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Vitiligo

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3461. Epidermal grafting in vitiligo: influence of age, site of lesion, and type of disease on outcome. (Abstract)

Epidermal grafting in vitiligo: influence of age, site of lesion, and type of disease on outcome. The success of suction blister epidermal grafting may be influenced by various factors, all of which have not been studied to date.We sought to determine the influence of age of the patient, site of vitiligo patch, and type of disease on the outcome of the procedure in our patients and in the cumulative data derived from literature analysis.This was a retrospective, uncontrolled case series (...) and literature review of suction blister epidermal grafting in patients with stable and recalcitrant vitiligo. All published studies of suction blister epidermal grafting in vitiligo involving 10 or more patients were included in the literature analysis.The procedure was performed in 143 patients. However, sufficient length (6 postoperative months) of follow-up was available in only 117 patients, and only these patients were included for analysis. Only limited information was available about various factors

2003 Journal of American Academy of Dermatology

3462. Erbium:YAG laser and cultured epidermis in the surgical therapy of stable vitiligo. Full Text available with Trip Pro

Erbium:YAG laser and cultured epidermis in the surgical therapy of stable vitiligo. To induce complete and reproducible repigmentation of large "stable" vitiligo lesions by means of autologous cultured epidermal grafts using a rapid, simple, and minimally invasive surgical procedure.Achromic epidermis was removed by means of appropriately settled erbium:YAG laser, and autologous epidermal grafts were applied onto the recipient bed. Melanocyte content was evaluated by dopa reaction (...) . The percentage of repigmentation was calculated using a semiautomatic image analysis system.A biosafety level 3-type cell culture facility, a surgical ambulatory department, and a dermatological department in a hospital.Twenty-one patients with different types of vitiligo were admitted to the study and treated with autologous cultured epidermal grafts. Inclusion criteria were failure of at least 2 standard medical approaches; no therapy for at least 12 months; no progression of old lesions or appearance

2003 Archives of Dermatology

3463. Melanocyte detachment after skin friction in non lesional skin of patients with generalized vitiligo. (Abstract)

Melanocyte detachment after skin friction in non lesional skin of patients with generalized vitiligo. In vitiligo, melanocytes are gradually lost in depigmented macules of the skin. The disappearance of melanocytes has, however, not been clearly observed and consequently the aetiology of the disease (autoimmune, neural, cytotoxic) is still elusive. The starting point of vitiligo macules is frequently determined by local conditions such as wounds and excoriations, but may also follow minor (...) traumas such as pressure or repeated friction. This prominent feature is often neglected.To clarify the biological consequences of repeated friction on the attachment and survival of melanocytes in non lesional vitiligo skin.Light reproducible skin friction was performed for 4 min on the volar forearm of 18 patients with extensive vitiligo and five controls with normal healthy skin. Biopsies from the test area and control skin were taken at 1, 4, 24 and 48 h following friction. Serial sections were

2003 British Journal of Dermatology

3464. Parametric modeling of narrowband UV-B phototherapy for vitiligo using a novel quantitative tool: the Vitiligo Area Scoring Index. Full Text available with Trip Pro

Parametric modeling of narrowband UV-B phototherapy for vitiligo using a novel quantitative tool: the Vitiligo Area Scoring Index. There is currently no quantitative tool for evaluating vitiligo treatment response using parametric methods.To develop and apply a simple clinical tool, the Vitiligo Area Scoring Index (VASI), to model the response of vitiligo to narrowband UV-B (NB-UV-B) phototherapy using parametric tests.Prospective, randomized, controlled, bilateral left-right comparison (...) trial.North American tertiary care, university-affiliated phototherapy center.Patients older than 18 years with stable vitiligo involving at least 5% of their total body surface in a symmetric distribution.Treatment with NB-UV-B was given 3 times a week to half of the body on all patients for either 60 treatments or 6 months. The contralateral side served as a no-treatment control.Repigmentation was assessed using the VASI, which was based on a composite estimate of the overall area of vitiligo patches

2004 Archives of Dermatology Controlled trial quality: uncertain

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