How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

17,242 results for

Vitamin B12 Deficiency

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

161. An assessment of the risk factors for vitamin D deficiency using a decision tree model. (Abstract)

An assessment of the risk factors for vitamin D deficiency using a decision tree model. Vitamin D (25-hydroxyvitamin D or 25OHD) has a key role in the pathogenesis of several chronic disorders. Vitamin D deficiency is a common global public health problem. We aimed to evaluate the risk factors associated with vitamin D deficiency using a decision tree algorithm.A total of 988 adolescent girls, aged 12-18 years old, were recruited to the study. Demographic characteristics, serum biochemical (...) factors, all blood count parameters and trace elements such as Zinc, Copper, Calcium and SOD were measured. Serum levels of vitamin D below 20 ng/ml were considered to be deficiency. 70% of these girls (618 cases) were randomly allocated to a training dataset for the constructing of the decision-tree. The remaining 30% (285 cases) were used as the testing dataset to evaluate the performance of decision-tree. In this model, 14 input variables were included: age, academic attainment of their father

2019 Diabetes & metabolic syndrome Controlled trial quality: uncertain

162. Safety and effectiveness of stoss therapy in children with vitamin D deficiency. (Abstract)

Safety and effectiveness of stoss therapy in children with vitamin D deficiency. Paediatric vitamin D (25-hydroxyvitamin D (25OHD)) deficiency can lead to nutritional rickets and extra-skeletal complications. Compliance with daily therapy can be difficult, making high-dose, short-term vitamin D (stoss) therapy attractive to correct vitamin D deficiency. We compared the effectiveness and safety of standard versus stoss therapy in treating childhood 25OHD deficiency.Children aged 2-16 years (...) , in both groups, there was a similar proportion of participants who achieved 25OHD sufficiency, with no evidence of toxicity. Unlike other studies, simplifying the treatment regimen did not improve compliance. These results support stoss therapy as an effective and safe alternative therapy for the treatment of paediatric vitamin D deficiency.© 2019 Paediatrics and Child Health Division (The Royal Australasian College of Physicians).

2019 Journal of paediatrics and child health Controlled trial quality: uncertain

163. Invited commentary in response to "Vitamin D3 supplementation for 8 weeks leads to improved haematological status following the consumption of an iron-fortified breakfast cereal: a double-blind randomised controlled trial in iron-deficient women." (Abstract)

Invited commentary in response to "Vitamin D3 supplementation for 8 weeks leads to improved haematological status following the consumption of an iron-fortified breakfast cereal: a double-blind randomised controlled trial in iron-deficient women." 31280725 2019 07 08 1475-2662 2019 Jul 08 The British journal of nutrition Br. J. Nutr. Invited commentary in response to "Vitamin D3 supplementation for 8 weeks leads to improved haematological status following the consumption of an iron-fortified (...) breakfast cereal: a double-blind randomised controlled trial in iron-deficient women." 1-4 10.1017/S0007114519001569 Blanco-Rojo Ruth R Research Department, Biosearch Life,Granada(Spain). eng Journal Article 2019 07 08 England Br J Nutr 0372547 0007-1145 2019 7 9 6 0 2019 7 10 6 0 2019 7 10 6 0 aheadofprint 31280725 S0007114519001569 10.1017/S0007114519001569

2019 The British journal of nutrition Controlled trial quality: predicted high

164. VITAMIN D DEFICIENCY IN ADULTS: SEARCHING FOR THE PROPER LOADING DOSE. (Abstract)

VITAMIN D DEFICIENCY IN ADULTS: SEARCHING FOR THE PROPER LOADING DOSE. Vitamin D is the main hormone regulating calcium phosphate homeostasis and mineral bone metabolism. Vitamin D deficiency is indeed extremely frequent in musculoskeletal diseases. Recent studies have shown that the treatment of osteoporosis needs to have an optimal vitamin D and calcium supplementation for its efficacy. Actually no agreement exists on the estabilished dose of vitamin D to administer in deficency states. We (...) conducted a prospective study to develop a practical cholecalciferol loading dose regimen that would enable rapid correction of vitamin D deficiency. Sixty post-menopausal age woman were enrolled secondary to a fragility fracture (hip, vertebral, wrist) and screened for 25-hydroxyvitamin D (25(OH)D), calcium, and PTH at baseline (T0), after one month (T1), two months (T2), three months (T3) and six months (T4). Secondary to initial blood values of vitamin D patients were divided into 2 groups; the first

2019 Journal of biological regulators and homeostatic agents Controlled trial quality: uncertain

165. Vitamin D Deficiency Is Associated with Muscle Atrophy and Reduced Mitochondrial Function in Patients with Chronic Low Back Pain. Full Text available with Trip Pro

Vitamin D Deficiency Is Associated with Muscle Atrophy and Reduced Mitochondrial Function in Patients with Chronic Low Back Pain. Recent studies show that vitamin D deficiency may be responsible for muscle atrophy. The purpose of this study was to investigate markers of muscle atrophy, signalling proteins, and mitochondrial capacity in patients with chronic low back pain with a focus on gender and serum vitamin D level. The study involved patients with chronic low back pain (LBP) qualified (...) for posterior lumbar interbody fusion (PLIF). Patients were divided into three groups: supplemented (SUPL) with vitamin D (3200 IU/day for 5 weeks), placebo with normal levels of vitamin D (SUF), and the placebo group with vitamin D deficiency (DEF). The marker of muscle atrophy including atrogin-1 and protein content for IGF-1, Akt, FOXO3a, PGC-1α, and citrate synthase (CS) activity were determined in collected multifidus muscle. In the paraspinal muscle, IGF-1 levels were higher in the SUF group

2019 Oxidative medicine and cellular longevity Controlled trial quality: uncertain

166. Vitamin D3 supplementation for 8 weeks leads to improved haematological status following the consumption of an iron-fortified breakfast cereal: a double-blind randomised controlled trial in iron-deficient women. Full Text available with Trip Pro

Vitamin D3 supplementation for 8 weeks leads to improved haematological status following the consumption of an iron-fortified breakfast cereal: a double-blind randomised controlled trial in iron-deficient women. The effect of 38 µg (1500 IU) daily vitamin D3 supplementation, consumed with an Fe-fortified breakfast cereal for 8 weeks, on haematological indicators in Fe-deficient female subjects was investigated. Fifty Fe-deficient subjects (plasma ferritin concentration <20 µg/l; mean age: 27 (...) 4·3) to 40·7 (sd 3·6) %) (P=0·032). Despite the non-significant changes in plasma ferritin concentration, this study demonstrates that 38 µg supplemental vitamin D, consumed daily, with Fe-fortified breakfast cereal led to improvement in Hb concentration and haematocrit levels in women with low Fe stores. These findings may have therapeutic implications in the recovery of Fe status in Fe-deficient populations at a healthcare level.

2019 The British journal of nutrition Controlled trial quality: predicted high

167. Vitamin D Deficiency in Patients With Idiopathic and Traumatic Osteochondritis Dissecans of the Talus. (Abstract)

Vitamin D Deficiency in Patients With Idiopathic and Traumatic Osteochondritis Dissecans of the Talus. Low vitamin D levels are common in patients with foot and ankle disorders. We have previously demonstrated that juveniles diagnosed with osteochondritis dissecans (OCD) have a high prevalence of vitamin D deficiency. Moreover, there is evidence that OCD might be related to vitamin D deficiency in general. However, whether or not hypovitaminosis D is associated with OCD of the talus has yet (...) to be elucidated.The aim of this study was to determine serum vitamin D levels [25(OH)D] of patients diagnosed with traumatic and idiopathic OCD of the talus. The vitamin D status of patients was measured and correlated to age, sex, season, etiology, laterality, degree of disease, and nicotine abuse. Moreover, parathyroid hormone and serum calcium levels of patients were obtained to assess for severe vitamin D deficiency and secondary hyperparathyroidism. Between January 2015 and December 2017, 65 patients

2019 Foot & Ankle International

168. Newborn Screening for Vitamin B<sub>12</sub> Deficiency in Germany-Strategies, Results, and Public Health Implications. (Abstract)

Newborn Screening for Vitamin B12 Deficiency in Germany-Strategies, Results, and Public Health Implications. To evaluate a systematic newborn screening (NBS) strategy for vitamin B12 deficiency.In a prospective single-center NBS study, a systematic screening strategy for vitamin B12 deficiency was developed and evaluated. Tandem-mass spectrometry screening was complemented by 2 second-tier strategies, measuring methylmalonic/3-OH-propionic/methylcitric acid, and homocysteine from (...) dried blood spots.In a cohort of 176 702 children screened over 27 months, 33 children were detected by NBS in whom (maternal) vitamin B12 deficiency was confirmed. Homocysteine was the most sensitive marker for vitamin B12 deficiency, but only combination with a second-tier strategy evaluating methylmalonic acid allowed for detection of all 33 children. Mothers were of various ethnic origins, and 89% adhered to a balanced diet. Treatment in children was performed predominantly by oral vitamin B12

2019 Journal of Pediatrics

169. Relative Contributions of Malaria, Inflammation, and Deficiencies of Iron and Vitamin A to the Burden of Anemia during Low and High Malaria Seasons in Rural Zambian Children. (Abstract)

Relative Contributions of Malaria, Inflammation, and Deficiencies of Iron and Vitamin A to the Burden of Anemia during Low and High Malaria Seasons in Rural Zambian Children. To estimate the burden of anemia attributable to malaria, inflammation, and deficiency of iron or vitamin A during low and high malaria seasons among Zambian children.From a cohort of children (n = 820), 4-8 years of age participating in a randomized controlled trial of pro-vitamin A, we estimated attributable fractions (...) for anemia (hemoglobin of <110 or 115 g/L, by age) owing to current malaria or inflammation (C-reactive protein of >5 mg/L, or α-1 acid glycoprotein of >1 g/L, or both), and current or prior iron deficiency (ID; defined as low ferritin [<12 or 15 μg/L for age <5 or >5 years] or functional ID [soluble transferrin receptor of >8.3 mg/L] or both) and vitamin A deficiency (retinol of <0.7 μmol/L), during low and high malaria seasons, using multivariate logistic regression. Serum ferritin, soluble transferrin

2019 Journal of Pediatrics Controlled trial quality: uncertain

170. Impact of Vitamin D Supplementation on Influenza Vaccine Response and Immune Functions in Deficient Elderly Persons: A Randomized Placebo-Controlled Trial. Full Text available with Trip Pro

Impact of Vitamin D Supplementation on Influenza Vaccine Response and Immune Functions in Deficient Elderly Persons: A Randomized Placebo-Controlled Trial. Background: Immunosenescence contributes to reduced vaccine response in elderly persons, and is worsened by deficiencies in nutrients such as Vitamin (Vit-D). The immune system is a well-known target of Vit-D, which can both potentiate the innate immune response and inhibit the adaptive system, and so modulate vaccination response. Objective (...) : This randomized placebo-controlled double-blind trial investigated whether Vit-D supplementation in deficient elderly persons could improve influenza seroprotection and immune response. Design: Deficient volunteers (Vit-D serum <30 ng/mL) were assigned (V1) to receive either 100,000 IU/15 days of cholecalciferol (D, n = 19), or a placebo (P, n = 19), over a 3 month period. Influenza vaccination was performed at the end of this period (V2), and the vaccine response was evaluated 28 days later (V3). At each

2019 Frontiers in immunology Controlled trial quality: predicted high

171. Response to Letter to the Editor: "Effectiveness of Prenatal Vitamin D Deficiency Screening and Treatment Program: A Stratified Randomized Field Trial". Full Text available with Trip Pro

Response to Letter to the Editor: "Effectiveness of Prenatal Vitamin D Deficiency Screening and Treatment Program: A Stratified Randomized Field Trial". 30202978 2018 12 19 1945-7197 104 2 2019 Feb 01 The Journal of clinical endocrinology and metabolism J. Clin. Endocrinol. Metab. Response to Letter to the Editor: "Effectiveness of Prenatal Vitamin D Deficiency Screening and Treatment Program: A Stratified Randomized Field Trial". 339-340 10.1210/jc.2018-01799 Ramezani Tehrani Fahimeh F

2019 The Journal of clinical endocrinology and metabolism Controlled trial quality: uncertain

172. Randomized trial of three doses of vitamin D to reduce deficiency in pregnant Mongolian women. Full Text available with Trip Pro

Randomized trial of three doses of vitamin D to reduce deficiency in pregnant Mongolian women. In winter in Mongolia, 80% of adults have 25-hydroxyvitamin D (25(OH)D) concentrations <25 nmol/l (<10 ng/ml) and 99% have <50 nmol/l (<20 ng/ml). The vitamin D dose to avert deficiency during pregnancy in this population is unknown.We conducted a randomized, controlled, double-blind trial of daily 600, 2000, or 4000 IU vitamin D3 for pregnant women in Mongolia (Clinicaltrials.gov #NCT02395081). We (...) . There were no adverse events, including hypercalcemia, attributable to vitamin D supplementation.Daily supplementation of 4000 IU during pregnancy is safe and achieved higher maternal and neonatal 25(OH)D concentrations than 2000 IU. Daily 600 IU supplements are insufficient to prevent vitamin D deficiency in Mongolia. FUND: Anonymous foundation and Brigham and Women's Hospital.Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

2019 EBioMedicine Controlled trial quality: predicted high

173. Vitamin D deficiency and mild to moderate anemia in young North Indian children: A secondary data analysis. (Abstract)

Vitamin D deficiency and mild to moderate anemia in young North Indian children: A secondary data analysis. The aim of this study was to examine the association between vitamin D deficiency and anemia status among young children in the resource-poor setting of northern urban India.We used data from a randomized controlled trial of daily supplementation with folic acid, vitamin B12, or both for 6 mo in children 6 to 30 mo of age conducted in Delhi, India. We measured serum vitamin D status (...) , hemoglobin, plasma vitamin B12, folate, soluble transferrin receptor, and homocysteine levels at baseline. Children with severe anemia (hemoglobin [Hgb] <7 g/dL) were excluded from enrollment. Multivariable logistic and multinomial logistic regressions were used to examine the association between vitamin D and anemia status at baseline.25-Hydroxyvitamin-D (25 OHD) concentration was measured for 960 (96%) children. Of the children, 331 (34.5%) were vitamin-D deficient (<10 ng/mL). Approximately 70

2019 Nutrition (Burbank, Los Angeles County, Calif.) Controlled trial quality: predicted high

174. Letter to the Editor: "Effectiveness of Prenatal Vitamin D Deficiency Screening and Treatment Program: A Stratified Randomized Field Trial". Full Text available with Trip Pro

Letter to the Editor: "Effectiveness of Prenatal Vitamin D Deficiency Screening and Treatment Program: A Stratified Randomized Field Trial". 30202903 2018 12 19 1945-7197 104 2 2019 Feb 01 The Journal of clinical endocrinology and metabolism J. Clin. Endocrinol. Metab. Letter to the Editor: "Effectiveness of Prenatal Vitamin D Deficiency Screening and Treatment Program: A Stratified Randomized Field Trial". 337-338 10.1210/jc.2018-01731 Shub Alexis A Department of Obstetrics and Gynecology

2019 The Journal of clinical endocrinology and metabolism Controlled trial quality: uncertain

175. Association of Maternal Vitamin D Deficiency with Early Childhood Caries. (Abstract)

Association of Maternal Vitamin D Deficiency with Early Childhood Caries. Alaska Native (AN) children experience one of the highest reported rates of severe early childhood caries (S-ECC). Serum vitamin D concentrations in AN childbearing women in the Yukon Kuskokwim Delta (YKD) region have decreased since the 1960s to currently low levels, related to a decrease in traditional marine diet. Recent studies suggest an association between prenatal vitamin D (25(OH)D) concentrations in mothers and S (...) had "sufficient" versus "insufficient" 25(OH)D during prenatal visits (9.0 vs. 7.4; P = 0.48). In this small sample, children with deficient vitamin D levels in cord blood had a dmft score at 12 to 35 mo 2-fold higher than children with nondeficient cord blood. Maternal 25(OH)D may influence the primary dentition, and improving vitamin D status in pregnant women might affect ECC rates in their infants.

2019 Journal of Dental Research

176. Vitamin D deficiency in children: a challenging diagnosis! (Abstract)

Vitamin D deficiency in children: a challenging diagnosis! The concern about the assessment of vitamin D status is growing. Numerous publications warn about the high prevalence of vitamin D deficiency, as well as the potential role of vitamin D in non-bone health outcomes. The status of vitamin D is usually assessed by measuring serum total 25-hydroxyvitamin D (25OHD) concentration. This is the major circulating form of vitamin D and keeps an inverse correlation with serum parathyroid hormone (...) (PTH) concentration. A value of 25OHD of 20 ng/ml is generally assumed as threshold of vitamin D sufficiency in epidemiologic studies because serum PTH tends to increase when the 25OHD concentration stands below this value. In pediatric population, very few studies have analyzed this issue and the negative relationship between serum 25OHD and serum PTH is not clear, which is the suitable circulating concentration of 25OHD and the threshold of deficiency being matters of controversy. The majority

2019 Pediatric Research

177. Associated vitamin D deficiency is a risk factor for the complication of HCV-related liver cirrhosis including hepatic encephalopathy and spontaneous bacterial peritonitis. (Abstract)

Associated vitamin D deficiency is a risk factor for the complication of HCV-related liver cirrhosis including hepatic encephalopathy and spontaneous bacterial peritonitis. The influence of vitamin D, 25-hydroxyvitamin D (25(OH)D), deficiency on hepatitis C virus (HCV)-related cirrhosis had been poorly elucidated especially in patients with hepatic encephalopathy (HE) and spontaneous bacterial peritonitis (SBP). We aimed to investigate the association between vitamin D deficiency and the risk (...) of SBP or HE, including the mortality rate. Serum 25(OH)D levels were prospectively determined in 135 patients. Of them, 45 patients had complications with HE and 45 patients had complications with SBP; 45 cirrhotic patients without complication served as the control group. Vitamin D deficiency was defined as 25(OH)D levels < 20 ng/ml. Receiver operating characteristic (ROC) and Kaplan-Meier method with log-rank test were used in our statistical analysis. Predictors of survival were determined using

2019 Internal and emergency medicine

178. Vitamin D deficiency and health-related quality of life in chronic hepatitis C. Full Text available with Trip Pro

Vitamin D deficiency and health-related quality of life in chronic hepatitis C. 30739371 2019 03 05 1365-2893 2019 Feb 09 Journal of viral hepatitis J. Viral Hepat. Vitamin D deficiency and health-related quality of life in chronic hepatitis C. 10.1111/jvh.13076 Palazzo Donatella D Hepatology Unit, Department of Clinical Medicine, Sapienza University of Rome, Rome, Italy. Biliotti Elisa E https://orcid.org/0000-0002-4540-1815 Hepatology Unit, Department of Clinical Medicine, Sapienza University (...) , Rome, Italy. eng Journal Article 2019 02 09 England J Viral Hepat 9435672 1352-0504 : chronic hepatitis C health survey short form-36 health-related quality of life vitamin D 2018 07 19 2019 01 11 2019 2 11 6 0 2019 2 11 6 0 2019 2 11 6 0 aheadofprint 30739371 10.1111/jvh.13076

2019 Journal of viral hepatitis

179. Vitamin B <sub><sub>12</sub></sub> deficiency and hyperhomocysteinaemia in outpatients with stroke or transient ischaemic attack: a cohort study at an academic medical centre. Full Text available with Trip Pro

Vitamin B 12 deficiency and hyperhomocysteinaemia in outpatients with stroke or transient ischaemic attack: a cohort study at an academic medical centre. We sought to assess the current magnitude of the opportunity for secondary stroke prevention with B vitamins.A cohort study.The Urgent TIA (Transient Ischaemic Attack) Clinic at an academic medical centre.We assessed the prevalence of biochemical vitamin B12 deficiency (B12Def, serum B12 <156 pmol/L (...) ), hyperhomocysteinaemia (HHcy; plasma total homocysteine [tHcy] >14 µmol/L) and metabolic B12 deficiency (MetB12Def, serum B12 <258 pmol/L and HHcy) between 2002 and 2017, by age group and by stroke subtype.Data were available in 4055 patients. B12Def was present in 8.2% of patients overall; it declined from 10.9% of patients referred before 2009 to 5.4% thereafter (p=0.0001). MetB12Def was present in 10.6% of patients, and HHcy was present in 19.1% of patients. Among the patients aged ≥80 years, MetB12Def

2019 BMJ open

180. Rapid vs Maintenance Vitamin D Supplementation in Deficient Children With Asthma to Prevent Exacerbations (Abstract)

Rapid vs Maintenance Vitamin D Supplementation in Deficient Children With Asthma to Prevent Exacerbations Whether vitamin D reduces clinically important exacerbations of childhood asthma remains uncertain. We compared rapid to maintenance vitamin D repletion analyzed by baseline vitamin D level.Children presenting to the ED with moderate-to-severe asthma exacerbations and vitamin D levels ≤ 25 ng/mL underwent masked randomization, and then open dosing to either IM+oral (the latter daily (...) ) therapy or daily oral-only therapy, and were followed for 12 months. The primary outcome was patient-initiated unplanned visits for asthma exacerbations, examined two ways: cumulative proportions with an exacerbation, and average exacerbation frequency. As this was a nutrient study, we analyzed treatment groups by quartile of baseline vitamin D level, collecting repeat levels and clinical observations at 3, 6, 9, and 12 months after enrollment.One hundred and sixteen patients in the IM+oral cohort vs

2017 EvidenceUpdates

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>