. Topical treatments are often insufficient, and many of the current surgical procedures have shown variable response rates. In this review, we discuss the process of the cellular grafting melanocyte-keratinocyte transplantation procedure (MKTP) and critically analyze its efficacy and safety in the treatment of vitiligo and other

2018 International Journal of Dermatology

123. Ablative fractional Co<sub>2</sub> laser aided delivery of long-acting glucocorticoid in the treatment of acral vitiligo: A multicenter, prospective, self- bilateral controlled study. (Abstract)

Ablative fractional Co2 laser aided delivery of long-acting glucocorticoid in the treatment of acral vitiligo: A multicenter, prospective, self- bilateral controlled study. Acral vitiligo often responses poorly to treatments.To observe whether pretreatment with ablative fractional CO2 laser aiding penetration of compound betamethasone solution plus NB-UVB could improve the response of refractory acral vitiligo.Subjects with symmetrical and stable acral vitiligo were enrolled (...) eighty-nine subjects entered the clinical trial and 126 subjects completed the study. The experiment side showed better improvement in repigmentation. Overall response rate (repigmentation percentage ≥10%) of experiment sides was 51.6%, in contrast, that of control side was 35.8%. There were no severe adverse events in all subjects during the trial.A triple method of ablative fractional CO2 laser, topical compound betamethasone solution plus NB-UVB provided an alternative choice for acral vitiligo

2018 Journal of Dermatological Treatment Controlled trial quality: uncertain

124. What do Vitiligo Impact Scale (VIS)-22 scores mean? Studying the clinical interpretation of scores using an anchor-based approach. (Abstract)

What do Vitiligo Impact Scale (VIS)-22 scores mean? Studying the clinical interpretation of scores using an anchor-based approach. The Vitiligo Impact Scale (VIS)-22 is a vitiligo-specific quality-of-life instrument. Its criterion, convergent and known-groups validity, test-retest reliability and responsiveness have been studied previously in an Indian population. The clinical meaning of VIS-22 scores has not yet been analysed.To assign clinical meaning to VIS-22 scores using anchor-based (...) methods.This was a cross-sectional study conducted in a large teaching hospital in North India. Patients with vitiligo > 15 years of age (n = 391) completed the VIS-22 and Dermatology Life Quality Index (DLQI) questionnaires, and answered a Global Question (GQ) on the effect of vitiligo on their lives on a five-point Likert scale. Multiple band sets of VIS-22 scores were devised using GQ as the anchor. A weighted kappa-coefficient was calculated to estimate the level of agreement between different band

2018 British Journal of Dermatology

125. Clinical Application of Cultured Stratified Epithelial Sheets Grown Under Feeder or Feeder-Free Conditions for Stable Vitiligo. (Abstract)

Clinical Application of Cultured Stratified Epithelial Sheets Grown Under Feeder or Feeder-Free Conditions for Stable Vitiligo. Autologous cultured therapy has emerged as an effective treatment for stable vitiligo. However, culture methods may include harmful agents and be unsuitable for therapeutic use in humans.To investigate the safety and efficacy of autologous cultured epithelial sheets propagated under serum-free and feeder-free conditions for the treatment of stable vitiligo.Twenty-eight (...) patients with stable vitiligo were included in this study. Keratinocytes and melanocytes from 14 patients were cultured under serum-free, feeder-free conditions (Group A). Epithelial cells from the remaining 14 patients were cultured according to Rheinward and Green's technique (Group B). Patients were followed up at 1, 3, 6, and 12 months after transplantation.The epithelial sheets cultured in Group A were thinner and more fragile than Group B, but there were no significant differences

2018 Dermatologic Surgery

126. Polymorphisms in melanocortin system and MYG1 genes are associated with vitiligo. (Abstract)

Polymorphisms in melanocortin system and MYG1 genes are associated with vitiligo. 30051642 2019 02 12 1468-3083 33 2 2019 Feb Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Polymorphisms in melanocortin system and MYG1 genes are associated with vitiligo. e65-e67 10.1111/jdv.15195 Traks T T Department of Dermatology and Venerology, University of Tartu, Tartu, Estonia. Keermann M M Department of Dermatology and Venerology, University of Tartu

2018 Journal of the European Academy of Dermatology and Venereology

127. Comorbidities in vitiligo: comprehensive review. (Abstract)

Comorbidities in vitiligo: comprehensive review. Vitiligo is a common skin disorder characterized by idiopathic, progressive cutaneous hypomelanosis. Vitiligo is associated with several comorbid autoimmune, systemic, and dermatological diseases, primarily thyroid disease, alopecia areata, diabetes mellitus, pernicious anemia, systemic lupus erythematosus, rheumatoid arthritis, Addison's disease, inflammatory bowel disease, Sjögren's syndrome, dermatomyositis, scleroderma, ocular (...) and audiological abnormalities, psoriasis, and atopic dermatitis. It is essential to increase awareness of these comorbidities in order to improve the disease burden and quality of life of patients with vitiligo. Herein, we review the association with the most frequent comorbidities associated with vitiligo.© 2018 The International Society of Dermatology.

2018 International Journal of Dermatology

128. Decreased choroidal thickness in vitiligo patients. Full Text available with Trip Pro

Decreased choroidal thickness in vitiligo patients. Vitiligo is a disease characterized by depigmented macules and patches that occur as a result of the loss of functional melanocytes from the affected skin through a mechanism which has not been elucidated yet. Destruction of pigment cells in vitiligo may not remain limited to the skin; the eyelashes, iris, ciliary body, choroid, retinal pigment epithelium and meninges may also be affected. This study aims to compare the choroidal thickness (...) of patients with and without vitiligo using optical coherence tomography (OCT).Spectral-domain optical coherence tomography (SD-OCT) (Retina Scan Advanced RS-3000 NIDEK, Japan) instrument (with λ = 840 nm, 27,000 A-scans/second and 5 μm axial resolution) was used for the imaging. Statistical analysis was performed using SPSS 21.0 software package.In all values except optic nevre area measurements, the choroidal thickness of all vitiligo patients was found out to be thinner compared to the control group.In

2018 BMC Ophthalmology

129. Decreased expression of neuregulin1 in the lesional skin of vitiligo patients. (Abstract)

Decreased expression of neuregulin1 in the lesional skin of vitiligo patients. Paracrine cross-talk exists between the fibroblasts of dermis and epidermal cells through secretions of various growth factors. Melanocytes present at the basement layer of the epidermis and respond to various factors secreted by underlying dermal fibroblasts in the dermis to regulate the function of the skin.Therefore the study was planned to check the expression of fibroblast-derived factor neuregulin1 (NRG1 (...) ) in vitiligo skin and its effect on melanocytes.For this study, relative gene expression at mRNA level of NRG1 in the vitiligo skin was analyzed by qRT-PCR, and protein analysis was done by immunohistochemistry. Effect of different concentrations of NRG1 was checked on the cultured melanocytes by melanin content assay, proliferation assay, and tyrosinase (TYR) assay. The effect of NRG1 was also checked on the level of melanocyte regulatory genes (MITF, c-KIT, TYR, DCT).Expression of NRG1 was significantly

2018 International Journal of Dermatology

130. HSP70I<sub>Q435A</sub>-Encoding DNA Repigments Vitiligo Lesions in Sinclair Swine. Full Text available with Trip Pro

HSP70IQ435A-Encoding DNA Repigments Vitiligo Lesions in Sinclair Swine. Human HSP70iQ435A carries a single amino-acid modification within the dendritic cell activating region and tolerizes dendritic cells in vitro. The underlying DNA was used to prevent and treat disease in vitiligo mouse models through reduced dendritic cell activation and diminished skin T-cell infiltration, suggesting the same may be useful for patients. Physiologic differences between mouse and human skin (...) then called for studies in large animals with human-like skin. We established the efficiency of DNA jet injection into swine skin before subcloning HSP70iQ435A into clinically suitable vector pUMVC3. Vitiligo lesions in Sinclair swine were treated with plasmid DNA to measure changes in depigmentation, T-cell infiltration, expression of HSP70i in skin, serum HSP70i, and anti-HSP70i serum titers. Remarkable repigmentation following HSP70iQ435A-encoding DNA treatment persisted throughout the 6-month follow

2018 Journal of Investigative Dermatology

131. Tissue Expression of Aquaporine 3 in Different Sites of Vitiligo: An immunohistochemical study. (Abstract)

Tissue Expression of Aquaporine 3 in Different Sites of Vitiligo: An immunohistochemical study. 29729115 2018 11 29 1468-3083 32 12 2018 Dec Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Tissue expression of aquaporin 3 in different sites of vitiligo: an immunohistochemical study. e455-e456 10.1111/jdv.15049 Esmat S S Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt. Zeid O A OA Department of Dermatology

2018 Journal of the European Academy of Dermatology and Venereology

132. Elevated total Serum IgE in vitiligo might be protective for other autoimmune diseases. (Abstract)

Elevated total Serum IgE in vitiligo might be protective for other autoimmune diseases. 29704453 2018 10 15 1365-2133 179 4 2018 Oct The British journal of dermatology Br. J. Dermatol. Elevated total serum IgE in vitiligo might be protective for other autoimmune diseases. 987-988 10.1111/bjd.16707 Marti A A Department of Dermatology, Bordeaux University Hospitals, Bordeaux, France. Taieb A A Department of Dermatology, Bordeaux University Hospitals, Bordeaux, France. INSERM U 1035, University

2018 British Journal of Dermatology

133. The convergence theory for vitiligo: A reappraisal. Full Text available with Trip Pro

The convergence theory for vitiligo: A reappraisal. Vitiligo is characterized by progressive loss of skin pigmentation. The search for aetiologic factors has led to the biochemical, the neurologic and the autoimmune theory. The convergence theory was then proposed several years ago to incorporate existing theories of vitiligo development into a single overview of vitiligo aetiology. The viewpoint that vitiligo is not caused only by predisposing mutations, or only by melanocytes responding (...) to chemical/radiation exposure, or only by hyperreactive T cells, but rather results from a combination of aetiologic factors that impact melanocyte viability, has certainly stood the test of time. New findings have since informed the description of progressive depigmentation. Understanding the relative importance of such aetiologic factors combined with a careful selection of the most targetable pathways will continue to drive the next phase in vitiligo research: the development of effective therapeutics

2018 Experimental Dermatology

134. A prospective right-left comparative study to evaluate the efficacy and tolerability of combination of NB-UVB and topical bimatoprost 0.03% eye drops versus NB-UVB given alone in patients of vitiligo vulgaris. (Abstract)

A prospective right-left comparative study to evaluate the efficacy and tolerability of combination of NB-UVB and topical bimatoprost 0.03% eye drops versus NB-UVB given alone in patients of vitiligo vulgaris. 29444382 2018 03 09 1468-3083 2018 Feb 14 Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol A prospective right-left comparative study to evaluate the efficacy and tolerability of combination of NB-UVB and topical bimatoprost 0.03% eye (...) drops versus NB-UVB given alone in patients of vitiligo vulgaris. 10.1111/jdv.14882 Sharma S S Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Parsad D D Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Bhattacharjee R R Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research

2018 Journal of the European Academy of Dermatology and Venereology

135. Once weekly targeted excimer light produced modest re-pigmentation of vitiligo over a 20-week period. (Abstract)

Once weekly targeted excimer light produced modest re-pigmentation of vitiligo over a 20-week period. 29419905 2018 03 05 1468-3083 2018 Feb 08 Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Once weekly targeted excimer light produced modest repigmentation of vitiligo over a 20-week period. 10.1111/jdv.14853 Ayob S S Department of Dermatology, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK. Cockayne S E SE Department of Dermatology, Royal

2018 Journal of the European Academy of Dermatology and Venereology

136. Association of elevated homocysteine levels and Methylenetetrahydrofolate reductase (MTHFR) 1298 A &gt; C polymorphism with Vitiligo susceptibility in Gujarat. Full Text available with Trip Pro

Association of elevated homocysteine levels and Methylenetetrahydrofolate reductase (MTHFR) 1298 A > C polymorphism with Vitiligo susceptibility in Gujarat. Several studies have reported hyperhomocysteinemia in vitiligo patients, suggesting the potential role of elevated homocysteine levels in precipitating vitiligo.We aimed to estimate homocysteine and vitamin B12 levels, and to investigate the role of MTHFR 677 C > T and 1298 A > C polymorphisms in vitiligo susceptibility in Gujarat (...) population.Homocysteine and vitamin B12 levels were estimated in plasma of 55 vitiligo patients and 60 controls by Electrochemiluminescence immunoassay (ECLIA). Polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) and amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) techniques were used to genotype MTHFR 677 C > T and 1298 A > C polymorphisms in 520 vitiligo patients and 558 controls.Our results showed significantly elevated homocysteine levels (p = 0.0003

2018 Journal of dermatological science

137. Combination of Follicular and Epidermal Cell Suspension as a Novel Surgical Approach in Difficult-to-Treat Vitiligo: A Randomized Clinical Trial. Full Text available with Trip Pro

Combination of Follicular and Epidermal Cell Suspension as a Novel Surgical Approach in Difficult-to-Treat Vitiligo: A Randomized Clinical Trial. Epidermal cell suspension (ECS) and follicular cell suspension (FCS) are successful surgical modalities for the treatment of stable vitiligo. However, repigmentation in generalized and acrofacial vitiligo and over acral or bony sites (eg, elbows, knees, iliac crests, and malleoli), which are difficult to treat, is challenging.To study the efficacy (...) of transplanting a combination of autologous, noncultured ECS and FCS (ECS + FCS) compared with ECS alone in stable vitiligo.A prospective, observer-blinded, active-controlled, randomized clinical trial was conducted at a tertiary care hospital, with treatment administered as an outpatient procedure. Thirty participants who had stable vitiligo with symmetrical lesions were recruited between October 18, 2013, and October 28, 2016. All of the lesions were resistant to medical modalities with minimum lesional

2018 JAMA dermatology (Chicago, Ill.) Controlled trial quality: uncertain

138. Predictive Model for Response Rate to Narrowband Ultraviolet B Phototherapy in Vitiligo: A Retrospective Cohort Study of 579 Patients. Full Text available with Trip Pro

Predictive Model for Response Rate to Narrowband Ultraviolet B Phototherapy in Vitiligo: A Retrospective Cohort Study of 579 Patients. Vitiligo is an acquired depigmenting disorder. To date, there is no predictive model for its response rate to narrowband ultraviolet B (NBUVB) phototherapy. The aim of this study was to investigate the different types of response of patients with non-segmental vitiligo undergoing NBUVB 3 times a week. Many patients who were previously considered non-responders

2018 Acta Dermato-Venereologica

139. Leucotrichia in Vitiligo

Leucotrichia in Vitiligo Leucotrichia in Vitiligo - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Leucotrichia in Vitiligo The safety and scientific validity of this study is the responsibility of the study (...) to 48.4% of all vitiligo patients.Leucotrichia is more often observed in segmental vitiligo with a very high percentage. However, further studies considering the prevalence of leucotrichia in different types of vitiligo need to be conducted. Condition or disease Intervention/treatment Leucotrichia Other: Examination of leukotrichia in vitiligo patients Study Design Go to Layout table for study information Study Type : Observational Actual Enrollment : 107 participants Observational Model: Case-Only

2018 Clinical Trials

140. The Investigation on the Expression of High Mobility Group Protein Box-1 (HMGB1) in Peripheral Blood of Vitiligo Patients and Healthy Controls According to Clinical Features, Treatment and Disease Activity

The Investigation on the Expression of High Mobility Group Protein Box-1 (HMGB1) in Peripheral Blood of Vitiligo Patients and Healthy Controls According to Clinical Features, Treatment and Disease Activity The Investigation on the Expression of High Mobility Group Protein Box-1 (HMGB1) in Peripheral Blood of Vitiligo Patients and Healthy Controls According to Clinical Features, Treatment and Disease Activity - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers (...) : refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Investigation on the Expression of High Mobility Group Protein Box-1 (HMGB1) in Peripheral Blood of Vitiligo Patients and Healthy Controls According to Clinical Features, Treatment and Disease Activity The safety and scientific validity

2018 Clinical Trials

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