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Vitamin B12 Supplementation

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241. Effects of supplemental vitamin D and calcium on markers of proliferation, differentiation, and apoptosis in the normal colorectal mucosa of colorectal adenoma patients. Full Text available with Trip Pro

Effects of supplemental vitamin D and calcium on markers of proliferation, differentiation, and apoptosis in the normal colorectal mucosa of colorectal adenoma patients. To clarify the roles of vitamin D and calcium as potential chemopreventive agents against colorectal cancer in humans, and to develop "treatable", pre-neoplastic, phenotypic biomarkers of risk for colorectal neoplasms, we estimated the effects of supplemental vitamin D3 (1,000 IU/day [25 μg/day]) and calcium (1,200 mg/day (...) analysis. In the vitamin D plus calcium group relative to control, in the crypt differentiation zone (upper 40% of crypts), mib-1 expression decreased 24% (P = 0.28); p21 expression alone and relative to mib-1 expression increased 29% (P = 0.06) and 73% (P = 0.06), respectively; and bax expression relative to mib-1 expression increased 58% (P = 0.21). The estimated vitamin D alone treatment effects were similar but of lesser magnitudes, and those for calcium alone were mixed. All estimated treatment

2018 PLoS ONE Controlled trial quality: predicted high

242. Trends in vitamin D supplement use in a general female and breast cancer population in Ireland: A repeated cross-sectional study. Full Text available with Trip Pro

Trends in vitamin D supplement use in a general female and breast cancer population in Ireland: A repeated cross-sectional study. Vitamin D has been linked with improved survival after breast cancer diagnosis but little is known about prescribing rates. This study investigates trends in vitamin D supplement use in both a general female and breast cancer population.Women with a breast cancer diagnosis were identified from the National Cancer Registry of Ireland (n = 19870). Women who had any (...) vitamin D claim between 2005 and 2011 were identified from pharmacy claims data (n = 8556). Prevalence rates were calculated as a proportion of all eligible women and by age (< 55 years, ≥ 55 years). Poisson regression was used to compare rates of vitamin D prescribing across years (risk ratio (RR), 95% CI).There was a statistically significant increase in women with a claim for vitamin D between 2005-2011, with the largest increase among breast cancer patients aged ≥ 55 years (RR = 2.26; 95% CI, 2.11

2018 PLoS ONE

244. Do all infants need vitamin D supplementation? Full Text available with Trip Pro

Do all infants need vitamin D supplementation? A high prevalence of vitamin D deficiency (VDD) in children has been observed worldwide, but there are few studies on the nutritional status of vitamin D (VD) in healthy infants. The main cause of deficiency in healthy children is breastfeeding without supplementation and lack or insufficiency of sun exposure. The aims of this study were to determine serum concentrations of 25(OH)D and verify its association with parathyroid hormone (PTH (...) ) concentrations and use of VD supplementation in healthy infants aged ≥ 6 to ≤ 24 months attended at two Primary Health Care Units in Ribeirão Preto city, São Paulo, Brazil. A cross-sectional, observational and analytical study was performed in which serum concentrations of 25(OH)D, PTH, alkaline phosphatase (AP), calcium (Ca), phosphorus (P) and albumin were determined in 155 healthy infants. Information on sun exposure, sociodemographic aspects of mothers and clinical and nutritional characteristics

2018 PLoS ONE

245. Acute Homeostatic Changes Following Vitamin D2 Supplementation Full Text available with Trip Pro

Acute Homeostatic Changes Following Vitamin D2 Supplementation Changes in vitamin D binding protein (DBP) concentrations and catabolism of 25-hydroxyvitamin D to 24,25-dihydroxyvitamin D (24,25D) after vitamin D2 supplementation may alter concentrations and bioavailability of circulating 25-hydroxyvitamin D (25D).Examine acute changes in vitamin D metabolism and bioavailability after vitamin D2 supplementation.Study design was secondary analysis of a single-arm interventional study. Thirty (...) consenting volunteers were treated with five 50,000 IU oral doses of ergocalciferol over 2 weeks. Main outcome measures included concentrations of DBP, vitamin D metabolites, and bioavailable 25-hydroxyvitamin D (25D) in pre- and posttreatment serum samples.After supplementation, 25D2 (mean ± standard deviation) increased from 1.4 ± 0.9 ng/mL to 45.3 ± 16.5 ng/mL (P < 0.0001), and 25D3 levels decreased from 26.8 ± 9.9 ng/mL to 19.7 ± 8.2 ng/mL (P < 0.0001). Total 25D (25D2 plus 25D3) increased from 28.2

2017 Journal of the Endocrine Society Controlled trial quality: uncertain

246. Gene expression in breast and adipose tissue after 12 months of weight loss and vitamin D supplementation in postmenopausal women Full Text available with Trip Pro

Gene expression in breast and adipose tissue after 12 months of weight loss and vitamin D supplementation in postmenopausal women Adipose tissue is involved in the etiology of postmenopausal breast cancer, possibly through increased sex steroid hormone production, inflammation, and altered adipokines. Vitamin D may affect these pathways but its effect on gene expression in different tissues has not been examined. Within a double-blind, 12-month placebo-controlled randomized trial, we compared (...) 2000 IU/day oral vitamin D3 supplementation (N = 39) vs. placebo (N = 40) on the expression of 5 genes in breast and adipose tissue in overweight/obese postmenopausal women (50-75 years). All participants had serum 25-hydroxyvitamin D (25(OH)D) levels ≥ 10-<32 ng/mL ("insufficient") and concurrently completed a behavioral weight loss program. Random periareolar fine needle aspiration (RPFNA) and abdominal subcutaneous adipose tissue biopsies were performed at baseline and 12 months. Changes

2017 NPJ breast cancer Controlled trial quality: predicted high

247. Effects of symbiotic and vitamin E supplementation on blood pressure, nitric oxide and inflammatory factors in non-alcoholic fatty liver disease Full Text available with Trip Pro

Effects of symbiotic and vitamin E supplementation on blood pressure, nitric oxide and inflammatory factors in non-alcoholic fatty liver disease Non-alcoholic fatty liver disease (NAFLD) has been suggested to be well correlated with altered blood pressure. This study was conducted to determine the effects of symbiotic and vitamin E supplementation on blood pressure and inflammatory indices of patients with NAFLD. This randomized, double-blind, placebo-controlled trial was performed among 60 (...) NAFLD patients aged 25 to 64 years old. Participants were randomly divided into four groups to receive a 400 IU alpha-tocopherol and 2 × 108 CFU/g symbiotic supplement for 8 weeks. The anthropometric parameters, systolic blood pressure (SBP) and diastolic blood pressure (DBP), serum malondialdehyde (MDA), nitric oxide (NO) and tumor necrosis factor α (TNFα) were assessed at baseline and after 8 weeks of intervention. After 8 weeks of intervention, combined symbiotic and alpha-tocopherol, symbiotic

2017 EXCLI journal Controlled trial quality: predicted high

248. MTHFR 677C → T genotype modulates the effect of a 5-year supplementation with B-vitamins on homocysteine concentration: The SU.FOL.OM3 randomized controlled trial. Full Text available with Trip Pro

of vitamin B12), 2) n-3 fatty acids alone (600 mg of EPA and DHA in a 2:1 ratio), 3) B-vitamins and n-3 fatty acids, and 4) placebo. Participants were followed up for 4.7 years. At baseline and annually thereafter, biological parameters were assessed. Multivariate and linear mixed models were fit to study the interaction between B-vitamins and MTHFR genotype.Among supplemented participants, concentrations of all three B-vitamins increased during the first year (all p<0.0001) across MTHFR genotype (...) MTHFR 677C → T genotype modulates the effect of a 5-year supplementation with B-vitamins on homocysteine concentration: The SU.FOL.OM3 randomized controlled trial. To study how MTHFR 677C→T genotype modulates the effect of supplementation with B-vitamins on total homocysteine (tHcy) and B-vitamin concentrations.2381 patients with a personal history of cardiovascular disease were randomly assigned to one of four groups: 1) B-vitamins alone (560 μg of 5-methyl-THF, 3 mg of vitamin B6 and 20 μg

2018 PLoS ONE Controlled trial quality: uncertain

249. A randomized, controlled pilot study of the effects of vitamin D supplementation on balance in Parkinson's disease: Does age matter? Full Text available with Trip Pro

A randomized, controlled pilot study of the effects of vitamin D supplementation on balance in Parkinson's disease: Does age matter? To explore if short term, high dose vitamin D supplementation is safe and improves balance in persons with Parkinson's disease (PD).A pilot randomized, double-blind intervention trial to measure the effects of 16 weeks of high dose vitamin D (10,000 IU/day) on balance as well as other motor and non-motor features of PD. We measured balance, gait, strength, falls (...) , cognition, mood, PD severity, and quality of life before and after 16 weeks of high dose vitamin D supplementation or placebo. All participants also received 1000 mg calcium once daily.Fifty-one randomized participants completed sixteen weeks of high dose vitamin D supplementation or placebo. The intervention resulted in a rise in serum concentrations of vitamin D (25-OH) (30.2 ng/ml to 61.1 ng/ml) and was well tolerated with no serious adverse events. Serum vitamin D (25-OH) levels rose steadily

2018 PLoS ONE Controlled trial quality: predicted high

250. Preventing vitamin B12 deficiency in South Asian women of childbearing age: a randomised controlled trial comparing an oral vitamin B12 supplement with B12 dietary advice. Full Text available with Trip Pro

Preventing vitamin B12 deficiency in South Asian women of childbearing age: a randomised controlled trial comparing an oral vitamin B12 supplement with B12 dietary advice. To examine the effectiveness, acceptability and sustainability of interventions to reduce vitamin B12 (B12) deficiency in South Asian women before conception.A 6-month randomised controlled trial conducted in Auckland, New Zealand. Participants (62 South Asian women, 18-50 years old) were stratified by dietary practices (...) , then randomised to three treatment groups: B12 Supplement (oral cyanocobalamin 6 μg/day) (n=21), Placebo (n=21), or B12 Dietary Advice (n=20). Primary outcome measures were changes in B12 biomarkers (serum B12 and holotranscobalamin (holoTC)) at 6 months. Dietary B12 intake was estimated from a B12 food-specific frequency questionnaire (B12FFQ). Intention-to-treat analysis was applied using 'last observation carried forward' method. Changes in B12 biomarkers by treatment were compared using analysis

2014 European journal of clinical nutrition Controlled trial quality: predicted high

251. Vitamin D and rickets: supplementation for some children

Vitamin D and rickets: supplementation for some children Prescrire IN ENGLISH - Spotlight ''Vitamin D and rickets: supplementation for some children'', 1 March 2014 {1} {1} {1} | | > > > Vitamin D and rickets: supplementation for some children Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight Vitamin D and rickets: supplementation for some children (...) supplementation in the form of cod liver oil, medications, and fortified foods. Since the 1980s , rickets in these countries has mainly affected breastfed children under the age of 5 years with dark skin. A few cases have also been reported in dark-skinned adolescents. The main source of vitamin D is cutaneous synthesis stimulated by solar ultraviolet B radiation. Between 2 and 3 hours of sunlight exposure per week appears sufficient to meet vitamin D requirements in fair-skinned infants. Dietary vitamin D

2014 Prescrire

252. What is the best age to start vitamin D supplementation to prevent rickets in breastfed newborns?

What is the best age to start vitamin D supplementation to prevent rickets in breastfed newborns? What is the best age to start vitamin D supplementation to prevent rickets in breastfed newborns? Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics What is the best age to start vitamin D supplementation to prevent rickets (...) in breastfed newborns? View/ Open Date 2013-12 Format Metadata Abstract Evidence-based answer: It’s unclear what age is best to start vitamin D supplementation because no comparison studies exist. That said, breastfed infants who take vitamin D beginning at 3 to 5 days of life don’t develop rickets (strength of recommendation SOR]: B, randomized trial). Starting infants on vitamin D supplementation at one to 36 months of age reduces the risk of rickets (SOR: B, a controlled and a randomized controlled

2014 Clinical Inquiries

253. Vitamin K supplementation for cystic fibrosis. Full Text available with Trip Pro

Vitamin K supplementation for cystic fibrosis. Cystic fibrosis is a genetic disorder which can lead to multiorgan dysfunction. Malabsorption of fat and fat-soluble vitamins (A, D, E, K) may occur and can cause subclinical deficiencies of some of these vitamins. Vitamin K is known to play an important role in both blood coagulation and bone formation. Supplementation with vitamin K appears to be one way of addressing the deficiency, but there is very limited agreement on the appropriate dose (...) and frequency of use of these supplements.To assess the effects of vitamin K supplementation in people with cystic fibrosis and to determine the optimal dose and route of administration of vitamin K for both routine and therapeutic use.We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group's Trials Register comprising references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings.Most recent search: 11

2013 Cochrane

254. Vitamin Supplementation for Hospitalized Adults

Vitamin Supplementation for Hospitalized Adults TITLE: Vitamin Supplementation for Hospitalized Adults: Clinical Evidence and Guidelines DATE: 28 March 2014 RESEARCH QUESTIONS 1. What is the clinical evidence regarding the optimal use of vitamin B12, zinc, or magnesium supplementation in hospitalized adults? 2. What are the evidence-based guidelines regarding the optimal use and dosing of vitamin B12, zinc, or magnesium supplementation in hospitalized adults? KEY MESSAGE No relevant health (...) technology assessments, systematic reviews, meta-analyses, randomized controlled trials, non-randomized studies, or evidence-based guidelines were identified regarding the optimal use of vitamin B12, zinc, or magnesium supplementation in hospitalized adults. METHODS A limited literature search was conducted on key resources including PubMed, The Cochrane Library (2014, Issue 3), University of York Centre for Reviews and Dissemination (CRD) databases, Canadian and major international health technology

2014 Canadian Agency for Drugs and Technologies in Health - Rapid Review

255. Vitamin A and fish oils for preventing the progression of retinitis pigmentosa. (Abstract)

. The rest of the trials reported no adverse events, and no study reported any evidence of benefit of vitamin supplementation on the progression of visual acuity loss.Based on the results of four studies, it is uncertain if there is a benefit of treatment with vitamin A or DHA, or both for people with RP. Future trials should also take into account the changes observed in ERG amplitudes and other outcome measures from trials included in this review.Copyright © 2020 The Cochrane Collaboration. Published (...) Vitamin A and fish oils for preventing the progression of retinitis pigmentosa. Retinitis pigmentosa (RP) comprises a group of hereditary eye diseases characterized by progressive degeneration of retinal photoreceptors. It results in severe visual loss that may lead to blindness. Symptoms may become manifest during childhood or adulthood which include poor night vision (nyctalopia) and constriction of peripheral vision (visual field loss). Visual field loss is progressive and affects central

2020 Cochrane

256. In patients on Metformin with vitamin b12 deficiency, is it worth trying oral b12 supplements rather than initiating treatment by injection immediately?

In patients on Metformin with vitamin b12 deficiency, is it worth trying oral b12 supplements rather than initiating treatment by injection immediately? In patients on Metformin with vitamin b12 deficiency, is it worth trying oral b12 supplements rather than initiating treatment by injection immediately? - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT (...) supplements rather than initiating treatment by injection immediately? ATTRACT found no guidance on correction of vitamin B12 deficiency arising directly from metformin use though a recent RCT (1) confirmed decreased mean B12 levels in a cohort of 390 patients with medium-term follow-up of 4.3 years. A Cochrane review on oral therapy versus intramuscular therapy for vitamin B12 deficiency (2) concluded. “The evidence derived from these limited studies suggests that 2000 mcg doses of oral vitamin B12 daily

2012 TRIP Answers

257. Can vitamin B12 deficiency manifest with acute posterolateral or posterior cord syndrome? Full Text available with Trip Pro

parenteral vitamin B12 supplementation. Vitamin B12 deficiency can present with acute neurological manifestations. (...) Can vitamin B12 deficiency manifest with acute posterolateral or posterior cord syndrome? Vitamin B12 deficiency can cause varied neurological manifestations which are subacute to chronic in onset. Subacute combined degeneration of spinal cord is one such characteristic neurological manifestation of vitamin B12 deficiency. We report a case series of five patients who presented with acute onset (<15 days) neurological manifestations due to vitamin B12 deficiency. Detailed history and clinical

2016 Spinal cord series and cases

258. Vitamin B12 for Aromatase Inhibitors Musculoskeletal Symptoms

. Vitamin B12, whether as injection or oral forms, has been used as a naturopathic product to provide relief for joint pain caused by arthritis. This effect has not been studied in the setting of Aromatase Inhibitor-Associated Musculoskeletal Symptoms (AIMSS). Condition or disease Intervention/treatment Phase Relief of Joint Pain Dietary Supplement: Vitamin B12 Not Applicable Detailed Description: Primary Objectives: a. To assess whether daily oral Vitamin B12 decreases average joint pain in women (...) Stage Breast Cancer Actual Study Start Date : October 19, 2015 Actual Primary Completion Date : October 27, 2016 Actual Study Completion Date : October 27, 2016 Resource links provided by the National Library of Medicine related topics: related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Arm I Oral Vitamin B12 Dietary Supplement: Vitamin B12 Vitamin B12 2500 micrograms sublingually per day over the course of 90 days (+/- 10 days) Outcome Measures Go

2017 Clinical Trials

259. The Impact of Vitamin B12 Deficiency on Infant Gut Microbiota

withdrawal. For the reporting, serum vitamin B12 <203 pg/mL is considered as vitamin B12 deficiency, and ≥203 pg/mL as vitamin B12 sufficient. Infants with vitamin B12 deficiency are treated with intramuscular vitamin b12 (hydroxycobalamin), 250-500 mcg twice weekly for a week, and then 500 mcg weekly for another 3 weeks. One month after the supplementation in the recommended dose, stools are recollected in a subgroup of subjects (n=11) with vitamin B12 deficiency. Samples are kept at 4 C and in less (...) The Impact of Vitamin B12 Deficiency on Infant Gut Microbiota The Impact of Vitamin B12 Deficiency on Infant Gut Microbiota - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Impact of Vitamin B12

2017 Clinical Trials

260. High folate and low vitamin B12 status during pregnancy is associated with gestational diabetes mellitus. Full Text available with Trip Pro

adjusting for other B-vitamins.Higher maternal folate coupled with vitamin B12 insufficiency was associated with higher GDM risk. This finding has potential implications for antenatal supplement recommendations but will require confirmation in future studies.Copyright © 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. (...) High folate and low vitamin B12 status during pregnancy is associated with gestational diabetes mellitus. B-vitamins and homocysteine may contribute to the development of gestational diabetes mellitus (GDM), but existing studies are inconsistent. We examined the cross-sectional associations of plasma folate, vitamins B6, B12, and homocysteine concentrations with GDM and glycemia in a sample of multi-ethnic Asian pregnant women.Plasma concentrations of folate, vitamins B6, B12, homocysteine

2017 Clinical nutrition (Edinburgh, Scotland)

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