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Vitamin B12 Deficiency

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16641. Conjunctival impression cytology for vitamin A deficiency in the presence of infectious trachoma (PubMed)

Conjunctival impression cytology for vitamin A deficiency in the presence of infectious trachoma Increased morbidity and mortality from a number of infectious diseases have been associated with vitamin A deficiency. Trachoma and vitamin A deficiency are both important causes of blindness in Nepal. The purpose of this study was to determine the association between the diagnosis of vitamin A deficiency by conjunctival impression cytology and the diagnosis of infectious trachoma by the polymerase (...) chain reaction (PCR) in the Lumbini zone of Nepal.70 children under the age of 11 in a rural village in the Lumbini zone were examined for clinical evidence of active trachoma. The conjunctiva of each child was tested for ocular Chlamydia trachomatis infection using PCR, and for loss of goblet cells (a sign of subclinical vitamin A deficiency) using conjunctival impression cytology.The presence of infectious trachoma was associated with the loss of goblet cells on conjunctival impression cytology (p

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1998 The British journal of ophthalmology

16642. Vitamin D deficiency: time for action : Evidence supports routine supplementation for elderly people and others at risk  (PubMed)

Vitamin D deficiency: time for action : Evidence supports routine supplementation for elderly people and others at risk  9831568 1999 01 07 2018 11 13 0959-8138 317 7171 1998 Nov 28 BMJ (Clinical research ed.) BMJ Vitamin D deficiency: time for action. Evidence supports routine supplementation for elderly people and others at risk. 1466-7 Compston J E JE eng Editorial England BMJ 8900488 0959-8138 1406-16-2 Vitamin D AIM IM BMJ. 1999 May 8;318(7193):1284-5; author reply 1285 10391703 BMJ (...) . 1999 May 8;318(7193):1284; author reply 1285 10231270 BMJ. 1999 May 8;318(7193):1285 10391704 Aged Humans Middle Aged Risk Factors Vitamin D administration & dosage Vitamin D Deficiency complications therapy 1998 11 30 1998 11 30 0 1 1998 11 30 0 0 ppublish 9831568 PMC1114332 Am J Clin Nutr. 1994 Oct;60(4):619-30 8092101 BMJ. 1994 Apr 23;308(6936):1081-2 8173430 Ann Intern Med. 1996 Feb 15;124(4):400-6 8554248 N Engl J Med. 1997 Sep 4;337(10):670-6 9278463 Am J Clin Nutr. 1997 Oct;66(4):929-36

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1998 BMJ : British Medical Journal

16643. Genetics of vitamin D 1alpha-hydroxylase deficiency in 17 families. (PubMed)

Genetics of vitamin D 1alpha-hydroxylase deficiency in 17 families. Vitamin D-dependent rickets type I (VDDR-I), also known as pseudo-vitamin D-deficiency rickets, appears to result from deficiency of renal vitamin D 1alpha-hydroxylase activity. Prior work has shown that the affected gene lies on 12q13.3. We recently cloned the cDNA and gene for this enzyme, mitochondrial P450c1alpha, and we and others have found mutations in its gene in a few patients. To determine whether all patients (...) replacement mutations. When these missense mutations were analyzed by expressing the mutant enzyme in mouse Leydig MA-10 cells and assaying 1alpha-hydroxylase activity, none retained detectable 1alpha-hydroxylase activity. These studies show that most if not all patients with VDDR-I have severe mutations in P450c1alpha, and hence the disease should be referred to as "1alpha-hydroxylase deficiency."

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1998 American Journal of Human Genetics

16644. Vitamin A deficiency in coeliac disease (PubMed)

Vitamin A deficiency in coeliac disease 11032445 2000 10 10 2008 11 20 0007-1161 84 9 2000 Sep The British journal of ophthalmology Br J Ophthalmol Vitamin A deficiency in coeliac disease. 1079-80 Alwitry A A eng Case Reports Letter England Br J Ophthalmol 0421041 0007-1161 11103-57-4 Vitamin A IM Celiac Disease complications Corneal Diseases etiology Humans Injections, Intramuscular Male Middle Aged Visual Acuity physiology Vitamin A administration & dosage Vitamin A Deficiency etiology 2000

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2000 The British journal of ophthalmology

16645. Bitot's spots and vitamin A deficiency in a child from the UK (PubMed)

Bitot's spots and vitamin A deficiency in a child from the UK 11277102 2001 04 05 2008 11 20 0007-1161 85 3 2001 Mar The British journal of ophthalmology Br J Ophthalmol Bitot's spots and vitamin A deficiency in a child from the UK. 372 Ramsay A A Sabrosa N A NA Pavesio C E CE eng Case Reports Letter England Br J Ophthalmol 0421041 0007-1161 IM Child Diet, Vegetarian adverse effects Female Humans Vitamin A Deficiency etiology Xerophthalmia etiology 2001 3 30 10 0 2001 4 6 10 1 2001 3 30 10 0

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2001 The British journal of ophthalmology

16646. Prophylaxis of neonatal vitamin K deficiency bleeding in premature infants (PubMed)

Prophylaxis of neonatal vitamin K deficiency bleeding in premature infants 11351987 2001 05 24 2008 11 20 1359-2998 84 3 2001 May Archives of disease in childhood. Fetal and neonatal edition Arch. Dis. Child. Fetal Neonatal Ed. Prophylaxis of neonatal vitamin K deficiency bleeding in premature infants. F218 Josty T L TL Matthes J W JW eng Letter England Arch Dis Child Fetal Neonatal Ed 9501297 1359-2998 12001-79-5 Vitamin K AIM IM Government Publications as Topic Guideline Adherence Humans (...) Infant, Newborn Infant, Premature Practice Guidelines as Topic Vitamin K administration & dosage Vitamin K Deficiency drug therapy 2001 5 16 10 0 2001 5 26 10 1 2001 5 16 10 0 ppublish 11351987 PMC1721239

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2001 Archives of Disease in Childhood. Fetal and Neonatal Edition

16647. Sensitivity of respiratory chain activities to lipid peroxidation: effect of vitamin E deficiency. (PubMed)

Sensitivity of respiratory chain activities to lipid peroxidation: effect of vitamin E deficiency. Rats fed a vitamin E-depleted diet for 48 weeks had undetectable levels of vitamin E in the gastrocnemius muscle and liver, leading to elevated malondialdehyde levels in both tissues and an elevated GSH level in muscle. Skeletal-muscle mitochondria showed decreased mitochondrial respiratory chain (MRC) activities, whereas liver MRC activities were increased. Exposure of normal rat liver (...) submitochondrial particles (SMPs) to an in vitro NADPH-dependent lipid peroxidation system resulted in a dose-dependent increase in lipid peroxidation and inhibition of complex I and complex IV activities. Complex I exhibited greater sensitivity to lipid peroxidation than complex IV. At low and high NADPH concentrations, the rate of lipid peroxidation and the level of enzyme inhibition were essentially the same in liver SMPs from both vitamin E-deficient and control rats, suggesting that under these conditions

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2001 Biochemical Journal

16648. Vitamin D deficiency in UK Asian families: activating a new concern (PubMed)

Vitamin D deficiency in UK Asian families: activating a new concern Vitamin D has steroid hormonal effects which can produce clinical symptoms and signs unrelated to calcium homoeostasis. Its deficiency has been implicated as a risk factor for diabetes, ischaemic heart disease, and tuberculosis in Asians. In this review, the incidence, aetiology, prevention, and treatment of symptomatic vitamin D deficiency in childhood are considered. A renewed public health campaign is required in the UK (...) to address the continuing problem of vitamin D deficiency in Asian families.

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2002 Archives of Disease in Childhood

16649. Vitamin D Deficiency and Secondary Hyperparathyroidism Are Common Complications in Patients with Peripheral Arterial Disease (PubMed)

Vitamin D Deficiency and Secondary Hyperparathyroidism Are Common Complications in Patients with Peripheral Arterial Disease To investigate via the vitamin D status whether patients with peripheral arterial disease (PAD) tend to develop vitamin D deficiency that in turn influences their clinical symptoms.Cross-sectional.University hospital.Three hundred twenty-seven patients were evaluated; subjects with secondary causes of bone disease or bone active medication were excluded. One hundred sixty (...) with PAD IV, especially those who feel severely restricted due to the disease, are at high risk of developing vitamin D deficiency, secondary hyperparathyroidism, and ultimately osteomalacia due to immobilization and subsequent lack of exposure to sunlight, all of which in turn lead to further deterioration. Monitoring of vitamin D metabolism and vitamin D replacement therapy could be a simple, inexpensive approach to mitigating clinical symptoms and improving quality of life in patients with advanced

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2002 Journal of General Internal Medicine

16650. Acute infantile thrombocytosis and vitamin K deficiency associated with intracranial haemorrhage. (PubMed)

Acute infantile thrombocytosis and vitamin K deficiency associated with intracranial haemorrhage. 6990876 1980 07 26 2008 11 20 1468-2044 55 1 1980 Jan Archives of disease in childhood Arch. Dis. Child. Acute infantile thrombocytosis and vitamin K deficiency associated with intracranial haemorrhage. 84-5 Ozsoylu S S eng Case Reports Letter England Arch Dis Child 0372434 0003-9888 AIM IM Acute Disease Cerebral Hemorrhage etiology Humans Hyperostosis, Cortical, Congenital complications diagnosis (...) Infant Thrombocytosis etiology Vitamin E Deficiency complications Vitamin K Deficiency complications 1980 1 1 1980 1 1 0 1 1980 1 1 0 0 ppublish 6990876 PMC1626717

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1980 Archives of Disease in Childhood

16651. The effect of vitamin A deficiency on hepatic, renal and pulmonary glutathione S-transferase activities in the rat. (PubMed)

The effect of vitamin A deficiency on hepatic, renal and pulmonary glutathione S-transferase activities in the rat. Feeding male weanling rats on a vitamin A-deficient diet for 6 weeks resulted in significant increases (44-57%) in glutathione S-aryl-, S-aralkyl- S-alkyl- and S-epoxidetransferase activities in the liver cytosol. Only the S-aralkyl- (27%) and S-alkyltransferase (14%) activities were significantly increased in the kidney as a result of deficiency. There was no effect on any (...) of the pulmonary glutathione S-transferase activities. The increases in hepatic transferase activities were due primarily to increases (25-96%) in the apparent Vmax. There were no changes in the apparant Km of any of the four drug substrates employed. With 3,4-dichloronitrobenzene as the second substrate, the apparent Km for glutathione was increased by over 2-fold in vitamin A-deficient livers as compared with controls. The relationship between these results and enhanced susceptibility to chemical carcinogens

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1980 Biochemical Journal

16652. Impaired ability of patients with familial isolated vitamin E deficiency to incorporate alpha-tocopherol into lipoproteins secreted by the liver. (PubMed)

Impaired ability of patients with familial isolated vitamin E deficiency to incorporate alpha-tocopherol into lipoproteins secreted by the liver. Plasma and lipoprotein alpha-tocopherol concentrations of four patients with familial isolated vitamin E deficiency and six control subjects were observed for 4 d after an oral dose (approximately 15 mg) of RRR-alpha-tocopheryl acetate labeled with six deuterium atoms (d6-tocopherol). Chylomicron d6-tocopherol concentrations were similar in the two

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1990 Journal of Clinical Investigation

16653. Vitamin B-12 and folate deficiency presenting as leukemia. (PubMed)

Vitamin B-12 and folate deficiency presenting as leukemia. 2390611 1990 09 28 2018 11 13 0959-8138 301 6744 1990 Jul 21 BMJ (Clinical research ed.) BMJ Vitamin B-12 and folate deficiency presenting as leukemia. 180 Lennard A A eng Letter England BMJ 8900488 0959-8138 AIM IM Diagnosis, Differential Folic Acid Deficiency diagnosis Hematologic Tests Humans Leukemia diagnosis Vitamin B 12 Deficiency diagnosis 1990 7 21 1990 7 21 0 1 1990 7 21 0 0 ppublish 2390611 PMC1663516 BMJ. 1990 Jul 7;301(6742

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1990 BMJ : British Medical Journal

16654. Vitamin B-12 and folate deficiency presenting as leukaemia. (PubMed)

Vitamin B-12 and folate deficiency presenting as leukaemia. 2354298 1990 07 26 2018 11 13 0959-8138 300 6734 1990 May 12 BMJ (Clinical research ed.) BMJ Vitamin B-12 and folate deficiency presenting as leukaemia. 1263-4 Dokal I S IS Department of Haematology, Royal Postgraduate Medical School, London. Cox T M TM Galton D A DA eng Case Reports Journal Article Research Support, Non-U.S. Gov't England BMJ 8900488 0959-8138 AIM IM BMJ. 1990 Jul 7;301(6742):42 2383710 BMJ 1990 May 26;300(6736):1394 (...) Adult Diagnosis, Differential Female Folic Acid Deficiency diagnosis Humans Leukemia diagnosis Leukemia, Myeloid, Acute diagnosis Leukemia, Promyelocytic, Acute diagnosis Middle Aged Vitamin B 12 Deficiency diagnosis 1990 5 12 1990 5 12 0 1 1990 5 12 0 0 ppublish 2354298 PMC1662842 Br Med J. 1969 Jun 7;2(5657):612-3 5798473 Lancet. 1989 Sep 30;2(8666):789-91 2571022

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1990 BMJ : British Medical Journal

16655. Vitamin B-12 and folate deficiency presenting as leukaemia. (PubMed)

Vitamin B-12 and folate deficiency presenting as leukaemia. 2383710 1990 09 18 2018 11 13 0959-8138 301 6742 1990 Jul 07 BMJ (Clinical research ed.) BMJ Vitamin B-12 and folate deficiency presenting as leukaemia. 42 Lennard A A eng Comment Letter England BMJ 8900488 0959-8138 AIM IM BMJ. 1990 May 12;300(6734):1263-4 2354298 Anemia, Macrocytic diagnosis Anemia, Megaloblastic diagnosis Diagnosis, Differential Humans Leukemia, Myeloid, Acute diagnosis 1990 7 7 1990 7 7 0 1 1990 7 7 0 0 ppublish

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1990 BMJ : British Medical Journal

16656. Nutritional Problems in Cats: Taurine Deficiency and Vitamin A Excess (PubMed)

Nutritional Problems in Cats: Taurine Deficiency and Vitamin A Excess Two nutritional problems of the cat are reviewed. One represents a deficiency of taurine, the other vitamin A toxicity. Taurine deficiency in cats is insidious because the progressive retinal degeneration induced may go unnoticed until the damage is advanced and irreversible. Both rods and cones undergo degeneration along with the underlying tapetum lucidum. The hyperreflective focal lesion is easily observed in the area (...) centralis with an ophthalmoscope and has been previously identified as feline central retinal degeneration. This lesion is not reversed by taurine supplementation, even though the remaining retina may be saved from further degeneration. The cat requires dietary taurine, found in meat and fish, because it cannot synthesize enough to meet demands for bile acid conjugation and tissue metabolism, especially those of muscle and central nervous system. Vitamin A toxicity is not commonly observed in cats

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1982 The Canadian Veterinary Journal

16657. Studies on a family with combined functional deficiencies of vitamin K-dependent coagulation factors. (PubMed)

Studies on a family with combined functional deficiencies of vitamin K-dependent coagulation factors. Two siblings with m ild hemorrhagic symptoms had combined functional deficiencies of vitamin K-dependent clotting factors. Prothrombin (0.18-0.20 U/ml) and Stuart factor (Factor X, 0.18-0.20 U/ml) and Stuart factor (Factor X, 0.18-0.20 U/ml) were most severely affected. Antigenic amounts of affected coagulation factors were normal and normal generation of thrombin activity occurred (...) ; the functional deficiencies in clotting factors are totally corrected by oral or parenteral administration of vitamin K1.

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1982 Journal of Clinical Investigation

16658. Night vision in a case of vitamin A deficiency due to malabsorption. (PubMed)

Night vision in a case of vitamin A deficiency due to malabsorption. Night vision was tested electroretinographically and psychophysically in a vitamin A deficient patient before and after therapy. Vitamin A deficiency resulted from malabsorption due to a jeujunoileal bypass operation. Before therapy the patient had severely reduced cone and rod function. After the reversal operation, accompanied by 5 injections of a total of 500,000 units of vitamin A, complete recovery of cone and rod

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1983 The British journal of ophthalmology

16659. Impaired intestinal localization of mesenteric lymphoblasts associated with vitamin A deficiency and protein-calorie malnutrition. (PubMed)

Impaired intestinal localization of mesenteric lymphoblasts associated with vitamin A deficiency and protein-calorie malnutrition. We examined whether protein-calorie (PC) and vitamin A (VA) deficiencies altered the intestinal localization of mesenteric lymph node (MLN) lymphoblasts using an adoptive lymphocyte transfer method. MLN cells from donor rats were labelled in vitro with [125I]-deoxyuridine and injected i.v. into various recipients. Twenty-two to twenty-four hours after transfer (...) of labelled cells prepared from PC-deficient donors, the percentage of radioactivity in the small intestine of normal recipients was two-thirds of that detected after transfer of cell obtained from normal donors. When donor cells were obtained from rats suffering both PC and VA malnourishment, this decrease was even greater, being only one-third of the normal donor cell control. Other experiments indicated that the defect in localization behaviour was associated with the donor blasts and not the recipient

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1982 Immunology

16660. Defective binding of macrophages to bone in rodent osteomalacia and vitamin D deficiency. In vitro evidence for a cellular defect and altered saccharides in the bone matrix. (PubMed)

Defective binding of macrophages to bone in rodent osteomalacia and vitamin D deficiency. In vitro evidence for a cellular defect and altered saccharides in the bone matrix. In the osteomalacic as well as normal skeleton, few osteoclasts are associated with osteoid-covered bone surfaces. The reason for this particular cellular deficit is not clear, but may relate to the inability of osteoclasts and/or osteoclast precursors (monocyte-macrophages) to attach to immature, unmineralized bone matrix (...) , a step apparently essential for normal resorptive activity and osteoclast differentiation. In this study, we have examined cell-bone binding using macrophages (M phi) and bone isolated from vitamin D-deficient rats and hypophosphatemic, osteomalacic mice and from their normal counterparts. The data show that M phi-bone attachment is greatly reduced (P less than 0.001) in both vitamin D deficiency and hypophosphatemia, but that the mechanisms responsible for this reduction are apparently different

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1983 Journal of Clinical Investigation

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