How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

22,475 results for

Vitamin B12 Supplementation

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

21. Vitamin A and beta (β)-carotene supplementation for cystic fibrosis. Full Text available with Trip Pro

Vitamin A and beta (β)-carotene supplementation for cystic fibrosis. People with cystic fibrosis (CF) and pancreatic insufficiency are at risk of a deficiency in fat-soluble vitamins, including vitamin A. Vitamin A deficiency predominantly causes eye and skin problems, while excessive levels of vitamin A can harm the respiratory and skeletal systems in children and interfere with the metabolism of other fat-soluble vitamins. Most CF centres administer vitamin A as supplements to reduce (...) the frequency of vitamin A deficiency in people with CF and to improve clinical outcomes such as growth, although the recommended dose varies between different guidelines. Thus, a systematic review on vitamin A and vitamin A-like supplementation (carotenes or other retinoids) in people with CF would help guide clinical practice. This is an update of an earlier Cochrane Review.To determine if supplementation with vitamin A, carotenes or other retinoid supplements in children and adults with CF reduces

2018 Cochrane

22. Dietary Intake of Vitamin B12 is Better for Restoring a Low B12 Status Than a Daily High-Dose Vitamin Pill: An Experimental Study in Rats Full Text available with Trip Pro

Dietary Intake of Vitamin B12 is Better for Restoring a Low B12 Status Than a Daily High-Dose Vitamin Pill: An Experimental Study in Rats Vitamin B12 (B12) is present in foods of animal origin, and vegans are encouraged to take supplements with synthetic B12 in order to ensure a sufficient uptake. Recent rat studies suggest that natural (hydroxo-B12, HO-B12) and synthetic (cyano-B12, CN-B12) B12 behave differently in the body. Here, we test if a daily vitamin pill matches dietary B12 in ability (...) to restore a low B12 status in rats. B12-depleted male Wistar rats (n = 60) were divided into five groups (n = 12 in each) and subjected to two weeks intervention with various schemes of B12 supplementation. Two "dietary" groups received a low-B12 chow that was fortified with either HO-B12 or CN-B12 providing a continuous supply. Two "pill" groups received a single daily dose of CN-B12, where the vitamin content either matched or exceeded by factor four the provisions for the "dietary" groups. A control

2018 Nutrients

23. Calcium and Vitamin D Supplementation for Adults: Safety and Guidelines

Calcium and Vitamin D Supplementation for Adults: Safety and Guidelines Calcium and Vitamin D Supplementation for Adults: Safety and Guidelines | CADTH.ca Find the information you need Calcium and Vitamin D Supplementation for Adults: Safety and Guidelines Calcium and Vitamin D Supplementation for Adults: Safety and Guidelines Last updated: June 7, 2018 Project Number: RB1229-000 Product Line: Research Type: Drug Report Type: Summary of Abstracts Result type: Report Question What (...) is the clinical evidence for the safety of calcium and vitamin D supplementation in adults? What are the evidence-based guidelines regarding the use of calcium and vitamin D supplements in the general adult population? Key Message Thirteen systematic reviews (seven with meta-analyses), 30 randomized controlled trials, and seven evidence based guidelines were identified regarding calcium and vitamin D supplementation in adults. Files Rapid Response Summary of Abstracts Published : June 7, 2018 Related Content

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

24. Vitamin D Supplementation for the General Population: Clinical Evidence and Guidelines

Vitamin D Supplementation for the General Population: Clinical Evidence and Guidelines Vitamin D Supplementation for the General Population: Clinical Evidence and Guidelines | CADTH.ca Find the information you need Vitamin D Supplementation for the General Population: Clinical Evidence and Guidelines Vitamin D Supplementation for the General Population: Clinical Evidence and Guidelines Last updated: November 7, 2018 Project Number: RB1274-000 Product Line: Research Type: Drug Report Type (...) : Summary of Abstracts Result type: Report Question What is the clinical evidence regarding routine vitamin D supplementation in the general population? What are the evidence-based guidelines regarding vitamin D supplementation in the general population? Key Message Ten systematic reviews with meta-analyses and one evidence-based guideline were identified regarding vitamin d supplementation for the general population. No evidence-based guidelines were identified. Files Rapid Response Summary

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

27. Comparative Bioavailability of Synthetic B12 and Dietary Vitamin B12 Present in Cow and Buffalo Milk: A Prospective Study in Lactovegetarian Indians. Full Text available with Trip Pro

Comparative Bioavailability of Synthetic B12 and Dietary Vitamin B12 Present in Cow and Buffalo Milk: A Prospective Study in Lactovegetarian Indians. We assessed improvements in the vitamin B12 status of Indian lactovegetarians receiving four weeks supplementation with natural B12 in milk versus cyano-B12 in capsules. Three groups (n = 22, 23, 22) received daily oral doses of cyano-B12 (2 × 0.76 µg) or milk (2 × 200 mL) from a cow or buffalo (amounting to B12 ≈ 2 × 0.76 µg). Their blood (...) was examined at baseline and each following week. The baselines (median (min/max)) indicated a low B12 status: plasma B12 (116(51/314)) pmol/L, holotranscobalamin (holoTC) (30(7/119)) pmol/L, total homocysteine (Hcy) (24(10/118)) µmol/L, methylmalonic acid (MMA) (0.58(0.15/2.2)) µmol/L and combined B12 index (cB12) (-1.32 - (-3.12/+0.29)). Shifts from the baselines (B12, holoTC, cB12) and ratios to the baselines (Hcy, MMA) were analyzed over time. The cyano-B12 treatment gave more total B12 in plasma

2019 Nutrients Controlled trial quality: uncertain

28. Supplementation with vitamin D plus calcium reduces fracture risk; vitamin D alone does not. (Abstract)

Supplementation with vitamin D plus calcium reduces fracture risk; vitamin D alone does not. Yao P, Bennett D, Mafham M, et al. Vitamin D and calcium for the prevention of fracture: a systematic review and meta-analysis. JAMA Netw Open. 2019;2:e1917789. 31860103.

2020 Annals of Internal Medicine

29. Vitamin K supplementation for cystic fibrosis. Full Text available with Trip Pro

Vitamin K supplementation for cystic fibrosis. Cystic fibrosis is a genetic disorder which can lead to multiorgan dysfunction. Malabsorption of fat and fat-soluble vitamins (A, D, E, K) may occur and can cause subclinical deficiencies of some of these vitamins. Vitamin K is known to play an important role in both blood coagulation and bone formation. Supplementation with vitamin K appears to be one way of addressing the deficiency, but there is very limited agreement on the appropriate dose (...) and frequency of use of these supplements. This is an updated version of the review.To assess the effects of vitamin K supplementation in people with cystic fibrosis and to determine the optimal dose and route of administration of vitamin K for both routine and therapeutic use.We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group's Trials Register comprising references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books

2017 Cochrane

30. Vitamin D supplementation for sickle cell disease. Full Text available with Trip Pro

Vitamin D supplementation for sickle cell disease. Sickle cell disease is a genetic chronic haemolytic and pro-inflammatory disorder. The clinical manifestations of sickle cell disease result from the presence of mutations on the beta globin genes that generate an abnormal haemoglobin product (called haemoglobin S) within the red blood cell. Sickle cell disease can lead to many complications such as acute chest syndrome, stroke, acute and chronic bone complications (including painful vaso (...) and the safety of vitamin D supplementation in sickle cell disease.To investigate the hypothesis that vitamin D supplementation increases serum 25-hydroxyvitamin D level in children and adults with sickle cell disease.To determine the effects of vitamin D supplementation on general health such as growth status and health-related quality of life; on musculoskeletal health including bone mineral density, pain crises, bone fracture and muscle health; on respiratory health which includes lung function tests

2017 Cochrane

31. Randomized controlled trial: Maternal postpartum high-dose vitamin D3 supplementation (6400?IU/day) or conventional infant vitamin D3 supplementation (400?IU/day) lead to similar vitamin D status of healthy exclusively/fully breastfeeding infants by 7?mon

Randomized controlled trial: Maternal postpartum high-dose vitamin D3 supplementation (6400?IU/day) or conventional infant vitamin D3 supplementation (400?IU/day) lead to similar vitamin D status of healthy exclusively/fully breastfeeding infants by 7?mon Maternal postpartum high-dose vitamin D3 supplementation (6400 IU/day) or conventional infant vitamin D3 supplementation (400 IU/day) lead to similar vitamin D status of healthy exclusively/fully breastfeeding infants by 7 months of age | BMJ (...) OR managers of institutional accounts Username * Password * your user name or password? You are here Maternal postpartum high-dose vitamin D3 supplementation (6400 IU/day) or conventional infant vitamin D3 supplementation (400 IU/day) lead to similar vitamin D status of healthy exclusively/fully breastfeeding infants by 7 months of age Article Text Therapeutics/Prevention Randomized controlled trial Maternal postpartum high-dose vitamin D3 supplementation (6400 IU/day) or conventional infant vitamin D3

2016 Evidence-Based Medicine

32. Vitamin D supplements during gestation and wheezing in childhood: we need more evidence

Vitamin D supplements during gestation and wheezing in childhood: we need more evidence Suplementos de vitamina D en la gestación y sibilancias en la infancia: necesitamos más pruebas - Evidencias en pediatría Ochoa Sangrador C, Andrés de Llano JM. Suplementos de vitamina D en la gestación y sibilancias en la infancia: necesitamos más pruebas. Evid Pediatr. 2017;13:23. " /> Buscando, por favor espere. Mostrar menú Gestión de biblioteca Aún no ha añadido ningún artículo a su biblioteca. | Buscar

2017 Evidencias en Pediatría

33. Iron, Zinc, and Vitamin D Supplementation During Breastfeeding

Iron, Zinc, and Vitamin D Supplementation During Breastfeeding ABM Protocol ABM Clinical Protocol #29: Iron, Zinc, and Vitamin D Supplementation During Breastfeeding Sarah N. Taylor and The Academy of Breastfeeding Medicine A central goal of The Academy of Breastfeeding Medicine is the development of clinical protocols, free from commercial interest or in?uence, for managing common medical problems that may impact breastfeeding success. These protocols serve only as guidelines for the care (...) such as prematurity. In contemporary high- and low- resource settings, concern has been raised regarding iron, zinc, and vitamin D status of human milk-fed infants. This protocolreviewstheavailableevidenceregardingiron,zinc, and vitamin D supplementation of the breastfeeding dyad. Quality of evidence (levels of evidence [LOE] IA, IB, IIA, IIB, III, and IV) is provided and based on levels of evidence used for the National Guidelines Clearing House. 1 From currentlyavailable evidence,recommendationsareprovided

2018 Academy of Breastfeeding Medicine

34. Vitamin D, Calcium, or Combined Supplementation for the Primary Prevention of Fractures in Community-Dwelling Adults: Preventive Medication

Vitamin D, Calcium, or Combined Supplementation for the Primary Prevention of Fractures in Community-Dwelling Adults: Preventive Medication Recommendation | United States Preventive Services Taskforce Toggle navigation Main navigation Main navigation Recommendation Postmenopausal women The USPSTF recommends against daily supplementation with 400 IU or less of vitamin D and 1000 mg or less of calcium for the primary prevention of fractures in community-dwelling, postmenopausal women. D Men (...) and premenopausal women The USPSTF concludes that the current evidence is insufficient to assess the balance of the benefits and harms of vitamin D and calcium supplementation, alone or combined, for the primary prevention of fractures in men and premenopausal women. I Postmenopausal women The USPSTF concludes that the current evidence is insufficient to assess the balance of the benefits and harms of daily supplementation with doses greater than 400 IU of vitamin D and greater than 1000 mg of calcium

2018 U.S. Preventive Services Task Force

35. The effects of vitamin B12 supplementation in pregnancy and postpartum on growth and neurodevelopment in early childhood: Study Protocol for a Randomized Placebo Controlled Trial. Full Text available with Trip Pro

The effects of vitamin B12 supplementation in pregnancy and postpartum on growth and neurodevelopment in early childhood: Study Protocol for a Randomized Placebo Controlled Trial. Vitamin B12 is crucial for normal cell division and differentiation, and necessary for the development and myelination of the central nervous system. Pregnant mothers in resource poor settings are at risk for poor vitamin B12 status. Poor vitamin B12 status in infancy is linked to poor growth and neurodevelopment (...) . Brain development starts from conception, and pregnancy is a period of rapid growth and development for the brain.The study is an individually randomised double-blind placebo controlled trial in 800 pregnant Nepalese women randomised in a 1:1 ratio. A daily dose of 50 µg of vitamin B12 or placebo is given to women from early pregnancy, not later than week 15, until 6 months after birth. Weekly visits are conducted in order to record compliance, growth and morbidity. The primary outcomes are scores

2017 BMJ open Controlled trial quality: predicted high

36. Periconceptional folic acid supplementation and vitamin B12 status in a cohort of Chinese early pregnancy women with the risk of adverse pregnancy outcomes Full Text available with Trip Pro

Periconceptional folic acid supplementation and vitamin B12 status in a cohort of Chinese early pregnancy women with the risk of adverse pregnancy outcomes Maternal folate and vitamin B12 deficiency predict poor pregnancy outcome. To improve pregnancy outcomes in rural area of China, we investigate rural women's folic acid supplementation (FAS) status and the associations between maternal vitamin B status during the first trimester and subsequent adverse pregnancy outcomes. We collected (...) the questionnaire information and drew 5 ml of blood from 309 early pregnant rural women. The birth outcomes were retrieved from medical records after delivery. Out of the total, 257 had taken FAS, including 50 before conception (group A) and 207 during the first trimester (group B). The concentration of plasma folate and the RBC folate supplementation groups were obviously higher than that of no-supplementation group (group N, p<0.01). The mean vitamin B12 levels in FAS group were significantly higher than

2017 Journal of clinical biochemistry and nutrition

37. Food-Like Growth Conditions Support Production of Active Vitamin B12 by Propionibacterium freudenreichii 2067 without DMBI, the Lower Ligand Base, or Cobalt Supplementation Full Text available with Trip Pro

Food-Like Growth Conditions Support Production of Active Vitamin B12 by Propionibacterium freudenreichii 2067 without DMBI, the Lower Ligand Base, or Cobalt Supplementation Propionibacterium freudenreichii is a traditional dairy bacterium and a producer of short chain fatty acids (propionic and acetic acids) as well as vitamin B12. In food applications, it is a promising organism for in situ fortification with B12 vitamin since it is generally recognized as safe (GRAS) and it is able (...) to synthesize biologically active form of the vitamin. In the present study, vitamin B12 and pseudovitamin biosynthesis by P. freudenreichii was monitored by UHPLC as a function of growth in food-like conditions using a medium mimicking cheese environment, without cobalt or 5,6-dimethylbenzimidazole (DMBI) supplementation. Parallel growth experiments were performed in industrial-type medium known to support the biosynthesis of vitamin B12. The production of other key metabolites in the two media were

2017 Frontiers in microbiology

38. The effect of vitamin B12 supplementation in Nepalese infants on growth and development: study protocol for a randomized controlled trial Full Text available with Trip Pro

The effect of vitamin B12 supplementation in Nepalese infants on growth and development: study protocol for a randomized controlled trial Vitamin B12 deficiency is one of the most common micronutrient deficiencies and is associated with poor cognitive development and growth. Vitamin B12 is crucial for normal cell division and differentiation, and it is necessary for the development and myelination of the central nervous system. The aim of the present study is to measure the effect of daily (...) supplementation of vitamin B12 on the neurodevelopment and growth of young children in Nepal.We are conducting an individually randomized, double-blind, placebo-controlled trial with 600 marginally stunted children 6-11 months old (length for age less than -1 z-score). Children are randomized to receive a lipid-based paste containing vitamin B12 or placebo daily for 12 months. The main outcomes are changes in growth (z-scores) and in neurodevelopment measured by the Bayley Scales of Infant and Toddler

2017 Trials Controlled trial quality: predicted high

39. The C677T MTHFR genotypes influence the efficacy of B9 and B12 vitamins supplementation to lowering plasma total homocysteine in hemodialysis. (Abstract)

The C677T MTHFR genotypes influence the efficacy of B9 and B12 vitamins supplementation to lowering plasma total homocysteine in hemodialysis. Hyperhomocysteinaemia, an independent risk factor for cardiovascular diseases, is common in hemodialysis patients (HD) and particularly in those homozygous for polymorphism of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene. B vitamins supplementation has been shown to lower plasma total homocysteine (tHcy), but this has been contreversed (...) in several groups. The aim of our study was to explore the response of tHcy in hemodialysis (HD) patients to individual supplementation with folic acid (B9) and/or vitamin B12, based on carrier status for the (MTHFR) polymorphism.132HD were randomized according to C677TMTHFR genotypes into 2 groups (AandB). The group (A) was treated initially with B9 (10mg/day orally) for 2 months (t1) and then with B12 vitamin (cyanocobalamin ampoule of 1000 μg) for the following 2 months (t2), then association of B9

2017 Journal of nephrology Controlled trial quality: uncertain

40. Vitamin B12 Supplementation During Pregnancy on Cognitive Development

Vitamin B12 Supplementation During Pregnancy on Cognitive Development Vitamin B12 Supplementation During Pregnancy on Cognitive Development - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Vitamin B12 (...) decrease absorption. Vitamin B12 is crucial for normal cell division and differentiation, and necessary for the development and myelination of the central nervous system. Deficiency is also associated with impaired fetal and infant growth. In the proposed study we will measure the effect of daily oral vitamin B12 supplementation to pregnant women on neurodevelopment and growth of their children. We also aim to measure the impact of B12 supplementation on several other outcomes. Study design

2017 Clinical Trials

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>