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VitaminB12deficiency and impaired expression of amnionless during aging. Physical frailty and loss of mobility in elderly individuals lead to reduced independence, quality of life, and increased mortality. VitaminB12deficiency has been linked to several age-related chronic diseases, including in the musculo-skeletal system, where vitaminB12deficiency is generally believed to be linked to poor nutritional intake. In the present study, we asked whether aging and frailty associate (...) with altered vitaminB12 homeostasis in humans and investigated the underlying molecular mechanisms using preclinical models.We analysed a subset of the Singapore Longitudinal Aging Study and stratified 238 participants based on age and Fried frailty criteria. Levels of methyl-malonic acid (MMA), a marker for vitaminB12deficiency, and amnionless, the vitaminB12 co-receptor that anchors the vitaminB12 transport complex to the membrane of epithelial cells, were measured in plasma. In addition, vitamin
Can vitaminB12deficiency manifest with acute posterolateral or posterior cord syndrome? VitaminB12deficiency can cause varied neurological manifestations which are subacute to chronic in onset. Subacute combined degeneration of spinal cord is one such characteristic neurological manifestation of vitaminB12deficiency. We report a case series of five patients who presented with acute onset (<15 days) neurological manifestations due to vitaminB12deficiency. Detailed history and clinical (...) parenteral vitaminB12 supplementation. VitaminB12deficiency can present with acute neurological manifestations.
VitaminB12deficiency neuropathy; a rare diagnosis in young adults: a case report VitaminB12deficiency is a metabolic disorder with many causes. It often presents with megaloblastic anaemia and neurological disorders which entail prompt treatment. The diagnosis of VitaminB12deficiency is challenging in resource limited-settings due to limited access to diagnostic tools and unfamiliarity with the disease, owing to its rarity especially in young people.A 28 year old female Cameroonian (...) presented with progressive burning painful sensations on the upper trunk, paraesthesia and numbness of the upper and lower limbs for a period of 5 years. Before presenting to us, she had consulted in numerous health institutions for which she had been treated for diverse pathologies with no relieve of symptoms. After clinical and laboratory evaluation, a diagnosis of vitaminB12deficiency-associated neuropathy was made. She was placed on oral vitaminB12 supplements at 2 mg daily for 3 months. Follow
Recurrent stroke in a patient with vitaminB12deficiency and MTHFR mutation 29849257 2019 02 26 2163-0402 7 1 2017 Feb Neurology. Clinical practice Neurol Clin Pract Recurrent stroke in a patient with vitamin B 12 deficiency and MTHFR mutation. e1-e4 10.1212/CPJ.0000000000000248 Zacharia George G Department of Hematology and Oncology (GZ, DS), and Department of Neurosurgery (RAO), Lenox Hill Hospital, New York. Shani Dana D Department of Hematology and Oncology (GZ, DS), and Department
Sensory Neuronopathy Revealing Severe VitaminB12Deficiency in a Patient with Anorexia Nervosa: An Often-Forgotten Reversible Cause VitaminB12 (B12) deficiency is known to be associated with various neurological manifestations. Although central manifestations such as dementia or subacute combined degeneration are the most classic, neurological manifestations also include sensory neuropathies. However, B12deficiency is still rarely integrated as a potential cause of sensory neuronopathy (...) . Moreover, as many medical conditions can falsely normalize serum B12 levels even in the context of a real B12deficiency, some cases may easily remain underdiagnosed. We report the illustrating case of an anorexic patient with sensory neuronopathy and consistently normal serum B12 levels. After all classical causes of sensory neuronopathy were ruled out, her clinical and electrophysiological conditions first worsened after folate administration, but finally improved dramatically after B12
Nitrous oxideâ€“induced vitaminB12deficiency Nitrous oxide is a gas that is odorless, colorless, and has a sweet taste at room temperature. Nitrous oxide has several uses, including in surgery and dentistry (referred to as "laughing gas"), in automotive racing, and in aerosol spray propellants. The aerosol spray propellants that typically use nitrous oxide are whipped cream canisters and cooking sprays. Unfortunately, these over-the-counter household items are a source of nitrous oxide (...) that can be used for recreational use. The most popular is the use of industrial-grade canisters having the slang term "whippets." The nitrous oxide can be extracted by pushing the nozzle down slightly to the side and catching the released gas with a balloon. The contents of the balloon can then be directly inhaled, giving an instant feeling of euphoria. This is not a benign means to achieve a euphoric state but can cause severe nitrous oxide-induced B12deficiency, which is presented in this case
Investigation of the vitaminB12deficiency with peripheral neuropathy in patients with type 2 diabetes mellitus treated using metformin The relationship between vitaminB12deficiency and peripheral neuropathy has been shown in a number of previous studies. Metformin is the indispensable first-line treatment for type 2 diabetes mellitus (DM) worldwide. One of the adverse effects of the use of metformin is vitaminB12deficiency. In the present study, we investigated the relationship between (...) vitaminB12deficiency and peripheral neuropathy due to the use of metformin.Patient's laboratory and electromyography (EMG) data were retrospectively reviewed. Patients with no EMG report and other necessary information were excluded from the study.Eighty-six patients with type 2 DM using metformin were included in the study. Of these patients, 26 were males and 60 were females. The mean age of the patients was 55.1±7.7 years. The mean body mass index of the patients was 29.1±9.01 kg/m2. The mean
Prevalence of VitaminB12Deficiency in Patients with Type II Diabetes Mellitus on Metformin: A Study from Khyber Pakhtunkhwa Background Metformin is the most common oral hypoglycemic used and associated with certain abnormalities. The objective was to evaluate and define the occurrence and bases of vitaminB12deficiency amongst patients on Metformin for diabetes mellitus type II. Methods A cross-sectional study was conducted on 209 patients having diabetes type II between January-December (...) on metformin had statistically lower values of B12 (P = 0.01). For the patients who smoked, vitaminB12deficiency was significantly higher than those who did not smoke (p= <0.001). Also in patients using multivitamins, vitaminB12deficiency was lower compared to nonusers (p=0.05). Conclusion Our study shows that for the patients with type 2 diabetes (T2DM), long-term treatment with metformin and smoking are associated with higher chances of developing vitaminB12deficiency. Clinicians should, therefore
Perspectives on Peripheral Neuropathy as a Consequence of Metformin-Induced VitaminB12Deficiency in T2DM Peripheral neuropathy (PN) is a primary complication of type 2 diabetes mellitus (T2DM) and a direct manifestation of vitaminB12deficiency. Examining the effects of metformin use on PN status became imperative following clinical studies that showed the vitaminB12-lowering effect of the medication. The complexity of the topic and the inconsistency of the results warrant consideration
Neuropsychiatric and neurological problems among VitaminB12deficient young vegetarians To assess the frequency of neuropsychiatric and neurological problems in apparently healthy young vegetarians and estimate serum VitaminB12, methylmalonic acid (MMA), and folic acid levels.This prospective study was conducted in the Department of Biochemistry, Basic Medical Sciences Institute (BMSI), Jinnah Postgraduate Medical Center (JPMC), Karachi, Pakistan, in the years of 2012 and 2013. The data (...) % in the omnivore (p=0.002), paresthesias were 11% compared with 3% in the omnivores (p=0.04), peripheral neuropathy was 9% compared with 2% in the omnivores (p=0.05), psychosis was found in 11% subjects compared with 3% in the omnivores (p=0.04).Vegetarians have VitaminB12deficiency and are more prone to developing neuropsychiatric and neurological problems.
Pseudothrombotic microangiopathy and vitaminB12deficiency in pernicious anemia VitaminB12deficiency may present as pseudothrombotic microangiopathy. Pseudothrombotic microangiopathy is anemia, thrombocytopenia, and schistocytosis caused by vitaminB12deficiency. Pseudothrombotic microangiopathy may be mistaken for microangiopathic hemolytic anemia, confounding appropriate treatment. Evaluation of lactate dehydrogenase, reticulocyte count, bilirubin, and platelet count are most helpful (...) in differentiating pseudothrombotic microangiopathy from a true microangiopathic hemolytic anemia. A case of pseudothrombotic microangiopathy due to severe vitaminB12deficiency is presented.
Oral Cyanocobalamin is Effective in the Treatment of VitaminB12Deficiency in Crohnâ€™s Disease Cobalamin deficiency is common in patients with Crohn's disease (CD). Intramuscular cobalamin continues to be the standard therapy for the deficiency and maintenance treatment in these patients, although oral route has been demonstrated to be effective in other pathologies with impaired absorption. Our aims were to evaluate the efficacy of oral therapy in the treatment of cobalamin deficiency (...) deficiency and were treated with oral B12 to maintain their correct cobalamin levels. After a mean follow-up of 3 years, the oral route was effective as maintenance treatment in 81.7% of patients. A lack of treatment adherence was admitted by 46.6% of patients in who the oral route failed. In conclusion, our study shows that oral cyanocobalamin provides effective acute and maintenance treatment for vitaminB12deficiency caused by CD with or without ileum resection.
South Asian Ethnicity Is Related to the Highest Risk of VitaminB12Deficiency in Pregnant Canadian Women VitaminB12 (B12) adequacy during pregnancy is crucial for maternal health and optimal fetal development; however, suboptimal B12 status has been reported in pregnant Canadian women. Methylmalonic acid (MMA) is a sensitive indicator of B12 status. Since few studies have measured MMA during pregnancy in Canadian women, the objective of this study was to evaluate B12 status in pregnant women (...) living in Metro Vancouver, using both plasma total B12 and MMA. We recruited a convenience sample of 320 pregnant women between 20 and 35 gestational weeks from local healthcare facilities. Plasma total B12 concentrations indicative of deficiency (<148 pmol/L) and suboptimal B12 status (148-220 pmol/L) were found in 18% and 33% of the women, respectively. Normal plasma MMA concentration (<210 nmol/L) was observed in 82% of all women. Gestational age was a strong predictor of plasma total B12 and MMA
The Impact of VitaminB12Deficiency on Infant Gut Microbiota The Impact of VitaminB12Deficiency on Infant Gut Microbiota - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Impact of VitaminB12 (...) Description Go to Brief Summary: VitaminB12 plays important roles in DNA synthesis and neurological functions. VitaminB12deficiency is one of the most common micronutrient deficiencies and it has become increasingly more frequent in infants. The deficiency develops more often between 4 to 12 months of age, coinciding with the decreased fetal storage. The highest rates of vitaminB12deficiency were observed among infants who are breastfed by mothers receiving a diet low in vitaminB12. The main
Long-term Metformin Use and VitaminB12Deficiency in the Diabetes Prevention Program Outcomes Study. VitaminB12deficiency may occur with metformin treatment, but few studies have assessed risk with long-term use.To assess the risk of B12deficiency with metformin use in the Diabetes Prevention Program (DPP)/DPP Outcomes Study (DPPOS).Secondary analysis from the DPP/DPPOS. Participants were assigned to the placebo group (PLA) (n = 1082) or the metformin group (MET) (n = 1073) for 3.2 years (...) % confidence interval, 1.06–1.20). Anemia prevalence was higher in MET, but did not differ by B12 status. Neuropathy prevalence was higher in MET with low B12 levels.Long-term use of metformin in DPPOS was associated with biochemical B12deficiency and anemia. Routine testing of vitaminB12 levels in metformin-treated patients should be considered.
Long-term Metformin Therapy and Monitoring for VitaminB12Deficiency Among Older Veterans. To examine the association between long-term metformin therapy and serum vitaminB12 monitoring.Retrospective cohort study.A single Veterans Affairs Medical Center (VAMC), 2002-2012.Veterans 50 years or older with either type 2 diabetes and long-term metformin therapy (n = 3,687) or without diabetes and no prescription for metformin (n = 13,258).We determined diabetes status from outpatient visits (...) in the metformin-exposed group (439.2 pg/dL) compared to those without diabetes (522.4 pg/dL) (P = .0015). About 7% of persons with diabetes receiving metformin were vitaminB12deficient (<170 pg/dL) compared to 3% of persons without diabetes or metformin use (P = .0001). Depending on their age, metformin users were two to three times more likely not to receive vitaminB12 testing compared to those without metformin exposure, after adjusting for sex, race and ethnicity, body mass index, and number of years
VitaminB12deficiency from the perspective of a practicing hematologist. B12deficiency is the leading cause of megaloblastic anemia, and although more common in the elderly, can occur at any age. Clinical disease caused by B12deficiency usually connotes severe deficiency, resulting from a failure of the gastric or ileal phase of physiological B12 absorption, best exemplified by the autoimmune disease pernicious anemia. There are many other causes of B12deficiency, which range from severe (...) to mild. Mild deficiency usually results from failure to render food B12 bioavailable or from dietary inadequacy. Although rarely resulting in megaloblastic anemia, mild deficiency may be associated with neurocognitive and other consequences. B12deficiency is best diagnosed using a combination of tests because none alone is completely reliable. The features of B12deficiency are variable and may be atypical. Timely diagnosis is important, and treatment is gratifying. Failure to diagnose B12
Effect of High-Dose Vitamin D3 on Hospital Length of Stay in Critically Ill Patients With Vitamin D Deficiency: The VITdAL-ICU Randomized Clinical Trial PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?