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Vitamin B12 Supplementation

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21. Vitamin B12 Supplementation to Improve B12 Status and Child Development

Vitamin B12 Supplementation to Improve B12 Status and Child Development Vitamin B12 Supplementation to Improve B12 Status and Child Development - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Vitamin B12 (...) . The investigators hypothesize that prolonged vitamin B12 supplementation through fortified milk starting from early pregnancy up to 6 mo-postpartum will improve: (1) biomarkers of vitamin B12 status in mothers-infant pairs (2) vaccine specific adaptive immunity in infants; (3) neurological and cognitive function in infants. Condition or disease Intervention/treatment Phase Early Pregnancy Dietary Supplement: Vitamin B12 fortified UHT milk Dietary Supplement: Plain UHT milk Not Applicable Detailed Description

2017 Clinical Trials

22. Vitamin D Supplementation for the Prevention of Falls and Fractures in Residents of Long-Term Care Facilities: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines

Vitamin D Supplementation for the Prevention of Falls and Fractures in Residents of Long-Term Care Facilities: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines Vitamin D Supplementation for the Prevention of Falls and Fractures in Residents of Long-Term Care Facilities: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines | CADTH.ca Find the information you need Vitamin D Supplementation for the Prevention of Falls and Fractures in Residents of Long-Term (...) Care Facilities: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines Vitamin D Supplementation for the Prevention of Falls and Fractures in Residents of Long-Term Care Facilities: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines Last updated: April 30, 2019 Project Number: RC1105-000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of vitamin D supplementation

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

23. Nutritional interventions update: vitamin D supplements during pregnancy

Nutritional interventions update: vitamin D supplements during pregnancy For more information, please contact: Department of Reproductive Health and Research World Health Organization 20 Avenue Appia, 1211 Geneva 27 Switzerland Fax: +41 22 791 4171 Email: reproductivehealth@who.int Website: www.who.int/reproductivehealth Department of Maternal, Newborn, Child and Adolescent Health World Health Organization 20 Avenue Appia, 1211 Geneva 27 Switzerland T el. +41 22 791 3281 Fax: +41 22 791 4853 (...) Email: mncah@who.int Website: www.who.int/maternal_child_adolescent Department of Nutrition for Health and Development World Health Organization 20 Avenue Appia, 1211 Geneva 27 Switzerland Fax: +41 22 791 4156 Email: nutrition@who.int WHO antenatal care recommendations for a positive pregnancy experience Nutritional interventions update: Vitamin D supplements during pregnancyWHO antenatal care recommendations for a positive pregnancy experience Nutritional interventions update: Vitamin D supplements

2020 World Health Organisation Guidelines

24. Effect of Maternal Vitamin B12 Supplementation on Cognitive Outcomes in South Indian Children: A Randomized Controlled Clinical Trial. (Abstract)

Effect of Maternal Vitamin B12 Supplementation on Cognitive Outcomes in South Indian Children: A Randomized Controlled Clinical Trial. Objectives To examine the effects of oral maternal vitamin B12 supplementation during pregnancy and early lactation on cognitive development in children. Method We studied 218 children born to mothers enrolled in a placebo-controlled, randomized trial of vitamin B12 supplementation during pregnancy through 6 weeks post-partum. Cognitive functions were assessed (...) received oral vitamin B12 supplementation had significantly higher scores on expressive language compared to children of mothers who received placebo (β = 0.14, P = 0.03). Children of mothers with elevated serum total homocysteine (tHcy) in the second and third trimesters of pregnancy had significantly lower scores on expressive language (β = - 0.18, P = 0.03 and β = - 0.19, P = 0.02, respectively) and gross motor domains (β = - 0.23, P = 0.008 and β = - 0.30, P = 0.001, respectively) of BSID-III

2018 Maternal and child health journal Controlled trial quality: uncertain

25. Vitamin B12 Pregnancy Supplementation

Vitamin B12 Pregnancy Supplementation Vitamin B12 Pregnancy Supplementation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Vitamin B12 Pregnancy Supplementation The safety and scientific validity (...) Health Organisation) since 1959, and this recommendation was confirmed by numerous professional associations. However, in women with anemia, or women subjected to particular dietary regimens with diminished quantity of iron, including vegetarian or vegan diet, required supplementation dosage is higher, and estimated in the literature to be 120 mg/day. The aim of this study was to analyze whether adding vitamin B12 (5 µg /100 days), along with folic acid and iron as supplement in pregnant women who

2018 Clinical Trials

26. Population Reference Values for Serum Methylmalonic Acid Concentrations and Its Relationship with Age, Sex, Race-Ethnicity, Supplement Use, Kidney Function and Serum Vitamin B12 in the Post-Folic Acid Fortification Period Full Text available with Trip Pro

Population Reference Values for Serum Methylmalonic Acid Concentrations and Its Relationship with Age, Sex, Race-Ethnicity, Supplement Use, Kidney Function and Serum Vitamin B12 in the Post-Folic Acid Fortification Period Serum methylmalonic acid (MMA) is elevated in vitamin B-12 deficiency and in kidney dysfunction. Population reference values for serum MMA concentrations in post-folic acid fortification period are lacking. Aims of this study were to report the population reference values (...) for serum MMA and to evaluate the relation between serum MMA and sex, age, race-ethnicity, kidney dysfunction and vitamin B-12. We used data from three National Health and Nutrition Examination Surveys, 1999-2000, 2001-2002 and 2003-2004 conducted after folic acid fortification commenced (n = 18,569). Geometric mean MMA was ≈22.3% higher in non-Hispanic white compared to non-Hispanic black (141.2 vs. 115.5 nmol/L) and was ≈62.7% higher in >70 years old persons compared to 21-30 years old persons (196.9

2018 Nutrients

27. Foods and Supplements Associated with Vitamin B12 Biomarkers among Vegetarian and Non-Vegetarian Participants of the Adventist Health Study-2 (AHS-2) Calibration Study Full Text available with Trip Pro

Foods and Supplements Associated with Vitamin B12 Biomarkers among Vegetarian and Non-Vegetarian Participants of the Adventist Health Study-2 (AHS-2) Calibration Study To investigate the association between plasma concentration of vitamin B12 and B12 intake from supplements, fortified foods, and animal source foods among vegetarians and non-vegetarians, we conducted a cross-sectional analysis among 728 participants of the Adventist Health Study 2 (AHS-2) calibration study. The median age (...) of participants was 58 years, 65.4% were female, and 50.3% were White. We used six 24 h dietary recalls to measure B12 intake, serum vitamin B12, and holotranscobalamin (holoTC) concentration. B12 supplements had a significantly positive association with plasma B12 among all subjects (p trend < 0.001), especially among vegans and lacto-ovo vegetarians (p trend < 0.001). Among non-users of B12 supplements, B12 intake from milk substitutes was significantly positively associated with holoTC (p trend < 0.004

2018 Nutrients

28. Vitamin B12 supplementation in women of reproductive age

Vitamin B12 supplementation in women of reproductive age Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith

2020 PROSPERO

29. The effects of vitamin B12 supplementation during pregnancy on fetal growth, birth weight and length of gestation: A systematic review and individual participant data meta-analysis of trials

The effects of vitamin B12 supplementation during pregnancy on fetal growth, birth weight and length of gestation: A systematic review and individual participant data meta-analysis of trials Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility

2020 PROSPERO

30. Vitamin A and beta (β)-carotene supplementation for cystic fibrosis. Full Text available with Trip Pro

Vitamin A and beta (β)-carotene supplementation for cystic fibrosis. People with cystic fibrosis (CF) and pancreatic insufficiency are at risk of a deficiency in fat-soluble vitamins, including vitamin A. Vitamin A deficiency predominantly causes eye and skin problems, while excessive levels of vitamin A can harm the respiratory and skeletal systems in children and interfere with the metabolism of other fat-soluble vitamins. Most CF centres administer vitamin A as supplements to reduce (...) the frequency of vitamin A deficiency in people with CF and to improve clinical outcomes such as growth, although the recommended dose varies between different guidelines. Thus, a systematic review on vitamin A and vitamin A-like supplementation (carotenes or other retinoids) in people with CF would help guide clinical practice. This is an update of an earlier Cochrane Review.To determine if supplementation with vitamin A, carotenes or other retinoid supplements in children and adults with CF reduces

2018 Cochrane

31. Dietary Intake of Vitamin B12 is Better for Restoring a Low B12 Status Than a Daily High-Dose Vitamin Pill: An Experimental Study in Rats Full Text available with Trip Pro

Dietary Intake of Vitamin B12 is Better for Restoring a Low B12 Status Than a Daily High-Dose Vitamin Pill: An Experimental Study in Rats Vitamin B12 (B12) is present in foods of animal origin, and vegans are encouraged to take supplements with synthetic B12 in order to ensure a sufficient uptake. Recent rat studies suggest that natural (hydroxo-B12, HO-B12) and synthetic (cyano-B12, CN-B12) B12 behave differently in the body. Here, we test if a daily vitamin pill matches dietary B12 in ability (...) to restore a low B12 status in rats. B12-depleted male Wistar rats (n = 60) were divided into five groups (n = 12 in each) and subjected to two weeks intervention with various schemes of B12 supplementation. Two "dietary" groups received a low-B12 chow that was fortified with either HO-B12 or CN-B12 providing a continuous supply. Two "pill" groups received a single daily dose of CN-B12, where the vitamin content either matched or exceeded by factor four the provisions for the "dietary" groups. A control

2018 Nutrients

32. Calcium and Vitamin D Supplementation for Adults: Safety and Guidelines

Calcium and Vitamin D Supplementation for Adults: Safety and Guidelines Calcium and Vitamin D Supplementation for Adults: Safety and Guidelines | CADTH.ca Find the information you need Calcium and Vitamin D Supplementation for Adults: Safety and Guidelines Calcium and Vitamin D Supplementation for Adults: Safety and Guidelines Last updated: June 7, 2018 Project Number: RB1229-000 Product Line: Research Type: Drug Report Type: Summary of Abstracts Result type: Report Question What (...) is the clinical evidence for the safety of calcium and vitamin D supplementation in adults? What are the evidence-based guidelines regarding the use of calcium and vitamin D supplements in the general adult population? Key Message Thirteen systematic reviews (seven with meta-analyses), 30 randomized controlled trials, and seven evidence based guidelines were identified regarding calcium and vitamin D supplementation in adults. Files Rapid Response Summary of Abstracts Published : June 7, 2018 Related Content

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

33. Vitamin D Supplementation for the General Population: Clinical Evidence and Guidelines

Vitamin D Supplementation for the General Population: Clinical Evidence and Guidelines Vitamin D Supplementation for the General Population: Clinical Evidence and Guidelines | CADTH.ca Find the information you need Vitamin D Supplementation for the General Population: Clinical Evidence and Guidelines Vitamin D Supplementation for the General Population: Clinical Evidence and Guidelines Last updated: November 7, 2018 Project Number: RB1274-000 Product Line: Research Type: Drug Report Type (...) : Summary of Abstracts Result type: Report Question What is the clinical evidence regarding routine vitamin D supplementation in the general population? What are the evidence-based guidelines regarding vitamin D supplementation in the general population? Key Message Ten systematic reviews with meta-analyses and one evidence-based guideline were identified regarding vitamin d supplementation for the general population. No evidence-based guidelines were identified. Files Rapid Response Summary

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

36. Comparative Bioavailability of Synthetic B12 and Dietary Vitamin B12 Present in Cow and Buffalo Milk: A Prospective Study in Lactovegetarian Indians. Full Text available with Trip Pro

Comparative Bioavailability of Synthetic B12 and Dietary Vitamin B12 Present in Cow and Buffalo Milk: A Prospective Study in Lactovegetarian Indians. We assessed improvements in the vitamin B12 status of Indian lactovegetarians receiving four weeks supplementation with natural B12 in milk versus cyano-B12 in capsules. Three groups (n = 22, 23, 22) received daily oral doses of cyano-B12 (2 × 0.76 µg) or milk (2 × 200 mL) from a cow or buffalo (amounting to B12 ≈ 2 × 0.76 µg). Their blood (...) was examined at baseline and each following week. The baselines (median (min/max)) indicated a low B12 status: plasma B12 (116(51/314)) pmol/L, holotranscobalamin (holoTC) (30(7/119)) pmol/L, total homocysteine (Hcy) (24(10/118)) µmol/L, methylmalonic acid (MMA) (0.58(0.15/2.2)) µmol/L and combined B12 index (cB12) (-1.32 - (-3.12/+0.29)). Shifts from the baselines (B12, holoTC, cB12) and ratios to the baselines (Hcy, MMA) were analyzed over time. The cyano-B12 treatment gave more total B12 in plasma

2019 Nutrients Controlled trial quality: uncertain

37. Effect of Vitamin D3 Supplementation on Severe Asthma Exacerbations in Children With Asthma and Low Vitamin D Levels: The VDKA Randomized Clinical Trial. (Abstract)

Effect of Vitamin D3 Supplementation on Severe Asthma Exacerbations in Children With Asthma and Low Vitamin D Levels: The VDKA Randomized Clinical Trial. Severe asthma exacerbations cause significant morbidity and costs. Whether vitamin D3 supplementation reduces severe childhood asthma exacerbations is unclear.To determine whether vitamin D3 supplementation improves the time to a severe exacerbation in children with asthma and low vitamin D levels.The Vitamin D to Prevent Severe Asthma (...) Exacerbations (VDKA) Study was a randomized, double-blind, placebo-controlled clinical trial of vitamin D3 supplementation to improve the time to severe exacerbations in high-risk children with asthma aged 6 to 16 years taking low-dose inhaled corticosteroids and with serum 25-hydroxyvitamin D levels less than 30 ng/mL. Participants were recruited from 7 US centers. Enrollment started in February 2016, with a goal of 400 participants; the trial was terminated early (March 2019) due to futility, and follow

2020 JAMA

38. Supplementation with vitamin D plus calcium reduces fracture risk; vitamin D alone does not. (Abstract)

Supplementation with vitamin D plus calcium reduces fracture risk; vitamin D alone does not. Yao P, Bennett D, Mafham M, et al. Vitamin D and calcium for the prevention of fracture: a systematic review and meta-analysis. JAMA Netw Open. 2019;2:e1917789. 31860103.

2020 Annals of Internal Medicine

39. Vitamin K supplementation for cystic fibrosis. Full Text available with Trip Pro

Vitamin K supplementation for cystic fibrosis. Cystic fibrosis is a genetic disorder which can lead to multiorgan dysfunction. Malabsorption of fat and fat-soluble vitamins (A, D, E, K) may occur and can cause subclinical deficiencies of some of these vitamins. Vitamin K is known to play an important role in both blood coagulation and bone formation. Supplementation with vitamin K appears to be one way of addressing the deficiency, but there is very limited agreement on the appropriate dose (...) and frequency of use of these supplements. This is an updated version of the review.To assess the effects of vitamin K supplementation in people with cystic fibrosis and to determine the optimal dose and route of administration of vitamin K for both routine and therapeutic use.We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group's Trials Register comprising references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books

2017 Cochrane

40. Vitamin D supplementation for sickle cell disease. Full Text available with Trip Pro

Vitamin D supplementation for sickle cell disease. Sickle cell disease is a genetic chronic haemolytic and pro-inflammatory disorder. The clinical manifestations of sickle cell disease result from the presence of mutations on the beta globin genes that generate an abnormal haemoglobin product (called haemoglobin S) within the red blood cell. Sickle cell disease can lead to many complications such as acute chest syndrome, stroke, acute and chronic bone complications (including painful vaso (...) and the safety of vitamin D supplementation in sickle cell disease.To investigate the hypothesis that vitamin D supplementation increases serum 25-hydroxyvitamin D level in children and adults with sickle cell disease.To determine the effects of vitamin D supplementation on general health such as growth status and health-related quality of life; on musculoskeletal health including bone mineral density, pain crises, bone fracture and muscle health; on respiratory health which includes lung function tests

2017 Cochrane

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