How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

3,464 results for

Vitiligo

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

21. Association study between vitiligo and autoimmune-related genes CYP27B1, REL, TNFAIP3, IL2 and IL21. (Abstract)

Association study between vitiligo and autoimmune-related genes CYP27B1, REL, TNFAIP3, IL2 and IL21. The aetiology of vitiligo has not been fully elucidated, and several hypotheses have been investigated; among them, the most explored assumes an autoimmune basis for the disease. Supporting this hypothesis is the frequent co-occurrence of autoimmune diseases with vitiligo. In addition, various genetic loci associated with vitiligo harbour key immune response genes. Our general hypothesis (...) is that autoimmunity-associated genes participate in the control of vitiligo susceptibility. To investigate this hypothesis, we tested for association between vitiligo and genes CYP27B1, REL, TNFAIP3 and IL2/IL21, all previously related to autoimmune diseases associated with vitiligo. The study was performed using two independent population samples: a family-based discovery set (211 trios) and a replication set (131 cases/119 controls). Statistically significant association with vitiligo was detected between

2020 Experimental Dermatology

22. Aberrant ETS-1 signalling impedes the expression of cell adhesion molecules and matrix metalloproteinases in non-segmental vitiligo. (Abstract)

Aberrant ETS-1 signalling impedes the expression of cell adhesion molecules and matrix metalloproteinases in non-segmental vitiligo. Cell adhesion is a complex process that involves multiple molecules on the cell surface (ie cell adhesion molecules [CAMs]), surrounding cells and extracellular matrix (ECM). Repigmentation in vitiligo is dependent on the ECM remodelling and cellular migration, primarily attributed to the transcriptional activation of matrix metalloproteinases (MMPs (...) ). In this study, we aimed to demonstrate the role of ETS-1 signalling in the regulation of MMPs and CAMs. Therefore, we studied the expression of ETS-1, MMPs (MMP-2, MMP-9) and CAMs including E-cadherin, ITGA-1 and ICAM-1 in vitiligo (both active and stable) ex vivo. Further, we compared melanocyte morphology and their adhesion towards collagen IV and laminin between control and vitiligo groups in vitro. Also, we silenced ETS-1 in melanocytes cultured from control skin and observed post-silencing effect

2020 Experimental Dermatology

23. Near-infrared spectroscopy as a potential non-invasive tool in the assessment of disease activity in vitiligo patients. (Abstract)

Near-infrared spectroscopy as a potential non-invasive tool in the assessment of disease activity in vitiligo patients. Vitiligo is a common chronic depigmenting skin disease. We explored the utility of near-infrared (NIR) spectroscopy in the identification of spectral changes associated with disease activity in vitiligo patients. In vivo spectral measurements were performed directly on the perilesional skin of 70 vitiligo patients. Relative intensities (second derivative) at 1139, 1344, 1646 (...) and 1839 nm appeared to be significantly lower in the perilesional region of patients with active vitiligo compared with stable disease, while the intensity at 1884 nm seemed to be significantly higher. A classification model based on the spectral ranges around those peaks generated a correct prediction in 82.9% of the cases. In conclusion, we can state that NIR spectroscopy could have potential in the assessment of disease activity. However, large-scale prospective studies are necessary to confirm our

2020 Experimental Dermatology

24. Fas-FasL interaction in cytotoxic T cell-mediated vitiligo: The role of lesional expression of tumor necrosis factor-α and interferon-γ in Fas-mediated melanocyte apoptosis. (Abstract)

Fas-FasL interaction in cytotoxic T cell-mediated vitiligo: The role of lesional expression of tumor necrosis factor-α and interferon-γ in Fas-mediated melanocyte apoptosis. Vitiligo is an acquired skin depigmentation disorder resulting from the selective loss of epidermal melanocytes, and previous studies have suggested that a T lymphocyte-mediated mechanism has a role in melanocyte loss. Although Fas-Fas ligand (FasL) interactions are important for T lymphocytes to mediate cytotoxicity (...) , there are only few reports examining the involvement of the Fas-FasL pathway in vitiligo using in vivo mouse models. In addition, there have been no reports concerning Fas-mediated apoptosis in human melanocytes in vitro. In this study, we found that the Fas-mediated pathway is involved in cytotoxic T lymphocyte (CTL)-dependent vitiligo in a mouse model and FasL-induced apoptosis of human melanocytes. Tumor necrosis factor (TNF)-α and interferon (IFN)-γ, the expression levels of which have been reported

2020 Experimental Dermatology

25. Expression of immune checkpoints in active nonsegmental vitiligo: a pilot study. (Abstract)

Expression of immune checkpoints in active nonsegmental vitiligo: a pilot study. Vitiligo is a depigmentary skin disfigurement resulting from destruction of melanocytes caused by a possible malfunctioning immunity. This destruction could be linked to an aberrant T-cell-mediated immune response. Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) and programmed death-1 (PD-1) are immune checkpoints capable of downregulating T-cell immune functions.To evaluate the pattern of expression of PD-1 (...) and CTLA-4 in active vitiligo skin.Thirty nonsegmental vitiligo (NSV) patients had been included in this pilot study. Marginal, lesional, and nonlesional skin biopsies were obtained. PD-1 and CTLA-4 immunohistochemistry expression in the mononuclear inflammatory infiltrates were evaluated using digital images.The marginal and lesional inflammatory infiltrates were significantly abundant when compared to nonlesional ones. The marginal infiltrates were significantly abundant when compared to the lesional

2020 International Journal of Dermatology

26. A prospective study to assess the efficacy of various surgical modalities in treatment of stable vitiligo patches over resistant sites. (Abstract)

A prospective study to assess the efficacy of various surgical modalities in treatment of stable vitiligo patches over resistant sites. Despite advances in surgical management of vitiligo, lesions on acral areas and bony prominences remain treatment refractory. There is lack of literature on the treatment efficacy of various surgical modalities over these treatment refractory sites.To compare the efficacy of three common methods of grafting in vitiligo in known resistant areas.A single-center (...) interventional clinical trial involving 30 patients of stable vitiligo (disease stability ≥1 year) located over bony prominences and acral areas. All patients were treated with noncultured epidermal cell suspension (NCES), suction blister epidermal grafting (SBEG), and mini punch grafting (MPG) on three separate patches. Extent of repigmentation was assessed at 12 and 24 weeks, color matching and patient satisfaction were evaluated at 24 weeks.Among 30 participants, 22 (73%) were females, mean age was 27.4

2020 International Journal of Dermatology

27. Family Clustering of Autoimmune Vitiligo Results Principally from Polygenic Inheritance of Common Risk Alleles. Full Text available with Trip Pro

Family Clustering of Autoimmune Vitiligo Results Principally from Polygenic Inheritance of Common Risk Alleles. Vitiligo is an autoimmune disease that results in patches of depigmented skin and hair. Previous genome-wide association studies (GWASs) of vitiligo have identified 50 susceptibility loci. Variants at the associated loci are generally common and have individually small effects on risk. Most vitiligo cases are "simplex," where there is no family history of vitiligo, though occasional (...) family clustering of vitiligo occurs, and some "multiplex" families report numerous close affected relatives. Here, we investigate whether simplex and multiplex vitiligo comprise different disease subtypes with different underlying genetic etiologies. We developed and compared the performance of several different vitiligo polygenic risk scores derived from GWAS data. By using the best-performing risk score, we find increased polygenic burden of risk alleles identified by GWAS in multiplex vitiligo

2019 American Journal of Human Genetics

28. The effectiveness of combination therapy with 308-nm excimer laser in vitiligo in Han Chinese People. Full Text available with Trip Pro

The effectiveness of combination therapy with 308-nm excimer laser in vitiligo in Han Chinese People. 29974452 2019 07 02 2019 07 02 1440-0960 60 1 2019 Feb The Australasian journal of dermatology Australas. J. Dermatol. The effectiveness of combination therapy with 308-nm excimer laser in vitiligo in Han Chinese People. e85-e86 10.1111/ajd.12883 Li Lili L http://orcid.org/0000-0002-9662-287X Department of Dermatology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China. Hong (...) & derivatives therapeutic use Calcineurin Inhibitors therapeutic use Combined Modality Therapy Dermatologic Agents therapeutic use Female Humans Lasers, Excimer therapeutic use Low-Level Light Therapy Male Middle Aged Skin Pigmentation Tacrolimus therapeutic use Vitiligo drug therapy radiotherapy 2018 7 6 6 0 2019 7 3 6 0 2018 7 6 6 0 ppublish 29974452 10.1111/ajd.12883

2019 The Australasian journal of dermatology Controlled trial quality: uncertain

29. Oxidative stress-induced HMGB1 release from melanocytes: a paracrine mechanism underlying the cutaneous inflammation in vitiligo. (Abstract)

Oxidative stress-induced HMGB1 release from melanocytes: a paracrine mechanism underlying the cutaneous inflammation in vitiligo. Vitiligo is a cutaneous depigmentation disorder caused by the destruction of epidermal melanocytes. The generation and the skin infiltration of autoreactive CD8+ cytotoxic T cells triggered by oxidative stress play a critical role in vitiligo. High-mobility group protein B1 (HMGB1) is a classic damage-associated molecular pattern (DAMP) molecule with strong (...) proinflammatory effects in inflammatory reactions. A previous study had reported an enhanced expression of HMGB1 in vitiligo lesion, but the role of HMGB1 in cutaneous inflammation of vitiligo was still unknown. In the present study, we initially found that HMGB1 was released from the nucleus of melanocytes in vitiligo perilesional skin. Furthermore, cultured normal human melanocytes (NHMs) could release HMGB1 under the treatment with hydrogen peroxide. Moreover, HMGB1 facilitated the secretion of CXCL16

2019 Journal of Investigative Dermatology

30. UV light set-ups for vitiligo photography, a comparative study on image quality and ease of use. Full Text available with Trip Pro

UV light set-ups for vitiligo photography, a comparative study on image quality and ease of use. Ultraviolet (UV) light is an essential tool to assess the extent, spreading and staging of vitiligo. Different UV light set-ups are used for vitiligo photography, including the following: (i) hand-held Wood's lamps; (ii) soft boxes with UV lamps; (iii) UV flash attached to the camera; and (iv) high output UV flash.Our objective was to compare UV light set-ups for vitiligo photography regarding image (...) quality and ease of use.Patients with vitiligo lesions with unclear borders were included. Two images were made with all four UV set-ups per patient, for a large and a small area. Image quality was scored separately by three blinded vitiligo experts on five criteria: overall quality, clearness of borders, contrast and sharpness and for larger areas the shadows. The two professional medical photographers were asked to score the ease of use for each set-up.A total of 88 photos were assessed from 11

2019 Journal of the European Academy of Dermatology and Venereology

31. Harnessing the Power of Regenerative Therapy for Vitiligo and Alopecia Areata. Full Text available with Trip Pro

Harnessing the Power of Regenerative Therapy for Vitiligo and Alopecia Areata. Vitiligo and alopecia areata (AA) are common autoimmune conditions characterized by white spots on the skin (vitiligo) and bald spots on the scalp (AA), which significantly impact patients' lives by damaging their appearance and function. Melanocytes are the target of immune destruction in vitiligo and are hypothesized to be the site of immune attack in AA. This inflammatory process can be partially reversed (...) by immunosuppressive drugs. Both conditions demonstrate regenerative components that are just now being identified. In this review, we focus on the regenerative medicine aspects of vitiligo and AA, using experimental data from human, mouse, and in vitro models, summarizing the key pathways involved in repopulation of the epidermis with melanocytes in vitiligo and in regrowth of hair follicles in AA. We also discuss treatments that may activate these pathways. Of the regenerative treatments, JAK inhibitors

2019 Journal of Investigative Dermatology

32. Catalase but not vitamin D receptor gene polymorphisms are associated with nonsegmental vitiligo in Northwestern Mexicans. (Abstract)

Catalase but not vitamin D receptor gene polymorphisms are associated with nonsegmental vitiligo in Northwestern Mexicans. Vitiligo is an acquired pigmentation disorder characterized by melanocyte loss via autoimmune mechanisms triggered by oxidative stress. Gene polymorphisms in antioxidant enzymes and immunomodulators such as catalase (CAT) and vitamin D receptor (VDR), respectively, have been linked to vitiligo in European and Asian populations. Our aim was to evaluate the role of CAT (...) and VDR gene polymorphisms as well as CAT and vitamin D in nonsegmental vitiligo in Northwestern Mexicans.A total of 357 subjects, 173 nonsegmental vitiligo patients and 184 age-gender matched healthy controls, were genotyped by PCR-restriction fragment length polymorphism. CAT activity was determined in 39 patients and in 39 controls and vitamin D (VitD) levels in 35 individuals per group.CAT 419 C/T gene polymorphism was not informative, -89 A/T was associated with risk (P = 0.02), and 389 C/T

2019 International Journal of Dermatology

33. Treatment responses in patients with vitiligo to very potent topical corticosteroids combined with vitaminotherapy in Madagascar. (Abstract)

Treatment responses in patients with vitiligo to very potent topical corticosteroids combined with vitaminotherapy in Madagascar. Vitiligo is a refractory disease in which treatment modalities are not yet established. We aim to assess results obtained 10 years after the initiation of a therapeutic protocol which combines very potent topical corticosteroids (TCS), vitaminotherapy (B12 and C), and suppression of microtraumas in the management of nonsegmental vitiligo in Madagascar.It (...) was a prospective and descriptive study over a period of 6 years (2011-2016) in the Department of Dermatology, Joseph Raseta Befelatanana, Antananarivo, Madagascar. The diagnosis of vitiligo was based on clinical data. Patients who agreed to follow the treatment protocol, which combined very potent TCS (two applications/day for 10 days, and then one application/day for the following 10 days), oral vitamin C 500 mg/day for 20 days, and oral vitamin B12 100 mg/day for 20 days, were included in the study. Two

2019 International Journal of Dermatology

34. The incidence and survival of melanoma and nonmelanoma skin cancer in patients with vitiligo: a nationwide population-based matched cohort study in Korea. (Abstract)

The incidence and survival of melanoma and nonmelanoma skin cancer in patients with vitiligo: a nationwide population-based matched cohort study in Korea. While studies report a lower incidence of skin cancer in Caucasian vitiligo patients with controls, the skin cancer incidence in Asian vitiligo patients is unknown.We quantified the incidence of melanoma and nonmelanoma skin cancer (NMSC) in Korean vitiligo patients and compare it with their matched non-vitiligo controls.A retrospective (...) , matched cohort study was performed with 131,245 incident vitiligo cases and 2,624,900 age and sex-matched (1:20) controls at index date, who were selected between January 2005 and December 2017 from the Korean National Health Insurance database. Stratified Cox proportional hazards regression (stratified on gender, birth year, and index year) was used to calculate the hazard ratio (HR) of skin cancer in vitiligo patients.Vitiligo patients were followed up for a mean duration of 6·34 years compared

2019 British Journal of Dermatology

35. Comprehensive lipidomic, metabolomic and proteomic profiling reveals the role of immune system in vitiligo. (Abstract)

Comprehensive lipidomic, metabolomic and proteomic profiling reveals the role of immune system in vitiligo. Vitiligo is a common depigmentation disorder resulting from destruction of melanocytes, with both genetic and environmental influences. Although genomic analyses have been performed to investigate the pathogenesis of vitiligo, the lipidomics, metabolomics and proteomics of serum have not been reported and the role of small molecules and serum proteins in vitiligo remains unknown.To study (...) the metabolite and protein profiles in vitiligo and healthy controls, plasma samples from 60 participants (29 vitiligo and 31 healthy) were analyzed. Untargeted lipidomics, metabolomics and iTRAQ-based proteomics were performed using ultra-performance liquid chromatography-tandem mass spectrometry. In addition, to validate differentially expressed metabolites in vitiligo patients, plasma enzyme-linked immunosorbent assay was performed.We identified differential expression of several metabolites and proteins

2019 Clinical & Experimental Dermatology

36. Identification of CD49a+ CD8+ resident memory T cells in vitiligo-like lesions associated with nivolumab treatment for melanoma. (Abstract)

Identification of CD49a+ CD8+ resident memory T cells in vitiligo-like lesions associated with nivolumab treatment for melanoma. Immune checkpoint inhibitor (ICI) has brought major therapeutic advances in melanoma care, but ICI can cause unique side effects, often termed immune-related adverse events (irAEs), such as skin rash, vitiligo, colitis, and pneumonitis. Several recent studies revealed a correlation between occurrence of vitiligo-like lesions and clinical responses in advanced melanoma

2019 Journal of the European Academy of Dermatology and Venereology

37. Successful Treatment of Vitiligo Vietnamese Patients with Vitilinex® Herbal Bio-Actives in Combination with Phototherapy. Full Text available with Trip Pro

Successful Treatment of Vitiligo Vietnamese Patients with Vitilinex® Herbal Bio-Actives in Combination with Phototherapy. Vitiligo is an acquired pigmentary disease, that causes progressive loss of melanocytes, resulting in hypopigmented skin patches. Current treatments aim at stopping the disease progression and achieving repigmentation of the amelanotic areas. Corticosteroids, surgery, topical immunomodulators, total depigmentation of normal pigmented skin and phototherapy are current (...) treatment options for vitiligo although phototherapy remains the treatment of choice. There is no documented evidence that herbal bio-active products may also be effective treatment options for vitiligo.This study aimed to investigate the efficacy and safety of Vitilinex® (herbal bio- actives) alone and in combination with UVB narrowband (311 nm) phototherapy, in the treatment of localised stable or active forms of vitiligo.Sixty two subjects with mean age 34.5 years (range: 18-58 years) with mild

2019 Open access Macedonian journal of medical sciences Controlled trial quality: uncertain

38. Autologous noncultured melanocyte-keratinocyte transplantation in stable vitiligo: A randomized comparative study of recipient site preparation by two techniques. Full Text available with Trip Pro

Autologous noncultured melanocyte-keratinocyte transplantation in stable vitiligo: A randomized comparative study of recipient site preparation by two techniques. Accurate preparation of recipient area is a critical step in melanocyte-keratinocyte transplantation procedure for vitiligo. It is an important potential step for adaptation in the quest to achieve better results and ablative lasers potentially offer excellent precision over margin and depth control in achieving that.To compare (...) between the two techniques used for recipient site preparation: Er:YAG laser ablation and mechanical dermabrasion for melanocyte-keratinocyte transplantation procedure in terms of re-pigmentation achieved and adverse effects seen.A randomized comparative trial was performed among 32 patients of stable vitiligo undergoing melanocyte-keratinocyte transplantation procedure. In Group A (n = 15), recipient site preparation was done with Er:YAG laser, and in Group B (n = 17), it was done with a motorized

2019 Indian journal of dermatology, venereology and leprology Controlled trial quality: uncertain

39. The effectiveness of topical therapy combined with 308-nm excimer laser on vitiligo compared to excimer laser monotherapy in pediatric patients. Full Text available with Trip Pro

The effectiveness of topical therapy combined with 308-nm excimer laser on vitiligo compared to excimer laser monotherapy in pediatric patients. We evaluated the efficiency of using a 308-nm excimer laser with either tacrolimus, pimecrolimus, or halometasone for the treatment of childhood vitiligo. Patients who received combined treatments had significantly higher rates of repigmentation in comparison with individuals who underwent excimer laser alone therapy. Moreover, patients who received

2019 Pediatric dermatology Controlled trial quality: uncertain

40. A randomized comparative study of the effect of betamethasone oral mini-pulse therapy versus oral azathioprine in progressive non-segmental vitiligo. (Abstract)

A randomized comparative study of the effect of betamethasone oral mini-pulse therapy versus oral azathioprine in progressive non-segmental vitiligo. 30890339 2019 11 20 1097-6787 2019 Mar 16 Journal of the American Academy of Dermatology J. Am. Acad. Dermatol. A randomized comparative study of the effect of betamethasone oral mini-pulse therapy versus oral azathioprine in progressive non-segmental vitiligo. S0190-9622(19)30439-6 10.1016/j.jaad.2019.03.025 Patra Suman S Department (...) Am Acad Dermatol 7907132 0190-9622 Azathioprine Betamethasone Progressive vitiligo 2018 07 05 2019 02 19 2019 03 08 2019 3 21 6 0 2019 3 21 6 0 2019 3 21 6 0 aheadofprint 30890339 S0190-9622(19)30439-6 10.1016/j.jaad.2019.03.025

2019 Journal of the American Academy of Dermatology Controlled trial quality: uncertain

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>