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for patients already established on therapy. Advice on other injectable medicines commonly used in primary care is available . Non-dietary vitaminB12deficiency (such as pernicious anaemia etc.) Normal administration: administer hydroxocobalamin 1 mg intramuscularly every 2–3 months for life During the COVID-19 pandemic, options include: Alternatives to attending the GP surgery such as local pharmacies or home administration by district nurses should be explored Oral cyanocobalamin can be offered (...) at a dose of 1 mg per day until regular IM hydroxocobalamin can be resumed Dietary VitaminB12deficiency Normal administration: advise people either to take oral cyanocobalamin tablets 50–150 micrograms daily between meals or have a twice-yearly hydroxocobalamin 1 mg injection. In vegans, treatment may need to be life-long, whereas in other people with dietary deficiency replacement treatment can be stopped once the vitaminB12 levels have been corrected and the diet has improved. During the COVID-19
Spontaneous Left Anterior Descending Artery Dissection in a Middle-Aged Woman with VitaminB12Deficiency Treated with Coronary Artery Bypass Grafting Spontaneous coronary artery dissection (SCAD) is one of the rarest causes of acute coronary syndromes, which include myocardial infarction (MI), stable and unstable angina, cardiogenic shock, and sudden death. The course of the disease, its etiology, prevalence, prognosis, and treatment remain ill-defined. Adding to the complexity is the fact (...) that patients may lack typical risk factors for coronary heart disease. Herein, we report a case of a 42-year-old woman with vitaminB12deficiency, who presented with chest pain; electrocardiography (ECG) findings were consistent with the acute anterior wall MI. Cardiac catheterization was done, which showed a very large left anterior descending (LAD) artery dissection.
VitaminB12Deficiency Induces Imbalance in Melanocytes Homeostasisâ€”A Cellular Basis of Hypocobalaminemia Pigmentary Manifestations VitaminB12deficiency causes significant changes in cellular metabolism leading to various clinical symptoms, such as hematological, psychiatric, and neurological disorders. We hypothesize that skin pigmentation disorders may be a diagnostically important manifestation of vitaminB12deficiency, however the cellular and molecular mechanisms underlying (...) these effects remain unknown. The aim of this study was to examine the effect of vitaminB12deficiency on melanocytes homeostasis. Hypocobalaminemia in vitro model was developed by treating epidermal melanocytes with synthesized vitaminB12 antagonist-hydroxycobalamin(c-lactam). The cells were examined using immunoenzymatic, spectrophotometric, and fluorimetric assays as well as image cytometry. Significant melanogenesis stimulation-the increase of relative melanin content and tyrosinase activity up to 131
The Evaluation of Ophthalmic Findings in Women Patients With Iron and VitaminB12Deficiency Anemia To determine whether there are differences in the central corneal thickness (CCT), retinal nerve fiber layer (RNFL), and ganglion cell-inner plexiform layer (GC-IPL) in women with iron deficiency anemia (IDA) and vitaminB12deficiency anemia (B12DA).The patients were divided and evaluated in three groups as IDA (group 1), combined IDA-B12DA (group 2), and healthy females (group 3). Each group
Diagnostic value of oral â€œbeefy redâ€ patch in vitaminB12deficiencyVitaminB12deficiency, which may cause serious neuropsychiatric damage, is common in the elderly. The non-specific clinical features of B12deficiency and unreliable serum parameters make diagnosis difficult. We aimed to evaluate the value of oral "beefy red" patches as a clinical marker of B12 deficiency.A diagnostic study was conducted in patients complaining of oral soreness, burning sensation, or severe recurrent oral (...) ulcers. Patients underwent clinical examination and laboratory investigations, including complete blood count and estimation of serum B12, folate, iron, and ferritin levels. Resolution of clinical signs and symptoms after 1 month of B12 supplement was regarded as the diagnostic gold standard.Of 136 patients, 70 had B12deficiency. Among these patients, the oral "beefy red" patch was observed in 61, abnormal mean corpuscular volume (MCV) was noted in 30, and serum cobalamin levels <200 and <350 pg/mL
VitaminB12deficiency-induced pseudothrombotic microangiopathy without macrocytosis presenting with acute renal failure: a case report VitaminB12deficiency-induced thrombotic microangiopathy, known as pseudothrombotic microangiopathy, is a rare condition which resembles the clinical features of thrombotic thrombocytopenic purpura but requires a markedly different treatment. Most cases of vitaminB12deficiency have only mild hematological findings, but in approximately 10% of patients life (...) of vitaminB12 and rapid restitutio ad integrum with its replacement supported the diagnosis of pseudothrombotic thrombocytopenic purpura caused by vitaminB12 deficiency.Diagnosis of pseudothrombotic thrombocytopenic purpura caused by vitaminB12deficiency might be difficult. Awareness of clinicians toward this differential diagnosis might spare patients from unnecessary therapeutic plasma exchange that is burdened by morbidity and mortality.
The influence of thyroid diseases, diabetes mellitus, primary hyperparathyroidism, vitaminB12deficiency and other comorbid autoimmune diseases on treatment outcome in patients with rheumatoid arthritis: An exploratory cohort study. To investigate the impact of comorbid diseases on rheumatoid arthritis (RA) outcome.All patients diagnosed with RA since 2006, who were registered in our local Danbio registry, were included in this cohort study. Patients' demographics, serology results (...) , and Disease Activity Score in 28 joints-C-reactive protein (DAS28-CRP) at the time of diagnosis and after 4 months of treatment initiation were collected. Patients' electronic hospital records were evaluated for a positive history of thyroid diseases, diabetes mellitus, primary hyperparathyroidism, vitaminB12deficiency, and the presence of other diagnosed autoimmune diseases.1035 RA patients were included. The observed prevalence of thyroid diseases was 11.8%, DM 10.4%, primary hyperparathyroidism 2.8
VitaminB12Deficiency as a Cause of Neurotrophic Keratopathy Neurotrophic keratitis is a rare degenerative corneal disease caused by an impairment of trigeminal corneal innervation, leading to a decrease or absence of corneal sensation. Here, we present a case of neurotrophic keratopathy caused by B12deficiency in a 34 years old man who had a progressive decrease in visual acuity and corneal involvement since 3 months before being referred to our ophthalmology clinic.Based on our clinical (...) findings and with the diagnosis of B12deficiency we started B12 treatment for the patient. After 3 weeks the patient showed a dramatic response with corneal sensation reversal, an increase of visual acuity, improved neurotrophic keratopathy and significantly improved neurological findings. To the best of our knowledge, there is no report regarding vitaminB12deficiency induced keratopathy and this is the first report that describes this aspect of vitaminB12deficiency.
Psychomotor regression due to vitaminB12deficiency A vitaminB12deficiency in infants is rare, but may sometimes be seen in breastfed babies of strict vegetarian mothers. VitaminB12, also known as cobalamin, is only found in meat and other animal products. Most babies have a sufficient supply as long as the mother was not deficient herself. Symptoms and signs of vitaminB12deficiency appear between the ages of 2 to 12 months and include vomiting, lethargy, failure to thrive, hypotonia (...) , and arrest or regression of developmental skills. Urinary concentrations of methylmalonic acid and homocystine are characteristically elevated in vitaminB12deficiency. Early treatment for a vitaminB12deficiency in an infant involves immediate administration of vitaminB12 to the baby and the breastfeeding mother. The infant and mother will each receive an injection of vitaminB12 containing 1,000 mcg or more of the vitamin, and the mother will continue to receive injections every month to raise her
VitaminB12 and folate deficiencies are not associated with nutritional or weight status in older adults. It is not known whether undernutrition causes vitaminB12 and folate deficiencies. The present study aimed to determine whether nutritional status, measured using the Mini Nutritional Assessment (MNA) scale, and body mass index (BMI) are indicators of lower level serum vitaminB12 and folate in older adults. 1007 outpatients aged 65 years or over were included the study. MNA scores >23.5 (...) , 17-23.5, <17, were categorized as normal nutritional status, risk of malnutrition, and malnutrition, respectively. Weight status was assessed using BMI and categorized as under or normal weight (<25 kg/m2), overweight (25-30 kg/m2), class I obese (30.0-35 kg/m2), class II obese (35-40 kg/m2), and class III obese (≥40 kg/m2). VitaminB12 and folate deficiencies were defined as <200 pg/ml and <3 ng/ml, respectively. Among 1007 patients with an average age of 74.3 ± 8.2 years, 6.9% were categorized
Thalassemia minor presenting with vitaminB12deficiency, paraparesis, and microcytosis VitaminB12 is essential for proper neurological functioning, and its deficiency may cause a wide range of neuropsychiatric and hematological manifestations. We report a case of a previously healthy 32-year-old female who was admitted to our hospital with sudden onset of bilateral lower limb paraparesis and loss of sensation. The serum level of vitaminB12 was mildly decreased with high methylmalonic acid (...) and homocysteine levels. However, her complete blood count showed no evidence of anemia or macrocytosis; instead, her mean corpuscular volume was low. Hemoglobin electrophoresis showed thalassemia trait, and that probably masked the megaloblastic features of vitaminB12deficiency. She responded fully to vitaminB12 replacement therapy.
Behavioral alterations are associated with vitaminB12deficiency in the transcobalamin receptor/CD320 KO mouse. VitaminB12 (cobalamin) deficiency is prevalent worldwide and causes megaloblastic anemia and neurologic deficits. While the anemia can be treated, the neurologic deficits can become refractive to treatment as the disease progresses. Therefore, timely intervention is critical for a favorable outcome. Moreover, the metabolic basis for the neuro-pathologic changes and the role (...) of cobalamin deficiency in the pathology still remains unexplained. Using a transcobalamin receptor / CD320 knockout mouse that lacks the receptor for cellular uptake of transcobalamin bound cobalamin, we aimed to determine whether cobalamin deficiency in the central nervous system produced functional neurologic deficits in the mouse that would parallel those observed in humans. Our behavioral analyses indicate elevated anxiety and deficits in learning, memory and set-shifting of a spatial memory task
Systematic review of prevalence of vitaminB12deficiency among vegans, including biological monitoring. Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files
Vitamin C deficiencyVitamin C deficiency - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search Vitamin C deficiency Last reviewed: February 2019 Last updated: December 2017 Summary Scurvy is a rare disorder, with epidemics typically affecting populations subject to famine or displacement during wartime. Most key clinical manifestations are related to impaired collagen synthesis. These include bleeding complications (...) (spontaneous petechiae and ecchymoses), friable gingiva and loose teeth, bone pain, and joint effusions. Other complications include heart failure, encephalopathy, and entrapment neuropathies. If not treated promptly, scurvy can be fatal. Complete recovery is anticipated in most patients. Definition Scurvy is a life-threatening condition due to dietary vitamin C deficiency. Those affected are mostly refugees or victims of famine, alcoholics, older people, fad dieters, or children with autism
High Prevalence of VitaminB12Deficiency and No Folate Deficiency in Young Children in Nepal Many children in low- and middle-income countries may have inadequate intake of vitaminB12 and folate; data confirming these inadequacies are limited. We used biochemical, demographic, behavioral and anthropometric data to describe the folate and vitaminB12 concentrations among six- to 23-month-old Nepalese children. VitaminB12 (serum B12 < 150 pmol/L) and folate deficiencies (red blood cell (RBC (...) ) folate < 226.5 nmol/L) were assessed. We used logistic regression to identify predictors of vitaminB12deficiency. The vitaminB12 geometric mean was 186 pmol/L; 30.2% of children were deficient. The mean RBC folate concentration was 13,612 nmol/L; there was no deficiency. Factors associated with vitaminB12deficiency included: (a) age six to 11 months (adjusted odds ratio (aOR) 1.51; 95% confidence interval (CI): 1.18, 1.92) or 12-17 months (aOR 1.38; 95% CI: 1.10, 1.72) compared to 18-23 months
Which oral vitamin D dosing regimens correct deficiency in pregnancy? Which oral vitamin D dosing regimens correct deficiency in pregnancy? – SPS - Specialist Pharmacy Service – The first stop for professional medicines advice Menu · · Published 23rd January 2019, updated 23rd January 2019 · UKMi This UKMi Q&A evaluates the available evidence at the time of publication to address issues associated with vitamin D dosing in pregnancy Attachments · Word · 150 KB Regional Medicines Information
Early High-Dose Vitamin D3 for Critically Ill, Vitamin D-Deficient Patients. Vitamin D deficiency is a common, potentially reversible contributor to morbidity and mortality among critically ill patients. The potential benefits of vitamin D supplementation in acute critical illness require further study.We conducted a randomized, double-blind, placebo-controlled, phase 3 trial of early vitamin D3 supplementation in critically ill, vitamin D-deficient patients who were at high risk (...) for death. Randomization occurred within 12 hours after the decision to admit the patient to an intensive care unit. Eligible patients received a single enteral dose of 540,000 IU of vitamin D3 or matched placebo. The primary end point was 90-day all-cause, all-location mortality.A total of 1360 patients were found to be vitamin D-deficient during point-of-care screening and underwent randomization. Of these patients, 1078 had baseline vitamin D deficiency (25-hydroxyvitamin D level, <20 ng per