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Vitamin B12 Deficiency

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181. Population-Based Incidence of Potentially Life-Threatening Complications of Hypocalcemia and the Role of Vitamin D Deficiency. (Abstract)

Population-Based Incidence of Potentially Life-Threatening Complications of Hypocalcemia and the Role of Vitamin D Deficiency. To determine the incidence of potentially life-threatening complications of hypocalcemia in infants and children in Olmsted County, Minnesota; and to determine if vitamin D deficiency contributed to these events and was, at the time of clinical presentation, considered as a possible cause.In this population-based descriptive study, data were abstracted from (...) life-threatening complication was 6.1 per 100 000 person-years (95% CI, 3.5-10.0).Vitamin D deficiency is an underinvestigated cause of complications of hypocalcemia in children. Serum calcium and 25-hydroxyvitamin D should be measured in children with these complications to identify possibly life-threatening vitamin D deficiency.Copyright © 2019 Elsevier Inc. All rights reserved.

2019 Journal of Pediatrics

182. Vitamin D deficiency and its relationship to cancer stage in patients who underwent thyroidectomy for papillary thyroid carcinoma. (Abstract)

Vitamin D deficiency and its relationship to cancer stage in patients who underwent thyroidectomy for papillary thyroid carcinoma. As imaging technology improves and more thyroid nodules and malignancies are identified, it is important to recognize factors associated with malignancy and poor prognosis. Vitamin D has proven useful as a prognostic tool for other cancers and may be similarly useful in thyroid cancer. This study explores the relationship of Vitamin D to papillary thyroid carcinoma (...) stage while accounting for socioeconomic covariates.The medical records of all patients who underwent thyroidectomy at one institution between 2000 and 2015 were reviewed. Subjects with non-papillary thyroid cancer pathology, prior malignancy, and without Vitamin D levels were excluded. The remaining 334 patient records were examined for cancer stage, Vitamin D levels, Vitamin D deficiency listed in history, and demographic and comorbid factors.Vitamin D laboratory values showed no significant

2019 American Journal of Otolaryngology

183. Hyperglycemia and metformin use are associated with B-vitamin deficiency and cognitive dysfunction in older adults. (Abstract)

was associated with higher risk of deficiency of vitamin B12 (combined B12 index ≤ -1; odds ratio (95% CI): 1.45 (1.03-2.02)) and vitamin B6 (plasma pyridoxal 5-phosphate <30.0 nmol/L; 1.48 (1.02-2.15)). Fortified foods when eaten regularly had a positive impact on all relevant B-vitamin biomarkers, even with hyperglycaemia. After adjustment for relevant co-variates, metformin use was associated with an increased risk of cognitive dysfunction as assessed using the RBANS (1.36 (1.03-1.80) and FAB (1.34 (1.03 (...) Hyperglycemia and metformin use are associated with B-vitamin deficiency and cognitive dysfunction in older adults. Emerging evidence suggests that deficiencies of folate-related B-vitamins can arise with metformin treatment and are independently linked with cognitive dysfunction, a co-morbidity of diabetes.To determine the impact of hyperglycemia and metformin use on relevant B-vitamin biomarkers and cognitive outcomes in older adults.Community-dwelling older people (74.1 ± 8.3 years, n = 4160

2019 Journal of Clinical Endocrinology and Metabolism

184. Vitamin D deficiency in solid-organ transplant recipients from a Spanish Mediterranean population. (Abstract)

Vitamin D deficiency in solid-organ transplant recipients from a Spanish Mediterranean population. Solid-organ transplant recipients (SOTRs) are at risk of developing vitamin D deficiency, mainly caused by reduced sunlight exposure with subsequent low vitamin D synthesis in the skin.To analyse whether SOTRs from a Spanish Mediterranean region were vitamin D-deficient.This was a cross-sectional, descriptive and observational study in a transplantation-specialized Dermatological Unit from (...) a Mediterranean area to determine the calcidiol levels of a cohort of 78 consecutively attending patients not receiving vitamin D supplements. Serum 25(OH)D3 levels were determined and clinical characteristics were collected. Logistic regression analysis was used to analyse variables associated with dichotomized 25(OH)D3 levels (≤ or > 10 ng/mL).The cohort comprised 30 lung, 29 kidney and 19 liver transplant recipients. Mean calcidiol was 18 ± 9 ng/mL. Deficiency of 25(OH)D3 was present in 19% of patients

2019 Clinical & Experimental Dermatology

185. Vitamin D deficiency is highly prevalent in malnourished inpatients and associated with higher mortality: A prospective cohort study. Full Text available with Trip Pro

Vitamin D deficiency is highly prevalent in malnourished inpatients and associated with higher mortality: A prospective cohort study. The impact of vitamin D deficiency on the recovery of patients with malnutrition remains undefined. Our aim was to study the prevalence of vitamin D deficiency in a well-characterized cohort of patients with malnutrition and its association with outcomes.Within this secondary analysis of a randomized controlled trial, we examined the association of vitamin D (...) deficiency and adverse clinical outcomes over a follow-up of 180 days in hospitalized patients at risk for malnutrition. We measured 25-hydroxyvitamin D levels upon admission and defined Vitamin D deficiency when levels were <50nmol/l. The primary endpoint was 180-day mortality.The prevalence of vitamin D deficiency in our cohort of 828 patients was 58.2% (n = 482). Patients with vitamin D deficiency had increased 180-day mortality rates from 23.1% to 29.9% (odds ratio 1.42, 95% confidence interval [CI

2019 Medicine

186. Vitamin D deficiency among patients with pulmonary hypertension. Full Text available with Trip Pro

Vitamin D deficiency among patients with pulmonary hypertension. There is little information about vitamin D (Vit D) deficiency in patients with pulmonary hypertension (PH). The objective of this study was: 1) compare Vit D levels between patients with PH, left ventricular failure (LVF) and healthy subjects (HS); 2) correlate, in patients with PH, Vit D levels with prognosis-related variables, such as the 6-min walk test (6MWT).Vitamin D levels were measured in a cross-sectional study in 126 (...) was made.Mean Vit D levels were lower in PH than in both other groups (ng/ml, mean ± SD): PH 19.25 ± 10, LVF 25.68 ± 12, HS 28.8 ± 12 (PH vs LVF p = 0.017, PH vs HS p = 0.001 and HS vs LVF p = 0.46). Vit D deficiency prevalence was higher in PH as compared to the other groups (PH 53.8%, LVF 45.2%, HS 25%, p = 0.01). Patients with PH in functional class (FC; WHO criteria) III-IV had higher Vit D deficiency prevalence than those in FC I-II (86.7% vs 40.5%, p = 0.003). There was a significant linear

2019 BMC pulmonary medicine

187. Vitamin D deficiency exacerbates bleomycin-induced pulmonary fibrosis partially through aggravating TGF-β/Smad2/3-mediated epithelial-mesenchymal transition. Full Text available with Trip Pro

Vitamin D deficiency exacerbates bleomycin-induced pulmonary fibrosis partially through aggravating TGF-β/Smad2/3-mediated epithelial-mesenchymal transition. Our earlier report indicated that active vitamin D3 inhibited epithelial-mesenchymal transition (EMT) in bleomycin (BLM)-induced pulmonary fibrosis. The objective of this study was to further investigate whether vitamin D deficiency exacerbates BLM-induced pulmonary fibrosis.This study consists of two independent experiments. Experiment 1 (...) , male mice were fed with vitamin D deficient (VDD) fodder. Experiment 2, Cyp27b1+/+, Cyp27b1+/- and Cyp27b1-/- mice were fed with standard diet. For pulmonary fibrosis, mice were intratracheally instilled with a single dose of BLM (1.5 mg/kg). Serum 25(OH) D level was measured. Pulmonary collagen deposition was assessed by Sirius red staining. EMT was measured and transforming growth factor-beta (TGF-β)/Smad3 signaling was evaluated in the lungs of BLM-treated mice.The relative weight of lungs

2019 Respiratory research

188. Association between Vitamin D deficiency and disease activity, disability and radiographic progression in early rheumatoid arthritis. The ESPOIR cohort. (Abstract)

Association between Vitamin D deficiency and disease activity, disability and radiographic progression in early rheumatoid arthritis. The ESPOIR cohort. To evaluate the association of baseline serum level of vitamin D (vitD) with disease activity, disability and radiographic damage over the first year in early rheumatoid arthritis (RA).Among early arthritis patients included in the ESPOIR cohort, patients with early RA were evaluated. 25OH vitamin D2D3 level was measured at baseline. Baseline (...) arthritis, data for 645 RA patients were analyzed. VitD level was <10 ng/ml (deficiency, group 1), 10-30 ng/ml (low level, group 2) and ≥30 ng/ml (normal, group 3) for 114 (17.7%), 415 (64.6%), and 114 (17.7%) patients, respectively. At baseline, DAS28-ESR and HAQ-DI were higher with vitD deficiency as compared with groups 2 and 3 combined (p=0.007 and p=0.001, respectively) as was mean mTSS but not significantly (p=0.076). On multivariate analysis, baseline vitD deficiency was associated with HAQ-DI

2019 Journal of Rheumatology

189. Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design. (Abstract)

Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design. Folate and vitamin B12 are well-known as essential nutrients that play key roles in the normal functions of the brain. Inflammatory processes play at least some role in the pathology of AD. Effective nutritional intervention approaches for improving cognitive deficits that reduce the peripheral (...) inflammatory cytokine levels have garnered special attention.The present study aimed to determine whether supplementation with folic acid and vitamin B12, alone and in combination improves cognitive performance via reducing levels of peripheral inflammatory cytokines.240 participants with MCI were randomly assigned in equal proportion to four treatment groups: folic acid alone, vitamin B12 alone, folic acid plus vitamin B12 or control without treatment daily for 6 months. Cognition was measured with WAIS

2019 Current Alzheimer research Controlled trial quality: uncertain

190. Evidence relating to B9 and B12 vitamin deficiencies and hypomagnesemia management: a systematic review

Evidence relating to B9 and B12 vitamin deficiencies and hypomagnesemia management: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web

2017 PROSPERO

191. is there any evidence to support the use of oral vitamin b12 (cyanocobalamin) instead of intramuscular preparation (hydroxycobalamin) instead for vitamin b12 deficiency or pernicious anaemia diagnosed

is there any evidence to support the use of oral vitamin b12 (cyanocobalamin) instead of intramuscular preparation (hydroxycobalamin) instead for vitamin b12 deficiency or pernicious anaemia diagnosed is there any evidence to support the use of oral vitamin b12 (cyanocobalamin) instead of intramuscular preparation (hydroxycobalamin) instead for vitamin b12 deficiency or pernicious anaemia diagnosed in primary care? - Trip Database or use your Google+ account Liberating the literature ALL (...) @tripdatabase.com is there any evidence to support the use of oral vitamin b12 (cyanocobalamin) instead of intramuscular preparation (hydroxycobalamin) instead for vitamin b12 deficiency or pernicious anaemia diagnosed in primary care? ATTRACT found mixed evidence on the use of oral vitamin B12 over intramuscular B12. A 2009 Cochrane systematic review (1) compared oral with intramuscular vitamin B12 therapy for Vitamin B12 deficiency. The authors conclude: “The evidence derived from these limited studies

2012 TRIP Answers

192. Metformin Use Is Not Associated With B12 Deficiency or Neuropathy in Patients With Type 2 Diabetes Mellitus in Qatar Full Text available with Trip Pro

Metformin Use Is Not Associated With B12 Deficiency or Neuropathy in Patients With Type 2 Diabetes Mellitus in Qatar Metformin may lead to B12 deficiency and neuropathy. There are no published data on the prevalence of Metformin-related B12 deficiency and neuropathy in the Arabian Gulf.Determine whether Metformin intake is associated with B12 deficiency and whether B12 deficiency is associated with diabetic peripheral neuropathy (DPN) and painful diabetic neuropathy.Patients with type 2 (...) diabetes mellitus (T2DM) (n = 362) attending outpatient clinics at HMC underwent assessment of B12 levels, the DN4 questionnaire, and vibration perception threshold (VPT).Comparing Metformin to non-Metformin users there were no differences in B12 levels, VPT, or DN4. The prevalence of B12 deficiency (B12 <133 pmol/l) was lower (P < 0.01) in Metformin (8%) compared to non-Metformin (19%) users. Patients with B12 deficiency had a comparable prevalence and severity of sensory neuropathy and painful

2018 Frontiers in endocrinology

193. Evidence From Web-Based Dietary Search Patterns to the Role of B12 Deficiency in Non-Specific Chronic Pain: A Large-Scale Observational Study. Full Text available with Trip Pro

Evidence From Web-Based Dietary Search Patterns to the Role of B12 Deficiency in Non-Specific Chronic Pain: A Large-Scale Observational Study. Profound vitamin B12 deficiency is a known cause of disease, but the role of low or intermediate levels of B12 in the development of neuropathy and other neuropsychiatric symptoms, as well as the relationship between eating meat and B12 levels, is unclear.The objective of our study was to investigate the role of low or intermediate levels of B12 (...) in the development of neuropathy and other neuropsychiatric symptoms.We used food-related Internet search patterns from a sample of 8.5 million people based in the US as a proxy for B12 intake and correlated these searches with Internet searches related to possible effects of B12 deficiency.Food-related search patterns were highly correlated with known consumption and food-related searches (ρ=.69). Awareness of B12 deficiency was associated with a higher consumption of B12-rich foods and with queries for B12

2018 Journal of medical Internet research

194. Vitamin B12 Supplementation to Improve B12 Status and Child Development

. The newborns and infants of B12-deficient mothers have low B12 stores at birth, further exacerbated by a very low concentration of B12 in breast milk that may hinder their growth and development. In regions such as Bangladesh, many women of reproductive age have inadequate B12 status, probably due to low intake of animal source food. Vitamin B12 intake and status in pregnancy and lactation is potentially insufficient to prevent impaired child development and immune function related to inadequate B12 status (...) Vitamin B12 Supplementation to Improve B12 Status and Child Development Vitamin B12 Supplementation to Improve B12 Status and Child Development - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Vitamin B12

2017 Clinical Trials

195. Pharmacologic therapy for vitamin D deficiency

Pharmacologic therapy for vitamin D deficiency Pharmacologic therapy for vitamin D deficiency Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics Pharmacologic therapy for vitamin D deficiency View/ Open Date 2013-02 Format Metadata Abstract Cholecalciferol (vitamin D3) supplementation should be used for vitamin D (...) repletion because it may be more effective in preventing nonvertebral fractures. (Strength of Recommendation [SOR]: B, based on subgroup analysis of randomized controlled trials [RCTs].) Cholecalciferol produces higher serum 25-hydroxyvitamin D levels than ergocalciferol (vitamin D2). Vitamin D therapy may be given daily or weekly with equal effectiveness; the dosage depends on the degree of deficiency. (SOR: C, based on an RCT and cohort study.) The cumulative dosage is more important than dosing

2013 Clinical Inquiries

196. Vitamin B12 and Cognitive Function

and Cognitive Function: OHTAC Recommendation. November 2013; pp. 1–11 5 Background An evidence-based analysis was conducted by Health Quality Ontario to answer the following research questions: 1) Is there an association between vitamin B12 deficiency and the onset of dementia or cognitive decline? 2) Does treatment with vitamin B12 supplementation improve cognitive function in patients with dementia or cognitive decline and vitamin B12 deficiency? 3) What is the effectiveness of oral versus parenteral (...) vitamin B12 supplementation in those with confirmed vitamin B12 deficiency? During the public consultation phase HQO received feedback from the Ontario Medical Association requesting an evidence review of other conditions for which vitamin B12 levels may be tested. Those conditions were neuropathy, alopecia, dizziness, and fatigue. Vitamin B12 and Cognitive Function: OHTAC Recommendation. November 2013; pp. 1–11 6 Conclusions Question 1: Is there an association between vitamin B12 deficiency

2013 Health Quality Ontario

197. Diagnosis of B12 and folate deficiency

using index terms including cobalamin, vitamin B12, folate, methylmalonic acid (MMA), homocysteine, holotranscobalamin, and combined with deficiency, treatment, pregnancy, oral contraceptive, metformin, bariatric surgery and infancy. Initial review of the manuscript was performed by members of the General Haematology Task Force of the British Committee for Standards in Haematology (BCSH), the executive committee, and a sounding board drawn from UK haematologists. Cobalamin deficiency In patients (...) Diagnosis of B12 and folate deficiency Guidelines for the diagnosis and treatment of cobalamin and folate disorders - Devalia - 2014 - British Journal of Haematology - Wiley Online Library By continuing to browse this site, you agree to its use of cookies as described in our . Search within Search term Search term The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Guideline Free Access Guidelines for the diagnosis and treatment of cobalamin and folate

2014 British Committee for Standards in Haematology

198. Screening for vitamin D deficiency: systematic review for the U.S. Preventive Services Task Force Recommendation

Screening for vitamin D deficiency: systematic review for the U.S. Preventive Services Task Force Recommendation Screening for vitamin D deficiency: systematic review for the U.S. Preventive Services Task Force Recommendation Screening for vitamin D deficiency: systematic review for the U.S. Preventive Services Task Force Recommendation LeBlanc E, Chou R, Zakher B, Daeges M, Pappas M Record Status This is a bibliographic record of a published health technology assessment. No evaluation (...) of the quality of this assessment has been made for the HTA database. Citation LeBlanc E, Chou R, Zakher B, Daeges M, Pappas M. Screening for vitamin D deficiency: systematic review for the U.S. Preventive Services Task Force Recommendation. Rockville: Agency for Healthcare Research and Quality (AHRQ). Evidence Synthesis No. 119. 2014 Authors' objectives The U.S. Preventive Services Task Force will use this report to develop a recommendation statement on screening for vitamin D deficiency in asymptomatic

2014 Health Technology Assessment (HTA) Database.

199. Vitamin D deficiency as a public health issue: using vitamin D2 or vitamin D3 in future fortification strategies. Full Text available with Trip Pro

Vitamin D deficiency as a public health issue: using vitamin D2 or vitamin D3 in future fortification strategies. The role of vitamin D in supporting the growth and maintenance of the skeleton is robust; with recent research also suggesting a beneficial link between vitamin D and other non-skeletal health outcomes, including immune function, cardiovascular health and cancer. Despite this, vitamin D deficiency remains a global public health issue, with a renewed focus in the UK following (...) the publication of Public Health England's new Dietary Vitamin D Requirements. Natural sources of vitamin D (dietary and UVB exposure) are limited, and thus mechanisms are needed to allow individuals to achieve the new dietary recommendations. Mandatory or voluntary vitamin D food fortification may be one of the mechanisms to increase dietary vitamin D intakes and subsequently improve vitamin D status. However, for the food industry and public to make informed decisions, clarity is needed as to whether

2017 Proceedings of the Nutrition Society

200. Vitamin B12 and cognitive function: OHTAC recommendation

B12 unless there is evidence of malabsorption. Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Cognitions; Dementia; Dietary Supplements; Vitamin B 12; Vitamin B 12 Deficiency Language Published English Country of organisation Canada Province or state Ontario English summary An English language summary is available. Address for correspondence Evidence Development and Standards, Health Quality Ontario, 130 Bloor Street West, 10th floor, Toronto, Ontario Canada M5S 1N5 (...) Vitamin B12 and cognitive function: OHTAC recommendation Vitamin B12 and cognitive function: OHTAC recommendation Vitamin B12 and cognitive function: OHTAC recommendation Ontario Health Technology Advisory Committee (OHTAC) Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Ontario Health Technology Advisory Committee (OHTAC). Vitamin B12

2014 Health Technology Assessment (HTA) Database.

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