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Vitiligo

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101. Vitiligo Appearing after Oral Isotretinoin Therapy for Acne Full Text available with Trip Pro

Vitiligo Appearing after Oral Isotretinoin Therapy for Acne Isotretinoin is an effective treatment for severe and scarring acne. In this report, we describe a case developing vitiligo after isotretinoin therapy for scarring acne. It is not known whether this was a coincidence or might be precipitated by the treatment.

2018 Case reports in dermatological medicine

102. HO‐1 regulates the function of Treg: Association with the immune intolerance in vitiligo Full Text available with Trip Pro

HO‐1 regulates the function of Treg: Association with the immune intolerance in vitiligo In vitiligo, cutaneous depigmentation is accompanied by increased T cell cytolytic activity targeting melanocytes, indicating that autoimmune tolerance is disrupted. The inhibited amount and function of Tregs have been indicated to be involved in the autoimmune intolerance in vitiligo, however, with the conclusion still controversial and the involved mechanism unknown. In this study, we explored (...) the molecular and cellular alterations accounting for the impaired Treg response in vitiligo. Our results showed that the amount of Tregs was drastically reduced in peripheral blood of active vitiligo patients. Furthermore, the immunoregulatory function of Tregs was attenuated, with lower expression of CTLA4, IL-10 and TGF-β. Moreover, the expression of HO-1, a functional modulator of Tregs, was decreased in vitiligo Tregs, and the concentrations of HO-1 metabolites, including bilirubin, CoHb and iron, were

2018 Journal of cellular and molecular medicine

103. Identification of the Risk HLA-A Alleles and Autoantigen in Han Chinese Vitiligo Patients and the Association of CD8+T Cell Reactivity with Disease Characteristics Full Text available with Trip Pro

Identification of the Risk HLA-A Alleles and Autoantigen in Han Chinese Vitiligo Patients and the Association of CD8+T Cell Reactivity with Disease Characteristics BACKGROUND Multiple studies have implicated a role for CD8+T cell-mediated immune response to autoantigens in vitiligo. However, the antigen-specific T lymphocyte reactivity against the peptide epitopes is diverse among different world populations. This study aimed to identify the risk HLA-A allele in vitiligo and study CD8+ T cell (...) reactivity to 5 autoantigenic peptides in Han Chinese populations, and to analyze the association of CD8+ T cell reactivity with disease characteristics. MATERIAL AND METHODS The risk HLA-A allele was analyzed by case-control study. Enzyme linked immunospot (ELISPOT) assay was used to compare T cell reactivity to the 5 autoantigenic peptides between vitiligo patients and healthy controls, then we analyzed the association of CD8+ T cell reactivity to 2 positive peptides with disease activity and area

2018 Medical science monitor : international medical journal of experimental and clinical research

104. Vitiligo and social acceptance Full Text available with Trip Pro

Vitiligo and social acceptance Vitiligo is a chronic skin disease characterized by a total or partial loss of melanocytes from the epidermis and other tissues of the skin. It is placed in the class of secondary psychiatric disorders and can also lead to psychological problems. The main aim of this study was to assess social acceptance in vitiligo patients.This cross-sectional study was conducted on all of the patients (n=150) with vitiligo who were referred to dermatology clinics in Rafsanjan (...) significantly lower in women, in those with single marital status, in those with face and neck lesions, and in those with disease duration less than 5 years.The results showed that certain groups of patients with vitiligo are at greater risk of experiencing lower social acceptance.

2018 Clinical, cosmetic and investigational dermatology

105. Dynamic thiol/disulphide homeostasis in vitiligo patients Full Text available with Trip Pro

Dynamic thiol/disulphide homeostasis in vitiligo patients Vitiligo is an acquired depigmentation disorder with melanocyte destruction.To examine the thiol/disulphide balance in vitiligo patients and to compare the results with a healthy control group.Thirty-two patients with vitiligo and 35 healthy individuals were included in the study. Native thiol, disulfide and total thiol levels in plasma were evaluated using a new and automated spectrophotometric method. Disulphide/total thiol, disulphide (...) /native thiol and native thiol/total thiol levels were measured.There was no statistically significant difference between the two groups when the patient and control groups were compared in terms of thiol/disulphide balance (p > 0.05). There was no statistically significant difference in native thiol, disulphide and total thiol levels for vitiligo when compared with the control group (p > 0.005).In recent years, there have been numerous studies on the role of oxidative stress in the etiopathogenesis

2018 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

106. Genetic polymorphisms of GZMB and vitiligo: A genetic association study based on Chinese Han population Full Text available with Trip Pro

Genetic polymorphisms of GZMB and vitiligo: A genetic association study based on Chinese Han population Vitiligo is a skin disease that affects 1% of the population worldwide. Both environmental and genetic factors contribute to the risk of vitiligo. GZMB encodes the enzyme Granzyme B, which plays an important role in cytotoxic T cell-induced apoptosis, and it has been considered one of the candidate genes for vitiligo because of its connections with human immune system. Overall, 3,120 study (...) subjects with Chinese Han ancestry were recruited, and 15 pre-selected SNPs of GZMB were genotyped. Genetic association analyses were performed to evaluate the genetic risk of these SNPs to vitiligo. Further bioinformatic analyses were conducted to examine the potential biological function of targeted SNPs. The SNP rs8192917, a non-synonymous coding SNP, was identified to be significantly associated with the disease status of vitiligo, with OR = 1.39 and P = 1.92 × 10-8. Differences in the association

2018 Scientific reports

107. Cancer Risks in Vitiligo Patients: A Nationwide Population-Based Study in Taiwan Full Text available with Trip Pro

Cancer Risks in Vitiligo Patients: A Nationwide Population-Based Study in Taiwan Vitiligo is an autoimmune disease characterized by destruction of melanocytes and associated with other autoimmune disease. Whether the dysregulation of immune system enhances oncogenesis or not remains obscure. Until now, no nationwide population-based study has been conducted regarding this. As such, this paper aims to clarify cancer risk in vitiligo patients. A retrospective nationwide population-based cohort (...) study between 2000 and 2010 was performed based on data from the National Health Insurance Research Database of Taiwan. Standardized incidence ratios (SIRs) of cancers were analyzed. Among the 12,391 vitiligo patients (5364 males and 7027 females) and 48,531.09 person-years of observation, a total of 345 cancers were identified. Significantly increased SIRs were observed for prostate cancer in male patients, thyroid cancer and breast cancer in female patients and bladder cancers in both male

2018 International journal of environmental research and public health

108. Autologous non-cultured melanocyte–keratinocyte transplantation in the treatment of vitiligo: patient selection and perspectives Full Text available with Trip Pro

Autologous non-cultured melanocyte–keratinocyte transplantation in the treatment of vitiligo: patient selection and perspectives Autologous non-cultured melanocyte-keratinocyte transplantation procedure (MKTP) is one of the simplest cellular grafting techniques. Various modifications were done over the years to make the technique easier and more economical which led to its great popularity among dermatologists. Proper patient selection and good technical skills are essential for achieving

2018 Clinical, cosmetic and investigational dermatology

109. Association of PTPN22 gene polymorphism with non-segmental vitiligo in South Indian Tamils Full Text available with Trip Pro

Association of PTPN22 gene polymorphism with non-segmental vitiligo in South Indian Tamils Non-segmental vitiligo (NSV) is a depigmentation skin disease with loss of melanocytes in the skin.To evaluate whether the protein tyrosine phosphatase non-receptor type (PTPN22) single nucleotide polymorphism at +1858C/T had any association with non-segmental vitiligo in South Indian Tamils.Genomic DNA was extracted using the phenol-chloroform method, and PTPN22 +1858C/T polymorphism was assayed (...) by Taqman 5'allele discrimination assay. Protein levels were quantified by ELISA.We found that the allelic frequency of variants of PTPN22 (rs2476601) were significantly different between controls and cases showing a vitiligo risk in the South Indian Tamil population. PTPN22 levels were higher in the heterozygous CT genotype in NSV, when compared with that of the major variant CC genotype of rs2476601.This study suggests that the heterozygous CT genotype, of the PTPN22 SNP rs2476601, has a strong risk

2018 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

110. Two reports of malignant melanoma arising within a new vitiligo-like depigmented patch Full Text available with Trip Pro

Two reports of malignant melanoma arising within a new vitiligo-like depigmented patch 29998177 2019 02 26 2352-5126 4 6 2018 Jul JAAD case reports JAAD Case Rep Two reports of malignant melanoma arising within a new vitiligo-like depigmented patch. 573-575 10.1016/j.jdcr.2018.05.008 Francisco Gina G Department of Dermatology, Rutgers-Robert Wood Johnson Medical School, Somerset, New Jersey. Rao Babar K BK Department of Dermatology, Rutgers-Robert Wood Johnson Medical School, Somerset, New

2018 JAAD Case Reports

111. Neural and Endocrinal Pathobiochemistry of Vitiligo: Comparative Study for a Hypothesized Mechanism Full Text available with Trip Pro

Neural and Endocrinal Pathobiochemistry of Vitiligo: Comparative Study for a Hypothesized Mechanism The etiology of vitiligo is still unclear. The aim is to investigate a neural and hormonal etio-pathology of vitiligo. Sixty acrofacial vitiligo patients were divided into two subgroups as active vitiligo patients group (AVPs; n = 35) and stable vitiligo patients group (SVP; n = 25). Forty healthy subjects without any systemic or dermatological disease were used as controls. Blood samples were (...) . There was a significant decrease in serum level of ACTH in either AVP or SVP than control and in AVP than SVP group. In conclusion, there are some neural and endocrine markers that play a pivotal role in pathogenesis and/or consequences of vitiligo. The abnormally disturbed levels of theses markers lead to melanocyte destruction and/or depigmentation.

2018 Frontiers in endocrinology

112. Clinical and Molecular Aspects of Vitiligo Treatments Full Text available with Trip Pro

Clinical and Molecular Aspects of Vitiligo Treatments Vitiligo is an asymptomatic but cosmetically disfiguring disorder that results in the formation of depigmented patches on skin and/or mucosae. Vitiligo can be segmental or non-segmental depending upon the morphology of the clinical involvement. It can also be classified as progressing or stable based on the activity of the disease. Further, the extent of involvement can be limited (localized disease) or extensive (generalized disease (...) ). The treatment of vitiligo therefore depends on the clinical classification/characteristics of the disease and usually comprises of 2 strategies. The first involves arresting the progression of active disease (to provide stability) in order to limit the area involved by depigmentation. The second strategy aims at repigmentation of the depigmented area. It is also important to maintain the disease in a stable phase and to prevent relapse. Accordingly, a holistic treatment approach for vitiligo should

2018 International journal of molecular sciences

113. Porphyria Cutanea Tarda Presenting with Scleroderma, Ichthyosis, Alopecia, and Vitiligo Full Text available with Trip Pro

Porphyria Cutanea Tarda Presenting with Scleroderma, Ichthyosis, Alopecia, and Vitiligo Porphyria cutanea tarda (PCT) is a cutaneous porphyria that presents later in life with cutaneous findings in sun-exposed sites. We report a complex case of PCT in a 67-year-old woman with an unusual constellation of cutaneous findings: scleroderma, acquired ichthyosis, and nonscarring alopecia. Possible triggers for her PCT include tamoxifen treatment for breast cancer and carrier status (...) of the hemochromatosis gene. High-dose chloroquine was used to successfully achieve clinical remission and normalize her uroporphyrins. While on chloroquine she developed extensive classic vitiligo. It is not clear if this is another feature of her complex and unusual PCT, or a consequence of her antimalarial therapy.

2018 Case reports in dermatology

114. Investigation the Relationship between Skin Involvement Severity and Hearing Loss Severity in Vitiligo Patients Full Text available with Trip Pro

Investigation the Relationship between Skin Involvement Severity and Hearing Loss Severity in Vitiligo Patients Vitiligo is a common acquired depigmented systemic disorder influencing the entire pigmentary system including Cochlear melanocytes and vestibular system in the inner ear. Vitiligo can leads to social negative impact and poorer quality of life among these patients. This study was conducted to investigate the relationship between skin involvement severity and hearing loss severity (...) among vitiligo patients.This cross-sectional study was performed on 98 patients with vitiligo referred to the dermatology clinic of Shahid Beheshti Hospital of Kashan during 2012-2014. Using Vitiligo Area Severity Index (VASI), the skin involvement was evaluated by a dermatologist. Then, patients referred to an otolaryngologist, and after otoscopic examination, they underwent audiometric testing including Audiometry, Tympanometry and Auditory Brainstem Response (ABR tests. Patients aged 10-50 years

2018 Materia socio-medica

115. Utility of dermoscopy for evaluating the therapeutic efficacy of tacrolimus ointment plus 308-nm excimer laser combination therapy in localized vitiligo patients Full Text available with Trip Pro

Utility of dermoscopy for evaluating the therapeutic efficacy of tacrolimus ointment plus 308-nm excimer laser combination therapy in localized vitiligo patients The aim of the present study was to assess the function of dermoscopy in evaluating the therapeutic efficacy of tacrolimus ointment plus 308-nm excimer laser combination therapy in patients with localized vitiligo. A total of 147 patients with localized vitiligo (progressive disease, n=92; stable period, n=55) were enrolled (...) and received combination therapy for 12 weeks. The condition of the skin lesions was monitored by dermoscopy and visual observation. At the initial visit, skin lesions were observed in 61 progressive and 19 stable patients. Residual perifollicular pigmentation was more abundant in progressive-stage patients than in stable-stage patients, whereas the presence of perilesional hyperpigmentation was obviously lower in patients with progressive vitiligo. After 12 weeks of combination therapy, marked differences

2018 Experimental and therapeutic medicine

116. Nivolumab induced vitiligo-like lesions in a patient with metastatic squamous cell carcinoma of the lung Full Text available with Trip Pro

Nivolumab induced vitiligo-like lesions in a patient with metastatic squamous cell carcinoma of the lung 30069410 2019 02 26 2072-1439 10 6 2018 Jun Journal of thoracic disease J Thorac Dis Nivolumab induced vitiligo-like lesions in a patient with metastatic squamous cell carcinoma of the lung. E481-E484 10.21037/jtd.2018.05.104 Nishino Kazumi K Department of Thoracic Oncology, Osaka International Cancer Institute, Osaka, Japan. Ohe Shuichi S Department of Dermatological Oncology, Osaka

2018 Journal of thoracic disease

117. Association rare: lichen scléroatrophique extragénital et vitiligo inflammatoire chez un enfant Full Text available with Trip Pro

Association rare: lichen scléroatrophique extragénital et vitiligo inflammatoire chez un enfant Scleroatrophic lichen (SL) and vitiligo are two depigmenting disorders which may occur separately or, rarely, in combination. Their association may seem logical because both these disorders are characterized by the suspicion of an autoimmune pathogenesis. We here report the case of a 8-year old girl, with no notable medical history, presenting with achromic macules and papular nonpruritic lesions (...) face of the knees. Two biopsies were performed. Histological examination of an achromic macula showed vitiligo with inflammatory reaction while histological examination of an infiltrated lesion allowed the diagnosis of scleroatrophic lichen. Significant clinical improvement was obtained by local treatment with dermocorticoids. Therefore, this pathological association between scleroatrophic lichen and vitiligo in our patient, highlights the key role of epidermal lichenoid inflammatory process

2018 The Pan African medical journal

118. Pregnancy Outcomes in Patients with Vitiligo: A Nationwide Population-based Cohort Study from Korea. (Abstract)

Pregnancy Outcomes in Patients with Vitiligo: A Nationwide Population-based Cohort Study from Korea. Vitiligo is a chronic autoimmune skin disorder affecting 1% of populations worldwide. Few large-scale studies have explored adverse pregnancy outcomes in patients with vitiligo.To investigate adverse pregnancy outcomes in patients with vitiligo.We performed a retrospective cohort study on 4738 pregnancies of women with vitiligo and 47,380 pregnancies of age-matched controls without vitiligo (...) using the Korean National Health Insurance Claims database from 2007 to 2016. Multivariate logistic regression models were used to evaluate the associations between vitiligo and pregnancy outcomes, including live births, spontaneous abortion, cesarean delivery, preterm delivery, gestational diabetes mellitus, stillbirth, pre-eclampsia/eclampsia, and intrauterine growth retardation.Patients with vitiligo exhibited a significantly lower live birth rate (odds ratio, 0.870; 95% confidence interval

2018 Journal of American Academy of Dermatology

119. Epidermal melanocytes of segmental vitiligo show altered expression of E-cadherin, but not P-cadherin. (Abstract)

Epidermal melanocytes of segmental vitiligo show altered expression of E-cadherin, but not P-cadherin. 29341072 2018 05 22 1365-2133 178 5 2018 May The British journal of dermatology Br. J. Dermatol. Epidermal melanocytes in segmental vitiligo show altered expression of E-cadherin, but not P-cadherin. 1204-1206 10.1111/bjd.16352 Grill C C Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay, France. University Paris-Sud, University

2018 British Journal of Dermatology

120. Views and experiences of seeking information and help for vitiligo: a qualitative study of written accounts. Full Text available with Trip Pro

Views and experiences of seeking information and help for vitiligo: a qualitative study of written accounts. Vitiligo is a relatively common autoimmune condition causing loss of skin pigment. Around 1 in 100 people in the UK develop vitiligo. It can have a significant impact on quality of life for many of those affected. How people access information and help for vitiligo may influence how they manage such impact. We aimed to explore people's views and experiences of seeking health information (...) and help for vitiligo.Qualitative analysis of free-text responses to four open-ended questions in an online survey.Online survey conducted in the UK between February and March 2016.A survey link was emailed to 675 members of The Vitiligo Society, a UK-based charity providing information and support for people with vitiligo. One hundred and sixty-one members responded to the survey (24%).Many participants wrote extensive free text, often reporting frustration with help-seeking. They perceived general

2018 BMJ open

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