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Vitiligo

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1. Quality of life of adult vitiligo patients using camouflage: A survey in a Chinese vitiligo community. (PubMed)

Quality of life of adult vitiligo patients using camouflage: A survey in a Chinese vitiligo community. Vitiligo is an acquired depigmented skin disease resulting in white macules, which may significantly impair the quality of life (QoL) of the patients.To estimate the QoL in Chinese vitiligo patients using camouflage with a more detailed description, and to identify the possible risk factors related to poor QoL.An online survey was conducted in vitiligo patients using camouflage from a vitiligo (...) community. Survey questions included demographic, clinical information, dermatology- and vitiligo-specific QoL questionnaires. Multivariate logistic analysis was performed to identify risk factors that related to poor QoL.In total, 884 respondents were included in the analyses, of which 413 (46.7%) were male. The score of DLQI was 5.83±5.75 (mean± SD). Age, gender, marriage status, occupational status, anogenital involvement, patient-perceived severity (presented by VAS score), symptoms as itching, pain

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2019 PLoS ONE

3. Vitiligo

Vitiligo Vitiligo - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Vitiligo Last reviewed: February 2019 Last updated: July 2018 Summary Common acquired multi-factorial skin disease exhibiting progressive depigmentation of the epidermis in circumscribed areas, typically without erythema or scaling. Multiple auto-immune disorders may be associated with vitiligo, most commonly auto-immune thyroiditis. In light-skinned (...) to induce repigmentation, treatments such as UV-B light, topical immunosuppressants, and combination approaches using phototherapy can provide significant improvement in most cases. Definition Vitiligo is an acquired loss of melanocytes in circumscribed areas of the epidermis, resulting in complete depigmentation of affected skin. The extent of the disease ranges from limited, focal disease to almost complete (universal) pigment loss. History and exam presence of risk factors acral and periorificial

2018 BMJ Best Practice

4. A multi-center, randomized, split face and/or neckcomparisonof 308-nm excimer laser and0·1%tacrolimus ointmentfor stable vitiligo, plus intramuscular slow releasing betamethasone for active vitiligo. (PubMed)

A multi-center, randomized, split face and/or neckcomparisonof 308-nm excimer laser and0·1%tacrolimus ointmentfor stable vitiligo, plus intramuscular slow releasing betamethasone for active vitiligo. Managing patients with vitiligo is no longer whether to treat or not to treat, but to decide what modalities are more appropriate. Both topical calcineurin inhibitors and 308-nm excimer laser (EL) were generally accepted to treat vitiligo, and the combination of the two achieved better (...) efficacy.However, there has been no strict comparison of the two methods in treating facial/neck vitiligo. Here we conducted a multi-center,randomized, left-right comparative trial in face and/or neck vitiligo,between 2012 and 2014.It was approved by medical ethics committees and official registered (ChiCTR-TRC-12002593). Informed consents were signed. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.

2019 British Journal of Dermatology

5. Tacrolimus for the Treatment of Adults with Psoriasis or Vitiligo: A Review of the Clinical and Cost-Effectiveness

Tacrolimus for the Treatment of Adults with Psoriasis or Vitiligo: A Review of the Clinical and Cost-Effectiveness Tacrolimus for the Treatment of Adults with Psoriasis or Vitiligo: A Review of the Clinical and Cost-Effectiveness | CADTH.ca Find the information you need Tacrolimus for the Treatment of Adults with Psoriasis or Vitiligo: A Review of the Clinical and Cost-Effectiveness Tacrolimus for the Treatment of Adults with Psoriasis or Vitiligo: A Review of the Clinical and Cost (...) -Effectiveness Published on: October 11, 2017 Project Number: RC0920-000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of tacrolimus for the treatment of adults with psoriasis? What is the clinical effectiveness of tacrolimus for the treatment of adults with vitiligo? What is the cost-effectiveness of tacrolimus for the treatment of adults with psoriasis? What is the cost-effectiveness of tacrolimus

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

6. Identifying key components for a psychological intervention for people with vitiligo - a quantitative and qualitative study in the United Kingdom using web-based questionnaires of people with vitiligo and healthcare professionals. (PubMed)

Identifying key components for a psychological intervention for people with vitiligo - a quantitative and qualitative study in the United Kingdom using web-based questionnaires of people with vitiligo and healthcare professionals. Psychological interventions are recommended as part of routine management of vitiligo. However, the development and effectiveness of such interventions have been rarely addressed. This study aimed to identify key components for a psychological intervention for people (...) with vitiligo. This is the first time perspectives of people with vitiligo, and healthcare professionals (HCPs) have been directly explored to inform intervention content and delivery.To identify 1. which psychological difficulties are highlighted that can be targeted by an intervention; 2. what is important in terms of intervention content and delivery.Web-based questionnaires containing both quantitative and qualitative items were completed by people with vitiligo and HCPs. Questionnaires collected data

2018 Journal of the European Academy of Dermatology and Venereology

7. Home interventions and light therapy for the treatment of vitiligo (HI-Light Vitiligo Trial): study protocol for a randomised controlled trial. (PubMed)

Home interventions and light therapy for the treatment of vitiligo (HI-Light Vitiligo Trial): study protocol for a randomised controlled trial. Vitiligo is a condition resulting in white patches on the skin. People with vitiligo can suffer from low self-esteem, psychological disturbance and diminished quality of life. Vitiligo is often poorly managed, partly due to lack of high-quality evidence to inform clinical care. We describe here a large, independent, randomised controlled trial (RCT (...) ) assessing the comparative effectiveness of potent topical corticosteroid, home-based hand-held narrowband ultraviolet B-light (NB-UVB) or combination of the two, for the management of vitiligo.The HI-Light Vitiligo Trial is a multicentre, three-arm, parallel group, pragmatic, placebo-controlled RCT. 516 adults and children with actively spreading, but limited, vitiligo are randomised (1:1:1) to one of three groups: mometasone furoate 0.1% ointment plus dummy NB-UVB light, vehicle ointment plus NB-UVB

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2018 BMJ open

8. Automated Scoring of Vitiligo Using Superpixel-Generated Computerized Digital Image Analysis of Clinical Photographs: A Novel and Consistent Way to Score Vitiligo. (PubMed)

Automated Scoring of Vitiligo Using Superpixel-Generated Computerized Digital Image Analysis of Clinical Photographs: A Novel and Consistent Way to Score Vitiligo. 29573393 2018 08 29 1365-2133 179 1 2018 Jul The British journal of dermatology Br. J. Dermatol. Automated scoring of vitiligo using superpixel-generated computerized digital image analysis of clinical photographs: a novel and consistent way to score vitiligo. 220-221 10.1111/bjd.16563 Toh J J H JJH http://orcid.org/0000-0002-4616

2018 British Journal of Dermatology

9. Vitiligo Extent Score (VES) Score in Comparison to Vitiligo Area and Severity Index (VASI) Score

Vitiligo Extent Score (VES) Score in Comparison to Vitiligo Area and Severity Index (VASI) Score Vitiligo Extent Score (VES) Score in Comparison to Vitiligo Area and Severity Index (VASI) Score - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Vitiligo Extent Score (VES) Score in Comparison to Vitiligo Area and Severity Index (VASI) Score The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03411135 Recruitment Status : Completed First Posted : January 26, 2018 Last Update Posted : January 26, 2018 Sponsor

2018 Clinical Trials

10. International Initiative for outcomes (INFO) for vitiligo: Workshops with vitiligo patients on repigmentation. (PubMed)

International Initiative for outcomes (INFO) for vitiligo: Workshops with vitiligo patients on repigmentation. There is no cure or firm clinical recommendations for the treatment of vitiligo. One of the main issues is the heterogeneity of outcome measures used in randomized controlled trials for vitiligo.To define successful repigmentation from the patients' point of view and to propose how and when repigmentation should be evaluated in clinical trials in vitiligo.We conducted three workshops (...) with patients with vitiligo and their parents or caregivers. Workshop 1 was held at World Vitiligo Day (Detroit, MI), workshop 2 at the University of Texas Southwestern Medical Center and workshop 3 at the Vitiligo and Pigmentation Institute of Southern California, University of California.Seventy-three participants were recruited. Consensus on the following questions was achieved unanimously: (i) the definition of 'successful repigmentation' was 80-100% of repigmentation of a target lesion and (ii) both

2018 British Journal of Dermatology

11. Proteomic Analysis of the Serum of Patients with Stable Vitiligo and Progressive Vitiligo (PubMed)

Proteomic Analysis of the Serum of Patients with Stable Vitiligo and Progressive Vitiligo 29451155 2018 11 02 2018 11 13 2542-5641 131 4 2018 02 20 Chinese medical journal Chin. Med. J. Proteomic Analysis of the Serum of Patients with Stable Vitiligo and Progressive Vitiligo. 480-483 10.4103/0366-6999.225055 Li Yi-Lei YL Department of Dermatology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China. Wang Hong H Department of Bioengineering, College (...) 110001, China. Gao Xing-Hua XH Department of Dermatology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China. eng Letter China Chin Med J (Engl) 7513795 0366-6999 IM Adolescent Adult Disease Progression Female Humans Male Proteomics Vitiligo genetics pathology Young Adult There are no conflicts of interest. 2018 2 17 6 0 2018 2 17 6 0 2018 11 6 6 0 ppublish 29451155 ChinMedJ_2018_131_4_480_225055 10.4103/0366-6999.225055 PMC5830835 Pharmazie. 2014 Mar;69(3

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2018 Chinese medical journal

12. Vitiligo-like lesions occurring in patients receiving anti-programmed cell death-1 therapies are clinically and biologically distinct from vitiligo. (PubMed)

Vitiligo-like lesions occurring in patients receiving anti-programmed cell death-1 therapies are clinically and biologically distinct from vitiligo. The use of anti-programmed cell death (PD)-1 therapies in metastatic tumors is associated with cutaneous side effects including vitiligo-like lesions.We sought to characterize clinically and biologically vitiligo-like lesions occurring in patients receiving anti-PD-1 therapies by studying a case series of 8 patients with metastatic tumors and 30 (...) control subjects with vitiligo.Eight patients receiving anti-PD-1 therapies with features of vitiligo-like lesions seen in our department were recruited. Clinical features and photographs were analyzed. For some patients, skin and blood samples were obtained. Results were compared with the vitiligo group.All patients developed lesions localized on photoexposed areas with a specific depigmentation pattern consisting of multiple flecked lesions without Koebner phenomenon. In contrast to vitiligo

2017 Journal of American Academy of Dermatology

13. The Vitiligo Working Group recommendations for narrowband ultraviolet B light phototherapy treatment of vitiligo. (PubMed)

The Vitiligo Working Group recommendations for narrowband ultraviolet B light phototherapy treatment of vitiligo. Treatment of vitiligo with narrowband ultraviolet B light (NBUVB) is an important component of the current standard of care. However, there are no consistent guidelines regarding the dosing and administration of NBUVB in vitiligo, reflected by varied treatment practices around the world.To create phototherapy recommendations to facilitate clinical management and identify areas (...) requiring future research.The Vitiligo Working Group (VWG) Phototherapy Committee addressed 19 questions regarding the administration of phototherapy over 3 conference calls. Members of the Photomedicine Society and a group of phototherapy experts were surveyed regarding their phototherapy practices.Based on comparison and analysis of survey results, expert opinion, and discussion held during conference calls, expert recommendations for the administration of NBUVB phototherapy in vitiligo were

2017 Journal of American Academy of Dermatology

14. Vitiligo or Vitiligo-like Hypopigmentation Associated with Imiquimod Treatment of Condyloma Acuminatum: Not a Casual Event (PubMed)

Vitiligo or Vitiligo-like Hypopigmentation Associated with Imiquimod Treatment of Condyloma Acuminatum: Not a Casual Event 28218231 2017 03 20 2018 12 02 2542-5641 130 4 2017 02 20 Chinese medical journal Chin. Med. J. Vitiligo or Vitiligo-like Hypopigmentation Associated with Imiquimod Treatment of Condyloma Acuminatum: Not a Casual Event. 503-504 10.4103/0366-6999.199846 Long Fu-Quan FQ STD Institute, Shanghai Dermatology Hospital, Shanghai 200443, China. Zhao Li-Shi LS STD Institute (...) , Shanghai Dermatology Hospital, Shanghai 200443, China. Qian Yi-Hong YH STD Institute, Shanghai Dermatology Hospital, Shanghai 200443, China. eng Letter China Chin Med J (Engl) 7513795 0366-6999 0 Aminoquinolines P1QW714R7M Imiquimod IM Adult Aminoquinolines adverse effects therapeutic use Condylomata Acuminata drug therapy Female Humans Hypopigmentation chemically induced diagnosis Imiquimod Male Middle Aged Vitiligo chemically induced diagnosis 2017 2 21 6 0 2017 2 22 6 0 2017 3 21 6 0 ppublish

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2017 Chinese medical journal

15. Insight into Natural History of Congenital Vitiligo: A Case Report of a 23-Year-Old with Stable Congenital Vitiligo (PubMed)

Insight into Natural History of Congenital Vitiligo: A Case Report of a 23-Year-Old with Stable Congenital Vitiligo Vitiligo is a disorder of skin pigmentation. It affects approximately 1% of the world's population. Vitiligo occurs equally between the sexes with no racial predilections. The majority of cases are acquired and arise between the second and third decades of life. Acquired vitiligo has an unpredictable clinical course. Congenital vitiligo is rare with few reported cases. Due (...) to the rarity of congenital vitiligo, little is known about the clinical course. For patients with acquired or congenital vitiligo, the psychosocial burden can have a profound impact on quality of life. The unknown course of congenital vitiligo can exacerbate the feelings of distress and embarrassment. We report of a case of congenital vitiligo that has been stable for 23 years. The patient had no associated autoimmune disease. The pathogenesis of congenital vitiligo is unknown. This case may be useful

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2017 Case reports in dermatological medicine

16. Vitiligo: Patient stories, self-esteem, and the psychological burden of disease (PubMed)

Vitiligo: Patient stories, self-esteem, and the psychological burden of disease Vitiligo is a relatively common disorder that is characterized by depigmented patches of skin. Multiple studies characterize the overwhelming psychological burden that is experienced by many patients around the globe. This review examines personal patient stories and the impacts of age, culture, sex, race, and ethnicity in relationship to altered self-esteem and quality of life in patients who live with vitiligo.

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2018 International journal of women's dermatology

17. Panniculitis and vitiligo occurring during BRAF and MEK inhibitors combination in advanced melanoma patients: Potential predictive role of treatment efficacy. (PubMed)

Panniculitis and vitiligo occurring during BRAF and MEK inhibitors combination in advanced melanoma patients: Potential predictive role of treatment efficacy. Panniculitis and vitiligo-like lesions have been recently identified as rare cutaneous side effects of the combination of BRAF and MEK inhibitors, a standard of care in metastatic and locally advanced BRAF V600 mutated melanoma. An immune-mediated mechanism has been advocated in the pathogenesis of these skin lesions. Herein we (...) retrospectively reviewed our institutional experience with the aim to explore the association between the occurrence of panniculitis and vitiligo-like lesions during combination therapy with dabrafenib (D) and trametinib (T) and outcome of advanced melanoma patients. Among 52 consecutive BRAF V600 mutated melanoma patients submitted to DT in our center, 12 (23%) developed immune related skin lesions (IRSLs): 8 panniculitis and 4 vitiligo. Patients with IRSLs diagnosis obtained a better disease response (83

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2019 PLoS ONE

18. Oral minipulse therapy in vitiligo: a systematic review and meta-analysis

Oral minipulse therapy in vitiligo: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email

2019 PROSPERO

19. Development and validation of a patient-reported outcome measure in vitiligo: The Self Assessment Vitiligo Extent Score (SA-VES). (PubMed)

Development and validation of a patient-reported outcome measure in vitiligo: The Self Assessment Vitiligo Extent Score (SA-VES). The Vitiligo Extent Score (VES) has recently been introduced as a physicians' score for the clinical assessment of the extent of vitiligo, but a good patient self-assessment score is lacking.The objective is to develop and validate a simplified version of the VES as a patient-reported outcome measure (PROM).After extensive pilot testing, patients were asked to score (...) their vitiligo extent twice with an interval of 2 weeks using the Self Assessment Vitiligo Extent Score (SA-VES). The scores were compared with the physicians' evaluation (VES).The SA-VES demonstrated very good test-retest reliability (intraclass correlation = 0.948, 95% confidence interval [CI]: 0.911-0.970) that was not affected by age, skin type, or vitiligo distribution pattern. According to patients, this evaluation method was easy to use (22% very easy; 49% easy; 29% normal) and required <5 minutes

2016 Journal of American Academy of Dermatology

20. The Vitiligo Impact Patient Scale (VIPs): Development and Validation of a Vitiligo Burden Assessment Tool. (PubMed)

The Vitiligo Impact Patient Scale (VIPs): Development and Validation of a Vitiligo Burden Assessment Tool. Vitiligo has a major impact on health-related quality of life. Although a few vitiligo-specific quality of life instruments exist, there is no specific vitiligo burden tool. We developed and validated a specific vitiligo burden tool according to skin phototype. In total, 301 patients completed 35 items of the Vitiligo Impact Patient scale, of whom 235 were of skin phototype I to III and 66 (...) common to all patients, 3 specific to fair skin, and 7 to dark skin). The test-retest reliability demonstrated very good reproducibility. The intraclass correlation of each dimension was greater than 0.90 for each population. External validity was confirmed by the correlation coefficients and Bland and Altman plots of the Vitiligo Impact Patient scale-Fair Skin and Vitiligo Impact Patient scale-Dark Skin versus the Short-Form-12, PVC Metra, Body Image States Scale, and Daily Life Quality Index

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2016 Journal of Investigative Dermatology

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