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Vitiligo

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81. Development of Vitiligo-Like Depigmentation after Treatment of Lentigo Maligna Melanoma with 5% Imiquimod Cream (PubMed)

Development of Vitiligo-Like Depigmentation after Treatment of Lentigo Maligna Melanoma with 5% Imiquimod Cream A 69-year-old man presented with a black irregular patch on his left cheek. Skin biopsy revealed lentigo maligna melanoma in situ. He was treated via partial excision of the melanoma, followed by the application of 5% imiquimod cream every other night for 6 to 8 hours. The patient experienced severe local inflammation accompanied by burning, edema, and erythema, as well as oozing (...) and crusting. The patient discontinued using the imiquimod cream after 15 applications because of the inflammation. Depigmentation was noted in the treated area 3 months after the initiation of treatment with imiquimod cream. Histological examination using Melan-A staining of the depigmented area revealed an absence of melanocytes, which is consistent with vitiligo. The depigmented lesions improved considerably after a 5-year follow-up, and there was no recurrence of melanoma.

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2018 Annals of dermatology

82. Use of the 532-nm Q-switched neodymium-doped yttrium aluminum garnet laser for the treatment of recalcitrant repigmentation in vitiligo (PubMed)

Use of the 532-nm Q-switched neodymium-doped yttrium aluminum garnet laser for the treatment of recalcitrant repigmentation in vitiligo 30003131 2019 02 26 2352-5126 4 6 2018 Jul JAAD case reports JAAD Case Rep Use of the 532-nm Q-switched neodymium-doped yttrium aluminum garnet laser for the treatment of recalcitrant repigmentation in vitiligo. 612-614 10.1016/j.jdcr.2018.04.010 Modi Krishna K Wayne State University School of Medicine, Detroit, Michigan. Mohammad Tasneem F TF Department

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2018 JAAD Case Reports

83. Dynamic thiol/disulphide homeostasis in vitiligo patients (PubMed)

Dynamic thiol/disulphide homeostasis in vitiligo patients Vitiligo is an acquired depigmentation disorder with melanocyte destruction.To examine the thiol/disulphide balance in vitiligo patients and to compare the results with a healthy control group.Thirty-two patients with vitiligo and 35 healthy individuals were included in the study. Native thiol, disulfide and total thiol levels in plasma were evaluated using a new and automated spectrophotometric method. Disulphide/total thiol, disulphide (...) /native thiol and native thiol/total thiol levels were measured.There was no statistically significant difference between the two groups when the patient and control groups were compared in terms of thiol/disulphide balance (p > 0.05). There was no statistically significant difference in native thiol, disulphide and total thiol levels for vitiligo when compared with the control group (p > 0.005).In recent years, there have been numerous studies on the role of oxidative stress in the etiopathogenesis

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2018 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

84. Vitiligo and social acceptance (PubMed)

Vitiligo and social acceptance Vitiligo is a chronic skin disease characterized by a total or partial loss of melanocytes from the epidermis and other tissues of the skin. It is placed in the class of secondary psychiatric disorders and can also lead to psychological problems. The main aim of this study was to assess social acceptance in vitiligo patients.This cross-sectional study was conducted on all of the patients (n=150) with vitiligo who were referred to dermatology clinics in Rafsanjan (...) significantly lower in women, in those with single marital status, in those with face and neck lesions, and in those with disease duration less than 5 years.The results showed that certain groups of patients with vitiligo are at greater risk of experiencing lower social acceptance.

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2018 Clinical, cosmetic and investigational dermatology

85. Pregnancy Outcomes in Patients with Vitiligo: A Nationwide Population-based Cohort Study from Korea. (PubMed)

Pregnancy Outcomes in Patients with Vitiligo: A Nationwide Population-based Cohort Study from Korea. Vitiligo is a chronic autoimmune skin disorder affecting 1% of populations worldwide. Few large-scale studies have explored adverse pregnancy outcomes in patients with vitiligo.To investigate adverse pregnancy outcomes in patients with vitiligo.We performed a retrospective cohort study on 4738 pregnancies of women with vitiligo and 47,380 pregnancies of age-matched controls without vitiligo (...) using the Korean National Health Insurance Claims database from 2007 to 2016. Multivariate logistic regression models were used to evaluate the associations between vitiligo and pregnancy outcomes, including live births, spontaneous abortion, cesarean delivery, preterm delivery, gestational diabetes mellitus, stillbirth, pre-eclampsia/eclampsia, and intrauterine growth retardation.Patients with vitiligo exhibited a significantly lower live birth rate (odds ratio, 0.870; 95% confidence interval

2018 Journal of American Academy of Dermatology

86. Critical appraisal of the oxidative stress pathway in vitiligo: a systematic review and meta-analysis. (PubMed)

Critical appraisal of the oxidative stress pathway in vitiligo: a systematic review and meta-analysis. The pathogenesis of vitiligo remains a topic of extensive debate. This is partly due to the moderate efficacy of current treatments. The role of the oxidative stress pathway in vitiligo is a popular although controversial research topic.To clarify the role of the oxidative stress pathway in vitiligo compared to other inflammatory skin disorders and to assess the therapeutic role (...) of antioxidants.We conducted a systematic search of the existing literature on the aberrancies of the oxidative stress pathway in vitiligo. Subsequently, the efficacy of both topical and oral antioxidants in clinical trials was investigated.A deregulated oxidative pathway is clearly evident with elevated superoxide dismutase, decreased catalase and increased lipid peroxidation. However, similar results have been obtained in other inflammatory skin diseases such as psoriasis, atopic dermatitis, lichen planus

2018 Journal of the European Academy of Dermatology and Venereology

87. Predictive Model for Response Rate to Narrowband Ultraviolet B Phototherapy in Vitiligo: A Retrospective Cohort Study of 579 Patients. (PubMed)

Predictive Model for Response Rate to Narrowband Ultraviolet B Phototherapy in Vitiligo: A Retrospective Cohort Study of 579 Patients. Vitiligo is an acquired depigmenting disorder. To date, there is no predictive model for its response rate to narrowband ultraviolet B (NBUVB) phototherapy. The aim of this study was to investigate the different types of response of patients with non-segmental vitiligo undergoing NBUVB 3 times a week. Many patients who were previously considered non-responders

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2018 Acta Dermato-Venereologica

88. Epidermal melanocytes of segmental vitiligo show altered expression of E-cadherin, but not P-cadherin. (PubMed)

Epidermal melanocytes of segmental vitiligo show altered expression of E-cadherin, but not P-cadherin. 29341072 2018 05 22 1365-2133 178 5 2018 May The British journal of dermatology Br. J. Dermatol. Epidermal melanocytes in segmental vitiligo show altered expression of E-cadherin, but not P-cadherin. 1204-1206 10.1111/bjd.16352 Grill C C Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes, Orsay, France. University Paris-Sud, University

2018 British Journal of Dermatology

89. Views and experiences of seeking information and help for vitiligo: a qualitative study of written accounts. (PubMed)

Views and experiences of seeking information and help for vitiligo: a qualitative study of written accounts. Vitiligo is a relatively common autoimmune condition causing loss of skin pigment. Around 1 in 100 people in the UK develop vitiligo. It can have a significant impact on quality of life for many of those affected. How people access information and help for vitiligo may influence how they manage such impact. We aimed to explore people's views and experiences of seeking health information (...) and help for vitiligo.Qualitative analysis of free-text responses to four open-ended questions in an online survey.Online survey conducted in the UK between February and March 2016.A survey link was emailed to 675 members of The Vitiligo Society, a UK-based charity providing information and support for people with vitiligo. One hundred and sixty-one members responded to the survey (24%).Many participants wrote extensive free text, often reporting frustration with help-seeking. They perceived general

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2018 BMJ open

90. Interventions for Vitiligo. (PubMed)

Interventions for Vitiligo. Which interventions are associated with highest efficacy and fewest adverse events for treating vitiligo?Combination therapies, particularly those involving some form of light (ie, narrowband UV-B) were associated with more improved repigmentation than monotherapies. There was limited evidence to support the association of UV-A alone and UV-B alone with repigmentation for vitiligo. There was moderate evidence to support the association of UV-A and UV-B, when used (...) in combination with psoralens, topical corticosteroids, vitamin D analogues, fluorouracil, azathioprine, and oral prednisolone with improved outcomes for vitiligo. However, combination therapies were associated with more adverse effects.

2016 JAMA

91. The Investigation on the Expression of High Mobility Group Protein Box-1 (HMGB1) in Peripheral Blood of Vitiligo Patients and Healthy Controls According to Clinical Features, Treatment and Disease Activity

The Investigation on the Expression of High Mobility Group Protein Box-1 (HMGB1) in Peripheral Blood of Vitiligo Patients and Healthy Controls According to Clinical Features, Treatment and Disease Activity The Investigation on the Expression of High Mobility Group Protein Box-1 (HMGB1) in Peripheral Blood of Vitiligo Patients and Healthy Controls According to Clinical Features, Treatment and Disease Activity - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers (...) : refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Investigation on the Expression of High Mobility Group Protein Box-1 (HMGB1) in Peripheral Blood of Vitiligo Patients and Healthy Controls According to Clinical Features, Treatment and Disease Activity The safety and scientific validity

2018 Clinical Trials

92. Cutaneous expression of thymic stromal lymphopoietin (TSLP) in vitiligo patients: a case-control study. (PubMed)

Cutaneous expression of thymic stromal lymphopoietin (TSLP) in vitiligo patients: a case-control study. Thymic stromal lymphopoietin (TSLP) is a major pro-allergic cytokine promoting T helper-2 responses. Our aim was to study and verify the hypothesis of the role of TSLP in the pathogenesis of vitiligo.This case-control study was conducted on 25 patients with generalized non-segmental vitiligo (recruited from the Dermatology outpatient clinic, Kasr El Ainy, Faculty of Medicine, Cairo University (...) ) and 25 healthy controls fulfilling the inclusion criteria over a period of 7 months (January 2017-July 2017). Patients underwent complete medical history, detailed assessment of vitiligo, and photographic documentation. Skin biopsies were taken from the back from both patients' vitiliginous skin and from normal skin of controls for which relative TSLP messenger RNA (mRNA) tissue expression levels were measured using quantitative real-time polymerase chain reaction technique.There was a statistically

2018 International Journal of Dermatology

93. Association of human beta-defensin 1 gene polymorphisms with nonsegmental vitiligo. (PubMed)

Association of human beta-defensin 1 gene polymorphisms with nonsegmental vitiligo. Vitiligo is a pigmentation disorder of autoimmune aetiology. Polymorphisms in beta-defensin genes have been linked to a predisposition to some autoimmune disorders.To evaluate the role of polymorphisms in DEFB1, the gene encoding for human beta-defensin (HBD)-1 and its 5' untranslated region in nonsegmental vitiligo.In total, 354 participants [171 patients with non-segmental vitiligo and 183 age and sex-matched (...) healthy controls (HCs)], were genotyped by the PCR-restriction fragment length polymorphism (RFLP) method. For 80 of these individuals (40 patients and -40 HCs) serum HBD-1 was also measured by ELISA.The -44 G allele, CG genotype and GGG haplotype increased the risk for vitiligo (P < 0.02 in all cases), whereas the -20 AA genotype seems to be protective (P = 0.04). Serum HBD-1 levels were lower in patients with vitiligo than in HCs (P < 0.01), as well as in patients with active vitiligo compared

2018 Clinical & Experimental Dermatology

94. Comorbidities in vitiligo: comprehensive review. (PubMed)

Comorbidities in vitiligo: comprehensive review. Vitiligo is a common skin disorder characterized by idiopathic, progressive cutaneous hypomelanosis. Vitiligo is associated with several comorbid autoimmune, systemic, and dermatological diseases, primarily thyroid disease, alopecia areata, diabetes mellitus, pernicious anemia, systemic lupus erythematosus, rheumatoid arthritis, Addison's disease, inflammatory bowel disease, Sjögren's syndrome, dermatomyositis, scleroderma, ocular (...) and audiological abnormalities, psoriasis, and atopic dermatitis. It is essential to increase awareness of these comorbidities in order to improve the disease burden and quality of life of patients with vitiligo. Herein, we review the association with the most frequent comorbidities associated with vitiligo.© 2018 The International Society of Dermatology.

2018 International Journal of Dermatology

95. Vitiligo remitting with tocilizumab. (PubMed)

Vitiligo remitting with tocilizumab. 29888453 2019 01 18 1468-3083 33 1 2019 Jan Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Vitiligo remitting with tocilizumab. e20 10.1111/jdv.15117 Bunker C B CB University College London Hospitals, 250 Euston Road, London, NW1 2AF, UK. Manson J J University College London Hospitals, 250 Euston Road, London, NW1 2AF, UK. eng Letter 2018 06 28 England J Eur Acad Dermatol Venereol 9216037 0926-9959 2018 6

2018 Journal of the European Academy of Dermatology and Venereology

96. Decreased choroidal thickness in vitiligo patients. (PubMed)

Decreased choroidal thickness in vitiligo patients. Vitiligo is a disease characterized by depigmented macules and patches that occur as a result of the loss of functional melanocytes from the affected skin through a mechanism which has not been elucidated yet. Destruction of pigment cells in vitiligo may not remain limited to the skin; the eyelashes, iris, ciliary body, choroid, retinal pigment epithelium and meninges may also be affected. This study aims to compare the choroidal thickness (...) of patients with and without vitiligo using optical coherence tomography (OCT).Spectral-domain optical coherence tomography (SD-OCT) (Retina Scan Advanced RS-3000 NIDEK, Japan) instrument (with λ = 840 nm, 27,000 A-scans/second and 5 μm axial resolution) was used for the imaging. Statistical analysis was performed using SPSS 21.0 software package.In all values except optic nevre area measurements, the choroidal thickness of all vitiligo patients was found out to be thinner compared to the control group.In

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2018 BMC Ophthalmology

97. The early repigmentation pattern of vitiligo is related to the source of melanocytes and by the choice of therapy: a retrospective cohort study. (PubMed)

The early repigmentation pattern of vitiligo is related to the source of melanocytes and by the choice of therapy: a retrospective cohort study. Patients with vitiligo present with different repigmentation patterns in the early recovery stage.To analyze the relationships between early repigmentation patterns in vitiliginous patches, their clinical characteristics, and therapeutic choices.Patients with vitiligo seen in the Department of Dermatology, The First Affiliated Hospital of Nanjing (...) ), progressive stage (P = 0.044), and truncal lesions treated with TVDAs (P < 0.001).The different repigmentation patterns of vitiligo lesions depend on the different source and status of melanocytes and their abilities to produce melanin on the choice of therapy.© 2018 The International Society of Dermatology.

2018 International Journal of Dermatology

98. Efficacy and safety of noncultured melanocyte-keratinocyte transplant procedure for vitiligo and other leukodermas: a critical analysis of the evidence. (PubMed)

Efficacy and safety of noncultured melanocyte-keratinocyte transplant procedure for vitiligo and other leukodermas: a critical analysis of the evidence. Vitiligo is an acquired pigmentary skin of depigmentation occurring secondary to melanocyte destruction. Vitiligo and other leukodermas have a profound impact on quality of life. Current therapies include medical options, such as phototherapy, topical and systemic corticosteroids, topical calcineurin inhibitors, immunomodulators (...) , and antioxidiants, and surgical options. Surgical options provide melanocytic cells to previously depigmented areas and use either tissue grafting or cellular grafting methods. Topical treatments are often insufficient, and many of the current surgical procedures have shown variable response rates. In this review, we discuss the process of the cellular grafting melanocyte-keratinocyte transplantation procedure (MKTP) and critically analyze its efficacy and safety in the treatment of vitiligo and other

2018 International Journal of Dermatology

99. A prospective right-left comparative study to evaluate the efficacy and tolerability of combination of NB-UVB and topical bimatoprost 0.03% eye drops versus NB-UVB given alone in patients of vitiligo vulgaris. (PubMed)

A prospective right-left comparative study to evaluate the efficacy and tolerability of combination of NB-UVB and topical bimatoprost 0.03% eye drops versus NB-UVB given alone in patients of vitiligo vulgaris. 29444382 2018 03 09 1468-3083 2018 Feb 14 Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol A prospective right-left comparative study to evaluate the efficacy and tolerability of combination of NB-UVB and topical bimatoprost 0.03% eye (...) drops versus NB-UVB given alone in patients of vitiligo vulgaris. 10.1111/jdv.14882 Sharma S S Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Parsad D D Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Bhattacharjee R R Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research

2018 Journal of the European Academy of Dermatology and Venereology

100. Once weekly targeted excimer light produced modest re-pigmentation of vitiligo over a 20-week period. (PubMed)

Once weekly targeted excimer light produced modest re-pigmentation of vitiligo over a 20-week period. 29419905 2018 03 05 1468-3083 2018 Feb 08 Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Once weekly targeted excimer light produced modest repigmentation of vitiligo over a 20-week period. 10.1111/jdv.14853 Ayob S S Department of Dermatology, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK. Cockayne S E SE Department of Dermatology, Royal

2018 Journal of the European Academy of Dermatology and Venereology

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