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Vitamin B12 Supplementation

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1. Anaemia - B12 and folate deficiency: Scenario: Management of anaemia - vitamin B12 and folate deficiency

. Broccoli. Brown rice. Brussels sprouts. Chickpeas. Peas. For information on folic acid supplementation in pregnancy, see the CKS topic on . Basis for recommendation These recommendations are based on expert opinion in a chapter on Megaloblastic anaemia and miscellaneous deficiency anaemias in the medical textbook Oxford textbook of medicine [ ], a British Medical Journal (BMJ) best practice guide Folate deficiency [ ]. When should I refer a person with vitamin B12 or folate deficiency anaemia? Seek (...) B12 replete with adequate levels within the liver and so may safely stop taking vitamin B12 supplements for up to a year. Give dietary advice to all people — people on vegetarian, and especially vegan, diets should continue to take oral supplements. Basis for recommendation These recommendations are based on the British Society for Haematology (BSH) guidance on Vitamin B12 replacement during the COVID-19 pandemic [ ]. © .

2018 NICE Clinical Knowledge Summaries

2. Active B12 assay for diagnosing vitamin B12 deficiency

as on the length of the contract. ARCHITECT i2000SR and i1000SR analysers are commonly used in NHS laboratories. Likely place in therapy Currently vitamin B12 levels are tested when there is clinical suspicion of vitamin B12 deficiency and when monitoring patients during vitamin B12 supplementation therapy. The Active-B12 assay could be used as a replacement for the current standard test for serum total vitamin B12 levels. Holotranscobalamin levels may be more reliable than serum cobalamin in determining (...) Active B12 assay for diagnosing vitamin B12 deficiency Activ Active B12 assa e B12 assay for diagnosing vitamin B12 y for diagnosing vitamin B12 deficiency deficiency Medtech innovation briefing Published: 30 September 2015 nice.org.uk/guidance/mib40 pathways Summary Summary The Abbott ARCHITECT Active-B12 assay is a test for detecting levels of serum holotranscobalamin, which is the metabolically available component of vitamin B12, and can be used as a marker of vitamin B12 deficiency. Four

2015 National Institute for Health and Clinical Excellence - Advice

3. Long-term effects of folic acid and vitamin-B12 supplementation on fracture risk and cardiovascular disease: Extended follow-up of the B-PROOF trial. Full Text available with Trip Pro

Long-term effects of folic acid and vitamin-B12 supplementation on fracture risk and cardiovascular disease: Extended follow-up of the B-PROOF trial. In the initial B-proof, we found inconsistent results of B vitamin supplementation. However, the debate regarding the effects of B vitamins on age-related diseases continues. Therefore, our aim was to investigate the long-term effects (5-7 years follow-up) of an intervention with folic acid and vitamin-B12 supplementation on fracture (...) and cardiovascular disease risk.Extended follow-up of the B-PROOF trial, a multi-center, double-blind randomized placebo-controlled trial designed to assess the effect of 2-3 years daily supplementation with folic acid (400 μg) and vitamin-B12 (500 μg) versus placebo (n = 2,919). Primary outcome was verified self-reported fracture incidence and secondary outcomes were self-reported cardiovascular endpoints, which were collected through a follow-up questionnaires Proportional hazard analyses was used

2020 Clinical nutrition (Edinburgh, Scotland)

4. High-dose oral vitamin D supplementation and mortality in people aged 65 84 years: the VIDAL cluster feasibility RCT of open versus double-blind individual randomisation Full Text available with Trip Pro

High-dose oral vitamin D supplementation and mortality in people aged 65 84 years: the VIDAL cluster feasibility RCT of open versus double-blind individual randomisation High-dose oral vitamin D supplementation and mortality in people aged 65 84 years: the VIDAL cluster feasibility RCT of open versus double-blind individual randomisation Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested (...) could not be found. Please choose a page from the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} This study found that a full trial of vitamin D was feasible with either open or double blind randomisation. {{author}} {{($index , , , , , , , , , , , & . Christine Rake 1 , Clare Gilham 1 , Laurette Bukasa 1 , Richard Ostler 2 , Michelle Newton 3 , James Peto Wild 1

2020 NIHR HTA programme

5. Oral vitamin B12 – what are the prescribing considerations and what formulations are available?

to be launched in the UK in July 2020. Cyanocobalamin 50microgram tablets are available as Pharmacy only medicines or as food supplements. Cyanocobalamin tablets must be prescribed as “cyanocobalamin tablets” and should not be written as “vitamin B12 tablets”. In Wales, cyanocobalamin tablets can be prescribed for patients who are vegan or with a proven diet-related vitamin B12 deficiency only for the purpose of treating or preventing vitamin B12 deficiency, and the prescription must be endorsed ‘SLS (...) Oral vitamin B12 – what are the prescribing considerations and what formulations are available? Oral vitamin B12 – what are the prescribing considerations and what formulations are available? – SPS - Specialist Pharmacy Service – The first stop for professional medicines advice Menu · · Coronavirus (COVID-19) or . Use for the government response, and for health information. Published 29th June 2020 This Medicines Q&A outlines what oral vitamin B12 (cyanocobalamin) preparations are available

2020 Specialist Pharmacy Services

6. Injectable medicines commonly used in primary care during COVID-19: Vitamin B12

pandemic, options include: Replace IM hydroxocobalamin injection with cyanocobalamin tablets, 50–150 micrograms, daily between meals. The British Society for Haematology recommend reassessing serum B12 prior to recommencing IM hydroxocobalamin. Many of these patients may be vitamin B12 replete with adequate levels within the liver, and therefore may be able to safely stop taking vitamin B12 supplements possibly for up to a year Dietary advice should be given to all patients Patients on vegetarian (...) Injectable medicines commonly used in primary care during COVID-19: Vitamin B12 Injectable medicines commonly used in primary care during COVID-19: Vitamin B12 – SPS - Specialist Pharmacy Service – The first stop for professional medicines advice Menu · · Coronavirus (COVID-19) or . Use for the government response, and for health information. Published 13th May 2020 This page summarises the advice of the on the administration of hydroxocobalamin (vitamin B12) injections during COVID-19

2020 Specialist Pharmacy Services

7. Efficacy of Long-Term Oral Vitamin B12 Supplementation after Total Gastrectomy: Results from a Prospective Study Full Text available with Trip Pro

Efficacy of Long-Term Oral Vitamin B12 Supplementation after Total Gastrectomy: Results from a Prospective Study Vitamin B12 (VB12) deficiency is a common complication after total gastrectomy which may be associated with megaloblastic anemia and potentially irreversible neurologic symptoms. Intramuscular supplementation of VB12 has been considered the standard treatment, although it is associated with high costs and patient discomfort.We performed a prospective uncontrolled study (...) (ACTRN12614000107628) in order to evaluate the clinical and laboratory efficacy of long-term oral VB12 supplementation in patients submitted to total gastrectomy. All patients received daily oral VB12 (1 mg/day) and were evaluated every 3 months (clinical and laboratory evaluation: hemoglobin, VB12, total iron, ferritin, and folate).A total of 26 patients were included with a mean age of 64 years (29-79). Patients were included with a mean period of 65 months (3-309) after total gastrectomy. At inclusion time, 17

2017 GE Portuguese journal of gastroenterology

8. Vitamin E supplementation in people with cystic fibrosis. (Abstract)

Vitamin E supplementation in people with cystic fibrosis. People with cystic fibrosis are at an increased risk of fat-soluble vitamin deficiency, including vitamin E. Vitamin E deficiency can cause a host of conditions such as haemolytic anaemia, cerebellar ataxia and cognitive difficulties. Vitamin E supplementation is widely recommended for people with cystic fibrosis and aims to ameliorate this deficiency. This is an updated version of the review.To determine the effects of any level (...) of vitamin E supplementation on the frequency of vitamin E deficiency disorders in people with cystic fibrosis.We searched the Cochrane Group's Cystic Fibrosis Trials Register and also searched international online trial registries for any ongoing clinical trials that were not identified during our register search. Date of last search of the Register: 11 August 2020. Date of last search of international online trial registries: 20 July 2020.Randomised controlled trials and quasi-randomised controlled

2020 Cochrane

9. Vitamin D supplementation for sickle cell disease. (Abstract)

Vitamin D supplementation for sickle cell disease. Sickle cell disease (SCD) is a genetic chronic haemolytic and pro-inflammatory disorder. With increased catabolism and deficits in energy and nutrient intake, individuals with SCD suffer multiple macro- and micro-nutritional deficiencies, including vitamin D deficiency. This is an update of a previous review.To investigate the effects of vitamin D supplementation in children and adults with SCD and to compare different dose regimens (...) . To determine the effects of vitamin D supplementation on general health (e.g. growth status and health-related quality of life), on musculoskeletal health (including bone mineral density, pain crises, bone fracture and muscle health), on respiratory health (including lung function, acute chest syndrome, acute exacerbation of asthma and respiratory infections) and the safety of vitamin D supplementation.We searched the Cochrane Haemoglobinopathies Trials Register, compiled from electronic database searches

2020 Cochrane

10. Vitamin K supplementation for cystic fibrosis. Full Text available with Trip Pro

Vitamin K supplementation for cystic fibrosis. Malabsorption and deficiency of fat-soluble vitamins K may occur in cystic fibrosis, a genetic disorder affecting multiple organs. Vitamin K is known to play an important role in both blood coagulation and bone formation, hence the role of supplementation of vitamin K in this category needs to be reviewed. This is an updated version of the review.To assess the effects of vitamin K supplementation in people with cystic fibrosis and to investigate (...) journals and abstract books of conference proceedings. Most recent search: 12 August 2019.Randomised controlled trials of all preparations of vitamin K used as a supplement compared to either no supplementation (or placebo) at any dose or route and for any duration, in patients with cystic fibrosis.Two authors independently screened papers, extracted trial details and assessed their risk of bias. The quality of the evidence was assessed using the GRADE criteria.Three trials (total 70 participants, aged

2020 Cochrane

11. Vitamin C supplementation for prevention and treatment of pneumonia. (Abstract)

Vitamin C supplementation for prevention and treatment of pneumonia. According to the Global Burden of Disease Study 2015, lower respiratory tract infection is the leading cause of infectious disease death, and the fifth most common cause of death overall. Vitamin C has a role in modulating resistance to infectious agents, therefore vitamin C supplementation may be important in preventing and treating pneumonia.To assess the impact of vitamin C supplementation to prevent and treat pneumonia (...) in children and adults.We searched CENTRAL, MEDLINE, Embase, PubMed, CINAHL, LILACS, Web of Science, and two trials registers to 4 March 2020. We also checked references to identify additional studies. We did not apply any publication status or language filters.We included randomised controlled trials (RCTs) and quasi-RCTs (studies using allocation methods that are not random, e.g. date of birth, medical record number) assessing the role of vitamin C supplementation in the prevention and treatment

2020 Cochrane

12. Methylcobalamin Ultra (Vitamin B12) and Vitamin C Supplementation for the General Population: Clinical Evidence

Methylcobalamin Ultra (Vitamin B12) and Vitamin C Supplementation for the General Population: Clinical Evidence Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time (...) (Vitamin B12) and Vitamin C Supplementation for the General Population: Clinical Evidence DATE: 28 September 2012 RESEARCH QUESTIONS 1. What is the clinical evidence regarding the clinical benefit of Methylcobalamin Ultra (B12) supplementation in the general population? 2. What is the clinical evidence regarding the clinical benefit of Vitamin C supplementation in the general population? KEY MESSAGE Ten relevant systematic reviews and meta-analyses were identified regarding the clinical evidence

2012 Canadian Agency for Drugs and Technologies in Health - Rapid Review

13. Impact of baseline vitamin B12 status on the effect of vitamin B12 supplementation on neurologic function in older people: secondary analysis of data from the OPEN randomised controlled trial. Full Text available with Trip Pro

Impact of baseline vitamin B12 status on the effect of vitamin B12 supplementation on neurologic function in older people: secondary analysis of data from the OPEN randomised controlled trial. The available evidence from randomised controlled trials suggests that vitamin B12 supplementation does not improve neurologic function in older people with marginal but not deficient Vitamin B12 status. This secondary analysis used data from the Older People and Enhanced Neurological function (OPEN (...) ) randomised controlled trial to assess whether baseline vitamin B12 status or change in vitamin B12 status over 12 months altered the effectiveness of dietary vitamin B12 supplementation on neurologic function in asymptomatic older people with depleted vitamin B12 status at study entry.Vitamin B12 status was measured as serum concentrations of vitamin B12, holotranscobalamin, homocysteine and via a composite indicator (cB12). Neurological function outcomes included eleven electrophysiological measures

2017 European journal of clinical nutrition Controlled trial quality: uncertain

14. Effect of 8-week oral supplementation with 3-µg cyano-B12 or hydroxo-B12 in a vitamin B12-deficient population. Full Text available with Trip Pro

Effect of 8-week oral supplementation with 3-µg cyano-B12 or hydroxo-B12 in a vitamin B12-deficient population. We compare the effect of 8-week oral supplementation with cyano-B12 (currently used in vitamin pills) and hydroxo-B12 (predominant form in the diet) in a population with nutritional vitamin B12 deficiency.Fifty-one healthy Indian adults with baseline serum cobalamin < 200 pmol/L were supplied for 8 weeks with daily oral supplements of 3-µg cyano-B12 (n = 15), 3-µg hydroxo-B12 (n = 16 (...) with cyano-B12 showed a higher increase in total serum cobalamin than the group treated with hydroxo-B12, while other biomarkers changed comparably in the two groups. After 8 weeks of treatment, the biomarker values of the supplemented groups (pooled) differed significantly from the placebo group. Yet, the vitamin B12 status was still poor [cobalamin: 168 (87-302) pmol/L; holotranscobalamin: 19 (8-45) pmol/L; methylmalonic acid: 0.7 (0.2-1.7) µmol/L; homocysteine: 17.2 (2.6-96.8) µmol/L; 4cB12 = - 1.34

2017 European journal of nutrition

15. Folic acid and vitamin-B12 supplementation and the risk of cancer: long-term follow-up of the B-vitamins for the Prevention Of Osteoporotic Fractures (B-PROOF) trial. Full Text available with Trip Pro

Folic acid and vitamin-B12 supplementation and the risk of cancer: long-term follow-up of the B-vitamins for the Prevention Of Osteoporotic Fractures (B-PROOF) trial. Folic acid and vitamin B12 play key roles in one-carbon metabolism. Disruption of one-carbon metabolism may be involved in the risk of cancer. Our aim was to assess the long-term effect of supplementation with both folic acid and vitamin B12 on the incidence of overall cancer and on colorectal cancer in the B Vitamins (...) for the Prevention of Osteoporotic Fractures (B-PROOF) trial.Long-term follow-up of B-PROOF trial participants (N = 2,524), a multicenter, double-blind randomized placebo-controlled trial designed to assess the effect of 2 to 3 years daily supplementation with folic acid (400 μg) and vitamin B12 (500 μg) versus placebo on fracture incidence. Information on cancer incidence was obtained from the Netherlands cancer registry (Integraal Kankercentrum Nederland), using the International Statistical Classification

2018 Cancer Epidemiology & Biomarkers and Prevention Controlled trial quality: predicted high

16. Timing of folic acid/vitamin B12 supplementation and hematologic toxicity during first-line treatment of patients with nonsquamous non-small cell lung cancer using pemetrexed-based chemotherapy: The PEMVITASTART randomized trial. (Abstract)

Timing of folic acid/vitamin B12 supplementation and hematologic toxicity during first-line treatment of patients with nonsquamous non-small cell lung cancer using pemetrexed-based chemotherapy: The PEMVITASTART randomized trial. Vitamin B12 and folic acid (FA) supplementation (B12-FAS) reduces hematologic toxicity with pemetrexed-based chemotherapy (PEM). However, the basis for recommending 1 week of B12-FAS before PEM initiation has never been proven in a randomized trial.An open-label (...) the curve = 5.0 mg/mL per minute) on day 1 for a maximum of 6 cycles. Supplementation consisted of oral FA 1000 μg daily and intramuscular vitamin B12 1000 μg every 3 weeks. The primary outcome was any grade of hematologic toxicity and secondary outcomes included grade 3/4 hematologic toxicity, the relative dose intensity delivered, and changes in serum levels of B12/FA/homocysteine.Of 161 patients (IA, n = 81; DA, n = 80) recruited, 150 (IA, n = 77; DA, n = 73) received ≥1 cycle and were included

2019 Cancer Controlled trial quality: predicted high

17. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis. Full Text available with Trip Pro

The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis. Plasma homocysteine level and megaloblastic anemia status are two factors that can affect the quality of life of patients with multiple sclerosis (MS). We conducted this study to determine the effect of vitamin B12 and folic acid supplementation on serum homocysteine, megaloblastic anemia status and quality of life of patients with MS. A total (...) physical and mental fields of quality of life were improved significantly in the vitamin group (40.38 ± 15.07 to 59.21 ± 12.32 and 29.58 ± 15.99 to 51.68 ± 18.22, respectively; p = 0.001). Serum homocysteine level decrease and anemia status improvement with vitamin B12 and folic acid supplementation reveal the potential role of these two vitamins in improving the life quality of MS patients.Iranian Registry of Clinical Trials Identifier: IRCT2015100313678N7.

2019 Clinical nutrition research Controlled trial quality: uncertain

18. Regimens of vitamin D supplementation for women during pregnancy. Full Text available with Trip Pro

Regimens of vitamin D supplementation for women during pregnancy. Vitamin D deficiency during pregnancy increases the risk of pre-eclampsia, gestational diabetes, preterm birth, and low birthweight. In a previous Cochrane Review we found that supplementing pregnant women with vitamin D alone compared to no vitamin D supplementation may reduce the risk of pre-eclampsia, gestational diabetes, and low birthweight and may increase the risk of preterm births if it is combined with calcium. However (...) the effects of different vitamin D regimens are not yet clear.To assess the effects and safety of different regimens of vitamin D supplementation alone or in combination with calcium or other vitamins, minerals or nutrients during pregnancy, specifically doses of 601 international units per day (IU/d) or more versus 600 IU/d or less; and 4000 IU/d or more versus 3999 IU/d or less.We searched the Cochrane Pregnancy and Childbirth's Trials Register, ClinicalTrials.gov, the WHO International Clinical Trials

2019 Cochrane

19. Vitamin D supplementation for women during pregnancy. Full Text available with Trip Pro

Vitamin D supplementation for women during pregnancy. Vitamin D supplementation during pregnancy may be needed to protect against adverse pregnancy outcomes. This is an update of a review that was first published in 2012 and then in 2016.To examine whether vitamin D supplementation alone or in combination with calcium or other vitamins and minerals given to women during pregnancy can safely improve maternal and neonatal outcomes.For this update, we searched Cochrane Pregnancy and Childbirth's (...) Trials Register (12 July 2018), contacted relevant organisations (15 May 2018), reference lists of retrieved trials and registries at clinicaltrials.gov and WHO International Clinical Trials Registry Platform (12 July 2018). Abstracts were included if they had enough information to extract the data.Randomised and quasi-randomised trials evaluating the effect of supplementation with vitamin D alone or in combination with other micronutrients for women during pregnancy in comparison to placebo

2019 Cochrane Controlled trial quality: predicted high

20. Vitamin B12 intramuscular injections versus oral supplements: a budget impact analysis

Vitamin B12 intramuscular injections versus oral supplements: a budget impact analysis Vitamin B12 intramuscular injections versus oral supplements: a budget impact analysis Vitamin B12 intramuscular injections versus oral supplements: a budget impact analysis Masucci L, Goeree R Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Masucci L (...) , Goeree R. Vitamin B12 intramuscular injections versus oral supplements: a budget impact analysis. Toronto: Health Quality Ontario (HQO). Ontario Health Technology Assessment Series (OHTAS) 13(24). 2013 Authors' conclusions Over 5 years, there are savings of $14.2 million to the health care system from switching to vitamin B12 oral supplements. Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Administration, Oral; Dietary Supplements Costs; Injections, Intramuscular; Vitamin

2014 Health Technology Assessment (HTA) Database.

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