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Vitiligo

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181. The effect of topical piperine combined with narrowband UVB on vitiligo treatment: A clinical trial study. (PubMed)

The effect of topical piperine combined with narrowband UVB on vitiligo treatment: A clinical trial study. Vitiligo is the most common acquired hypopigmentary disease in the community. Piperine as an herbal extract derived from black pepper has strong impact on the melanocyte proliferation and adverse side effects less than synthetic drugs such as corticosteroids. For the first time, this study was aimed to evaluate the effect of topical piperine combined with narrowband ultraviolet B (NB-UVB (...) ) on vitiligo treatment. In this double-blind clinical trial, 63 patients with facial vitiligo were randomly divided into 2 groups: treated with piperine (case) and placebo (control). Also, both groups received NB-UVB phototherapy every other day for 3 months. In the case group, 10 patients have burning sensation on their skin areas (p value = .002). Also, redness of the treated areas was observed in 6 patients (p value = .028). Both side effects were temporary. Regarding repigmentation at time intervals

2018 Phytotherapy research : PTR Controlled trial quality: uncertain

182. Potential emerging treatment in vitiligo using Er:YAG in combination with 5FU and clobetasol. (PubMed)

Potential emerging treatment in vitiligo using Er:YAG in combination with 5FU and clobetasol. Vitiligo is a pigmentary disorder of skin affecting at least 1% of the world population of all races in both sexes. Its importance is mainly due to subsequent social and psychological problems rather than clinical complications. Various treatment choices are available for vitiligo; however, laser-based courses have shown to give more acceptable results.The aim of this trial was to evaluate the efficacy (...) of Er:YAG laser as a supplementary medicine to topical 5FU and clobetasol in vitiligo patients.Two comparable vitiligo patches from 38 eligible patients were randomized to receive topical 5FU and clobetasol in control group and additional Er:YAG laser in intervention group. Major outcomes of interest were the size of patch and pigmentation score at randomization and 2 and 4 months after therapy.Final sample included 18 (47%) male patients and age of 35.66±8.04. The performance Er:YAG group was superior

2018 Journal of cosmetic dermatology Controlled trial quality: uncertain

183. Atorvastatin in Combination With Narrowband UV-B in Adult Patients With Active Vitiligo: A Randomized Clinical Trial. (PubMed)

Atorvastatin in Combination With Narrowband UV-B in Adult Patients With Active Vitiligo: A Randomized Clinical Trial. 29617528 2018 06 13 2168-6084 154 6 2018 Jun 01 JAMA dermatology JAMA Dermatol Atorvastatin in Combination With Narrowband UV-B in Adult Patients With Active Vitiligo: A Randomized Clinical Trial. 725-726 10.1001/jamadermatol.2017.6401 Nguyen Sophie S Department of Dermatology, Université Côte d'Azur, Centre Hospitalier Universitaire Nice, Nice, France. Chuah Sai Yee SY National

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2018 JAMA dermatology Controlled trial quality: uncertain

184. Preliminary study on the treatment of vitiligo with carbon dioxide fractional laser together with tacrolimus. (PubMed)

Preliminary study on the treatment of vitiligo with carbon dioxide fractional laser together with tacrolimus. Tacrolimus is a conventional medication for the treatment of vitiligo, but the effect of a single medication is limited.This paper aims at observing the effects, adverse responses, and repigmentation results of the joint treatment of vitiligo by Carbon dioxide (CO2 ) fractional laser together with tacrolimus.Forty-five patients with vitiligo were randomly divided into two groups (...) assessments. When the treatment time was increased, the efficacy was also improved, and the repigmentation in the T group occured in three ways: perifollicular repigmentation, marginal repigmentation and diffuse repigmentation. There were three cases of isomorphic responses (2 cases in the rapid progression stage, one case in the progression stage), and 1 case formed scarring on the neck in the T group.The treatment of vitiligo by CO2 fractional laser together with tacrolimus is significantly effective

2018 Lasers in surgery and medicine Controlled trial quality: uncertain

185. Efficacy of oral cholecalciferol on rhododendrol-induced vitiligo: A blinded randomized clinical trial. (PubMed)

Efficacy of oral cholecalciferol on rhododendrol-induced vitiligo: A blinded randomized clinical trial. Rhododendrol (RD), 4-(4-hydroxyphenyl)-2-butanol, inhibits melanin synthesis and has been used for skin-whitening cosmetic products. RD has been very effective in lightening skin pigmentation, but some persons have developed so-called RD vitiligo, in which vitiligo starts on the face, neck and hands where topical RD has been applied and even extended over skin areas where RD has not been (...) applied. RD vitiligo lesions in some patients have lasted for years and have been resistant to conventional vitiligo treatments. We examined the effects of cholecalciferol on RD vitiligo in a blinded randomized clinical trial. Forty-eight female RD vitiligo patients were recruited for the trial and were randomized into two groups: the vitamin D (VD)-intervention group that received daily 5000 IU cholecalciferol for 5 months and the control group. Three blinded investigators scored vitiligo improvement

2018 The Journal of dermatology Controlled trial quality: uncertain

186. Improvement in moderate to severe vitiligo using a novel combination of 308 nm excimer laser and a surgical needling technique. (PubMed)

Improvement in moderate to severe vitiligo using a novel combination of 308 nm excimer laser and a surgical needling technique. 28300320 2018 08 20 2018 08 20 1365-2230 42 3 2017 Apr Clinical and experimental dermatology Clin. Exp. Dermatol. Improvement in moderate to severe vitiligo using a novel combination of 308 nm excimer laser and a surgical needling technique. 363-366 10.1111/ced.13056 BinSheikhan S S Department of Dermatology, Zayed Military Hospital, Abu Dhabi, United Arab Emirates (...) . Al Abadie M M http://orcid.org/0000-0002-0727-4632 Department of Dermatology, Royal Wolverhampton NHS Trust, Wolverhampton, and Medical School, Birmingham, West Midlands, UK. eng Journal Article Randomized Controlled Trial England Clin Exp Dermatol 7606847 0307-6938 IM Adolescent Adult Aged Combined Modality Therapy Female Humans Lasers, Excimer therapeutic use Low-Level Light Therapy adverse effects instrumentation Male Middle Aged Needles Vitiligo radiotherapy surgery Young Adult 2016 04 06

2018 Clinical and experimental dermatology Controlled trial quality: uncertain

187. Evaluation of Using Fractional CO<sub>2</sub> Laser plus NB-UVB versus NB-UVB Alone in Inducing Marginal Repigmentation of Vitiligo Lesions. (PubMed)

Evaluation of Using Fractional CO2 Laser plus NB-UVB versus NB-UVB Alone in Inducing Marginal Repigmentation of Vitiligo Lesions. Vitiligo is a common depigmenting skin disorder, characterized by patchy loss of skin color and finding effective treatment has remained a challenging issue.A paired (half-body) randomized clinical trial study was done to compare the efficacy and the safety of narrowband ultraviolet B (NB-UVB) plus fractional CO2 versus NB-UVB alone in stimulation (...) of marginal repigmentation of vitiliginous patches. One side of the body was randomly treated with a fractional CO2 laser and NB-UVB twice weekly, while the other side was exposed only to NB-UVB with the same manner.Thirty patients with the non-segmental stable vitiligo and mean age of 43 ± 15 years completed a 16-week treatment period with NB-UVB on one side of the body and fractional CO2 laser therapy with NB-UBV on the other side. In addition to the higher rate of response in the combination side

2018 Journal of Dermatological Treatment Controlled trial quality: uncertain

188. Use of platelet-rich plasma to suspend noncultured epidermal cell suspension improves repigmentation after autologous transplantation in stable vitiligo: a double-blind randomized controlled trial. (PubMed)

Use of platelet-rich plasma to suspend noncultured epidermal cell suspension improves repigmentation after autologous transplantation in stable vitiligo: a double-blind randomized controlled trial. Noncultured epidermal cell suspension (NCES) is an effective surgical modality for stable vitiligo which involves transplantation of the basal layer of epidermal cells onto the dermabraded vitiliginous patch. Platelet-rich plasma (PRP) has growth factors which may stimulate melanocyte migration (...) and proliferation of keratinocytes and fibroblasts. The objective of this study was to compare the extent of repigmentation achieved by transplantation of NCES suspended in PRP with that of NCES suspended in phosphate buffered saline (PBS).Twenty-one patients of stable vitiligo with at least two lesions of comparable size were included. The two vitiligo patches were randomized to receive NCES suspended in PRP or PBS. Postoperatively after 1 week, patients were given heliotherapy for 15 minutes daily.At 6 months

2018 International Journal of Dermatology Controlled trial quality: uncertain

189. Ablative fractional Co<sub>2</sub> laser aided delivery of long-acting glucocorticoid in the treatment of acral vitiligo: A multicenter, prospective, self- bilateral controlled study. (PubMed)

Ablative fractional Co2 laser aided delivery of long-acting glucocorticoid in the treatment of acral vitiligo: A multicenter, prospective, self- bilateral controlled study. Acral vitiligo often responses poorly to treatments.To observe whether pretreatment with ablative fractional CO2 laser aiding penetration of compound betamethasone solution plus NB-UVB could improve the response of refractory acral vitiligo.Subjects with symmetrical and stable acral vitiligo were enrolled (...) eighty-nine subjects entered the clinical trial and 126 subjects completed the study. The experiment side showed better improvement in repigmentation. Overall response rate (repigmentation percentage ≥10%) of experiment sides was 51.6%, in contrast, that of control side was 35.8%. There were no severe adverse events in all subjects during the trial.A triple method of ablative fractional CO2 laser, topical compound betamethasone solution plus NB-UVB provided an alternative choice for acral vitiligo

2018 Journal of Dermatological Treatment Controlled trial quality: uncertain

190. Four compartment method as an efficacious and simplified technique for autologous non-cultured epidermal cell suspension preparation in vitiligo surgery: A randomized, active-controlled study. (PubMed)

Four compartment method as an efficacious and simplified technique for autologous non-cultured epidermal cell suspension preparation in vitiligo surgery: A randomized, active-controlled study. Autologous non-cultured epidermal cell suspension (NCES) is a successful surgical method for repigmentation of stable, refractory vitiligo. The need for laboratory equipment and expertise restricts its use to only a few research centres; hence, there is a requisite to simplify the technique of NCES (...) preparation.To evaluate the efficacy of NCES prepared by four compartment (4C) method compared to the laboratory-based method (lab-NCES).Anatomically based matched lesions (41 pairs) in 30 stable vitiligo patients were randomized to receive NCES prepared by 4C method or lab-NCES. Each patient was evaluated at 4, 8, 16 weeks after surgery by a blinded observer with regard to extent of repigmentation, colour match, patient global assessment (PGA) and pattern of repigmentation.Repigmentation outcome in 4C

2018 Journal of the European Academy of Dermatology and Venereology Controlled trial quality: uncertain

191. Combination of Follicular and Epidermal Cell Suspension as a Novel Surgical Approach in Difficult-to-Treat Vitiligo: A Randomized Clinical Trial. (PubMed)

Combination of Follicular and Epidermal Cell Suspension as a Novel Surgical Approach in Difficult-to-Treat Vitiligo: A Randomized Clinical Trial. Epidermal cell suspension (ECS) and follicular cell suspension (FCS) are successful surgical modalities for the treatment of stable vitiligo. However, repigmentation in generalized and acrofacial vitiligo and over acral or bony sites (eg, elbows, knees, iliac crests, and malleoli), which are difficult to treat, is challenging.To study the efficacy (...) of transplanting a combination of autologous, noncultured ECS and FCS (ECS + FCS) compared with ECS alone in stable vitiligo.A prospective, observer-blinded, active-controlled, randomized clinical trial was conducted at a tertiary care hospital, with treatment administered as an outpatient procedure. Thirty participants who had stable vitiligo with symmetrical lesions were recruited between October 18, 2013, and October 28, 2016. All of the lesions were resistant to medical modalities with minimum lesional

2018 JAMA dermatology (Chicago, Ill.) Controlled trial quality: uncertain

192. Comparison of microneedling and full surface erbium laser dermabrasion for autologous cell suspension grafting in non-segmental vitiligo: a randomized controlled trial. (PubMed)

Comparison of microneedling and full surface erbium laser dermabrasion for autologous cell suspension grafting in non-segmental vitiligo: a randomized controlled trial. 30488531 2019 02 14 1365-2133 2018 Nov 29 The British journal of dermatology Br. J. Dermatol. Comparison of microneedling and full surface erbium laser dermabrasion for autologous cell suspension grafting in nonsegmental vitiligo: a randomized controlled trial. 10.1111/bjd.17464 Lagrange S S Department of Dermatology, Centre

2018 British Journal of Dermatology Controlled trial quality: uncertain

193. Vitiligo in Children: A Better Understanding of the Disease (PubMed)

Vitiligo in Children: A Better Understanding of the Disease Vitiligo is an important skin disease of childhood. The authors briefly discuss the etiopathobiology, clinics and comorbidities of the disease.

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2018 Open access Macedonian journal of medical sciences

194. Unconventional Treatments for Vitiligo: Are They (Un) Satisfactory? (PubMed)

Unconventional Treatments for Vitiligo: Are They (Un) Satisfactory? The authors show a brief overview of the vitiligo's unconventional therapies. A part for well-documented effectiveness of L-phenylalanine, PGE2 and antioxidant agents in the treatment of vitiligo, for the other therapeutical approaches more investigations are needed.

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2018 Open access Macedonian journal of medical sciences

195. Herbal Compounds for the Treatment of Vitiligo: A Review (PubMed)

Herbal Compounds for the Treatment of Vitiligo: A Review An overview of unconventional therapies for vitiligo is presented. Some herbal compounds may be considered as valid therapeutic tools for the treatment of vitiligo.

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2018 Open access Macedonian journal of medical sciences

196. Vitiligo in Children: A Review of Conventional Treatments (PubMed)

Vitiligo in Children: A Review of Conventional Treatments Vitiligo is an important skin disease of childhood, which may lead to deep psychological trauma, resulting in a poor quality of life and low self-esteem. The Authors discuss a short review of the more conventional therapies available for the treatment of vitiligo in children.

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2018 Open access Macedonian journal of medical sciences

197. Vitiligo in Children: What’s New in Treatment? (PubMed)

Vitiligo in Children: What’s New in Treatment? Vitiligo is an acquired chronic hypopigmentary disorder, which usually stars in childhood. The Authors discuss a short review of the more innovative therapies for childhood vitiligo.

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2018 Open access Macedonian journal of medical sciences

198. Successful Treatment with UVA 1 Laser of Non - Responder Vitiligo Patients (PubMed)

Successful Treatment with UVA 1 Laser of Non - Responder Vitiligo Patients The Authors discuss their experience in treating non-responder vitiligo patients with a UVA-1 laser. Laser Alba 355® is an innovative device of target UVA - 1 phototherapy. The present report suggests that UVA1 laser could be an applicable therapeutic option in patients with vitiligo, also for the ones who did not respond to the more conventional phototherapies.

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2018 Open access Macedonian journal of medical sciences

199. Micro - Focused Phototherapy Associated To Janus Kinase Inhibitor: A Promising Valid Therapeutic Option for Patients with Localized Vitiligo (PubMed)

Micro - Focused Phototherapy Associated To Janus Kinase Inhibitor: A Promising Valid Therapeutic Option for Patients with Localized Vitiligo Vitiligo is an acquired pigmentary cutaneous disease, characterised by the progressive loss of melanocytes, resulting in hypopigmented skin areas which progressively become amelanotic. Classically, vitiligo treatments are unsatisfactory and challenging. Despite the continuous introduction of new therapies, phototherapy is still the mainstay for vitiligo (...) (72%) obtained a re-pigmentation rate higher than 75%, with a medium value of 77%. 11 patients (19%) achieved a marked improvement of the clinical findings with a repigmentation rate between 50-75%; 4 patients (8%) showed a moderate response with a lesional repigmentation of 25-50%. Only one patient (1%) had a poor response to the phototherapeutic treatment.Nb - UVB micro-focused phototherapy is one of the most effective therapeutic options for vitiligo treatment. The association of micro-focused

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2018 Open access Macedonian journal of medical sciences

200. An Innovative Therapeutic Protocol for Vitiligo: Experience with the Use of Fraxel Herbium Laser, Topical Latanoprost and Successive Irradiation with UVA - 1 Laser (PubMed)

An Innovative Therapeutic Protocol for Vitiligo: Experience with the Use of Fraxel Herbium Laser, Topical Latanoprost and Successive Irradiation with UVA - 1 Laser Despite the continuous introduction of innovative therapies for vitiligo, today none of them provide constant and excellent results in term of repigmentation. The authors report their experience in treating a localised form of vitiligo with a new protocol consisting in the use of a Fraxel Herbium laser, and in the following

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2018 Open access Macedonian journal of medical sciences

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