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Vitamin B12 Supplementation

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141. Vitamin D supplements may reduce the chance of developing a chest infection

Vitamin D supplements may reduce the chance of developing a chest infection Vitamin D supplements may reduce the chance of developing a chest infection Discover Portal Discover Portal Vitamin D supplements may reduce the chance of developing a chest infection Published on 27 June 2017 doi: Vitamin D supplements may reduce the chances of contracting an acute respiratory tract infection, particularly for those with low existing levels of vitamin D. This NIHR-funded study pooled patient data from (...) 25 randomised controlled trials and found that daily or weekly supplements reduced respiratory tract infections compared with placebo. About 20 people would need to take regular supplements in order to prevent one infection. One-off monthly dosing gave no benefit. Public Health England (PHE) currently recommends that 10µg vitamin D is needed each day to maintain bone, teeth and muscle health. Supplements are advised for all in the winter months, and throughout the year for those who are at risk

2018 NIHR Dissemination Centre

142. Randomised controlled trial: High-dose vitamin D supplementation does not alter bone mass or muscle function over 1?year in postmenopausal women

Randomised controlled trial: High-dose vitamin D supplementation does not alter bone mass or muscle function over 1?year in postmenopausal women High-dose vitamin D supplementation does not alter bone mass or muscle function over 1 year in postmenopausal women | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our (...) . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here High-dose vitamin D supplementation does not alter bone mass or muscle function over 1 year in postmenopausal women Article Text

2016 Evidence-Based Medicine (Requires free registration)

144. Vitamin B12 supplementation during pregnancy and postpartum improves B12 status of both mothers and infants but vaccine response in mothers only: a randomized clinical trial in Bangladesh. (PubMed)

Vitamin B12 supplementation during pregnancy and postpartum improves B12 status of both mothers and infants but vaccine response in mothers only: a randomized clinical trial in Bangladesh. Poor vitamin B12 (B12) status is associated with adverse outcomes in pregnancy and infancy. Little is known about effects of B12 supplementation on immune function. The present study aimed to evaluate effects of pre- and postnatal B12 supplementation on biomarkers of B12 status and vaccine-specific responses (...) , B12, methylmalonic acid (MMA), total homocysteine (tHcy), ferritin and serum transferrin receptor, C-reactive protein (CRP) and alpha-1-acid glycoprotein (AGP). Vitamin B12 was also assessed in breast milk. H1N1-specific antibodies were determined in plasma and colostrum/breast milk.At baseline, 26% women were B12 deficient (<150 pmol/L), 40% had marginal status (150-220 pmol/L), 43% had elevated MMA (>271 nmol/L), and 31% had elevated tHcy (>10 μmol/L). Supplementation increased B12 in plasma

2015 European journal of nutrition Controlled trial quality: uncertain

145. Vitamin D supplementation in pregnancy: a systematic review

Vitamin D supplementation in pregnancy: a systematic review Vitamin D supplementation in pregnancy: A systematic review Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title

2014 NIHR HTA programme

146. Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial. (PubMed)

Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial. Clinical trials are scant and equivocal on whether vitamin D can ameliorate arterial stiffness, particularly in populations at high risk for vitamin D deficiency and cardiovascular disease (CVD). This study determined the dose-response effects of vitamin D3 supplementation on arterial stiffness in overweight African Americans (...) with vitamin D deficiency.Seventy overweight African Americans (aged 13-45 years) with serum 25-hydroxyvitamin D [25(OH)D] levels ≤ 20 ng/mL were randomized to monthly oral supplementation of 18,000 IU (~600 IU/day, n = 17), 60,000 IU (~2000 IU/day, n = 18), or 120,000 IU (~4000 IU/day, n = 18) of vitamin D3 or placebo (n = 17) for 16-weeks. The arterial stiffness measurements, carotid-femoral pulse wave velocity (PWV) and carotid-radial PWV, were assessed by applanation tonometry at baseline and 16

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2017 PLoS ONE Controlled trial quality: uncertain

147. Vitamin B complex and vitamin B12 levels after peripheral nerve injury (PubMed)

in the injured sciatic nerve was significantly lower at 1, 6, 12 and 24 hours than in the control group. These results suggest that tissue levels of vitamin B complex and vitamin B12 vary with progression of crush-induced peripheral nerve injury, and supplementation of these vitamins in the acute period may be beneficial for acceleration of nerve regeneration. (...) Vitamin B complex and vitamin B12 levels after peripheral nerve injury The aim of the present study was to evaluate whether tissue levels of vitamin B complex and vitamin B12 were altered after crush-induced peripheral nerve injury in an experimental rat model. A total of 80 male Wistar rats were randomized into one control (n = 8) and six study groups (1, 6, 12, 24 hours, 3, and 7 days after experimental nerve injury; n = 12 for each group). Crush-induced peripheral nerve injury was performed

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2016 Neural Regeneration Research

148. Protective effect of vitamin C, vitamin B12 and omega-3 on lead-induced memory impairment in rat (PubMed)

Protective effect of vitamin C, vitamin B12 and omega-3 on lead-induced memory impairment in rat Lead belongs to the heavy metal group and is considered as an environmental contaminant. Acute or chronic contact to lead can change the physiological function of human organs. One of the most important disorders following the lead exposure is neurotoxicity. Lead neurotoxicity consists of the neurobehavioral disturbances like cognitive impairment. The aim of the current study is to evaluate (...) the possible protective effect of vitamin C (Vit C), vitamin B12 (Vit B12), omega 3 (ω-3), or their combination on the lead-induced memory disorder. Adult wistar rats were orally administered Vit C (120 mg/kg/day) or Vit B12 (1 mg/kg/day) or ω-3 (1000 mg/kg/day) or their combination for 3 weeks in groups of 7 animals each. Then lead acetate (15 mg/kg/day) was injected intraperitoneally for one week to all pretreated animals. The control group received normal saline as a vehicle while the positive control

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2016 Research in pharmaceutical sciences

149. Effect of Folic Acid, Betaine, Vitamin B₆, and Vitamin B12 on Homocysteine and Dimethylglycine Levels in Middle-Aged Men Drinking White Wine. (PubMed)

the most effective way of decreasing homocysteine during moderate alcohol consumption.Male volunteers (n = 117) were randomly divided into five groups: the wine-only group (control, 375 mL of white wine daily for one month) and four groups combining wine consumption with one of the supplemented substances (folic acid, betaine, and vitamins B12 or B₆). Significant lowering of homocysteine concentration after the drinking period was found in subjects with concurrent folate and betaine supplementation (...) . Vitamin B12 and vitamin B₆ supplementation did not lead to a statistically significant change in homocysteine. According to a multiple linear regression model, the homocysteine change in the wine-only group was mainly determined by the interaction between the higher baseline homocysteine concentration and the change in dimethylglycine levels. Folate and betaine can attenuate possible adverse effects of moderate alcohol consumption. Dimethylglycine should be interpreted together with data on alcohol

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2016 Nutrients Controlled trial quality: uncertain

150. Folic Acid, Vitamin B6, and Vitamin B12 in Combination and Age-Related Cataract in a Randomized Trial of Women. (PubMed)

of CVD, daily supplementation with a combination of folic acid, vitamin B6, and vitamin B12 had no significant effect on cataract, but may have increased the risk of cataract extraction. (...) Folic Acid, Vitamin B6, and Vitamin B12 in Combination and Age-Related Cataract in a Randomized Trial of Women. To examine the incidence of cataract and cataract extraction in a trial of folic acid and vitamins B6 and B12.In a randomized, double-masked, placebo-controlled trial, 5442 female health professionals aged 40 years or older with preexisting cardiovascular disease (CVD) or three or more CVD risk factors were randomly assigned to receive a combination of folic acid (2.5 mg/day), vitamin

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2016 Ophthalmic epidemiology Controlled trial quality: predicted high

151. Vitamin D Supplementation, Glycemic Control, and Insulin Resistance in Prediabetics: A Meta-Analysis (PubMed)

Vitamin D Supplementation, Glycemic Control, and Insulin Resistance in Prediabetics: A Meta-Analysis Diabetes prevention is a public health priority. Vitamin D supplementation may help prevent the development of diabetes in persons at increased risk. We performed a meta-analysis of controlled clinical trials that assessed glycemic outcome measures among adults at risk for type 2 diabetes, including prediabetes, overweight, or obesity. We searched PUBMED/ MEDLINE, CINAHL, and Google Scholar (...) databases for trials published prior to April 2017. Placebo-controlled clinical trials with random allocation to vitamin D with or without calcium supplementation were selected. Data collection included country, study design, inclusion criteria, sample size, form, and dose of vitamin D, supplementation interval, control group, duration, participant characteristics, comorbidities, baseline and follow-up serum 25-hydroxyvitamin D [25(OH)D] concentration, and available outcome measures [glycosylated

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2018 Journal of the Endocrine Society

152. Vitamin D Supplementation, Serum 25(OH)D Concentrations and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis (PubMed)

Vitamin D Supplementation, Serum 25(OH)D Concentrations and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis Background: Cardiovascular disease (CVD) risk factors are associated with low serum 25 hydroxyvitamin D (25(OH)D) concentrations in observational studies; however, clinical trial findings are inconsistent. Objective: We assessed the effect of vitamin D supplementation and increased serum 25(OH)D concentrations on CVD risk factors in a systemic review and meta (...) -analysis of randomized controlled trials (RCTs). Design: MEDLINE, CINAHL, EMBASE, and Google Scholar were searched for RCTs that evaluated vitamin D supplementation and cardiovascular outcomes [blood pressure, parathyroid hormone (PTH), serum high-sensitivity C-reactive protein (hs-CRP), total cholesterol, high and low density lipoprotein (HDL and LDL, respectively), triglycerides, peak wave velocity (PWV) and Augmentation Index (AI)] from 1992 through 2017. Meta-analysis was based on a random-effects

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2018 Frontiers in cardiovascular medicine

153. Effect of vitamin D supplementation on upper and lower limb muscle strength and muscle power in athletes: A meta-analysis. (PubMed)

Effect of vitamin D supplementation on upper and lower limb muscle strength and muscle power in athletes: A meta-analysis. Vitamin D may play a role in skeletal muscle because of the discovery of VDR in skeletal muscle. However, vitamin D deficiency is a global problem, including athletes. Studies examining the effect of vitamin D supplementation on muscle function in athletes have inconsistent results. Therefore, we aimed to quantitatively summarize the evidence for the effect of vitamin D (...) identified by regression analysis. The potential publication and sensitivity analyses were also assessed.Eight RCTs involving 284 athletes were included. The protocols used to evaluate the muscle strength of athletes were inconsistent across the included studies, and muscle explosive power was assessed via vertical jump tests. The results indicated that vitamin D supplementation had no impact on overall muscle strength outcomes (SMD 0.05, 95% CI: -0.39 to 0.48, p = 0.84). In subgroup analysis, vitamin D

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2019 PLoS ONE

154. Efficacy of vitamin D supplementation in gestational diabetes mellitus: Systematic review and meta-analysis of randomized trials. (PubMed)

Efficacy of vitamin D supplementation in gestational diabetes mellitus: Systematic review and meta-analysis of randomized trials. Trials have examined on the benefits of vitamin D supplementation in pregnant women.This review aimed to evaluate whether oral vitamin D supplements, when given to pregnant women with gestational diabetes mellitus (GDM), would improve maternal and neonatal outcomes, compared with no treatment or placebo.We performed a systematic review following Cochrane methodology (...) , and randomized trials were included where pregnant women with GDM received vitamin D supplementation versus placebo/no treatment or vitamin D and calcium versus placebo/no treatment. Primary outcomes were preeclampsia, preterm birth, cesarean delivery, gestational hypertension, and adverse events related to vitamin D supplementation. The search strategies were applied to the following databases: MEDLINE, Embase, LILACS, and CENTRAL. Similar outcomes in at least two trials were plotted using Review Manager

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2019 PLoS ONE

155. Is there any evidence for the use of vitamin B12 supplements/oral or injection in the management of Multiple Sclerosis in the presence of normal vitamin B12 levels? Is there harm from over use of v

Is there any evidence for the use of vitamin B12 supplements/oral or injection in the management of Multiple Sclerosis in the presence of normal vitamin B12 levels? Is there harm from over use of v Is there any evidence for the use of vitamin B12 supplements/oral or injection in the management of Multiple Sclerosis in the presence of normal vitamin B12 levels? Is there harm from over use of vitamin B12. - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title (...) @tripdatabase.com Is there any evidence for the use of vitamin B12 supplements/oral or injection in the management of Multiple Sclerosis in the presence of normal vitamin B12 levels? Is there harm from over use of vitamin B12. ATTRACT found one previously answered query (2008) on the use of B12 in multiple sclerosis (1) in TRIPanswers. This has not identified any robust evidence to support the use of B12 in multiple sclerosis. A search of the literature from 2008 to the present has not yielded any randomized

2011 TRIP Answers

156. Vitamin B12 for Aromatase Inhibitors Musculoskeletal Symptoms

. Vitamin B12, whether as injection or oral forms, has been used as a naturopathic product to provide relief for joint pain caused by arthritis. This effect has not been studied in the setting of Aromatase Inhibitor-Associated Musculoskeletal Symptoms (AIMSS). Condition or disease Intervention/treatment Phase Relief of Joint Pain Dietary Supplement: Vitamin B12 Not Applicable Detailed Description: Primary Objectives: a. To assess whether daily oral Vitamin B12 decreases average joint pain in women (...) Stage Breast Cancer Actual Study Start Date : October 19, 2015 Actual Primary Completion Date : October 27, 2016 Actual Study Completion Date : October 27, 2016 Resource links provided by the National Library of Medicine related topics: related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Arm I Oral Vitamin B12 Dietary Supplement: Vitamin B12 Vitamin B12 2500 micrograms sublingually per day over the course of 90 days (+/- 10 days) Outcome Measures Go

2017 Clinical Trials

157. Associations of Maternal Vitamin B12 Concentration in Pregnancy With the Risks of Preterm Birth and Low Birth Weight: A Systematic Review and Meta-Analysis of Individual Participant Data. (PubMed)

(adjusted risk ratio = 1.15, 95% confidence interval (CI): 1.01, 1.31). There was a linear association between maternal levels of B12 and preterm birth (per each 1-standard-deviation increase in B12, adjusted risk ratio = 0.89, 95% CI: 0.82, 0.97). Accordingly, B12 deficiency was associated with a higher risk of preterm birth (adjusted risk ratio = 1.21, 95% CI: 0.99, 1.49). This finding supports the need for randomized controlled trials of vitamin B12 supplementation in pregnancy.© The Author 2017 (...) Associations of Maternal Vitamin B12 Concentration in Pregnancy With the Risks of Preterm Birth and Low Birth Weight: A Systematic Review and Meta-Analysis of Individual Participant Data. Vitamin B12 (hereafter referred to as B12) deficiency in pregnancy is prevalent and has been associated with both lower birth weight (birth weight <2,500 g) and preterm birth (length of gestation <37 weeks). Nevertheless, current evidence is contradictory. We performed a systematic review and a meta-analysis

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2017 American Journal of Epidemiology

158. High folate and low vitamin B12 status during pregnancy is associated with gestational diabetes mellitus. (PubMed)

adjusting for other B-vitamins.Higher maternal folate coupled with vitamin B12 insufficiency was associated with higher GDM risk. This finding has potential implications for antenatal supplement recommendations but will require confirmation in future studies.Copyright © 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. (...) High folate and low vitamin B12 status during pregnancy is associated with gestational diabetes mellitus. B-vitamins and homocysteine may contribute to the development of gestational diabetes mellitus (GDM), but existing studies are inconsistent. We examined the cross-sectional associations of plasma folate, vitamins B6, B12, and homocysteine concentrations with GDM and glycemia in a sample of multi-ethnic Asian pregnant women.Plasma concentrations of folate, vitamins B6, B12, homocysteine

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2017 Clinical nutrition (Edinburgh, Scotland)

159. Associations between Folate and Vitamin B12 Levels and Inflammatory Bowel Disease: A Meta-Analysis. (PubMed)

supplements of folate and vitamin B12 to IBD patients may improve their nutritional status and prevent other diseases. (...) Associations between Folate and Vitamin B12 Levels and Inflammatory Bowel Disease: A Meta-Analysis. Inflammatory bowel disease (IBD) patients may be at risk of vitamin B12 and folate insufficiencies, as these micronutrients are absorbed in the small intestine, which is affected by IBD. However, a consensus has not been reached on the association between IBD and serum folate and vitamin B12 concentrations.In this study, a comprehensive search of multiple databases was performed to identify

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2017 Nutrients

160. The Impact of Vitamin B12 Deficiency on Infant Gut Microbiota

withdrawal. For the reporting, serum vitamin B12 <203 pg/mL is considered as vitamin B12 deficiency, and ≥203 pg/mL as vitamin B12 sufficient. Infants with vitamin B12 deficiency are treated with intramuscular vitamin b12 (hydroxycobalamin), 250-500 mcg twice weekly for a week, and then 500 mcg weekly for another 3 weeks. One month after the supplementation in the recommended dose, stools are recollected in a subgroup of subjects (n=11) with vitamin B12 deficiency. Samples are kept at 4 C and in less (...) The Impact of Vitamin B12 Deficiency on Infant Gut Microbiota The Impact of Vitamin B12 Deficiency on Infant Gut Microbiota - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Impact of Vitamin B12

2017 Clinical Trials

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