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Vibrio Cellulitis

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41. Ceftaroline fosamil for injection (Teflaro)

. For the indication of ABSSSI, as part of a multi-day AIDAC meeting on November 8, 2008, the use of a non-inferiority trial design and justification for an NI margin in patients with severe cellulitis or wound infections was supported by adequate evidence in the historical literature. However, the treatment effect of antibacterials following primary incision and drainage in patients with abscesses could not be estimated. Hence, major abscesses lacking significant inflammatory components should be excluded in NI

2010 FDA - Drug Approval Package

42. Necrotizing Subcutaneous Infection

, or recent surgery. The infection has the potential for rapid local spread and systemic complications such as toxic shock. Type III NSTI is usually associated with aquatic injuries sustained in warmer coastal areas. Vibrio vulnificus is the usual pathogen. Type III infections share clinical similarities to Type II infections and may spread rapidly. Pathophysiology NSTI causes tissue ischemia by widespread occlusion of small subcutaneous vessels. Vessel occlusion results in skin infarction and necrosis (...) , and hypotension. Patients may be bacteremic or septic and may require aggressive hemodynamic support. may develop. Diagnosis Clinical examination Blood and wound cultures Diagnosis, made by history and examination, is supported by leukocytosis, soft-tissue gas on x-ray, positive blood cultures, and deteriorating metabolic and hemodynamic status. Necrotizing Subcutaneous Infection CHRIS BJORNBERG/SCIENCE PHOTO LIBRARY NSTI must be differentiated from , in which cellulitis, myositis, and myonecrosis often occur

2013 Merck Manual (19th Edition)

43. Bacterial infection

. It is caused by , and . is an acute infection of the deeper skin layers that spreads via with lymphatic system. is a diffuse of with severe inflammation of dermal and subcutaneous layers of the . Cellulitis can be caused by normal or by , and usually occurs through open skin, cuts, , cracks in the skin, , , , , intravenous , or sites of insertion. In most cases it is the skin on the face or lower legs that is affected, though cellulitis can occur in other tissues. Mechanisms of damage [ ] The symptoms (...) -iodide (TCI) agar for the isolation of Vibrio species from estuarine environments". Letters in Applied Microbiology . 36 (3): 150–151. : . . (PDF) . . 2006. ^ (PDF) . . Archived from (PDF) on 2015-05-01 . Retrieved 2015-05-03 . Brook, I (Oct 2008). "Actinomycosis: diagnosis and management". Southern Medical Journal . 101 (10): 1019–23. : . . Mabeza, GF; Macfarlane J (March 2003). "Pulmonary actinomycosis". European Respiratory Journal . 21 (3): 545–551. : . . . . 2001. . Retrieved 4 April 2011

2012 Wikipedia

44. Nonfoodborne Vibrio infections: an important cause of morbidity and mortality in the United States, 1997-2006. (PubMed)

and Prevention's Cholera and Other Vibrio Illness Surveillance system. The diagnosis of NFVI required isolation of Vibrio species from a patient with contact with seawater.Of 4754 Vibrio infections reported, 1210 (25%) were NFVIs. Vibrio vulnificus infections were the most common (accounting for 35% of NFVIs), with 72% of V. vulnificus infections reported from residents of Gulf Coast states. Infections due to V. vulnificus resulted in fever (72% of cases), cellulitis (85%), amputation (10%), and death (17%). V (...) Nonfoodborne Vibrio infections: an important cause of morbidity and mortality in the United States, 1997-2006. Infections due to Vibrio species cause an estimated 8000 illnesses annually, often through consumption of undercooked seafood. Like foodborne Vibrio infections, nonfoodborne Vibrio infections (NFVI) also result in serious illness, but awareness of these infections is limited.We analyzed illnesses occuring during the period 1997-2006 that were reported to the Centers for Disease Control

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2008 Clinical Infectious Diseases

45. Necrotising Fasciitis

, fascia or muscle). [ , ] Be aware that: Necrotising fasciitis is difficult to diagnose in its initial stages, as it mimics cellulitis. Important early clues are pain, tenderness and systemic illness out of proportion to the localised physical signs . Bullae and ecchymotic skin lesions also point to the condition (and are not normally found with cellulitis). [ ] A high index of suspicion is necessary and suspected cases should be referred immediately. Prompt surgical debridement is essential (...) people; occasionally accompanied by staphylococcal infection. Type 3 - Gram-negative monomicrobial infection : This includes marine organisms such as Vibrio spp. and Aeromonas hydrophila , which can occur following seawater contamination of wounds, injuries involving fish fins or stings, and raw seafood consumption - particularly in patients with chronic liver disease. These marine infections are particularly virulent and can be fatal within 48 hours. Type 4 - fungal infection : Zygomycetes after

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2008 Mentor

46. Cellulitis and Erysipelas

, Streptococcus anginosus (formerly known as Streptococcus milleri ), and Capnocytophaga canimorsus - following cat or dog bites. Vibrio vulnificus , Aeromonas hydrophila - following sea or fresh-water exposure. Erysipelothrix rhusiopathiae - in butchers, vets or fish handlers. Mycobacterium marinum - in aquarium keepers. It is therefore prudent to ascertain patients' occupations in poorly healing infections. Presentation Cellulitis Cellulitis is more commonly seen in the lower limbs and usually affects one (...) Cellulitis and Erysipelas Cellulitis and Erysipelas information. Patient | Patient TOPICS Try our Symptom Checker TREATMENT RESOURCES Try our Symptom Checker PROFESSIONAL Upgrade to Patient Pro / / Search Cellulitis and Erysipelas Authored by , Reviewed by | Last edited 11 Apr 2015 | Certified by This article is for Medical Professionals Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK and European

2008 Mentor

47. Medical Treatment of Colitis in Patients With Hermansky-Pudlak Syndrome

if all of the following criteria are met: Has given written informed consent prior to screening. Age 18 years old or greater. Has confirmed diagnosis of HPS prior to screening. Has confirmed diagnosis of IBD prior to screening. The presence of active disease as defined by a SCCAI score greater than or equal to 5. Negative results on stool examination for culture of enteric pathogens (Salmonella, Shigella, Yersinia, Campylobacter, Vibrio, E. coli O157/H7), Clostridium difficile toxin assay, enteric (...) . Has a PT INR greater than 1.3 or a PTT greater than 3 seconds compared to control value. Has the following cell counts: Platelet count less than 80,000 or greater than 950,000. White blood cell count less than 1200. Neutrophil count less than 700. Has a current infection requiring intravenous antibiotics, a serious local infection (e.g., cellulitis, abscess) or systemic infection (e.g., pneumonia, septicemia). Has a history of cancer within the past 5 years, with the exception of excised basal

2007 Clinical Trials

48. A Study for Patients With Complicated Skin and Skin Structure Infections

designed to evaluate the efficacy and safety of either a single dose of oritavancin or an infrequent dose of oritavancin (First dose on Day one with an option for a second dose on Day five) compared to the previously studied dosing regimen of 200mg oritavancin given once daily for 3 to 7 days. Condition or disease Intervention/treatment Phase Staphylococcal Skin Infections Wounds and Injuries Abscess Cellulitis Streptococcal Infections Drug: oritavancin Phase 2 Study Design Go to Layout table for study (...) shock syndrome or toxic-like syndrome presumed or proven infection caused by Clostridium species bone infections ischemic or gangrenous ulcers or wounds infections caused only by gram-negative bacteria infection of an artificial joint that cannot be removed infection of the scrotum, perineum or perianal region infection of a severe burn wound severe ear infection involving bone and/or cartilage infection following injury in water possibly containing Vibrio species or following a history of eating

2007 Clinical Trials

49. Necrotizing soft-tissue infections and sepsis caused by Vibrio vulnificus compared with those caused by Aeromonas species. (PubMed)

infections had a significantly lower systolic blood pressure at presentation (p = 0.006). The patients with Aeromonas infections who died had significantly lower white blood-cell counts (p = 0.03) with significantly fewer numbers of segmented white blood cells than those who died in the Vibrio vulnificus group (p = 0.01).The contact history of patients with a rapid onset of cellulitis can alert clinicians to a differential diagnosis of soft-tissue infection with Vibrio vulnificus (contact with seawater (...) Necrotizing soft-tissue infections and sepsis caused by Vibrio vulnificus compared with those caused by Aeromonas species. Vibrio and Aeromonas species, which can cause necrotizing fasciitis and primary septicemia, are members of the Vibrionaceae family and thrive in aquatic environments. Because the clinical symptoms and signs of necrotizing fasciitis and sepsis caused by these two bacteria are similar, the purposes of this study were to describe the clinical characteristics of Vibrio

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2007 The Journal of Bone and Joint Surgery. American Volume

50. Vibrio vulnificus and V. parahaemolyticus necrotising fasciitis in fishermen visiting an estuarine tropical northern Australian location. (PubMed)

Vibrio vulnificus and V. parahaemolyticus necrotising fasciitis in fishermen visiting an estuarine tropical northern Australian location. Three cases of severe necrotising fasciitis due to Vibrio vulnificus (two cases) and Vibrio parahaemolyticus (one case, fatal), have occurred in Caucasian tourists while fishing at a remote tropical northern Australian estuarine area. Infections were acquired over a 4-year period during the tourist fishing season (April to July 2000-2003), when water (...) temperatures range from 23 to 30 degrees C. They are notable for their geographical clustering in the remote western aspect of the Gulf of Carpentaria, an area characterised by sedimentary stratiform zinc-lead-silver deposits and a major mining operation. Patients presented with classical bullous cellulitis with necrotising fasciitis, accompanied by severe sepsis. Underlying risk factors were identified in each patient; in one instance, previously unrecognised haemochromatosis was diagnosed. Likely reasons

2007 Journal of Infection

51. Infections caused by halophilic marine Vibrio bacteria. (PubMed)

Infections caused by halophilic marine Vibrio bacteria. The authors reviewed patients who developed sepsis or soft tissue infections caused by marine Vibrio bacteria in Florida.Marine Vibrio bacteria are the most common bacteria found in seawater. They are concentrated in marine animals that feed by filtration such as oysters and clams. These bacteria can cause gastroenteritis, sepsis, cellulitis leading to necrotizing soft tissue infection after exposure to seawater or consumption of raw (...) in 27 patients. Vibrio species were cultured from the blood of 103 patients and from wounds or soft tissues of 113. An additional 5 patients had cellulitis but bacteria were not cultured from these sites. In patients in whom it could be determined, 93 had primary soft tissue infections and 82 had primary bacteremia. Twenty-four patients had necrotizing soft tissue infections and required surgical debridement. Three of these 24 patients required amputation. Thirty-seven (20.3%) patients died. Severe

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1993 Annals of Surgery

52. Vibrio fluvialis hemorrhagic cellulitis and cerebritis. (PubMed)

Vibrio fluvialis hemorrhagic cellulitis and cerebritis. We describe a case of Vibrio fluvialis hemorrhagic cellulitis and cerebritis following multiple fire-ant stings and wading in brackish water. A high index of suspicion is required for diagnosis of this specific pathogen and concordant infection. This is, to our knowledge, the first report of this type of wound infection.

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2005 Clinical Infectious Diseases

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