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Vernal Conjunctivitis

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1. A Study of AK002 in Patients With Atopic Keratoconjunctivitis, Vernal Keratoconjunctivitis, and Perennial Allergic Conjunctivitis

A Study of AK002 in Patients With Atopic Keratoconjunctivitis, Vernal Keratoconjunctivitis, and Perennial Allergic Conjunctivitis A Study of AK002 in Patients With Atopic Keratoconjunctivitis, Vernal Keratoconjunctivitis, and Perennial Allergic Conjunctivitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have (...) reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study of AK002 in Patients With Atopic Keratoconjunctivitis, Vernal Keratoconjunctivitis, and Perennial Allergic Conjunctivitis (KRONOS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03379311

2017 Clinical Trials

2. Conjunctivitis - allergic: What mast cell stabilizers can be prescribed for allergic conjunctivitis?

drops can be useful for vernal keratoconjunctivitis and other allergic forms of conjunctivitis [ ] Sodium cromoglicate [ ; ] Licenced for use in allergic conjunctivitis and seasonal keratoconjunctivitis in adults and children — apply eye drops 4 times daily. Contraindications and cautions Avoid with hypersensitivity to the active substance or to any of the excipients. Use with caution in pregnancy (especially during the first trimester) and breastfeeding and only when there is a clear need (...) Conjunctivitis - allergic: What mast cell stabilizers can be prescribed for allergic conjunctivitis? Mast cell stabilizers | Prescribing information | Conjunctivitis - allergic | CKS | NICE Search CKS… Menu Mast cell stabilizers Conjunctivitis - allergic: What mast cell stabilizers can be prescribed for allergic conjunctivitis? Last revised in May 2017 What mast cell stabilizers can be prescribed for allergic conjunctivitis? Sodium cromoglicate (sodium cromoglycate) and nedocromil sodium eye

2017 NICE Clinical Knowledge Summaries

3. Conjunctivitis - allergic: What are the clinical features of allergic conjunctivitis?

of other eye conditions such as blepharitis or dry eye. For further information, see the CKS topics on and . Severe and chronic types of allergic conjunctivitis Vernal keratoconjunctivitis — more common and more severe in hot arid areas of the world (such as the Mediterranean basin, East Africa and India). It is more common in boys and typically resolves spontaneously after puberty. Symptoms are typically worse in spring but may occur throughout the year and include severe itching and copious fibrinous (...) Conjunctivitis - allergic: What are the clinical features of allergic conjunctivitis? Clinical features | Diagnosis | Conjunctivitis - allergic | CKS | NICE Search CKS… Menu Clinical features Conjunctivitis - allergic: What are the clinical features of allergic conjunctivitis? Last revised in May 2017 What are the clinical features of allergic conjunctivitis? Acute, seasonal and perennial allergic conjunctivitis Clinical presentation can be nonspecific but the hallmark symptom of allergic

2017 NICE Clinical Knowledge Summaries

4. Vernal Conjunctivitis

Vernal Conjunctivitis Vernal Conjunctivitis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Vernal Conjunctivitis Vernal (...) Conjunctivitis Aka: Vernal Conjunctivitis From Related Chapters II. Epidemiology Occurs annually in spring or early summer Affects adolescents Affects Males more often than females III. Pathophysiology Allergic response to light or heat IV. Symptoms Bilateral eye involvement Watery Photophobia Severe eye itching V. Signs Recurs in warm weather l injection with mucoid secretion Severe Palpebral Hard flattened papillae with furrows Large "cobblestone" appearance VI. Complications l Scarring and l Scarring VII

2018 FP Notebook

5. Ciclosporin (Verkazia) - Conjunctivitis, Keratitis

by an inflammation of the conjunctivitis with corneal involvement and tissue remodelling including papillae formation. It was first described by Arlt in 1846 who reported 3 cases of perilimbal swelling in young patients. The association with springtime (vernal) reflects the seasonal increase in signs and symptoms of the condition, particularly the high prevalence in hot, arid environments. Affected individuals have disease flares frequently during spring months, but can have signs and symptoms year round (...) Ciclosporin (Verkazia) - Conjunctivitis, Keratitis 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Union Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5555 Send a question via our website www.ema.europa.eu/contact © European Medicines Agency, 2018. Reproduction is authorised provided the source is acknowledged. 20 July 2017 EMA/505143/2017 Committee for Medicinal Products for Human Use (CHMP) Assessment report Verkazia International non

2018 European Medicines Agency - EPARs

6. Conjunctivitis - allergic: Scenario: Referral

management by an ophthalmologist is required for more severe cases. The person has severe or resistant allergic conjunctivitis: Atopic keratoconjunctivitis and vernal keratoconjunctivitis must be excluded. Resistant cases of perennial and seasonal allergic conjunctivitis may require specialist treatments, such as topical corticosteroids or immunotherapy. Consider referral to an allergy specialist if: The person has multisystem disease (for example nasal and respiratory symptoms) — allergen identification (...) with urgency dependent on clinical situation Diagnostic uncertainty or lack of appropriate equipment Diagnostic uncertainty because of a lack of appropriate equipment can have serious ocular and health implications [ ]. Recurrent and persistent conjunctivitis Prolonged severe itching may be due to atopic keratoconjunctivitis or vernal keratoconjunctivitis which require specialist management to avoid sight-threatening complications [ ]. Referral to an allergy specialist: Allergen identification may help

2019 NICE Clinical Knowledge Summaries

7. Conjunctivitis - allergic

conditions associated with an immunoglobulin E (IgE) hypersensitivity reaction including: Seasonal allergic conjunctivitis — occurs periodically and is associated with seasonal allergens (such as tree and grass pollen). Perennial allergic conjunctivitis — associated with non-seasonal environmental allergens often found in the home (such as house dust mites, mould spores or animal dander). Vernal keratoconjunctivitis — commonest and most severe in hot arid environments (such as the Mediterranean, West (...) Africa and India). Atopic keratoconjunctivitis — severe and usually associated with atopic dermatitis of the eyelids. Giant papillary conjunctivitis — also has a mechanical component and can occur as a result of chronic micro-trauma (for example from contact lens wear, ocular prostheses or ocular sutures). In most cases (excluding vernal and atopic keratoconjunctivitis) conjunctivitis does not cause permanent visual loss or structural damage. The most consistent clinical feature of allergic

2019 NICE Clinical Knowledge Summaries

8. Prevalence of vernal keratoconjunctivitis and its associated factors among children in Gambella town, southwest Ethiopia, June 2018. Full Text available with Trip Pro

Prevalence of vernal keratoconjunctivitis and its associated factors among children in Gambella town, southwest Ethiopia, June 2018. Vernal keratoconjunctivitis is a chronic bilateral severe form of allergic conjunctivitis which affects normal activities in school/work. It is a severe form of allergies in warm and dry tropical and sub-tropical countries. Its prevalence in Ethiopia ranges from 5.2% to7.3%. Most studies are institution based and do not address specific factors associated (...) with vernal keratoconjunctivitis. There is no a study that shows the magnitude of vernal keratoconjunctivitis in the study area.To assess the prevalence of vernal keratoconjunctivitis and its associated factors among children in Gambella town, Southwest Ethiopia, 2018.A community based cross-sectional study was conducted from April 25 to May 12, 2018, in Gambella town. A total of 578 study participants were selected using a systematic random sampling technique. A pre-tested semi-structured questionnaire

2019 PLoS ONE

9. Comment on: Systemic approach to managing vernal conjunctivitis in clinical practice and severity grading system and treatment algorithm Full Text available with Trip Pro

Comment on: Systemic approach to managing vernal conjunctivitis in clinical practice and severity grading system and treatment algorithm 27609172 2017 10 26 2018 12 02 1998-3689 64 7 2016 07 Indian journal of ophthalmology Indian J Ophthalmol Comment on: Systemic approach to managing vernal conjunctivitis in clinical practice and severity grading system and treatment algorithm. 544-5 10.4103/0301-4738.190171 Israni Neeraj Ashok NA Department of Ophthalmology, MGM Medical College and Hospital (...) Jul;64(7):545-6 27609173 Algorithms Conjunctiva Conjunctivitis Conjunctivitis, Allergic Humans Severity of Illness Index 2016 9 10 6 0 2016 9 10 6 0 2017 10 27 6 0 ppublish 27609172 IndianJOphthalmol_2016_64_7_544_190171 10.4103/0301-4738.190171 PMC5026087 Pediatr Allergy Immunol. 2014 Jun;25(4):314-22 24438133 Indian J Ophthalmol. 2016 Feb;64(2):145-8 27050351 Arch Ophthalmol. 1981 Feb;99(2):302-4 6451212

2016 Indian journal of ophthalmology

10. Component-resolved diagnostics in vernal conjunctivitis. (Abstract)

Component-resolved diagnostics in vernal conjunctivitis. Conventional diagnostic tests in allergy are insufficient to clarify the origin of vernal conjunctivitis (VC).To evaluate IgE-mediated hypersensitivity by component-resolved diagnosis (CRD) in tears and serum from patients with VC and to evaluate how to treat patients with identified triggering allergens by specific immunotherapy.Patients were divided into 3 groups: (1) patients with VC (25 patients), (2) patients allergic to grass pollen (...) with seasonal allergic conjunctivitis (AC) (50 patients), and (3) healthy blood donors (50 patients). If triggering allergens were detected, specific conventional immunotherapy was administered for 1 year.Twenty-five patients with VC were evaluated. The identified triggering allergens were n Lol p 1 (11 patients), n Cyn d 1 (8 patients), group 4 and 6 grasses (6 patients), and group 5 grasses (5 patients). Prick test and pollen IgE test results were positive in one patient. Clinical improvement was observed

2015 Asthma & Immunology

11. Comparative Evaluation of Tacrolimus Versus Interferon Alpha-2b Eye Drops in the Treatment of Vernal Keratoconjunctivitis: A Randomized, Double-Masked Study. (Abstract)

Comparative Evaluation of Tacrolimus Versus Interferon Alpha-2b Eye Drops in the Treatment of Vernal Keratoconjunctivitis: A Randomized, Double-Masked Study. 29040120 2018 09 20 2018 10 04 1536-4798 37 1 2018 01 Cornea Cornea Comparative Evaluation of Tacrolimus Versus Interferon Alpha-2b Eye Drops in the Treatment of Vernal Keratoconjunctivitis: A Randomized, Double-Masked Study. e1 10.1097/ICO.0000000000001357 Gupta Parul Chawla PC Department of Ophthalmology, Post Graduate Institute (...) of Medical Education and Research, Chandigarh, India. Ram Jagat J eng Letter Comment United States Cornea 8216186 0277-3740 0 Immunosuppressive Agents 0 Interferon-alpha 0 Ophthalmic Solutions WM0HAQ4WNM Tacrolimus IM Cornea. 2017 Jun;36(6):675-678 28399035 Conjunctivitis, Allergic Double-Blind Method Humans Immunosuppressive Agents Interferon-alpha Ophthalmic Solutions Tacrolimus 2017 10 19 6 0 2018 9 21 6 0 2017 10 18 6 0 ppublish 29040120 10.1097/ICO.0000000000001357

2018 Cornea Controlled trial quality: uncertain

12. Vernal keratoconjunctivitis Full Text available with Trip Pro

Vernal keratoconjunctivitis Vernal keratoconjunctivitis (VKC) is a chronic allergic conjunctivitis that is most often seen in young, males. Although most types of allergic conjunctivitis do not affect vision, VKC is unusual in that damage to the cornea from the condition can result in vision loss. Although it is typically seasonal, year-round symptoms can be seen, which can lead to uncertain diagnoses being made. Although the pathophysiology of VKC is better understood in recent years, allowing

2018 Clinical ophthalmology (Auckland, N.Z.)

13. A Novel Combined Therapy for Refractory Vernal Keratoconjunctivitis

Manufactured in and Exported from the U.S.: No Keywords provided by Jin Yuan, Zhongshan Ophthalmic Center, Sun Yat-sen University: Refractory Vernal Keratoconjunctivitis 0.1% tacrolimus loteprednol etabonate 0.5%/tobramycin 0.3% Additional relevant MeSH terms: Layout table for MeSH terms Keratoconjunctivitis Conjunctivitis, Allergic Conjunctivitis Conjunctival Diseases Eye Diseases Keratitis Corneal Diseases Hypersensitivity, Immediate Hypersensitivity Immune System Diseases Tacrolimus Tobramycin (...) A Novel Combined Therapy for Refractory Vernal Keratoconjunctivitis A Novel Combined Therapy for Refractory Vernal Keratoconjunctivitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Novel Combined

2018 Clinical Trials

14. Dermatologic Tacrolimus Ointment on Eyelids in the Treatment of Refractory Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis

Dermatologic Tacrolimus Ointment on Eyelids in the Treatment of Refractory Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis Dermatologic Tacrolimus Ointment on Eyelids in the Treatment of Refractory Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning (...) You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Dermatologic Tacrolimus Ointment on Eyelids in the Treatment of Refractory Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider

2018 Clinical Trials

15. Tacrolimus versus Cyclosporine- Comparative Evaluation as First line drug in Vernal keratoconjuctivitis. Full Text available with Trip Pro

Tacrolimus versus Cyclosporine- Comparative Evaluation as First line drug in Vernal keratoconjuctivitis. The aim of the study was to evaluate and compare the efficacy, side effects and recurrence rate of vernal kerato conjunctivitis (VKC) with 0.03% tacrolimus and 0.05% cyclosporin.A prospective randomised double blinded comparative study was conducted at a tertiary eye center. 46 Patients of VKC between March 2015- August 2015 were randomly divided into two groups and treated for 6weeks

2017 Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH Controlled trial quality: uncertain

16. Vernal keratoconjunctivitis treated with Omalizumab: A case series. (Abstract)

Vernal keratoconjunctivitis treated with Omalizumab: A case series. 28543949 2018 06 01 2018 06 01 1399-3038 28 5 2017 Aug Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology Pediatr Allergy Immunol Vernal keratoconjunctivitis treated with omalizumab: A case series. 503-505 10.1111/pai.12737 Occasi Francesca F http://orcid.org/0000-0001-9160-5782 Department of Pediatrics, "Sapienza" University of Rome, Rome, Italy. Duse Marzia M (...) , Rome, Italy. Zicari Anna Maria AM Department of Pediatrics, "Sapienza" University of Rome, Rome, Italy. eng Letter England Pediatr Allergy Immunol 9106718 0905-6157 0 Anti-Allergic Agents 2P471X1Z11 Omalizumab IM Anti-Allergic Agents therapeutic use Child Conjunctivitis, Allergic drug therapy Female Follow-Up Studies Humans Keratoconjunctivitis drug therapy Male Omalizumab therapeutic use Treatment Outcome 2017 5 26 6 0 2018 6 2 6 0 2017 5 26 6 0 ppublish 28543949 10.1111/pai.12737

2017 Pediatric Allergy and Immunology

17. Diagnosing and managing allergic conjunctivitis in childhood: the allergist's perspective. (Abstract)

and not overly difficult to diagnose and treat when associated with rhinitis leading to allergic rhinoconjunctivitis. An ophthalmologist should be consulted when conjunctivitis occurs alone and if another form of conjunctivitis is suspected, such as perennial allergic conjunctivitis (PAC), vernal keratoconjunctivitis (VKC) or atopic keratoconjunctivitis (AKC). When IgE-mediated hypersensitivity assessment does not establish aetiological diagnosis a conjunctival allergen provocation test (CAPT) can (...) Diagnosing and managing allergic conjunctivitis in childhood: the allergist's perspective. Allergic conjunctivitis (AC) in childhood often poses problems of diagnosis and management for the allergist. We present the salient points concerning the diagnosis and treatment of ocular allergy (OA) emerging from a large cohort survey conducted jointly in the departments of ophthalmology and paediatric allergy in a French teaching hospital. Seasonal acute conjunctivitis (SAC) is a common disorder

2019 Pediatric Allergy and Immunology

18. Vernal Conjunctivitis

Vernal Conjunctivitis Vernal Conjunctivitis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Vernal Conjunctivitis Vernal (...) Conjunctivitis Aka: Vernal Conjunctivitis From Related Chapters II. Epidemiology Occurs annually in spring or early summer Affects adolescents Affects Males more often than females III. Pathophysiology Allergic response to light or heat IV. Symptoms Bilateral eye involvement Watery Photophobia Severe eye itching V. Signs Recurs in warm weather l injection with mucoid secretion Severe Palpebral Hard flattened papillae with furrows Large "cobblestone" appearance VI. Complications l Scarring and l Scarring VII

2015 FP Notebook

19. Vernal conjunctivitis in the negro Full Text available with Trip Pro

Vernal conjunctivitis in the negro 16692058 2006 06 01 2008 11 20 0065-9533 10 Pt 3 1905 Transactions of the American Ophthalmological Society Trans Am Ophthalmol Soc Vernal conjunctivitis in the negro. 556-65 Roy D D eng Journal Article United States Trans Am Ophthalmol Soc 7506106 0065-9533 1905 1 1 0 0 1905 1 1 0 1 1905 1 1 0 0 ppublish 16692058 PMC1322506

1905 Transactions of the American Ophthalmological Society

20. Clinical trial of topical disodium cromoglycate in vernal kerato-conjunctivitis. (Abstract)

Clinical trial of topical disodium cromoglycate in vernal kerato-conjunctivitis. 4632185 1973 05 03 2013 11 21 0009-9090 2 2 1972 Jun Clinical allergy Clin. Allergy Clinical trial of topical disodium cromoglycate in vernal kerato-conjunctivitis. 99-107 Easty D L DL Rice N S NS Jones B R BR eng Clinical Trial Controlled Clinical Trial Journal Article Randomized Controlled Trial England Clin Allergy 0311172 0009-9090 0 Glucocorticoids 0 Ophthalmic Solutions 0 Placebos Q2WXR1I0PK Cromolyn Sodium

1973 Clinical Allergy Controlled trial quality: uncertain

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