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Vitiligo

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81. Once weekly targeted excimer light produced modest re-pigmentation of vitiligo over a 20-week period. (PubMed)

Once weekly targeted excimer light produced modest re-pigmentation of vitiligo over a 20-week period. 29419905 2018 03 05 1468-3083 2018 Feb 08 Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Once weekly targeted excimer light produced modest repigmentation of vitiligo over a 20-week period. 10.1111/jdv.14853 Ayob S S Department of Dermatology, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK. Cockayne S E SE Department of Dermatology, Royal

2018 Journal of the European Academy of Dermatology and Venereology

82. Combination of Follicular and Epidermal Cell Suspension as a Novel Surgical Approach in Difficult-to-Treat Vitiligo: A Randomized Clinical Trial. (PubMed)

Combination of Follicular and Epidermal Cell Suspension as a Novel Surgical Approach in Difficult-to-Treat Vitiligo: A Randomized Clinical Trial. Epidermal cell suspension (ECS) and follicular cell suspension (FCS) are successful surgical modalities for the treatment of stable vitiligo. However, repigmentation in generalized and acrofacial vitiligo and over acral or bony sites (eg, elbows, knees, iliac crests, and malleoli), which are difficult to treat, is challenging.To study the efficacy (...) of transplanting a combination of autologous, noncultured ECS and FCS (ECS + FCS) compared with ECS alone in stable vitiligo.A prospective, observer-blinded, active-controlled, randomized clinical trial was conducted at a tertiary care hospital, with treatment administered as an outpatient procedure. Thirty participants who had stable vitiligo with symmetrical lesions were recruited between October 18, 2013, and October 28, 2016. All of the lesions were resistant to medical modalities with minimum lesional

2018 JAMA dermatology (Chicago, Ill.)

83. Association of elevated homocysteine levels and Methylenetetrahydrofolate reductase (MTHFR) 1298 A > C polymorphism with Vitiligo susceptibility in Gujarat. (PubMed)

Association of elevated homocysteine levels and Methylenetetrahydrofolate reductase (MTHFR) 1298 A > C polymorphism with Vitiligo susceptibility in Gujarat. Several studies have reported hyperhomocysteinemia in vitiligo patients, suggesting the potential role of elevated homocysteine levels in precipitating vitiligo.We aimed to estimate homocysteine and vitamin B12 levels, and to investigate the role of MTHFR 677 C > T and 1298 A > C polymorphisms in vitiligo susceptibility in Gujarat (...) population.Homocysteine and vitamin B12 levels were estimated in plasma of 55 vitiligo patients and 60 controls by Electrochemiluminescence immunoassay (ECLIA). Polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) and amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) techniques were used to genotype MTHFR 677 C > T and 1298 A > C polymorphisms in 520 vitiligo patients and 558 controls.Our results showed significantly elevated homocysteine levels (p = 0.0003

2018 Journal of dermatological science

84. The role of phototherapy in the surgical treatment of vitiligo: a systematic review. (PubMed)

The role of phototherapy in the surgical treatment of vitiligo: a systematic review. Vitiligo is frequently treated with the combination of phototherapy and melanocyte transplantation. However, the additional benefit of phototherapy is unclear. Moreover, the optimal type and regimen of phototherapy are unknown. The objective of this systematic review was to identify whether phototherapy improves the outcome of melanocyte transplantation in vitiligo. We searched and screened for eligible studies (...) studies confirmed the benefit of phototherapy for melanocyte transplantation. We found no significant differences in repigmentation in studies directly comparing phototherapy modalities. The overall quality of the studies was moderate to poor and high heterogeneity between studies was found. We found limited evidence that phototherapy improves the outcome of melanocyte transplantation in vitiligo. There is insufficient evidence to recommend a specific type or regimen of phototherapy. More studies

2018 Journal of the European Academy of Dermatology and Venereology

85. Comments concerning 'Meta-analysis of the association between vitiligo and the level of superoxide dismutase or malondialdehyde'.

Comments concerning 'Meta-analysis of the association between vitiligo and the level of superoxide dismutase or malondialdehyde'. 29315716 2018 08 07 2018 12 02 1365-2230 43 3 2018 04 Clinical and experimental dermatology Clin. Exp. Dermatol. Comments concerning 'Meta-analysis of the association between vitiligo and the level of superoxide dismutase or malondialdehyde'. 319-320 10.1111/ced.13320 Jouyban A A Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University (...) of Medical Sciences, Tabriz, 51664, Iran. Khoubnasabjafari M M Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, 51664, Iran. eng Letter Comment 2018 01 06 England Clin Exp Dermatol 7606847 0307-6938 4Y8F71G49Q Malondialdehyde EC 1.11.1.6 Catalase EC 1.15.1.1 Superoxide Dismutase IM Clin Exp Dermatol. 2017 Jan;42(1):21-29 27735067 Catalase Humans Hypopigmentation Malondialdehyde Oxidative Stress Superoxide Dismutase Vitiligo 2017 03 31 2018 1 10 6 0 2018 8 8 6

2018 Clinical and experimental dermatology

86. Neural and Endocrinal Pathobiochemistry of Vitiligo: Comparative Study for a Hypothesized Mechanism (PubMed)

Neural and Endocrinal Pathobiochemistry of Vitiligo: Comparative Study for a Hypothesized Mechanism The etiology of vitiligo is still unclear. The aim is to investigate a neural and hormonal etio-pathology of vitiligo. Sixty acrofacial vitiligo patients were divided into two subgroups as active vitiligo patients group (AVPs; n = 35) and stable vitiligo patients group (SVP; n = 25). Forty healthy subjects without any systemic or dermatological disease were used as controls. Blood samples were (...) . There was a significant decrease in serum level of ACTH in either AVP or SVP than control and in AVP than SVP group. In conclusion, there are some neural and endocrine markers that play a pivotal role in pathogenesis and/or consequences of vitiligo. The abnormally disturbed levels of theses markers lead to melanocyte destruction and/or depigmentation.

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2018 Frontiers in endocrinology

87. Plasma & urinary catecholamines & urinary vanillylmandelic acid levels in patients with generalized vitiligo (PubMed)

Plasma & urinary catecholamines & urinary vanillylmandelic acid levels in patients with generalized vitiligo Vitiligo is an acquired skin disease characterized by depigmented areas of the skin. Increased release of catecholamines from autonomic nerve endings in microenvironment of melanocytes in affected skin might be involved in the aetiopathogenesis of vitiligo. Levels of catecholamines are considered as being related to onset or worsening of the disease. Therefore, in this study, the role (...) of catecholamines was evaluated in mapping disease stability and outcome of vitiligo patients undergoing melanocyte transfer.In this study, circulatory and urinary levels of catecholamine (CA) and vanillylmandelic acid (VMA) were determined in 45 individuals (30 vitiligo patients and 15 healthy controls) using ELISA.A significant increase for plasma and urinary catecholamines along with VMA was observed as compared to healthy controls. When the pre- and post-intervention levels were analyzed in responders

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2018 The Indian journal of medical research

88. Prostaglandin F2-alpha (PGF2α) in Vitiligo

Prostaglandin F2-alpha (PGF2α) in Vitiligo Prostaglandin F2-alpha (PGF2α) in Vitiligo - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Prostaglandin F2-alpha (PGF2α) in Vitiligo The safety and scientific (...) Fathy Elmasry, Cairo University Study Details Study Description Go to Brief Summary: study the cutaneous expression of PGF2α in vitiligo patients and compare it with normal control subjects. Condition or disease Intervention/treatment Phase Vitiligo Other: Skin biopsy Not Applicable Detailed Description: Measurement of tissue levels of PGF2α in vitiligo patients and compare them with healthy controls. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial

2018 Clinical Trials

89. CAPN3, DCT, MLANA and TYRP1 are overexpressed in skin of vitiligo vulgaris Mexican patients (PubMed)

CAPN3, DCT, MLANA and TYRP1 are overexpressed in skin of vitiligo vulgaris Mexican patients Vitiligo is a disorder causing skin depigmentation, in which several factors have been proposed for its pathogenesis: Environmental, genetic and biological aspects of melanocytes, even those of the surrounding keratinocytes. However, the lack of understanding of the mechanisms has complicated the task of predicting the development and progression. The present study used microarray analysis (...) to characterize the transcriptional profile of skin from Vitiligo Vulgaris (VV) patients and the identified transcripts were validated using targeted high-throughput RNA sequencing in a broader set of patients. For microarrays, mRNA was taken from 20 skin biopsies of 10 patients with VV (pigmented and depigmented skin biopsy of each), and 5 biopsies of healthy subjects matched for age and sex were used as a control. A signature was identified that contains the expression pattern of 722 genes between

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2018 Experimental and therapeutic medicine

90. PD-L1 reverses depigmentation in Pmel-1 vitiligo mice by increasing the abundance of Tregs in the skin (PubMed)

PD-L1 reverses depigmentation in Pmel-1 vitiligo mice by increasing the abundance of Tregs in the skin Programmed cell death 1 ligand 1 (PD-L1) is a ligand of programmed cell death 1 (PD-1) that functions as an immune checkpoint by down-regulating immune responses. To determine whether PD-L1 is a therapy target in vitiligo treatment, Pmel-1 vitiligo mice were treated with a PD-L1 fusion protein. Treatment with this fusion protein significantly reversed/suppressed depigmentation development (...) in adult Pmel-1 mice. Mechanistically, enrichment of regulatory T cells (Treg) in the skin was detected after PD-L1 fusion protein treatment in Pmel-1 mice. Furthermore, Tregs abundance was also increased in both the spleen and circulation of Pmel-1 mice treated with PD-L1. These data indicate that PD-L1 protein therapy inhibits the immune response and reverses depigmentation development in Pmel-1 vitiligo mice.

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2018 Scientific reports

91. Vitiligo immune reconstitution inflammatory syndrome (IRIS)—An incidental finding in a tertiary teaching hospital in southeast Nigeria (PubMed)

Vitiligo immune reconstitution inflammatory syndrome (IRIS)—An incidental finding in a tertiary teaching hospital in southeast Nigeria 29387768 2019 02 26 2352-5126 4 2 2018 Mar JAAD case reports JAAD Case Rep Vitiligo immune reconstitution inflammatory syndrome (IRIS)-An incidental finding in a tertiary teaching hospital in southeast Nigeria. 145-148 10.1016/j.jdcr.2017.09.030 Onyekonwu Chinwe Laura CL Sub-Department of Dermatology, College of Medicine, University of Nigeria, Ituku-Ozalla (...) HIV IRIS, immune reconstitution inflammatory syndrome highly active antiretroviral therapy immune reconstitution inflammatory syndrome vitiligo 2018 2 2 6 0 2018 2 2 6 0 2018 2 2 6 1 epublish 29387768 10.1016/j.jdcr.2017.09.030 S2352-5126(17)30239-4 PMC5789520 Curr Opin HIV AIDS. 2010 Nov;5(6):504-10 20966640 J Acquir Immune Defic Syndr. 1989;2(4):382-8 2666640 Indian J Dermatol. 2014 Mar;59(2):209 24700956 Arch Dermatol. 1991 Sep;127(9):1383-91 1892408 Int J STD AIDS. 2007 Feb;18(2):138-9

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2018 JAAD Case Reports

92. Clinical and Molecular Aspects of Vitiligo Treatments (PubMed)

Clinical and Molecular Aspects of Vitiligo Treatments Vitiligo is an asymptomatic but cosmetically disfiguring disorder that results in the formation of depigmented patches on skin and/or mucosae. Vitiligo can be segmental or non-segmental depending upon the morphology of the clinical involvement. It can also be classified as progressing or stable based on the activity of the disease. Further, the extent of involvement can be limited (localized disease) or extensive (generalized disease (...) ). The treatment of vitiligo therefore depends on the clinical classification/characteristics of the disease and usually comprises of 2 strategies. The first involves arresting the progression of active disease (to provide stability) in order to limit the area involved by depigmentation. The second strategy aims at repigmentation of the depigmented area. It is also important to maintain the disease in a stable phase and to prevent relapse. Accordingly, a holistic treatment approach for vitiligo should

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2018 International journal of molecular sciences

93. Association rare: lichen scléroatrophique extragénital et vitiligo inflammatoire chez un enfant (PubMed)

Association rare: lichen scléroatrophique extragénital et vitiligo inflammatoire chez un enfant Scleroatrophic lichen (SL) and vitiligo are two depigmenting disorders which may occur separately or, rarely, in combination. Their association may seem logical because both these disorders are characterized by the suspicion of an autoimmune pathogenesis. We here report the case of a 8-year old girl, with no notable medical history, presenting with achromic macules and papular nonpruritic lesions (...) face of the knees. Two biopsies were performed. Histological examination of an achromic macula showed vitiligo with inflammatory reaction while histological examination of an infiltrated lesion allowed the diagnosis of scleroatrophic lichen. Significant clinical improvement was obtained by local treatment with dermocorticoids. Therefore, this pathological association between scleroatrophic lichen and vitiligo in our patient, highlights the key role of epidermal lichenoid inflammatory process

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2018 The Pan African medical journal

94. Two reports of malignant melanoma arising within a new vitiligo-like depigmented patch (PubMed)

Two reports of malignant melanoma arising within a new vitiligo-like depigmented patch 29998177 2019 02 26 2352-5126 4 6 2018 Jul JAAD case reports JAAD Case Rep Two reports of malignant melanoma arising within a new vitiligo-like depigmented patch. 573-575 10.1016/j.jdcr.2018.05.008 Francisco Gina G Department of Dermatology, Rutgers-Robert Wood Johnson Medical School, Somerset, New Jersey. Rao Babar K BK Department of Dermatology, Rutgers-Robert Wood Johnson Medical School, Somerset, New

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2018 JAAD Case Reports

95. Nivolumab induced vitiligo-like lesions in a patient with metastatic squamous cell carcinoma of the lung (PubMed)

Nivolumab induced vitiligo-like lesions in a patient with metastatic squamous cell carcinoma of the lung 30069410 2019 02 26 2072-1439 10 6 2018 Jun Journal of thoracic disease J Thorac Dis Nivolumab induced vitiligo-like lesions in a patient with metastatic squamous cell carcinoma of the lung. E481-E484 10.21037/jtd.2018.05.104 Nishino Kazumi K Department of Thoracic Oncology, Osaka International Cancer Institute, Osaka, Japan. Ohe Shuichi S Department of Dermatological Oncology, Osaka

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2018 Journal of thoracic disease

96. Porphyria Cutanea Tarda Presenting with Scleroderma, Ichthyosis, Alopecia, and Vitiligo (PubMed)

Porphyria Cutanea Tarda Presenting with Scleroderma, Ichthyosis, Alopecia, and Vitiligo Porphyria cutanea tarda (PCT) is a cutaneous porphyria that presents later in life with cutaneous findings in sun-exposed sites. We report a complex case of PCT in a 67-year-old woman with an unusual constellation of cutaneous findings: scleroderma, acquired ichthyosis, and nonscarring alopecia. Possible triggers for her PCT include tamoxifen treatment for breast cancer and carrier status (...) of the hemochromatosis gene. High-dose chloroquine was used to successfully achieve clinical remission and normalize her uroporphyrins. While on chloroquine she developed extensive classic vitiligo. It is not clear if this is another feature of her complex and unusual PCT, or a consequence of her antimalarial therapy.

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2018 Case reports in dermatology

97. Association of PTPN22 gene polymorphism with non-segmental vitiligo in South Indian Tamils (PubMed)

Association of PTPN22 gene polymorphism with non-segmental vitiligo in South Indian Tamils Non-segmental vitiligo (NSV) is a depigmentation skin disease with loss of melanocytes in the skin.To evaluate whether the protein tyrosine phosphatase non-receptor type (PTPN22) single nucleotide polymorphism at +1858C/T had any association with non-segmental vitiligo in South Indian Tamils.Genomic DNA was extracted using the phenol-chloroform method, and PTPN22 +1858C/T polymorphism was assayed (...) by Taqman 5'allele discrimination assay. Protein levels were quantified by ELISA.We found that the allelic frequency of variants of PTPN22 (rs2476601) were significantly different between controls and cases showing a vitiligo risk in the South Indian Tamil population. PTPN22 levels were higher in the heterozygous CT genotype in NSV, when compared with that of the major variant CC genotype of rs2476601.This study suggests that the heterozygous CT genotype, of the PTPN22 SNP rs2476601, has a strong risk

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2018 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

98. Malformation de la charnière cervico-occipitale et vitiligo (PubMed)

Malformation de la charnière cervico-occipitale et vitiligo Vitiligo is a relatively common multifactorial polygenetic dermatosis (0.5%-2% of general population) characterized by segmental or nonsegmental cutaneous depigmentation. Chiari malformation is a congenital cervico-occipital junction disease characterized by a migration of a part of the cerebellum through the foramen magnum.The association between these two pathologies is exceptional and poses a cause-effect problem. We here report (...) ). The patient underwent osteo-dural decompression of the posterior fossa with good neurological improvement and repigmentation of patches after 6 months. A few cases have been reported in the literature that show this association. Arguments in favor are: localization of lesions in dermatomes in correspondence with the malformation and regression after surgery. Etiopathogenesis of vitiligo is not clear, then several theories have been proposed to explain its occurrence;autoimmune theory, epidermal adhesion

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2018 The Pan African medical journal

99. HO‐1 regulates the function of Treg: Association with the immune intolerance in vitiligo (PubMed)

HO‐1 regulates the function of Treg: Association with the immune intolerance in vitiligo In vitiligo, cutaneous depigmentation is accompanied by increased T cell cytolytic activity targeting melanocytes, indicating that autoimmune tolerance is disrupted. The inhibited amount and function of Tregs have been indicated to be involved in the autoimmune intolerance in vitiligo, however, with the conclusion still controversial and the involved mechanism unknown. In this study, we explored (...) the molecular and cellular alterations accounting for the impaired Treg response in vitiligo. Our results showed that the amount of Tregs was drastically reduced in peripheral blood of active vitiligo patients. Furthermore, the immunoregulatory function of Tregs was attenuated, with lower expression of CTLA4, IL-10 and TGF-β. Moreover, the expression of HO-1, a functional modulator of Tregs, was decreased in vitiligo Tregs, and the concentrations of HO-1 metabolites, including bilirubin, CoHb and iron, were

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2018 Journal of cellular and molecular medicine

100. Metabolic Syndrome in Early Onset Versus Late Onset Vitiligo

Metabolic Syndrome in Early Onset Versus Late Onset Vitiligo Metabolic Syndrome in Early Onset Versus Late Onset Vitiligo - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Metabolic Syndrome in Early Onset (...) Versus Late Onset Vitiligo The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03622320 Recruitment Status : Recruiting First Posted : August 9, 2018 Last Update Posted : August 9, 2018 See Sponsor: Cairo University

2018 Clinical Trials

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