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Vitamin B12 Supplementation

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22401. A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa. (Abstract)

A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa. 8240094 1993 12 07 2015 04 17 0003-9950 111 11 1993 Nov Archives of ophthalmology (Chicago, Ill. : 1960) Arch. Ophthalmol. A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa. 1461-2; author reply 1462-5 Clowes D D DD eng Clinical Trial Comment Comparative Study Letter Randomized Controlled Trial United States Arch Ophthalmol 7706534 0003-9950 11103-57-4 Vitamin A 1406-18-4 (...) Vitamin E AIM IM Arch Ophthalmol. 1993 Jun;111(6):761-72 8512476 Adult Follow-Up Studies Humans Male Research Design Retinitis Pigmentosa drug therapy Vitamin A adverse effects Vitamin E adverse effects 1993 11 1 1993 11 1 0 1 1993 11 1 0 0 ppublish 8240094

1993 Archives of ophthalmology (Chicago, Ill. : 1960) Controlled trial quality: uncertain

22402. A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa. (Abstract)

A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa. 8240095 1993 12 07 2015 04 17 0003-9950 111 11 1993 Nov Archives of ophthalmology (Chicago, Ill. : 1960) Arch. Ophthalmol. A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa. 1463; author reply 1463-6 Fielder A R AR eng Clinical Trial Comment Comparative Study Letter Randomized Controlled Trial United States Arch Ophthalmol 7706534 0003-9950 11103-57-4 Vitamin A 1406-18-4 (...) Vitamin E AIM IM Arch Ophthalmol. 1993 Jun;111(6):761-72 8512476 Adult Humans Research Design Retinitis Pigmentosa drug therapy Vitamin A therapeutic use Vitamin E therapeutic use 1993 11 1 1993 11 1 0 1 1993 11 1 0 0 ppublish 8240095

1993 Archives of ophthalmology (Chicago, Ill. : 1960) Controlled trial quality: uncertain

22403. A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa. (Abstract)

A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa. 8292202 1993 12 07 2015 04 17 0003-9950 111 11 1993 Nov Archives of ophthalmology (Chicago, Ill. : 1960) Arch. Ophthalmol. A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa. 1462-3 Gamel J W JW Barr C C CC eng Clinical Trial Comment Comparative Study Letter United States Arch Ophthalmol 7706534 0003-9950 11103-57-4 Vitamin A 1406-18-4 Vitamin E AIM IM Arch Ophthalmol (...) . 1993 Jun;111(6):761-72 8512476 Humans Research Design Retinitis Pigmentosa drug therapy Treatment Outcome Vitamin A therapeutic use Vitamin E therapeutic use 1993 11 1 1993 11 1 0 1 1993 11 1 0 0 ppublish 8292202

1993 Archives of ophthalmology (Chicago, Ill. : 1960) Controlled trial quality: uncertain

22404. Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa

Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00000114 Recruitment Status : Completed First Posted : September 24, 1999 Last Update Posted : September 17, 2009 Sponsor: National Eye Institute (NEI

1999 Clinical Trials

22405. Effect of vitamin C supplementation on concentrations of vitamins C and E in fasting plasma. (Abstract)

Effect of vitamin C supplementation on concentrations of vitamins C and E in fasting plasma. Vitamin C may 'spare' vitamin E, but this has not to date been confirmed as occurring in vivo. The aim of this study was to test the effect of dietary supplementation with vitamin C on total and lipid standardised vitamin E concentrations in fasting plasma, the hypothesis being that increased vitamin C intake leads to improved vitamin E levels. In this single-blinded study, 12 apparently healthy adults (...) (seven men, five women) took 1 g/day vitamin C for 28 days, with a 28-day placebo-controlled run-in cycle and a 28-day placebo-controlled washout cycle. Concentrations of ascorbic acid, total vitamin E (as total tocopherols) and lipid standardised vitamin E (Vit ELS, expressed as mol vitamin E/mmol total cholesterol plus triglycerides) were measured in fasting plasma after each cycle. Results showed that vitamin C supplementation led to significant increases in ascorbic acid, total vitamin E and Vit

1999 Asia Pacific journal of clinical nutrition Controlled trial quality: uncertain

22406. The effect of vitamin D supplementation on vitamin D status and parathyroid function in elderly subjects. (Abstract)

The effect of vitamin D supplementation on vitamin D status and parathyroid function in elderly subjects. Vitamin D deficiency is common in the elderly and may lead to secondary hyperparathyroidism, cortical bone loss, and hip fractures. The effect of vitamin D supplementation for 1 yr was studied in 72 people living in a nursing home and 70 people living in an aged people's home. The subjects were randomized into 3 groups: control, and 400 or 800 IU vitamin D3/day. The initial vitamin D status (...) of each subject was classified as deficient or borderline [serum 25-hydroxyvitamin D (25OHD) less than 30 nmol/L] in 79% and adequate (serum 25OHD greater than or equal to 30 nmol/L) in 21%. Serum 25OHD concentrations increased about 3-fold in both groups receiving vitamin D supplementation. Serum 1,25-dihydroxyvitamin D [1,25-(OH)2D] concentrations increased slightly but significantly, and the increase was inversely related to the initial serum 25OHD concentration. Serum intact PTH-(1-84

1988 The Journal of clinical endocrinology and metabolism Controlled trial quality: uncertain

22407. Vitamin status of inpatients with chronic cephalgia and dysfunction pain syndrome and effects of a vitamin supplementation. (Abstract)

Vitamin status of inpatients with chronic cephalgia and dysfunction pain syndrome and effects of a vitamin supplementation. 66 female inpatients with dysfunction pain syndrome, chronic cephalgia and facial pain participated in a randomized, placebo-controlled double-blind study, half the patients receiving a multivitamin preparation for 12 days and the other half a placebo. The biochemically determined vitamin status at the start of the study revealed gaps in the coverage of the vitamin supply (...) , particularly with regard to the vitamins thiamin, riboflavin and folic acid. 65% of the patients showed a subclinical vitamin deficiency of two or more vitamins. With regard to the development of pain during the study no statistically significant differences could be determined, however, between the active-treatment and placebo groups. Nevertheless, a clear reduction in pain was more frequently observed in the active-treatment group, and a deterioration of pain more frequently in the placebo group

1988 International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition Controlled trial quality: uncertain

22408. Bone mineral content, serum vitamin D metabolite concentrations, and ultraviolet B light exposure in infants fed human milk with and without vitamin D2 supplements. (Abstract)

Bone mineral content, serum vitamin D metabolite concentrations, and ultraviolet B light exposure in infants fed human milk with and without vitamin D2 supplements. To monitor ultraviolet B light exposure in human milk-fed infants both with and without supplemental vitamin D2, and to measure longitudinally the bone mineral content, growth, and serum concentrations of calcium, phosphorus, 25-hydroxyvitamin D3, 25-hydroxyvitamin D2, 1,25-dihydroxyvitamin D, and parathyroid hormone.Longitudinal (...) , randomized, double-blind, placebo-controlled study of 6 months' duration.Patients from private pediatric practice, Madison, Wisconsin.Sequential sampling of 46 human milk-fed white infants; 24 received 400 IU/day of vitamin D2, and 22 received placebo. An additional 12 patients were followed who received standard infant formula. Eighty-three percent of patients completed a full 6 months of the study.Ultraviolet B light exposure and measurements of growth did not differ between groups. At 6 months

1989 The Journal of pediatrics Controlled trial quality: predicted high

22409. Oral supplementation of vitamin K for pregnant women and effects on levels of plasma vitamin K and PIVKA-II in the neonate. (Abstract)

Oral supplementation of vitamin K for pregnant women and effects on levels of plasma vitamin K and PIVKA-II in the neonate. Levels of plasma vitamin K1 (VK1) and vitamin K2 (VK2) and protein-induced vitamin K absence-II (PIVKA-II) were measured in Japanese mothers and their newborn (N = 33). Twenty milligrams of VK1 (N = 11) or VK2 (N = 12) were given orally to randomly selected mothers 7 to 10 days prior to delivery. Means of plasma VK1 and VK2 concentrations were significantly higher in VK1

1990 Journal of pediatric gastroenterology and nutrition Controlled trial quality: uncertain

22410. Effect of vitamin A supplementation of intravenous lipids on early vitamin A intake and status of premature infants. (Abstract)

Effect of vitamin A supplementation of intravenous lipids on early vitamin A intake and status of premature infants. Preterm infants were randomly assigned to receive routine vitamin A supplementation (Regular A) or additional vitamin A in intravenous lipids (High A). Because infants with bronchopulmonary dysplasia (BPD) have poorer vitamin A status than infants who do not develop BPD, High A and Regular A infants were divided by BPD (no or yes) before determining the effects of treatment (...) on intake and plasma concentration of retinol in the first month. Compared with infants without BPD, those with BPD received less retinol (RE.kg-1.d-1) if assigned to Regular A and more if assigned to High A (BPD by vitamin A interaction, P < 0.002). High A-BPD infants compared with Regular A-BPD infants had significantly higher plasma retinol concentrations in the first month. Retinyl palmitate appears to be an effective adjunct to routine vitamin A administration. Infants most likely to benefit from

1994 The American journal of clinical nutrition Controlled trial quality: uncertain

22411. Acute respiratory infections prevent improvement of vitamin A status in young infants supplemented with vitamin A. Full Text available with Trip Pro

Acute respiratory infections prevent improvement of vitamin A status in young infants supplemented with vitamin A. At immunization contact, 165 infants 2.5 mo old were randomly assigned to receive either 15 mg vitamin A (retinyl palmitate) or placebo. Three doses were given at monthly intervals with each diphtheria, pertussis, tetanus and oral polio (DPT/OPV) immunization dose. The diarrhea and acute respiratory infection (ARI) morbidity was similar in the vitamin A and placebo groups. However (...) A-supplemented group the serum retinol concentration was significantly better than that in the placebo group (P= 0.02). However, 61% of the infants remained deficient despite vitamin A supplementation. Among vitamin A-supplemented infants only, diarrhea and ARI morbidity during the 3-mo period were compared in children with normal versus children with abnormal RDR at the end of the supplementation period. The ARI episodes were more frequent in the supplemented infants who remained vitamin A deficient

1996 The Journal of nutrition Controlled trial quality: uncertain

22412. Bioavailability of calcium supplements and the effect of Vitamin D: comparisons between milk, calcium carbonate, and calcium carbonate plus vitamin D. Full Text available with Trip Pro

Bioavailability of calcium supplements and the effect of Vitamin D: comparisons between milk, calcium carbonate, and calcium carbonate plus vitamin D. Our aim was to examine a regimen for calcium supplementation because various factors seem to be important for its bioavailability, and to examine the effect of adding vitamin D to the supplement. The participants were 20 healthy women aged 28-59 y (chi: 38 y). During the 3-d periods and 1 d before, the participants were consuming a calcium (...) and energy-balanced diet as similar to their usual daily diet as possible. The study was designed as a randomized, placebo-controlled, partly blinded crossover study divided into four periods of 3 d each: 1) three tablets containing 1000 mg CaCO3/d, 2) three tablets containing 1000 mg CaCO3 plus 5 micrograms (200 IU) vitamin D/d, 3)1 L more milk than in the usual daily diet, and 4) three placebo tablets daily. Bioavailability of the different calcium-supplement regimens were evaluated by changes in 24-h

1996 The American journal of clinical nutrition Controlled trial quality: uncertain

22413. Increased oxidation resistance of atherogenic plasma lipoproteins at high vitamin E levels in non-vitamin E supplemented men. (Abstract)

Increased oxidation resistance of atherogenic plasma lipoproteins at high vitamin E levels in non-vitamin E supplemented men. The oxidative modification of human low density lipoprotein (LDL) has been widely investigated. However, there are no data concerning the oxidation susceptibility of combined very low density lipoprotein (VLDL), intermediate density lipoprotein (IDL) and low density lipoprotein fraction, although all of them are atherogenic and contain antioxidants such as alpha (...) -tocopherol. We investigated the oxidation susceptibility and oxidation resistance of VLDL + LDL (including IDL) fraction by induction with CuCl2 and its relation to plasma alpha-tocopherol concentration and lipid standardised alpha-tocopherol concentration in 406 non-vitamin E-supplemented men from eastern Finland. Even thought we did not give oral vitamin E or any other antioxidant supplementation to our study participants, we observed a significant, consistent relationship between measurements

1996 Atherosclerosis Controlled trial quality: uncertain

22414. Vitamin A status of Indonesian children infected with Ascaris lumbricoides after dosing with vitamin A supplements and albendazole. Full Text available with Trip Pro

Vitamin A status of Indonesian children infected with Ascaris lumbricoides after dosing with vitamin A supplements and albendazole. In developing countries, both marginal vitamin A status and intestinal helminths are common among children. Indonesian children (n = 309, 0.6-6.6 y), known to be infected with Ascaris lumbricoides, were randomized into six different treatment groups (A-F). The treatments included 210 mumol vitamin A supplement and a dose of 400 mg albendazole (5-propylthio-1H (...) -benzimidazol-2-yl carbamic acid methyl ester) administered orally either at the same health visit (Groups B and F) or at different contact times during a 1-mo period (groups A, C, D and E). Vitamin A status was assessed both before and 3-4 wk after the treatments by the modified relative dose response (MRDR) test. Vitamin A supplementation was most important in improving the vitamin A status (P < 0.0001) of these children, whereas treatment for ascariasis alone (P = 0.370) and the statistical interaction

1996 The Journal of nutrition Controlled trial quality: uncertain

22415. Vitamin-E supplements and their effect on vitamin-E status in blood and genetic damage rate in peripheral blood lymphocytes. (Abstract)

Vitamin-E supplements and their effect on vitamin-E status in blood and genetic damage rate in peripheral blood lymphocytes. A placebo-controlled double-blind intervention trial was performed using 60 male volunteers aged between 50 and 70 years to test the hypothesis that intake of d-alpha-tocopherol (VITE) above the recommended dietary intake (RDI) level (10.0 mg or 14.9 IU VITE) can protect against DNA damage in human peripheral blood lymphocytes. The intervention consisted of two phases (...) , each of 8 weeks duration: during the initial phase the VITE supplement was 5 x RDI (provided in cereal) and during the second phase the VITE supplement was 30 x RDI (provided in capsules). Blood samples were collected before the initial phase, between phases and at the end of the second phase; the level of VITE was measured in plasma using HPLC and genetic damage rate in peripheral blood lymphocytes was measured using the cytokinesis-block micronucleus assay. The study has shown that cereal

1997 Carcinogenesis Controlled trial quality: uncertain

22416. Effect of vitamin K1 supplementation on vitamin K status in cystic fibrosis patients. (Abstract)

Effect of vitamin K1 supplementation on vitamin K status in cystic fibrosis patients. Patients with cystic fibrosis are at risk for impaired vitamin K status due to fat malabsorption from pancreatic insufficiency. This study was designed to assess vitamin K status and measure the effect of vitamin K1 supplementation in cystic fibrosis patients.Eighteen outpatients participated in a crossover study to determine the effect of vitamin K1 (phylloquinone) supplementation. After obtaining initial (...) data, each subject was randomly assigned to either a 4-week study treatment of 5 mg oral vitamin K1 supplementation per week, or no supplementation and then crossed over to the other treatment for a second 4 week period. Plasma, serum and urine samples were collected and analyzed pre-study and at the end of each study period.The mean concentration of plasma vitamin K1 for the supplemented group was significantly higher than the unsupplemented group, [0.34 nmol/L and 0.21 nmol/L, respectively (p

1997 Journal of pediatric gastroenterology and nutrition Controlled trial quality: uncertain

22417. Effects of trace element and/or vitamin supplementation on vitamin and mineral status, free radical metabolism and immunological markers in elderly long term-hospitalized subjects. Geriatric Network MIN. VIT. AOX. (Abstract)

Effects of trace element and/or vitamin supplementation on vitamin and mineral status, free radical metabolism and immunological markers in elderly long term-hospitalized subjects. Geriatric Network MIN. VIT. AOX. A randomized double-blind trial was performed in order to assess the efficacity of differing combinations of antioxidant nutrients on biochemical parameters of vitamin and trace element status, immunological parameters and free radical metabolism in elderly long term hospitalized (...) and 1 year of supplementation. Some immunological markers were investigated initially and after 6 months of supplementation on a subsample of 134 subjects. Mean plasma levels of alpha-tocopherol, gamma-tocopherol, vitamin C, alpha-carotene, beta-carotene and copper increased significantly after 6 months of supplementation in groups receiving vitamins alone or associated with trace elements. Serum selenium concentrations were significantly increased at 6 months of supplementation, and serum zinc only

1997 International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition Controlled trial quality: uncertain

22418. Improving the vitamin K status of breastfeeding infants with maternal vitamin K supplements. (Abstract)

Improving the vitamin K status of breastfeeding infants with maternal vitamin K supplements. To increase the phylloquinone (vitamin K1) concentration of human milk with maternal oral phylloquinone supplements such that both the phylloquinone intake of breastfed infants and their serum concentrations of phylloquinone would approach those of formula-fed infants who are known to be at much less risk for hemorrhagic disease of the newborn.Two stages: stage I, longitudinal, randomized study of 6 (...) received 1 mg of phylloquinone at birth. Eleven mothers received a placebo; 11 mothers received 5 mg/d phylloquinone.In stage I, both 2.5 and 5.0 mg/d phylloquinone significantly increased the phylloquinone content of human milk at both 2 and 6 weeks. As expected, 5.0 mg had a greater effect (mean +/- SD, 58.96 +/- 25.39 vs 27.12 +/- 12.18 ng/mL at 2 weeks). In stage II, the vitamin K-supplemented group had significantly higher maternal serum phylloquinone concentrations, higher phylloquinone milk

1997 Pediatrics Controlled trial quality: predicted high

22419. Background and rationale behind the SU.VI.MAX Study, a prevention trial using nutritional doses of a combination of antioxidant vitamins and minerals to reduce cardiovascular diseases and cancers. SUpplementation en VItamines et Minéraux AntioXydants Stu (Abstract)

Background and rationale behind the SU.VI.MAX Study, a prevention trial using nutritional doses of a combination of antioxidant vitamins and minerals to reduce cardiovascular diseases and cancers. SUpplementation en VItamines et Minéraux AntioXydants Stu The "SUpplementation en VItamines et MinérauxAntioXydants" (SU.VI.MAX) study is a randomized double-blind, placebo-controlled, primary prevention trial designed to test the efficacy of daily supplementation with antioxidant vitamins (vitamin C (...) , 120 mg; vitamin E, 30 mg; and beta-carotene, 6 mg) and minerals (selenium, 100 micrograms; and zinc, 20 mg), at nutritional doses (one to three times the daily recommended dietary allowances), in reducing the frequency of major health problems in industrialized countries, and especially the main causes of premature death (cancers and cardiovascular diseases). The study involves 12,735 eligible subjects (women aged 35 to 60 years; men aged 45 to 60 years) included in 1994 in France

1998 International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition Controlled trial quality: predicted high

22420. Serum levels of 1,25-(OH)2-vitamin D are not altered by long-term supplementation with alphacalcidol (1-OH-vitamin D3). A double-blind, placebo-controlled study. (Abstract)

Serum levels of 1,25-(OH)2-vitamin D are not altered by long-term supplementation with alphacalcidol (1-OH-vitamin D3). A double-blind, placebo-controlled study. The endogenous production of 1,25-(OH)2-vitamin D has been estimated to be 1.5 micrograms daily. Despite the use of alphacalcidol (1,25-(OH)2-vitamin D) during more than a decade the long-term effects of the serum levels of 1,25-(OH)2-vitamin D have been poorly investigated. When 1 microgram of alphacalcidol was given daily to 39 non (...) -vitamin D deficient subjects in a double-blind, placebo-controlled study during 4 months no significant effects on the serum levels of 1,25-(OH)2-vitamin D or 25-(OH)-vitamin D were found. The treatment however induced a 50% increase in urinary excretion of calcium (p less than 0.01). In conclusion, long-term supplementation with a physiological dose of alphacalcidol does not influence the serum levels of 1,25-(OH)2-vitamin D, despite a marked effect on urinary calcium excretion.

1992 Experimental and clinical endocrinology Controlled trial quality: uncertain

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