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Vitamin B12 Deficiency

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181. Effects of metformin versus placebo on Vitamin B12 metabolism in non-diabetic breast cancer patients in CCTG MA.32 (PubMed)

(124-137) (p = 0.38), and at 6 months, metformin, 131 g/L (91-162), and 131 g/L (106-169) in placebo group (p = 0.11). Of the 74 subjects with vitamin B12 <222 pmol/L at either time point (45 metformin, 29 placebo), at baseline MMA was normal in all patients and two had elevated HC (>15μmol/L). At 6 months, one patient (metformin) had MMA >0.4μmol/L and 3 (2 metformin, 1 placebo) had HC > 15μmol/L.There was an increased rate of biochemical VitB12 deficiency after 6 months of metformin (...) Effects of metformin versus placebo on Vitamin B12 metabolism in non-diabetic breast cancer patients in CCTG MA.32 Metformin is associated with low levels of vitamin B12 (VitB12) in patients with diabetes. The CCTG/MA.32 trial investigates the effects of metformin vs placebo on breast cancer (BC) outcomes in non-diabetic high-risk BC patients. We analyzed VitB12 at baseline and after 6 months of metformin (versus placebo) in the first 492 patients with paired blood samples.VitB12 was analyzed

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2017 Breast cancer research and treatment Controlled trial quality: uncertain

182. Addition of vitamin B12 to exercise training improves cycle ergometer endurance in advanced COPD patients: A randomized and controlled study. (PubMed)

deficiency was high (34.4%) and there was a statistically significant interaction (p < 0.05), favoring a global effect of supplementation on exercise tolerance in the supplemented groups compared to the non-supplemented groups, even after adjusting for confounding variables (p < 0.05). The same was not found for the kinetics adjustment variables (τV'O2p and MRTV'O2p, p > 0.05 for both). Supplementation with vitamin B12 appears to lead to discrete positive effects on exercise tolerance in groups (...) Addition of vitamin B12 to exercise training improves cycle ergometer endurance in advanced COPD patients: A randomized and controlled study. Vitamin B12 is essential in the homocysteine, mitochondrial, muscle and hematopoietic metabolisms, and its effects on exercise tolerance and kinetics adjustments of oxygen consumption (V'O2p) in rest-to-exercise transition in COPD patients are unknown. This randomized, double-blind, controlled study aimed to verify a possible interaction between vitamin

2017 Respiratory medicine Controlled trial quality: predicted high

183. Association between serum vitamin B12 level and frailty in older adults (PubMed)

demonstrated to be related to numerous geriatric syndromes.Total of 335 patients who presented at geriatric outpatient clinic and underwent comprehensive geriatric assessment were included in this study. All patients were evaluated with both Fatigue, Resistance, Ambulation, Illnesses, and Loss of Weight (FRAIL) scale and Fried criteria for frailty. Vitamin B12 deficiency was defined as serum vitamin B12 level of less than 400 pg/mL.In total of 335 patients, 88 (26.3%) were assessed as frail, 156 (46.6 (...) Association between serum vitamin B12 level and frailty in older adults Frailty is associated with recurrent falls, fractures, limitation of daily living activities, cognitive impairment, increase in hospitalization, placement in nursing home, and mortality rate in older adults. Although malnutrition is one of the most important etiological factors, role of micronutrients is unclear. The aim of this study was to investigate association between frailty and vitamin B12, which has been

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2017 Northern clinics of Istanbul

184. In patients on Metformin with vitamin b12 deficiency, is it worth trying oral b12 supplements rather than initiating treatment by injection immediately?

In patients on Metformin with vitamin b12 deficiency, is it worth trying oral b12 supplements rather than initiating treatment by injection immediately? In patients on Metformin with vitamin b12 deficiency, is it worth trying oral b12 supplements rather than initiating treatment by injection immediately? - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT (...) ’ and this is something we aim to deliver for every single search. As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news. For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com In patients on Metformin with vitamin b12 deficiency, is it worth trying oral b12

2012 TRIP Answers

185. Gestational vitamin D deficiency and autism spectrum disorder (PubMed)

Gestational vitamin D deficiency and autism spectrum disorder There is growing interest in linking vitamin D deficiency with autism spectrum disorders (ASDs). The association between vitamin D deficiency during gestation, a critical period in neurodevelopment, and ASD is not well understood.To determine the association between gestational vitamin D status and ASD.Based on a birth cohort (n=4334), we examined the association between 25-hydroxyvitamin D (25OHD), assessed from both maternal mid (...) -gestation sera and neonatal sera, and ASD (defined by clinical records; n=68 cases).Individuals in the 25OHD-deficient group at mid-gestation had more than twofold increased risk of ASD (odds ratio (OR)=2.42, 95% confidence interval (CI) 1.09 to 5.07, P=0.03) compared with the sufficient group. The findings persisted in analyses including children of European ethnicity only.Mid-gestational vitamin D deficiency was associated with an increased risk of ASD. Because gestational vitamin D deficiency

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2017 BJPsych open

186. Association between vitamin D deficiency and heart failure risk in the elderly (PubMed)

Association between vitamin D deficiency and heart failure risk in the elderly The aim of this study was to evaluate the association between vitamin D deficiency and risk of heart failure in elderly patients of cardiology outpatient clinics.A cross-sectional study with an analytical approach was employed. Clinical data were collected from the elderly from August 2015 to February 2016. The dependent variable was the risk of heart failure; the independent variable was vitamin D deficiency (...) ; and intervening factors were age, gender, education, ethnicity, hypertension, diabetes mellitus, hypothyroidism, renal failure, dementia, stroke, dyslipidaemia, depression, smoking, alcoholism, obesity, andropause, and cardiac arrhythmia. To analyse the association between vitamin D deficiency and risk of heart failure, we used the bivariate logistic analysis, followed by analysis through the multivariate logistic regression model. Of the 137 elderly, the study found the following: women (75.9%); overweight

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2017 ESC heart failure

187. Vitamin D deficiency in patients with dry eye syndrome and primary Sjogren's syndrome: a systematic review and meta-analysis

Vitamin D deficiency in patients with dry eye syndrome and primary Sjogren's syndrome: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

188. A systematic review of the effects of vitamin D deficiency on performance in athletes and physical activity practitioners

A systematic review of the effects of vitamin D deficiency on performance in athletes and physical activity practitioners Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

189. Association between vitamin D deficiency and obesity in children and adolescents: systematic review

Association between vitamin D deficiency and obesity in children and adolescents: systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external

2019 PROSPERO

190. The accuracy of methods compared to HPLC for the diagnosis of vitamin A deficiency based on concentrations of serum retinol

The accuracy of methods compared to HPLC for the diagnosis of vitamin A deficiency based on concentrations of serum retinol Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

191. Deficiency of vitamin D during pregnancy. Preeclampsia and prematurity

Deficiency of vitamin D during pregnancy. Preeclampsia and prematurity Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation

2019 PROSPERO

192. Among pediatric patients with eosinophilic esophagitis, what are the rates of vitamin deficiency?

Among pediatric patients with eosinophilic esophagitis, what are the rates of vitamin deficiency? Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external

2019 PROSPERO

193. Vitamin B12

including hydroxocobalamin and cyanocobalamin. Both of these forms of vitamin B12 have been used in the prophylaxis and treatment of anaemia due to vitamin B12 deficiency. Hydroxocobalamin is also used in much higher doses as an antidote for cyanide poisoning. No specific UK guidelines regarding vitamin B12 supplementation during pregnancy currently exist. The RCOG states that there is no strong evidence to support routine supplementation of the B vitamins (with the exception of folic acid) during (...) a deficiency state exists, or where vitamin B12 is required in the management of maternal illness or poisoning, treatment should not be withheld. The use of supplemental vitamin B12 at any stage in pregnancy would not usually be regarded as medical grounds for termination of pregnancy or any additional fetal monitoring. Where use of high-dose vitamin B12 has been administered as an antidote during pregnancy in maternal poisoning, enhanced antenatal surveillance may be warranted and should be decided

2014 UK Teratology Information Service

194. Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency. (PubMed)

Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency. Proton pump inhibitors (PPIs) and histamine 2 receptor antagonists (H2RAs) suppress the production of gastric acid and thus may lead to malabsorption of vitamin B12. However, few data exist regarding the associations between long-term exposure to these medications and vitamin B12 deficiency in large population-based studies.To study the association between use of PPIs and H2RAs and vitamin B12 deficiency (...) in a community-based setting in the United States.We evaluated the association between vitamin B12 deficiency and prior use of acid-suppressing medication using a case-control study within the Kaiser Permanente Northern California population. We compared 25,956 patients having incident diagnoses of vitamin B12 deficiency between January 1997 and June 2011 with 184,199 patients without B12 deficiency. Exposures and outcomes were ascertained via electronic pharmacy, laboratory, and diagnostic databases.Risk

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2013 JAMA

195. Guideline for the management of vitamin D deficiency in HIV positive children: screening, treatment and prevention

Guideline for the management of vitamin D deficiency in HIV positive children: screening, treatment and prevention Guideline for the management of vitamin D deficiency in HIV positive children: screening, treatment and prevention Authors: Sarah Atkinson and Caroline Foster Date of preparation: February 2011 Version SMH/CF for 20,000 unit capsules Date reviewed: February 2014 Next review: February 2016 Content: 1. Algorithm for the management of vitamin D deficiency. 2. Summary of guidelines 3 (...) . Full guidelines 2. SUMMARY Vitamin D is required for skeletal and non-skeletal health including bone mineralization, innate immunity and cardiovascular health [1]. Both HIV infection and vitamin D deficiency are associated with reduced bone mineral density (BMD), increased risk of tuberculosis, and cardiovascular disease [1-3]. Vitamin D levels of =25 nmol/L (=10 µg/L) are associated with rickets and osteomalacia [4] and levels of >75 nmol/L (30 µg/L) are required for maximal BMD [5]. children

2014 The Children's HIV Association

196. Vitamin D deficiency in adults - treatment and prevention

Vitamin D deficiency in adults - treatment and prevention Vitamin D deficiency in adults - treatment and prevention - NICE CKS Share Vitamin D deficiency in adults - treatment and prevention: Summary Vitamin D is a fat soluble vitamin that regulates calcium and phosphate homeostasis and is therefore vital for musculoskeletal health. There are two main forms: vitamin D 3 (cholecalciferol) and D 2 (ergocalciferol). Vitamin D 3 is synthesized in the skin by the action of sunlight. Both vitamin D 3 (...) D status. However, there is no clear consensus on the threshold concentration used to define vitamin D deficiency in adults. Evidence identified by the Scientific Advisory Committee on Nutrition (SACN) suggests that the risk of poor musculoskeletal health is increased at serum 25(OH)D concentration below 25 nmol/L. People with insufficient exposure to sunlight and those with darker skin are at higher risk of vitamin D deficiency. Other risk factors include nutritional deficiency, certain

2018 NICE Clinical Knowledge Summaries

197. Vitamin D deficiency and health-related quality of life in chronic hepatitis C. (PubMed)

Vitamin D deficiency and health-related quality of life in chronic hepatitis C. 30739371 2019 03 05 1365-2893 2019 Feb 09 Journal of viral hepatitis J. Viral Hepat. Vitamin D deficiency and health-related quality of life in chronic hepatitis C. 10.1111/jvh.13076 Palazzo Donatella D Hepatology Unit, Department of Clinical Medicine, Sapienza University of Rome, Rome, Italy. Biliotti Elisa E https://orcid.org/0000-0002-4540-1815 Hepatology Unit, Department of Clinical Medicine, Sapienza University (...) , Rome, Italy. eng Journal Article 2019 02 09 England J Viral Hepat 9435672 1352-0504 : chronic hepatitis C health survey short form-36 health-related quality of life vitamin D 2018 07 19 2019 01 11 2019 2 11 6 0 2019 2 11 6 0 2019 2 11 6 0 aheadofprint 30739371 10.1111/jvh.13076

2019 Journal of viral hepatitis

198. Vitamin D deficiency in solid-organ transplant recipients from a Spanish Mediterranean population. (PubMed)

Vitamin D deficiency in solid-organ transplant recipients from a Spanish Mediterranean population. Solid-organ transplant recipients (SOTRs) are at risk of developing vitamin D deficiency, mainly caused by reduced sunlight exposure with subsequent low vitamin D synthesis in the skin.To analyse whether SOTRs from a Spanish Mediterranean region were vitamin D-deficient.This was a cross-sectional, descriptive and observational study in a transplantation-specialized Dermatological Unit from (...) a Mediterranean area to determine the calcidiol levels of a cohort of 78 consecutively attending patients not receiving vitamin D supplements. Serum 25(OH)D3 levels were determined and clinical characteristics were collected. Logistic regression analysis was used to analyse variables associated with dichotomized 25(OH)D3 levels (≤ or > 10 ng/mL).The cohort comprised 30 lung, 29 kidney and 19 liver transplant recipients. Mean calcidiol was 18 ± 9 ng/mL. Deficiency of 25(OH)D3 was present in 19% of patients

2019 Clinical & Experimental Dermatology

199. Evaluation of tracer labelled methionine load test in vitamin B-12 deficient adolescent women. (PubMed)

Evaluation of tracer labelled methionine load test in vitamin B-12 deficient adolescent women. Methionine loading test (MLT) has been used primarily to identify defects in transsulfuration of homocysteine in cystathionine beta synthase deficiency. It may not be as useful to evaluate remethylation pathway, in vitamin B-12 and folate deficiencies.We used tracer isotope labelled MLT to interrogate transsulfuration and remethylation independently in vitamin B-12 deficiency.We studied vitamin B-12 (...) deficient women with a tracer labelled MLT before and eleven months after treatment with vitamin B-12. The fractional contribution of [13C]homocysteine to breath CO2 was used as a measure of transsulfuration, and difference in the intracellular enrichment of [13C]methionine and that of [C2H3]methionine as a measure of remethylation of homocysteine. Combined pre- and post-treatment results were analyzed to investigate the association between plasma vitamin B-12 concentrations and measures of homocysteine

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2018 PLoS ONE

200. Risk factors of vitamin D deficiency among 15-year-old adolescents participating in the Malaysian Health and Adolescents Longitudinal Research Team Study (MyHeARTs). (PubMed)

Risk factors of vitamin D deficiency among 15-year-old adolescents participating in the Malaysian Health and Adolescents Longitudinal Research Team Study (MyHeARTs). This study is to determine the prevalence and risk factors of vitamin D deficiency (vitamin D ≤ 50 nmol/L) among 15-year-old Malaysian adolescents. By identifying potential risk factors, prevention strategies and interventions can be carried out to improve the vitamin D status in adolescents.Stratified random sampling design (...) ; mean age 15.1 ± 0.4 years). The prevalence of vitamin D deficiency was 33%. Mean vitamin D was lower in female (53 ± 15 nmol), obese (body fat percentage (≥25%m; ≥33.8%f) (56 ± 16 nmol/L), Malays (58 ± 18 nmol/L) and Indians (58 ± 15 nmol/L). In multivariate analysis, female (OR = 5.5; 95% CI: 3.4-7.5), Malay (OR = 3.2; 95% CI: 1.3-8.0), Indian (OR = 4.3; 95% CI: 1.6-12.0) and those always wearing long sleeve (OR = 2.4; 95% CI: 1.1-5.4) were more likely to have vitamin D deficiency. For female

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2018 PLoS ONE

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