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Vernal Conjunctivitis

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1. A Study of AK002 in Patients With Atopic Keratoconjunctivitis, Vernal Keratoconjunctivitis, and Perennial Allergic Conjunctivitis

A Study of AK002 in Patients With Atopic Keratoconjunctivitis, Vernal Keratoconjunctivitis, and Perennial Allergic Conjunctivitis A Study of AK002 in Patients With Atopic Keratoconjunctivitis, Vernal Keratoconjunctivitis, and Perennial Allergic Conjunctivitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have (...) reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study of AK002 in Patients With Atopic Keratoconjunctivitis, Vernal Keratoconjunctivitis, and Perennial Allergic Conjunctivitis (KRONOS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03379311

2017 Clinical Trials

2. Vernal keratoconjunctivitis

Vernal keratoconjunctivitis Vernal Keratoconjunctivitis (Spring catarrh) submit The College submit You're here: Vernal Keratoconjunctivitis (Spring catarrh) Vernal Keratoconjunctivitis (Spring catarrh) The CMGs are guidelines on the diagnosis and management of a range of common and rare, but important, eye conditions that present with varying frequency in primary and first contact care. Share options Please login to view the images or . Aetiology Rare allergic disorder of children (prevalence (...) be required for the removal of corneal plaque Evidence base *GRADE: Grading of Recommendations Assessment, Development and Evaluation ( ) Sources of evidence Avunduk AM, Avunduk MC, Kapicioglu Z, Akyol N, Tavli L. Mechanisms and comparison of anti-allergic efficacy of topical lodoxamide and cromolyn sodium treatment in vernal keratoconjunctivitis. Ophthalmology. 2000;107:1333-7 De Smedt S, Nkurikiye J, Fonteyne Y, Tuft S, De Bacquer D, Gilbert C, Kestelyn P. Topical ciclosporin in the treatment of vernal

2019 College of Optometrists

3. Vernal Conjunctivitis

Vernal Conjunctivitis Vernal Conjunctivitis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Vernal Conjunctivitis Vernal (...) Conjunctivitis Aka: Vernal Conjunctivitis From Related Chapters II. Epidemiology Occurs annually in spring or early summer Affects adolescents Affects Males more often than females III. Pathophysiology Allergic response to light or heat IV. Symptoms Bilateral eye involvement Watery Photophobia Severe eye itching V. Signs Recurs in warm weather l injection with mucoid secretion Severe Palpebral Hard flattened papillae with furrows Large "cobblestone" appearance VI. Complications l Scarring and l Scarring VII

2018 FP Notebook

4. Comment on: Systemic approach to managing vernal conjunctivitis in clinical practice and severity grading system and treatment algorithm (PubMed)

Comment on: Systemic approach to managing vernal conjunctivitis in clinical practice and severity grading system and treatment algorithm 27609172 2017 10 26 2018 12 02 1998-3689 64 7 2016 07 Indian journal of ophthalmology Indian J Ophthalmol Comment on: Systemic approach to managing vernal conjunctivitis in clinical practice and severity grading system and treatment algorithm. 544-5 10.4103/0301-4738.190171 Israni Neeraj Ashok NA Department of Ophthalmology, MGM Medical College and Hospital (...) Jul;64(7):545-6 27609173 Algorithms Conjunctiva Conjunctivitis Conjunctivitis, Allergic Humans Severity of Illness Index 2016 9 10 6 0 2016 9 10 6 0 2017 10 27 6 0 ppublish 27609172 IndianJOphthalmol_2016_64_7_544_190171 10.4103/0301-4738.190171 PMC5026087 Pediatr Allergy Immunol. 2014 Jun;25(4):314-22 24438133 Indian J Ophthalmol. 2016 Feb;64(2):145-8 27050351 Arch Ophthalmol. 1981 Feb;99(2):302-4 6451212

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2016 Indian journal of ophthalmology

5. Ciclosporin (Verkazia) - Conjunctivitis, Keratitis

by an inflammation of the conjunctivitis with corneal involvement and tissue remodelling including papillae formation. It was first described by Arlt in 1846 who reported 3 cases of perilimbal swelling in young patients. The association with springtime (vernal) reflects the seasonal increase in signs and symptoms of the condition, particularly the high prevalence in hot, arid environments. Affected individuals have disease flares frequently during spring months, but can have signs and symptoms year round (...) Ciclosporin (Verkazia) - Conjunctivitis, Keratitis 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Union Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5555 Send a question via our website www.ema.europa.eu/contact © European Medicines Agency, 2018. Reproduction is authorised provided the source is acknowledged. 20 July 2017 EMA/505143/2017 Committee for Medicinal Products for Human Use (CHMP) Assessment report Verkazia International non

2018 European Medicines Agency - EPARs

6. Conjunctivitis (seasonal & perennial allergic)

: mild to moderate oedema (peri-orbital oedema in severe cases) Bulbar and tarsal conjunctiva: chemosis (oedema), hyperaemia and diffuse papillary reaction Cornea: uninvolved Differential diagnosis Vernal or Atopic Keratoconjunctivitis (cornea usually involved) Other allergic conjunctivitis Acute Allergic Conjunctivitis (AAC) (see Clinical Management Guideline on ) contact conjunctivitis (e.g. to drug or preservative in eye drops) (see Clinical Management Guideline on ) Contact Lens-Associated (...) Conjunctivitis (seasonal & perennial allergic) Seasonal Allergic Conjunctivitis (Hay Fever Conjunctivitis); Perennial Allergic Conjunctivitis submit The College submit You're here: Seasonal Allergic Conjunctivitis (Hay Fever Conjunctivitis); Perennial Allergic Conjunctivitis Seasonal Allergic Conjunctivitis (Hay Fever Conjunctivitis); Perennial Allergic Conjunctivitis The CMGs are guidelines on the diagnosis and management of a range of common and rare, but important, eye conditions

2019 College of Optometrists

7. Prevalence of vernal keratoconjunctivitis and its associated factors among children in Gambella town, southwest Ethiopia, June 2018. (PubMed)

Prevalence of vernal keratoconjunctivitis and its associated factors among children in Gambella town, southwest Ethiopia, June 2018. Vernal keratoconjunctivitis is a chronic bilateral severe form of allergic conjunctivitis which affects normal activities in school/work. It is a severe form of allergies in warm and dry tropical and sub-tropical countries. Its prevalence in Ethiopia ranges from 5.2% to7.3%. Most studies are institution based and do not address specific factors associated (...) with vernal keratoconjunctivitis. There is no a study that shows the magnitude of vernal keratoconjunctivitis in the study area.To assess the prevalence of vernal keratoconjunctivitis and its associated factors among children in Gambella town, Southwest Ethiopia, 2018.A community based cross-sectional study was conducted from April 25 to May 12, 2018, in Gambella town. A total of 578 study participants were selected using a systematic random sampling technique. A pre-tested semi-structured questionnaire

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2019 PLoS ONE

8. Component-resolved diagnostics in vernal conjunctivitis. (PubMed)

Component-resolved diagnostics in vernal conjunctivitis. Conventional diagnostic tests in allergy are insufficient to clarify the origin of vernal conjunctivitis (VC).To evaluate IgE-mediated hypersensitivity by component-resolved diagnosis (CRD) in tears and serum from patients with VC and to evaluate how to treat patients with identified triggering allergens by specific immunotherapy.Patients were divided into 3 groups: (1) patients with VC (25 patients), (2) patients allergic to grass pollen (...) with seasonal allergic conjunctivitis (AC) (50 patients), and (3) healthy blood donors (50 patients). If triggering allergens were detected, specific conventional immunotherapy was administered for 1 year.Twenty-five patients with VC were evaluated. The identified triggering allergens were n Lol p 1 (11 patients), n Cyn d 1 (8 patients), group 4 and 6 grasses (6 patients), and group 5 grasses (5 patients). Prick test and pollen IgE test results were positive in one patient. Clinical improvement was observed

2015 Asthma & Immunology

9. Vernal keratoconjunctivitis (PubMed)

Vernal keratoconjunctivitis Vernal keratoconjunctivitis (VKC) is a chronic allergic conjunctivitis that is most often seen in young, males. Although most types of allergic conjunctivitis do not affect vision, VKC is unusual in that damage to the cornea from the condition can result in vision loss. Although it is typically seasonal, year-round symptoms can be seen, which can lead to uncertain diagnoses being made. Although the pathophysiology of VKC is better understood in recent years, allowing

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2018 Clinical ophthalmology (Auckland, N.Z.)

10. A Novel Combined Therapy for Refractory Vernal Keratoconjunctivitis

Manufactured in and Exported from the U.S.: No Keywords provided by Jin Yuan, Zhongshan Ophthalmic Center, Sun Yat-sen University: Refractory Vernal Keratoconjunctivitis 0.1% tacrolimus loteprednol etabonate 0.5%/tobramycin 0.3% Additional relevant MeSH terms: Layout table for MeSH terms Keratoconjunctivitis Conjunctivitis, Allergic Conjunctivitis Conjunctival Diseases Eye Diseases Keratitis Corneal Diseases Hypersensitivity, Immediate Hypersensitivity Immune System Diseases Tacrolimus Tobramycin (...) A Novel Combined Therapy for Refractory Vernal Keratoconjunctivitis A Novel Combined Therapy for Refractory Vernal Keratoconjunctivitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Novel Combined

2018 Clinical Trials

11. Dermatologic Tacrolimus Ointment on Eyelids in the Treatment of Refractory Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis

Dermatologic Tacrolimus Ointment on Eyelids in the Treatment of Refractory Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis Dermatologic Tacrolimus Ointment on Eyelids in the Treatment of Refractory Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning (...) You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Dermatologic Tacrolimus Ointment on Eyelids in the Treatment of Refractory Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider

2018 Clinical Trials

12. Comparative Evaluation of Tacrolimus Versus Interferon Alpha-2b Eye Drops in the Treatment of Vernal Keratoconjunctivitis: A Randomized, Double-Masked Study. (PubMed)

Comparative Evaluation of Tacrolimus Versus Interferon Alpha-2b Eye Drops in the Treatment of Vernal Keratoconjunctivitis: A Randomized, Double-Masked Study. 29040120 2018 09 20 2018 10 04 1536-4798 37 1 2018 01 Cornea Cornea Comparative Evaluation of Tacrolimus Versus Interferon Alpha-2b Eye Drops in the Treatment of Vernal Keratoconjunctivitis: A Randomized, Double-Masked Study. e1 10.1097/ICO.0000000000001357 Gupta Parul Chawla PC Department of Ophthalmology, Post Graduate Institute (...) of Medical Education and Research, Chandigarh, India. Ram Jagat J eng Letter Comment United States Cornea 8216186 0277-3740 0 Immunosuppressive Agents 0 Interferon-alpha 0 Ophthalmic Solutions WM0HAQ4WNM Tacrolimus IM Cornea. 2017 Jun;36(6):675-678 28399035 Conjunctivitis, Allergic Double-Blind Method Humans Immunosuppressive Agents Interferon-alpha Ophthalmic Solutions Tacrolimus 2017 10 19 6 0 2018 9 21 6 0 2017 10 18 6 0 ppublish 29040120 10.1097/ICO.0000000000001357

2018 Cornea Controlled trial quality: uncertain

13. Vernal keratoconjunctivitis treated with Omalizumab: A case series. (PubMed)

Vernal keratoconjunctivitis treated with Omalizumab: A case series. 28543949 2018 06 01 2018 06 01 1399-3038 28 5 2017 Aug Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology Pediatr Allergy Immunol Vernal keratoconjunctivitis treated with omalizumab: A case series. 503-505 10.1111/pai.12737 Occasi Francesca F http://orcid.org/0000-0001-9160-5782 Department of Pediatrics, "Sapienza" University of Rome, Rome, Italy. Duse Marzia M (...) , Rome, Italy. Zicari Anna Maria AM Department of Pediatrics, "Sapienza" University of Rome, Rome, Italy. eng Letter England Pediatr Allergy Immunol 9106718 0905-6157 0 Anti-Allergic Agents 2P471X1Z11 Omalizumab IM Anti-Allergic Agents therapeutic use Child Conjunctivitis, Allergic drug therapy Female Follow-Up Studies Humans Keratoconjunctivitis drug therapy Male Omalizumab therapeutic use Treatment Outcome 2017 5 26 6 0 2018 6 2 6 0 2017 5 26 6 0 ppublish 28543949 10.1111/pai.12737

2017 Pediatric Allergy and Immunology

14. Tacrolimus versus Cyclosporine- Comparative Evaluation as First line drug in Vernal keratoconjuctivitis. (PubMed)

Tacrolimus versus Cyclosporine- Comparative Evaluation as First line drug in Vernal keratoconjuctivitis. The aim of the study was to evaluate and compare the efficacy, side effects and recurrence rate of vernal kerato conjunctivitis (VKC) with 0.03% tacrolimus and 0.05% cyclosporin.A prospective randomised double blinded comparative study was conducted at a tertiary eye center. 46 Patients of VKC between March 2015- August 2015 were randomly divided into two groups and treated for 6weeks

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2017 Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH Controlled trial quality: uncertain

15. Diagnosing and managing allergic conjunctivitis in childhood: the allergist's perspective. (PubMed)

and not overly difficult to diagnose and treat when associated with rhinitis leading to allergic rhinoconjunctivitis. An ophthalmologist should be consulted when conjunctivitis occurs alone and if another form of conjunctivitis is suspected, such as perennial allergic conjunctivitis (PAC), vernal keratoconjunctivitis (VKC) or atopic keratoconjunctivitis (AKC). When IgE-mediated hypersensitivity assessment does not establish aetiological diagnosis a conjunctival allergen provocation test (CAPT) can (...) Diagnosing and managing allergic conjunctivitis in childhood: the allergist's perspective. Allergic conjunctivitis (AC) in childhood often poses problems of diagnosis and management for the allergist. We present the salient points concerning the diagnosis and treatment of ocular allergy (OA) emerging from a large cohort survey conducted jointly in the departments of ophthalmology and paediatric allergy in a French teaching hospital. Seasonal acute conjunctivitis (SAC) is a common disorder

2019 Pediatric Allergy and Immunology

16. Conjunctivitis - allergic

in the home (such as house dust mites, mould spores or animal dander). Vernal keratoconjunctivitis — commonest and most severe in hot arid environments (such as the Mediterranean, West Africa and India). Atopic keratoconjunctivitis — severe and usually associated with atopic dermatitis of the eyelids. Giant papillary conjunctivitis — also has a mechanical component and can occur as a result of chronic micro-trauma (for example from contact lens wear, ocular prostheses or ocular sutures). In most cases (...) (excluding vernal and atopic keratoconjunctivitis) conjunctivitis does not cause permanent visual loss or structural damage. The most consistent clinical feature of allergic conjunctivitis is itching. Other features include watery or mucoid discharge, conjunctival redness (injection) and oedema of the conjunctiva (chemosis) and eyelid. Serious causes of red eye (such as acute glaucoma, corneal ulcer, keratitis, iritis, scleritis and trauma) must be excluded — urgent referral to ophthalmology is required

2017 NICE Clinical Knowledge Summaries

17. Vitamin D levels in children affected by Vernal Keratoconjuctivitis. (PubMed)

Vitamin D levels in children affected by Vernal Keratoconjuctivitis. Vernal keratoconjunctivitis (VKC) is a chronic and often severe bilateral conjunctivitis. VKC etiology still remains unclear although endocrine, genetic, neurogenic and environmental factors have been implicated. Vitamin D is a fat-soluble prohormone whose main function is the regulation of calcium and phosphate metabolism. The aim of this study was to evaluate serum vitamin D in children affected by VKC compared

2016 Current medical research and opinion

18. Vernal Conjunctivitis

Vernal Conjunctivitis Vernal Conjunctivitis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Vernal Conjunctivitis Vernal (...) Conjunctivitis Aka: Vernal Conjunctivitis From Related Chapters II. Epidemiology Occurs annually in spring or early summer Affects adolescents Affects Males more often than females III. Pathophysiology Allergic response to light or heat IV. Symptoms Bilateral eye involvement Watery Photophobia Severe eye itching V. Signs Recurs in warm weather l injection with mucoid secretion Severe Palpebral Hard flattened papillae with furrows Large "cobblestone" appearance VI. Complications l Scarring and l Scarring VII

2015 FP Notebook

19. Clinical Evaluation of Hylo-Dual Versus Patanol in Children With Seasonal Allergic Conjunctivitis

in the pediatric population. Half of participants will receive Hylo-Dual, while the other half will receive Olopatadine treatment for 2 months. Condition or disease Intervention/treatment Phase Conjunctivitis, Allergic Conjunctivitis, Vernal Drug: Hyaluronic acid 0.05% & Ectoine 2.0% Drug: Olopatadine hydrochloride ophthalmic solution 0.1% Phase 4 Detailed Description: Seasonal allergic conjunctivitis (SAC) is an inflammatory response of the conjunctiva triggered by exposure to seasonal allergens. SAC (...) Clinical Evaluation of Hylo-Dual Versus Patanol in Children With Seasonal Allergic Conjunctivitis Clinical Evaluation of Hylo-Dual Versus Patanol in Children With Seasonal Allergic Conjunctivitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove

2017 Clinical Trials

20. Allergic conjunctivitis in Asia (PubMed)

Allergic conjunctivitis in Asia Allergic conjunctivitis (AC), which may be acute or chronic, is associated with rhinitis in 30%-70% of affected individuals, hence the term allergic rhinoconjunctivitis (AR/C). Seasonal and perennial AC is generally milder than the more chronic and persistent atopic and vernal keratoconjunctivitis. Natural allergens like house dust mites (HDM), temperate and subtropical grass and tree pollen are important triggers that drive allergic inflammation in AC

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2017 Asia Pacific allergy

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