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Vitamin B12 Supplementation

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22361. Effect of supplementation with vitamin D3 and calcium on quantitative ultrasound of bone in elderly institutionalized women: a longitudinal study. (Abstract)

Effect of supplementation with vitamin D3 and calcium on quantitative ultrasound of bone in elderly institutionalized women: a longitudinal study. Supplementation of elderly institutionalized women with vitamin D and calcium decreased hip fractures and increased hip bone mineral density. Quantitative ultrasound (QUS) measurements can be performed in nursing homes, and easily repeated for follow-up. However, the effect of the correction of vitamin D deficiency on QUS parameters is not known (...) ), and decreased by 2.3% in the controls (p < 0.01). Therefore, the difference in BUA between the treated subjects and the controls (3.9%) was significant after 2 years (p < 0.01). However, SOS decreased by the same amount in both groups (approximately 0.5%). In conclusion, BUA, but not SOS, reflected the positive effect on bone of supplementation with calcium and vitamin D3 in a population of elderly institutionalized women.

1999 Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

22362. Vitamin E supplementation and respiratory effects of ozone in humans. (Abstract)

Vitamin E supplementation and respiratory effects of ozone in humans. To determine whether vitamin E (di-alpha-tocopherol) supplementation could protect against short-term respiratory responses to O3 exposure its effects were investigated in young healthy adult volunteers. Experimental groups received 800 or 1600 IU vitamin E per day for 9 or more wk, while control groups received placebo. Subjects were then exposed for 2-h periods to 0.5 ppm O3, with secondary stresses of heat and intermittent (...) light exercise. Responses to O3 exposure, evaluated in terms of symptoms, forced expiratory performance, and single-breath nitrogen washout, were not significantly different between vitamin E and placebo groups.

1981 Journal of toxicology and environmental health

22363. Vitamin D supplements enhance weight gain and nutritional status in pregnant Asians. (Abstract)

Vitamin D supplements enhance weight gain and nutritional status in pregnant Asians. In a double blind trial of supplementary vitamin D (1000 iu daily) administered in the last trimester of pregnancy to Asian women living in London, supplemented mothers gained weight faster (63.3 g/day) than those in the control group (46.4 g/day), and at term had significantly higher plasma levels of retinol binding protein and thyroid binding prealbumin indicating better protein-calorie nutrition. Maternal (...) weight gain correlated with postpartum levels of both retinol binding protein and thyroid binding prealbumin. Almost twice as many infants in the unsupplemented group weighed under 2500 g at birth, and had significantly lower retinol binding protein levels than infants of supplemented mothers. The nutritional benefits of supplementation provide further support for the routine administration of vitamin D to all British Asians during pregnancy.

1981 British journal of obstetrics and gynaecology

22364. Effect of vitamin C supplements on cell-mediated immunity in old people. Full Text available with Trip Pro

Effect of vitamin C supplements on cell-mediated immunity in old people. Both ageing and vitamin C (VC) deficiency result in immune defect. Since low serum and tissue levels of VC are found in the elderly, we have in a placebo-controlled study, tested the effect of VC supplements (500 mg/day i.m. for 1 month) on various immune parameters. Indeed, VC enhances the proliferative response of T lymphocytes in vitro, and the tuberculin skin hypersensitivity in vivo. Neither the serum concentrations

1983 Gerontology

22365. The clinical and biochemical effects of vitamin C supplementation in short-stay hospitalized geriatric patients. (Abstract)

of plasma and leucocyte (buffy layer) vitamin C, plasma folate, vitamin B12, cortisol and total white cell count. Plasma and leucocyte vitamin C levels remained low for several weeks in a substantial proportion of the non-supplemented patients, whereas low levels were virtually eliminated in the supplemented group. The results from this study suggest that the leucocyte vitamin C levels may give some indication of prognosis in this category of patients (ie. "acute" geriatric admissions) as evidenced (...) The clinical and biochemical effects of vitamin C supplementation in short-stay hospitalized geriatric patients. A double-blind placebo trial has been undertaken on 199 elderly patients admitted to an "acute" geriatric assessment ward. Clinical and biochemical assessment was made on admission (0) and at 2, 4, 8, 16 and 24 weeks (after admission). Ninety-four patients were supplemented with vitamin C (200 mg per day) and 105 had placebo tablets. Biochemical assessment included estimations

1984 International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition

22366. Vitamin-mineral supplement fails to improve IQ of mentally retarded young adults. (Abstract)

Vitamin-mineral supplement fails to improve IQ of mentally retarded young adults. Twenty mentally retarded persons participated in a study to determine the effect of large doses of vitamin-mineral supplements on IQ, educability, electrophysiological responsiveness, and pyridoxine metabolism. Using a double-blind matched group experimental design, we administered supplements and placebos for 6 months. Pre- and postmeasurements showed no significant effects on any of the measured variables.

1984 American journal of mental deficiency

22367. [Prevention of second primary cancer with vitamin supplementation in patients treated for head and neck cancers]. (Abstract)

[Prevention of second primary cancer with vitamin supplementation in patients treated for head and neck cancers]. Second primary cancers often occur in head and neck cancer patients successfully treated by radiation therapy. Experimental and epidemiological data suggest that these second primaries might be prevented by antioxidant vitamins, in particular beta-carotene and alpha-tocopherol. A randomized double-blind clinical trial is being conducted in Canada to determine whether vitamin (...) supplementation with beta-carotene (30 mg/d) and alpha-tocopherol (400 IU/d) reduces the incidence of second primaries in head and neck cancer patients treated by radiation therapy.

1996 Bulletin du cancer. Radiothérapie : journal de la Société française du cancer : organe de la société française de radiothérapie oncologique

22368. The effect of vitamin C supplementation on diabetic hyperlipidaemia: a double blind, crossover study. (Abstract)

The effect of vitamin C supplementation on diabetic hyperlipidaemia: a double blind, crossover study. Fifty diabetic patients took part in a four-month, double-blind crossover study comparing 500 mg of vitamin C daily with placebo. No significant difference was observed between vitamin C and placebo therapy in fasting whole blood glucose, serum cholesterol, triglycerides, and glycosylated haemoglobin levels.

1985 Diabetic medicine : a journal of the British Diabetic Association Controlled trial quality: uncertain

22369. Vitamin E and selenium supplementation in geriatric patients : A double-blind preliminary clinical trial. (Abstract)

Vitamin E and selenium supplementation in geriatric patients : A double-blind preliminary clinical trial. Sodium selenate (8 mg/d), organic selenium (50 μg/d) andd-alpha-tocopherol acetate (400 mg/d) were administered for 1 yr to 15 geriatric patients. Fifteen comparable controls received placebo. The mean age of both groups was 76 yr. The patients were assessed every 2 mo independently by two nurses using the Sandoz Clinical Assessment Geriatric-scale (SCAG). The propositae, showed significant (...) improvement in the following SCAG parameters: depression, anxiety, self-care, mental alertness, emotional lability, motivation and initiative, hostility, interest in the environment, fatigue, anorexia, and general impression. A distinct improvement of the general condition was noticed after only 2 mo and the improvement continued up to the end of the 1-yr study period. The high selenium and vitamin E doses were well tolerated; there were no side effects whatsoever.

1985 Biological trace element research Controlled trial quality: uncertain

22370. Vitamin and mineral supplementation: effect on the running performance of trained athletes. (Abstract)

Vitamin and mineral supplementation: effect on the running performance of trained athletes. There is limited scientific justification for the widespread use of vitamin and mineral supplements by athletes. We used a 9-mo, placebo-controlled crossover study design to determine whether a multivitamin and mineral supplement influenced the athletic performance of 30 competitive male athletes. At 0, 3, 6, and 9 mo the runners performed a progressive treadmill test to volitional exhaustion (...) for measurement of maximal oxygen consumption, peak running speed, blood lactate turnpoint, and peak postexercise blood lactate level. Running time in a 15 km time trial was also measured. None of these variables was influenced by 3 mo of active supplementation. We conclude that 3 mo of multivitamin and mineral supplementation was without any measurable ergogenic effect.

1988 The American journal of clinical nutrition

22371. [Effect of supplementation with peach palm as source of vitamin A: study with rats]. (Abstract)

[Effect of supplementation with peach palm as source of vitamin A: study with rats]. The effect of supplementation with peach palm (Bactris gasipaes H.B.K.), as an alternative source of vit. A, in the regional diet of Manaus, AM, Brazil, in which the pulp was cooked and transformed into flour, was studied. The biological trial involved rats which were depleted in zinc and vitamin A, followed by repletion using the regional diet (RD), RD plus peach palm and RD plus vitamin A. The parameters used (...) which consumed the diet based on the regional diet of Manaus supplemented with either peach palm or vitamin A showed a significantly greater concentration of vitamin A in the liver, 43.3 +/- 6.5 micrograms/g, 42.0 +/- 4.3 micrograms/g, respectively in relation to the regional diet, 5.5 +/- 1.1 micrograms/g (p < 0.05). The amount of zinc present in the regional diet, 10.7 mg per day, was bioavailable as determined by the concentration of zinc in the femurs. The results suggest that the regional diet

1996 Revista de saúde pública

22372. The effect of modest vitamin E supplementation on lipid peroxidation products and other cardiovascular risk factors in diabetic patients. (Abstract)

The effect of modest vitamin E supplementation on lipid peroxidation products and other cardiovascular risk factors in diabetic patients. Among many factors, elevated lipids and lipid peroxide levels in blood are major risk factors in the development of cardiovascular disease in diabetic patients. This study has examined whether oral supplementation of vitamin E, an antioxidant, has any effect on blood lipid peroxidation products (LP) and lipid profile of diabetic patients. Thirty-five (...) diabetics(D) were supplemented with DL-alpha-tocopherol (E) capsule (orally, 100 IU/d) or placebo (P) for three months in double-blind clinical trials. Plasma E was analyzed by HPLC and LP by the thiobarbituric acid-reactivity; serum lipids by auto-analyzer. Data were analyzed using paired t-test and Wilcoxon Signed Rank Test. Vitamin E supplementation significantly lowered LP and lipid levels in diabetic patients; there were no differences in these parameters after P supplementation. There were

1996 Lipids

22373. Antioxidants in tears and plasma: Inter-relationships and effect of vitamin C supplementation. (Abstract)

Antioxidants in tears and plasma: Inter-relationships and effect of vitamin C supplementation. To investigate inter-relationships between total antioxidant capacity and ascorbate concentration in plasma and tears, and the effect of antioxidant supplementation with reference to these variables.Twenty-one subjects were studied in this placebo-controlled, cross-over intervention trial. Fasting plasma and tear ascorbate concentrations and total antioxidant capacity (as Ferric Reducing/Antioxidant (...) Power (FRAP)) were measured pre- and post-supplementation with vitamin C (1 g/day).Mean +/- SD ascorbate in tears and plasma at entry were 17 +/- 6 and 52 +/- 13 micro M, respectively; FRAP values were, respectively, 273 +/- 94 and 1101 +/- 168 micro M. There was no significant correlation between tear and plasma levels (r = -0.068; P = 0.771 for ascorbate; r = 0.418; P = 0.059 for FRAP). Neither was significant correlation seen between the two variables in plasma (r = 0.162; P = 0.483) or tears (r

2003 Current eye research

22374. Calcium-vitamin D3 supplementation is cost-effective in hip fractures prevention. (Abstract)

Calcium-vitamin D3 supplementation is cost-effective in hip fractures prevention. To assess the cost implications for a preventive treatment strategy for institutionalised elderly women with a combined 1200 mg/day calcium and 800 IU/day vitamin D(3) supplementation in seven European countries.Retrospective cost effectiveness analysis based on a prospective placebo-controlled randomised clinical trial.Recently published cost studies in seven European countries. Clinical results from Decalyos (...) , a 3-year placebo-controlled study in elderly institutionalised women.Decalyos study, with 36 months follow-up of 3270 mobile elderly women living in 180 nursing homes, allocated to two groups. One group received 1200 mg/day elemental calcium in the form of tricalcium phosphate together with 800 IU/day (20 microg) of cholecalciferol (vitamin D(3)), the other placebo.In the 36 months analysis of the Decalyos study, 138 hip fractures occurred in the group of 1176 women, receiving supplementation

2003 Maturitas

22375. Effects of vitamin E and C supplementation either alone or in combination on exercise-induced lipid peroxidation in trained cyclists. (Abstract)

Effects of vitamin E and C supplementation either alone or in combination on exercise-induced lipid peroxidation in trained cyclists. Seven trained male cyclists (ate 22.3 +/- 2 years) participated in 4 separate supplementation phases. They ingested 2 capsules per day containing the following treatments: placebo (placebo plus placebo); vitamin C (1 g per day vitamin C plus placebo); vitamin C and E (1 g per day vitamin C plus 200 IU per kg vitamin E); and vitamin E (400 IU per kg vitamin E plus (...) (MDA) and lactic acid. The results indicate that vitamin E treatment was more effective than vitamin C alone or vitamin C and E. Pre-exercise plasma levels of MDA in the vitamin E trial was 39% below the pre-exercise MDA levels of the placebo: 2.94 +/- 0.54 and 4.81 +/- 0.65 micromol per ml, respectively. Plasma MDA following exercise in the vitamin E group was also lower than teh placebo: 4.32 +/- 0.37 vs 7.89 +/- 1.0 micromol per ml, respectively. Vitamin C supplementation, on the other hand

2003 Journal of strength and conditioning research / National Strength & Conditioning Association

22376. Dietary supplementation with vitamin E in hyperlipoproteinemias: effects on plasma lipid peroxides, antioxidant activity, prostacyclin generation and platelet aggregability. (Abstract)

Dietary supplementation with vitamin E in hyperlipoproteinemias: effects on plasma lipid peroxides, antioxidant activity, prostacyclin generation and platelet aggregability. In a placebo-controlled trial healthy volunteers and patients with hyperlipoproteinemias types II and IV received orally vitamin E at doses of 300 mg and 600 mg daily for 2 weeks. Serum tocopherol levels increased two-fold, but serum concentrations of total lipids, cholesterol, triglycerides, ceruloplasmin and transferrin (...) remained unchanged. Dietary supplementation with vitamin E suppressed elevated concentrations of plasma lipid peroxides and this effect was correlated with an increase in serum antioxidant activity. In patients a mild platelet suppressant effect of vitamin E (600 mg daily) was observed. Feeding an atherogenic diet to rabbits for a week resulted in elevation of plasma lipid peroxides and a 90% decrease in arterial generation of prostacyclin. Enrichment of the atherogenic diet with 100 mg vitamin E daily

1985 Thrombosis and haemostasis

22377. Double blind study on the need for vitamin D supplementation in prepubertal children. (Abstract)

Double blind study on the need for vitamin D supplementation in prepubertal children. Fifty-one healthy prepubertal schoolchildren were followed for 13 months in a double blind study. Twenty-four of them were supplemented with 400 IU of vitamin D2 5-7 times weekly, while 27 received a placebo. The children were examined in winter both at the beginning and at the end of the study, and in the middle of the study in autumn. Mean 25-hydroxyvitamin D levels in the supplemented group were (...) significantly higher than those in the placebo group both in autumn and in winter, when the study ended. The vitamin D supplementation did not, however, affect other vitamin D metabolites, serum calcium, albumin, inorganic phosphorus, parathyroid hormone concentrations or alkaline phosphatase activity. Moreover, the supplementation caused no alterations in the weight or height gain or bone mineral content of the distal radius of the children, and thus subclinical rickets could not be shown.

1988 Acta paediatrica Scandinavica

22378. Supplementation with vitamin E but not beta-carotene in vivo protects low density lipoprotein from lipid peroxidation in vitro. Effect of cigarette smoking. (Abstract)

Supplementation with vitamin E but not beta-carotene in vivo protects low density lipoprotein from lipid peroxidation in vitro. Effect of cigarette smoking. Several lines of evidence suggest that oxidatively modified low density lipoprotein (LDL) is atherogenic and that antioxidants may protect LDL against oxidation. In addition, cigarette smoking is known to induce oxidant stress. We have examined the effect of ingestion of the antioxidants D,L-alpha-tocopherol (vitamin E) and beta-carotene (...) and of smoking on the resistance of LDL against copper-mediated oxidation. Six healthy nonsmoking volunteers ingested 1,000 IU/day D,L-alpha-tocopherol acetate for 7 days. After vitamin E ingestion concentrations of alpha-tocopherol in plasma and LDL increased 3.0- and 2.4-fold, respectively. Simultaneously, the oxidation resistance of LDL was elevated significantly (+41%), and the rate of oxidation was decreased significantly (-19%). The increase in alpha-tocopherol content of LDL and the increase

1992 Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association

22379. Hematological effect of supplementing anemic children with vitamin A alone and in combination with iron. Full Text available with Trip Pro

Hematological effect of supplementing anemic children with vitamin A alone and in combination with iron. Ninety-nine anemic children aged 1-8 y were divided into four groups. Each group was supplemented for 2 mo with vitamin A, iron, vitamin A plus Fe, or a placebo. Clinical, hematological, and Fe biochemical evaluations were performed at the beginning and end of the study. Vitamin A supplementation produced significant elevations in the serum levels of retinol, blood hemoglobin, hematocrit (...) , erythrocytes, serum Fe, and percent transferrin saturation (%TS) and had no effect on total Fe binding capacity (TIBC) or serum ferritin. Fe supplementation did not affect serum retinol. However, it improved hematological and Fe nutrition indicators, including TIBC and serum ferritin. The simultaneous administration of vitamin A and Fe resulted in a better response of serum Fe and %TS than when the supplement consisted only of vitamin A or Fe alone. Vitamin A benefits hematological condition and Fe

1988 The American journal of clinical nutrition

22380. Vitamin and mineral status in physically active men: effects of a high-potency supplement. (Abstract)

Vitamin and mineral status in physically active men: effects of a high-potency supplement. Changes in nutritional status during supplementation with a high-potency multivitamin-mineral supplement were examined in 22 physically active men randomly assigned to take a supplement (n = 11) or placebo (n = 11) for approximately 12 wk. Four-day dietary intakes, blood concentrations, and urinary excretions of selected vitamins and minerals were measured before, during (approximately 6 and 12 wk (...) ), and after supplementation. No changes were observed in blood concentrations of vitamins A and C and measures of zinc, magnesium, and calcium status; the supplement provided less than 300% of the recommended dietary allowance (RDA) of these nutrients. In contrast, blood concentrations of thiamin, riboflavin, vitamins B-6 and B-12, pantothenate, and biotin increased significantly (P less than 0.05) by 6 wk to values that were maintained until the end of the supplementation. These vitamins were provided

1992 The American journal of clinical nutrition Controlled trial quality: uncertain

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