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Vitamin B12 Supplementation

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22381. Supplementation with a combination of omega-3 fatty acids and antioxidants (vitamins E and C) improves the outcome of schizophrenia. (Abstract)

Supplementation with a combination of omega-3 fatty acids and antioxidants (vitamins E and C) improves the outcome of schizophrenia. Reduced levels of membrane essential polyunsaturated fatty acids (EPUFAs), namely, arachidonic acid (AA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acids (DHAs), and their association with psychopathology have been consistently reported in both chronic-medicated schizophrenic patients as well as in never-medicated patients soon (...) after the first episode of psychosis. Past supplementation studies with either omega-6 or omega-3 or both EPUFAs generally in chronic-medicated-older patients have reported varying degrees of therapeutic effects, and have suggested that supplementation with primarily omega-3 EPUFAs (EPA>DHA) may be preferable. We report the supplementation with a mixture of EPA/DHA (180:120 mg) and antioxidants (vitamin E/C, 400 IU:500 mg) orally morning and evening to schizophrenic patients (N=33) for 4 months

2003 Schizophrenia Research

22382. Antenatal vitamin A supplementation increases birth weight and decreases anemia among infants born to human immunodeficiency virus-infected women in Malawi. Full Text available with Trip Pro

Antenatal vitamin A supplementation increases birth weight and decreases anemia among infants born to human immunodeficiency virus-infected women in Malawi. Vitamin A is essential for immunity and growth. A controlled clinical that involved 697 human immunodeficiency virus (HIV)-infected pregnant women was conducted to determine whether vitamin A prevents anemia, low birth weight, growth failure, HIV transmission, and mortality. Women received daily doses of iron and folate, either alone (...) or combined with vitamin A (3 mg retinol equivalent), from 18-28 weeks' gestation until delivery. In the vitamin A and control groups, respectively, the mean (+/-SE) birth weights were 2895+/-31 g and 2805+/-32 g (P=.05), the proportions of low-birth-weight infants were 14.0% and 21.1% (P=.03), the proportions of anemic infants at 6 weeks postpartum were 23.4% and 40.6% (P<.001), and the respective cumulative proportions of infants who were HIV infected at 6 weeks and 24 months of age were 26.6% and 27.8

2002 Clinical Infectious Diseases

22383. Vitamin K supplementation in cystic fibrosis. Full Text available with Trip Pro

Vitamin K supplementation in cystic fibrosis. The relation between different doses of vitamin K supplementation, several bone markers, and PIVKA-II concentrations in cystic fibrosis (CF) patients compared to controls was evaluated. Results suggest that a increased vitamin K intake may have significant health benefits for children with CF.

2003 Archives of Disease in Childhood

22384. Supplementation with vitamin E fails to attenuate oxidative damage in aged mice. (Abstract)

Supplementation with vitamin E fails to attenuate oxidative damage in aged mice. The validity of the oxidative stress hypothesis of aging has sometimes been questioned because the administration of low molecular weight antioxidants such as alpha-tocopherol does not retard the aging process and extend maximum life span. Thus, the goal of the current study was to determine if increased oral intake of alpha-tocopheryl acetate indeed results in its augmentation in tissues or in their mitochondria (...) , and whether or not this causes an attenuation of oxidative damage. Groups of relatively old (21 months) experimental mice were fed a diet supplemented with 1.65 g/kg alpha-tocopheryl acetate or the base diet (NIH-31), for 13 weeks. Supplementation with alpha-tocopheryl acetate increased alpha-tocopherol concentrations approximately 3-5-fold in plasma and in tissue homogenates and approximately 2-3-fold in mitochondria from liver, skeletal muscle and heart of the mice. However, supplementation affected

2003 Experimental Gerontology

22385. Vitamin C and E supplementation in women at risk of preeclampsia is associated with changes in indices of oxidative stress and placental function. (Abstract)

Vitamin C and E supplementation in women at risk of preeclampsia is associated with changes in indices of oxidative stress and placental function. We have previously reported a reduced incidence of preeclampsia in women who were at risk and were taking vitamin C (1000 mg/d) and vitamin E (400 IU/d) supplements. In this study, we determined whether supplementation in the same cohort was associated with an improvement in indices of placental dysfunction and oxidative stress toward values (...) determined in women who were at low risk of preeclampsia.Seventy-nine women who were at high risk and who were taking vitamin supplements and 81 who were taking placebos were compared with 32 women who were at low risk and who were not taking supplements who were studied simultaneously.Indices of oxidative stress and placental function were abnormal in the placebo group. When the placebo group was compared with the women who were at low risk, ascorbic acid, plasminogen activator inhibitor-2, and placenta

2002 American Journal of Obstetrics and Gynecology

22386. A prospective study on supplemental vitamin e intake and risk of colon cancer in women and men. (Abstract)

A prospective study on supplemental vitamin e intake and risk of colon cancer in women and men. We conducted a prospective study on the association between supplemental vitamin E and colon cancer in 87,998 females from the Nurses' Health Study and 47, 344 males from the Health Professionals Follow-up Study. There was some suggestion that men with supplemental vitamin E intake of 300 IU/day or more may be at lower risk for colon cancer when compared with never users [multivariate relative risk (...) (RR), 300-500 IU/day versus never users, 0.73 (95% confidence interval (CI), 0.52-1.03); >or=600 IU/day versus never users = 0.70 (95% CI = 0.38-1.29)], but CIs included 1. In women, there was no evidence for an inverse association between vitamin E supplementation and risk of colon cancer. Our findings do not provide consistent support for an inverse association between supplemental vitamin E and colon cancer risk. Considering the paucity of epidemiological data on this association, further

2002 Cancer Epidemiology & Biomarkers and Prevention

22387. Effects of vitamin supplementation and hyperhomocysteinemia on atherosclerosis in apoE-deficient mice. (Abstract)

Effects of vitamin supplementation and hyperhomocysteinemia on atherosclerosis in apoE-deficient mice. It has been demonstrated that hyperhomocysteinemia (HHcy) accelerates atherosclerosis in apolipoprotein E-deficient (apoE(-/-)) mice. In this study, vitamin-defined chow diets were used to induce HHcy in apoE(-/-) mice in an attempt to identify possible pathogenic pathways. Six-week-old female apoE(-/-) mice were divided into seven groups: vitamin-defined purified chow diet alone (control (...) ), or same diet supplemented with either D,L-homocysteine (upward arrow Hcy) or L-homocystine (upward arrow Hcy-Hcy), or diet high in L-methionine (upward arrow Met), or diet high in B-vitamins (upward arrow vitamin), or diets deficient in folate (downward arrow folate) or vitamin B(6) ( downward arrow B(6)). Eighteen weeks later, plasma total homocysteine (tHcy), lipids and atherosclerotic plaque burden (aortic root, aortic arch, and brachiocephalic trunk) were measured. tHcy levels were similar

2003 Atherosclerosis

22388. Dietary supplementation with vitamins C and E prevents downregulation of endothelial NOS expression in hypercholesterolemia in vivo and in vitro. (Abstract)

Dietary supplementation with vitamins C and E prevents downregulation of endothelial NOS expression in hypercholesterolemia in vivo and in vitro. Impaired endothelium-dependent vasodilation has been associated with decreased NO bioavailability in hypercholesterolemia. This study aimed to determine whether antioxidant vitamins C and E could improve hypercholesterolemia-derived endothelial dysfunction in the porcine model, and whether observed in vivo results could be reproduced in vitro (...) by incubation of coronary endothelial cells (EC) in the presence of native low-density lipoproteins (LDL). Adult mini-pigs were fed standard (C), cholesterol rich (HC) or cholesterol rich diet supplemented with vitamins C and E (HCV). Endothelium-dependent blood flow increase in response to acetylcholine was determined. Endothelial nitric oxide synthase (eNOS) expression was measured in arterial samples and in EC incubated with LDL isolated from porcine plasma. Vasomotor response to acetylcholine in HC

2002 Atherosclerosis

22389. A cost effectiveness analysis of calcium and vitamin D supplementation, etidronate, and alendronate in the prevention of vertebral fractures in women treated with glucocorticoids. (Abstract)

A cost effectiveness analysis of calcium and vitamin D supplementation, etidronate, and alendronate in the prevention of vertebral fractures in women treated with glucocorticoids. To assess the relative costs and benefits of calcium and vitamin D supplements, cyclic etidronate, or alendronate in the prevention of vertebral fractures for women and with normal bone density and osteopenia who are about to initiate moderate dose glucocorticoid treatment.Using a decision analysis model, we evaluated (...) ) and direct and indirect costs.At 10 years, calcium and vitamin D supplements decreased fracture rates by 30-50% at a minimal cost (US$800 or less per vertebral fracture avoided) or at a cost saving compared to no treatment for women with osteopenia (t score -1 to -2). Etidronate and alendronate are most cost effective in women with borderline osteoporosis (t scores of -1.5 and -2) in the 10 year analysis. In the life-time analysis, calcium and vitamin D treatment yielded a cost savings compared

2003 Journal of Rheumatology

22390. Pregnancy in mice lacking the vitamin D receptor: normal maternal skeletal response, but fetal hypomineralization rescued by maternal calcium supplementation. Full Text available with Trip Pro

Pregnancy in mice lacking the vitamin D receptor: normal maternal skeletal response, but fetal hypomineralization rescued by maternal calcium supplementation. Fetal mineralization appears to be driven by the pregnancy-induced stimulation of intestinal Ca absorption. We thus hypothesized that mineralization would be impaired in fetuses of mice that lack the vitamin D receptor (VDR). Here we report on the maternal response to pregnancy, and the fetal mineralization, in mice with a homozygous

2003 Pediatric Research

22391. Improvement in bronchial squamous metaplasia in smokers treated with folate and vitamin B12. Report of a preliminary randomized, double-blind intervention trial. (Abstract)

Improvement in bronchial squamous metaplasia in smokers treated with folate and vitamin B12. Report of a preliminary randomized, double-blind intervention trial. To test whether changes in folate and vitamin B12 nutrition modify the severity of potentially premalignant lesions identified by cytology in sputum samples of smokers, we conducted a randomized, controlled prospective intervention trial in smokers with bronchial squamous metaplasia. Seventy-three men with a history of 20 or more pack (...) with folate and vitamin B12. However, the significance of these findings is tempered by substantial spontaneous variation in sputum cytologies, the small study population, the short duration of the trial, and the supraphysiological doses of folate and B12 used. The results should not be construed as pointing to a potential way of preventing lung cancer in individuals who continue to smoke or as supporting self-medication with large doses of folate or B12 by smokers.

1988 JAMA Controlled trial quality: uncertain

22392. Importance of both folic acid and vitamin B12 in reduction of risk of vascular disease. (Abstract)

Importance of both folic acid and vitamin B12 in reduction of risk of vascular disease. Fortification of food with folic acid to prevent neural-tube defects in babies also lowers plasma total homocysteine, which is a risk factor for vascular disease. We investigated the effect of folate and vitamin B12 on homocysteine concentrations. 30 men and 23 women received sequential supplementation with increasing doses of folic acid. After supplementation, the usual dependency of homocysteine on folate (...) diminished, and vitamin B12 became the main determinant of plasma homocysteine concentration. This finding suggests that a fortification policy based on folic acid and vitamin B12, rather than folic acid alone, is likely to be much more effective at lowering of homocysteine concentrations, with potential benefits for reduction of risk of vascular disease.

2002 Lancet

22393. Folate and B12 Levels: Are Supplements Given Too Late? Full Text available with Trip Pro

Folate and B12 Levels: Are Supplements Given Too Late? 21274189 2012 10 02 2018 11 13 0008-350X 31 1985 Oct Canadian family physician Medecin de famille canadien Can Fam Physician Folate and b(12) levels: are supplements given too late? 1808 Leyton E E eng Journal Article Canada Can Fam Physician 0120300 0008-350X 2011 1 29 6 0 1985 10 1 0 0 1985 10 1 0 1 ppublish 21274189 PMC2327869 Can Fam Physician. 1985 Aug;31:1523-6 21274038

1985 Canadian Family Physician

22394. Randomised trial to assess benefits and safety of vitamin A supplementation linked to immunisation in early infancy. WHO/CHD Immunisation-Linked Vitamin A Supplementation Study Group. (Abstract)

Randomised trial to assess benefits and safety of vitamin A supplementation linked to immunisation in early infancy. WHO/CHD Immunisation-Linked Vitamin A Supplementation Study Group. The benefits and safety of vitamin A supplementation linked to immunisation in infancy need to be assessed before it can be widely recommended. We assessed the safety and benefits of maternal postpartum and infant vitamin A supplementation administered with each of the three diphtheria-tetanus-pertussis (DPT (...) ) and poliomyelitis immunisations and with a fourth dose with measles immunisation.From January, 1995, we enrolled 9424 mother-infant pairs from Ghana, India, and Peru in this randomised, double-blind, placebo-controlled trial. 4716 mothers of infants in the vitamin A group received 200000 IU vitamin A, and their infants were given 25000 IU vitamin A with each of the first three doses of DPT/poliomyelitis immunisation at 6, 10, and 14 weeks. In the control group, 4708 mothers and their infants received placebo

1998 Lancet Controlled trial quality: predicted high

22395. In vitamin b12 deficiency, where the patient is intrinsic factor (IF) and parietal cell antibody negative, should they be treated with oral vitamin b12?

supplements following acute treatment, although a twice-yearly injection is an alternative.” It later reports: “Oral vitamin B12 (cyanocobalamin) is included. It is suitable only for the very small minority of people with proven dietary deficiency of vitamin B12 (most vitamin B12 deficiency is due to malabsorption). It is available on an NHS prescription only for this indication, and the prescription must be endorsed 'SLS'.” You may also be interested in the CKS comments on the IF and parietal cell (...) In vitamin b12 deficiency, where the patient is intrinsic factor (IF) and parietal cell antibody negative, should they be treated with oral vitamin b12? In vitamin b12 deficiency, where the patient is intrinsic factor (IF) and parietal cell antibody negative, should they be treated with oral vitamin b12? - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document

2008 TRIP Answers

22396. Effect of Homocysteine-Lowering Therapy With Folic Acid, Vitamin B12, and Vitamin B6 on Endothelium-Dependent Vasodilatation of Forearm Resistance Vessels in Patients With Coronary Heart Disease

with cardiovascular disease. Condition or disease Intervention/treatment Phase Cardiovascular Disease Endothelial Dysfunction Drug: folic acid, vitamin B12 and B6 and rosuvastatin Phase 2 Detailed Description: Study design: 36 pts with CAD or PAD are randomly assigned to either rosuvastatin 10mg/d or vitamin supplementation with folic acid 1mg, vitamin B12 0.4mg and B6 10mg/d for 6 weeks in a double-blinded design. After 6 weeks all pts receive rosuvastatin and vitamin supplementation in combination (...) With Coronary Heart Disease Study Start Date : January 2005 Actual Primary Completion Date : February 2007 Actual Study Completion Date : April 2007 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: R Rosuvastatin treatment for 6 weeks and after that combined treatment with rosuvastatin and vitamin supplementation for additional 6 weeks Drug: folic acid, vitamin B12 and B6 and rosuvastatin

2008 Clinical Trials

22397. Folic acid and vitamin B12 are more effective than vitamin B6 in lowering fasting plasma homocysteine concentration in patients with coronary artery disease. Full Text available with Trip Pro

Folic acid and vitamin B12 are more effective than vitamin B6 in lowering fasting plasma homocysteine concentration in patients with coronary artery disease. To investigate whether vitamin B(6) supplementation had a beneficial effect on lowering fasting plasma homocysteine concentrations in coronary artery disease (CAD) patients.A single-blind intervention study.The study was performed at the Taichung Veterans General Hospital, the central part of Taiwan.A total of 50 subjects were identified (...) the intervention (week 0) and at week 12. Vitamin B(6) status was assessed by direct measures (plasma pyridoxal 5'-phosphate) and indirect measures (erythrocyte alanine and aspartate aminotransaminase activity coefficient). Fasting plasma homocysteine, serum folic acid, and vitamin B(12) were measured.Fasting plasma homocysteine concentration did not respond to high or low doses of vitamin B(6) when compared with a placebo treatment after 12 weeks of supplementation. The mean fasting plasma homocysteine

2004 European journal of clinical nutrition Controlled trial quality: uncertain

22398. Are there any adverse effects to taking vitamin B12 supplements if you are not actually deficient?

Are there any adverse effects to taking vitamin B12 supplements if you are not actually deficient? Are there any adverse effects to taking vitamin B12 supplements if you are not actually deficient? - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe (...) across other content types including images, videos, patient information leaflets, educational courses and news. For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com Are there any adverse effects to taking vitamin B12 supplements if you are not actually deficient? The National Institute of Health has produced a Dietary Supplement Factsheet on vitamin B12 (1

2005 TRIP Answers

22399. A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa. (Abstract)

A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa. 8240092 1993 12 07 2015 04 17 0003-9950 111 11 1993 Nov Archives of ophthalmology (Chicago, Ill. : 1960) Arch. Ophthalmol. A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa. 1460; author reply 1463-5 Norton E W EW eng Clinical Trial Comment Comparative Study Letter United States Arch Ophthalmol 7706534 0003-9950 11103-57-4 Vitamin A 1406-18-4 Vitamin E AIM IM Arch (...) Ophthalmol. 1993 Jun;111(6):761-72 8512476 Humans Research Design Retinitis Pigmentosa drug therapy Vitamin A therapeutic use Vitamin E therapeutic use 1993 11 1 1993 11 1 0 1 1993 11 1 0 0 ppublish 8240092

1993 Archives of ophthalmology (Chicago, Ill. : 1960) Controlled trial quality: uncertain

22400. A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa. (Abstract)

A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa. 8240093 1993 12 07 2015 04 17 0003-9950 111 11 1993 Nov Archives of ophthalmology (Chicago, Ill. : 1960) Arch. Ophthalmol. A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa. 1460-1; author reply 1463-5 Marmor M F MF eng Clinical Trial Comment Comparative Study Letter United States Arch Ophthalmol 7706534 0003-9950 11103-57-4 Vitamin A 1406-18-4 Vitamin E AIM IM Arch (...) Ophthalmol. 1993 Jun;111(6):761-72 8512476 Data Interpretation, Statistical Humans Research Design Retinitis Pigmentosa drug therapy Vitamin A therapeutic use Vitamin E adverse effects therapeutic use 1993 11 1 1993 11 1 0 1 1993 11 1 0 0 ppublish 8240093

1993 Archives of ophthalmology (Chicago, Ill. : 1960) Controlled trial quality: uncertain

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