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Vertebral Osteomyelitis

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1. Vertebral Osteomyelitis, Discitis, and Spinal Epidural Abscess in Adults

Vertebral Osteomyelitis, Discitis, and Spinal Epidural Abscess in Adults Quality Department Guidelines for Clinical Care Inpatient Vertebral Osteomyelitis Guideline Team Team Leader Carol E. Chenoweth, MD Infectious Diseases Team Members Benjamin S. Bassin, MD Emergency Medicine Megan R. Mack, MD Internal Medicine Mark E. Oppenlander, MD Neurosurgery Douglas J. Quint, MD Radiology F. Jacob Seagull, PhD Medical Education Consultant Rakesh D. Patel, MD Orthopaedic Surgery Initial Release August (...) results. The ultimate judgment regarding any specific clinical procedure or treatment must be made by the physician in light of the circumstances presented by the patient. Vertebral Osteomyelitis, Discitis, and Spinal Epidural Abscess in Adults Patient Population: Adult patients with suspected or confirmed vertebral osteomyelitis, discitis, paravertebral abscess, or spinal epidural abscess. (This guideline does not address vertebral osteomyelitis associated with hardware placed at a previous surgery

2018 University of Michigan Health System

2. Selection of an appropriate empiric antibiotic regimen in hematogenous vertebral osteomyelitis. Full Text available with Trip Pro

Selection of an appropriate empiric antibiotic regimen in hematogenous vertebral osteomyelitis. Empiric antibiotic therapy for suspected hematogenous vertebral osteomyelitis (HVO) should be initiated immediately in seriously ill patients and may be required in those with negative microbiological results. The aim of this study was to inform the appropriate selection of empiric antibiotic regimens for the treatment of suspected HVO by analyzing antimicrobial susceptibility of isolated bacteria

2019 PLoS ONE

3. Clinical Practice Guidelines for the Diagnosis and Treatment of Native Vertebral Osteomyelitis in Adults

Clinical Practice Guidelines for the Diagnosis and Treatment of Native Vertebral Osteomyelitis in Adults Practice Guidelines Search Search Practice Guidelines Practice guidelines are systematically developed statements to assist practitioners and patients in making decisions about appropriate health care for specific clinical circumstances. Attributes of good guidelines include validity, reliability, reproducibility, clinical applicability, clinical flexibility, clarity, multidisciplinary

2015 Infectious Diseases Society of America

4. Mycobacterium abscessus ssp. abscessus infection progressing to empyema from vertebral osteomyelitis in an immunocompetent patient without pulmonary disease: a case report. Full Text available with Trip Pro

Mycobacterium abscessus ssp. abscessus infection progressing to empyema from vertebral osteomyelitis in an immunocompetent patient without pulmonary disease: a case report. Pleural involvement by non-tuberculous mycobacteria (NTM) in patients without distinct pulmonary disease is extremely rare. Vertebral osteomyelitis (VO) with or without pulmonary disease is also a rare clinical presentation of NTM infection, and pleural spread of NTM from VO has not been reported.A 63-year-old woman

2019 BMC pulmonary medicine

5. Outcomes of additional instrumentation in elderly patients with pyogenic vertebral osteomyelitis and previous spinal instrumentation. (Abstract)

Outcomes of additional instrumentation in elderly patients with pyogenic vertebral osteomyelitis and previous spinal instrumentation. In patients with pyogenic vertebral osteomyelitis (PVO) and previous instrumentation requiring surgical treatment, a decision must be made between a less-invasive noninstrumented surgery, including retaining the previous instrumentation, or a more invasive additional instrumented surgery involving the complete removal of the infected tissue and firm (...) of infection recurrence and mortality compared with noninstrumented surgery despite a larger number of involved vertebral levels and greater incidence of epidural abscesses. However, instrumented patients with PVO and previous instrumentation who experienced infection recurrence had worse clinical outcomes than those of the noninstrumented patients with PVO. Severe medical comorbidities, the presence of a psoas abscess, and methicillin-resistant Staphylococcus aureus infection were associated with a higher

2019 The Spine Journal

6. Treatment of Multidrug-Resistant Vancomycin-Resistant Enterococcus faecium Hardware-Associated Vertebral Osteomyelitis with Oritavancin plus Ampicillin. Full Text available with Trip Pro

Treatment of Multidrug-Resistant Vancomycin-Resistant Enterococcus faecium Hardware-Associated Vertebral Osteomyelitis with Oritavancin plus Ampicillin. Weekly oritavancin plus ampicillin continuous infusion combination therapy was used to successfully treat a deep spine vancomycin-resistant Enterococcus faecium infection associated with hardware. Checkerboard and time-kill assays confirmed synergy between these two antibiotics. Further synergies of oritavancin and ampicillin with rifampin

2019 Antimicrobial Agents and Chemotherapy

7. Cervical anaerobic vertebral osteomyelitis following surgical tracheotomy: a case report. Full Text available with Trip Pro

Cervical anaerobic vertebral osteomyelitis following surgical tracheotomy: a case report. We report a rare case of anaerobic vertebral osteomyelitis associated with surgical tracheotomy which has never been reported to the best of our knowledge.A healthy 39-year-old man was admitted to intensive care for a severe brain trauma injury where a surgical tracheotomy was performed. He was discharged to a rehabilitation centre after 54 days hospital stay. During rehabilitation, he developed (...) progressive and febrile tetraplegia associated with cervical pain, requiring an intensive care readmission. A polymicrobial anaerobic bloodstream infection was revealed and magnetic resonance imaging diagnosed cervical vertebral osteomyelitis. Both the type of anaerobic micro-organisms found and the timing of the symptoms strongly suggest that the surgical tracheotomy was responsible for this rare case of cervical vertebral osteomyelitis. The patient was successfully treated by a prolonged antimicrobial

2019 BMC Infectious Diseases

8. Impact of diagnostic bone biopsies on the management of non-vertebral osteomyelitis: A retrospective cohort study. Full Text available with Trip Pro

Impact of diagnostic bone biopsies on the management of non-vertebral osteomyelitis: A retrospective cohort study. Optimal antibiotic management of patients with osteomyelitis remains a challenge for many clinicians. Although image-guided bone biopsy (IGB) remains the gold standard, its role in confirming diagnosis and guiding antibiotic management is not clear in patients with non-vertebral osteomyelitis.To determine the diagnostic yield of IGB and its impact on antibiotic management in non (...) -vertebral osteomyelitis.Retrospective cohort study.Urban academic medical center.Patients admitted for non-vertebral osteomyelitis who underwent image-guided bone biopsy.Primary outcomes were microbiologic and histopathological results. We evaluated the impact of IGB on clinician-initiated changes in antibiotic regimen before and after biopsy.We evaluated 203 bone biopsies in 185 patients with clinical suspicion of osteomyelitis. 79% of patient received antibiotics prior to biopsy. Bone cultures were

2019 Medicine

9. Rapid emergence of cryptococcal fungemia, Mycobacterium chelonae vertebral osteomyelitis and gastro intestinal stromal tumor in a young HIV late presenter: a case report. Full Text available with Trip Pro

Rapid emergence of cryptococcal fungemia, Mycobacterium chelonae vertebral osteomyelitis and gastro intestinal stromal tumor in a young HIV late presenter: a case report. Highly active antiretroviral therapy has significantly changed the natural history of HIV infection, leading to a dramatic reduction of HIV-related morbidity and mortality. Late Presenters, Very Late Presenters and AIDS presenters still represent, also in Europe, including Italy, a huge challenge in terms of diagnostic (...) and therapeutic management.A 35-year-old male with a history of fever and back pain. HIV test resulted positive with a high HIV Viral Load and a very low T-CD4 number of cells (5 cells/mm3). Imaging investigations revealed multiple vertebral and pulmonary lesions together with abdominal and thoracic lymphadenopathy. Blood cultures were positive for Cryptococcus neoformans and for Staphylococcus haemolyticus. Lymphnode biopsy resulted positive in PCR for Non-Tuberculosis Mycobacteria (Mycobacterium chelonae

2018 BMC Infectious Diseases

10. Clinical effect of early bisphosphonate treatment for pyogenic vertebral osteomyelitis with osteoporosis: An analysis by the Cox proportional hazard model. (Abstract)

Clinical effect of early bisphosphonate treatment for pyogenic vertebral osteomyelitis with osteoporosis: An analysis by the Cox proportional hazard model. Patients with pyogenic vertebral osteomyelitis (PVO) are expected to have an increased risk of bone loss. Therefore, early bisphosphonate therapy would be clinically effective for PVO patients with osteoporosis.This study aimed to investigate the effect of bisphosphonate on clinical outcomes of PVO patients with osteoporosis.A retrospective (...) comparative study.PVO patients with osteoporosis.Four events of interest for Cox proportional hazard model included surgical treatment, recurrence of infection, subsequent fracture of adjacent vertebral bodies, and death.PVO patients were divided into three groups: group A (initiation of bisphosphonate within 6 weeks after PVO diagnosis), group B (initiation of bisphosphonate between 6 weeks and 3 months after PVO diagnosis), and group C (no treatment for osteoporosis). Cox proportional hazard model

2018 The Spine Journal

11. Bone mineral density in osteoporotic patients with pyogenic vertebral osteomyelitis: effect of early versus late treatment for osteoporosis. (Abstract)

Bone mineral density in osteoporotic patients with pyogenic vertebral osteomyelitis: effect of early versus late treatment for osteoporosis. Patients with pyogenic vertebral osteomyelitis (PVO) are at greater risk of bone loss. However, treatment guidelines for bone loss have been lacking. Early bisphosphonate treatment within 6 weeks after PVO diagnosis was significantly associated with superior outcome in femoral BMD at 2-year follow-up, compared to that with late treatment.Due to absence

2018 Osteoporosis International

12. Diagnostic Quandary: Salmonella Agbeni Vertebral Osteomyelitis and Epidural Abscess Full Text available with Trip Pro

Diagnostic Quandary: Salmonella Agbeni Vertebral Osteomyelitis and Epidural Abscess Salmonella vertebral discitis/osteomyelitis is a rare manifestation of Salmonella infection. Here, we report a case of a 54-year-old Caucasian male who presented with five weeks of progressively worsening bilateral low back, buttock, and lower extremity pain following an 8-foot fall onto concrete from a ladder. Initial workup following the fall included hip X-ray and MRI of the lumbar spine and revealed only (...) mild lumbar facet arthropathy and moderate left neural foraminal stenosis at L3-L4 without any concomitant hip or spine fracture. The patient's pain continued to increase in severity over the next several weeks, and he was evaluated by multiple healthcare professionals with no discovered pathology. Approximately 5 weeks following the fall, repeat CT scan and MRI were conducted which then revealed extensive findings of discitis/osteomyelitis at L5-S1 as well as an epidural abscess resulting

2018 Case reports in orthopedics

13. Vertebral Osteomyelitis Secondary to Pneumococcal Infection Full Text available with Trip Pro

Vertebral Osteomyelitis Secondary to Pneumococcal Infection Vertebral osteomyelitis secondary to pneumococcal infection is an uncommon condition caused by Streptococcus pneumoniae. Fever, back pain, and raised ESR are common features in the clinical setting. We report a 62-year-old female patient who presented with an unusual presentation. Later on, vertebral osteomyelitis secondary to pneumococcal infection was confirmed at T8, 9 by CT scan, MRI, and cytology. The patient was treated

2018 Case reports in infectious diseases

14. Vertebral Osteomyelitis Caused by Helicobacter cinaedi Identified Using Broad-range Polymerase Chain Reaction with Sequencing of the Biopsied Specimen Full Text available with Trip Pro

Vertebral Osteomyelitis Caused by Helicobacter cinaedi Identified Using Broad-range Polymerase Chain Reaction with Sequencing of the Biopsied Specimen A 65-year-old man presented with gradually exacerbating low back pain. Magnetic resonance imaging revealed vertebral osteomyelitis in the Th11-L2 vertebral bodies and discs. The patient showed negative findings on conventional cultures. Direct broad-range polymerase chain reaction (PCR) with sequencing of the biopsied specimen had the highest (...) similarity to the 16S rRNA gene of Helicobacter cinaedi. This case suggests that direct broad-range PCR with sequencing should be considered when conventional cultures cannot identify the causative organism of vertebral osteomyelitis, and that this method may be particularly useful when the pathogen is a fastidious organism, such as H. cinaedi.

2018 Internal Medicine

15. Lomentospora prolificans vertebral osteomyelitis with spinal epidural abscess in an immunocompetent woman: Case report and literature review Full Text available with Trip Pro

Lomentospora prolificans vertebral osteomyelitis with spinal epidural abscess in an immunocompetent woman: Case report and literature review Lomentospora prolificans is a rare cause of vertebral osteomyelitis. We report a case of L. prolificans thoracic vertebral osteomyelitis with spinal epidural abscess in a patient without apparent immunodeficiency. Clinical manifestations and radiographic findings could not distinguish from other etiologic agents. Treatment is also challenging because L

2018 Medical mycology case reports

16. Osteomielitis vertebral por Actinomyces: reporte de un caso Full Text available with Trip Pro

Osteomielitis vertebral por Actinomyces: reporte de un caso 29372636 2018 08 29 2018 11 13 1988-9518 31 1 2018 Feb Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Rev Esp Quimioter [Vertebral osteomyelitis due to Actinomyces: a case report]. 68-69 brizzi26jan2018 Brizzi B N BN Fernández Alonso C C Cesáreo Fernández Alonso, Servicio de Urgencias, Hospital Clínico San Carlos Calle Profesor Martín-Lagos s/n, 28040, Madrid, Spain. cesareofa (...) @hotmail.com. Nieto Sánchez A A González Del Castillo J J spa Case Reports Letter Osteomielitis vertebral por Actinomyces: reporte de un caso. 2018 01 26 Spain Rev Esp Quimioter 9108821 0214-3429 0 Anti-Bacterial Agents 75J73V1629 Ceftriaxone VZ8RRZ51VK Tobramycin IM Actinomycosis drug therapy microbiology Aged Anti-Bacterial Agents therapeutic use Ceftriaxone therapeutic use Humans Male Osteomyelitis drug therapy microbiology Tobramycin therapeutic use 2018 1 27 6 0 2018 8 30 6 0 2018 1 27 6 0 ppublish

2018 Revista Española de Quimioterapia

17. Pyogenic vertebral osteomyelitis of the elderly: Characteristics and outcomes. Full Text available with Trip Pro

Pyogenic vertebral osteomyelitis of the elderly: Characteristics and outcomes. The incidence of pyogenic vertebral osteomyelitis (PVO) has increased over the past two decades. One possible cause of this increase is the aging of the population, which results in more comorbidities in high income countries.To better characterize the clinical presentation and outcome of PVO in the elderly.We conducted a post-hoc analysis of a previously published trial that studied treatment duration in PVO

2017 PLoS ONE

18. An 11 Year Old Male with Vertebral Osteomyelitis and a Paraspinal Abscess. (Abstract)

An 11 Year Old Male with Vertebral Osteomyelitis and a Paraspinal Abscess. We report the case of an 11-year-old immunocompetent patient presenting with a 2-week history of upper back pain, diagnosed with thoracic vertebral osteomyelitis and a paraspinal abscess caused by Bartonella henselae. He was treated with gentamicin and doxycycline followed by oral rifampicin and doxycycline with favorable outcome.

2018 Pediatric Infectious Dsease Journal

19. Mycobacterium Avium complex vertebral osteomyelitis in the absence of HIV infection: a case report and review. Full Text available with Trip Pro

Mycobacterium Avium complex vertebral osteomyelitis in the absence of HIV infection: a case report and review. Mycobacterium Avium Complex (MAC) is an established microbiologic cause of pulmonary disease, lymphadenitis, and disseminated disease in cases of advanced immune suppression. However, MAC manifesting as vertebral osteomyelitis is less common, and is particularly rare in the absence of Acquired Immunodeficiency Syndrome (AIDS). Prompt diagnosis of MAC vertebral osteomyelitis (...) antibacterial therapy. Two weeks after her initial hospital discharge she represented with severe back pain and radiologic evidence of progressive disease in her lumbar spine. Two additional vertebral biopsies were required during her first 2 weeks of admission. MAC eventually grew from culture 14 days after collection. She was treated with ethambutol and rifampin and her symptoms resolved in 2 weeks, though therapy was continued for 12 months.MAC is an unusual cause of vertebral osteomyelitis in patients

2018 BMC Infectious Diseases

20. Salmonella potsdam causing lumbar vertebral osteomyelitis: A case report. Full Text available with Trip Pro

Salmonella potsdam causing lumbar vertebral osteomyelitis: A case report. Salmonella osteomyelitis is an uncommon complication of salmonella infection, especially the salmonella vertebral osteomyelitis (SVO).We reported a case of a 29-year-old female who presented with serious lower back pain and severe limitation of motion for 50 days with no obvious inducements. She once had a fever up to 39.5°C. Physical examination only revealed limited motion of lower back without neurological

2018 Medicine

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