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Vitiligo

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3481. Increase in total blood antioxidant status and selenium levels in black patients with active vitiligo. (PubMed)

Increase in total blood antioxidant status and selenium levels in black patients with active vitiligo. Oxidative stress could be an important phenomenon leading to melanocyte death in vitiligo. The accumulation of hydrogen peroxide (H2O2) and low catalase levels have recently been demonstrated in the epidermis of vitiligo patients. Few abnormalities of antioxidants have been found in the blood of patients with vitiligo, except for an elevation of selenium. No studies on oxidative stress have (...) been performed so far on patients with skin phototype VI (Fitzpatrick classification).To study the blood antioxidant status of black patients with active generalized vitiligo.Randox total antioxidant status, selenium, ferritin, transferrin, ceruloplasmin, tocopherol, and retinol levels were evaluated in blood samples obtained from 11 dark-skinned patients from the French West Indies (Isle of Martinique) with recent active lesions of vitiligo and from 11 age- and sex-matched healthy volunteers.Total

2002 International Journal of Dermatology

3482. Topical pseudocatalase mousse and narrowband UVB phototherapy is not effective for vitiligo: an open, single-centre study. (PubMed)

Topical pseudocatalase mousse and narrowband UVB phototherapy is not effective for vitiligo: an open, single-centre study. We report an open single-centre trial to assess the efficacy of topical pseudocatalase mousse applied twice daily to the hands and face of vitiligo patients, in combination with twice-weekly suberythemogenic narrowband UVB phototherapy. The regime was generally safe and well tolerated, although several patients experienced mild transient skin rashes in association (...) with application of the mousse and one patient suffered severe pruritus. The primary efficacy variable was the percentage change in area affected by vitiligo as assessed by digital interpretation of standardized photographs of the face and hands. There was no clear evidence of the efficacy of the regime and in fact a slight tendency overall to worsening of the patients' vitiligo.

2002 Clinical & Experimental Dermatology

3483. Topical prostaglandin analog (PGE2) in vitiligo--a preliminary study. (PubMed)

Topical prostaglandin analog (PGE2) in vitiligo--a preliminary study. Several therapeutic options are available for the treatment of vitiligo, but none is uniformly effective. Prostaglandin has been shown to play a role in melanocyte proliferation and melanogenesis. Topical application of prostaglandin E2 (PGE2) over mice skin has been shown to increase melanocyte density.To evaluate the role of topical PGE2 in the treatment of vitiligo.We enrolled 27 patients with limited vitiligo lesions

2002 International Journal of Dermatology

3484. Parametric modeling of narrowband UV-B phototherapy for vitiligo using a novel quantitative tool: the Vitiligo Area Scoring Index. (PubMed)

Parametric modeling of narrowband UV-B phototherapy for vitiligo using a novel quantitative tool: the Vitiligo Area Scoring Index. There is currently no quantitative tool for evaluating vitiligo treatment response using parametric methods.To develop and apply a simple clinical tool, the Vitiligo Area Scoring Index (VASI), to model the response of vitiligo to narrowband UV-B (NB-UV-B) phototherapy using parametric tests.Prospective, randomized, controlled, bilateral left-right comparison (...) trial.North American tertiary care, university-affiliated phototherapy center.Patients older than 18 years with stable vitiligo involving at least 5% of their total body surface in a symmetric distribution.Treatment with NB-UV-B was given 3 times a week to half of the body on all patients for either 60 treatments or 6 months. The contralateral side served as a no-treatment control.Repigmentation was assessed using the VASI, which was based on a composite estimate of the overall area of vitiligo patches

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2004 Archives of Dermatology

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