How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

3,484 results for

Vitiligo

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

181. Vitiligo Skin: Exploring the Dermal Compartment. (PubMed)

Vitiligo Skin: Exploring the Dermal Compartment. There is an increasing interest in the apparently normal skin in vitiligo. Altered expression of the adhesion molecule E-cadherin and persistent deregulated intracellular redox status that promotes the acquisition of a stress-induced senescent phenotype in melanocytes of normally pigmented skin from patients with vitiligo have been described. Growing evidence has shown that such cellular and functional alterations are not necessarily restricted (...) to melanocytes but may be extended to other cutaneous cell populations in both lesional and nonlesional areas. However, whether dermal fibroblasts exhibit related alterations that may contribute to the defects associated with melanocytes in vitiligo is not known. Here we reveal within the dermal compartment cells a myofibroblast phenotype and a predisposition to premature senescence, indicating the existence of altered cross-talk between dermal and epidermal components that may affect melanocyte

2017 Journal of Investigative Dermatology

182. The prevalence of psychological co-morbidity in people with vitiligo: a systematic review and meta-analysis. (PubMed)

The prevalence of psychological co-morbidity in people with vitiligo: a systematic review and meta-analysis. Vitiligo is a chronic disorder causing skin depigmentation with global prevalence varying from 0·2% to 1·8%. U.K. guidelines recommend assessment of psychological state during clinical evaluation of vitiligo. However, the prevalence of psychological comorbidity in people with vitiligo has not been described.To establish the prevalence of psychological symptoms or disorders in people (...) with vitiligo and describe the outcome measures used.We performed a comprehensive search of MEDLINE, Embase, CINAHL and PsycINFO to identify observational studies assessing the prevalence of psychological symptoms or disorders (December 2016). DerSimonian and Lard random-effects models were used to estimate the overall pooled prevalence.We identified 29 studies with 2530 people with vitiligo. Most studies included a measure of either depression (n = 25) or anxiety (n = 13). The commonest tools were

Full Text available with Trip Pro

2017 The British journal of dermatology

183. Meta-analysis of the association between NLRP1 polymorphisms and the susceptibility to vitiligo and associated autoimmune diseases. (PubMed)

Meta-analysis of the association between NLRP1 polymorphisms and the susceptibility to vitiligo and associated autoimmune diseases. Genetic variants are linked to vitiligo and associated autoimmune diseases. We performed a meta-analysis to evaluate the effects of the rs12150220, rs2670660, and rs6502867 polymorphisms within the human NLR Family Pyrin Domain Containing 1 (NLRP1) gene. We initially identified 1,306 candidate articles through literature searches of Pubmed, WOS, Embase, CNKI (...) , WANFANGI, Ovid, Scopus, and Cochrane in July 2017. After strict screening, we included 19 eligible case-control studies, and analyzed the data using Stata/SE 12.0 software. No difference between vitiligo cases and controls was detected for NLRP1 rs12150220, rs2670660, or rs6502867 under most genetic models [Passociation (P value of association test) > 0.05). With regard to vitiligo-associated autoimmune diseases, like Addison's disease, type 1 diabetes, or systemic lupus erythematosus, a decreased risk

Full Text available with Trip Pro

2017 Oncotarget

184. Vitiligo skin is imprinted with resident memory CD8 T cells expressing CXCR3. (PubMed)

Vitiligo skin is imprinted with resident memory CD8 T cells expressing CXCR3. Vitiligo is a chronic autoimmune depigmenting skin disorder that results from a loss of melanocytes. Multiple combinatorial factors have been involved in disease development, with a prominent role of the immune system, in particular T cells. After repigmentation, vitiligo frequently recurs in the same area, suggesting that vitiligo could involve the presence of resident memory T cells (TRM). We sought to perform (...) a thorough characterization of the phenotype and function of skin memory T cells in vitiligo. We show that stable and active vitiligo perilesional skin is enriched with a population of CD8 TRM expressing both CD69 and CD103 compared with psoriasis and control unaffected skin. CD8 TRM expressing CD103 are mainly localized in the epidermis. Expression of CXCR3 is observed on most CD8 TRM in vitiligo, including the population of melanocyte-specific CD8 T cells. CD8 TRM displayed increased production of IFN

2017 Journal of Investigative Dermatology

185. Increased risk of vitiligo following anti-TNF therapy: A 10-year population-based cohort study. (PubMed)

Increased risk of vitiligo following anti-TNF therapy: A 10-year population-based cohort study. Anti-tumor necrosis factor-α (anti-TNF) therapy is used to treat a wide range of chronic inflammatory conditions. However, there has been an increasing number of reports of development of vitiligo and alopecia areata secondary to anti-TNF therapy. In this study, we investigated the risks of vitiligo and alopecia areata in patients with ankylosing spondylitis, Crohn's disease, or ulcerative colitis (...) , who were treated with or without anti-TNF therapy using data from the Korean National Health Insurance Claims database from 2007 to 2016. The study comprised 11,442 patients treated with anti-TNF agents (anti-TNF group), and an equal number of age-, sex-, and disease- matched patients treated without anti-TNF agents (unexposed group). Multivariable Cox proportional hazards models were used to compare the risks of vitiligo and alopecia areata between the two groups. A significantly increased risk

2017 Journal of Investigative Dermatology

186. The Prevalence and Odds of Depression in Patients with Vitiligo: a Meta-Analysis. (PubMed)

The Prevalence and Odds of Depression in Patients with Vitiligo: a Meta-Analysis. The objective of this study was to provide a pooled estimate of the prevalence and odds of depression in patients with vitiligo.A systematic literature search of Medline, Embase and Cochrane library databases was conducted. The proportions and mean questionnaire values for depression were pooled according to different evaluation methods. In controlled studies, odds ratio and standardized mean differences compared (...) depression in vitiligo patients with healthy controls.One thousand nine hundred and sixty-five patients were identified from 20 eligible cohorts to be included in the present meta-analysis review. Sample sizes ranged from 30 to 308 for each analysis. The pooled prevalence of depression across 17 unique populations (n = 1711) was 29% (95% CI 20-39). The prevalence of clinical depression was 8% (95% CI 2%-14%) using Diagnostic and Statistical Manual of Mental Disorders IV or International Classification

2017 Journal of the European Academy of Dermatology and Venereology

187. A single-arm open-label clinical trial of autologous epidermal cell transplantation for stable vitiligo: A 30-month follow-up. (PubMed)

A single-arm open-label clinical trial of autologous epidermal cell transplantation for stable vitiligo: A 30-month follow-up. Recently, we introduced intralesional injection of autologous epidermal cells as a safe and feasible approach for transplantation in patients with stable vitiligo. This approach resulted in less pain during and after the procedure, no scarring or cobblestone formation at the recipient site, and was more feasible to perform on curved surfaces such as joints, lips (...) , eyelids, ears, and face.In this study, we aimed to investigate the long-term efficacy and safety of this transplantation technique.In this open-label and single-arm clinical trial, we enrolled 300 patients with stable vitiligo. We obtained a partial thickness normo-pigmented skin specimen from the patients' thigh-buttock junction with an area of one tenth to one third of the recipient site area. The epidermal cell suspension was prepared by processing the autologous skin specimen. We injected the cell

2017 Journal of dermatological science

188. Fractional Carbon Dioxide Laser as an "Add-on" Treatment for Vitiligo: A Meta-analysis with Systematic Review. (PubMed)

Fractional Carbon Dioxide Laser as an "Add-on" Treatment for Vitiligo: A Meta-analysis with Systematic Review. Treatment of vitiligo is challenging and requires a multidisciplinary approach. Fractional carbon dioxide (CO2) laser as an add-on to conventional treatment has been reported to be effective, but there is no consensus on its use. A systematic review was performed by searching major databases for relevant publications to February 2017. Six studies with 85 participants were included (...) . For those with refractory vitiligo, the addition of fractional CO2 laser to routine treatment modalities was superior to conventional treatment alone in terms of > 50% re-pigmentation (risk ratio (RR) 4.90, 95% confidence interval (95% CI), 1.15-20.93; p = 0.03), physician improvement score (mean difference (MD) 0.81, 95% CI 0.33-1.29; p < 0.001), < 25% re-pigmentation (RR 0.64, 95% CI, 0.49-0.85; p=0.002) and patient satisfaction (MD 1.61, 95% CI 0.73-2.49; p< 0.001). Side-effects were minor

Full Text available with Trip Pro

2017 Acta Dermato-Venereologica

189. Dermoscopy in vitiligo: diagnosis and beyond. (PubMed)

Dermoscopy in vitiligo: diagnosis and beyond. Vitiligo is essentially a clinical diagnosis, and dermoscopy may aid in noninvasive confirmation of diagnosis by excluding other clinically simulating hypopigmentary conditions. More importantly, dermoscopy is rapidly gaining ground as an important adjunct tool to evaluate disease activity.To study the dermoscopic features of vitiligo and ascertain their correlation with disease activity.Retrospective analysis of dermoscopy of 60 cases suffering (...) from vitiligo was undertaken. Dermoscopy was performed using Dermlite II hybrid m dermatoscope at 10× magnification in polarized mode, and photographs were captured by Apple iphone 6. Variables assessed in the dermoscopic evaluation included perifollicular changes, perilesional changes, altered pigmentary network, and presence of specific features such as the starburst appearance, comet tail appearance, leukotrichia, telangiectasia, and any new findings.Sixty patients with stable, progressive

Full Text available with Trip Pro

2017 International Journal of Dermatology

190. Quality of life in people with vitiligo: a systematic review and meta-analysis. (PubMed)

Quality of life in people with vitiligo: a systematic review and meta-analysis. 28869779 2019 03 19 2019 03 19 1365-2133 177 6 2017 12 The British journal of dermatology Br. J. Dermatol. Quality of life in people with vitiligo: a systematic review and meta-analysis. e338-e339 10.1111/bjd.15933 Morrison B B Medical School, University of Nottingham, Nottingham, U.K. Burden-Teh E E 0000-0002-0033-2836 Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, U.K. Batchelor J M JM (...) of Life psychology Sex Factors Vitiligo psychology 2017 9 5 6 0 2019 3 20 6 0 2017 9 5 6 0 ppublish 28869779 10.1111/bjd.15933

Full Text available with Trip Pro

2017 The British journal of dermatology

191. Increased levels of mitochondrial DNA copy number in patients with vitiligo. (PubMed)

Increased levels of mitochondrial DNA copy number in patients with vitiligo. Oxidative stress is known to be involved in the pathogenesis of autoimmune diseases such as vitiligo. Evidence suggests that the human mitochondrial DNA copy number (mtDNAcn) is vulnerable to damage mediated by oxidative stress. The purpose of this study was to examine and compare peripheral blood mtDNAcn and oxidative DNA damage byproducts (8-hydroxy-2-deoxyguanosine; 8-OHdG) in patients with vitiligo and healthy (...) controls (HCs).The relative mtDNAcn and the oxidative damage (formation of 8-OHdG in mtDNA) of each sample were determined by real-time quantitative PCR. Blood samples were obtained from 56 patients with vitiligo and 46 HCs.The mean mtDNAcn and the degree of mtDNA damage were higher in patients with vitiligo than in HCs.These data suggest that increase in mtDNAcn and oxidative DNA damage may be involved in the pathogenesis of vitiligo.© 2017 British Association of Dermatologists.

2017 Clinical & Experimental Dermatology

192. Metabo-miR: miR-211 Regulates Mitochondrial Energy Metabolism in Vitiligo. (PubMed)

Metabo-miR: miR-211 Regulates Mitochondrial Energy Metabolism in Vitiligo. The study by Sahoo et al. established miR-211 as a critical regulator of cellular metabolism in vitiligo cells. miR-211, which is expressed from the transient receptor potential melastatin 1 intronic region, regulates oxidative phosphorylation and mitochondrial energy metabolism in vitiligo. Loss of miR-211 in melanocytes was shown to alter expression patterns of newly identified target genes, and those that regulate

2017 Journal of Investigative Dermatology

193. Quality of life in patients with vitiligo using the short form 36. (PubMed)

Quality of life in patients with vitiligo using the short form 36. 28872663 2019 03 25 2019 03 25 1365-2133 177 6 2017 12 The British journal of dermatology Br. J. Dermatol. Quality of life in patients with vitiligo using the Short Form-36. 1764-1766 10.1111/bjd.15936 Yang Y Y Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, U.S.A. Zapata L L Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, U.S.A. Rodgers C C (...) L S LS Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, U.S.A. Pandya A G AG 0000-0002-3916-2651 Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, U.S.A. eng Letter 2017 11 15 England Br J Dermatol 0004041 0007-0963 IM Adult Case-Control Studies Female Health Status Humans Male Mental Health Middle Aged Quality of Life psychology Surveys and Questionnaires Vitiligo psychology 2017 9 6 6 0 2019 3 26 6 0 2017 9 6 6

2017 British Journal of Dermatology

194. Circulating CXCL10 is increased in non-segmental vitiligo, in presence or absence of autoimmune thyroiditis. (PubMed)

Circulating CXCL10 is increased in non-segmental vitiligo, in presence or absence of autoimmune thyroiditis. Recently the importance of CXCL10 in the pathogenesis of non-segmental vitiligo (NSV) and autoimmune thyroid disorders (AITD) has been shown. No data are present about chemokines CXCL10 (Th1 prototype) and CCL2 (Th2 prototype) circulating levels in NSV patients with/without thyroiditis (AT). Serum CXCL10 and CCL2 have been measured in 50 consecutive NSV patients, in 40 consecutive

2017 Autoimmunity reviews

195. Vitiligo: Focus on Clinical Aspects, Immunopathogenesis, and Therapy. (PubMed)

Vitiligo: Focus on Clinical Aspects, Immunopathogenesis, and Therapy. Vitiligo is an acquired chronic depigmenting disorder of the skin, with an estimated prevalence of 0.5% of the general population, characterized by the development of white macules resulting from a loss of epidermal melanocytes. The nomenclature has been revised after an extensive international work within the vitiligo global issues consensus conference, and vitiligo (formerly non-segmental vitiligo) is now a consensus (...) umbrella term for all forms of generalized vitiligo. Two other subsets of vitiligo are segmental vitiligo and unclassified/undetermined vitiligo, which corresponds to focal disease and rare variants. A series of hypopigmented disorders may masquerade as vitiligo, and some of them need to be ruled out by specific procedures including a skin biopsy. Multiple mechanisms are involved in melanocyte disappearance, namely genetic predisposition, environmental triggers, metabolic abnormalities, impaired

2017 Clinical Reviews in Allergy & Immunology

196. New discoveries in the pathogenesis and classification of vitiligo. (PubMed)

New discoveries in the pathogenesis and classification of vitiligo. Vitiligo is a common autoimmune disease that progressively destroys melanocytes in the skin, resulting in the appearance of patchy depigmentation. This disfiguring condition frequently affects the face and other visible areas of the body, which can be psychologically devastating. The onset of vitiligo often occurs in younger individuals and progresses for life, resulting in a heavy burden of disease and decreased quality (...) of life. Presentation patterns of vitiligo vary, and recognition of these patterns provides both diagnostic and prognostic clues. Recent insights into disease pathogenesis offer a better understanding of the natural history of the disease, its associations, and potential for future treatments. The first article in this continuing medical education series outlines typical and atypical presentations of vitiligo, how they reflect disease activity, prognosis, and response to treatment. Finally, we discuss

2017 Journal of American Academy of Dermatology

197. Current and emerging treatments for vitiligo. (PubMed)

Current and emerging treatments for vitiligo. Clinicians should be aware that vitiligo is not merely a cosmetic disease and that there are safe and effective treatments available for vitiligo. It is important to recognize common and uncommon presentations and those with active disease, as well as their implications for clinical management; these were discussed in the first article in this continuing medical education series. Existing treatments include topical and systemic immunosuppressants

2017 Journal of American Academy of Dermatology

198. Biomarkers of disease activity in vitiligo: A systematic review. (PubMed)

Biomarkers of disease activity in vitiligo: A systematic review. The pathophysiology of vitiligo is complex although recent research has discovered several markers which are linked to vitiligo and associated with disease activity. Besides providing insights into the driving mechanisms of vitiligo, these findings could reveal potential biomarkers. Activity markers can be used to monitor disease activity in clinical trials and may also be useful in daily practice. The aim of this systematic (...) review was to document which factors have been associated with vitiligo activity in skin and blood. A second goal was to determine how well these factors are validated in terms of sensitivity and specificity as biomarkers to determine vitiligo activity. Both in skin (n=43) as in blood (n=66) an adequate number of studies fulfilled the predefined inclusion criteria. These studies used diverse methods and investigated a broad range of plausible biomarkers. Unfortunately, sensitivity and specificity

Full Text available with Trip Pro

2017 Autoimmunity reviews

199. S100B: Correlation with Active Vitiligo Depigmentation. (PubMed)

S100B: Correlation with Active Vitiligo Depigmentation. Vitiligo, the most common depigmenting disorder, is caused by immune destruction of melanocytes by cytotoxic CD8+ T cells. One weakness in vitiligo management is the lack of an assessment method for active depigmentation. Beginning with reports about increased S100B levels in different inflammatory and tissue damage processes, Speeckaert et al. explored correlations between the S100B dynamics and vitiligo activity, identifying high

2017 Journal of Investigative Dermatology

200. Corrigendum to "Glutathione Peroxidase Level in Patients with Vitiligo: A Meta-Analysis". (PubMed)

Corrigendum to "Glutathione Peroxidase Level in Patients with Vitiligo: A Meta-Analysis". [This corrects the article DOI: 10.1155/2016/3029810.].

Full Text available with Trip Pro

2017 BioMed research international

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>