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Vitiligo

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101. Unconventional Treatments for Vitiligo: Are They (Un) Satisfactory? (Full text)

Unconventional Treatments for Vitiligo: Are They (Un) Satisfactory? The authors show a brief overview of the vitiligo's unconventional therapies. A part for well-documented effectiveness of L-phenylalanine, PGE2 and antioxidant agents in the treatment of vitiligo, for the other therapeutical approaches more investigations are needed.

2018 Open access Macedonian journal of medical sciences

102. Comparing Recipient Site Preparation Using Dermabrasion, Dermaroller and Liquid Nitrogen Induced Blister in Non Cultured Epidermal Cell Suspension in Stable Vitiligo

Comparing Recipient Site Preparation Using Dermabrasion, Dermaroller and Liquid Nitrogen Induced Blister in Non Cultured Epidermal Cell Suspension in Stable Vitiligo Comparing Recipient Site Preparation Using Dermabrasion, Dermaroller and Liquid Nitrogen Induced Blister in Non Cultured Epidermal Cell Suspension in Stable Vitiligo - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x (...) × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Comparing Recipient Site Preparation Using Dermabrasion, Dermaroller and Liquid Nitrogen Induced Blister in Non Cultured Epidermal Cell Suspension in Stable Vitiligo The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated

2018 Clinical Trials

103. The Effect of UVB Phototherapy With Microneedling and Circled Needing in Vitiligo Patients

The Effect of UVB Phototherapy With Microneedling and Circled Needing in Vitiligo Patients The Effect of UVB Phototherapy With Microneedling and Circled Needing in Vitiligo Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. The Effect of UVB Phototherapy With Microneedling and Circled Needing in Vitiligo Patients The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03718962 Recruitment Status : Recruiting First Posted

2018 Clinical Trials

104. A Phase 2b Study To Evaluate The Efficacy And Safety Profile Of PF-06651600 And PF-06700841 In Active Non-segmental Vitiligo Subjects

A Phase 2b Study To Evaluate The Efficacy And Safety Profile Of PF-06651600 And PF-06700841 In Active Non-segmental Vitiligo Subjects A Phase 2b Study To Evaluate The Efficacy And Safety Profile Of PF-06651600 And PF-06700841 In Active Non-segmental Vitiligo Subjects - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You (...) have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Phase 2b Study To Evaluate The Efficacy And Safety Profile Of PF-06651600 And PF-06700841 In Active Non-segmental Vitiligo Subjects The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before

2018 Clinical Trials

105. Comparison of Surgical Methods on Resistant Sites in Stable Vitiligo Patients

Comparison of Surgical Methods on Resistant Sites in Stable Vitiligo Patients Comparison of Surgical Methods on Resistant Sites in Stable Vitiligo Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Comparison of Surgical Methods on Resistant Sites in Stable Vitiligo Patients The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03717025 Recruitment Status : Recruiting First Posted : October 23, 2018 Last Update Posted

2018 Clinical Trials

106. Identification of the Risk HLA-A Alleles and Autoantigen in Han Chinese Vitiligo Patients and the Association of CD8+T Cell Reactivity with Disease Characteristics (Full text)

Identification of the Risk HLA-A Alleles and Autoantigen in Han Chinese Vitiligo Patients and the Association of CD8+T Cell Reactivity with Disease Characteristics BACKGROUND Multiple studies have implicated a role for CD8+T cell-mediated immune response to autoantigens in vitiligo. However, the antigen-specific T lymphocyte reactivity against the peptide epitopes is diverse among different world populations. This study aimed to identify the risk HLA-A allele in vitiligo and study CD8+ T cell (...) reactivity to 5 autoantigenic peptides in Han Chinese populations, and to analyze the association of CD8+ T cell reactivity with disease characteristics. MATERIAL AND METHODS The risk HLA-A allele was analyzed by case-control study. Enzyme linked immunospot (ELISPOT) assay was used to compare T cell reactivity to the 5 autoantigenic peptides between vitiligo patients and healthy controls, then we analyzed the association of CD8+ T cell reactivity to 2 positive peptides with disease activity and area

2018 Medical science monitor : international medical journal of experimental and clinical research

107. Potential anti-vitiligo properties of cynarine extracted from Vernonia anthelmintica (L.) Willd (Full text)

Potential anti-vitiligo properties of cynarine extracted from Vernonia anthelmintica (L.) Willd Vitiligo is a depigmentation disorder of the skin. It is primarily caused by the destruction of melanocytes or obstruction of the melanin synthesis pathway. Melanin is a type of skin pigment that determines skin color. The seeds of Vernonia anthelmintica (L.) Willd (Kaliziri) are used for treating skin diseases including vitiligo in traditional Uyghur medicine. 1,5‑Dicaffeoylquinic acid (1,5‑diCQA (...) induced by 1,5‑diCQA treatment were significantly attenuated by the protein kinase A (PKA) inhibitor H‑89. Intracellular cyclic adenosine monophosphate (cAMP) concentration and phosphorylation of cAMP‑response element binding protein was increased following 1,5‑diCQA treatment. These results indicated that 1,5‑diCQA stimulated melanogenesis via the MAPK and cAMP/PKA signaling pathways in B16 cells, which has potential therapeutic implications for vitiligo.

2018 International journal of molecular medicine

108. Porphyria Cutanea Tarda Presenting with Scleroderma, Ichthyosis, Alopecia, and Vitiligo (Full text)

Porphyria Cutanea Tarda Presenting with Scleroderma, Ichthyosis, Alopecia, and Vitiligo Porphyria cutanea tarda (PCT) is a cutaneous porphyria that presents later in life with cutaneous findings in sun-exposed sites. We report a complex case of PCT in a 67-year-old woman with an unusual constellation of cutaneous findings: scleroderma, acquired ichthyosis, and nonscarring alopecia. Possible triggers for her PCT include tamoxifen treatment for breast cancer and carrier status (...) of the hemochromatosis gene. High-dose chloroquine was used to successfully achieve clinical remission and normalize her uroporphyrins. While on chloroquine she developed extensive classic vitiligo. It is not clear if this is another feature of her complex and unusual PCT, or a consequence of her antimalarial therapy.

2018 Case reports in dermatology

109. Clinical and Molecular Aspects of Vitiligo Treatments (Full text)

Clinical and Molecular Aspects of Vitiligo Treatments Vitiligo is an asymptomatic but cosmetically disfiguring disorder that results in the formation of depigmented patches on skin and/or mucosae. Vitiligo can be segmental or non-segmental depending upon the morphology of the clinical involvement. It can also be classified as progressing or stable based on the activity of the disease. Further, the extent of involvement can be limited (localized disease) or extensive (generalized disease (...) ). The treatment of vitiligo therefore depends on the clinical classification/characteristics of the disease and usually comprises of 2 strategies. The first involves arresting the progression of active disease (to provide stability) in order to limit the area involved by depigmentation. The second strategy aims at repigmentation of the depigmented area. It is also important to maintain the disease in a stable phase and to prevent relapse. Accordingly, a holistic treatment approach for vitiligo should

2018 International journal of molecular sciences

110. Association rare: lichen scléroatrophique extragénital et vitiligo inflammatoire chez un enfant (Full text)

Association rare: lichen scléroatrophique extragénital et vitiligo inflammatoire chez un enfant Scleroatrophic lichen (SL) and vitiligo are two depigmenting disorders which may occur separately or, rarely, in combination. Their association may seem logical because both these disorders are characterized by the suspicion of an autoimmune pathogenesis. We here report the case of a 8-year old girl, with no notable medical history, presenting with achromic macules and papular nonpruritic lesions (...) face of the knees. Two biopsies were performed. Histological examination of an achromic macula showed vitiligo with inflammatory reaction while histological examination of an infiltrated lesion allowed the diagnosis of scleroatrophic lichen. Significant clinical improvement was obtained by local treatment with dermocorticoids. Therefore, this pathological association between scleroatrophic lichen and vitiligo in our patient, highlights the key role of epidermal lichenoid inflammatory process

2018 The Pan African medical journal

111. Association of PTPN22 gene polymorphism with non-segmental vitiligo in South Indian Tamils (Full text)

Association of PTPN22 gene polymorphism with non-segmental vitiligo in South Indian Tamils Non-segmental vitiligo (NSV) is a depigmentation skin disease with loss of melanocytes in the skin.To evaluate whether the protein tyrosine phosphatase non-receptor type (PTPN22) single nucleotide polymorphism at +1858C/T had any association with non-segmental vitiligo in South Indian Tamils.Genomic DNA was extracted using the phenol-chloroform method, and PTPN22 +1858C/T polymorphism was assayed (...) by Taqman 5'allele discrimination assay. Protein levels were quantified by ELISA.We found that the allelic frequency of variants of PTPN22 (rs2476601) were significantly different between controls and cases showing a vitiligo risk in the South Indian Tamil population. PTPN22 levels were higher in the heterozygous CT genotype in NSV, when compared with that of the major variant CC genotype of rs2476601.This study suggests that the heterozygous CT genotype, of the PTPN22 SNP rs2476601, has a strong risk

2018 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

112. Nivolumab induced vitiligo-like lesions in a patient with metastatic squamous cell carcinoma of the lung (Full text)

Nivolumab induced vitiligo-like lesions in a patient with metastatic squamous cell carcinoma of the lung 30069410 2019 02 26 2072-1439 10 6 2018 Jun Journal of thoracic disease J Thorac Dis Nivolumab induced vitiligo-like lesions in a patient with metastatic squamous cell carcinoma of the lung. E481-E484 10.21037/jtd.2018.05.104 Nishino Kazumi K Department of Thoracic Oncology, Osaka International Cancer Institute, Osaka, Japan. Ohe Shuichi S Department of Dermatological Oncology, Osaka

2018 Journal of thoracic disease

113. Two reports of malignant melanoma arising within a new vitiligo-like depigmented patch (Full text)

Two reports of malignant melanoma arising within a new vitiligo-like depigmented patch 29998177 2019 02 26 2352-5126 4 6 2018 Jul JAAD case reports JAAD Case Rep Two reports of malignant melanoma arising within a new vitiligo-like depigmented patch. 573-575 10.1016/j.jdcr.2018.05.008 Francisco Gina G Department of Dermatology, Rutgers-Robert Wood Johnson Medical School, Somerset, New Jersey. Rao Babar K BK Department of Dermatology, Rutgers-Robert Wood Johnson Medical School, Somerset, New

2018 JAAD Case Reports

114. Autologous non-cultured melanocyte–keratinocyte transplantation in the treatment of vitiligo: patient selection and perspectives (Full text)

Autologous non-cultured melanocyte–keratinocyte transplantation in the treatment of vitiligo: patient selection and perspectives Autologous non-cultured melanocyte-keratinocyte transplantation procedure (MKTP) is one of the simplest cellular grafting techniques. Various modifications were done over the years to make the technique easier and more economical which led to its great popularity among dermatologists. Proper patient selection and good technical skills are essential for achieving

2018 Clinical, cosmetic and investigational dermatology

115. Dynamic thiol/disulphide homeostasis in vitiligo patients (Full text)

Dynamic thiol/disulphide homeostasis in vitiligo patients Vitiligo is an acquired depigmentation disorder with melanocyte destruction.To examine the thiol/disulphide balance in vitiligo patients and to compare the results with a healthy control group.Thirty-two patients with vitiligo and 35 healthy individuals were included in the study. Native thiol, disulfide and total thiol levels in plasma were evaluated using a new and automated spectrophotometric method. Disulphide/total thiol, disulphide (...) /native thiol and native thiol/total thiol levels were measured.There was no statistically significant difference between the two groups when the patient and control groups were compared in terms of thiol/disulphide balance (p > 0.05). There was no statistically significant difference in native thiol, disulphide and total thiol levels for vitiligo when compared with the control group (p > 0.005).In recent years, there have been numerous studies on the role of oxidative stress in the etiopathogenesis

2018 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

116. HO‐1 regulates the function of Treg: Association with the immune intolerance in vitiligo (Full text)

HO‐1 regulates the function of Treg: Association with the immune intolerance in vitiligo In vitiligo, cutaneous depigmentation is accompanied by increased T cell cytolytic activity targeting melanocytes, indicating that autoimmune tolerance is disrupted. The inhibited amount and function of Tregs have been indicated to be involved in the autoimmune intolerance in vitiligo, however, with the conclusion still controversial and the involved mechanism unknown. In this study, we explored (...) the molecular and cellular alterations accounting for the impaired Treg response in vitiligo. Our results showed that the amount of Tregs was drastically reduced in peripheral blood of active vitiligo patients. Furthermore, the immunoregulatory function of Tregs was attenuated, with lower expression of CTLA4, IL-10 and TGF-β. Moreover, the expression of HO-1, a functional modulator of Tregs, was decreased in vitiligo Tregs, and the concentrations of HO-1 metabolites, including bilirubin, CoHb and iron, were

2018 Journal of cellular and molecular medicine

117. Vitiligo Appearing after Oral Isotretinoin Therapy for Acne (Full text)

Vitiligo Appearing after Oral Isotretinoin Therapy for Acne Isotretinoin is an effective treatment for severe and scarring acne. In this report, we describe a case developing vitiligo after isotretinoin therapy for scarring acne. It is not known whether this was a coincidence or might be precipitated by the treatment.

2018 Case reports in dermatological medicine

118. Vitiligo and social acceptance (Full text)

Vitiligo and social acceptance Vitiligo is a chronic skin disease characterized by a total or partial loss of melanocytes from the epidermis and other tissues of the skin. It is placed in the class of secondary psychiatric disorders and can also lead to psychological problems. The main aim of this study was to assess social acceptance in vitiligo patients.This cross-sectional study was conducted on all of the patients (n=150) with vitiligo who were referred to dermatology clinics in Rafsanjan (...) significantly lower in women, in those with single marital status, in those with face and neck lesions, and in those with disease duration less than 5 years.The results showed that certain groups of patients with vitiligo are at greater risk of experiencing lower social acceptance.

2018 Clinical, cosmetic and investigational dermatology

119. Use of the 532-nm Q-switched neodymium-doped yttrium aluminum garnet laser for the treatment of recalcitrant repigmentation in vitiligo (Full text)

Use of the 532-nm Q-switched neodymium-doped yttrium aluminum garnet laser for the treatment of recalcitrant repigmentation in vitiligo 30003131 2019 02 26 2352-5126 4 6 2018 Jul JAAD case reports JAAD Case Rep Use of the 532-nm Q-switched neodymium-doped yttrium aluminum garnet laser for the treatment of recalcitrant repigmentation in vitiligo. 612-614 10.1016/j.jdcr.2018.04.010 Modi Krishna K Wayne State University School of Medicine, Detroit, Michigan. Mohammad Tasneem F TF Department

2018 JAAD Case Reports

120. Development of Vitiligo-Like Depigmentation after Treatment of Lentigo Maligna Melanoma with 5% Imiquimod Cream (Full text)

Development of Vitiligo-Like Depigmentation after Treatment of Lentigo Maligna Melanoma with 5% Imiquimod Cream A 69-year-old man presented with a black irregular patch on his left cheek. Skin biopsy revealed lentigo maligna melanoma in situ. He was treated via partial excision of the melanoma, followed by the application of 5% imiquimod cream every other night for 6 to 8 hours. The patient experienced severe local inflammation accompanied by burning, edema, and erythema, as well as oozing (...) and crusting. The patient discontinued using the imiquimod cream after 15 applications because of the inflammation. Depigmentation was noted in the treated area 3 months after the initiation of treatment with imiquimod cream. Histological examination using Melan-A staining of the depigmented area revealed an absence of melanocytes, which is consistent with vitiligo. The depigmented lesions improved considerably after a 5-year follow-up, and there was no recurrence of melanoma.

2018 Annals of dermatology

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