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Vitiligo

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81. Platelet-rich plasma versus combined fractional carbon dioxide laser with platelet-rich plasma in the treatment of vitiligo: a comparative study. Full Text available with Trip Pro

Platelet-rich plasma versus combined fractional carbon dioxide laser with platelet-rich plasma in the treatment of vitiligo: a comparative study. The aim of this study was to assess the efficacy of platelet-rich plasma (PRP) vs combined fractional CO2 (Fr: CO2) laser with PRP in the treatment of stable nonsegmental vitiligo (NSV) lesions.This prospective, randomized, intrapatient, comparative controlled study was conducted between June 2014 and June 2016 at National Institute of Laser Enhanced (...) Sciences (NILES), Cairo University, Cairo, Egypt. Thirty NSV patients were treated with PRP, Fr: CO2 laser, and combined Fr: CO2 laser with PRP. Intrapatient lesions were divide randomly into four groups. Each group was treated by one modality. The fourth group served as a control.Patients received six treatment sessions with 2-week interval for 3 months and were followed up after 3 months.A highly significant reduction was demonstrated through vitiligo analysis by computer-assisted grid (VACAG

2018 Clinical, cosmetic and investigational dermatology Controlled trial quality: uncertain

82. Intradermal injection of Fluorouracil versus triamcinolone in localized vitiligo treatment. (Abstract)

Intradermal injection of Fluorouracil versus triamcinolone in localized vitiligo treatment. Vitiligo is an autoimmune disease with a prevalence of 1.22% in Egypt. Intralesional steroids use in localized vitiligo treatment still a matter of debate. Fluorouracil was tried in vitiligo treatment after lesion dermabrasion, ablative laser, or micro-needling. The study aimed to compare the efficacy of intradermal fluorouracil and triamcinolone acetonide without any adjuvant therapy in localized (...) vitiligo treatment.Sixty patients with localized non-segmental stable vitiligo were assigned randomly and equally into groups. Patients subjected to intradermal injection of either fluorouracil (50 mg/mL), triamcinolone acetonide (3 mg/mL) or an equal mixture of both drugs. All patients had four treatment sessions every 2 weeks were followed up for 6 months.Intradermal fluorouracil showed the best overall improvement (median 52.27, IQR 36.25-68.18) when compared with triamcinolone (median 13.86, IQR

2018 Journal of cosmetic dermatology Controlled trial quality: uncertain

83. Potential emerging treatment in vitiligo using Er:YAG in combination with 5FU and clobetasol. (Abstract)

Potential emerging treatment in vitiligo using Er:YAG in combination with 5FU and clobetasol. Vitiligo is a pigmentary disorder of skin affecting at least 1% of the world population of all races in both sexes. Its importance is mainly due to subsequent social and psychological problems rather than clinical complications. Various treatment choices are available for vitiligo; however, laser-based courses have shown to give more acceptable results.The aim of this trial was to evaluate the efficacy (...) of Er:YAG laser as a supplementary medicine to topical 5FU and clobetasol in vitiligo patients.Two comparable vitiligo patches from 38 eligible patients were randomized to receive topical 5FU and clobetasol in control group and additional Er:YAG laser in intervention group. Major outcomes of interest were the size of patch and pigmentation score at randomization and 2 and 4 months after therapy.Final sample included 18 (47%) male patients and age of 35.66±8.04. The performance Er:YAG group was superior

2018 Journal of cosmetic dermatology Controlled trial quality: uncertain

84. Combined treatment with fractional carbon dioxide laser, autologous platelet-rich plasma, and narrow band ultraviolet B for vitiligo in different body sites: A prospective, randomized comparative trial. (Abstract)

Combined treatment with fractional carbon dioxide laser, autologous platelet-rich plasma, and narrow band ultraviolet B for vitiligo in different body sites: A prospective, randomized comparative trial. Multiple treatment options are introduced in treatment of vitiligo but the response is unsatisfactory.In this prospective, randomized, comparative trial, we studied the effect of combined treatment with fractional carbon dioxide (CO2 ) laser, platelet-rich plasma (PRP) injection, and narrowband (...) ultraviolet B (NB-UVB) for stable nonsegmental vitiligo regarding repigmentation grade, patient's satisfaction, and side effects.Eighty adult patients with localized nonsegmental vitiligo were enrolled in this study. The patients were randomly categorized to receive 4 lines of treatment; fractional CO2 laser, PRP, combined fractional CO2 laser and PRP, and combined fractional CO2 laser and NB-UVB. The treatment period was 2 months. Patients were clinically evaluated 3 months after the last treatment

2018 Journal of cosmetic dermatology Controlled trial quality: uncertain

85. Evaluation of Using Fractional CO<sub>2</sub> Laser plus NB-UVB versus NB-UVB Alone in Inducing Marginal Repigmentation of Vitiligo Lesions. (Abstract)

Evaluation of Using Fractional CO2 Laser plus NB-UVB versus NB-UVB Alone in Inducing Marginal Repigmentation of Vitiligo Lesions. Vitiligo is a common depigmenting skin disorder, characterized by patchy loss of skin color and finding effective treatment has remained a challenging issue.A paired (half-body) randomized clinical trial study was done to compare the efficacy and the safety of narrowband ultraviolet B (NB-UVB) plus fractional CO2 versus NB-UVB alone in stimulation (...) of marginal repigmentation of vitiliginous patches. One side of the body was randomly treated with a fractional CO2 laser and NB-UVB twice weekly, while the other side was exposed only to NB-UVB with the same manner.Thirty patients with the non-segmental stable vitiligo and mean age of 43 ± 15 years completed a 16-week treatment period with NB-UVB on one side of the body and fractional CO2 laser therapy with NB-UBV on the other side. In addition to the higher rate of response in the combination side

2018 Journal of Dermatological Treatment Controlled trial quality: uncertain

86. Vitiligo-like lesions in a patient treated with nivolumab for renal cell carcinoma. Full Text available with Trip Pro

Vitiligo-like lesions in a patient treated with nivolumab for renal cell carcinoma. The introduction of immune check-point inhibitors (ICIs) in the treatment of solid neoplasms is associated with the need to know and manage a new type of side effects that are commonly defined immune-mediated adverse events. Dermatologic immune-mediated adverse events are relatively common. Vitiligo-like lesions, defined as hypopigmented skin lesions, have already been associated with the use of ICIs (...) in particular in patients with malignant melanoma, probably due to a common autoimmune mechanism against both melanoma cells and normal melanocytes. The onset of vitiligo-like lesions is very rare in non-melanoma patients and nowadays only few cases are described in the literature.We described the case of a heavily pre-treated woman affected by renal cell carcinoma that has been treated with nivolumab for 2 years obtaining a stabilization of disease after an initial mild progression. After 9 months from

2018 Medicine

87. Involvement of non melanocytic skin cells in vitiligo. Full Text available with Trip Pro

Involvement of non melanocytic skin cells in vitiligo. Despite melanocytes are the key players in vitiligo, a continuous cross-talk between epidermal and dermal cells may strictly affect their functionality, in both lesional skin and non-lesional skin. Focusing on this interplay, we have reviewed existing literature supporting evidence on cellular and functional alterations of surrounding epidermal keratinocytes, extracellular matrix (ECM) proteins and fibroblasts in the underlying dermal (...) compartment that may contribute to melanocyte disappearance in vitiligo. We have also examined some clinical and therapeutic aspects of the disease to sustain the non-exclusive involvement of melanocytes within vitiligo. As a result, a different and more complex scenario has appeared that may enable to provide better understanding about origins and progress of vitiligo and that should be considered in the evaluation of new treatment approaches.© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons

2018 Experimental Dermatology

88. Activation of melanoblasts and melanocytes after treatment with monochromatic excimer light and narrowband-ultraviolet B of skin of vitiligo patients. (Abstract)

Activation of melanoblasts and melanocytes after treatment with monochromatic excimer light and narrowband-ultraviolet B of skin of vitiligo patients. Vitiligo is a hypopigmentation disease characterized by achromatic or hypochromatic macules in several sites of human skin. Although monochromatic excimer light (MEL) and narrowband-ultraviolet B (NB-UVB) have recently been used for efficacious treatment of vitiligo, the repigmentation process and role of melanocytes/melanoblasts are not well (...) known.White macules of 28 vitiligo patients were repeatedly exposed with MEL/NB-UVB. After the exposures, punch biopsies of the center and edge of the lesional skin in addition to normal skin were fixed and processed to dopa and combined dopa-premelanin reactions. Melanocytes positive to the dopa reaction and melanoblasts/melanocytes positive to the combined dopa-premelanin reaction were surveyed.Two repigmentation patterns were observed; one was "marginal" and the other was "perifollicular." Although

2018 International Journal of Dermatology

89. Four compartment method as an efficacious and simplified technique for autologous non-cultured epidermal cell suspension preparation in vitiligo surgery: A randomized, active-controlled study. Full Text available with Trip Pro

Four compartment method as an efficacious and simplified technique for autologous non-cultured epidermal cell suspension preparation in vitiligo surgery: A randomized, active-controlled study. Autologous non-cultured epidermal cell suspension (NCES) is a successful surgical method for repigmentation of stable, refractory vitiligo. The need for laboratory equipment and expertise restricts its use to only a few research centres; hence, there is a requisite to simplify the technique of NCES (...) preparation.To evaluate the efficacy of NCES prepared by four compartment (4C) method compared to the laboratory-based method (lab-NCES).Anatomically based matched lesions (41 pairs) in 30 stable vitiligo patients were randomized to receive NCES prepared by 4C method or lab-NCES. Each patient was evaluated at 4, 8, 16 weeks after surgery by a blinded observer with regard to extent of repigmentation, colour match, patient global assessment (PGA) and pattern of repigmentation.Repigmentation outcome in 4C

2018 Journal of the European Academy of Dermatology and Venereology Controlled trial quality: uncertain

90. Association of vitiligo with hospitalization for mental health disorders in US adults. Full Text available with Trip Pro

Association of vitiligo with hospitalization for mental health disorders in US adults. Vitiligo has a complex bidirectional relationship with mental health (MH) disturbances. However, little is known about the relationship between vitiligo and MH emergencies.To examine the associations of vitiligo and MH hospitalizations in the United States.Data from the 2002 to 2012 National Inpatient Sample were analysed, including a ~20% sample of all US hospitalizations (n = 87 053 155 children and adults (...) ). Prevalence of hospitalization for MH disorders, their length of stay (LOS) and cost of care were determined for those with vitiligo compared to those without vitiligo.Hospitalization for MH disorders occurred more commonly in those with vitiligo compared to those without vitiligo (4.17% vs. 2.18%). In multivariable logistic regression models, vitiligo was associated with higher odds of admission for any MH disorder [adjusted odds ratio (95% confidence interval): 1.69 (1.61-1.78)], including 14 of 15 MH

2018 Journal of the European Academy of Dermatology and Venereology

91. Laser Ablation of the Recipient Area With Platelet-Rich Plasma-Enriched Epidermal Suspension Transplant in Vitiligo Surgery: A Pilot Study. (Abstract)

Laser Ablation of the Recipient Area With Platelet-Rich Plasma-Enriched Epidermal Suspension Transplant in Vitiligo Surgery: A Pilot Study. Noncultured epidermal cell suspension transplantation is a very popular surgical modality for treating vitiligo. However, the procedure can be modified to improve results.To study the extent of repigmentation with noncultured trypsinized fragmented epidermal suspension using platelet-rich plasma (PRP) as a suspending agent and pixel erbium yttrium aluminium (...) garnet laser for ablation of recipient area in patients with stable vitiligo.Autologous noncultured tiny epidermal fragments suspended in PRP were grafted on superficially pixel erbium YAG laser-ablated vitiligo lesions in 10 patients. The repigmentation was evaluated over a period of 6 months using a digital image analysis system.Repigmentation was observed as early as 2 weeks after the treatment. Of 20 lesions, 12 (60%) showed excellent response; of which 10 lesions (50%) showed complete

2018 Dermatologic Surgery

92. Addition of oral mini pulse dexamethasone to NBUVB phototherapy and topical steroids helps arrest disease activity in patients with vitiligo. Full Text available with Trip Pro

Addition of oral mini pulse dexamethasone to NBUVB phototherapy and topical steroids helps arrest disease activity in patients with vitiligo. 30188576 2019 01 03 1365-2133 180 1 2019 Jan The British journal of dermatology Br. J. Dermatol. Addition of oral minipulse dexamethasone to narrowband ultraviolet B phototherapy and topical steroids helps arrest disease activity in patients with vitiligo. 193-194 10.1111/bjd.17150 Tovar-Garza A A Department of Dermatology, University of Texas

2018 British Journal of Dermatology

93. Reference method for digital surface measurement of target lesions in vitiligo: a comparative analysis. (Abstract)

Reference method for digital surface measurement of target lesions in vitiligo: a comparative analysis. Objective measurement of target lesions in vitiligo is important for clinical practice and trials, yet no preferred tool has been defined. Reported digital tools have shortcomings related to feasibility aspects and often lack information on validity, reliability and responsiveness. Moreover, studies are not yet based on ultraviolet (UV) photography.To assess the reliability, validity (...) and feasibility of two functions in ImageJ for measurement of target lesions, based on three different types of images including UV pictures.Planimetric measurements were performed on photographs with and without UV, and lesion contours on transparent sheets of 52 vitiligo lesions from 10 patients with vitiligo. The ImageJ functions 'wand' and 'threshold' were used by three and four assessors, respectively. Inter- and intrarater reliability, hypothesis testing for construct validity, and feasibility were

2018 British Journal of Dermatology

94. A Study of ATI-50002 Topical Solution for the Treatment of Vitiligo

A Study of ATI-50002 Topical Solution for the Treatment of Vitiligo A Study of ATI-50002 Topical Solution for the Treatment of Vitiligo - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study of ATI-50002 (...) Topical Solution for the Treatment of Vitiligo The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03468855 Recruitment Status : Active, not recruiting First Posted : March 19, 2018 Last Update Posted : January 8, 2019 Sponsor: Aclaris Therapeutics, Inc. Information provided by (Responsible Party): Aclaris

2018 Clinical Trials

95. Comparison of Surgical Methods on Resistant Sites in Stable Vitiligo Patients

Comparison of Surgical Methods on Resistant Sites in Stable Vitiligo Patients Comparison of Surgical Methods on Resistant Sites in Stable Vitiligo Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Comparison of Surgical Methods on Resistant Sites in Stable Vitiligo Patients The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03717025 Recruitment Status : Recruiting First Posted : October 23, 2018 Last Update Posted

2018 Clinical Trials

96. The Effect of UVB Phototherapy With Microneedling and Circled Needing in Vitiligo Patients

The Effect of UVB Phototherapy With Microneedling and Circled Needing in Vitiligo Patients The Effect of UVB Phototherapy With Microneedling and Circled Needing in Vitiligo Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. The Effect of UVB Phototherapy With Microneedling and Circled Needing in Vitiligo Patients The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03718962 Recruitment Status : Recruiting First Posted

2018 Clinical Trials

97. Comparing Recipient Site Preparation Using Dermabrasion, Dermaroller and Liquid Nitrogen Induced Blister in Non Cultured Epidermal Cell Suspension in Stable Vitiligo

Comparing Recipient Site Preparation Using Dermabrasion, Dermaroller and Liquid Nitrogen Induced Blister in Non Cultured Epidermal Cell Suspension in Stable Vitiligo Comparing Recipient Site Preparation Using Dermabrasion, Dermaroller and Liquid Nitrogen Induced Blister in Non Cultured Epidermal Cell Suspension in Stable Vitiligo - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x (...) × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Comparing Recipient Site Preparation Using Dermabrasion, Dermaroller and Liquid Nitrogen Induced Blister in Non Cultured Epidermal Cell Suspension in Stable Vitiligo The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated

2018 Clinical Trials

98. Habits and Risk Perception Associated with Sun Exposure in Vitiligo Patients according to their participation in a patients' organization. (Abstract)

Habits and Risk Perception Associated with Sun Exposure in Vitiligo Patients according to their participation in a patients' organization. 30284740 2019 03 20 1468-3083 33 3 2019 Mar Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Habits and risk perception associated with sun exposure in vitiligo patients according to their participation in a patients' organization. e100-e103 10.1111/jdv.15264 Bhatia B B Department of Dermatology, Henry Ford (...) Hospital, Detroit, MI, USA. Kechichian E E Department of Dermatology, CHU Henri Mondor, Créteil, France. Eleftheriadou V V Centre of Evidence Based Dermatology, Kings Meadow Campus, University of Nottingham, Nottingham, UK. Castelneau J-P JP Department of Dermatology, CHU Henri Mondor, Créteil, France. Seité S S La Roche-Posay Laboratoire Dermatologique, Paris, France. Meurant J-M JM Association Française du Vitiligo, Paris, France. Hamzavi I I Department of Dermatology, Henry Ford Hospital, Detroit

2018 Journal of the European Academy of Dermatology and Venereology

99. A comparative study between suction blistering graft, mini punch graft and hair follicle transplant in treatment of patients with stable vitiligo. (Abstract)

A comparative study between suction blistering graft, mini punch graft and hair follicle transplant in treatment of patients with stable vitiligo. Vitiligo is an acquired disfiguring common depigmented skin disease.This study aimed to compare the clinical efficacy and safety of suction blistering graft, mini punch and hair follicle techniques in treatment of patients with stable vitiligo.Thirty patients with stable vitiligo were included. Patients were divided into 3 groups, in group (A) 10 (...) patient underwent suction blistering technique, in group (B) 10 patients underwent mini punch technique and in group (C) 10 patients underwent hair follicle technique. Then all patients in the three techniques were subjected to narrow-band ultraviolet B (NB-UVB) phototherapy for 3 months. All patients were assessed by determining the percentage of repigmentation and Dermatology Life Quality Index (DLQI) before and 3 months after the operation.The percentage of repigmentation of vitiligo in suction

2018 Journal of Dermatological Treatment

100. Role of IL-17A receptor blocking in melanocytes survival: A strategic intervention against vitiligo. Full Text available with Trip Pro

Role of IL-17A receptor blocking in melanocytes survival: A strategic intervention against vitiligo. Cytokines regulate immune response and inflammation and play an important role in depigmentation process of an autoimmune disease, vitiligo. We sought to determine how inflammatory cytokines influence the progression of vitiligo, and based on that, we develop a logical therapeutic intervention using primary melanocyte culture. Melanocytes were cultured and exposed to IL-17A, IL-1β, IFN-γ and TGF

2018 Experimental Dermatology

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