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Vitiligo

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81. Views and experiences of seeking information and help for vitiligo: a qualitative study of written accounts. (PubMed)

Views and experiences of seeking information and help for vitiligo: a qualitative study of written accounts. Vitiligo is a relatively common autoimmune condition causing loss of skin pigment. Around 1 in 100 people in the UK develop vitiligo. It can have a significant impact on quality of life for many of those affected. How people access information and help for vitiligo may influence how they manage such impact. We aimed to explore people's views and experiences of seeking health information (...) and help for vitiligo.Qualitative analysis of free-text responses to four open-ended questions in an online survey.Online survey conducted in the UK between February and March 2016.A survey link was emailed to 675 members of The Vitiligo Society, a UK-based charity providing information and support for people with vitiligo. One hundred and sixty-one members responded to the survey (24%).Many participants wrote extensive free text, often reporting frustration with help-seeking. They perceived general

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2018 BMJ open

82. Interventions for Vitiligo. (PubMed)

Interventions for Vitiligo. Which interventions are associated with highest efficacy and fewest adverse events for treating vitiligo?Combination therapies, particularly those involving some form of light (ie, narrowband UV-B) were associated with more improved repigmentation than monotherapies. There was limited evidence to support the association of UV-A alone and UV-B alone with repigmentation for vitiligo. There was moderate evidence to support the association of UV-A and UV-B, when used (...) in combination with psoralens, topical corticosteroids, vitamin D analogues, fluorouracil, azathioprine, and oral prednisolone with improved outcomes for vitiligo. However, combination therapies were associated with more adverse effects.

2016 JAMA

83. The Investigation on the Expression of High Mobility Group Protein Box-1 (HMGB1) in Peripheral Blood of Vitiligo Patients and Healthy Controls According to Clinical Features, Treatment and Disease Activity

The Investigation on the Expression of High Mobility Group Protein Box-1 (HMGB1) in Peripheral Blood of Vitiligo Patients and Healthy Controls According to Clinical Features, Treatment and Disease Activity The Investigation on the Expression of High Mobility Group Protein Box-1 (HMGB1) in Peripheral Blood of Vitiligo Patients and Healthy Controls According to Clinical Features, Treatment and Disease Activity - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers (...) : refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Investigation on the Expression of High Mobility Group Protein Box-1 (HMGB1) in Peripheral Blood of Vitiligo Patients and Healthy Controls According to Clinical Features, Treatment and Disease Activity The safety and scientific validity

2018 Clinical Trials

84. Cutaneous expression of thymic stromal lymphopoietin (TSLP) in vitiligo patients: a case-control study. (PubMed)

Cutaneous expression of thymic stromal lymphopoietin (TSLP) in vitiligo patients: a case-control study. Thymic stromal lymphopoietin (TSLP) is a major pro-allergic cytokine promoting T helper-2 responses. Our aim was to study and verify the hypothesis of the role of TSLP in the pathogenesis of vitiligo.This case-control study was conducted on 25 patients with generalized non-segmental vitiligo (recruited from the Dermatology outpatient clinic, Kasr El Ainy, Faculty of Medicine, Cairo University (...) ) and 25 healthy controls fulfilling the inclusion criteria over a period of 7 months (January 2017-July 2017). Patients underwent complete medical history, detailed assessment of vitiligo, and photographic documentation. Skin biopsies were taken from the back from both patients' vitiliginous skin and from normal skin of controls for which relative TSLP messenger RNA (mRNA) tissue expression levels were measured using quantitative real-time polymerase chain reaction technique.There was a statistically

2018 International Journal of Dermatology

85. Association of human beta-defensin 1 gene polymorphisms with nonsegmental vitiligo. (PubMed)

Association of human beta-defensin 1 gene polymorphisms with nonsegmental vitiligo. Vitiligo is a pigmentation disorder of autoimmune aetiology. Polymorphisms in beta-defensin genes have been linked to a predisposition to some autoimmune disorders.To evaluate the role of polymorphisms in DEFB1, the gene encoding for human beta-defensin (HBD)-1 and its 5' untranslated region in nonsegmental vitiligo.In total, 354 participants [171 patients with non-segmental vitiligo and 183 age and sex-matched (...) healthy controls (HCs)], were genotyped by the PCR-restriction fragment length polymorphism (RFLP) method. For 80 of these individuals (40 patients and -40 HCs) serum HBD-1 was also measured by ELISA.The -44 G allele, CG genotype and GGG haplotype increased the risk for vitiligo (P < 0.02 in all cases), whereas the -20 AA genotype seems to be protective (P = 0.04). Serum HBD-1 levels were lower in patients with vitiligo than in HCs (P < 0.01), as well as in patients with active vitiligo compared

2018 Clinical & Experimental Dermatology

86. Comorbidities in vitiligo: comprehensive review. (PubMed)

Comorbidities in vitiligo: comprehensive review. Vitiligo is a common skin disorder characterized by idiopathic, progressive cutaneous hypomelanosis. Vitiligo is associated with several comorbid autoimmune, systemic, and dermatological diseases, primarily thyroid disease, alopecia areata, diabetes mellitus, pernicious anemia, systemic lupus erythematosus, rheumatoid arthritis, Addison's disease, inflammatory bowel disease, Sjögren's syndrome, dermatomyositis, scleroderma, ocular (...) and audiological abnormalities, psoriasis, and atopic dermatitis. It is essential to increase awareness of these comorbidities in order to improve the disease burden and quality of life of patients with vitiligo. Herein, we review the association with the most frequent comorbidities associated with vitiligo.© 2018 The International Society of Dermatology.

2018 International Journal of Dermatology

87. Vitiligo remitting with tocilizumab. (PubMed)

Vitiligo remitting with tocilizumab. 29888453 2019 01 18 1468-3083 33 1 2019 Jan Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Vitiligo remitting with tocilizumab. e20 10.1111/jdv.15117 Bunker C B CB University College London Hospitals, 250 Euston Road, London, NW1 2AF, UK. Manson J J University College London Hospitals, 250 Euston Road, London, NW1 2AF, UK. eng Letter 2018 06 28 England J Eur Acad Dermatol Venereol 9216037 0926-9959 2018 6

2018 Journal of the European Academy of Dermatology and Venereology

88. Decreased choroidal thickness in vitiligo patients. (PubMed)

Decreased choroidal thickness in vitiligo patients. Vitiligo is a disease characterized by depigmented macules and patches that occur as a result of the loss of functional melanocytes from the affected skin through a mechanism which has not been elucidated yet. Destruction of pigment cells in vitiligo may not remain limited to the skin; the eyelashes, iris, ciliary body, choroid, retinal pigment epithelium and meninges may also be affected. This study aims to compare the choroidal thickness (...) of patients with and without vitiligo using optical coherence tomography (OCT).Spectral-domain optical coherence tomography (SD-OCT) (Retina Scan Advanced RS-3000 NIDEK, Japan) instrument (with λ = 840 nm, 27,000 A-scans/second and 5 μm axial resolution) was used for the imaging. Statistical analysis was performed using SPSS 21.0 software package.In all values except optic nevre area measurements, the choroidal thickness of all vitiligo patients was found out to be thinner compared to the control group.In

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2018 BMC Ophthalmology

89. The early repigmentation pattern of vitiligo is related to the source of melanocytes and by the choice of therapy: a retrospective cohort study. (PubMed)

The early repigmentation pattern of vitiligo is related to the source of melanocytes and by the choice of therapy: a retrospective cohort study. Patients with vitiligo present with different repigmentation patterns in the early recovery stage.To analyze the relationships between early repigmentation patterns in vitiliginous patches, their clinical characteristics, and therapeutic choices.Patients with vitiligo seen in the Department of Dermatology, The First Affiliated Hospital of Nanjing (...) ), progressive stage (P = 0.044), and truncal lesions treated with TVDAs (P < 0.001).The different repigmentation patterns of vitiligo lesions depend on the different source and status of melanocytes and their abilities to produce melanin on the choice of therapy.© 2018 The International Society of Dermatology.

2018 International Journal of Dermatology

90. Efficacy and safety of noncultured melanocyte-keratinocyte transplant procedure for vitiligo and other leukodermas: a critical analysis of the evidence. (PubMed)

Efficacy and safety of noncultured melanocyte-keratinocyte transplant procedure for vitiligo and other leukodermas: a critical analysis of the evidence. Vitiligo is an acquired pigmentary skin of depigmentation occurring secondary to melanocyte destruction. Vitiligo and other leukodermas have a profound impact on quality of life. Current therapies include medical options, such as phototherapy, topical and systemic corticosteroids, topical calcineurin inhibitors, immunomodulators (...) , and antioxidiants, and surgical options. Surgical options provide melanocytic cells to previously depigmented areas and use either tissue grafting or cellular grafting methods. Topical treatments are often insufficient, and many of the current surgical procedures have shown variable response rates. In this review, we discuss the process of the cellular grafting melanocyte-keratinocyte transplantation procedure (MKTP) and critically analyze its efficacy and safety in the treatment of vitiligo and other

2018 International Journal of Dermatology

91. A prospective right-left comparative study to evaluate the efficacy and tolerability of combination of NB-UVB and topical bimatoprost 0.03% eye drops versus NB-UVB given alone in patients of vitiligo vulgaris. (PubMed)

A prospective right-left comparative study to evaluate the efficacy and tolerability of combination of NB-UVB and topical bimatoprost 0.03% eye drops versus NB-UVB given alone in patients of vitiligo vulgaris. 29444382 2018 03 09 1468-3083 2018 Feb 14 Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol A prospective right-left comparative study to evaluate the efficacy and tolerability of combination of NB-UVB and topical bimatoprost 0.03% eye (...) drops versus NB-UVB given alone in patients of vitiligo vulgaris. 10.1111/jdv.14882 Sharma S S Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Parsad D D Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Bhattacharjee R R Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research

2018 Journal of the European Academy of Dermatology and Venereology

92. Once weekly targeted excimer light produced modest re-pigmentation of vitiligo over a 20-week period. (PubMed)

Once weekly targeted excimer light produced modest re-pigmentation of vitiligo over a 20-week period. 29419905 2018 03 05 1468-3083 2018 Feb 08 Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Once weekly targeted excimer light produced modest repigmentation of vitiligo over a 20-week period. 10.1111/jdv.14853 Ayob S S Department of Dermatology, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK. Cockayne S E SE Department of Dermatology, Royal

2018 Journal of the European Academy of Dermatology and Venereology

93. Association of elevated homocysteine levels and Methylenetetrahydrofolate reductase (MTHFR) 1298 A &gt; C polymorphism with Vitiligo susceptibility in Gujarat. (PubMed)

Association of elevated homocysteine levels and Methylenetetrahydrofolate reductase (MTHFR) 1298 A > C polymorphism with Vitiligo susceptibility in Gujarat. Several studies have reported hyperhomocysteinemia in vitiligo patients, suggesting the potential role of elevated homocysteine levels in precipitating vitiligo.We aimed to estimate homocysteine and vitamin B12 levels, and to investigate the role of MTHFR 677 C > T and 1298 A > C polymorphisms in vitiligo susceptibility in Gujarat (...) population.Homocysteine and vitamin B12 levels were estimated in plasma of 55 vitiligo patients and 60 controls by Electrochemiluminescence immunoassay (ECLIA). Polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) and amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) techniques were used to genotype MTHFR 677 C > T and 1298 A > C polymorphisms in 520 vitiligo patients and 558 controls.Our results showed significantly elevated homocysteine levels (p = 0.0003

2018 Journal of dermatological science

94. The role of phototherapy in the surgical treatment of vitiligo: a systematic review. (PubMed)

The role of phototherapy in the surgical treatment of vitiligo: a systematic review. Vitiligo is frequently treated with the combination of phototherapy and melanocyte transplantation. However, the additional benefit of phototherapy is unclear. Moreover, the optimal type and regimen of phototherapy are unknown. The objective of this systematic review was to identify whether phototherapy improves the outcome of melanocyte transplantation in vitiligo. We searched and screened for eligible studies (...) studies confirmed the benefit of phototherapy for melanocyte transplantation. We found no significant differences in repigmentation in studies directly comparing phototherapy modalities. The overall quality of the studies was moderate to poor and high heterogeneity between studies was found. We found limited evidence that phototherapy improves the outcome of melanocyte transplantation in vitiligo. There is insufficient evidence to recommend a specific type or regimen of phototherapy. More studies

2018 Journal of the European Academy of Dermatology and Venereology

95. Comments concerning 'Meta-analysis of the association between vitiligo and the level of superoxide dismutase or malondialdehyde'.

Comments concerning 'Meta-analysis of the association between vitiligo and the level of superoxide dismutase or malondialdehyde'. 29315716 2018 08 07 2018 12 02 1365-2230 43 3 2018 04 Clinical and experimental dermatology Clin. Exp. Dermatol. Comments concerning 'Meta-analysis of the association between vitiligo and the level of superoxide dismutase or malondialdehyde'. 319-320 10.1111/ced.13320 Jouyban A A Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University (...) of Medical Sciences, Tabriz, 51664, Iran. Khoubnasabjafari M M Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, 51664, Iran. eng Letter Comment 2018 01 06 England Clin Exp Dermatol 7606847 0307-6938 4Y8F71G49Q Malondialdehyde EC 1.11.1.6 Catalase EC 1.15.1.1 Superoxide Dismutase IM Clin Exp Dermatol. 2017 Jan;42(1):21-29 27735067 Catalase Humans Hypopigmentation Malondialdehyde Oxidative Stress Superoxide Dismutase Vitiligo 2017 03 31 2018 1 10 6 0 2018 8 8 6

2018 Clinical and experimental dermatology

96. Neural and Endocrinal Pathobiochemistry of Vitiligo: Comparative Study for a Hypothesized Mechanism (PubMed)

Neural and Endocrinal Pathobiochemistry of Vitiligo: Comparative Study for a Hypothesized Mechanism The etiology of vitiligo is still unclear. The aim is to investigate a neural and hormonal etio-pathology of vitiligo. Sixty acrofacial vitiligo patients were divided into two subgroups as active vitiligo patients group (AVPs; n = 35) and stable vitiligo patients group (SVP; n = 25). Forty healthy subjects without any systemic or dermatological disease were used as controls. Blood samples were (...) . There was a significant decrease in serum level of ACTH in either AVP or SVP than control and in AVP than SVP group. In conclusion, there are some neural and endocrine markers that play a pivotal role in pathogenesis and/or consequences of vitiligo. The abnormally disturbed levels of theses markers lead to melanocyte destruction and/or depigmentation.

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2018 Frontiers in endocrinology

97. Plasma & urinary catecholamines & urinary vanillylmandelic acid levels in patients with generalized vitiligo (PubMed)

Plasma & urinary catecholamines & urinary vanillylmandelic acid levels in patients with generalized vitiligo Vitiligo is an acquired skin disease characterized by depigmented areas of the skin. Increased release of catecholamines from autonomic nerve endings in microenvironment of melanocytes in affected skin might be involved in the aetiopathogenesis of vitiligo. Levels of catecholamines are considered as being related to onset or worsening of the disease. Therefore, in this study, the role (...) of catecholamines was evaluated in mapping disease stability and outcome of vitiligo patients undergoing melanocyte transfer.In this study, circulatory and urinary levels of catecholamine (CA) and vanillylmandelic acid (VMA) were determined in 45 individuals (30 vitiligo patients and 15 healthy controls) using ELISA.A significant increase for plasma and urinary catecholamines along with VMA was observed as compared to healthy controls. When the pre- and post-intervention levels were analyzed in responders

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2018 The Indian journal of medical research

98. Prostaglandin F2-alpha (PGF2α) in Vitiligo

Prostaglandin F2-alpha (PGF2α) in Vitiligo Prostaglandin F2-alpha (PGF2α) in Vitiligo - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Prostaglandin F2-alpha (PGF2α) in Vitiligo The safety and scientific (...) Fathy Elmasry, Cairo University Study Details Study Description Go to Brief Summary: study the cutaneous expression of PGF2α in vitiligo patients and compare it with normal control subjects. Condition or disease Intervention/treatment Phase Vitiligo Other: Skin biopsy Not Applicable Detailed Description: Measurement of tissue levels of PGF2α in vitiligo patients and compare them with healthy controls. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial

2018 Clinical Trials

99. CAPN3, DCT, MLANA and TYRP1 are overexpressed in skin of vitiligo vulgaris Mexican patients (PubMed)

CAPN3, DCT, MLANA and TYRP1 are overexpressed in skin of vitiligo vulgaris Mexican patients Vitiligo is a disorder causing skin depigmentation, in which several factors have been proposed for its pathogenesis: Environmental, genetic and biological aspects of melanocytes, even those of the surrounding keratinocytes. However, the lack of understanding of the mechanisms has complicated the task of predicting the development and progression. The present study used microarray analysis (...) to characterize the transcriptional profile of skin from Vitiligo Vulgaris (VV) patients and the identified transcripts were validated using targeted high-throughput RNA sequencing in a broader set of patients. For microarrays, mRNA was taken from 20 skin biopsies of 10 patients with VV (pigmented and depigmented skin biopsy of each), and 5 biopsies of healthy subjects matched for age and sex were used as a control. A signature was identified that contains the expression pattern of 722 genes between

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2018 Experimental and therapeutic medicine

100. PD-L1 reverses depigmentation in Pmel-1 vitiligo mice by increasing the abundance of Tregs in the skin (PubMed)

PD-L1 reverses depigmentation in Pmel-1 vitiligo mice by increasing the abundance of Tregs in the skin Programmed cell death 1 ligand 1 (PD-L1) is a ligand of programmed cell death 1 (PD-1) that functions as an immune checkpoint by down-regulating immune responses. To determine whether PD-L1 is a therapy target in vitiligo treatment, Pmel-1 vitiligo mice were treated with a PD-L1 fusion protein. Treatment with this fusion protein significantly reversed/suppressed depigmentation development (...) in adult Pmel-1 mice. Mechanistically, enrichment of regulatory T cells (Treg) in the skin was detected after PD-L1 fusion protein treatment in Pmel-1 mice. Furthermore, Tregs abundance was also increased in both the spleen and circulation of Pmel-1 mice treated with PD-L1. These data indicate that PD-L1 protein therapy inhibits the immune response and reverses depigmentation development in Pmel-1 vitiligo mice.

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2018 Scientific reports

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